Abstract

A novel detection chain, based on 8 Silicon Photomultipliers (forming a wide-area custom-made detection probe) and on a time-to-digital converter, was developed to improve the signal level in multi-wavelength (635-1060 nm) time domain optical mammography. The performances of individual components and of the overall chain were assessed using established protocols (BIP and MEDPHOT). The photon detection efficiency was improved by up to 3 orders of magnitude, and the maximum count rate level was increased by a factor of 10 when compared to the previous system, based on photomultiplier tubes and conventional time-correlated single-photon counting boards. In the estimate of optical parameters, the novel detection chain provides performances comparable to the previous system, widely validated in clinics, but with higher signal level, higher robustness, and at a lower price per channel, thus targeting important requirements for clinical applications.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
OSA Recommended Articles
Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics

Alberto Dalla Mora, Edoardo Martinenghi, Davide Contini, Alberto Tosi, Gianluca Boso, Turgut Durduran, Simon Arridge, Fabrizio Martelli, Andrea Farina, Alessandro Torricelli, and Antonio Pifferi
Opt. Express 23(11) 13937-13946 (2015)

A spread spectrum approach to time-domain near-infrared diffuse optical imaging using inexpensive optical transceiver modules

Konstantinos I. Papadimitriou, Laura A. Dempsey, Jeremy C. Hebden, Simon R. Arridge, and Samuel Powell
Biomed. Opt. Express 9(6) 2648-2663 (2018)

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Rebecca Re, Davide Contini, Massimo Turola, Lorenzo Spinelli, Lucia Zucchelli, Matteo Caffini, Rinaldo Cubeddu, and Alessandro Torricelli
Biomed. Opt. Express 4(10) 2231-2246 (2013)

References

  • View by:
  • |
  • |
  • |

  1. T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
    [Crossref] [PubMed]
  2. W. Becker, Advanced Time-Correlated Single Photon Counting Techniques (Springer, 2005), Vol. 81.
  3. W. Becker, The Bh TCSPC Handbook, 7th ed. (2017).
  4. D. Grosenick, H. Rinneberg, R. Cubeddu, and P. Taroni, “Review of optical breast imaging and spectroscopy,” J. Biomed. Opt. 21(9), 091311 (2016).
    [Crossref] [PubMed]
  5. D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
    [Crossref] [PubMed]
  6. D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
    [Crossref] [PubMed]
  7. P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
    [Crossref] [PubMed]
  8. R. Choe and T. Durduran, “Diffuse Optical Monitoring of the Neoadjuvant Breast Cancer Therapy,” IEEE J. Sel. Top. Quantum Electron. 18(4), 1367–1386 (2012).
    [Crossref] [PubMed]
  9. Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
    [Crossref] [PubMed]
  10. D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
    [Crossref] [PubMed]
  11. P. Taroni, A. Pifferi, E. Salvagnini, L. Spinelli, A. Torricelli, and R. Cubeddu, “Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification,” Opt. Express 17(18), 15932–15946 (2009).
    [Crossref] [PubMed]
  12. J. C. Hebden, H. Veenstra, H. Dehghani, E. M. C. Hillman, M. Schweiger, S. R. Arridge, and D. T. Delpy, “Three-dimensional time-resolved optical tomography of a conical breast phantom,” Appl. Opt. 40(19), 3278–3287 (2001).
    [Crossref] [PubMed]
  13. G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
    [Crossref] [PubMed]
  14. P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
    [Crossref] [PubMed]
  15. P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
    [Crossref] [PubMed]
  16. A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
    [Crossref] [PubMed]
  17. A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
    [Crossref] [PubMed]
  18. E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
    [Crossref] [PubMed]
  19. F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
    [Crossref]
  20. H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
    [Crossref] [PubMed]
  21. A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
    [Crossref] [PubMed]
  22. B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
    [Crossref]
  23. E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
    [Crossref]
  24. A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
    [Crossref] [PubMed]
  25. S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
    [Crossref]
  26. A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
    [Crossref] [PubMed]
  27. R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
    [Crossref] [PubMed]

2016 (4)

D. Grosenick, H. Rinneberg, R. Cubeddu, and P. Taroni, “Review of optical breast imaging and spectroscopy,” J. Biomed. Opt. 21(9), 091311 (2016).
[Crossref] [PubMed]

