Abstract

Blood clotting is a serious clinical complication of many medical procedures and disorders including surgery, catheterization, transplantation, extracorporeal circuits, infections, and cancer. This complication leads to high patient morbidity and mortality due to clot-induced pulmonary embolism, stroke, and in some cases heart attack. Despite the clear medical significance, little progress has been made in developing the methods for detection of circulating blood clots (CBCs), also called emboli. We recently demonstrated the application of in vivo photoacoustic (PA) flow cytometry (PAFC) with unfocused ultrasound transducers for detection of CBCs in small vessels in a mouse model. In the current study, we extend applicability of PAFC for detection of CBCs in relatively large (1.5-2 mm) and deep (up to 5-6 mm) blood vessels in rat and rabbit models using a high pulse rate 1064 nm laser and focused ultrasound transducer with a central hole for an optic fiber. Employing phantoms and chemical activation of clotting, we demonstrated PA identification of white, red, and mixed CBCs producing negative, positive, and mixed PA contrast in blood background, respectively. We confirmed that PAFC can detect both red and white CBCs induced by microsurgical procedures, such as a needle or catheter insertion, as well as stroke modeled by injection of artificial clots. Our results show great potential for a PAFC diagnostic platform with a wearable PA fiber probe for diagnosis of thrombosis and embolism in vivo that is impossible with existing techniques.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
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References

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    [Crossref] [PubMed]
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    [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  35. H. J. Jawad, M. Sarimollaoglu, A. S. Biris, and V. P. Zharov, “Dynamic blood flow phantom with negative and positive photoacoustic contrasts,” Biomed. Opt. Express 9(10), 4702–4713 (2018).
    [Crossref]
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2018 (1)

2017 (2)

M. Moothanchery and M. Pramanik, “Performance characterization of a switchable acoustic resolution and optical resolution photoacoustic microscopy system,” Sensors (Basel) 17(2), 357 (2017).
[Crossref] [PubMed]

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

2016 (3)

Y. A. Menyaev, K. A. Carey, D. A. Nedosekin, M. Sarimollaoglu, E. I. Galanzha, J. S. Stumhofer, and V. P. Zharov, “Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery,” Biomed. Opt. Express 7(9), 3643–3658 (2016).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

2015 (1)

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

2014 (4)

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
[Crossref] [PubMed]

A. Deng, T. Galanis, and M. G. Graham, “Venous thromboembolism in cancer patients,” Hosp Pract (1995) 42(5), 24–33 (2014).
[Crossref] [PubMed]

S. Park, C. Lee, J. Kim, and C. Kim, “Acoustic resolution photoacoustic microscopy,” Biomed. Eng. Lett. 4(3), 213–222 (2014).
[Crossref]

2013 (5)

W. Xing, L. Wang, K. Maslov, and L. V. Wang, “Integrated optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle,” Opt. Lett. 38(1), 52–54 (2013).
[Crossref] [PubMed]

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

R. Gerrah and O. David, “In vivo quantification of clot formation in extracorporeal circuits,” Stud. Health Technol. Inform. 184, 148–150 (2013).
[PubMed]

Y. A. Menyaev, D. A. Nedosekin, M. Sarimollaoglu, M. A. Juratli, E. I. Galanzha, V. V. Tuchin, and V. P. Zharov, “Optical clearing in photoacoustic flow cytometry,” Biomed. Opt. Express 4(12), 3030–3041 (2013).
[Crossref] [PubMed]

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

2012 (4)

E. I. Galanzha and V. P. Zharov, “Photoacoustic flow cytometry,” Methods 57(3), 280–296 (2012).
[Crossref] [PubMed]

G. W. Tormoen, K. M. Haley, R. L. Levine, and O. J. T. McCarty, “Do circulating tumor cells play a role in coagulation and thrombosis?” Front. Oncol. 2, 115 (2012).
[Crossref] [PubMed]

A. A. Khorana, “Cancer-associated thrombosis: updates and controversies,” Hematology (Am. Soc. Hematol. Educ. Program) 2012, 626–630 (2012).
[PubMed]

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

2011 (1)

E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
[Crossref] [PubMed]

2010 (1)

J. D. Marsh and S. G. Keyrouz, “Stroke prevention and treatment,” J. Am. Coll. Cardiol. 56(9), 683–691 (2010).
[Crossref] [PubMed]

2009 (2)

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

D. K. Dressler, “Death by clot: acute coronary syndromes, ischemic stroke, pulmonary embolism, and disseminated intravascular coagulation,” AACN Adv. Crit. Care 20(2), 166–176 (2009).
[Crossref] [PubMed]

