Abstract

The combination of optical resolution photoacoustic microscopy (ORPAM) and optical coherence tomography (OCT) is capable of providing complementary imaging contrasts. Unfortunately, the miniaturization of ORPAM remains a major challenge in the development of a handheld dual-modality imaging microscope with OCT. Here, we report the design and evaluation of an integrated ORPAM and OCT imaging probe using a two-dimensional MEMS (micro-electro-mechanical-system)-based optical scanner. This microscope, weighting 35.4 g, has an ultracompact size of 65×30×18 mm3, and an effective imaging area of 2×2 mm2. The experimental lateral resolutions are 3.7 μm (ORPAM) and 5.6 μm (OCT), and the axial resolutions are measured as 120 μm (ORPAM) and 7.3 μm (OCT). Besides phantom and animal experiments, we carried out oral imaging of a healthy volunteer to show the clinical feasibility of this technique.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2018 (1)

2017 (3)

T. Jin, H. Guo, H. Jiang, B. Ke, and L. Xi, “Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging,” Opt. Lett. 42(21), 4434–4437 (2017).
[Crossref] [PubMed]

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, “Inverted multiscale optical resolution photoacoustic microscopy,” J. Biophotonics 10(12), 1580–1585 (2017).
[Crossref] [PubMed]

W. Qin, W. Qi, T. Jin, H. Guo, and L. Xi, “In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography,” Appl. Phys. Lett. 111(26), 263704 (2017).
[Crossref]

2016 (1)

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

2015 (2)

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

B. Zabihian, J. Weingast, M. Liu, E. Zhang, P. Beard, H. Pehamberger, W. Drexler, and B. Hermann, “In vivo dual-modality photoacoustic and optical coherence tomography imaging of human dermatological pathologies,” Biomed. Opt. Express 6(9), 3163–3178 (2015).
[Crossref] [PubMed]

2014 (1)

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

2013 (1)

2012 (3)

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

X. Zhang, H. F. Zhang, and S. Jiao, “Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source,” J. Biomed. Opt. 17(3), 030502 (2012).
[Crossref] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

2011 (3)

2010 (4)

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

L. Li, B. Rao, K. Maslov, and L. V. Wang, “Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy,” Proc. SPIE 7564, 75641Z (2010).
[Crossref]

2009 (2)

C. Y. L. Chao and G. L. Y. Cheing, “Microvascular dysfunction in diabetic foot disease and ulceration,” Diabetes Metab. Res. Rev. 25(7), 604–614 (2009).
[Crossref] [PubMed]

Z. Xie, S. Jiao, H. F. Zhang, and C. A. Puliafito, “Laser-scanning optical-resolution photoacoustic microscopy,” Opt. Lett. 34(12), 1771–1773 (2009).
[Crossref] [PubMed]

2008 (1)

2006 (1)

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

2005 (1)

M. F. O’Rourke and M. E. Safar, “Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy,” Hypertension 46(1), 200–204 (2005).
[Crossref] [PubMed]

2004 (3)

2003 (3)

2001 (1)

Alex, A.

Antoch, G.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Barkhausen, J.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Beard, P.

Bockisch, A.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Bouma, B. E.

Burke, J. M.

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

Burnett, J.

Cai, X.

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

Cense, B.

Chang, C. C.

Chao, C. Y. L.

C. Y. L. Chao and G. L. Y. Cheing, “Microvascular dysfunction in diabetic foot disease and ulceration,” Diabetes Metab. Res. Rev. 25(7), 604–614 (2009).
[Crossref] [PubMed]

Cheing, G. L. Y.

C. Y. L. Chao and G. L. Y. Cheing, “Microvascular dysfunction in diabetic foot disease and ulceration,” Diabetes Metab. Res. Rev. 25(7), 604–614 (2009).
[Crossref] [PubMed]

Chen, H. M.

Chen, S. L.

Chen, T. C.

Chiang, C. P.

Choi, K.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Choma, M.

Cox, B.

Creteur, J.

