Abstract

The diagnosis of acute kidney disease (AKI) has been examined mainly by histology, immunohistochemistry and western blot. Though these approaches are widely accepted in the field, it has an inherent limitation due to the lack of high-throughput and quantitative information. For a better understanding of prognosis in AKI, we present a new approach using quantitative phase imaging combined with a wide-field scanning platform. Through the phase-delay information from the tissue, we were able to predict a stage of AKI based on various optical properties such as light scattering coefficient and anisotropy. These optical parameters quantify the deterioration process of the AKI model of tissue. Our device would be a very useful tool when it is required to deliver fast feedback of tissue pathology or when diseases are related to mechanical properties such as fibrosis.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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2017 (4)

H. Majeed, C. Okoro, A. Kajdacsy-Balla, K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref] [PubMed]

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
[Crossref] [PubMed]

E. Min, S. Ban, Y. Wang, S. C. Bae, G. Popescu, C. Best-Popescu, and W. Jung, “Measurement of multispectral scattering properties in mouse brain tissue,” Biomed. Opt. Express 8(3), 1763–1770 (2017).
[Crossref] [PubMed]

2016 (3)

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

2015 (2)

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci Rep 5, 9976 (2015).

2014 (4)

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

P. Memmolo, L. Miccio, A. Finizio, P. A. Netti, and P. Ferraro, “Holographic tracking of living cells by three-dimensional reconstructed complex wavefronts alignment,” Opt. Lett. 39(9), 2759–2762 (2014).
[Crossref] [PubMed]

2013 (4)

2012 (4)

P. Memmolo, M. Iannone, M. Ventre, P. A. Netti, A. Finizio, M. Paturzo, and P. Ferraro, “On the holographic 3D tracking of in vitro cells characterized by a highly-morphological change,” Opt. Express 20(27), 28485–28493 (2012).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).

V. Bianco, M. Paturzo, A. Finizio, D. Balduzzi, R. Puglisi, A. Galli, and P. Ferraro, “Clear coherent imaging in turbid microfluidics by multiple holographic acquisitions,” Opt. Lett. 37(20), 4212–4214 (2012).
[Crossref] [PubMed]

2011 (6)

2010 (1)

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

2009 (1)

2008 (2)

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

2007 (1)

Y. Chen, P. M. Andrews, A. D. Aguirre, J. M. Schmitt, and J. G. Fujimoto, “High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo,” J. Biomed. Opt. 12(3), 034008 (2007).
[Crossref] [PubMed]

2006 (1)

2004 (2)

2002 (1)

P. Glover and P. Mansfield, “Limits to magnetic resonance microscospy,” Rep. Prog. Phys. 65, 1489 (2002).

1984 (1)

M. S. Paller, J. R. Hoidal, and T. F. Ferris, “Oxygen free radicals in ischemic acute renal failure in the rat,” J. Clin. Invest. 74(4), 1156–1164 (1984).
[Crossref] [PubMed]

Aguirre, A. D.

Y. Chen, P. M. Andrews, A. D. Aguirre, J. M. Schmitt, and J. G. Fujimoto, “High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo,” J. Biomed. Opt. 12(3), 034008 (2007).
[Crossref] [PubMed]

Andrews, P. M.

Q. Li, M. L. Onozato, P. M. Andrews, C. W. Chen, A. Paek, R. Naphas, S. Yuan, J. Jiang, A. Cable, and Y. Chen, “Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT),” Opt. Express 17(18), 16000–16016 (2009).
[Crossref] [PubMed]

Y. Chen, P. M. Andrews, A. D. Aguirre, J. M. Schmitt, and J. G. Fujimoto, “High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo,” J. Biomed. Opt. 12(3), 034008 (2007).
[Crossref] [PubMed]

Arbabi, A.

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).

Badizadegan, K.

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

G. Popescu, L. P. Deflores, J. C. Vaughan, K. Badizadegan, H. Iwai, R. R. Dasari, and M. S. Feld, “Fourier phase microscopy for investigation of biological structures and dynamics,” Opt. Lett. 29(21), 2503–2505 (2004).
[Crossref] [PubMed]

Bae, S. C.

Balduzzi, D.

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, A. Finizio, D. Balduzzi, R. Puglisi, A. Galli, and P. Ferraro, “Clear coherent imaging in turbid microfluidics by multiple holographic acquisitions,” Opt. Lett. 37(20), 4212–4214 (2012).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Balla, A.

