Abstract

In adaptive optics scanning laser ophthalmoscope (AOSLO) systems, capturing multiply scattered light can increase the contrast of the retinal microvasculature structure, cone inner segments, and retinal ganglion cells. Current systems generally use either a split detector or offset aperture approach to collect this light. We tested the ability of a spatial light modulator (SLM) as a rapidly configurable aperture to use more complex shapes to enhance the contrast of retinal structure. Particularly, we varied the orientation of a split detector aperture and explored the use of a more complex shape, the half annulus, to enhance the contrast of the retinal vasculature. We used the new approach to investigate the influence of scattering distance and orientation on vascular imaging.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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  1. R. H. Webb, G. W. Hughes, and F. C. Delori, “Confocal scanning laser ophthalmoscope,” Appl. Opt. 26(8), 1492–1499 (1987).
    [Crossref] [PubMed]
  2. A. Elsner, M. Miura, S. Burns, E. Beausencourt, C. Kunze, L. Kelley, J. Walker, G. Wing, P. Raskauskas, D. Fletcher, Q. Zhou, and A. Dreher, “Multiply scattered light tomography and confocal imaging: detecting neovascularization in age-related macular degeneration,” Opt. Express 7(2), 95–106 (2000).
    [Crossref] [PubMed]
  3. A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, “Infrared imaging of sub-retinal structures in the human ocular fundus,” Vision Res. 36(1), 191–205 (1996).
    [Crossref] [PubMed]
  4. T. Y. Chui, D. A. Vannasdale, and S. A. Burns, “The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope,” Biomed. Opt. Express 3(10), 2537–2549 (2012).
    [Crossref] [PubMed]
  5. D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
    [Crossref] [PubMed]
  6. S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, “Improved contrast of subretinal structures using polarization analysis,” Invest. Ophthalmol. Vis. Sci. 44(9), 4061–4068 (2003).
    [Crossref] [PubMed]
  7. S. A. Burns, A. E. Elsner, T. Y. Chui, D. A. Vannasdale, C. A. Clark, T. J. Gast, V. E. Malinovsky, and A. D. Phan, “In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy,” Biomed. Opt. Express 5(3), 961–974 (2014).
    [Crossref] [PubMed]
  8. J. G. Hillard, T. J. Gast, T. Y. Chui, D. Sapir, and S. A. Burns, “Retinal Arterioles in Hypo-, Normo-, and Hypertensive Subjects Measured Using Adaptive Optics,” Transl. Vis. Sci. Technol. 5(4), 16 (2016).
    [Crossref] [PubMed]
  9. T. Y. Chui, T. J. Gast, and S. A. Burns, “Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 54(10), 7115–7124 (2013).
    [Crossref] [PubMed]
  10. T. Y. Chui, M. Dubow, A. Pinhas, N. Shah, A. Gan, R. Weitz, Y. N. Sulai, A. Dubra, and R. B. Rosen, “Comparison of adaptive optics scanning light ophthalmoscopic fluorescein angiography and offset pinhole imaging,” Biomed. Opt. Express 5(4), 1173–1189 (2014).
    [Crossref] [PubMed]
  11. A. de Castro, G. Huang, L. Sawides, T. Luo, and S. A. Burns, “Rapid high resolution imaging with a dual-channel scanning technique,” Opt. Lett. 41(8), 1881–1884 (2016).
    [Crossref] [PubMed]
  12. Y. N. Sulai, D. Scoles, Z. Harvey, and A. Dubra, “Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope,” J. Opt. Soc. Am. A 31(3), 569–579 (2014).
    [Crossref] [PubMed]
  13. L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
    [Crossref] [PubMed]
  14. B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
    [Crossref] [PubMed]
  15. M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
    [Crossref] [PubMed]
  16. C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
    [Crossref] [PubMed]
  17. C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
    [Crossref] [PubMed]
  18. K. M. Litts, R. F. Cooper, J. L. Duncan, and J. Carroll, “Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging,” Invest. Ophthalmol. Vis. Sci. 58(6), BIO255 (2017).
    [Crossref] [PubMed]
  19. E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
    [Crossref] [PubMed]
  20. S. A. Burns, R. Tumbar, A. E. Elsner, D. Ferguson, and D. X. Hammer, “Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope,” J. Opt. Soc. Am. A 24(5), 1313–1326 (2007).
    [Crossref] [PubMed]
  21. R. D. Ferguson, Z. Zhong, D. X. Hammer, M. Mujat, A. H. Patel, C. Deng, W. Zou, and S. A. Burns, “Adaptive optics scanning laser ophthalmoscope with integrated wide-field retinal imaging and tracking,” J. Opt. Soc. Am. A 27(11), A265–A277 (2010).
    [Crossref] [PubMed]
  22. W. Zou, X. Qi, and S. A. Burns, “Woofer-tweeter adaptive optics scanning laser ophthalmoscopic imaging based on Lagrange-multiplier damped least-squares algorithm,” Biomed. Opt. Express 2(7), 1986–2004 (2011).
    [Crossref] [PubMed]
  23. W. Zou, X. Qi, and S. A. Burns, “Wavefront-aberration sorting and correction for a dual-deformable-mirror adaptive-optics system,” Opt. Lett. 33(22), 2602–2604 (2008).
    [Crossref] [PubMed]
  24. T. Luo, T. J. Gast, T. J. Vermeer, and S. A. Burns, “Retinal Vascular Branching in Healthy and Diabetic Subjects,” Invest. Ophthalmol. Vis. Sci. 58(5), 2685–2694 (2017).
    [Crossref] [PubMed]
  25. G. Huang, Z. Zhong, W. Zou, and S. A. Burns, “Lucky averaging: quality improvement of adaptive optics scanning laser ophthalmoscope images,” Opt. Lett. 36(19), 3786–3788 (2011).
    [Crossref] [PubMed]
  26. K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
    [Crossref] [PubMed]

