Abstract

Digital holographic microscopy is the state of the art quantitative phase imaging of micro-objects including living cells. It is an ideal tool to image and quantify cell thickness profiles with nanometer thickness resolution. Digital holographic techniques usually are implemented using a two-beam setup that may be bulky and may not be field portable. Self-referencing techniques provide compact geometry but suffer from a reduction of the field of view. Here, we discuss the development of a wavefront division digital holographic microscope providing the full field of view with a compact system. The proposed approach uses a wavefront division module consisting of two lenses. The developed microscope is tested experimentally by measuring the physical and mechanical properties of red blood cells.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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    [Crossref] [PubMed]
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2017 (3)

A. Anand, I. Moon, and B. Javidi, “Automated Disease Identification with 3D Optical Imaging: a medical diagnostic tool,” Proc. IEEE 105(5), 924–946 (2017).
[Crossref]

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

2015 (1)

2014 (1)

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

2012 (3)

2011 (4)

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

A. Anand, V. K. Chhaniwal, and B. Javidi, “Imaging embryonic stem cell dynamics using quantitative 3D digital holographic microscopy,” IEEE Photonics J. 3(3), 546–554 (2011).
[Crossref]

M. Mir, K. Tangella, and G. Popescu, “Blood testing at the single cell level using quantitative phase and amplitude microscopy,” Biomed. Opt. Express 2(12), 3259–3266 (2011).
[Crossref] [PubMed]

B. Kemper, A. Vollmer, C. E. Rommel, J. Schnekenburger, and G. von Bally, “Simplified approach for quantitative digital holographic phase contrast imaging of living cells,” J. Biomed. Opt. 16(2), 026014 (2011).
[Crossref] [PubMed]

2010 (4)

G. Coppola, G. Di Caprio, M. Gioffré, R. Puglisi, D. Balduzzi, A. Galli, L. Miccio, M. Paturzo, S. Grilli, A. Finizio, and P. Ferraro, “Digital self-referencing quantitative phase microscopy by wavefront folding in holographic image reconstruction,” Opt. Lett. 35(20), 3390–3392 (2010).
[Crossref] [PubMed]

N. T. Shaked, L. L. Satterwhite, N. Bursac, and A. Wax, “Whole-cell-analysis of live cardiomyocytes using wide-field interferometric phase microscopy,” Biomed. Opt. Express 1(2), 706–719 (2010).
[Crossref] [PubMed]

A. Anand, V. Chhaniwal, and B. Javidi, “Real-time digital holographic microscopy for phase contrast 3D imaging of dynamic phenomena,” IEEE J. Disp. Technol. 6(10), 500–505 (2010).
[Crossref]

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

2009 (1)

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

2008 (1)

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

2006 (2)

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

G. Popescu, A. K. Badizadegan, R. R. Dasari, and M. S. Feld, “Observation of dynamic subdomains in red blood cells,” J. Biomed. Opt. 11, 040503 (2006).

2005 (1)

1998 (1)

1955 (1)

G. Nomarski, “Microinterférométrie differential et ondes polarizés,” J. Phys. Radium 16, 9–135 (1955).

1942 (1)

F. Zernike, “Phase contrast, a new method for microscopic observation of transparent objects,” Physica 9(7), 686–698 (1942).
[Crossref]

Anand, A.

A. Anand, I. Moon, and B. Javidi, “Automated Disease Identification with 3D Optical Imaging: a medical diagnostic tool,” Proc. IEEE 105(5), 924–946 (2017).
[Crossref]

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

A. S. Singh, A. Anand, R. A. Leitgeb, and B. Javidi, “Lateral shearing digital holographic imaging of small biological specimens,” Opt. Express 20(21), 23617–23622 (2012).
[Crossref] [PubMed]

A. Anand, V. K. Chhaniwal, N. Patel, and B. Javidi, “Automatic identification of malaria infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[Crossref]

A. Anand, V. K. Chhaniwal, and B. Javidi, “Imaging embryonic stem cell dynamics using quantitative 3D digital holographic microscopy,” IEEE Photonics J. 3(3), 546–554 (2011).
[Crossref]

A. Anand, V. Chhaniwal, and B. Javidi, “Real-time digital holographic microscopy for phase contrast 3D imaging of dynamic phenomena,” IEEE J. Disp. Technol. 6(10), 500–505 (2010).
[Crossref]

Badizadegan, A. K.

G. Popescu, A. K. Badizadegan, R. R. Dasari, and M. S. Feld, “Observation of dynamic subdomains in red blood cells,” J. Biomed. Opt. 11, 040503 (2006).