D. De Backer, J. Creteur, M. J. Dubois, Y. Sakr, and J. L. Vincent, “Microvascular alterations in patients with acute severe heart failure and cardiogenic shock,” Am. Heart J. 147(1), 91–99 (2004).
[Crossref] [PubMed]

Dahmen, G.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

De Backer, D.

D. De Backer, J. Creteur, M. J. Dubois, Y. Sakr, and J. L. Vincent, “Microvascular alterations in patients with acute severe heart failure and cardiogenic shock,” Am. Heart J. 147(1), 91–99 (2004).
[Crossref] [PubMed]

de Boer, J. F.

Debatin, J. F.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Drexler, W.

Dubois, M. J.

D. De Backer, J. Creteur, M. J. Dubois, Y. Sakr, and J. L. Vincent, “Microvascular alterations in patients with acute severe heart failure and cardiogenic shock,” Am. Heart J. 147(1), 91–99 (2004).
[Crossref] [PubMed]

DuBose, T.

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

Duker, J.

Eleftheriadis, N.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Farsiu, S.

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

Favazza, C.

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

Fercher, A.

Freudenberg, L. S.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Fujimoto, J.

Glittenberg, C.

Goehde, S. C.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Guo, H.

T. Jin, H. Guo, H. Jiang, B. Ke, and L. Xi, “Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging,” Opt. Lett. 42(21), 4434–4437 (2017).
[Crossref] [PubMed]

W. Qin, W. Qi, T. Jin, H. Guo, and L. Xi, “In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography,” Appl. Phys. Lett. 111(26), 263704 (2017).
[Crossref]

Han, M. H.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Hayee, B.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Hermann, B.

Hitzenberger, C.

Hofer, B.

Hu, S.

Ikeda, H.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Inoue, H.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Izatt, J.

Izatt, J. A.

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

Jeong, S. Y.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Jiang, H.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, “Inverted multiscale optical resolution photoacoustic microscopy,” J. Biophotonics 10(12), 1580–1585 (2017).
[Crossref] [PubMed]

T. Jin, H. Guo, H. Jiang, B. Ke, and L. Xi, “Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging,” Opt. Lett. 42(21), 4434–4437 (2017).
[Crossref] [PubMed]

Jiao, S.

X. Zhang, H. F. Zhang, and S. Jiao, “Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source,” J. Biomed. Opt. 17(3), 030502 (2012).
[Crossref] [PubMed]

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

Z. Xie, S. Jiao, H. F. Zhang, and C. A. Puliafito, “Laser-scanning optical-resolution photoacoustic microscopy,” Opt. Lett. 34(12), 1771–1773 (2009).
[Crossref] [PubMed]

Jin, T.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, “Inverted multiscale optical resolution photoacoustic microscopy,” J. Biophotonics 10(12), 1580–1585 (2017).
[Crossref] [PubMed]

W. Qin, W. Qi, T. Jin, H. Guo, and L. Xi, “In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography,” Appl. Phys. Lett. 111(26), 263704 (2017).
[Crossref]

T. Jin, H. Guo, H. Jiang, B. Ke, and L. Xi, “Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging,” Opt. Lett. 42(21), 4434–4437 (2017).
[Crossref] [PubMed]

Kaga, M.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Kamiyama, I.

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

Karamata, B.

Katakura, A.

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

Ke, B.

Kim, C.

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

Kim, K.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Ko, T.

Kowalczyk, A.

Kuai, D.

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

Kwon, I. C.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

LaRocca, F.

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

Lasser, T.

Laufer, J.

Leary, J. J.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Lee, C. K.

Lee, H. C.

Lee, S. Y.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Li, L.

L. Li, B. Rao, K. Maslov, and L. V. Wang, “Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy,” Proc. SPIE 7564, 75641Z (2010).
[Crossref]

Liu, M.

Liu, N.

Liu, T.

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

Maslov, K.

S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett. 36(7), 1134–1136 (2011).
[Crossref] [PubMed]

L. Li, B. Rao, K. Maslov, and L. V. Wang, “Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy,” Proc. SPIE 7564, 75641Z (2010).
[Crossref]

Minami, H.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Nam, T.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Nankivil, D.