2008 (3)

W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen, “Cardiovascular risk factors and venous thromboembolism: a meta-analysis,” Circulation 117(1), 93–102 (2008).
[Crossref] [PubMed]

C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
[Crossref] [PubMed]

T. Tsuruo, “Platelet aggregation in the formation of tumor metastasis,” Proc. of the Japan Academy 84, 189–198 (2008).

2006 (1)

L. Frank, C. Lebreton-Decoster, G. Godeau, B. Coulomb, and J. Jozefonvicz, “Dextran derivatives modulate collagen matrix organization in dermal equivalent,” J. Biomater. Sci. Polym. Ed. 17(5), 499–517 (2006).
[Crossref] [PubMed]

2005 (1)

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
[Crossref] [PubMed]

2004 (1)

P. Jurasz, D. Alonso-Escolano, and M. W. Radomski, “Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation,” Br. J. Pharmacol. 143(7), 819–826 (2004).
[Crossref] [PubMed]

2003 (2)

R. H. White, H. Zhou, and P. S. Romano, “Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures,” Thromb. Haemost. 90(3), 446–455 (2003).
[PubMed]

J. G. Geng, “Interaction of vascular endothelial cells with leukocytes, platelets and cancer cells in inflammation, thrombosis and cancer growth and metastasis,” Acta Pharmacol. Sin. 24(12), 1297–1300 (2003).
[PubMed]

2002 (3)

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Y. Yang, D. G. Grosset, Q. Li, A. Shuaib, and K. R. Lees, “Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model,” AJNR Am. J. Neuroradiol. 23(7), 1229–1236 (2002).
[PubMed]

S. Falati, P. Gross, G. Merrill-Skoloff, B. C. Furie, and B. Furie, “Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse,” Nat. Med. 8(10), 1175–1180 (2002).
[Crossref] [PubMed]

2001 (1)

J. C. Grotta and A. V. Alexandrov, “Preventing stroke: is preventing microemboli enough?” Circulation 103(19), 2321–2322 (2001).
[Crossref] [PubMed]

1991 (1)

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

Ageno, W.

W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen, “Cardiovascular risk factors and venous thromboembolism: a meta-analysis,” Circulation 117(1), 93–102 (2008).
[Crossref] [PubMed]

Alexandrov, A. V.

J. C. Grotta and A. V. Alexandrov, “Preventing stroke: is preventing microemboli enough?” Circulation 103(19), 2321–2322 (2001).
[Crossref] [PubMed]

Alonso-Escolano, D.

P. Jurasz, D. Alonso-Escolano, and M. W. Radomski, “Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation,” Br. J. Pharmacol. 143(7), 819–826 (2004).
[Crossref] [PubMed]

Anderson, F. A.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

Auer, R. A.

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

Baglin, C.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Barker-Collo, S. L.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Bauersachs, R. M.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Becattini, C.

W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen, “Cardiovascular risk factors and venous thromboembolism: a meta-analysis,” Circulation 117(1), 93–102 (2008).
[Crossref] [PubMed]

Beckers, M.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Bellou, A.

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
[Crossref] [PubMed]

Bennett, D. A.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Biris, A. S.

Blum, A.

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
[Crossref] [PubMed]

Bounameaux, H.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Brenner, B.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Brighton, T.

W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen, “Cardiovascular risk factors and venous thromboembolism: a meta-analysis,” Circulation 117(1), 93–102 (2008).
[Crossref] [PubMed]

Brilhante, D.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Büller, H. R.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Cai, C.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

Carey, K. A.

Coulomb, B.

L. Frank, C. Lebreton-Decoster, G. Godeau, B. Coulomb, and J. Jozefonvicz, “Dextran derivatives modulate collagen matrix organization in dermal equivalent,” J. Biomater. Sci. Polym. Ed. 17(5), 499–517 (2006).
[Crossref] [PubMed]

Dalen, J. E.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

David, O.

R. Gerrah and O. David, “In vivo quantification of clot formation in extracorporeal circuits,” Stud. Health Technol. Inform. 184, 148–150 (2013).
[PubMed]

Debourdeau, P.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Deng, A.

A. Deng, T. Galanis, and M. G. Graham, “Venous thromboembolism in cancer patients,” Hosp Pract (1995) 42(5), 24–33 (2014).
[Crossref] [PubMed]

Dent, J.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Dings, R. P. M.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Doucette, S.

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

Douek, P.

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
[Crossref] [PubMed]

Dressler, D. K.

D. K. Dressler, “Death by clot: acute coronary syndromes, ischemic stroke, pulmonary embolism, and disseminated intravascular coagulation,” AACN Adv. Crit. Care 20(2), 166–176 (2009).
[Crossref] [PubMed]

Emerson, M.

