Abstract

Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative micro-elastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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    [Crossref] [PubMed]
  27. G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
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  30. B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
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    [Crossref]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref]
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    [Crossref] [PubMed]

2017 (8)

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
[Crossref] [PubMed]

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

S. Luo, J. Yang, Q. Gao, S. Zhou, and C. A. Zhan, “The edge detectors suitable for retinal OCT image segmentation,” J. Healthc. Eng. 2017, 3978410 (2017).
[Crossref] [PubMed]

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref] [PubMed]

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

Q. Fang, L. Frewer, P. Wijesinghe, W. M. Allen, L. Chin, J. Hamzah, D. D. Sampson, A. Curatolo, and B. F. Kennedy, “Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces,” Opt. Lett. 42(7), 1233–1236 (2017).
[Crossref] [PubMed]

2016 (4)

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

Y. Qiu, F. R. Zaki, N. Chandra, S. A. Chester, and X. Liu, “Nonlinear characterization of elasticity using quantitative optical coherence elastography,” Biomed. Opt. Express 7(11), 4702–4710 (2016).
[Crossref] [PubMed]

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

2015 (7)

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

M. Singh, C. Wu, C.-H. Liu, J. Li, A. Schill, A. Nair, and K. V. Larin, “Phase-sensitive optical coherence elastography at 1.5 million A-Lines per second,” Opt. Lett. 40(11), 2588–2591 (2015).
[Crossref] [PubMed]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

2014 (6)

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

R. Patel, A. Khan, R. Quinlan, and A. N. Yaroslavsky, “Polarization-sensitive multimodal imaging for detecting breast cancer,” Cancer Res. 74(17), 4685–4693 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

2013 (3)

A. C. Chan, E. Y. Lam, and V. J. Srinivasan, “Comparison of Kasai autocorrelation and maximum likelihood estimators for Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 32(6), 1033–1042 (2013).
[Crossref] [PubMed]

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

2012 (3)

2010 (1)

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

2009 (2)

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

2008 (1)

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

2007 (1)

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

2006 (1)

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

1998 (1)

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

1986 (1)

J. Canny, “A computational approach to edge detection,” IEEE Trans. Pattern Anal. Mach. Intell. 8(6), 679–698 (1986).
[Crossref] [PubMed]

Adams, B. J.

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

Adie, S. G.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Aguirre, A. D.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Allen, W. M.

Ames, F. C.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Babiera, G. V.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Ballal, H.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Barry, W. T.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Bear, H. D.

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

Bellafiore, F. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Bisaillon, C.-E.

Boppart, S. A.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Bourke, A. G.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Brown, C. N.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

Brown, J. Q.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Buchanan, M.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Buchholz, T. A.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Bush, M. B.

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

Bydlon, T. M.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Cabioglu, N.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Caddy, C. M.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Campbell, G.

Canner, J. K.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
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Canny, J.

J. Canny, “A computational approach to edge detection,” IEEE Trans. Pattern Anal. Mach. Intell. 8(6), 679–698 (1986).
[Crossref] [PubMed]

Chan, A. C.

A. C. Chan, E. Y. Lam, and V. J. Srinivasan, “Comparison of Kasai autocorrelation and maximum likelihood estimators for Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 32(6), 1033–1042 (2013).
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Chandra, N.

Chandrasekaran, S. N.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

Chaney, E. J.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Chang, E.

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
[Crossref] [PubMed]

Chen, K.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Chen, Y.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Chester, S. A.

Chin, L.

Q. Fang, L. Frewer, P. Wijesinghe, W. M. Allen, L. Chin, J. Hamzah, D. D. Sampson, A. Curatolo, and B. F. Kennedy, “Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces,” Opt. Lett. 42(7), 1233–1236 (2017).
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L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
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W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
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B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
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K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
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B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
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K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
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B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Chitnavis, P.

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

Cittadine, A. J.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Cohen, D. W.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Collins, J. P.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Connolly, J. L.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Cradock, K. A.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Cromwell, D. A.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Crowe, J. P.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Curatolo, A.

Dantuono, J. T.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

Darga, D.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Dasari, R. R.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Dong, L.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

Du, Y.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Erickson-Bhatt, S. J.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Es’haghian, S.