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
[Crossref] [PubMed]

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

2015 (4)

A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
[Crossref] [PubMed]

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

2014 (4)

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

2013 (2)

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

2012 (2)

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

R. Choe and T. Durduran, “Diffuse Optical Monitoring of the Neoadjuvant Breast Cancer Therapy,” IEEE J. Sel. Top. Quantum Electron. 18(4), 1367–1386 (2012).
[Crossref] [PubMed]

2010 (1)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

2009 (1)

2008 (1)

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

2007 (1)

A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
[Crossref] [PubMed]

2006 (1)

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

2005 (2)

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

2001 (1)

1996 (1)

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
[Crossref] [PubMed]

Abbate, F.

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

Adams, A.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Andersson-Engels, S.

Arridge, S.

Arridge, S. R.

Athanasiou, T.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Avrillier, S.

Baker, W. B.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Balagura, V.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Balestreri, N.

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

Bargigia, I.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Bassi, A.

Boso, G.

Brockherde, W.

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Bronzi, D.

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Busch, D. R.

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

Buzhan, P. Z.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Caffini, M.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Cassano, E.

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

Choe, R.

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

R. Choe and T. Durduran, “Diffuse Optical Monitoring of the Neoadjuvant Breast Cancer Therapy,” IEEE J. Sel. Top. Quantum Electron. 18(4), 1367–1386 (2012).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Comelli, D.

A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
[Crossref] [PubMed]

Contini, D.

A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
[Crossref] [PubMed]

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
[Crossref] [PubMed]

A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref] [PubMed]

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Cooper, R.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Cubeddu, R.

D. Grosenick, H. Rinneberg, R. Cubeddu, and P. Taroni, “Review of optical breast imaging and spectroscopy,” J. Biomed. Opt. 21(9), 091311 (2016).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

P. Taroni, A. Pifferi, E. Salvagnini, L. Spinelli, A. Torricelli, and R. Cubeddu, “Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification,” Opt. Express 17(18), 15932–15946 (2009).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
[Crossref] [PubMed]

Dalla Mora, A.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Danilov, M. V.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Darzi, A.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

DeFusco, P.

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

Dehghani, H.

Delpy, D. T.

Di Sieno, L.

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

Dolgoshein, B. A.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Durduran, T.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref] [PubMed]

A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
[Crossref] [PubMed]

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

R. Choe and T. Durduran, “Diffuse Optical Monitoring of the Neoadjuvant Breast Cancer Therapy,” IEEE J. Sel. Top. Quantum Electron. 18(4), 1367–1386 (2012).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Durini, D.

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Elias, S. G.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Enfield, L. C.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Farina, A.

A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
[Crossref] [PubMed]

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref] [PubMed]

A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Farzam, P.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

Filatov, L. A.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Garutti, E.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Gebauer, B.

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

Gibson, A.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Groll, M.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Grosenick, D.

D. Grosenick, H. Rinneberg, R. Cubeddu, and P. Taroni, “Review of optical breast imaging and spectroscopy,” J. Biomed. Opt. 21(9), 091311 (2016).
[Crossref] [PubMed]

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

Hebden, J.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Hebden, J. C.

Hegde, P.

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

Hillman, E. M. C.

Ieva, F.

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

Ilyin, A. L.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Jelzow, A.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Kacprzak, M.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Kantserov, V. A.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Kaplin, V. A.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Karakash, A. I.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Kayumov, F. F.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Klemin, S. N.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Konugolu Venkata Sekar, S.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

Korbel, V.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Leff, D. R.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Liebert, A.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Lindner, C.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

Lussana, R.

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Macdonald, R.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

Mali, W. P. T. M.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Martelli, F.

Martinenghi, E.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
[Crossref] [PubMed]

A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref] [PubMed]

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

Mazurenka, M.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Menna, S.

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

Meyer, H. J.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Milej, D.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Mizuk, R. V.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Moesta, K. T.

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

Möller, M.

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

Mora, A. D.

Morgunov, V. L.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Mucke, J.

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

Nghiem, H. L.

Novikov, E. G.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Paganoni, A. M.

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

Pagliazzi, M.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

Pakhlov, P. N.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Patten, D. K.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Pearlman, P. C.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Pifferi, A.

