Abstract

Cephalosporins are widely used as veterinary and human antibiotics. However, cephalosporin abuse is harmful to human health and causes allergic reactions or antibiotic resistance. We investigate a method featuring Raman spectroscopy and chemometrics to quantify mixture solutions of three typical cephalosporins, namely, ceftriaxone, cefotaxime sodium, and cefazolin sodium. Partial least-squares regression models are built on spectral data that are preprocessed by various methods. With prediction relative errors within 5% and high correlation coefficients of 0.998, we demonstrate that Raman spectroscopy combined with multivariate analysis is feasible for use in the quantitative determination of cephalosporin solutions.

© 2013 Chinese Optics Letters

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2013

9 Y. J. Ding and J. B. Khurgin, Chin. Opt. Lett. 11, 011901 (2013).

13 P. Li, H. L. Yin, and Y. Zhang, China Pharmacist. 16, 346 (2013).

2011

2009

1 K. K¨ummerer, Chemosphere 75, 417 (2009).

12 J. W. Peterson, T. A. O'Meara, M. D. Seymour, W. Wang, and B. Gu, Environmental Pollution. 157, 1849 (2009).

2008

3 B. B. Koleva, T. M. Kolev, and M. Spiteller, J. Pharm. Biomed. Anal. 48, 201 (2008).

2005

10 S. J. Clarke, R. E. Littleford, W. E. Smith, and R. Goodacre, Analyst. 130, 1019 (2005).

2003

5 B. Morelli, J. Pharm. Biomed. Anal. 32, 257 (2003).

2002

6 F. Rull, Pure Appl. Chem. 74, 1859 (2002).

1999

11 O. Svensson, M. Josefson, and F. W. Langkilde, Chemometr. Intell. Lab. 49, 49 (1999).

16 W. Wu, Q. Guo, D. Jouan-Rimbaud, and D. L. Massart, Chemometr. Intell. Lab. Sys. 45, 39 (1999)

1998

17 S. Wold, H. Antti, F. Lindgren, and J. Ohman, Chemometr. Intell. Lab. Sys. 44, 175 (1998).

1990

2 B. M. Tune and C. Hsu, J. Am. Soc. Nephrol. 1, 815 (1990).

1989

1988

4 B. Morelli, Analyst. 113, 1077 (1988).

1985

Antti, H.

17 S. Wold, H. Antti, F. Lindgren, and J. Ohman, Chemometr. Intell. Lab. Sys. 44, 175 (1998).

Barnes, 15 R. J.

Cheng, H.

Clarke, 10 S. J.

10 S. J. Clarke, R. E. Littleford, W. E. Smith, and R. Goodacre, Analyst. 130, 1019 (2005).

Dhanoa, M. S.

Ding, 9 Y. J.

Gan, F.

Geladi, 14 P.

Goodacre, R.

10 S. J. Clarke, R. E. Littleford, W. E. Smith, and R. Goodacre, Analyst. 130, 1019 (2005).

Gu, B.

12 J. W. Peterson, T. A. O'Meara, M. D. Seymour, W. Wang, and B. Gu, Environmental Pollution. 157, 1849 (2009).

Guo, L.

Guo, Q.

16 W. Wu, Q. Guo, D. Jouan-Rimbaud, and D. L. Massart, Chemometr. Intell. Lab. Sys. 45, 39 (1999)

Hsu, C.

2 B. M. Tune and C. Hsu, J. Am. Soc. Nephrol. 1, 815 (1990).

Josefson, M.

11 O. Svensson, M. Josefson, and F. W. Langkilde, Chemometr. Intell. Lab. 49, 49 (1999).

Jouan-Rimbaud, D.

16 W. Wu, Q. Guo, D. Jouan-Rimbaud, and D. L. Massart, Chemometr. Intell. Lab. Sys. 45, 39 (1999)

K¨ummerer, 1 K.

1 K. K¨ummerer, Chemosphere 75, 417 (2009).

Khurgin, J. B.

Kolev, T. M.

3 B. B. Koleva, T. M. Kolev, and M. Spiteller, J. Pharm. Biomed. Anal. 48, 201 (2008).

Koleva, 3 B. B.

3 B. B. Koleva, T. M. Kolev, and M. Spiteller, J. Pharm. Biomed. Anal. 48, 201 (2008).

Langkilde, F. W.

11 O. Svensson, M. Josefson, and F. W. Langkilde, Chemometr. Intell. Lab. 49, 49 (1999).

Li, 13 P.

13 P. Li, H. L. Yin, and Y. Zhang, China Pharmacist. 16, 346 (2013).

Li, L.

Li, Q.

Lindgren, F.

17 S. Wold, H. Antti, F. Lindgren, and J. Ohman, Chemometr. Intell. Lab. Sys. 44, 175 (1998).

Lister, S. J.