Fan, Z.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Fang, Q.

Feig, B. W.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Feld, M. S.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Feldman, S.

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
[Crossref] [PubMed]

Fitzmaurice, M.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Ford, C.

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

Frewer, L.

Fujimoto, J. G.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Gabrielson, E.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Gallagher, J.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Gan, Y.

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
[Crossref] [PubMed]

Gao, P.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Gao, Q.

S. Luo, J. Yang, Q. Gao, S. Zhou, and C. A. Zhan, “The edge detectors suitable for retinal OCT image segmentation,” J. Healthc. Eng. 2017, 3978410 (2017).
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Gardecki, J. A.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
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Garra, B. S.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
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Geradts, J.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Glaser, A. K.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Gruen, R. L.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Haka, A. S.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Hall, T.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Hamzah, J.

Han, B.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Hendon, C.

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
[Crossref] [PubMed]

Hibshoosh, H.

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
[Crossref] [PubMed]

Hicks, D.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Hunt, K. K.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Jacobs, L. K.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Jeevan, R.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Johnson, P. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Junker, M. K.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Kallel, F.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Kearins, O.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Kennedy, B. F.

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

Q. Fang, L. Frewer, P. Wijesinghe, W. M. Allen, L. Chin, J. Hamzah, D. D. Sampson, A. Curatolo, and B. F. Kennedy, “Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces,” Opt. Lett. 42(7), 1233–1236 (2017).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

Kennedy, K. M.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

Kennedy, S. A.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Khan, A.

R. Patel, A. Khan, R. Quinlan, and A. N. Yaroslavsky, “Polarization-sensitive multimodal imaging for detecting breast cancer,” Cancer Res. 74(17), 4685–4693 (2014).
[Crossref] [PubMed]

Kirk, R. W.

Koh, S. H.

Kotynek, J. G.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Krouskop, T. A.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Kuerer, H. M.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Kurniawan, E. D.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Lam, E. Y.

A. C. Chan, E. Y. Lam, and V. J. Srinivasan, “Comparison of Kasai autocorrelation and maximum likelihood estimators for Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 32(6), 1033–1042 (2013).
[Crossref] [PubMed]

Lamouche, G.

Larin, K. V.

Latham, B.

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Lawrence, G.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Lee, H.-C.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Li, J.

Liu, C.-H.

Liu, J. T.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Liu, X.

Liu, Z. G.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Luo, S.

S. Luo, J. Yang, Q. Gao, S. Zhou, and C. A. Zhan, “The edge detectors suitable for retinal OCT image segmentation,” J. Healthc. Eng. 2017, 3978410 (2017).
[Crossref] [PubMed]

Lyons, J.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Malheiro, F. G.

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

Mann, G. B.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Marjanovic, M.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

May Gonzalez, E. A.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

McCarty, E. F.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

McCormick, D. T.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

McLaughlin, R. A.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

Meric-Bernstam, F.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Miller, J. A.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Mondelblatt, A. E.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Monroy, G. L.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Mou, A.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Mulligan, J. A.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

Munro, P. R.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

Munro, P. R. T.

Nair, A.

Nazemi, J.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Nguyen, F. T.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Nolan, R. M.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Oberai, A. A.

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

Oliphant, U. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Patel, R.

R. Patel, A. Khan, R. Quinlan, and A. N. Yaroslavsky, “Polarization-sensitive multimodal imaging for detecting breast cancer,” Cancer Res. 74(17), 4685–4693 (2014).
[Crossref] [PubMed]

Pazos, V.

Pereira, J.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Putney, J.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Qiu, Y.

Quinlan, R.

R. Patel, A. Khan, R. Quinlan, and A. N. Yaroslavsky, “Polarization-sensitive multimodal imaging for detecting breast cancer,” Cancer Res. 74(17), 4685–4693 (2014).
[Crossref] [PubMed]

Ramanujam, N.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Ray, P. S.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Reder, N. P.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Richards, L. M.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Ronald, M.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

Rose, A.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Ross, M. I.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Rowland, K. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Sahin, A. A.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Sampson, D. D.