C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
[Crossref] [PubMed]

Falanga, A.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Falati, S.

S. Falati, P. Gross, G. Merrill-Skoloff, B. C. Furie, and B. Furie, “Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse,” Nat. Med. 8(10), 1175–1180 (2002).
[Crossref] [PubMed]

Farge, D.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Feigin, V. L.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Fong, Y.

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

Forcier, A.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

Frank, L.

L. Frank, C. Lebreton-Decoster, G. Godeau, B. Coulomb, and J. Jozefonvicz, “Dextran derivatives modulate collagen matrix organization in dermal equivalent,” J. Biomater. Sci. Polym. Ed. 17(5), 499–517 (2006).
[Crossref] [PubMed]

Furie, B.

S. Falati, P. Gross, G. Merrill-Skoloff, B. C. Furie, and B. Furie, “Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse,” Nat. Med. 8(10), 1175–1180 (2002).
[Crossref] [PubMed]

Furie, B. C.

S. Falati, P. Gross, G. Merrill-Skoloff, B. C. Furie, and B. Furie, “Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse,” Nat. Med. 8(10), 1175–1180 (2002).
[Crossref] [PubMed]

Galanis, T.

A. Deng, T. Galanis, and M. G. Graham, “Venous thromboembolism in cancer patients,” Hosp Pract (1995) 42(5), 24–33 (2014).
[Crossref] [PubMed]

Galanzha, E. I.

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

Y. A. Menyaev, K. A. Carey, D. A. Nedosekin, M. Sarimollaoglu, E. I. Galanzha, J. S. Stumhofer, and V. P. Zharov, “Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery,” Biomed. Opt. Express 7(9), 3643–3658 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

Y. A. Menyaev, D. A. Nedosekin, M. Sarimollaoglu, M. A. Juratli, E. I. Galanzha, V. V. Tuchin, and V. P. Zharov, “Optical clearing in photoacoustic flow cytometry,” Biomed. Opt. Express 4(12), 3030–3041 (2013).
[Crossref] [PubMed]

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

E. I. Galanzha and V. P. Zharov, “Photoacoustic flow cytometry,” Methods 57(3), 280–296 (2012).
[Crossref] [PubMed]

E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
[Crossref] [PubMed]

Geng, J. G.

J. G. Geng, “Interaction of vascular endothelial cells with leukocytes, platelets and cancer cells in inflammation, thrombosis and cancer growth and metastasis,” Acta Pharmacol. Sin. 24(12), 1297–1300 (2003).
[PubMed]

Gerotzafias, G. T.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Gerrah, R.

R. Gerrah and O. David, “In vivo quantification of clot formation in extracorporeal circuits,” Stud. Health Technol. Inform. 184, 148–150 (2013).
[PubMed]

Godeau, G.

L. Frank, C. Lebreton-Decoster, G. Godeau, B. Coulomb, and J. Jozefonvicz, “Dextran derivatives modulate collagen matrix organization in dermal equivalent,” J. Biomater. Sci. Polym. Ed. 17(5), 499–517 (2006).
[Crossref] [PubMed]

Goldberg, R. J.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

Gonsalves, J.

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

Graham, M. G.

A. Deng, T. Galanis, and M. G. Graham, “Venous thromboembolism in cancer patients,” Hosp Pract (1995) 42(5), 24–33 (2014).
[Crossref] [PubMed]

Griffin, R. J.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Gross, P.

S. Falati, P. Gross, G. Merrill-Skoloff, B. C. Furie, and B. Furie, “Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse,” Nat. Med. 8(10), 1175–1180 (2002).
[Crossref] [PubMed]

Grosset, D. G.

Y. Yang, D. G. Grosset, Q. Li, A. Shuaib, and K. R. Lees, “Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model,” AJNR Am. J. Neuroradiol. 23(7), 1229–1236 (2002).
[PubMed]

Grotta, J. C.

J. C. Grotta and A. V. Alexandrov, “Preventing stroke: is preventing microemboli enough?” Circulation 103(19), 2321–2322 (2001).
[Crossref] [PubMed]

Guillemin, F.

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
[Crossref] [PubMed]

Haim, N.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Haley, K. M.

G. W. Tormoen, K. M. Haley, R. L. Levine, and O. J. T. McCarty, “Do circulating tumor cells play a role in coagulation and thrombosis?” Front. Oncol. 2, 115 (2012).
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Heit, J. A.

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Hosmer, D. W.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

Jamshidi-Parsian, A.

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

Jawad, H. J.

Jones, S.

