Abstract
A reconstruction method guided by early-photon fluorescence yield tomography is
proposed for time-domain fluorescence lifetime tomography (FLT) in this study. The
method employs the early-arriving photons to reconstruct a fluorescence yield map, which
is utilized as a priori information to reconstruct the FLT via all the photons along the
temporal-point spread functions. Phantom experiments demonstrate that, compared with the
method using all the photons for reconstruction of fluorescence yield and lifetime maps,
the proposed method can achieve higher spatial resolution and reduced crosstalk between
different targets without sacrificing the quantification accuracy of lifetime and
contrast between heterogeneous targets.
© 2016 Chinese Laser Press
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