Abstract

In this pilot study, we have evaluated bedside diffuse optical monitoring combining diffuse correlation spectroscopy and near-infrared diffuse optical spectroscopy to assess the effect of thrombolysis with an intravenous recombinant tissue plasminogen activator (rtPA) on cerebral hemodynamics in an acute ischemic stroke. Frontal lobes of five patients with an acute middle cerebral artery occlusion were measured bilaterally during rtPA treatment. Both ipsilesional and contralesional hemispheres showed significant increases in cerebral blood flow, total hemoglobin concentration and oxy-hemoglobin concentration during the first 2.5 hours after rtPA bolus. The increases were faster and higher in the ipsilesional hemisphere. The results show that bedside optical monitoring can detect the effect of reperfusion therapy for ischemic stroke in real-time.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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Corrections

22 February 2018: A typographical correction was made to the author listing.


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References

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2015 (4)

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

T. Ritzenthaler, T. H. Cho, D. Luis, Y. Berthezene, and N. Nighoghossian, “Usefulness of near-infrared spectroscopy in thrombectomy monitoring,” J. Clin. Monit. Comput. 29, 585–589 (2015).
[Crossref]

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
[Crossref] [PubMed]

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

2014 (7)

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, J. Martí-Fàbregas, and T. Durduran, “Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion,” Acad. Radiol. 21, 168–174 (2014).
[Crossref] [PubMed]

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85, 51–63 (2014).
[Crossref]

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

2012 (1)

M. Ferrari and V. Quaresima, “A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application,” Neuroimage 63, 921–935 (2012).

2011 (1)

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

2010 (3)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73, 76701 (2010).
[Crossref]

M. J. H. Aries, J. W. Elting, J. De Keyser, B. P. H. Kremer, and P. C. A. J. Vroomen, “Cerebral autoregulation in stroke: A review of transcranial doppler studies,” Stroke 41, 2697–2704 (2010).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1, 1443–1459 (2010).
[Crossref]

2009 (3)

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

B. P. Soares, J. D. Chien, and M. Wintermark, “MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!” Stroke 40, 24–28 (2009).
[Crossref]

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

2007 (2)

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

D. Comelli, A. Bassi, A. Pifferi, P. Taroni, A. Torricelli, R. Cubeddu, F. Martelli, and G. Zaccanti, “In vivo time-resolved reflectance spectroscopy of the human forehead,” Appl. Opt. 46, 1717–1725 (2007).
[Crossref] [PubMed]

2005 (1)

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

2004 (2)

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[Crossref] [PubMed]

2002 (1)

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

2001 (1)

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[Crossref] [PubMed]

2000 (2)

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

1998 (1)

H. Nagashima, H. Okudera, S. Kobayashi, and T. Iwashita, “Monitoring of cerebral hemodynamics using near-infrared spectroscopy during local intraarterial thrombolysis: case report,” Surg. Neurol. 49, 420–424 (1998).
[Crossref] [PubMed]

1996 (1)

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

1995 (2)

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75, 1855 (1995).
[Crossref] [PubMed]

G. Seidel, M. Kaps, and T. Gerriets, “Potential and limitations of transcranial color-coded sonography in stroke patients,” Stroke 26, 2061–2066 (1995).
[Crossref] [PubMed]

1986 (1)

F. Kirkham, T. Padayachee, S. Parsons, L. Seargeant, F. House, and R. Gosling, “Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow,” Ultrasound Med Biol. 12, 15–21 (1986).
[Crossref] [PubMed]

Abramson, K.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

Alexandrov, A.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Alexandrov, A. V.

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

Alvarez-Sabín, J.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Aries, M. J. H.

M. J. H. Aries, J. W. Elting, J. De Keyser, B. P. H. Kremer, and P. C. A. J. Vroomen, “Cerebral autoregulation in stroke: A review of transcranial doppler studies,” Stroke 41, 2697–2704 (2010).
[Crossref] [PubMed]

Arjun, G.

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

Armon, C.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Babikian, V.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Baker, W. B.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73, 76701 (2010).
[Crossref]

Barber, P. A.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Baron, J. C.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Bassi, A.

Bates, D. M.

J. C. Pinheiro and D. M. Bates, Mixed-effects models in S and S-PLUS (2000).
[Crossref]

Berthezene, Y.

