Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) has become a popular tool in small-animal hemodynamic studies. However, previous OR-PAM techniques variously lacked a high imaging speed and/or a large field of view, impeding the study of highly dynamic physiologic and pathophysiologic processes over a large region of interest. Here we report a high-speed OR-PAM system with an ultra-wide field of view, enabled by an innovative water-immersible hexagon-mirror scanner. By driving the hexagon-mirror scanner with a high-precision DC motor, the new OR-PAM has achieved a cross-sectional frame rate of 900 Hz over a 12-mm scanning range, which is 3900 times faster than our previous motor-scanner-based system and 10 times faster than the MEMS-scanner-based system. Using this hexagon-scanner-based OR-PAM system, we have imaged epinephrine-induced vasoconstriction in the whole mouse ear and vascular reperfusion after ischemic stroke in the mouse cortex in vivo, with a high spatial resolution and high volumetric imaging speed. We expect that the hexagon-scanner-based OR-PAM system will become a powerful tool for small animal imaging where the hemodynamic responses over a large field of view are of interest.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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    [Crossref] [PubMed]

2018 (1)

2017 (3)

T. Jin, H. Guo, H. Jiang, B. Ke, and L. Xi, “Portable optical resolution photoacoustic microscopy (pORPAM) for human oral imaging,” Opt. Lett. 42(21), 4434–4437 (2017).
[Crossref] [PubMed]

Y. C. Wang, E. H. Sanchez-Mendoza, T. R. Doeppner, and D. M. Hermann, “Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity,” J. Cereb. Blood Flow Metab. 37(3), 980–993 (2017).
[Crossref] [PubMed]

M. Jiang, S. Yu, Z. Yu, H. Sheng, Y. Li, S. Liu, D. S. Warner, W. Paschen, and W. Yang, “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G,” Stroke 48(6), 1646–1654 (2017).
[Crossref] [PubMed]

2016 (4)

J. Y. Kim, C. Lee, K. Park, S. Han, and C. Kim, “High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid,” Sci Rep. 6, 34803 (2016)

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
[Crossref] [PubMed]

F. Gao, X. H. Feng, and Y. J. Zheng, “Advanced photoacoustic and thermoacoustic sensing and imaging beyond pulsed absorption contrast,” J. Opt. 18(7), 074006 (2016).
[Crossref]

H. He, G. Wissmeyer, S. V. Ovsepian, A. Buehler, and V. Ntziachristos, “Hybrid optical and acoustic resolution optoacoustic endoscopy,” Opt. Lett. 41(12), 2708–2710 (2016).
[Crossref] [PubMed]

2015 (2)

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. W. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, “High-speed label-free functional photoacoustic microscopy of mouse brain in action,” Nat. Methods 12(5), 407–410 (2015).
[Crossref] [PubMed]

J. Y. Kim, C. Lee, K. Park, G. Lim, and C. Kim, “Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner,” Sci Rep. 5, 7932 (2015).

2014 (5)

R. L. Shelton, S. P. Mattison, and B. E. Applegate, “Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy,” J. Biophoton. 7(10), 834–840 (2014).
[Crossref] [PubMed]

H. Estrada, J. Turner, M. Kneipp, and D. Razansky, “Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution,” Laser Phys. Lett. 11(4), 045601 (2014).
[Crossref]

J. Yao and L. V. Wang, “Sensitivity of photoacoustic microscopy,” Photoacoustics 2(2), 87–101 (2014).
[Crossref] [PubMed]

G. J. Tserevelakis, D. Soliman, M. Omar, and V. Ntziachristos, “Hybrid multiphoton and optoacoustic microscope,” Opt. Lett. 39(7), 1819–1822 (2014).
[Crossref] [PubMed]

D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
[Crossref] [PubMed]

2013 (2)

N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
[Crossref] [PubMed]

J. Yao and L. V. Wang, “Photoacoustic microscopy,” Laser Photonics Rev. 7(5), 758–778 (2013).
[Crossref] [PubMed]

2012 (3)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

R. Ma, S. Söntges, S. Shoham, V. Ntziachristos, and D. Razansky, “Fast scanning coaxial optoacoustic microscopy,” Biomed. Opt. Express 3(7), 1724–1731 (2012).
[Crossref] [PubMed]

J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
[Crossref] [PubMed]

2011 (4)

2010 (2)

2009 (6)

2008 (4)