2017 (6)

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

K. M. Litts, R. F. Cooper, J. L. Duncan, and J. Carroll, “Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging,” Invest. Ophthalmol. Vis. Sci. 58(6), BIO255 (2017).
[Crossref] [PubMed]

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

T. Luo, T. J. Gast, T. J. Vermeer, and S. A. Burns, “Retinal Vascular Branching in Healthy and Diabetic Subjects,” Invest. Ophthalmol. Vis. Sci. 58(5), 2685–2694 (2017).
[Crossref] [PubMed]

K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
[Crossref] [PubMed]

2016 (5)

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

A. de Castro, G. Huang, L. Sawides, T. Luo, and S. A. Burns, “Rapid high resolution imaging with a dual-channel scanning technique,” Opt. Lett. 41(8), 1881–1884 (2016).
[Crossref] [PubMed]

J. G. Hillard, T. J. Gast, T. Y. Chui, D. Sapir, and S. A. Burns, “Retinal Arterioles in Hypo-, Normo-, and Hypertensive Subjects Measured Using Adaptive Optics,” Transl. Vis. Sci. Technol. 5(4), 16 (2016).
[Crossref] [PubMed]

2014 (4)

2013 (1)

T. Y. Chui, T. J. Gast, and S. A. Burns, “Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 54(10), 7115–7124 (2013).
[Crossref] [PubMed]

2012 (1)

2011 (2)

2010 (1)

2008 (1)

2007 (1)

2003 (1)

S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, “Improved contrast of subretinal structures using polarization analysis,” Invest. Ophthalmol. Vis. Sci. 44(9), 4061–4068 (2003).
[Crossref] [PubMed]

2000 (1)

1996 (1)

A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, “Infrared imaging of sub-retinal structures in the human ocular fundus,” Vision Res. 36(1), 191–205 (1996).
[Crossref] [PubMed]

1987 (1)

Abozaid, M. A.

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

Beausencourt, E.

Burns, S.

Burns, S. A.