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

Ban, S.

Bashir, R.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Basile, D. P.

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

Bednarz, M.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Bennett, N. C.

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Bently, M. D.

A. Garcia-Sanz, A. Rodriguez-Barbero, M. D. Bently, E. L. Ritman, and J. C. Romero, “Three-dimensional micro-copmuted tomography of renal vasculature in rats,” Hypertension31(440 (1998).

Best-Popescu, C.

E. Min, S. Ban, Y. Wang, S. C. Bae, G. Popescu, C. Best-Popescu, and W. Jung, “Measurement of multispectral scattering properties in mouse brain tissue,” Biomed. Opt. Express 8(3), 1763–1770 (2017).
[Crossref] [PubMed]

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Bhaduri, B.

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Bianco, V.

Brown, L.

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Cable, A.

Causa, F.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Chen, C. W.

Chen, Y.

Q. Li, M. L. Onozato, P. M. Andrews, C. W. Chen, A. Paek, R. Naphas, S. Yuan, J. Jiang, A. Cable, and Y. Chen, “Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT),” Opt. Express 17(18), 16000–16016 (2009).
[Crossref] [PubMed]

Y. Chen, P. M. Andrews, A. D. Aguirre, J. M. Schmitt, and J. G. Fujimoto, “High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo,” J. Biomed. Opt. 12(3), 034008 (2007).
[Crossref] [PubMed]

Choi, W.

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

Colditz, P.

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Collett, J. A.

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

Coppola, G.

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Crone, A.

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

Dale, B.

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

Dale, R.

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

Dannhauser, D.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Dasari, R. R.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

G. Popescu, L. P. Deflores, J. C. Vaughan, K. Badizadegan, H. Iwai, R. R. Dasari, and M. S. Feld, “Fourier phase microscopy for investigation of biological structures and dynamics,” Opt. Lett. 29(21), 2503–2505 (2004).
[Crossref] [PubMed]

Deflores, L.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Deflores, L. P.

Di Caprio, G.

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Di Matteo, L.

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

Ding, H.

Distante, C.

Edwards, C.

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

H. V. Pham, C. Edwards, L. L. Goddard, and G. Popescu, “Fast phase reconstruction in white light diffraction phase microscopy,” Appl. Opt. 52(1), A97–A101 (2013).
[Crossref] [PubMed]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).

Eremin, Y.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Esposito, G.

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

Feld, M. S.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

G. Popescu, L. P. Deflores, J. C. Vaughan, K. Badizadegan, H. Iwai, R. R. Dasari, and M. S. Feld, “Fourier phase microscopy for investigation of biological structures and dynamics,” Opt. Lett. 29(21), 2503–2505 (2004).
[Crossref] [PubMed]

Ferraro, P.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

P. Memmolo, L. Miccio, A. Finizio, P. A. Netti, and P. Ferraro, “Holographic tracking of living cells by three-dimensional reconstructed complex wavefronts alignment,” Opt. Lett. 39(9), 2759–2762 (2014).
[Crossref] [PubMed]

M. Matrecano, M. Paturzo, A. Finizio, and P. Ferraro, “Enhancing depth of focus in tilted microfluidics channels by digital holography,” Opt. Lett. 38(6), 896–898 (2013).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, O. Gennari, A. Finizio, and P. Ferraro, “Imaging through scattering microfluidic channels by digital holography for information recovery in lab on chip,” Opt. Express 21(20), 23985–23996 (2013).
[Crossref] [PubMed]

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, A. Finizio, D. Balduzzi, R. Puglisi, A. Galli, and P. Ferraro, “Clear coherent imaging in turbid microfluidics by multiple holographic acquisitions,” Opt. Lett. 37(20), 4212–4214 (2012).
[Crossref] [PubMed]

P. Memmolo, M. Iannone, M. Ventre, P. A. Netti, A. Finizio, M. Paturzo, and P. Ferraro, “On the holographic 3D tracking of in vitro cells characterized by a highly-morphological change,” Opt. Express 20(27), 28485–28493 (2012).
[Crossref] [PubMed]

F. Merola, L. Miccio, M. Paturzo, A. Finizio, S. Grilli, and P. Ferraro, “Driving and analysis of micro-objects by digital holographic microscope in microfluidics,” Opt. Lett. 36(16), 3079–3081 (2011).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

P. Memmolo, A. Finizio, M. Paturzo, L. Miccio, and P. Ferraro, “Twin-beams digital holography for 3D tracking and quantitative phase-contrast microscopy in microfluidics,” Opt. Express 19(25), 25833–25842 (2011).
[Crossref] [PubMed]

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Ferris, T. F.