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref] [PubMed]

Q. Fang, L. Frewer, P. Wijesinghe, W. M. Allen, L. Chin, J. Hamzah, D. D. Sampson, A. Curatolo, and B. F. Kennedy, “Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces,” Opt. Lett. 42(7), 1233–1236 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

Saunders, C. M.

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref] [PubMed]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

Sawyer, K.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Schill, A.

Schneider, E. B.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Scolaro, L.

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

Scott Carney, P.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Shemonski, N. D.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Sheppard, C.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Singh, M.

Singletary, S. E.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

South, F. A.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Srinivasan, V. J.

A. C. Chan, E. Y. Lam, and V. J. Srinivasan, “Comparison of Kasai autocorrelation and maximum likelihood estimators for Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 32(6), 1033–1042 (2013).
[Crossref] [PubMed]

Stevenson, C.

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

Sundaram, M.

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

Tafra, L.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Taylor, D. B.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Tien, A.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Trivella, M.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

True, L. D.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Tsai, T.-H.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Tsuchiya, K.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

Untracht, G. R.

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

van der Meulen, J. H.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Volynskaya, Z.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Wang, Y.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Wei, L.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Wheeler, T. M.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Whitman, G. J.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Wijesinghe, P.

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

Q. Fang, L. Frewer, P. Wijesinghe, W. M. Allen, L. Chin, J. Hamzah, D. D. Sampson, A. Curatolo, and B. F. Kennedy, “Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces,” Opt. Lett. 42(7), 1233–1236 (2017).
[Crossref] [PubMed]

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
[Crossref]

W. M. Allen, L. Chin, P. Wijesinghe, R. W. Kirk, B. Latham, D. D. Sampson, C. M. Saunders, and B. F. Kennedy, “Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins,” Biomed. Opt. Express 7(10), 4139–4153 (2016).
[Crossref] [PubMed]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

Wilke, L. G.

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Windle, I.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Wolfe, L.

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

Wong, M. H.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Wu, C.

Xu, W.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Yang, J.

S. Luo, J. Yang, Q. Gao, S. Zhou, and C. A. Zhan, “The edge detectors suitable for retinal OCT image segmentation,” J. Healthc. Eng. 2017, 3978410 (2017).
[Crossref] [PubMed]

Yao, X.

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
[Crossref] [PubMed]

Yaroslavsky, A. N.

R. Patel, A. Khan, R. Quinlan, and A. N. Yaroslavsky, “Polarization-sensitive multimodal imaging for detecting breast cancer,” Cancer Res. 74(17), 4685–4693 (2014).
[Crossref] [PubMed]

Yin, C.

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Yu, Z.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Zaki, F. R.

Zhan, C. A.

S. Luo, J. Yang, Q. Gao, S. Zhou, and C. A. Zhan, “The edge detectors suitable for retinal OCT image segmentation,” J. Healthc. Eng. 2017, 3978410 (2017).
[Crossref] [PubMed]

Zhao, G.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Zheng, C.

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Zhou, C.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Zhou, S.

S. Luo, J. Yang, Q. Gao, S. Zhou, and C. A. Zhan, “The edge detectors suitable for retinal OCT image segmentation,” J. Healthc. Eng. 2017, 3978410 (2017).
[Crossref] [PubMed]

Zoon, C. K.

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

Zysk, A. M.

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Am. J. Surg. (1)

L. G. Wilke, J. Q. Brown, T. M. Bydlon, S. A. Kennedy, L. M. Richards, M. K. Junker, J. Gallagher, W. T. Barry, J. Geradts, and N. Ramanujam, “Rapid noninvasive optical imaging of tissue composition in breast tumor margins,” Am. J. Surg. 198(4), 566–574 (2009).
[Crossref] [PubMed]

Ann. Surg. Oncol. (4)

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

B. J. Adams, C. K. Zoon, C. Stevenson, P. Chitnavis, L. Wolfe, and H. D. Bear, “The role of margin status and reexcision in local recurrence following breast conservation surgery,” Ann. Surg. Oncol. 20(7), 2250–2255 (2013).
[Crossref] [PubMed]

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

A. M. Zysk, K. Chen, E. Gabrielson, L. Tafra, E. A. May Gonzalez, J. K. Canner, E. B. Schneider, A. J. Cittadine, P. Scott Carney, S. A. Boppart, K. Tsuchiya, K. Sawyer, and L. K. Jacobs, “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).
[Crossref] [PubMed]

