Abstract

In this paper, the propagation characteristics of near-infrared (NIR) light in the palm tissue are analyzed, and the principle and feasibility of using transcutaneous diffuse reflectance spectroscopy for non-invasive blood glucose detection are presented. An optical probe suitable for measuring the diffuse reflectance spectrum of human palm and a non-invasive blood glucose detection system using NIR spectroscopy are designed. Based on this system, oral glucose tolerance tests are performed to measure the blood glucose concentrations of two young healthy volunteers. The partial least square calibration model is then constructed by all individual experimental data. The final result shows that correlation coefficients of the two experiments between the predicted blood glucose concentrations and the reference blood glucose concentrations are 0.9870 and 0.9854, respectively. The root mean square errors of prediction of full cross validation are 0.54 and 0.52 mmol/l, respectively.

© 2005 Chinese Optics Letters

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  1. O. S. Khalil, Clinical Chem. 45, 165 (1999).
  2. Dahne, Claus, Gross, and Daniel, Spectrophotometric method and apparatus for the non-invasive determination of glucose in body tissues US patent 4655225 (April 7, 1987).
  3. S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).
  4. J. Tenhunen, H. Kopola, and R. Myllyla, Measurement 24, 173 (1998).
  5. K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).
  6. K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).
  7. M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).
  8. I. V. Meglinski and S. J. Matcher, Physiol. Meas. 23, 741 (2002).
  9. W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).
  10. T. L. Troy and S. N. Thennadil, J. Biomed. Opt. 6, 167 (2001).

2004

K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).

M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).

W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).

2003

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

2002

I. V. Meglinski and S. J. Matcher, Physiol. Meas. 23, 741 (2002).

2001

T. L. Troy and S. N. Thennadil, J. Biomed. Opt. 6, 167 (2001).

1999

O. S. Khalil, Clinical Chem. 45, 165 (1999).

S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).

1998

J. Tenhunen, H. Kopola, and R. Myllyla, Measurement 24, 173 (1998).

Arimoto, H.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Arnold, M. A.

M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).

Blank, T. B.

S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).

Chen, W. L.

K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).

W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).

Chin, J.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Cui, H. X.

W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).

Ishii, M.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Jiang, J. Y.

K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).

Khalil, O. S.

O. S. Khalil, Clinical Chem. 45, 165 (1999).

Kopola, H.

J. Tenhunen, H. Kopola, and R. Myllyla, Measurement 24, 173 (1998).

Liu, R.

W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).

Malin, S. F.

S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).

Maruo, K.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Matcher, S. J.

I. V. Meglinski and S. J. Matcher, Physiol. Meas. 23, 741 (2002).

Meglinski, I. V.

I. V. Meglinski and S. J. Matcher, Physiol. Meas. 23, 741 (2002).

Monfre, S. L.

S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).

Murhammer, D. W.

M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).

Myllyla, R.

J. Tenhunen, H. Kopola, and R. Myllyla, Measurement 24, 173 (1998).

Ota, T.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Ozaki, Y.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Qiu, Q. J.

K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).

Qui, J.

M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).

Ruchti, T. L.

S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).

Small, G. W.

M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).

Tamura, M.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Tenhunen, J.

J. Tenhunen, H. Kopola, and R. Myllyla, Measurement 24, 173 (1998).

Thennadil, S. N.

T. L. Troy and S. N. Thennadil, J. Biomed. Opt. 6, 167 (2001).

S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).

Troy, T. L.

T. L. Troy and S. N. Thennadil, J. Biomed. Opt. 6, 167 (2001).

Tsurugi, M.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Xiang, D.

M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).

Xu, K. X.

W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).

K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).

Yamada, Y.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

Anal. Chem.

M. A. Arnold, G. W. Small, D. Xiang, J. Qui, and D. W. Murhammer, Anal. Chem. 76, 2583 (2004).

Clinical Chem.

O. S. Khalil, Clinical Chem. 45, 165 (1999).

S. F. Malin, T. L. Ruchti, T. B. Blank, S. N. Thennadil, and S. L. Monfre, Clinical Chem. 45, 1651 (1999).

IEEE J. Sel. Top. Quantum Electron.

K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. Tamura, M. Ishii, and Y. Ozaki, IEEE J. Sel. Top. Quantum Electron. 9, 322 (2003).

J. Biomed. Opt.

T. L. Troy and S. N. Thennadil, J. Biomed. Opt. 6, 167 (2001).

J. Optoelectron. Laser (in Chinese)

W. L. Chen, R. Liu, H. X. Cui, and K. X. Xu, J. Optoelectron. Laser (in Chinese) 15, 242 (2004).

Measurement

J. Tenhunen, H. Kopola, and R. Myllyla, Measurement 24, 173 (1998).

Physiol. Meas.

I. V. Meglinski and S. J. Matcher, Physiol. Meas. 23, 741 (2002).

Proc. SPIE

K. X. Xu, W. L. Chen, J. Y. Jiang, and Q. J. Qiu, Proc. SPIE 5330, 83 (2004).

Other

Dahne, Claus, Gross, and Daniel, Spectrophotometric method and apparatus for the non-invasive determination of glucose in body tissues US patent 4655225 (April 7, 1987).

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