M. S. Paller, J. R. Hoidal, and T. F. Ferris, “Oxygen free radicals in ischemic acute renal failure in the rat,” J. Clin. Invest. 74(4), 1156–1164 (1984).
[Crossref] [PubMed]

Finizio, A.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

P. Memmolo, L. Miccio, A. Finizio, P. A. Netti, and P. Ferraro, “Holographic tracking of living cells by three-dimensional reconstructed complex wavefronts alignment,” Opt. Lett. 39(9), 2759–2762 (2014).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, O. Gennari, A. Finizio, and P. Ferraro, “Imaging through scattering microfluidic channels by digital holography for information recovery in lab on chip,” Opt. Express 21(20), 23985–23996 (2013).
[Crossref] [PubMed]

M. Matrecano, M. Paturzo, A. Finizio, and P. Ferraro, “Enhancing depth of focus in tilted microfluidics channels by digital holography,” Opt. Lett. 38(6), 896–898 (2013).
[Crossref] [PubMed]

P. Memmolo, M. Iannone, M. Ventre, P. A. Netti, A. Finizio, M. Paturzo, and P. Ferraro, “On the holographic 3D tracking of in vitro cells characterized by a highly-morphological change,” Opt. Express 20(27), 28485–28493 (2012).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, A. Finizio, D. Balduzzi, R. Puglisi, A. Galli, and P. Ferraro, “Clear coherent imaging in turbid microfluidics by multiple holographic acquisitions,” Opt. Lett. 37(20), 4212–4214 (2012).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

P. Memmolo, A. Finizio, M. Paturzo, L. Miccio, and P. Ferraro, “Twin-beams digital holography for 3D tracking and quantitative phase-contrast microscopy in microfluidics,” Opt. Express 19(25), 25833–25842 (2011).
[Crossref] [PubMed]

F. Merola, L. Miccio, M. Paturzo, A. Finizio, S. Grilli, and P. Ferraro, “Driving and analysis of micro-objects by digital holographic microscope in microfluidics,” Opt. Lett. 36(16), 3079–3081 (2011).
[Crossref] [PubMed]

Fujimoto, J. G.

Y. Chen, P. M. Andrews, A. D. Aguirre, J. M. Schmitt, and J. G. Fujimoto, “High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo,” J. Biomed. Opt. 12(3), 034008 (2007).
[Crossref] [PubMed]

Galli, A.

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, A. Finizio, D. Balduzzi, R. Puglisi, A. Galli, and P. Ferraro, “Clear coherent imaging in turbid microfluidics by multiple holographic acquisitions,” Opt. Lett. 37(20), 4212–4214 (2012).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Garcia-Sanz, A.

A. Garcia-Sanz, A. Rodriguez-Barbero, M. D. Bently, E. L. Ritman, and J. C. Romero, “Three-dimensional micro-copmuted tomography of renal vasculature in rats,” Hypertension31(440 (1998).

Gennari, O.

Gioffre, M. A.

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Glover, P.

P. Glover and P. Mansfield, “Limits to magnetic resonance microscospy,” Rep. Prog. Phys. 65, 1489 (2002).

Gobe, G. C.

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Goddard, L. L.

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

H. V. Pham, C. Edwards, L. L. Goddard, and G. Popescu, “Fast phase reconstruction in white light diffraction phase microscopy,” Appl. Opt. 52(1), A97–A101 (2013).
[Crossref] [PubMed]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).

Golding, I.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Grilli, S.

F. Merola, L. Miccio, M. Paturzo, A. Finizio, S. Grilli, and P. Ferraro, “Driving and analysis of micro-objects by digital holographic microscope in microfluidics,” Opt. Lett. 36(16), 3079–3081 (2011).
[Crossref] [PubMed]

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Hellmers, J.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Hoidal, J. R.

M. S. Paller, J. R. Hoidal, and T. F. Ferris, “Oxygen free radicals in ischemic acute renal failure in the rat,” J. Clin. Invest. 74(4), 1156–1164 (1984).
[Crossref] [PubMed]

Iannone, M.