A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
[Crossref] [PubMed]

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref] [PubMed]

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

P. Taroni, A. Pifferi, E. Salvagnini, L. Spinelli, A. Torricelli, and R. Cubeddu, “Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification,” Opt. Express 17(18), 15932–15946 (2009).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
[Crossref] [PubMed]

Pluim, J. P. W.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Popova, E. V.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Quarto, G.

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

Ricci, A.

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

Rinneberg, H.

D. Grosenick, H. Rinneberg, R. Cubeddu, and P. Taroni, “Review of optical breast imaging and spectroscopy,” J. Biomed. Opt. 21(9), 091311 (2016).
[Crossref] [PubMed]

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

Rusinov, V. Y.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Salvagnini, E.

Sanzaro, M.

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

Sawosz, P.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Schlag, P. M.

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

Schweiger, M.

Sefkow, F.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Spinelli, L.

A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
[Crossref] [PubMed]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, A. Pifferi, E. Salvagnini, L. Spinelli, A. Torricelli, and R. Cubeddu, “Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification,” Opt. Express 17(18), 15932–15946 (2009).
[Crossref] [PubMed]

Stamm, H.

Steinkellner, O.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Sterenborg, H. J. C. M.

Stroszczynski, C.

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

Svensson, T.

Swartling, J.

Tannenbaum, S.

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

Tarkovsky, E.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Taroni, P.

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

D. Grosenick, H. Rinneberg, R. Cubeddu, and P. Taroni, “Review of optical breast imaging and spectroscopy,” J. Biomed. Opt. 21(9), 091311 (2016).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

P. Taroni, A. Pifferi, E. Salvagnini, L. Spinelli, A. Torricelli, and R. Cubeddu, “Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification,” Opt. Express 17(18), 15932–15946 (2009).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
[Crossref] [PubMed]

Taubert, D. R.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Tikhomirov, I. N.

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Tisa, S.

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Torricelli, A.

A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
[Crossref] [PubMed]

A. D. Mora, E. Martinenghi, D. Contini, A. Tosi, G. Boso, T. Durduran, S. Arridge, F. Martelli, A. Farina, A. Torricelli, and A. Pifferi, “Fast silicon photomultiplier improves signal harvesting and reduces complexity in time-domain diffuse optics,” Opt. Express 23(11), 13937–13946 (2015).
[Crossref] [PubMed]

A. D. Mora, D. Contini, S. Arridge, F. Martelli, A. Tosi, G. Boso, A. Farina, T. Durduran, E. Martinenghi, A. Torricelli, and A. Pifferi, “Towards next-generation time-domain diffuse optics for extreme depth penetration and sensitivity,” Biomed. Opt. Express 6(5), 1749–1760 (2015).
[Crossref] [PubMed]

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

G. Quarto, L. Spinelli, A. Pifferi, A. Torricelli, R. Cubeddu, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and P. Taroni, “Estimate of tissue composition in malignant and benign breast lesions by time-domain optical mammography,” Biomed. Opt. Express 5(10), 3684–3698 (2014).
[Crossref] [PubMed]

P. Taroni, A. Pifferi, E. Salvagnini, L. Spinelli, A. Torricelli, and R. Cubeddu, “Seven-wavelength time-resolved optical mammography extending beyond 1000 nm for breast collagen quantification,” Opt. Express 17(18), 15932–15946 (2009).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
[Crossref] [PubMed]

Tosi, A.

Tualle, J.-M.

Valentini, G.

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
[Crossref] [PubMed]

van Veen, R. L. P.

Veenstra, H.

Viergever, M. A.

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Villa, F.

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Wabnitz, H.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, A. Bassi, P. Taroni, R. Cubeddu, H. Wabnitz, D. Grosenick, M. Möller, R. Macdonald, J. Swartling, T. Svensson, S. Andersson-Engels, R. L. P. van Veen, H. J. C. M. Sterenborg, J.-M. Tualle, H. L. Nghiem, S. Avrillier, M. Whelan, and H. Stamm, “Performance assessment of photon migration instruments: the MEDPHOT protocol,” Appl. Opt. 44(11), 2104–2114 (2005).
[Crossref] [PubMed]

Wang, L.

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

Warren, O. J.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Wassermann, B.

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

Weyers, S.

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Whelan, M.

Yang, G. Z.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Yodh, A. G.