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

T. Luo, T. J. Gast, T. J. Vermeer, and S. A. Burns, “Retinal Vascular Branching in Healthy and Diabetic Subjects,” Invest. Ophthalmol. Vis. Sci. 58(5), 2685–2694 (2017).
[Crossref] [PubMed]

J. G. Hillard, T. J. Gast, T. Y. Chui, D. Sapir, and S. A. Burns, “Retinal Arterioles in Hypo-, Normo-, and Hypertensive Subjects Measured Using Adaptive Optics,” Transl. Vis. Sci. Technol. 5(4), 16 (2016).
[Crossref] [PubMed]

A. de Castro, G. Huang, L. Sawides, T. Luo, and S. A. Burns, “Rapid high resolution imaging with a dual-channel scanning technique,” Opt. Lett. 41(8), 1881–1884 (2016).
[Crossref] [PubMed]

S. A. Burns, A. E. Elsner, T. Y. Chui, D. A. Vannasdale, C. A. Clark, T. J. Gast, V. E. Malinovsky, and A. D. Phan, “In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy,” Biomed. Opt. Express 5(3), 961–974 (2014).
[Crossref] [PubMed]

T. Y. Chui, T. J. Gast, and S. A. Burns, “Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 54(10), 7115–7124 (2013).
[Crossref] [PubMed]

T. Y. Chui, D. A. Vannasdale, and S. A. Burns, “The use of forward scatter to improve retinal vascular imaging with an adaptive optics scanning laser ophthalmoscope,” Biomed. Opt. Express 3(10), 2537–2549 (2012).
[Crossref] [PubMed]

W. Zou, X. Qi, and S. A. Burns, “Woofer-tweeter adaptive optics scanning laser ophthalmoscopic imaging based on Lagrange-multiplier damped least-squares algorithm,” Biomed. Opt. Express 2(7), 1986–2004 (2011).
[Crossref] [PubMed]

G. Huang, Z. Zhong, W. Zou, and S. A. Burns, “Lucky averaging: quality improvement of adaptive optics scanning laser ophthalmoscope images,” Opt. Lett. 36(19), 3786–3788 (2011).
[Crossref] [PubMed]

R. D. Ferguson, Z. Zhong, D. X. Hammer, M. Mujat, A. H. Patel, C. Deng, W. Zou, and S. A. Burns, “Adaptive optics scanning laser ophthalmoscope with integrated wide-field retinal imaging and tracking,” J. Opt. Soc. Am. A 27(11), A265–A277 (2010).
[Crossref] [PubMed]

W. Zou, X. Qi, and S. A. Burns, “Wavefront-aberration sorting and correction for a dual-deformable-mirror adaptive-optics system,” Opt. Lett. 33(22), 2602–2604 (2008).
[Crossref] [PubMed]

S. A. Burns, R. Tumbar, A. E. Elsner, D. Ferguson, and D. X. Hammer, “Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope,” J. Opt. Soc. Am. A 24(5), 1313–1326 (2007).
[Crossref] [PubMed]

S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, “Improved contrast of subretinal structures using polarization analysis,” Invest. Ophthalmol. Vis. Sci. 44(9), 4061–4068 (2003).
[Crossref] [PubMed]

A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, “Infrared imaging of sub-retinal structures in the human ocular fundus,” Vision Res. 36(1), 191–205 (1996).
[Crossref] [PubMed]

Carroll, J.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

K. M. Litts, R. F. Cooper, J. L. Duncan, and J. Carroll, “Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging,” Invest. Ophthalmol. Vis. Sci. 58(6), BIO255 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
[Crossref] [PubMed]

Chiang, J.

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Chui, T. Y.

Chulay, J. D.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Chung, M. M.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Clark, C. A.

Collison, F. T.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Cooper, R. F.

K. M. Litts, R. F. Cooper, J. L. Duncan, and J. Carroll, “Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging,” Invest. Ophthalmol. Vis. Sci. 58(6), BIO255 (2017).
[Crossref] [PubMed]

Curcio, C. A.

D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
[Crossref] [PubMed]

de Castro, A.

Delori, F. C.

A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, “Infrared imaging of sub-retinal structures in the human ocular fundus,” Vision Res. 36(1), 191–205 (1996).
[Crossref] [PubMed]

R. H. Webb, G. W. Hughes, and F. C. Delori, “Confocal scanning laser ophthalmoscope,” Appl. Opt. 26(8), 1492–1499 (1987).
[Crossref] [PubMed]

Deng, C.