Ikeda, T.

Iwai, H.

Jeong, Y.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Jiang, J.

Johnson, D. W.

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Jung, J.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Jung, W.

E. Min, S. Ban, Y. Wang, S. C. Bae, G. Popescu, C. Best-Popescu, and W. Jung, “Measurement of multispectral scattering properties in mouse brain tissue,” Biomed. Opt. Express 8(3), 1763–1770 (2017).
[Crossref] [PubMed]

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

Kajdacsy-Balla, A.

H. Majeed, C. Okoro, A. Kajdacsy-Balla, K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref] [PubMed]

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci Rep 5, 9976 (2015).

Kandel, M. E.

M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
[Crossref] [PubMed]

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

Kim, K.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Ko, C. J.

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

Lee, E.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Lee, M.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Lee, S.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Li, Q.

Lue, N.

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Macias, V.

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci Rep 5, 9976 (2015).

Majeed, H.

H. Majeed, C. Okoro, A. Kajdacsy-Balla, K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref] [PubMed]

Mansfield, P.

P. Glover and P. Mansfield, “Limits to magnetic resonance microscospy,” Rep. Prog. Phys. 65, 1489 (2002).

March, K. L.

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

Matrecano, M.

Mehrotra, P.

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

Memmolo, P.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

P. Memmolo, L. Miccio, A. Finizio, P. A. Netti, and P. Ferraro, “Holographic tracking of living cells by three-dimensional reconstructed complex wavefronts alignment,” Opt. Lett. 39(9), 2759–2762 (2014).
[Crossref] [PubMed]

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

P. Memmolo, M. Iannone, M. Ventre, P. A. Netti, A. Finizio, M. Paturzo, and P. Ferraro, “On the holographic 3D tracking of in vitro cells characterized by a highly-morphological change,” Opt. Express 20(27), 28485–28493 (2012).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

P. Memmolo, A. Finizio, M. Paturzo, L. Miccio, and P. Ferraro, “Twin-beams digital holography for 3D tracking and quantitative phase-contrast microscopy in microfluidics,” Opt. Express 19(25), 25833–25842 (2011).
[Crossref] [PubMed]

Merfeld-Clauss, S.

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

Merola, F.

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

F. Merola, L. Miccio, M. Paturzo, A. Finizio, S. Grilli, and P. Ferraro, “Driving and analysis of micro-objects by digital holographic microscope in microfluidics,” Opt. Lett. 36(16), 3079–3081 (2011).
[Crossref] [PubMed]

Miccio, L.

Min, E.

E. Min, S. Ban, Y. Wang, S. C. Bae, G. Popescu, C. Best-Popescu, and W. Jung, “Measurement of multispectral scattering properties in mouse brain tissue,” Biomed. Opt. Express 8(3), 1763–1770 (2017).
[Crossref] [PubMed]

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

Mir, M.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Mitra, A.

R. W. Schrier, W. Wang, B. Poole, and A. Mitra, “Acute renal failure: definitions, diagnosis, pathogenesis, and therapy,” J. Clin. Invest. 114(1), 5–14 (2004).
[Crossref] [PubMed]

Miura, T.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Naphas, R.

Netti, P.

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

Netti, P. A.

Nguyen, T. H.

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Nishinaka, T.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Okoro, C.

H. Majeed, C. Okoro, A. Kajdacsy-Balla, K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref] [PubMed]

Onozato, M. L.

Paek, A.

Paller, M. S.

M. S. Paller, J. R. Hoidal, and T. F. Ferris, “Oxygen free radicals in ischemic acute renal failure in the rat,” J. Clin. Invest. 74(4), 1156–1164 (1984).
[Crossref] [PubMed]

Park, Y.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Paturzo, M.