Littleford, R. E.

10 S. J. Clarke, R. E. Littleford, W. E. Smith, and R. Goodacre, Analyst. 130, 1019 (2005).

MacDougall, D.

Martens, H.

Massart, D. L.

16 W. Wu, Q. Guo, D. Jouan-Rimbaud, and D. L. Massart, Chemometr. Intell. Lab. Sys. 45, 39 (1999)

Morelli, 4 B.

4 B. Morelli, Analyst. 113, 1077 (1988).

Morelli, 5 B.

5 B. Morelli, J. Pharm. Biomed. Anal. 32, 257 (2003).

Ohman, J.

17 S. Wold, H. Antti, F. Lindgren, and J. Ohman, Chemometr. Intell. Lab. Sys. 44, 175 (1998).

O'Meara, T. A.

12 J. W. Peterson, T. A. O'Meara, M. D. Seymour, W. Wang, and B. Gu, Environmental Pollution. 157, 1849 (2009).

Peterson, 12 J. W.

12 J. W. Peterson, T. A. O'Meara, M. D. Seymour, W. Wang, and B. Gu, Environmental Pollution. 157, 1849 (2009).

Rull, 6 F.

6 F. Rull, Pure Appl. Chem. 74, 1859 (2002).

Seymour, M. D.

12 J. W. Peterson, T. A. O'Meara, M. D. Seymour, W. Wang, and B. Gu, Environmental Pollution. 157, 1849 (2009).

Smith, W. E.

10 S. J. Clarke, R. E. Littleford, W. E. Smith, and R. Goodacre, Analyst. 130, 1019 (2005).

Spiteller, M.

3 B. B. Koleva, T. M. Kolev, and M. Spiteller, J. Pharm. Biomed. Anal. 48, 201 (2008).

Svensson, 11 O.

11 O. Svensson, M. Josefson, and F. W. Langkilde, Chemometr. Intell. Lab. 49, 49 (1999).

Tan, 7 E.

Tune, 2 B. M.

2 B. M. Tune and C. Hsu, J. Am. Soc. Nephrol. 1, 815 (1990).

Wang, W.

12 J. W. Peterson, T. A. O'Meara, M. D. Seymour, W. Wang, and B. Gu, Environmental Pollution. 157, 1849 (2009).

Wold, 17 S.

17 S. Wold, H. Antti, F. Lindgren, and J. Ohman, Chemometr. Intell. Lab. Sys. 44, 175 (1998).

Wu, 16 W.

16 W. Wu, Q. Guo, D. Jouan-Rimbaud, and D. L. Massart, Chemometr. Intell. Lab. Sys. 45, 39 (1999)

Yin, H. L.

13 P. Li, H. L. Yin, and Y. Zhang, China Pharmacist. 16, 346 (2013).

Yin, P.

Zhang, Y.

13 P. Li, H. L. Yin, and Y. Zhang, China Pharmacist. 16, 346 (2013).

Zhao, 8 H.

Analyst.

4 B. Morelli, Analyst. 113, 1077 (1988).

10 S. J. Clarke, R. E. Littleford, W. E. Smith, and R. Goodacre, Analyst. 130, 1019 (2005).

Appl. Spectrosc.

Chemometr. Intell. Lab.

11 O. Svensson, M. Josefson, and F. W. Langkilde, Chemometr. Intell. Lab. 49, 49 (1999).

Chemometr. Intell. Lab. Sys.

16 W. Wu, Q. Guo, D. Jouan-Rimbaud, and D. L. Massart, Chemometr. Intell. Lab. Sys. 45, 39 (1999)

17 S. Wold, H. Antti, F. Lindgren, and J. Ohman, Chemometr. Intell. Lab. Sys. 44, 175 (1998).

Chemosphere

1 K. K¨ummerer, Chemosphere 75, 417 (2009).

Chin. Opt. Lett.

China Pharmacist.

13 P. Li, H. L. Yin, and Y. Zhang, China Pharmacist. 16, 346 (2013).

Environmental Pollution.

12 J. W. Peterson, T. A. O'Meara, M. D. Seymour, W. Wang, and B. Gu, Environmental Pollution. 157, 1849 (2009).

J. Am. Soc. Nephrol.

2 B. M. Tune and C. Hsu, J. Am. Soc. Nephrol. 1, 815 (1990).

J. Pharm. Biomed. Anal.

3 B. B. Koleva, T. M. Kolev, and M. Spiteller, J. Pharm. Biomed. Anal. 48, 201 (2008).

5 B. Morelli, J. Pharm. Biomed. Anal. 32, 257 (2003).

Pure Appl. Chem.

6 F. Rull, Pure Appl. Chem. 74, 1859 (2002).

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