Dreher, A.

Dubis, A. M.

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

Dubow, M.

Dubra, A.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

T. Y. Chui, M. Dubow, A. Pinhas, N. Shah, A. Gan, R. Weitz, Y. N. Sulai, A. Dubra, and R. B. Rosen, “Comparison of adaptive optics scanning light ophthalmoscopic fluorescein angiography and offset pinhole imaging,” Biomed. Opt. Express 5(4), 1173–1189 (2014).
[Crossref] [PubMed]

Y. N. Sulai, D. Scoles, Z. Harvey, and A. Dubra, “Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope,” J. Opt. Soc. Am. A 31(3), 569–579 (2014).
[Crossref] [PubMed]

D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
[Crossref] [PubMed]

Duncan, J. L.

K. M. Litts, R. F. Cooper, J. L. Duncan, and J. Carroll, “Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging,” Invest. Ophthalmol. Vis. Sci. 58(6), BIO255 (2017).
[Crossref] [PubMed]

Elsner, A.

Elsner, A. E.

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

S. A. Burns, A. E. Elsner, T. Y. Chui, D. A. Vannasdale, C. A. Clark, T. J. Gast, V. E. Malinovsky, and A. D. Phan, “In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy,” Biomed. Opt. Express 5(3), 961–974 (2014).
[Crossref] [PubMed]

S. A. Burns, R. Tumbar, A. E. Elsner, D. Ferguson, and D. X. Hammer, “Large-field-of-view, modular, stabilized, adaptive-optics-based scanning laser ophthalmoscope,” J. Opt. Soc. Am. A 24(5), 1313–1326 (2007).
[Crossref] [PubMed]

S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, “Improved contrast of subretinal structures using polarization analysis,” Invest. Ophthalmol. Vis. Sci. 44(9), 4061–4068 (2003).
[Crossref] [PubMed]

A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, “Infrared imaging of sub-retinal structures in the human ocular fundus,” Vision Res. 36(1), 191–205 (1996).
[Crossref] [PubMed]

Erker, L. R.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Ferguson, D.

Ferguson, R. D.

Fischer, W.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Fishman, G. A.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
[Crossref] [PubMed]

Fletcher, D.

Gan, A.

Gast, T. J.

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

T. Luo, T. J. Gast, T. J. Vermeer, and S. A. Burns, “Retinal Vascular Branching in Healthy and Diabetic Subjects,” Invest. Ophthalmol. Vis. Sci. 58(5), 2685–2694 (2017).
[Crossref] [PubMed]

J. G. Hillard, T. J. Gast, T. Y. Chui, D. Sapir, and S. A. Burns, “Retinal Arterioles in Hypo-, Normo-, and Hypertensive Subjects Measured Using Adaptive Optics,” Transl. Vis. Sci. Technol. 5(4), 16 (2016).
[Crossref] [PubMed]

S. A. Burns, A. E. Elsner, T. Y. Chui, D. A. Vannasdale, C. A. Clark, T. J. Gast, V. E. Malinovsky, and A. D. Phan, “In vivo adaptive optics microvascular imaging in diabetic patients without clinically severe diabetic retinopathy,” Biomed. Opt. Express 5(3), 961–974 (2014).
[Crossref] [PubMed]

T. Y. Chui, T. J. Gast, and S. A. Burns, “Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 54(10), 7115–7124 (2013).
[Crossref] [PubMed]

Granger, C. E.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Hammer, D. X.

Harvey, Z.

Hauswirth, W. W.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Higgins, B. P.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Hillard, J. G.

J. G. Hillard, T. J. Gast, T. Y. Chui, D. Sapir, and S. A. Burns, “Retinal Arterioles in Hypo-, Normo-, and Hypertensive Subjects Measured Using Adaptive Optics,” Transl. Vis. Sci. Technol. 5(4), 16 (2016).
[Crossref] [PubMed]

Huang, G.

Hueck, K.

K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
[Crossref] [PubMed]

Hughes, G. W.

Hunter, J. J.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Johnson, R. D.

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

Kawakami, T.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Kay, C. N.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Kelley, L.

King, B. J.

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

Kunze, C.