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

Nassif, N.

Nazaradeh, F.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Nomura, T.

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

O’Rourke, M. F.

M. F. O’Rourke and M. E. Safar, “Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy,” Hypertension 46(1), 200–204 (2005).
[Crossref] [PubMed]

Park, B. H.

Park, K.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Park, S.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Pedley, B.

Pehamberger, H.

Pierce, M. C.

Povazay, B.

Puliafito, C. A.

Qi, W.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, “Inverted multiscale optical resolution photoacoustic microscopy,” J. Biophotonics 10(12), 1580–1585 (2017).
[Crossref] [PubMed]

W. Qin, W. Qi, T. Jin, H. Guo, and L. Xi, “In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography,” Appl. Phys. Lett. 111(26), 263704 (2017).
[Crossref]

Qin, W.

W. Qin, W. Qi, T. Jin, H. Guo, and L. Xi, “In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography,” Appl. Phys. Lett. 111(26), 263704 (2017).
[Crossref]

Rao, B.

L. Li, B. Rao, K. Maslov, and L. V. Wang, “Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy,” Proc. SPIE 7564, 75641Z (2010).
[Crossref]

Rong, J.

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, “Inverted multiscale optical resolution photoacoustic microscopy,” J. Biophotonics 10(12), 1580–1585 (2017).
[Crossref] [PubMed]

Ruehm, S. G.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Safar, M. E.

M. F. O’Rourke and M. E. Safar, “Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy,” Hypertension 46(1), 200–204 (2005).
[Crossref] [PubMed]

Sakr, Y.

D. De Backer, J. Creteur, M. J. Dubois, Y. Sakr, and J. L. Vincent, “Microvascular alterations in patients with acute severe heart failure and cardiogenic shock,” Am. Heart J. 147(1), 91–99 (2004).
[Crossref] [PubMed]

Santi, E. G.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Sarunic, M.

Sato, C.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Sato, H.

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Shibahara, T.

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

Song, I. C.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Song, W.

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

Srinivasan, V.

Sticker, M.

Sun, D.

Takano, J. H.

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

Takano, N.

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

Tearney, G. J.

Toth, C. A.

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

Treeby, B.

Tsai, M. T.

Vincent, J. L.

D. De Backer, J. Creteur, M. J. Dubois, Y. Sakr, and J. L. Vincent, “Microvascular alterations in patients with acute severe heart failure and cardiogenic shock,” Am. Heart J. 147(1), 91–99 (2004).
[Crossref] [PubMed]

Vogt, F. M.

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Wang, L. V.

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

S. Hu, K. Maslov, and L. V. Wang, “Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed,” Opt. Lett. 36(7), 1134–1136 (2011).
[Crossref] [PubMed]

L. Li, B. Rao, K. Maslov, and L. V. Wang, “Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy,” Proc. SPIE 7564, 75641Z (2010).
[Crossref]

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

Wang, X.

Wang, Y. M.

Wei, Q.

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

Wei, X.

Weingast, J.

Wojtkowski, M.

Xi, L.

T. Jin, H. Guo, H. Jiang, B. Ke, and L. Xi, “Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging,” Opt. Lett. 42(21), 4434–4437 (2017).
[Crossref] [PubMed]

W. Qin, W. Qi, T. Jin, H. Guo, and L. Xi, “In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography,” Appl. Phys. Lett. 111(26), 263704 (2017).
[Crossref]

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, “Inverted multiscale optical resolution photoacoustic microscopy,” J. Biophotonics 10(12), 1580–1585 (2017).
[Crossref] [PubMed]

Xia, Y.

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

Xie, Z.

Xing, D.

Xing, W.

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

Xu, M.

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

Yakushiji, T.

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

Yang, C.

Yang, C. C.

Yang, S.

Yao, J.

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

Yu, C. H.

Yuk, S. A.

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Yun, S. H.

Zabihian, B.

Zawadzki, R.