C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
[Crossref] [PubMed]

Jovanovic, B.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

Jozefonvicz, J.

L. Frank, C. Lebreton-Decoster, G. Godeau, B. Coulomb, and J. Jozefonvicz, “Dextran derivatives modulate collagen matrix organization in dermal equivalent,” J. Biomater. Sci. Polym. Ed. 17(5), 499–517 (2006).
[Crossref] [PubMed]

Jurasz, P.

P. Jurasz, D. Alonso-Escolano, and M. W. Radomski, “Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation,” Br. J. Pharmacol. 143(7), 819–826 (2004).
[Crossref] [PubMed]

Juratli, M. A.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

Y. A. Menyaev, D. A. Nedosekin, M. Sarimollaoglu, M. A. Juratli, E. I. Galanzha, V. V. Tuchin, and V. P. Zharov, “Optical clearing in photoacoustic flow cytometry,” Biomed. Opt. Express 4(12), 3030–3041 (2013).
[Crossref] [PubMed]

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

Juratli, T. A.

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
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D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
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W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen, “Cardiovascular risk factors and venous thromboembolism: a meta-analysis,” Circulation 117(1), 93–102 (2008).
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Keyrouz, S. G.

E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
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J. D. Marsh and S. G. Keyrouz, “Stroke prevention and treatment,” J. Am. Coll. Cardiol. 56(9), 683–691 (2010).
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Khorana, A. A.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
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A. A. Khorana, “Cancer-associated thrombosis: updates and controversies,” Hematology (Am. Soc. Hematol. Educ. Program) 2012, 626–630 (2012).
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S. Park, C. Lee, J. Kim, and C. Kim, “Acoustic resolution photoacoustic microscopy,” Biomed. Eng. Lett. 4(3), 213–222 (2014).
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Kim, J.

S. Park, C. Lee, J. Kim, and C. Kim, “Acoustic resolution photoacoustic microscopy,” Biomed. Eng. Lett. 4(3), 213–222 (2014).
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Koonce, N. A.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
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Laprévote-Heully, M. C.

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
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Lawes, C. M.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
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Lebreton-Decoster, C.

L. Frank, C. Lebreton-Decoster, G. Godeau, B. Coulomb, and J. Jozefonvicz, “Dextran derivatives modulate collagen matrix organization in dermal equivalent,” J. Biomater. Sci. Polym. Ed. 17(5), 499–517 (2006).
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Lecumberri, R.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
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Lee, C.

S. Park, C. Lee, J. Kim, and C. Kim, “Acoustic resolution photoacoustic microscopy,” Biomed. Eng. Lett. 4(3), 213–222 (2014).
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Lees, K. R.

Y. Yang, D. G. Grosset, Q. Li, A. Shuaib, and K. R. Lees, “Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model,” AJNR Am. J. Neuroradiol. 23(7), 1229–1236 (2002).
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Levine, R. L.

G. W. Tormoen, K. M. Haley, R. L. Levine, and O. J. T. McCarty, “Do circulating tumor cells play a role in coagulation and thrombosis?” Front. Oncol. 2, 115 (2012).
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Li, Q.

Y. Yang, D. G. Grosset, Q. Li, A. Shuaib, and K. R. Lees, “Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model,” AJNR Am. J. Neuroradiol. 23(7), 1229–1236 (2002).
[PubMed]

Lohse, C. M.

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Malinsky, T. I.

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

Mandala, M.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Marsh, J. D.

J. D. Marsh and S. G. Keyrouz, “Stroke prevention and treatment,” J. Am. Coll. Cardiol. 56(9), 683–691 (2010).
[Crossref] [PubMed]

Marty, M.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Maslov, K.

McCarty, O. J. T.

G. W. Tormoen, K. M. Haley, R. L. Levine, and O. J. T. McCarty, “Do circulating tumor cells play a role in coagulation and thrombosis?” Front. Oncol. 2, 115 (2012).
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R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
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Mehta, J. L.

E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
[Crossref] [PubMed]

Melerzanov, A. V.

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
[Crossref] [PubMed]

Melton, L. J.

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Menyaev, Y. A.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Y. A. Menyaev, K. A. Carey, D. A. Nedosekin, M. Sarimollaoglu, E. I. Galanzha, J. S. Stumhofer, and V. P. Zharov, “Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery,” Biomed. Opt. Express 7(9), 3643–3658 (2016).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

Y. A. Menyaev, D. A. Nedosekin, M. Sarimollaoglu, M. A. Juratli, E. I. Galanzha, V. V. Tuchin, and V. P. Zharov, “Optical clearing in photoacoustic flow cytometry,” Biomed. Opt. Express 4(12), 3030–3041 (2013).
[Crossref] [PubMed]

Merrill-Skoloff, G.

