Abstract

Monitoring the chemical and structural changes in protein side chains and endpoints by infrared (IR) spectroscopy is important for studying the chemical reaction and physical adsorption process of proteins. However, the detection of side chains and endpoints in nanoscale proteins is still challenging due to its weak IR response. Here, by designing a double layered graphene plasmon sensor on MgF₂/Si substrate in the IR fingerprint region, we detect the vibrational modes in side chains and endpoints (1397 cm⁻¹ and 1458 cm⁻¹) of monolayer protein. The sensor could be applied on biochemistry to investigate the physical and chemical reaction of biomolecules.

© 2019 Chinese Laser Press

Mid-infrared sensing of molecular vibrational modes with tunable graphene plasmons

Tingting Wu, Yu Luo, and Lei Wei
Opt. Lett. 42(11) 2066-2069 (2017)

Metasurface with metallic nanoantennas and graphene nanoslits for sensing of protein monolayers and sub-monolayers

Ming Ye and Kenneth B. Crozier
Opt. Express 28(12) 18479-18492 (2020)

Tunable resonant graphene plasmons for mid-infrared biosensing

Tingting Wu and Lei Wei
Opt. Express 24(23) 26241-26248 (2016)

Enhancement sensing of biomarkers by acoustic graphene plasmonic mode

Hang Piao, Qing Chen, Xiangyu Li, Jingzhi Wu, Yanhong Wang, and Mengwei Li
J. Opt. Soc. Am. B 41(3) 571-576 (2024)

Tunable graphene plasmons in nanoribbon arrays: the role of interactions

Oleg Klimenko, Simone Schuler, Andrey Muratov, Vyacheslav Semenenko, Evgeny Gorbachev, Thomas Mueller, and Vasili Perebeinos
Opt. Mater. Express 11(5) 1390-1400 (2021)