Abstract

Digital radiography (DR) and whole-body fluorescent optical imaging (WFOI) have been widely applied in the field of molecular imaging, with the advantages in tissues and functional imaging. The integration of them contributes to the development and discovery of medicine. We introduce an equipment, performance of which is better than that of another molecular imaging system manufactured by Kodak Corp. It can take real-time small animal imaging in vivo, with lower cost and shorter development cycle on the LabVIEW platform. At last, a paradigm experiment on a nude mouse with green fluorescent protein (GFP) transgenic tumor is given to present a real-time DR-WFOI fusion simultaneous image.

© 2008 Chinese Optics Letters

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  1. R. Weissleder and V. Ntziachristos, Nature Medicine 9, 123 (2003).
  2. V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, Jr., L. Josephson, and R. Weissleder, in Proceedings of the National Academy of Sciences 101, 12294 (2004).
  3. M. Yang, E. Baranov, X.-M. Li, J. Wang, P. Jiang, L. Li, A. R. Moossa, S. Penman, and R. M. Hoffman, in Proceedings of the National Academy of Sciences of the United States of America 98, 2616 (2001).
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  7. R. M. Hoffman, Lancet Oncol. 3, 546 (2002).
  8. T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).
  9. R. Weissleder and U. Mahmood, Radiology 219, 316 (2001).
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  11. C. A. Carlsson, Physics in Medicine and Biology 44, 23 (1999).
  12. G. Wang and M. Vannier, Advanced Imaging 16, 18 (2001).

2003

R. Weissleder and V. Ntziachristos, Nature Medicine 9, 123 (2003).

2002

R. Weissleder, Nature Reviews Cancer 2, 11 (2002).

R. M. Hoffman, Lancet Oncol. 3, 546 (2002).

2001

R. Weissleder and U. Mahmood, Radiology 219, 316 (2001).

G. Wang and M. Vannier, Advanced Imaging 16, 18 (2001).

2000

C. H. Contag, D. Jenkins, P. R. Contag, and R. S. Negrin, Neoplasia 2, 41 (2000).

1999

C. A. Carlsson, Physics in Medicine and Biology 44, 23 (1999).

1997

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

1996

L. Cheng, J. Fu, A. Tsukamoto, and R. G. Hawley, Nature Biotechnology 14, 606 (1996).

Baranov, E.

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Carlsson, C. A.

C. A. Carlsson, Physics in Medicine and Biology 44, 23 (1999).

Cheng, L.

L. Cheng, J. Fu, A. Tsukamoto, and R. G. Hawley, Nature Biotechnology 14, 606 (1996).

Chishima, T.

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Contag, C. H.

C. H. Contag, D. Jenkins, P. R. Contag, and R. S. Negrin, Neoplasia 2, 41 (2000).

Contag, P. R.

C. H. Contag, D. Jenkins, P. R. Contag, and R. S. Negrin, Neoplasia 2, 41 (2000).

Fu, J.

L. Cheng, J. Fu, A. Tsukamoto, and R. G. Hawley, Nature Biotechnology 14, 606 (1996).

Hawley, R. G.

L. Cheng, J. Fu, A. Tsukamoto, and R. G. Hawley, Nature Biotechnology 14, 606 (1996).

Hoffman, R. M.

R. M. Hoffman, Lancet Oncol. 3, 546 (2002).

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Jenkins, D.

C. H. Contag, D. Jenkins, P. R. Contag, and R. S. Negrin, Neoplasia 2, 41 (2000).

Mahmood, U.

R. Weissleder and U. Mahmood, Radiology 219, 316 (2001).

Miyagi, Y.

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Moossa, A. R.

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Negrin, R. S.

C. H. Contag, D. Jenkins, P. R. Contag, and R. S. Negrin, Neoplasia 2, 41 (2000).

Ntziachristos, V.

R. Weissleder and V. Ntziachristos, Nature Medicine 9, 123 (2003).

Shimada, H.

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Tan, Y.

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Tsukamoto, A.

L. Cheng, J. Fu, A. Tsukamoto, and R. G. Hawley, Nature Biotechnology 14, 606 (1996).

Vannier, M.

G. Wang and M. Vannier, Advanced Imaging 16, 18 (2001).

Wang, G.

G. Wang and M. Vannier, Advanced Imaging 16, 18 (2001).

Wang, X.

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Weissleder, R.

R. Weissleder and V. Ntziachristos, Nature Medicine 9, 123 (2003).

R. Weissleder, Nature Reviews Cancer 2, 11 (2002).

R. Weissleder and U. Mahmood, Radiology 219, 316 (2001).

Advanced Imaging

G. Wang and M. Vannier, Advanced Imaging 16, 18 (2001).

Clinical and Experimental Metastasis

T. Chishima, Y. Miyagi, X. Wang, E. Baranov, Y. Tan, H. Shimada, A. R. Moossa, and R. M. Hoffman, Clinical and Experimental Metastasis 15, 547 (1997).

Lancet Oncol.

R. M. Hoffman, Lancet Oncol. 3, 546 (2002).

Nature Biotechnology

L. Cheng, J. Fu, A. Tsukamoto, and R. G. Hawley, Nature Biotechnology 14, 606 (1996).

Nature Medicine

R. Weissleder and V. Ntziachristos, Nature Medicine 9, 123 (2003).

Nature Reviews Cancer

R. Weissleder, Nature Reviews Cancer 2, 11 (2002).

Neoplasia

C. H. Contag, D. Jenkins, P. R. Contag, and R. S. Negrin, Neoplasia 2, 41 (2000).

Physics in Medicine and Biology

C. A. Carlsson, Physics in Medicine and Biology 44, 23 (1999).

Radiology

R. Weissleder and U. Mahmood, Radiology 219, 316 (2001).

Other

J. M. Boone, Handbook of Medical Imaging J. Beutel (ed.) H. L. Kundel, R. L. Van Metter (trans.) (SPIE Press, Bellingham, 2000) pp.1-78

V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, A. Bogdanov, Jr., L. Josephson, and R. Weissleder, in Proceedings of the National Academy of Sciences 101, 12294 (2004).

M. Yang, E. Baranov, X.-M. Li, J. Wang, P. Jiang, L. Li, A. R. Moossa, S. Penman, and R. M. Hoffman, in Proceedings of the National Academy of Sciences of the United States of America 98, 2616 (2001).

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