ANZ J. Surg. (1)

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Biomed. Opt. Express (5)

BMJ (1)

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345(jul12 2), e4505 (2012).
[Crossref] [PubMed]

Cancer Res. (6)

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

S. J. Erickson-Bhatt, R. M. Nolan, N. D. Shemonski, S. G. Adie, J. Putney, D. Darga, D. T. McCormick, A. J. Cittadine, A. M. Zysk, M. Marjanovic, E. J. Chaney, G. L. Monroy, F. A. South, K. A. Cradock, Z. G. Liu, M. Sundaram, P. S. Ray, and S. A. Boppart, “Real-time imaging of the resection bed using a handheld probe to reduce incidence of microscopic positive margins in cancer surgery,” Cancer Res. 75(18), 3706–3712 (2015).
[Crossref] [PubMed]

R. Patel, A. Khan, R. Quinlan, and A. N. Yaroslavsky, “Polarization-sensitive multimodal imaging for detecting breast cancer,” Cancer Res. 74(17), 4685–4693 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (3)

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A review of optical coherence elastography: fundamentals, techniques and prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

J. A. Mulligan, G. R. Untracht, S. N. Chandrasekaran, C. N. Brown, and S. G. Adie, “Emerging approaches for high-resolution imaging of tissue biomechanics with optical coherence elastography,” IEEE J. Sel. Top. Quantum Electron. 22(3), 246–265 (2016).
[Crossref]

L. Dong, P. Wijesinghe, J. T. Dantuono, D. D. Sampson, P. R. Munro, B. F. Kennedy, and A. A. Oberai, “Quantitative compression optical coherence elastography as an inverse elasticity problem,” IEEE J. Sel. Top. Quantum Electron. 22(3), 277–287 (2016).
[Crossref]

IEEE Trans. Med. Imaging (1)

A. C. Chan, E. Y. Lam, and V. J. Srinivasan, “Comparison of Kasai autocorrelation and maximum likelihood estimators for Doppler optical coherence tomography,” IEEE Trans. Med. Imaging 32(6), 1033–1042 (2013).
[Crossref] [PubMed]

IEEE Trans. Pattern Anal. Mach. Intell. (1)

J. Canny, “A computational approach to edge detection,” IEEE Trans. Pattern Anal. Mach. Intell. 8(6), 679–698 (1986).
[Crossref] [PubMed]

J. Biomed. Opt. (2)

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

J. Biophotonics (1)

L. Chin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography,” J. Biophotonics 10(5), 690–700 (2017).
[Crossref] [PubMed]

J. Healthc. Eng. (1)

S. Luo, J. Yang, Q. Gao, S. Zhou, and C. A. Zhan, “The edge detectors suitable for retinal OCT image segmentation,” J. Healthc. Eng. 2017, 3978410 (2017).
[Crossref] [PubMed]

J. Lightwave Technol. (1)

J. R. Soc. Interface (1)

P. Wijesinghe, D. D. Sampson, and B. F. Kennedy, “Computational optical palpation: a finite-element approach to micro-scale tactile imaging using a compliant sensor,” J. R. Soc. Interface 14(128), 20160878 (2017).
[Crossref] [PubMed]

J. Spectrosc. (1)

P. Gao, B. Han, Y. Du, G. Zhao, Z. Yu, W. Xu, C. Zheng, and Z. Fan, “The clinical application of Raman spectroscopy for breast cancer detection,” J. Spectrosc. 2017, 5383948 (2017).
[Crossref]

Lasers Surg. Med. (1)

X. Yao, Y. Gan, E. Chang, H. Hibshoosh, S. Feldman, and C. Hendon, “Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT,” Lasers Surg. Med. 49(3), 258–269 (2017).
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Nat. Biomed. Eng. (1)

A. K. Glaser, N. P. Reder, Y. Chen, E. F. McCarty, C. Yin, L. Wei, Y. Wang, L. D. True, and J. T. Liu, “Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens,” Nat. Biomed. Eng. 1(7), s41551 (2017).
[Crossref]

Nat. Photonics (1)