Lam, B. L.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Langlo, C. S.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
[Crossref] [PubMed]

Latchney, L. R.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Litts, K. M.

K. M. Litts, R. F. Cooper, J. L. Duncan, and J. Carroll, “Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging,” Invest. Ophthalmol. Vis. Sci. 58(6), BIO255 (2017).
[Crossref] [PubMed]

Lompe, T.

K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
[Crossref] [PubMed]

Luick, N.

K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
[Crossref] [PubMed]

Luo, T.

T. Luo, T. J. Gast, T. J. Vermeer, and S. A. Burns, “Retinal Vascular Branching in Healthy and Diabetic Subjects,” Invest. Ophthalmol. Vis. Sci. 58(5), 2685–2694 (2017).
[Crossref] [PubMed]

A. de Castro, G. Huang, L. Sawides, T. Luo, and S. A. Burns, “Rapid high resolution imaging with a dual-channel scanning technique,” Opt. Lett. 41(8), 1881–1884 (2016).
[Crossref] [PubMed]

Malinovsky, V. E.

Mazurenko, A.

K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
[Crossref] [PubMed]

Mellem-Kairala, M. B.

S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, “Improved contrast of subretinal structures using polarization analysis,” Invest. Ophthalmol. Vis. Sci. 44(9), 4061–4068 (2003).
[Crossref] [PubMed]

Michaelides, M.

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

Miura, M.

Moritz, H.

K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
[Crossref] [PubMed]

Mujat, M.

Nozato, K.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Papay, J. A.

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

Parker, M.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Patel, A. H.

Patterson, E. J.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Pennesi, M. E.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Phan, A. D.

Pinhas, A.

Qi, X.

Raskauskas, P.

Razeen, M. M.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Rosen, R. B.

Rossi, E. A.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Saito, K.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Sapir, D.

J. G. Hillard, T. J. Gast, T. Y. Chui, D. Sapir, and S. A. Burns, “Retinal Arterioles in Hypo-, Normo-, and Hypertensive Subjects Measured Using Adaptive Optics,” Transl. Vis. Sci. Technol. 5(4), 16 (2016).
[Crossref] [PubMed]

Sapoznik, K. A.

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

Sawides, L.

Schwarz, C.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Scoles, D.

Y. N. Sulai, D. Scoles, Z. Harvey, and A. Dubra, “Visualization of retinal vascular structure and perfusion with a nonconfocal adaptive optics scanning light ophthalmoscope,” J. Opt. Soc. Am. A 31(3), 569–579 (2014).
[Crossref] [PubMed]

D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
[Crossref] [PubMed]

Shah, N.

Sharma, R.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Simmons, R. B.

S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, “Improved contrast of subretinal structures using polarization analysis,” Invest. Ophthalmol. Vis. Sci. 44(9), 4061–4068 (2003).
[Crossref] [PubMed]

Stepien, K. E.

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

Sulai, Y. N.

Summerfelt, P.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Sun, L. W.

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

Tarima, S.

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

Tumbar, R.

Vannasdale, D. A.

Vermeer, T. J.

T. Luo, T. J. Gast, T. J. Vermeer, and S. A. Burns, “Retinal Vascular Branching in Healthy and Diabetic Subjects,” Invest. Ophthalmol. Vis. Sci. 58(5), 2685–2694 (2017).
[Crossref] [PubMed]

Walker, J.

Walters, S.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Webb, R. H.

Weinberg, D. V.

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

Weiter, J. J.

A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, “Infrared imaging of sub-retinal structures in the human ocular fundus,” Vision Res. 36(1), 191–205 (1996).
[Crossref] [PubMed]

Weitz, R.

Weleber, R. G.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Williams, D. R.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Williams, V.

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

Wilson, D. J.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Wing, G.

Yang, P.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Yang, Q.

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Zhang, J.

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

Zhong, Z.

Zhou, Q.

Zou, W.