M. Shoroghi, S. H. Sadrolsadat, M. Razzaghi, F. Farahbakhsh, M. Sheikhvatan, M. Sheikhfathollahi, and A. Abbasi, “Effect of different epinephrine concentrations on local bleeding and hemodynamics during dermatologic surgery,” Acta Dermatovenerol. Croat. 16(4), 209–214 (2008).
[PubMed]

K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008).
[Crossref] [PubMed]

K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33(9), 929–931 (2008).
[Crossref] [PubMed]

S. F. Kemp, R. F. Lockey, F. E. Simons, and World Allergy Organization ad hoc Committee on Epinephrine in Anaphylaxis, “Epinephrine: the drug of choice for anaphylaxis-a statement of the world allergy organization,” World Allergy Organ. J. 1(7), S18–S26 (2008).
[PubMed]

2007 (2)

O. Baranova, L. F. Miranda, P. Pichiule, I. Dragatsis, R. S. Johnson, and J. C. Chavez, “Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia,” J. Neurosci. 27(23), 6320–6332 (2007).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. H. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90, 053901 (2007).

2005 (1)

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
[Crossref] [PubMed]

2004 (1)

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
[Crossref] [PubMed]

1988 (1)

J. S. Floras, P. E. Aylward, R. G. Victor, A. L. Mark, and F. M. Abboud, “Epinephrine facilitates neurogenic vasoconstriction in humans,” J. Clin. Invest. 81(4), 1265–1274 (1988).
[Crossref] [PubMed]

1985 (1)

A. Colantuoni, S. Bertuglia, and M. Intaglietta, “Variations of Rhythmic Diameter Changes at the Arterial Microvascular Bifurcations,” Pflugers Arch. 403(3), 289–295 (1985).
[Crossref] [PubMed]

1977 (1)

A. J. Jerri, “Shannon sampling theorem - its various extensions and applications - tutorial review,” Proc. IEEE 65(11), 1565–1596 (1977).
[Crossref]

1972 (1)

A. C. Yard and P. J. Kadowitz, “Studies on the mechanism of hydrocortisone potentiation of vasoconstrictor responses to epinephrine in the anesthetized animal,” Eur. J. Pharmacol. 20(1), 1–9 (1972).
[Crossref] [PubMed]

Abbasi, A.

M. Shoroghi, S. H. Sadrolsadat, M. Razzaghi, F. Farahbakhsh, M. Sheikhvatan, M. Sheikhfathollahi, and A. Abbasi, “Effect of different epinephrine concentrations on local bleeding and hemodynamics during dermatologic surgery,” Acta Dermatovenerol. Croat. 16(4), 209–214 (2008).
[PubMed]

Abboud, F. M.

J. S. Floras, P. E. Aylward, R. G. Victor, A. L. Mark, and F. M. Abboud, “Epinephrine facilitates neurogenic vasoconstriction in humans,” J. Clin. Invest. 81(4), 1265–1274 (1988).
[Crossref] [PubMed]

Agalliu, D.

D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
[Crossref] [PubMed]

Applegate, B. E.

R. L. Shelton, S. P. Mattison, and B. E. Applegate, “Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy,” J. Biophoton. 7(10), 834–840 (2014).
[Crossref] [PubMed]

Arac, A.

D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
[Crossref] [PubMed]

Aylward, P. E.

J. S. Floras, P. E. Aylward, R. G. Victor, A. L. Mark, and F. M. Abboud, “Epinephrine facilitates neurogenic vasoconstriction in humans,” J. Clin. Invest. 81(4), 1265–1274 (1988).
[Crossref] [PubMed]

Azouvi, P.

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
[Crossref] [PubMed]

Baranova, O.

O. Baranova, L. F. Miranda, P. Pichiule, I. Dragatsis, R. S. Johnson, and J. C. Chavez, “Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia,” J. Neurosci. 27(23), 6320–6332 (2007).
[Crossref] [PubMed]

Barres, B. A.

D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
[Crossref] [PubMed]

Bartolomeo, P.

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
[Crossref] [PubMed]

Beard, P.

Beard, P. C.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[Crossref] [PubMed]

Bednar, B.