T. Ritzenthaler, T. H. Cho, D. Luis, Y. Berthezene, and N. Nighoghossian, “Usefulness of near-infrared spectroscopy in thrombectomy monitoring,” J. Clin. Monit. Comput. 29, 585–589 (2015).
[Crossref]

Berthezène, Y.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Bladin, C.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Boas, D. A.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75, 1855 (1995).
[Crossref] [PubMed]

Bösel, J.

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
[Crossref] [PubMed]

Buckley, E. M.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

Burgin, W. S.

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

Burnett, M. G.

Busch, D. R.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

Butcher, K.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Caffini, M.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

Campbell, L. E.

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75, 1855 (1995).
[Crossref] [PubMed]

Caplan, L.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Carp, S. A.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

Carrera, D.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

Chan, S.-T.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

Cheung, C.

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[Crossref] [PubMed]

Chien, J. D.

B. P. Soares, J. D. Chien, and M. Wintermark, “MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!” Stroke 40, 24–28 (2009).
[Crossref]

Cho, T. H.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

T. Ritzenthaler, T. H. Cho, D. Luis, Y. Berthezene, and N. Nighoghossian, “Usefulness of near-infrared spectroscopy in thrombectomy monitoring,” J. Clin. Monit. Comput. 29, 585–589 (2015).
[Crossref]

Choe, R.

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73, 76701 (2010).
[Crossref]

Christensen, S.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Christou, I.

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

Clemence, M.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Comelli, D.

Contini, D.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

Cope, M.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Cubeddu, R.

Culver, J. P.

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[Crossref] [PubMed]

Davis, S. M.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

De Keyser, J.

M. J. H. Aries, J. W. Elting, J. De Keyser, B. P. H. Kremer, and P. C. A. J. Vroomen, “Cerebral autoregulation in stroke: A review of transcranial doppler studies,” Stroke 41, 2697–2704 (2010).
[Crossref] [PubMed]

De Silva, D. A.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Delgado, P.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Delgado-Mederos, R.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, J. Martí-Fàbregas, and T. Durduran, “Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion,” Acad. Radiol. 21, 168–174 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1, 1443–1459 (2010).
[Crossref]

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Delpy, D. T.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Demchuk, A. M.

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

Derex, L.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Detre, J. A.

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[Crossref] [PubMed]

Dinia, L.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, J. Martí-Fàbregas, and T. Durduran, “Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion,” Acad. Radiol. 21, 168–174 (2014).
[Crossref] [PubMed]

Donnan, G. A.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Duncan, A.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Durduran, T.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, J. Martí-Fàbregas, and T. Durduran, “Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion,” Acad. Radiol. 21, 168–174 (2014).
[Crossref] [PubMed]

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85, 51–63 (2014).
[Crossref]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73, 76701 (2010).
[Crossref]

P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1, 1443–1459 (2010).
[Crossref]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[Crossref] [PubMed]

Ebinger, M.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Edlow, B. L.

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

Elting, J. W.

M. J. H. Aries, J. W. Elting, J. De Keyser, B. P. H. Kremer, and P. C. A. J. Vroomen, “Cerebral autoregulation in stroke: A review of transcranial doppler studies,” Stroke 41, 2697–2704 (2010).
[Crossref] [PubMed]

Elwell, C. E.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Evans, K. C.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

Fallon, P.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Favilla, C. G.

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

Felberg, A.

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

Felberg, R. A.

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

Feldmann, E.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Ferrari, M.

M. Ferrari and V. Quaresima, “A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application,” Neuroimage 63, 921–935 (2012).

Fiehler, J.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Fink, J. N.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Frangos, S.

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

Gerriets, T.

G. Seidel, M. Kaps, and T. Gerriets, “Potential and limitations of transcranial color-coded sonography in stroke patients,” Stroke 26, 2061–2066 (1995).
[Crossref] [PubMed]

Goldman, R.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Gomez, C.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Goodin, D.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Gosling, R.

F. Kirkham, T. Padayachee, S. Parsons, L. Seargeant, F. House, and R. Gosling, “Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow,” Ultrasound Med Biol. 12, 15–21 (1986).
[Crossref] [PubMed]

Greenberg, J. H.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[Crossref] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[Crossref] [PubMed]

Gröschel, K.