S. Falati, P. Gross, G. Merrill-Skoloff, B. C. Furie, and B. Furie, “Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse,” Nat. Med. 8(10), 1175–1180 (2002).
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Mohr, D. N.

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Monreal, M.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Moore, C.

C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
[Crossref] [PubMed]

Moore, C. L.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

Moothanchery, M.

M. Moothanchery and M. Pramanik, “Performance characterization of a switchable acoustic resolution and optical resolution photoacoustic microscopy system,” Sensors (Basel) 17(2), 357 (2017).
[Crossref] [PubMed]

Mousa, S. A.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Nedosekin, D.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Nedosekin, D. A.

Y. A. Menyaev, K. A. Carey, D. A. Nedosekin, M. Sarimollaoglu, E. I. Galanzha, J. S. Stumhofer, and V. P. Zharov, “Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery,” Biomed. Opt. Express 7(9), 3643–3658 (2016).
[Crossref] [PubMed]

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

Y. A. Menyaev, D. A. Nedosekin, M. Sarimollaoglu, M. A. Juratli, E. I. Galanzha, V. V. Tuchin, and V. P. Zharov, “Optical clearing in photoacoustic flow cytometry,” Biomed. Opt. Express 4(12), 3030–3041 (2013).
[Crossref] [PubMed]

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
[Crossref] [PubMed]

Noble, S.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

O’Fallon, W. M.

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Pabinger, I.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Page, C. P.

C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
[Crossref] [PubMed]

Parag, V.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Park, S.

S. Park, C. Lee, J. Kim, and C. Kim, “Acoustic resolution photoacoustic microscopy,” Biomed. Eng. Lett. 4(3), 213–222 (2014).
[Crossref]

Patwardhan, N. A.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

Petterson, T. M.

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Pitchford, S. C.

C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
[Crossref] [PubMed]

Pramanik, M.

M. Moothanchery and M. Pramanik, “Performance characterization of a switchable acoustic resolution and optical resolution photoacoustic microscopy system,” Sensors (Basel) 17(2), 357 (2017).
[Crossref] [PubMed]

Prandoni, P.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Prins, M. H.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Qari, M. H.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Quick, C. M.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Radomski, M. W.

P. Jurasz, D. Alonso-Escolano, and M. W. Radomski, “Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation,” Br. J. Pharmacol. 143(7), 819–826 (2004).
[Crossref] [PubMed]

Romano, P. S.

R. H. White, H. Zhou, and P. S. Romano, “Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures,” Thromb. Haemost. 90(3), 446–455 (2003).
[PubMed]

Rusch, N. J.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

Sarimollaoglu, M.

H. J. Jawad, M. Sarimollaoglu, A. S. Biris, and V. P. Zharov, “Dynamic blood flow phantom with negative and positive photoacoustic contrasts,” Biomed. Opt. Express 9(10), 4702–4713 (2018).
[Crossref]

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Y. A. Menyaev, K. A. Carey, D. A. Nedosekin, M. Sarimollaoglu, E. I. Galanzha, J. S. Stumhofer, and V. P. Zharov, “Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery,” Biomed. Opt. Express 7(9), 3643–3658 (2016).
[Crossref] [PubMed]

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

Y. A. Menyaev, D. A. Nedosekin, M. Sarimollaoglu, M. A. Juratli, E. I. Galanzha, V. V. Tuchin, and V. P. Zharov, “Optical clearing in photoacoustic flow cytometry,” Biomed. Opt. Express 4(12), 3030–3041 (2013).
[Crossref] [PubMed]

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
[Crossref] [PubMed]

Scheer, A. S.

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

Schulman, A. R.

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

Selby, R.

W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen, “Cardiovascular risk factors and venous thromboembolism: a meta-analysis,” Circulation 117(1), 93–102 (2008).
[Crossref] [PubMed]

Shuaib, A.

Y. Yang, D. G. Grosset, Q. Li, A. Shuaib, and K. R. Lees, “Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model,” AJNR Am. J. Neuroradiol. 23(7), 1229–1236 (2002).
[PubMed]

Siegel, E. R.

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

Silverstein, M. D.

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Smeltzer, M. S.

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

Streiff, M. B.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Stumhofer, J. S.

Suen, J. Y.

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

Syrigos, K.

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Tormoen, G. W.

G. W. Tormoen, K. M. Haley, R. L. Levine, and O. J. T. McCarty, “Do circulating tumor cells play a role in coagulation and thrombosis?” Front. Oncol. 2, 115 (2012).
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T. Tsuruo, “Platelet aggregation in the formation of tumor metastasis,” Proc. of the Japan Academy 84, 189–198 (2008).