Adv. Exp. Med. Biol. (1)

M. A. Abozaid, C. S. Langlo, A. M. Dubis, M. Michaelides, S. Tarima, and J. Carroll, “Reliability and Repeatability of Cone Density Measurements in Patients with Congenital Achromatopsia,” Adv. Exp. Med. Biol. 854, 277–283 (2016).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (4)

Invest. Ophthalmol. Vis. Sci. (6)

D. Scoles, Y. N. Sulai, C. S. Langlo, G. A. Fishman, C. A. Curcio, J. Carroll, and A. Dubra, “In vivo imaging of human cone photoreceptor inner segments,” Invest. Ophthalmol. Vis. Sci. 55(7), 4244–4251 (2014).
[Crossref] [PubMed]

S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, “Improved contrast of subretinal structures using polarization analysis,” Invest. Ophthalmol. Vis. Sci. 44(9), 4061–4068 (2003).
[Crossref] [PubMed]

T. Y. Chui, T. J. Gast, and S. A. Burns, “Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy,” Invest. Ophthalmol. Vis. Sci. 54(10), 7115–7124 (2013).
[Crossref] [PubMed]

C. S. Langlo, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, L. R. Erker, M. Parker, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, D. J. Wilson, M. E. Pennesi, B. L. Lam, J. Chiang, J. D. Chulay, A. Dubra, W. W. Hauswirth, J. Carroll, and ACHM-001 Study Group, “Residual Foveal Cone Structure in CNGB3-Associated Achromatopsia,” Invest. Ophthalmol. Vis. Sci. 57(10), 3984–3995 (2016).
[Crossref] [PubMed]

K. M. Litts, R. F. Cooper, J. L. Duncan, and J. Carroll, “Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging,” Invest. Ophthalmol. Vis. Sci. 58(6), BIO255 (2017).
[Crossref] [PubMed]

T. Luo, T. J. Gast, T. J. Vermeer, and S. A. Burns, “Retinal Vascular Branching in Healthy and Diabetic Subjects,” Invest. Ophthalmol. Vis. Sci. 58(5), 2685–2694 (2017).
[Crossref] [PubMed]

J. Opt. Soc. Am. A (3)

Opt. Express (1)

Opt. Lett. (3)

Optom. Vis. Sci. (1)

B. J. King, K. A. Sapoznik, A. E. Elsner, T. J. Gast, J. A. Papay, C. A. Clark, and S. A. Burns, “SD-OCT and Adaptive Optics Imaging of Outer Retinal Tubulation,” Optom. Vis. Sci. 94(3), 411–422 (2017).
[Crossref] [PubMed]

PLoS One (1)

L. W. Sun, R. D. Johnson, V. Williams, P. Summerfelt, A. Dubra, D. V. Weinberg, K. E. Stepien, G. A. Fishman, and J. Carroll, “Multimodal Imaging of Photoreceptor Structure in Choroideremia,” PLoS One 11(12), e0167526 (2016).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

E. A. Rossi, C. E. Granger, R. Sharma, Q. Yang, K. Saito, C. Schwarz, S. Walters, K. Nozato, J. Zhang, T. Kawakami, W. Fischer, L. R. Latchney, J. J. Hunter, M. M. Chung, and D. R. Williams, “Imaging individual neurons in the retinal ganglion cell layer of the living eye,” Proc. Natl. Acad. Sci. U.S.A. 114(3), 586–591 (2017).
[Crossref] [PubMed]

Retina (1)

C. S. Langlo, L. R. Erker, M. Parker, E. J. Patterson, B. P. Higgins, P. Summerfelt, M. M. Razeen, F. T. Collison, G. A. Fishman, C. N. Kay, J. Zhang, R. G. Weleber, P. Yang, M. E. Pennesi, B. L. Lam, J. D. Chulay, A. Dubra, W. W. Hauswirth, D. J. Wilson, J. Carroll, and ACHM-001 study group, “Repeatability and Longitudinal Assessment of Foveal Cone Structure in Cngb3-Associated Achromatopsia,” Retina 37(10), 1956–1966 (2017).
[Crossref] [PubMed]

Rev. Sci. Instrum. (1)

K. Hueck, A. Mazurenko, N. Luick, T. Lompe, and H. Moritz, “Note: Suppression of kHz-frequency switching noise in digital micro-mirror devices,” Rev. Sci. Instrum. 88(1), 016103 (2017).
[Crossref] [PubMed]