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

Grotta, J. C.

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

Hametner, C.

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
[Crossref] [PubMed]

Hermier, M.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Hoshi, Y.

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

House, F.

F. Kirkham, T. Padayachee, S. Parsons, L. Seargeant, F. House, and R. Gosling, “Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow,” Ultrasound Med Biol. 12, 15–21 (1986).
[Crossref] [PubMed]

Hsu, C.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Iwashita, T.

H. Nagashima, H. Okudera, S. Kobayashi, and T. Iwashita, “Monitoring of cerebral hemodynamics using near-infrared spectroscopy during local intraarterial thrombolysis: case report,” Surg. Neurol. 49, 420–424 (1998).
[Crossref] [PubMed]

Kaps, M.

G. Seidel, M. Kaps, and T. Gerriets, “Potential and limitations of transcranial color-coded sonography in stroke patients,” Stroke 26, 2061–2066 (1995).
[Crossref] [PubMed]

Kasner, S. E.

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

Kastrup, A.

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

Kato, C.

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

Kim, M. N.

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

Kirkham, F.

F. Kirkham, T. Padayachee, S. Parsons, L. Seargeant, F. House, and R. Gosling, “Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow,” Ultrasound Med Biol. 12, 15–21 (1986).
[Crossref] [PubMed]

Ko, T. S.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

Kobayashi, S.

H. Nagashima, H. Okudera, S. Kobayashi, and T. Iwashita, “Monitoring of cerebral hemodynamics using near-infrared spectroscopy during local intraarterial thrombolysis: case report,” Surg. Neurol. 49, 420–424 (1998).
[Crossref] [PubMed]

Kohri, S.

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

Kremer, B. P. H.

M. J. H. Aries, J. W. Elting, J. De Keyser, B. P. H. Kremer, and P. C. A. J. Vroomen, “Cerebral autoregulation in stroke: A review of transcranial doppler studies,” Stroke 41, 2697–2704 (2010).
[Crossref] [PubMed]

Kuge, Y.

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

Kung, D. K.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

Lefkowitz, D.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Levi, C. R.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Levine, J. M.

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

Liebert, A.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Lu, X.

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

Luis, D.

T. Ritzenthaler, T. H. Cho, D. Luis, Y. Berthezene, and N. Nighoghossian, “Usefulness of near-infrared spectroscopy in thrombectomy monitoring,” J. Clin. Monit. Comput. 29, 585–589 (2015).
[Crossref]

Macdonald, R.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Maisterra, O.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Malkoff, M.

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
[Crossref] [PubMed]

W. S. Burgin, M. Malkoff, R. A. Felberg, A. M. Demchuk, I. Christou, J. C. Grotta, and A. V. Alexandrov, “Transcranial doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke,” Stroke. 31, 1128–1132 (2000).
[Crossref] [PubMed]

Martelli, F.

Martí-Fàbregas, J.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, J. Martí-Fàbregas, and T. Durduran, “Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion,” Acad. Radiol. 21, 168–174 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1, 1443–1459 (2010).
[Crossref]

Meek, J. H.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Mesquita, R. C.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

Mikkelsen, I. K.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Minkoff, D. L.

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

Molina, C. A.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Möller, M.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Montaner, J.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Mullen, M.

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

Munuera, J.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Nagashima, H.

H. Nagashima, H. Okudera, S. Kobayashi, and T. Iwashita, “Monitoring of cerebral hemodynamics using near-infrared spectroscopy during local intraarterial thrombolysis: case report,” Surg. Neurol. 49, 420–424 (1998).
[Crossref] [PubMed]

Newell, D.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Nighoghossian, N.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

T. Ritzenthaler, T. H. Cho, D. Luis, Y. Berthezene, and N. Nighoghossian, “Usefulness of near-infrared spectroscopy in thrombectomy monitoring,” J. Clin. Monit. Comput. 29, 585–589 (2015).
[Crossref]

Obrig, H.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Okudera, H.

H. Nagashima, H. Okudera, S. Kobayashi, and T. Iwashita, “Monitoring of cerebral hemodynamics using near-infrared spectroscopy during local intraarterial thrombolysis: case report,” Surg. Neurol. 49, 420–424 (1998).
[Crossref] [PubMed]

Østergaard, L.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Padayachee, T.