M. Matrecano, M. Paturzo, A. Finizio, and P. Ferraro, “Enhancing depth of focus in tilted microfluidics channels by digital holography,” Opt. Lett. 38(6), 896–898 (2013).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, O. Gennari, A. Finizio, and P. Ferraro, “Imaging through scattering microfluidic channels by digital holography for information recovery in lab on chip,” Opt. Express 21(20), 23985–23996 (2013).
[Crossref] [PubMed]

P. Memmolo, M. Iannone, M. Ventre, P. A. Netti, A. Finizio, M. Paturzo, and P. Ferraro, “On the holographic 3D tracking of in vitro cells characterized by a highly-morphological change,” Opt. Express 20(27), 28485–28493 (2012).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, A. Finizio, D. Balduzzi, R. Puglisi, A. Galli, and P. Ferraro, “Clear coherent imaging in turbid microfluidics by multiple holographic acquisitions,” Opt. Lett. 37(20), 4212–4214 (2012).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

P. Memmolo, A. Finizio, M. Paturzo, L. Miccio, and P. Ferraro, “Twin-beams digital holography for 3D tracking and quantitative phase-contrast microscopy in microfluidics,” Opt. Express 19(25), 25833–25842 (2011).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

F. Merola, L. Miccio, M. Paturzo, A. Finizio, S. Grilli, and P. Ferraro, “Driving and analysis of micro-objects by digital holographic microscope in microfluidics,” Opt. Lett. 36(16), 3079–3081 (2011).
[Crossref] [PubMed]

Pham, H.

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Pham, H. V.

Poole, B.

R. W. Schrier, W. Wang, B. Poole, and A. Mitra, “Acute renal failure: definitions, diagnosis, pathogenesis, and therapy,” J. Clin. Invest. 114(1), 5–14 (2004).
[Crossref] [PubMed]

Popescu, G.

H. Majeed, C. Okoro, A. Kajdacsy-Balla, K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref] [PubMed]

M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
[Crossref] [PubMed]

E. Min, S. Ban, Y. Wang, S. C. Bae, G. Popescu, C. Best-Popescu, and W. Jung, “Measurement of multispectral scattering properties in mouse brain tissue,” Biomed. Opt. Express 8(3), 1763–1770 (2017).
[Crossref] [PubMed]

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci Rep 5, 9976 (2015).

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

H. V. Pham, C. Edwards, L. L. Goddard, and G. Popescu, “Fast phase reconstruction in white light diffraction phase microscopy,” Appl. Opt. 52(1), A97–A101 (2013).
[Crossref] [PubMed]

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

Z. Wang, H. Ding, and G. Popescu, “Scattering-phase theorem,” Opt. Lett. 36(7), 1215–1217 (2011).
[Crossref] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

G. Popescu, L. P. Deflores, J. C. Vaughan, K. Badizadegan, H. Iwai, R. R. Dasari, and M. S. Feld, “Fourier phase microscopy for investigation of biological structures and dynamics,” Opt. Lett. 29(21), 2503–2505 (2004).
[Crossref] [PubMed]

Prasanth, S. G.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Puglisi, R.

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, A. Finizio, D. Balduzzi, R. Puglisi, A. Galli, and P. Ferraro, “Clear coherent imaging in turbid microfluidics by multiple holographic acquisitions,” Opt. Lett. 37(20), 4212–4214 (2012).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Ritman, E. L.

A. Garcia-Sanz, A. Rodriguez-Barbero, M. D. Bently, E. L. Ritman, and J. C. Romero, “Three-dimensional micro-copmuted tomography of renal vasculature in rats,” Hypertension31(440 (1998).

Rodriguez-Barbero, A.

A. Garcia-Sanz, A. Rodriguez-Barbero, M. D. Bently, E. L. Ritman, and J. C. Romero, “Three-dimensional micro-copmuted tomography of renal vasculature in rats,” Hypertension31(440 (1998).

Romero, J. C.

A. Garcia-Sanz, A. Rodriguez-Barbero, M. D. Bently, E. L. Ritman, and J. C. Romero, “Three-dimensional micro-copmuted tomography of renal vasculature in rats,” Hypertension31(440 (1998).

Rossi, D.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Saffioti, N.

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

Schmitt, J. M.

Y. Chen, P. M. Andrews, A. D. Aguirre, J. M. Schmitt, and J. G. Fujimoto, “High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo,” J. Biomed. Opt. 12(3), 034008 (2007).
[Crossref] [PubMed]

Schrier, R. W.

R. W. Schrier, W. Wang, B. Poole, and A. Mitra, “Acute renal failure: definitions, diagnosis, pathogenesis, and therapy,” J. Clin. Invest. 114(1), 5–14 (2004).
[Crossref] [PubMed]

Shan, M.

Shen, Z.

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Shimokawa, T.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Sridharan, S.