B. F. Kennedy, P. Wijesinghe, and D. D. Sampson, “The emergence of optical elastography in biomedicine,” Nat. Photonics 11(4), 215–221 (2017).
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Opt. Lett. (3)

Photonics Lasers Med. (1)

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
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K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5(1), 15538 (2015).
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Supplementary Material (4)

NameDescription
» Visualization 1       Wide-field quantitative micro-elastography of a freshly excised mastectomy specimen containing invasive ductal carcinoma.
» Visualization 2       Wide-field quantitative micro-elastography of a freshly excised mastectomy specimen containing invasive ductal carcinoma.
» Visualization 3       Wide-field quantitative micro-elastography of a freshly excised mastectomy specimen containing ductal carcinoma in situ.
» Visualization 4       Wide-field quantitative micro-elastography of a freshly excised mastectomy specimen containing invasive ductal carcinoma and ductal carcinoma in situ.

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Figures (5)

Fig. 1
Fig. 1 Wide-field QME experimental setup. (a) Photograph of wide-field probe with three main elements labeled. (b) Schematic of loaded specimen. (c) Example of unstitched en face OCT images of mastectomy specimen.
Fig. 2
Fig. 2 Wide-field QME of a freshly excised mastectomy specimen (see Visualization 1). (a) Specimen photograph. (b) Histology. (c) Magnified histology. (d) Wide-field en face OCT. (e) Wide-field en face qualitative micro-elastogram. (f) Wide-field en face quantitative micro-elastogram. (g) Magnified en face OCT. (h) OCT B-scan in the plane indicated by dashed line in (g). (i) Magnified en face qualitative micro-elastogram. (j) Magnified en face quantitative micro-elastogram. A, adipose; C, cavity; E, edge detection artifact; G, coherence gate curvature artifact; T, invasive tumor; R, specular reflection; S, uninvolved stroma.
Fig. 3
Fig. 3 Wide-field OCME and QME of freshly excised mastectomy specimen containing invasive ductal carcinoma (see Visualization 2). (a) Photograph and (b) histology of specimen; black square indicates the scanned area. (c) Magnified histology. En face (d) OCT and (e) qualitative micro-elastogram from wide-field OCME. Magnified en face (f) OCT and (g) qualitative micro-elastogram from wide-field OCME. En face (h) OCT, (i) qualitative micro-elastogram, and (j) quantitative micro-elastogram from wide-field QME. Magnified en face (k) OCT, (l) qualitative micro-elastogram, and (m) quantitative micro-elastogram from wide-field QME. A, adipose; T, invasive tumor; NC, non-contact; S, uninvolved stroma.
Fig. 4
Fig. 4 Wide-field QME of a freshly excised mastectomy specimen containing ductal carcinoma in situ (DCIS) (see Visualization 3). (a) Photograph and (b) histology of specimen; black square indicates the scanned area. (c) Magnified histology. (d) Wide-field en face OCT image. (e) Wide-field en face qualitative micro-elastogram. (f) Wide-field en face quantitative micro-elastogram. (g) Magnified en face OCT. (h) Magnified en face qualitative micro-elastogram. (i) Magnified en face quantitative micro-elastogram. A, adipose; D, DCIS; FC, DCIS with focal calcification; N, DCIS with necrosis; S, stroma.
Fig. 5
Fig. 5 Wide-field QME of freshly excised mastectomy specimen containing invasive ductal carcinoma and DCIS (See Visualization 4). (a) Photograph of preloaded specimen. (b) Histology. (c) Magnified histology. (d) Wide-field en face OCT. (e) Wide-field en face qualitative micro-elastogram. (f) Wide-field en face quantitative micro-elastogram. (g) Magnified en face OCT. (h) Plot of OCT SNR. (i) Magnified en face qualitative micro-elastogram. (j) Plot of strain. (k) Magnified en face quantitative micro-elastogram. (l) Plot of elasticity. A, Adipose; D, DCIS; P, Paucicellular desmoplastic stroma; T, Invasive ductal carcinoma; S, Uninvolved stroma. Plot location indicated by dashed lines in (g), (i) and (k). The upper and lower boundaries of the duct are indicated by the dashed black horizontal lines across (g)-(l)

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