Abstract

Cephalosporins are widely used as veterinary and human antibiotics. However, cephalosporin abuse is harmful to human health and causes allergic reactions or antibiotic resistance. We investigate a method featuring Raman spectroscopy and chemometrics to quantify mixture solutions of three typical cephalosporins, namely, ceftriaxone, cefotaxime sodium, and cefazolin sodium. Partial least-squares regression models are built on spectral data that are preprocessed by various methods. With prediction relative errors within 5% and high correlation coefficients of 0.998, we demonstrate that Raman spectroscopy combined with multivariate analysis is feasible for use in the quantitative determination of cephalosporin solutions.

© 2013 Chinese Optics Letters

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