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci Rep 5, 9976 (2015).

Takama, M.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Tanba, T.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Tangella, K.

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci Rep 5, 9976 (2015).

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

Terada, T.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Tojo, A.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Toussaint, K. C.

H. Majeed, C. Okoro, A. Kajdacsy-Balla, K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref] [PubMed]

Traktuev, D. O.

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

Tsutsui, H.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Vaughan, J. C.

Ventre, M.

Vesey, D. A.

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Wang, W.

R. W. Schrier, W. Wang, B. Poole, and A. Mitra, “Acute renal failure: definitions, diagnosis, pathogenesis, and therapy,” J. Clin. Invest. 114(1), 5–14 (2004).
[Crossref] [PubMed]

Wang, Y.

Wang, Z.

Z. Wang, H. Ding, and G. Popescu, “Scattering-phase theorem,” Opt. Lett. 36(7), 1215–1217 (2011).
[Crossref] [PubMed]

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

West, M.

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Wilding, M.

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

Wriedt, T.

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

Yamagata, M.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Yoon, J.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Yoshida, S.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Yu, H.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Yuan, S.

Yukimura, T.

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

Zhou, R. J.

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Adv. Opt. Photonics (1)

B. Bhaduri, C. Edwards, H. Pham, R. J. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Am. J. Physiol. Cell Physiol. (1)

G. Popescu, Y. Park, N. Lue, C. Best-Popescu, L. Deflores, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Optical imaging of cell mass and growth dynamics,” Am. J. Physiol. Cell Physiol. 295(2), C538–C544 (2008).
[Crossref] [PubMed]

Am. J. Physiol. Renal Physiol. (1)

G. C. Gobe, N. C. Bennett, M. West, P. Colditz, L. Brown, D. A. Vesey, and D. W. Johnson, “Increased progression to kidney fibrosis after erythropoietin is used as a treatment for acute kidney injury,” Am. J. Physiol. Renal Physiol. 306(6), F681–F692 (2014).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (1)

Blood Cells Mol. Dis. (1)

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

Eur J Pharmacol (1)

T. Shimokawa, H. Tsutsui, T. Miura, T. Nishinaka, T. Terada, M. Takama, S. Yoshida, T. Tanba, A. Tojo, M. Yamagata, and T. Yukimura, “Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through alpha2C-adrenoceptors in rats,” Eur J Pharmacol 781, 36–44 (2016).

IEEE J. Sel. Top. Quantum Electron. (1)

G. Di Caprio, M. A. Gioffre, N. Saffioti, S. Grilli, P. Ferraro, R. Puglisi, D. Balduzzi, A. Galli, and G. Coppola, “Quantitative Label-Free Animal Sperm Imaging by Means of Digital Holographic Microscopy,” IEEE J. Sel. Top. Quantum Electron. 16(4), 833–840 (2010).
[Crossref]

J. Biomed. Opt. (3)

Y. Chen, P. M. Andrews, A. D. Aguirre, J. M. Schmitt, and J. G. Fujimoto, “High-resolution three-dimensional optical coherence tomography imaging of kidney microanatomy ex vivo,” J. Biomed. Opt. 12(3), 034008 (2007).
[Crossref] [PubMed]

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

H. Majeed, C. Okoro, A. Kajdacsy-Balla, K. C. Toussaint, and G. Popescu, “Quantifying collagen fiber orientation in breast cancer using quantitative phase imaging,” J. Biomed. Opt. 22(4), 046004 (2017).
[Crossref] [PubMed]

J. Cell. Mol. Med. (1)

J. A. Collett, D. O. Traktuev, P. Mehrotra, A. Crone, S. Merfeld-Clauss, K. L. March, and D. P. Basile, “Human adipose stromal cell therapy improves survival and reduces renal inflammation and capillary rarefaction in acute kidney injury,” J. Cell. Mol. Med. 21(7), 1420–1430 (2017).
[Crossref] [PubMed]

J. Clin. Invest. (2)

M. S. Paller, J. R. Hoidal, and T. F. Ferris, “Oxygen free radicals in ischemic acute renal failure in the rat,” J. Clin. Invest. 74(4), 1156–1164 (1984).
[Crossref] [PubMed]

R. W. Schrier, W. Wang, B. Poole, and A. Mitra, “Acute renal failure: definitions, diagnosis, pathogenesis, and therapy,” J. Clin. Invest. 114(1), 5–14 (2004).
[Crossref] [PubMed]