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Tuorto, S.

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
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C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
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Viegas, M. G.

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
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Wahl, D.

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
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Wang, L. V.

Wheeler, H. B.

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

White, R. H.

R. H. White, H. Zhou, and P. S. Romano, “Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures,” Thromb. Haemost. 90(3), 446–455 (2003).
[PubMed]

Xing, W.

Yang, Y.

Y. Yang, D. G. Grosset, Q. Li, A. Shuaib, and K. R. Lees, “Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model,” AJNR Am. J. Neuroradiol. 23(7), 1229–1236 (2002).
[PubMed]

Zharov, V.

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
[Crossref] [PubMed]

Zharov, V. P.

H. J. Jawad, M. Sarimollaoglu, A. S. Biris, and V. P. Zharov, “Dynamic blood flow phantom with negative and positive photoacoustic contrasts,” Biomed. Opt. Express 9(10), 4702–4713 (2018).
[Crossref]

Y. A. Menyaev, K. A. Carey, D. A. Nedosekin, M. Sarimollaoglu, E. I. Galanzha, J. S. Stumhofer, and V. P. Zharov, “Preclinical photoacoustic models: application for ultrasensitive single cell malaria diagnosis in large vein and artery,” Biomed. Opt. Express 7(9), 3643–3658 (2016).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
[Crossref] [PubMed]

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
[Crossref] [PubMed]

Y. A. Menyaev, D. A. Nedosekin, M. Sarimollaoglu, M. A. Juratli, E. I. Galanzha, V. V. Tuchin, and V. P. Zharov, “Optical clearing in photoacoustic flow cytometry,” Biomed. Opt. Express 4(12), 3030–3041 (2013).
[Crossref] [PubMed]

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
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E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
[Crossref] [PubMed]

Zhou, H.

R. H. White, H. Zhou, and P. S. Romano, “Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures,” Thromb. Haemost. 90(3), 446–455 (2003).
[PubMed]

AACN Adv. Crit. Care (1)

D. K. Dressler, “Death by clot: acute coronary syndromes, ischemic stroke, pulmonary embolism, and disseminated intravascular coagulation,” AACN Adv. Crit. Care 20(2), 166–176 (2009).
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Acta Pharmacol. Sin. (1)

J. G. Geng, “Interaction of vascular endothelial cells with leukocytes, platelets and cancer cells in inflammation, thrombosis and cancer growth and metastasis,” Acta Pharmacol. Sin. 24(12), 1297–1300 (2003).
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AJNR Am. J. Neuroradiol. (1)

Y. Yang, D. G. Grosset, Q. Li, A. Shuaib, and K. R. Lees, “Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model,” AJNR Am. J. Neuroradiol. 23(7), 1229–1236 (2002).
[PubMed]

Ann. Surg. (1)

R. A. Auer, A. S. Scheer, J. I. McSparron, A. R. Schulman, S. Tuorto, S. Doucette, J. Gonsalves, and Y. Fong, “Postoperative venous thromboembolism predicts survival in cancer patients,” Ann. Surg. 255(5), 963–970 (2012).
[Crossref] [PubMed]

Arch. Intern. Med. (2)

F. A. Anderson, H. B. Wheeler, R. J. Goldberg, D. W. Hosmer, N. A. Patwardhan, B. Jovanovic, A. Forcier, and J. E. Dalen, “A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study,” Arch. Intern. Med. 151(5), 933–938 (1991).
[Crossref] [PubMed]

J. A. Heit, W. M. O’Fallon, T. M. Petterson, C. M. Lohse, M. D. Silverstein, D. N. Mohr, and L. J. Melton, “Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study,” Arch. Intern. Med. 162(11), 1245–1248 (2002).
[Crossref] [PubMed]

Biochem. Biophys. Res. Commun. (1)

N. A. Koonce, M. A. Juratli, C. Cai, M. Sarimollaoglu, Y. A. Menyaev, J. Dent, C. M. Quick, R. P. M. Dings, D. Nedosekin, V. Zharov, and R. J. Griffin, “Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry,” Biochem. Biophys. Res. Commun. 492(3), 507–512 (2017).
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Biomed. Eng. Lett. (1)

S. Park, C. Lee, J. Kim, and C. Kim, “Acoustic resolution photoacoustic microscopy,” Biomed. Eng. Lett. 4(3), 213–222 (2014).
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Biomed. Opt. Express (3)

Br. J. Pharmacol. (1)