Balduzzi, D.

Barbul, A.

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

Bauwens, A.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Bianco, V.

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

Bursac, N.

Cano, E.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

Chhaniwal, V.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

A. Anand, V. Chhaniwal, and B. Javidi, “Real-time digital holographic microscopy for phase contrast 3D imaging of dynamic phenomena,” IEEE J. Disp. Technol. 6(10), 500–505 (2010).
[Crossref]

Chhaniwal, V. K.

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

A. Anand, V. K. Chhaniwal, N. Patel, and B. Javidi, “Automatic identification of malaria infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[Crossref]

A. Anand, V. K. Chhaniwal, and B. Javidi, “Imaging embryonic stem cell dynamics using quantitative 3D digital holographic microscopy,” IEEE Photonics J. 3(3), 546–554 (2011).
[Crossref]

Colomb, T.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30(5), 468–470 (2005).
[Crossref] [PubMed]

Coppola, G.

Coppola, S.

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

Cuche, E.

Dasari, R. R.

G. Popescu, A. K. Badizadegan, R. R. Dasari, and M. S. Feld, “Observation of dynamic subdomains in red blood cells,” J. Biomed. Opt. 11, 040503 (2006).

Debeir, O.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Decaestecker, C.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Depeursinge, C.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30(5), 468–470 (2005).
[Crossref] [PubMed]

Di Caprio, G.

Distante, C.

Dubey, S. K.

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

Dubois, F.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Emery, Y.

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30(5), 468–470 (2005).
[Crossref] [PubMed]

Faridian, A.

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

Feld, M. S.

G. Popescu, A. K. Badizadegan, R. R. Dasari, and M. S. Feld, “Observation of dynamic subdomains in red blood cells,” J. Biomed. Opt. 11, 040503 (2006).

Ferraro, P.

Finizio, A.

Galli, A.

Gioffré, M.

Grilli, S.

Hammer, M.

Javidi, B.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

A. Anand, I. Moon, and B. Javidi, “Automated Disease Identification with 3D Optical Imaging: a medical diagnostic tool,” Proc. IEEE 105(5), 924–946 (2017).
[Crossref]

B. Rappaz, I. Moon, F. Yi, B. Javidi, P. Marquet, and G. Turcatti, “Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy,” Opt. Express 23(10), 13333–13347 (2015).
[Crossref] [PubMed]

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

A. S. Singh, A. Anand, R. A. Leitgeb, and B. Javidi, “Lateral shearing digital holographic imaging of small biological specimens,” Opt. Express 20(21), 23617–23622 (2012).
[Crossref] [PubMed]

A. Anand, V. K. Chhaniwal, N. Patel, and B. Javidi, “Automatic identification of malaria infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[Crossref]

A. Anand, V. K. Chhaniwal, and B. Javidi, “Imaging embryonic stem cell dynamics using quantitative 3D digital holographic microscopy,” IEEE Photonics J. 3(3), 546–554 (2011).
[Crossref]

A. Anand, V. Chhaniwal, and B. Javidi, “Real-time digital holographic microscopy for phase contrast 3D imaging of dynamic phenomena,” IEEE J. Disp. Technol. 6(10), 500–505 (2010).
[Crossref]

Joglekar, M.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

Karch, H.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Kemper, B.

B. Kemper, A. Vollmer, C. E. Rommel, J. Schnekenburger, and G. von Bally, “Simplified approach for quantitative digital holographic phase contrast imaging of living cells,” J. Biomed. Opt. 16(2), 026014 (2011).
[Crossref] [PubMed]

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Ketelhut, S.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Kiss, R.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Kolb, A.

Korenstein, R.

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

Kühn, J.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

Langehanenberg, P.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Legros, J. C.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Leitgeb, R. A.

Magistretti, P. J.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30(5), 468–470 (2005).
[Crossref] [PubMed]

Mahajan, S.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

Mandracchia, B.

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

Marchesano, V.

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

Marquet, P.

B. Rappaz, I. Moon, F. Yi, B. Javidi, P. Marquet, and G. Turcatti, “Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy,” Opt. Express 23(10), 13333–13347 (2015).
[Crossref] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30(5), 468–470 (2005).
[Crossref] [PubMed]

Memmolo, P.

Miccio, L.

Michel, B.

Mir, M.

Monnom, O.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Moon, I.

Moradi, A. R.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

Müthing, J.

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Nomarski, G.

G. Nomarski, “Microinterférométrie differential et ondes polarizés,” J. Phys. Radium 16, 9–135 (1955).

Olivieri, F.