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Zappa, F.

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

Zhu, Q.

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

Zucchelli, L.

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

Appl. Opt. (2)

Biomed. Opt. Express (2)

Breast Cancer Res. (1)

Q. Zhu, L. Wang, S. Tannenbaum, A. Ricci, P. DeFusco, and P. Hegde, “Pathologic response prediction to neoadjuvant chemotherapy utilizing pretreatment near-infrared imaging parameters and tumor pathologic criteria,” Breast Cancer Res. 16(5), 456–469 (2014).
[Crossref] [PubMed]

Breast Cancer Res. Treat. (1)

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: A systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (3)

R. Choe and T. Durduran, “Diffuse Optical Monitoring of the Neoadjuvant Breast Cancer Therapy,” IEEE J. Sel. Top. Quantum Electron. 18(4), 1367–1386 (2012).
[Crossref] [PubMed]

S. Konugolu Venkata Sekar, A. Dalla Mora, I. Bargigia, E. Martinenghi, C. Lindner, P. Farzam, M. Pagliazzi, T. Durduran, P. Taroni, A. Pifferi, and A. Farina, “Broadband (600-1350 nm) Time-Resolved Diffuse Optical Spectrometer for Clinical Use,” IEEE J. Sel. Top. Quantum Electron. 22(3), 7100609 (2016).
[Crossref]

F. Villa, R. Lussana, D. Bronzi, S. Tisa, A. Tosi, F. Zappa, A. Dalla Mora, D. Contini, D. Durini, S. Weyers, and W. Brockherde, “CMOS imager with 1024 SPADs and TDCS for single-photon timing and 3-D time-of-flight,” IEEE J. Sel. Top. Quantum Electron. 20(6), 3804810 (2014).
[Crossref]

IEEE Photonics J. (1)

E. Martinenghi, A. Dalla Mora, D. Contini, A. Farina, F. Villa, A. Torricelli, and A. Pifferi, “Spectrally Resolved Single-Photon Timing of Silicon Photomultipliers for Time-Domain Diffuse Spectroscopy,” IEEE Photonics J. 7(4), 6802512 (2015).
[Crossref]

J. Biomed. Opt. (5)

H. Wabnitz, D. R. Taubert, M. Mazurenka, O. Steinkellner, A. Jelzow, R. Macdonald, D. Milej, P. Sawosz, M. Kacprzak, A. Liebert, R. Cooper, J. Hebden, A. Pifferi, A. Farina, I. Bargigia, D. Contini, M. Caffini, L. Zucchelli, L. Spinelli, R. Cubeddu, and A. Torricelli, “Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol,” J. Biomed. Opt. 19(8), 086010 (2014).
[Crossref] [PubMed]

P. Taroni, G. Quarto, A. Pifferi, F. Ieva, A. M. Paganoni, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Optical identification of subjects at high risk for developing breast cancer,” J. Biomed. Opt. 18(6), 060507 (2013).
[Crossref] [PubMed]

A. Pifferi, D. Contini, A. D. Mora, A. Farina, L. Spinelli, and A. Torricelli, “New frontiers in time-domain diffuse optics, a review,” J. Biomed. Opt. 21(9), 091310 (2016).
[Crossref] [PubMed]

D. Grosenick, H. Rinneberg, R. Cubeddu, and P. Taroni, “Review of optical breast imaging and spectroscopy,” J. Biomed. Opt. 21(9), 091311 (2016).
[Crossref] [PubMed]

P. C. Pearlman, A. Adams, S. G. Elias, W. P. T. M. Mali, M. A. Viergever, and J. P. W. Pluim, “Mono- and multimodal registration of optical breast images,” J. Biomed. Opt. 17(8), 080901 (2012).
[Crossref] [PubMed]

Med. Phys. (1)

R. Cubeddu, A. Pifferi, P. Taroni, A. Torricelli, and G. Valentini, “Experimental test of theoretical models for time-resolved reflectance,” Med. Phys. 23(9), 1625–1633 (1996).
[Crossref] [PubMed]

Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. (1)