F. Kirkham, T. Padayachee, S. Parsons, L. Seargeant, F. House, and R. Gosling, “Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow,” Ultrasound Med Biol. 12, 15–21 (1986).
[Crossref] [PubMed]

Parsons, M.

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

Parsons, S.

F. Kirkham, T. Padayachee, S. Parsons, L. Seargeant, F. House, and R. Gosling, “Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow,” Ultrasound Med Biol. 12, 15–21 (1986).
[Crossref] [PubMed]

Parthasarathy, A. B.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

Pedraza, S.

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

Petrovitch, A.

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

Pifferi, A.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

D. Comelli, A. Bassi, A. Pifferi, P. Taroni, A. Torricelli, R. Cubeddu, F. Martelli, and G. Zaccanti, “In vivo time-resolved reflectance spectroscopy of the human forehead,” Appl. Opt. 46, 1717–1725 (2007).
[Crossref] [PubMed]

Pinheiro, J. C.

J. C. Pinheiro and D. M. Bates, Mixed-effects models in S and S-PLUS (2000).
[Crossref]

Quaresima, V.

M. Ferrari and V. Quaresima, “A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application,” Neuroimage 63, 921–935 (2012).

Re, R.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

Ribó, M.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Ringer, T.

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

Rinneberg, H.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Ritzenthaler, T.

T. Ritzenthaler, T. H. Cho, D. Luis, Y. Berthezene, and N. Nighoghossian, “Usefulness of near-infrared spectroscopy in thrombectomy monitoring,” J. Clin. Monit. Comput. 29, 585–589 (2015).
[Crossref]

Rohde, S.

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
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R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
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Rubiera, M.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
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Santamarina, E.

R. Delgado-Mederos, A. Rovira, J. Alvarez-Sabín, M. Ribó, J. Munuera, M. Rubiera, E. Santamarina, O. Maisterra, P. Delgado, J. Montaner, and C. A. Molina, “Speed of tPA-induced clot lysis predicts DWI lesion evolution in acute stroke,” Stroke 38, 955–960 (2007).
[Crossref] [PubMed]

Schnaudigel, S.

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

Seargeant, L.

F. Kirkham, T. Padayachee, S. Parsons, L. Seargeant, F. House, and R. Gosling, “Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: velocity as an index of flow,” Ultrasound Med Biol. 12, 15–21 (1986).
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G. Seidel, M. Kaps, and T. Gerriets, “Potential and limitations of transcranial color-coded sonography in stroke patients,” Stroke 26, 2061–2066 (1995).
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Selb, J.

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

Sloan, M.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Soares, B. P.

B. P. Soares, J. D. Chien, and M. Wintermark, “MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!” Stroke 40, 24–28 (2009).
[Crossref]

Spencer, M.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Spinelli, L.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

Stampfl, S.

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
[Crossref] [PubMed]

Stanarcevic, P.

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
[Crossref] [PubMed]

Steinbrink, J.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Sunar, U.

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

Takahashi, K.

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[Crossref] [PubMed]

Tamaki, N.

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

Tamura, M.

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

Taroni, P.

Tegeler, C.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Terborg, C.

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

Torricelli, A.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

D. Comelli, A. Bassi, A. Pifferi, P. Taroni, A. Torricelli, R. Cubeddu, F. Martelli, and G. Zaccanti, “In vivo time-resolved reflectance spectroscopy of the human forehead,” Appl. Opt. 46, 1717–1725 (2007).
[Crossref] [PubMed]

Tyszczuk, L.

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Tzeng, S.-Y.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

Veltkamp, R.

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
[Crossref] [PubMed]

Villringer, A.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Vroomen, P. C. A. J.

M. J. H. Aries, J. W. Elting, J. De Keyser, B. P. H. Kremer, and P. C. A. J. Vroomen, “Cerebral autoregulation in stroke: A review of transcranial doppler studies,” Stroke 41, 2697–2704 (2010).
[Crossref] [PubMed]

Wabnitz, H.

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

Wang, J.

Wechsler, L.

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Wintermark, M.

B. P. Soares, J. D. Chien, and M. Wintermark, “MR and CT monitoring of recanalization, reperfusion, and penumbra salvage: Everything that recanalizes does not necessarily reperfuse!” Stroke 40, 24–28 (2009).
[Crossref]

Witte, O. W.