Zhang, E.

Zhang, E. Z.

Zhang, H. F.

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

X. Zhang, H. F. Zhang, and S. Jiao, “Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source,” J. Biomed. Opt. 17(3), 030502 (2012).
[Crossref] [PubMed]

Z. Xie, S. Jiao, H. F. Zhang, and C. A. Puliafito, “Laser-scanning optical-resolution photoacoustic microscopy,” Opt. Lett. 34(12), 1771–1773 (2009).
[Crossref] [PubMed]

Zhang, X.

X. Zhang, H. F. Zhang, and S. Jiao, “Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source,” J. Biomed. Opt. 17(3), 030502 (2012).
[Crossref] [PubMed]

Zhang, Y. S.

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

Am. Heart J. (1)

D. De Backer, J. Creteur, M. J. Dubois, Y. Sakr, and J. L. Vincent, “Microvascular alterations in patients with acute severe heart failure and cardiogenic shock,” Am. Heart J. 147(1), 91–99 (2004).
[Crossref] [PubMed]

Angew. Chem. Int. Ed. Engl. (1)

Y. S. Zhang, X. Cai, J. Yao, W. Xing, L. V. Wang, and Y. Xia, “Non-Invasive and In Situ Characterization of the Degradation of Biomaterial Scaffolds by Volumetric Photoacoustic Microscopy,” Angew. Chem. Int. Ed. Engl. 53(1), 184–188 (2014).
[Crossref] [PubMed]

Ann. Gastroenterol. (1)

H. Inoue, M. Kaga, H. Ikeda, C. Sato, H. Sato, H. Minami, E. G. Santi, B. Hayee, and N. Eleftheriadis, “Magnification endoscopy in esophageal squamous cell carcinoma: a review of the intrapapillary capillary loop classification,” Ann. Gastroenterol. 28(1), 41–48 (2015).
[PubMed]

Appl. Phys. Lett. (1)

W. Qin, W. Qi, T. Jin, H. Guo, and L. Xi, “In vivo oral imaging with integrated portable photoacoustic microscopy and optical coherence tomography,” Appl. Phys. Lett. 111(26), 263704 (2017).
[Crossref]

Bioconjug. Chem. (1)

T. Nam, S. Park, S. Y. Lee, K. Park, K. Choi, I. C. Song, M. H. Han, J. J. Leary, S. A. Yuk, I. C. Kwon, K. Kim, and S. Y. Jeong, “Tumor targeting chitosan nanoparticles for dual-modality optical/mr cancer imaging,” Bioconjug. Chem. 21(4), 578–582 (2010).
[Crossref] [PubMed]

Biomed. Opt. Express (3)

Chem. Rev. (1)

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

Diabetes Metab. Res. Rev. (1)

C. Y. L. Chao and G. L. Y. Cheing, “Microvascular dysfunction in diabetic foot disease and ulceration,” Diabetes Metab. Res. Rev. 25(7), 604–614 (2009).
[Crossref] [PubMed]

Hypertension (1)

M. F. O’Rourke and M. E. Safar, “Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy,” Hypertension 46(1), 200–204 (2005).
[Crossref] [PubMed]

Int. J. Oral Maxillofac. Surg. (1)

J. H. Takano, T. Yakushiji, I. Kamiyama, T. Nomura, A. Katakura, N. Takano, and T. Shibahara, “Detecting early oral cancer: narrowband imaging system observation of the oral mucosa microvasculature,” Int. J. Oral Maxillofac. Surg. 39(3), 208–213 (2010).
[Crossref] [PubMed]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

J. Biomed. Opt. (2)

W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17(6), 061206 (2012).
[Crossref] [PubMed]

X. Zhang, H. F. Zhang, and S. Jiao, “Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source,” J. Biomed. Opt. 17(3), 030502 (2012).
[Crossref] [PubMed]

J. Biophotonics (1)

W. Qi, T. Jin, J. Rong, H. Jiang, and L. Xi, “Inverted multiscale optical resolution photoacoustic microscopy,” J. Biophotonics 10(12), 1580–1585 (2017).
[Crossref] [PubMed]

