Abstract

In this paper, we present a three-parametric model using Raman and fluorescence spectroscopy for detection and analysis of esophagus dysphasia and esophagus cancer. The model was set up from more than 1000 samples. And 56 samples were used to test this algorithm of the model prospectively. The serum spectra were excited by laser of the wavelengths 488.0 and 514.5 nm. The apparent differences of auto-fluorescence and Raman spectroscopy were observed for patients compared to the normal: the majority of the fluorescence spectra did not have violent alteration, but three Raman peaks disappeared or were found to be very weak. Moreover, 'Delta lambda' value (red shift of fluorescence peak) and 'alpha'-value (rate of fluorescence intensity) also provide the reference for future research. And I-value (intensity of Raman peak) will decrease with progression of the tumor. The result of spectral analysis is accordance with the clinical diagnosis.

© 2005 Chinese Optics Letters

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Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, Int. J. Cancer 107, 1047 (2003).

H. Yamazaki, S. Kaminaka, E. Kohda, M. Mukai, and H. Hamaguchi, Radiation Medicine 21, 1 (2003).

2001 (1)

I. Georgakoudi, B. C. Jacobson, J. Van Dam, V. Backman, M. B. Wallace, M. G. Muller, Q. Zhang, K. Badizadegan, D. Sun, G. A. Thomas, L. T. Perelman, and M. S. Feld, Gastroenterology 120, 1620 (2001).

2000 (2)

M. B. Wallace, L. T. Perelman, V. Backman, J. M. Crawford, M. Fitzmaurice, M. Seiler, K. Badizadegan, S. J. Shields, I. Itzkan, R. R. Dasari, J. Van Dam, and M. S. Feld, Gastroenterology 119, 677 (2000).

B. W. Smith and J. D. Winefordner, Talanta 51, 131 (2000).

1999 (1)

1998 (1)

1996 (1)

Q. Ma, H. Zhou, X. Li, and D. Xu, Chin. J. Chromatography 14, 277 (1996).

1989 (1)

Appl. Opt. (1)

Appl. Spectrosc. (1)

Chin. J. Chromatography (1)

Q. Ma, H. Zhou, X. Li, and D. Xu, Chin. J. Chromatography 14, 277 (1996).

Gastroenterology (2)

M. B. Wallace, L. T. Perelman, V. Backman, J. M. Crawford, M. Fitzmaurice, M. Seiler, K. Badizadegan, S. J. Shields, I. Itzkan, R. R. Dasari, J. Van Dam, and M. S. Feld, Gastroenterology 119, 677 (2000).

I. Georgakoudi, B. C. Jacobson, J. Van Dam, V. Backman, M. B. Wallace, M. G. Muller, Q. Zhang, K. Badizadegan, D. Sun, G. A. Thomas, L. T. Perelman, and M. S. Feld, Gastroenterology 120, 1620 (2001).

Int. J. Cancer (1)

Z. Huang, A. McWilliams, H. Lui, D. I. McLean, S. Lam, and H. Zeng, Int. J. Cancer 107, 1047 (2003).

J. Opt. Soc. Am. B (1)

Radiation Medicine (1)

H. Yamazaki, S. Kaminaka, E. Kohda, M. Mukai, and H. Hamaguchi, Radiation Medicine 21, 1 (2003).

Talanta (1)

B. W. Smith and J. D. Winefordner, Talanta 51, 131 (2000).

Other (3)

S. K. Gaby, A. Bendich, V. Singh, and L. Machlin, (eds.) Vitamin Intake and Health: A Scientific Review (Marcel Dekker Inc., New York, 1991).

Spectral Meter (Tsinghua University Press, Beijing).

P. R. Carry, Biochemical Application of Raman and Resonance Spectroscopes (Academic Press, New York, 1982).

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