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

Wojner, A. W.

I. Christou, A. V. Alexandrov, W. S. Burgin, A. W. Wojner, R. A. Felberg, M. Malkoff, J. C. Grotta, A. Felberg, M. Malkoff, J. C. Grotta, I. Christou, A. V. Alexandrov, and W. S. Burgin, “Timing of recanalization after tissue plasminogen activator therapy determined by transcranial doppler correlates with clinical recovery from ischemic stroke,” Stroke. 31, 1812–1816 (2000).
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Yodh, A. G.

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

C. G. Favilla, R. C. Mesquita, M. Mullen, T. Durduran, X. Lu, M. N. Kim, D. L. Minkoff, S. E. Kasner, J. H. Greenberg, A. G. Yodh, and J. A. Detre, “Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation,” Stroke 45, 1269–1274 (2014).
[Crossref] [PubMed]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85, 51–63 (2014).
[Crossref]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73, 76701 (2010).
[Crossref]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[Crossref] [PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[Crossref] [PubMed]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75, 1855 (1995).
[Crossref] [PubMed]

Yu, G.

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[Crossref] [PubMed]

Zaccanti, G.

Zhou, C.

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29, 1766–1768 (2004).
[Crossref] [PubMed]

Zirak, P.

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, L. Dinia, J. Martí-Fàbregas, and T. Durduran, “Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion,” Acad. Radiol. 21, 168–174 (2014).
[Crossref] [PubMed]

P. Zirak, R. Delgado-Mederos, J. Martí-Fàbregas, and T. Durduran, “Effects of acetazolamide on the micro- and macro-vascular cerebral hemodynamics: a diffuse optical and transcranial doppler ultrasound study,” Biomed. Opt. Express 1, 1443–1459 (2010).
[Crossref]

Zucchelli, L.

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

Acad. Radiol. (1)

P. Zirak, R. Delgado-Mederos, L. Dinia, J. Martí-Fàbregas, and T. Durduran, “Microvascular versus macrovascular cerebral vasomotor reactivity in patients with severe internal carotid artery stenosis or occlusion,” Acad. Radiol. 21, 168–174 (2014).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (1)

Eur. Neurol. (1)

C. Terborg, K. Gröschel, A. Petrovitch, T. Ringer, S. Schnaudigel, O. W. Witte, and A. Kastrup, “Noninvasive assessment of cerebral perfusion and oxygenation in acute ischemic stroke by near-infrared spectroscopy,” Eur. Neurol. 62, 338–343 (2009).
[Crossref] [PubMed]

J. Biomed. Opt. (1)

P. Zirak, R. Delgado-Mederos, L. Dinia, D. Carrera, J. Martí-Fàbregas, and T. Durduran, “Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke,” J. Biomed. Opt. 19, 18002 (2014).
[Crossref] [PubMed]

J. Cereb. Blood Flow Metab. (1)

C. Hametner, P. Stanarcevic, S. Stampfl, S. Rohde, R. Veltkamp, and J. Bösel, “Noninvasive cerebral oximetry during endovascular therapy for acute ischemic stroke: an observational study,” J. Cereb. Blood Flow Metab. 35, 1722–1728 (2015).
[Crossref] [PubMed]

J. Clin. Monit. Comput. (1)

T. Ritzenthaler, T. H. Cho, D. Luis, Y. Berthezene, and N. Nighoghossian, “Usefulness of near-infrared spectroscopy in thrombectomy monitoring,” J. Clin. Monit. Comput. 29, 585–589 (2015).
[Crossref]

Neurocrit. Care (1)

M. N. Kim, B. L. Edlow, T. Durduran, S. Frangos, R. C. Mesquita, J. M. Levine, J. H. Greenberg, and G. Arjun, “Continuous optical monitoring of cerebral hemodynamics during head-of-bed manipulation in brain-injured adults,” Neurocrit. Care 20, 443–453 (2014).
[Crossref]

Neuroimage (4)

M. Ferrari and V. Quaresima, “A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application,” Neuroimage 63, 921–935 (2012).

