Abstract

This paper describes a photoelectric device that is intended to serve as a replacement for degenerated photoreceptor cells in the retina. The device is a kind of silicon based micro-photodiode arrays. The final implant devices were approximately 100 microns in thickness and ranged in diameter from 2.5 to 3.5 mm. The individual photodiode subunits on the device is approximately 250*250 (micron) and the isolated channel between these subunits is about 50-micron width. The implant feasibility of device was tested in vivo and in vitro. The results show that the device has good biocompatibility. When it was implanted into rabbits and powered by light, visual evoked potential (VEP) can be induced.

© 2005 Chinese Optics Letters

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2002 (4)

E. Margalit, M. Maia, and D. James, Survey of Ophthalmology 47, 335 (2002).

E. Zrenner, Science 295, 1022 (2002).

A. Y. Chow, M. T. Pardue, and J. I. Perlman, J. Rehabil Res. Dev. 39, 313 (2002).

H. Hammerle, K. Kobuch, and K. Kohler, Biomaterials 23, 797 (2002).

2001 (2)

A. Y. Chow, M. T. Pardue, and V. Y. Chow, IEEE Trans. Neural Systems and Rehabilitation Engineering 19, 86 (2001).

M. S. Humayun, Trans. Am. Ophthalmol 99, 271 (2001).

1996 (1)

M. Humayun, E. de Juan, and G. Dagnelie, Arch. Ophthalmology 114, 40 (1996).

Arch. Ophthalmology (1)

M. Humayun, E. de Juan, and G. Dagnelie, Arch. Ophthalmology 114, 40 (1996).

Biomaterials (1)

H. Hammerle, K. Kobuch, and K. Kohler, Biomaterials 23, 797 (2002).

IEEE Trans. Neural Systems and Rehabilitation Engineering (1)

A. Y. Chow, M. T. Pardue, and V. Y. Chow, IEEE Trans. Neural Systems and Rehabilitation Engineering 19, 86 (2001).

J. Rehabil Res. Dev. (1)

A. Y. Chow, M. T. Pardue, and J. I. Perlman, J. Rehabil Res. Dev. 39, 313 (2002).

Science (1)

E. Zrenner, Science 295, 1022 (2002).

Survey of Ophthalmology (1)

E. Margalit, M. Maia, and D. James, Survey of Ophthalmology 47, 335 (2002).

Trans. Am. Ophthalmol (1)

M. S. Humayun, Trans. Am. Ophthalmol 99, 271 (2001).

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