N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
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A. Colantuoni, S. Bertuglia, and M. Intaglietta, “Variations of Rhythmic Diameter Changes at the Arterial Microvascular Bifurcations,” Pflugers Arch. 403(3), 289–295 (1985).
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N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
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A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
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J. S. Floras, P. E. Aylward, R. G. Victor, A. L. Mark, and F. M. Abboud, “Epinephrine facilitates neurogenic vasoconstriction in humans,” J. Clin. Invest. 81(4), 1265–1274 (1988).
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Gao, F.

F. Gao, X. H. Feng, and Y. J. Zheng, “Advanced photoacoustic and thermoacoustic sensing and imaging beyond pulsed absorption contrast,” J. Opt. 18(7), 074006 (2016).
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Hajireza, P.

Han, S.

J. Y. Kim, C. Lee, K. Park, S. Han, and C. Kim, “High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid,” Sci Rep. 6, 34803 (2016)

He, H.

Herlitz, J.

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
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Y. C. Wang, E. H. Sanchez-Mendoza, T. R. Doeppner, and D. M. Hermann, “Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity,” J. Cereb. Blood Flow Metab. 37(3), 980–993 (2017).
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Hollenberg, J.

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
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J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
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A. Colantuoni, S. Bertuglia, and M. Intaglietta, “Variations of Rhythmic Diameter Changes at the Arterial Microvascular Bifurcations,” Pflugers Arch. 403(3), 289–295 (1985).
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N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
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Jiang, M.

M. Jiang, S. Yu, Z. Yu, H. Sheng, Y. Li, S. Liu, D. S. Warner, W. Paschen, and W. Yang, “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G,” Stroke 48(6), 1646–1654 (2017).
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Jin, T.

Johnson, R. S.

O. Baranova, L. F. Miranda, P. Pichiule, I. Dragatsis, R. S. Johnson, and J. C. Chavez, “Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia,” J. Neurosci. 27(23), 6320–6332 (2007).
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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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J. Y. Kim, C. Lee, K. Park, S. Han, and C. Kim, “High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid,” Sci Rep. 6, 34803 (2016)

J. Y. Kim, C. Lee, K. Park, G. Lim, and C. Kim, “Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner,” Sci Rep. 5, 7932 (2015).

Kim, J. Y.

J. Y. Kim, C. Lee, K. Park, S. Han, and C. Kim, “High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid,” Sci Rep. 6, 34803 (2016)

J. Y. Kim, C. Lee, K. Park, G. Lim, and C. Kim, “Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner,” Sci Rep. 5, 7932 (2015).

Kneipp, M.

H. Estrada, J. Turner, M. Kneipp, and D. Razansky, “Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution,” Laser Phys. Lett. 11(4), 045601 (2014).
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D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
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Laufer, J. G.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
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Leclercq, M.

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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Lee, C.

J. Y. Kim, C. Lee, K. Park, S. Han, and C. Kim, “High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid,” Sci Rep. 6, 34803 (2016)

J. Y. Kim, C. Lee, K. Park, G. Lim, and C. Kim, “Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner,” Sci Rep. 5, 7932 (2015).

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J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. W. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, “High-speed label-free functional photoacoustic microscopy of mouse brain in action,” Nat. Methods 12(5), 407–410 (2015).
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M. Jiang, S. Yu, Z. Yu, H. Sheng, Y. Li, S. Liu, D. S. Warner, W. Paschen, and W. Yang, “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G,” Stroke 48(6), 1646–1654 (2017).
[Crossref] [PubMed]

Lim, G.

J. Y. Kim, C. Lee, K. Park, G. Lim, and C. Kim, “Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner,” Sci Rep. 5, 7932 (2015).

Liu, S.

M. Jiang, S. Yu, Z. Yu, H. Sheng, Y. Li, S. Liu, D. S. Warner, W. Paschen, and W. Yang, “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G,” Stroke 48(6), 1646–1654 (2017).
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Lockey, R. F.

S. F. Kemp, R. F. Lockey, F. E. Simons, and World Allergy Organization ad hoc Committee on Epinephrine in Anaphylaxis, “Epinephrine: the drug of choice for anaphylaxis-a statement of the world allergy organization,” World Allergy Organ. J. 1(7), S18–S26 (2008).
[PubMed]

Louis-Dreyfus, A.

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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Lundgren, P.

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
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Lundin, A.

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
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D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
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Marchal, F.

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
[Crossref] [PubMed]

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J. S. Floras, P. E. Aylward, R. G. Victor, A. L. Mark, and F. M. Abboud, “Epinephrine facilitates neurogenic vasoconstriction in humans,” J. Clin. Invest. 81(4), 1265–1274 (1988).
[Crossref] [PubMed]

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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
[Crossref] [PubMed]

Maslov, K.