P. Jurasz, D. Alonso-Escolano, and M. W. Radomski, “Platelet--cancer interactions: mechanisms and pharmacology of tumour cell-induced platelet aggregation,” Br. J. Pharmacol. 143(7), 819–826 (2004).
[Crossref] [PubMed]

Cancers (Basel) (1)

M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, A. V. Melerzanov, V. P. Zharov, and E. I. Galanzha, “Dynamic fluctuation of circulating tumor cells during cancer progression,” Cancers (Basel) 6(1), 128–142 (2014).
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Circulation (2)

J. C. Grotta and A. V. Alexandrov, “Preventing stroke: is preventing microemboli enough?” Circulation 103(19), 2321–2322 (2001).
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W. Ageno, C. Becattini, T. Brighton, R. Selby, and P. W. Kamphuisen, “Cardiovascular risk factors and venous thromboembolism: a meta-analysis,” Circulation 117(1), 93–102 (2008).
[Crossref] [PubMed]

Cytometry A (1)

E. I. Galanzha, M. Sarimollaoglu, D. A. Nedosekin, S. G. Keyrouz, J. L. Mehta, and V. P. Zharov, “In vivo flow cytometry of circulating clots using negative photothermal and photoacoustic contrasts,” Cytometry A 79A(10), 814–824 (2011).
[Crossref] [PubMed]

Front. Oncol. (1)

G. W. Tormoen, K. M. Haley, R. L. Levine, and O. J. T. McCarty, “Do circulating tumor cells play a role in coagulation and thrombosis?” Front. Oncol. 2, 115 (2012).
[Crossref] [PubMed]

Head Neck (1)

M. A. Juratli, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, E. I. Galanzha, J. Y. Suen, and V. P. Zharov, “Real-time monitoring of circulating tumor cell release during tumor manipulation using in vivo photoacoustic and fluorescent flow cytometry,” Head Neck 36(8), 1207–1215 (2014).
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Hematology (Am. Soc. Hematol. Educ. Program) (1)

A. A. Khorana, “Cancer-associated thrombosis: updates and controversies,” Hematology (Am. Soc. Hematol. Educ. Program) 2012, 626–630 (2012).
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Hosp Pract (1995) (1)

A. Deng, T. Galanis, and M. G. Graham, “Venous thromboembolism in cancer patients,” Hosp Pract (1995) 42(5), 24–33 (2014).
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J. Am. Coll. Cardiol. (1)

J. D. Marsh and S. G. Keyrouz, “Stroke prevention and treatment,” J. Am. Coll. Cardiol. 56(9), 683–691 (2010).
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J. Biomater. Sci. Polym. Ed. (1)

L. Frank, C. Lebreton-Decoster, G. Godeau, B. Coulomb, and J. Jozefonvicz, “Dextran derivatives modulate collagen matrix organization in dermal equivalent,” J. Biomater. Sci. Polym. Ed. 17(5), 499–517 (2006).
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J. Biophotonics (1)

D. A. Nedosekin, M. A. Juratli, M. Sarimollaoglu, C. L. Moore, N. J. Rusch, M. S. Smeltzer, V. P. Zharov, and E. I. Galanzha, “Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo,” J. Biophotonics 6(6-7), 523–533 (2013).
[Crossref] [PubMed]

J. Thromb. Haemost. (1)

D. Farge, P. Debourdeau, M. Beckers, C. Baglin, R. M. Bauersachs, B. Brenner, D. Brilhante, A. Falanga, G. T. Gerotzafias, N. Haim, A. K. Kakkar, A. A. Khorana, R. Lecumberri, M. Mandala, M. Marty, M. Monreal, S. A. Mousa, S. Noble, I. Pabinger, P. Prandoni, M. H. Prins, M. H. Qari, M. B. Streiff, K. Syrigos, H. Bounameaux, and H. R. Büller, “International clinical practice guidelines for the treatment and prophylaxis of venous thromboembolism in patients with cancer,” J. Thromb. Haemost. 11(1), 56–70 (2013).
[Crossref] [PubMed]

Lancet Neurol. (1)

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Methods (1)

E. I. Galanzha and V. P. Zharov, “Photoacoustic flow cytometry,” Methods 57(3), 280–296 (2012).
[Crossref] [PubMed]

Nat. Med. (1)

S. Falati, P. Gross, G. Merrill-Skoloff, B. C. Furie, and B. Furie, “Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse,” Nat. Med. 8(10), 1175–1180 (2002).
[Crossref] [PubMed]

Opt. Lett. (1)

PLoS One (2)