JAMA (1)

G. Antoch, F. M. Vogt, L. S. Freudenberg, F. Nazaradeh, S. C. Goehde, J. Barkhausen, G. Dahmen, A. Bockisch, J. F. Debatin, and S. G. Ruehm, “Whole-Body Dual-Modality PET/CT and Whole-Body MRI for Tumor Staging in Oncology,” JAMA 290(24), 3199–3206 (2003).
[Crossref] [PubMed]

Nat. Photonics (1)

F. LaRocca, D. Nankivil, T. DuBose, C. A. Toth, S. Farsiu, and J. A. Izatt, “In vivo cellular-resolution retinal imaging in infants and children using an ultracompact handheld probe,” Nat. Photonics 10(9), 580–584 (2016).
[Crossref] [PubMed]

Opt. Express (4)

Opt. Lett. (6)

Proc. SPIE (1)

L. Li, B. Rao, K. Maslov, and L. V. Wang, “Fast-scanning reflection-mode integrated photoacoustic and optical-coherence microscopy,” Proc. SPIE 7564, 75641Z (2010).
[Crossref]

Rev. Sci. Instrum. (1)

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77(4), 041101 (2006).
[Crossref]

Science (1)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

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Figures (5)

Fig. 1
Fig. 1 The schematic of the handheld ORPAM-OCT system and volumetric rendering of the imaging probe. (a) The schematic of the system configuration. O, Objective lens; FC, 2 × 2 fiber coupler; PC, fiber polarization controller; L, convex lens; M, reference mirror. (b) 3-D rendering of the handheld probe. CM, cold mirror; DL, doublet lens; CG, cover glass; UT, ultrasonic transducer. (c) Photograph of the handheld probe with a size of 65 mm × 30 mm × 18 mm. (d) The synchronization and trigger sequences for dual-modality imaging.
Fig. 2
Fig. 2 Spatial resolutions of the handheld microscope. (a) The raw data, fitted edge spread function (ESF) and derived line spread function (LSF) of the blade edge (ORPAM). (b) The raw data, fitted edge spread function (ESF) and derived line spread function (LSF) of the blade edge (OCT). (c) The raw data and fitted profile of a Hilbert-transformed A-line (ORPAM). (d) The fitted point spread function (PSF) of a mirror surface (OCT).
Fig. 3
Fig. 3 ORPAM and OCT imaging results of carbon fibers. (a) The maximum amplitude projection (MAP) ORPAM image of carbon fibers. (b) The 3-D rendering of carbon fibers imaged by OCT. (c) The selected ORPAM B-scan along the white dotted line in (a). (d) The selected OCT B-scan along the white dotted line in (b), SM, sealing membrane.
Fig. 4
Fig. 4 Dual modality imaging results of a mouse ear. (a) The maximum amplitude projection (MAP) image of the mouse ear (ORPAM). (b) The 3-D rendering of the mouse ear (OCT). (c) A typical ORPAM B-scan along the white dotted line in (a). (d) A typical OCT B-scan along the white dotted line in (b), E, epidermis; D, dermis; C, cartilage.
Fig. 5
Fig. 5 In vivo human oral imaging. (a) The MAP image of vasculatures in a human lower lip (ORPAM). (b) 3D image of oral mucosa in the same region of a human lower lip (OCT) with (a). (c) ORPAM and OCT B-scans along the white dotted line in (a) and (b), E, Epidermis; SG, salivary gland; LP, lamina propria. (d) The MAP image of vasculatures in a human upper lip (ORPAM). (e) 3D image of oral mucosa in the same human upper lip (OCT). (f) ORPAM and OCT B-scans along the white dotted line in (d) and (e). (g) The MAP image of vasculatures in bottom surface of a human tongue (ORPAM). (h) 3D rendering of the superficial structures of the same region in the human tongue (OCT). (i) ORPAM and OCT B-scans along the white dotted line in (g) and (h). Scale bar, 300μm.