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

Osten, W.

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

Pagliarulo, V.

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

Patel, N.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

A. Anand, V. K. Chhaniwal, N. Patel, and B. Javidi, “Automatic identification of malaria infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[Crossref]

Paturzo, M.

Pedrini, G.

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

Popescu, G.

M. Mir, K. Tangella, and G. Popescu, “Blood testing at the single cell level using quantitative phase and amplitude microscopy,” Biomed. Opt. Express 2(12), 3259–3266 (2011).
[Crossref] [PubMed]

G. Popescu, A. K. Badizadegan, R. R. Dasari, and M. S. Feld, “Observation of dynamic subdomains in red blood cells,” J. Biomed. Opt. 11, 040503 (2006).

Puglisi, R.

Rappaz, B.

B. Rappaz, I. Moon, F. Yi, B. Javidi, P. Marquet, and G. Turcatti, “Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy,” Opt. Express 23(10), 13333–13347 (2015).
[Crossref] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

P. Marquet, B. Rappaz, P. J. Magistretti, E. Cuche, Y. Emery, T. Colomb, and C. Depeursinge, “Digital holographic microscopy: a noninvasive contrast imaging technique allowing quantitative visualization of living cells with subwavelength axial accuracy,” Opt. Lett. 30(5), 468–470 (2005).
[Crossref] [PubMed]

Rommel, C. E.

B. Kemper, A. Vollmer, C. E. Rommel, J. Schnekenburger, and G. von Bally, “Simplified approach for quantitative digital holographic phase contrast imaging of living cells,” J. Biomed. Opt. 16(2), 026014 (2011).
[Crossref] [PubMed]

Satterwhite, L. L.

Schnekenburger, J.

B. Kemper, A. Vollmer, C. E. Rommel, J. Schnekenburger, and G. von Bally, “Simplified approach for quantitative digital holographic phase contrast imaging of living cells,” J. Biomed. Opt. 16(2), 026014 (2011).
[Crossref] [PubMed]

Schweitzer, D.

Shaked, N. T.

Simanis, V.

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

Singh, A. S.

Tangella, K.

Thamm, E.

Trivedi, V.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

Turcatti, G.

Van Ham, P.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Vollmer, A.

B. Kemper, A. Vollmer, C. E. Rommel, J. Schnekenburger, and G. von Bally, “Simplified approach for quantitative digital holographic phase contrast imaging of living cells,” J. Biomed. Opt. 16(2), 026014 (2011).
[Crossref] [PubMed]

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

von Bally, G.

B. Kemper, A. Vollmer, C. E. Rommel, J. Schnekenburger, and G. von Bally, “Simplified approach for quantitative digital holographic phase contrast imaging of living cells,” J. Biomed. Opt. 16(2), 026014 (2011).
[Crossref] [PubMed]

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

Vora, P.

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

Wax, A.

Yi, F.

Yourassowsky, C.

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

Zernike, F.

F. Zernike, “Phase contrast, a new method for microscopic observation of transparent objects,” Physica 9(7), 686–698 (1942).
[Crossref]

Appl. Opt. (1)

Appl. Phys. Lett. (1)

A. Anand, A. Faridian, V. K. Chhaniwal, S. Mahajan, V. Trivedi, S. K. Dubey, G. Pedrini, W. Osten, and B. Javidi, “Single Beam Fourier Transform Digital Holographic Quantitative Phase Microscopy,” Appl. Phys. Lett. 104(10), 103705 (2014).
[Crossref]

Biomed. Opt. Express (2)

Cytometry A (1)

B. Rappaz, A. Barbul, Y. Emery, R. Korenstein, C. Depeursinge, P. J. Magistretti, and P. Marquet, “Comparative study of human erythrocytes by digital holographic microscopy, confocal microscopy, and impedance volume analyzer,” Cytometry A 73(10), 895–903 (2008).
[Crossref] [PubMed]

IEEE J. Disp. Technol. (1)

A. Anand, V. Chhaniwal, and B. Javidi, “Real-time digital holographic microscopy for phase contrast 3D imaging of dynamic phenomena,” IEEE J. Disp. Technol. 6(10), 500–505 (2010).
[Crossref]

IEEE Photonics J. (2)

A. Anand, V. K. Chhaniwal, N. Patel, and B. Javidi, “Automatic identification of malaria infected RBC with digital holographic microscopy using correlation algorithms,” IEEE Photonics J. 4(5), 1456–1464 (2012).
[Crossref]

A. Anand, V. K. Chhaniwal, and B. Javidi, “Imaging embryonic stem cell dynamics using quantitative 3D digital holographic microscopy,” IEEE Photonics J. 3(3), 546–554 (2011).
[Crossref]

J. Biomed. Opt. (6)

G. Popescu, A. K. Badizadegan, R. R. Dasari, and M. S. Feld, “Observation of dynamic subdomains in red blood cells,” J. Biomed. Opt. 11, 040503 (2006).