Maslov, K. I.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. W. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, “High-speed label-free functional photoacoustic microscopy of mouse brain in action,” Nat. Methods 12(5), 407–410 (2015).
[Crossref] [PubMed]

J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
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R. L. Shelton, S. P. Mattison, and B. E. Applegate, “Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy,” J. Biophoton. 7(10), 834–840 (2014).
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O. Baranova, L. F. Miranda, P. Pichiule, I. Dragatsis, R. S. Johnson, and J. C. Chavez, “Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia,” J. Neurosci. 27(23), 6320–6332 (2007).
[Crossref] [PubMed]

Morin, N.

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
[Crossref] [PubMed]

Morscher, S.

N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
[Crossref] [PubMed]

Nimmerjahn, A.

D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
[Crossref] [PubMed]

Nordberg, P.

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
[Crossref] [PubMed]

Ntziachristos, V.

Omar, M.

Ovsepian, S. V.

Park, K.

J. Y. Kim, C. Lee, K. Park, S. Han, and C. Kim, “High-speed and high-SNR photoacoustic microscopy based on a galvanometer mirror in non-conducting liquid,” Sci Rep. 6, 34803 (2016)

J. Y. Kim, C. Lee, K. Park, G. Lim, and C. Kim, “Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner,” Sci Rep. 5, 7932 (2015).

Paschen, W.

M. Jiang, S. Yu, Z. Yu, H. Sheng, Y. Li, S. Liu, D. S. Warner, W. Paschen, and W. Yang, “XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G,” Stroke 48(6), 1646–1654 (2017).
[Crossref] [PubMed]

Patel, M.

N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
[Crossref] [PubMed]

Pedley, R. B.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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Puliafito, C. A.

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A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
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Razansky, D.

H. Estrada, J. Turner, M. Kneipp, and D. Razansky, “Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution,” Laser Phys. Lett. 11(4), 045601 (2014).
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N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
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R. Ma, S. Söntges, S. Shoham, V. Ntziachristos, and D. Razansky, “Fast scanning coaxial optoacoustic microscopy,” Biomed. Opt. Express 3(7), 1724–1731 (2012).
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A. Buehler, E. Herzog, D. Razansky, and V. Ntziachristos, “Video rate optoacoustic tomography of mouse kidney perfusion,” Opt. Lett. 35(14), 2475–2477 (2010).
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R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009).
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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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M. Shoroghi, S. H. Sadrolsadat, M. Razzaghi, F. Farahbakhsh, M. Sheikhvatan, M. Sheikhfathollahi, and A. Abbasi, “Effect of different epinephrine concentrations on local bleeding and hemodynamics during dermatologic surgery,” Acta Dermatovenerol. Croat. 16(4), 209–214 (2008).
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Y. C. Wang, E. H. Sanchez-Mendoza, T. R. Doeppner, and D. M. Hermann, “Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity,” J. Cereb. Blood Flow Metab. 37(3), 980–993 (2017).
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Shao, P.

Sheikhfathollahi, M.

M. Shoroghi, S. H. Sadrolsadat, M. Razzaghi, F. Farahbakhsh, M. Sheikhvatan, M. Sheikhfathollahi, and A. Abbasi, “Effect of different epinephrine concentrations on local bleeding and hemodynamics during dermatologic surgery,” Acta Dermatovenerol. Croat. 16(4), 209–214 (2008).
[PubMed]

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M. Shoroghi, S. H. Sadrolsadat, M. Razzaghi, F. Farahbakhsh, M. Sheikhvatan, M. Sheikhfathollahi, and A. Abbasi, “Effect of different epinephrine concentrations on local bleeding and hemodynamics during dermatologic surgery,” Acta Dermatovenerol. Croat. 16(4), 209–214 (2008).
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Shi, W.

Shoham, S.

Shoroghi, M.

M. Shoroghi, S. H. Sadrolsadat, M. Razzaghi, F. Farahbakhsh, M. Sheikhvatan, M. Sheikhfathollahi, and A. Abbasi, “Effect of different epinephrine concentrations on local bleeding and hemodynamics during dermatologic surgery,” Acta Dermatovenerol. Croat. 16(4), 209–214 (2008).
[PubMed]

Shung, K. K.