Lab Chip (3)

M. Paturzo, A. Finizio, P. Memmolo, R. Puglisi, D. Balduzzi, A. Galli, and P. Ferraro, “Microscopy imaging and quantitative phase contrast mapping in turbid microfluidic channels by digital holography,” Lab Chip 12(17), 3073–3076 (2012).
[Crossref] [PubMed]

D. Dannhauser, D. Rossi, F. Causa, P. Memmolo, A. Finizio, T. Wriedt, J. Hellmers, Y. Eremin, P. Ferraro, and P. A. Netti, “Optical signature of erythrocytes by light scattering in microfluidic flows,” Lab Chip 15(16), 3278–3285 (2015).
[Crossref] [PubMed]

F. Merola, L. Miccio, P. Memmolo, G. Di Caprio, A. Galli, R. Puglisi, D. Balduzzi, G. Coppola, P. Netti, and P. Ferraro, “Digital holography as a method for 3D imaging and estimating the biovolume of motile cells,” Lab Chip 13(23), 4512–4516 (2013).
[Crossref] [PubMed]

Light Sci. Appl. (1)

C. Edwards, A. Arbabi, G. Popescu, and L. L. Goddard, “Optically monitoring and controlling nanoscale topography during semiconductor etching,” Light Sci. Appl. 1, e30 (2012).

Opt. Express (6)

P. Memmolo, M. Iannone, M. Ventre, P. A. Netti, A. Finizio, M. Paturzo, and P. Ferraro, “On the holographic 3D tracking of in vitro cells characterized by a highly-morphological change,” Opt. Express 20(27), 28485–28493 (2012).
[Crossref] [PubMed]

V. Bianco, M. Paturzo, O. Gennari, A. Finizio, and P. Ferraro, “Imaging through scattering microfluidic channels by digital holography for information recovery in lab on chip,” Opt. Express 21(20), 23985–23996 (2013).
[Crossref] [PubMed]

Q. Li, M. L. Onozato, P. M. Andrews, C. W. Chen, A. Paek, R. Naphas, S. Yuan, J. Jiang, A. Cable, and Y. Chen, “Automated quantification of microstructural dimensions of the human kidney using optical coherence tomography (OCT),” Opt. Express 17(18), 16000–16016 (2009).
[Crossref] [PubMed]

P. Memmolo, G. Di Caprio, C. Distante, M. Paturzo, R. Puglisi, D. Balduzzi, A. Galli, G. Coppola, and P. Ferraro, “Identification of bovine sperm head for morphometry analysis in quantitative phase-contrast holographic microscopy,” Opt. Express 19(23), 23215–23226 (2011).
[Crossref] [PubMed]

P. Memmolo, A. Finizio, M. Paturzo, L. Miccio, and P. Ferraro, “Twin-beams digital holography for 3D tracking and quantitative phase-contrast microscopy in microfluidics,” Opt. Express 19(25), 25833–25842 (2011).
[Crossref] [PubMed]

M. Shan, M. E. Kandel, and G. Popescu, “Refractive index variance of cells and tissues measured by quantitative phase imaging,” Opt. Express 25(2), 1573–1581 (2017).
[Crossref] [PubMed]

Opt. Lett. (7)

Proc. Natl. Acad. Sci. U.S.A. (1)

M. Mir, Z. Wang, Z. Shen, M. Bednarz, R. Bashir, I. Golding, S. G. Prasanth, and G. Popescu, “Optical measurement of cycle-dependent cell growth,” Proc. Natl. Acad. Sci. U.S.A. 108(32), 13124–13129 (2011).
[Crossref] [PubMed]

Rep. Prog. Phys. (1)

P. Glover and P. Mansfield, “Limits to magnetic resonance microscospy,” Rep. Prog. Phys. 65, 1489 (2002).

Sci Rep (3)

S. Sridharan, V. Macias, K. Tangella, A. Kajdacsy-Balla, and G. Popescu, “Prediction of prostate cancer recurrence using quantitative phase imaging,” Sci Rep 5, 9976 (2015).

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci Rep 6, 39667 (2016).

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer's disease,” Sci Rep 6, 31034 (2016).