B. Kemper, A. Bauwens, A. Vollmer, S. Ketelhut, P. Langehanenberg, J. Müthing, H. Karch, and G. von Bally, “Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy,” J. Biomed. Opt. 15(3), 036009 (2010).
[Crossref] [PubMed]

B. Rappaz, E. Cano, T. Colomb, J. Kühn, C. Depeursinge, V. Simanis, P. J. Magistretti, and P. Marquet, “Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy,” J. Biomed. Opt. 14(3), 034049 (2009).
[Crossref] [PubMed]

F. Dubois, C. Yourassowsky, O. Monnom, J. C. Legros, O. Debeir, P. Van Ham, R. Kiss, and C. Decaestecker, “Digital holographic microscopy for the three-dimensional dynamic analysis of in vitro cancer cell migration,” J. Biomed. Opt. 11(5), 054032 (2006).
[Crossref] [PubMed]

P. Vora, V. Trivedi, S. Mahajan, N. Patel, M. Joglekar, V. Chhaniwal, A. R. Moradi, B. Javidi, and A. Anand, “Wide field of view common-path lateral-shearing digital holographic interference microscope,” J. Biomed. Opt. 22(12), 1–11 (2017).
[PubMed]

B. Kemper, A. Vollmer, C. E. Rommel, J. Schnekenburger, and G. von Bally, “Simplified approach for quantitative digital holographic phase contrast imaging of living cells,” J. Biomed. Opt. 16(2), 026014 (2011).
[Crossref] [PubMed]

J. Phys. Radium (1)

G. Nomarski, “Microinterférométrie differential et ondes polarizés,” J. Phys. Radium 16, 9–135 (1955).

Light Sci. Appl. (1)

V. Bianco, B. Mandracchia, V. Marchesano, V. Pagliarulo, F. Olivieri, S. Coppola, M. Paturzo, and P. Ferraro, “Endowing a plain fluidic chip with micro-optics: a holographic microscope slide,” Light Sci. Appl. 6(9), e17055 (2017).
[Crossref]

Opt. Express (3)

Opt. Lett. (3)

Physica (1)

F. Zernike, “Phase contrast, a new method for microscopic observation of transparent objects,” Physica 9(7), 686–698 (1942).
[Crossref]

Proc. IEEE (1)

A. Anand, I. Moon, and B. Javidi, “Automated Disease Identification with 3D Optical Imaging: a medical diagnostic tool,” Proc. IEEE 105(5), 924–946 (2017).
[Crossref]

Other (2)

D. B. Murphy, Fundamentals of Light Microscopy and Electronic Imaging (Wiley-Liss, 2001).

P. Ferraro, A. Wax, and Z. Zalevsky, Coherent Light Microscopy: Imaging and Quantitative Phase Analysis (Springer, 2011).

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Figures (5)

Fig. 1
Fig. 1 (a) Wavefront division digital holographic microscope. (b) Wavefront division module. (c) Conversion of incident laser beam into object and reference wavefronts.
Fig. 2
Fig. 2 (a) Quantitative phase image of the polystyrene microspheres obtained after thresholding the phase map. (b) Reconstructed thickness profile of the microsphere obtained by plugging the quantitative phase information shown in Fig. 2(a) into Eq. (1). (c) Cross-sectional thickness profile of the polystyrene microspheres along the line shown in Fig. 2(a).
Fig. 3
Fig. 3 (a) Recorded hologram of human red blood cells. (b) Reconstructed intensity pattern of the human red blood cells. (c) Quantitative phase image (d). Thickness profile of blood cells inside the region of interest shown in Fig. 3(c).
Fig. 4
Fig. 4 (a) Thickness fluctuation of red blood cells. (b) Peak frequency of thickness fluctuation. Inset shows three dimensional rendering of the amplitude of thickness fluctuation as well as its frequency for the cell inside the rectangle.
Fig. 5
Fig. 5 Computed cell parameter distributions. (a) Mean cell thickness. (b) Cell volume. (c) Surface Area to Volume ratio.

Equations (1)

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Δϕ( x,y,t )= 2π λ ( n O n R )h( x,y,t ).

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