B. A. Dolgoshein, V. Balagura, P. Z. Buzhan, M. V. Danilov, L. A. Filatov, E. Garutti, M. Groll, A. L. Ilyin, V. A. Kantserov, V. A. Kaplin, A. I. Karakash, F. F. Kayumov, S. N. Klemin, V. Korbel, H. J. Meyer, R. V. Mizuk, V. L. Morgunov, E. G. Novikov, P. N. Pakhlov, E. V. Popova, V. Y. Rusinov, F. Sefkow, E. Tarkovsky, and I. N. Tikhomirov, “Status report on silicon photomultiplier development and its applications,” Nucl. Instruments Methods Phys. Res. Sect. A Accel. Spectrometers, Detect. Assoc. Equip. 563(2), 368–376 (2006).
[Crossref]

Opt. Express (2)

PET Clin. (1)

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

Phys. Med. Biol. (1)

D. Grosenick, K. T. Moesta, M. Möller, J. Mucke, H. Wabnitz, B. Gebauer, C. Stroszczynski, B. Wassermann, P. M. Schlag, and H. Rinneberg, “Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients,” Phys. Med. Biol. 50(11), 2429–2449 (2005).
[Crossref] [PubMed]

PLoS One (1)

P. Taroni, G. Quarto, A. Pifferi, F. Abbate, N. Balestreri, S. Menna, E. Cassano, and R. Cubeddu, “Breast tissue composition and its dependence on demographic risk factors for breast cancer: non-invasive assessment by Time Domain diffuse optical spectroscopy,” PLoS One 10(6), e0128941 (2015).
[Crossref] [PubMed]

Rep. Prog. Phys. (1)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse optics for tissue monitoring and tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Rev. Sci. Instrum. (2)

E. Martinenghi, L. Di Sieno, D. Contini, M. Sanzaro, A. Pifferi, and A. Dalla Mora, “Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems,” Rev. Sci. Instrum. 87(7), 073101 (2016).
[Crossref] [PubMed]

A. Pifferi, A. Torricelli, P. Taroni, D. Comelli, A. Bassi, and R. Cubeddu, “Fully automated time domain spectrometer for the absorption and scattering characterization of diffusive media,” Rev. Sci. Instrum. 78(5), 053103 (2007).
[Crossref] [PubMed]

Other (2)

W. Becker, Advanced Time-Correlated Single Photon Counting Techniques (Springer, 2005), Vol. 81.

W. Becker, The Bh TCSPC Handbook, 7th ed. (2017).

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (9)

Fig. 1
Fig. 1 Layout of the pre-existing instrument (top) and of the new detection chain (bottom). The red dashed line contours the set of components interested by the renewal process. The blue dashed line surrounds the detection elements and the green one the acquisition system.
Fig. 2
Fig. 2 The 8-channel SiPM probe (left) with the black shield that covers the probe during operation (center), and the detail of the PCB (right).
Fig. 3
Fig. 3 Layout diagram of the 8-channel SiPM probe. The dotted line delimits the active area, and the dashed line the package.
Fig. 4
Fig. 4 Diffuse responsivity of the previous detection chain (red circles) and new detection chain (blue triangles) vs wavelength.
Fig. 5
Fig. 5 a) Recorded DNL expressed in LSB. b) DNL effect on a DTOF raw curve (red) and the same curve processed with the proposed corrections A (blue) and B (yellow). The three curves are arbitrarily offset from one another for clarity.
Fig. 6
Fig. 6 Overlapping of the IRFs at 3 different wavelengths at 10 MHz laser repetition rate. The dashed black line (slightly shifted upward for clarity) is the sum of the 3 IRFs.
Fig. 7
Fig. 7 Stability test on the IRF integral number of counts N t o t (left) and first moment m 1 (right). N t o t 0 is the average integral after the end of the warm up period (5-9 hr). The dashed lines indicate the ranges of ± 0.5% (left) and ± 5 ps (right).
Fig. 8
Fig. 8 Relative error vs relative count rate on the estimate of a) μ a and b) μ s using the TCSPC board (red circles) and the TDC (blue squares). The laser repetition rate was 10 MHz.
Fig. 9
Fig. 9 Linearity plots reflecting the system linearity in a) absorption and b) scattering measurement; and coupling of c) scattering to absorption and d) absorption to scattering.

Tables (3)

Tables Icon

Table 1 Performance of the correction algorithms a

Tables Icon

Table 2 Relative error on the estimate of μ a a

Tables Icon

Table 3 Relative error on the estimate of μ s a

Metrics