M. A. Juratli, E. R. Siegel, D. A. Nedosekin, M. Sarimollaoglu, A. Jamshidi-Parsian, C. Cai, Y. A. Menyaev, J. Y. Suen, E. I. Galanzha, and V. P. Zharov, “In vivo long-term monitoring of circulating tumor cells fluctuation during medical interventions,” PLoS One 10(9), e0137613 (2015).
[Crossref] [PubMed]

M. A. Juratli, Y. A. Menyaev, M. Sarimollaoglu, E. R. Siegel, D. A. Nedosekin, J. Y. Suen, A. V. Melerzanov, T. A. Juratli, E. I. Galanzha, and V. P. Zharov, “Real-time label-free embolus detection using in vivo photoacoustic flow cytometry,” PLoS One 11(5), e0156269 (2016).
[Crossref] [PubMed]

Proc. of the Japan Academy (1)

T. Tsuruo, “Platelet aggregation in the formation of tumor metastasis,” Proc. of the Japan Academy 84, 189–198 (2008).

Sci. Rep. (1)

E. I. Galanzha, M. G. Viegas, T. I. Malinsky, A. V. Melerzanov, M. A. Juratli, M. Sarimollaoglu, D. A. Nedosekin, and V. P. Zharov, “In vivo acoustic and photoacoustic focusing of circulating cells,” Sci. Rep. 6(1), 21531 (2016).
[Crossref] [PubMed]

Sensors (Basel) (1)

M. Moothanchery and M. Pramanik, “Performance characterization of a switchable acoustic resolution and optical resolution photoacoustic microscopy system,” Sensors (Basel) 17(2), 357 (2017).
[Crossref] [PubMed]

Stud. Health Technol. Inform. (1)

R. Gerrah and O. David, “In vivo quantification of clot formation in extracorporeal circuits,” Stud. Health Technol. Inform. 184, 148–150 (2013).
[PubMed]

Thromb. Haemost. (3)

C. Tymvios, S. Jones, C. Moore, S. C. Pitchford, C. P. Page, and M. Emerson, “Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse,” Thromb. Haemost. 99(2), 435–440 (2008).
[Crossref] [PubMed]

R. H. White, H. Zhou, and P. S. Romano, “Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures,” Thromb. Haemost. 90(3), 446–455 (2003).
[PubMed]

A. Blum, A. Bellou, F. Guillemin, P. Douek, M. C. Laprévote-Heully, D. Wahl, and GENEPI study group, “Performance of magnetic resonance angiography in suspected acute pulmonary embolism,” Thromb. Haemost. 93(3), 503–511 (2005).
[Crossref] [PubMed]

Other (1)

M. A. Juratli, D. A. Nedosekin, M. Sarimollaoglu, E. R. Siegel, E. I. Galanzha, and V. P. Zharov, “Circulating tumor cells as predictive marker in metastatic disease,” in Perioperative Inflammation as Triggering Origin of Metastasis Development (Springer, 2017), pp. 109–122.

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Figures (5)

Fig. 1
Fig. 1 The principle of PA detection of red, white and mixed CBCs producing positive, negative and combined PA contrast peaks in blood background, respectively. (a) Schematic of acoustic resolution PAFC diagnostic platform using a high pulse-repetition-rate laser and focused ultrasound transducer with a central hole to deliver laser light through a fiber. (b) PA trace showing PA peaks with positive (red CBC), negative (white CBC) and combined (mixed CBCs) contrast in the blood background.
Fig. 2
Fig. 2 Photos of animal model fragments and experimental schematics. (a) Picture of a rat tail during needle insertion. The PA probe was located on the same tail vein. (b) Picture of a rat neck after shaving the skin. The PA probe was located on the carotid artery. (c) Picture of the rabbit’s right ear. (d) Pictures of the in vivo PAFC setup in a rabbit model. The PA probe was located on the femoral vein after shaving the skin.
Fig. 3
Fig. 3 (a) Example of PA trace from a carotid artery of rat in control group. Example of formation of red, white and mixed CBCs after vessel wall damage through needle insertion in tail vein (b) and carotid artery (c).
Fig. 4
Fig. 4 Examples of PA traces from the vessels in rats after collagen (a) and Dextran 500 (b) injection. (c) Comparison of PA peak amplitude fluctuations of positive (red) and negative (blue) contrast for three rats.
Fig. 5
Fig. 5 Examples of PA traces in the rat model after transparent bead injection in rat tail vein and PA monitoring in tail vein (a) and carotid artery (b). Examples of PA traces in the rabbit model after catheter insertion (c), injection of transparent spheres (d) and microbubbles injections (e).

Tables (1)

Tables Icon

Table 1 The parameters of blood vessels tested with PAFC

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