Transl. Vis. Sci. Technol. (1)

J. G. Hillard, T. J. Gast, T. Y. Chui, D. Sapir, and S. A. Burns, “Retinal Arterioles in Hypo-, Normo-, and Hypertensive Subjects Measured Using Adaptive Optics,” Transl. Vis. Sci. Technol. 5(4), 16 (2016).
[Crossref] [PubMed]

Vision Res. (1)

A. E. Elsner, S. A. Burns, J. J. Weiter, and F. C. Delori, “Infrared imaging of sub-retinal structures in the human ocular fundus,” Vision Res. 36(1), 191–205 (1996).
[Crossref] [PubMed]

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Figures (5)

Fig. 1
Fig. 1 Zemax schematic of channel 1 detection. Light from the retina passes through a confocal pinhole at the first retinal conjugate plane (R1’) to produce a confocal image. The PSF surround is reflected from the pinhole surface and re-imaged to a second retinal conjugate plane (R2’). A series of lenses (L2-L3) are utilized to maintain a 1:1 magnification ratio at the SLM after the reflected light passes through a turning mirror (M1). At R2’ light is reflected to either the ON or OFF detector by an SLM (micromirror array) acting as a programmable aperture. A. Example of a split detector configuration on the array (ON = white, OFF = black). B. Example of a half annulus configuration on the array.
Fig. 2
Fig. 2 Simultaneously acquired images of a venule and arteriole in a normal 34 year old male. Venule images (A-E). Arteriole images (F-J). A and F. Confocal images from the first channel (2 ADD centered aperture). B and G. Offset aperture images (10 ADD displaced aperture) from the second channel. C, D, and E. ON, OFF and ratio multiply scattered light images of the venule obtained with a split annulus orientated at 270° with an inner radius of 5.3 ADD and outer radius of 22.7 ADD. H, I and J. ON, OFF and ratio multiply scattered light images obtained with a half annulus oriented at 45° and with an inner radius of 8.3 ADD (H) and an outer radius of 22.7 ADD. Excellent wall contrast of both the arteriole (H and J) and venule (C and E) is generated with the split annulus apertures. The insets depict the aperture configuration at the center of the SLM with the red asterisk indicating the portion of the array generating the image. Scale bar = 50μm.
Fig. 3
Fig. 3 Arteriole ratio images with different apertures. Small arteriole in a healthy 34 year old (A-D). Large arteriole in a hypertensive 31 year old (E-H). Mural cell contrast in the small arteriole is higher with a smaller inner radius (A, 3.8 ADD vs. B, 11.3 ADD) but not for the larger arteriole (E and F) for a fixed outer radius of 22.7 ADD. Orthogonal split detector orientation of a small (C and D) and large (G and H) arteriole. When the split detector is roughly orthogonal to the cell walls (C and H), the contrast of the mural cells is higher, whereas, when the split is roughly parallel to the wall itself, the contrast of the wall border is higher (D and G). Contrast of the small vessel branch (C and D, blue arrowheads) is highly dependent on the orientation of the split detector. Scale bar = 50µm.
Fig. 4
Fig. 4 Wall contrast depends on distance from the center of the PSF with a half annulus oriented roughly parallel to the vessel. Contrast was measured between the vessel wall and surrounding retina by integrating intensity values parallel to the vessel and averaging along roughly 70 μm (red box). As the inner radius increased from 10 ADD (A) to 25 ADD (D) in 5 ADD increments, contrast decreased from 21.3% (A), 13.5% (B), 10.6% (C), to 2.4% (D). The outer radius was maintained at 10 ADD larger than the inner radius. Scale bar = 100 μm.
Fig. 5
Fig. 5 Retinal feature contrast varies with half annulus orientation at a fixed inner and outer radius (8.3 ADD and 22.7 ADD) in a healthy 24 yo subject. Arteriole wall contrast of the parent vessel changed with the half annulus angle orientation (compare A and I vs C and G). An array of presumed ganglion cells are visible at all orientations and follow the orientation of the nerve fiber layer. The confocal image (E) is shown for comparison. Scale bar = 100 μm.

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