Zygote (1)

G. Coppola, G. Di Caprio, M. Wilding, P. Ferraro, G. Esposito, L. Di Matteo, R. Dale, G. Coppola, and B. Dale, “Digital holographic microscopy for the evaluation of human sperm structure,” Zygote 22(4), 446–454 (2014).
[Crossref] [PubMed]

Other (1)

A. Garcia-Sanz, A. Rodriguez-Barbero, M. D. Bently, E. L. Ritman, and J. C. Romero, “Three-dimensional micro-copmuted tomography of renal vasculature in rats,” Hypertension31(440 (1998).

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Figures (6)

Fig. 1
Fig. 1 Experimental set-up and phase delay image reconstruction. (a) Schematic of the DPM optical set up using with long-range XY scanning stages and detailed optical path. (b) Measured raw interferogram. (c) Spatial frequency domain spectrum of (b). The first order (rectangular box) is shifted to the origin, an operation that is based on Hilbert transform. (d) Retrieved QPI of kidney tissue imaged in (b). (e) Corresponding H&E stained tissue.
Fig. 2
Fig. 2 H&E and DPM imaging of a mouse kidney tissue in coronal way. Entire wide-field imaging of the kidney tissue slice is presented on the left (A) and right column (a) for H&E and DPM, respectively. Major regions was denoted with different color shade in (a). Black boxes in the H&E stained images denote specific anatomical components in various layers. The same regions denoted by white boxes in the DPM images. These insets include: renal cortex (C/c), outer medulla (D/d), boundary between inner medulla and pelvis (E/e). Glomerular Capsule, renal capillaries, proximal convoluted tubule, and distal convoluted tubule in the cortex are presented in C1/c1, C2/c2, C3/c3, and C4/c4, respectively. Medullary components of the thick loop of Henle, thin loop of Henle, and collecting tubule are shown in D1/d1, D2/d2 and D3/d3, respectively. A group of collecting duct has been delineated in E1/e1.
Fig. 3
Fig. 3 (a) Phase delay of kidney cortex region after 0, 3, 5 and 7 day of AKI. (b) Glomerular phase delay in cortex after 0, 3, 5 and 7 day of AKI. Inset of each stage in (a) and (b) represents one of the randomly selected phase map. Box plot is made by average of each map. The box covers the 25–75% percentiles representing the standard deviation of averaged phase maps, and the maximum length of whisker is 2 times the standard deviation. (c) The size ratio of capillary to a single glomerular capsule. Glomerular capillaries are segmented out of bowman’s space as shown in inset of (c). (d) Linear fit between phase delay in cortex and glomerular phase delay (red), same study between glomerular size ratio and glomerular phase delay (blue).
Fig. 4
Fig. 4 Optical parameter maps associated with the kidney tissue slice obtained from the quantitative phase image. Phase delay image of kidney coronal slice for AKI model in time scale (first column). Remapped with g (second column) and µs (third column) for the same kidney sample.
Fig. 5
Fig. 5 AKI prognosis through optical properties. The us and g retrieved based on scattering-phase theorem, as described in text. (a) Plot of quantitatively calculated µs of renal cortex in time scale of AKI. (b) Plot of quantitative g in same time scale of AKI. The µs and g both are plotted using box plot. The box covers the 25–75% percentiles representing standard deviation, and the maximum length of whisker is 2 times the standard deviation. (c) Linear fit between geometrical information of glomerular capillary size and g in cortex region (red), and between size of glomerular capillaries and µs (green). (d) Density contour plot of optical properties of AKI mode.
Fig. 6
Fig. 6 Area fraction in capillary is closely associated with renal fibrosis in I/R-induced progressive kidney fibrosis. (a) Immunohistochemistry of DAPI in wide field, and magnified cortex region of DAPI, α-SMA, and collagen I in time scale of AKI. (b) Time course of quantified positively stained area fractions for α-SMA and (c) collagen I. (d) Significant correlations were found between the computationally filled α-SMA area fraction and scattering coefficient in renal cortex (red), and also found between collagen I and scattering coefficient in renal cortex (green). (d) Another significant correlations were found between the computationally filled α-SMA area fraction and anisotropy in renal cortex (red), and also found between collagen I and anisotropy in renal cortex (green).

Equations (2)

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μ s = Δ ϕ 2 ( r ) r L
g=1 1 2 k ο 2 | [ ϕ( r ) ] | 2 r Δ ϕ 2 ( r ) 2 r

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