A. Liebert, H. Wabnitz, J. Steinbrink, M. Möller, R. Macdonald, H. Rinneberg, A. Villringer, and H. Obrig, “Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance,” Neuroimage 24, 426–435 (2005).
[Crossref] [PubMed]

T. Durduran and A. G. Yodh, “Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement,” Neuroimage 85, 51–63 (2014).
[Crossref]

A. Torricelli, D. Contini, A. Pifferi, M. Caffini, R. Re, L. Zucchelli, and L. Spinelli, “Time domain functional NIRS imaging for human brain mapping,” Neuroimage 85, 28–50 (2014).
[Crossref]

Neurology (1)

M. Sloan, A. Alexandrov, C. Tegeler, M. Spencer, L. Caplan, E. Feldmann, L. Wechsler, D. Newell, C. Gomez, V. Babikian, D. Lefkowitz, R. Goldman, C. Armon, C. Hsu, and D. Goodin, “Assessment: transcranial Doppler ultrasonography: report of the T therapeutics and technology assessment subcommittee of the american academy of neurology,” Neurology 62, 1468–1481 (2004).
[Crossref] [PubMed]

Neurophotonics (2)

J. Selb, D. A. Boas, S.-T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1, 015005 (2014).
[Crossref] [PubMed]

W. B. Baker, A. B. Parthasarathy, T. S. Ko, D. R. Busch, K. Abramson, S.-Y. Tzeng, R. C. Mesquita, T. Durduran, J. H. Greenberg, D. K. Kung, and A. G. Yodh, “Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts,” Neurophotonics 2, 035004 (2015).
[Crossref] [PubMed]

Opt. Lett. (1)

Pediatr. Res. (1)

A. Duncan, J. H. Meek, M. Clemence, C. E. Elwell, P. Fallon, L. Tyszczuk, M. Cope, and D. T. Delpy, “Measurement of cranial optical path length as a function of age using phase resolved near infrared spectroscopy,” Pediatr. Res. 39, 889–894 (1996).
[Crossref] [PubMed]

Philos. Trans. A. Math. Phys. Eng. Sci. (1)

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos. Trans. A. Math. Phys. Eng. Sci. 369, 4390–4406 (2011).
[Crossref] [PubMed]

Phys. Med. Biol. (1)

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46, 2053–2065 (2001).
[Crossref] [PubMed]

Phys. Rev. Lett. (1)

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and imaging with diffusing temporal field correlations,” Phys. Rev. Lett. 75, 1855 (1995).
[Crossref] [PubMed]

Physiol. Meas. (1)

S. Kohri, Y. Hoshi, M. Tamura, C. Kato, Y. Kuge, and N. Tamaki, “Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study,” Physiol. Meas. 23, 301–312 (2002).
[Crossref] [PubMed]

Rep. Prog. Phys. (1)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73, 76701 (2010).
[Crossref]

Stroke (7)

D. A. De Silva, J. N. Fink, S. Christensen, M. Ebinger, C. Bladin, C. R. Levi, M. Parsons, K. Butcher, P. A. Barber, G. A. Donnan, and S. M. Davis, “Assessing reperfusion and recanalization as markers of clinical outcomes after intravenous thrombolysis in the echoplanar imaging thrombolytic evaluation trial (EPITHET),” Stroke 40, 2872–2874 (2009).
[Crossref] [PubMed]

T. H. Cho, N. Nighoghossian, I. K. Mikkelsen, L. Derex, M. Hermier, S. Pedraza, J. Fiehler, L. Østergaard, Y. Berthezène, and J. C. Baron, “Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome,” Stroke 46, 1582–1589 (2015).
[Crossref] [PubMed]

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Figures (2)

Fig. 1
Fig. 1 The schematic of the source-detector separation of the optical probe (left). The placement of the optical probes bilaterally on the forehead (right).
Fig. 2
Fig. 2 Frontal microvascular relative cerebral blood flow (rCBF), total hemoglobin concentration (THC), oxy-hemoglobin (HbO2), and deoxy-hemoglobin (Hb) changes over time are shown for the ipsilesional hemisphere (left column) and the contralesional hemisphere (right column) for all five patients (each patient in different color). (Δ) indicates a change of the optical variable from the baseline. Black line shows the fitted linear model of all the measurement points plotted. The time, x-axis, shows the time elapsed from the rtPA treatment onset. (*) indicates a statistically significant positive slope (p<0.05).

Tables (1)

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Table 1 Clinical and optical variables for each individual patient and also for the group.

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