Sieroff, E.

J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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Soliman, D.

Söntges, S.

Steinberg, G. K.

D. Knowland, A. Arac, K. J. Sekiguchi, M. Hsu, S. E. Lutz, J. Perrino, G. K. Steinberg, B. A. Barres, A. Nimmerjahn, and D. Agalliu, “Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke,” Neuron 82(3), 603–617 (2014).
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Stoica, G.

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. H. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90, 053901 (2007).

Svensson, L.

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
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Taruttis, A.

N. C. Burton, M. Patel, S. Morscher, W. H. Driessen, J. Claussen, N. Beziere, T. Jetzfellner, A. Taruttis, D. Razansky, B. Bednar, and V. Ntziachristos, “Multispectral opto-acoustic tomography (MSOT) of the brain and glioblastoma characterization,” Neuroimage 65, 522–528 (2013).
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R. Ma, A. Taruttis, V. Ntziachristos, and D. Razansky, “Multispectral optoacoustic tomography (MSOT) scanner for whole-body small animal imaging,” Opt. Express 17(24), 21414–21426 (2009).
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Turner, J.

H. Estrada, J. Turner, M. Kneipp, and D. Razansky, “Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution,” Laser Phys. Lett. 11(4), 045601 (2014).
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J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
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L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett. 36(2), 139–141 (2011).
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B. Rao, L. Li, K. Maslov, and L. Wang, “Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging,” Opt. Lett. 35(10), 1521–1523 (2010).
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H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. H. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90, 053901 (2007).

Wang, L. V.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. W. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, “High-speed label-free functional photoacoustic microscopy of mouse brain in action,” Nat. Methods 12(5), 407–410 (2015).
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J. Yao and L. V. Wang, “Sensitivity of photoacoustic microscopy,” Photoacoustics 2(2), 87–101 (2014).
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J. Yao and L. V. Wang, “Photoacoustic microscopy,” Laser Photonics Rev. 7(5), 758–778 (2013).
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J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
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L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett. 36(2), 139–141 (2011).
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B. Rao, K. Maslov, A. Danielli, R. Chen, K. K. Shung, Q. Zhou, and L. V. Wang, “Real-time four-dimensional optical-resolution photoacoustic microscopy with Au nanoparticle-assisted subdiffraction-limit resolution,” Opt. Lett. 36(7), 1137–1139 (2011).
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C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
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V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
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Wang, Y. C.

Y. C. Wang, E. H. Sanchez-Mendoza, T. R. Doeppner, and D. M. Hermann, “Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity,” J. Cereb. Blood Flow Metab. 37(3), 980–993 (2017).
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Warner, D. S.

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Weissleder, R.

V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, “Looking and listening to light: the evolution of whole-body photonic imaging,” Nat. Biotechnol. 23(3), 313–320 (2005).
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J. M. Beis, C. Keller, N. Morin, P. Bartolomeo, T. Bernati, S. Chokron, M. Leclercq, A. Louis-Dreyfus, F. Marchal, Y. Martin, D. Perennou, P. Pradat-Diehl, C. Prairial, G. Rode, M. Rousseaux, C. Samuel, E. Sieroff, L. Wiart, P. Azouvi, and French Collaborative Study Group on Assessment of Unilateral Neglect (GEREN/GRECO), “Right spatial neglect after left hemisphere stroke: qualitative and quantitative study,” Neurology 63(9), 1600–1605 (2004).
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Wong, T. T. W.

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Xie, Z.

Yang, J. M.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. W. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, “High-speed label-free functional photoacoustic microscopy of mouse brain in action,” Nat. Methods 12(5), 407–410 (2015).
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J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
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Yang, W.

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Yao, J.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. W. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, “High-speed label-free functional photoacoustic microscopy of mouse brain in action,” Nat. Methods 12(5), 407–410 (2015).
[Crossref] [PubMed]

J. Yao and L. V. Wang, “Sensitivity of photoacoustic microscopy,” Photoacoustics 2(2), 87–101 (2014).
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J. Yao and L. V. Wang, “Photoacoustic microscopy,” Laser Photonics Rev. 7(5), 758–778 (2013).
[Crossref] [PubMed]

J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
[Crossref] [PubMed]

L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett. 36(2), 139–141 (2011).
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Yard, A. C.

A. C. Yard and P. J. Kadowitz, “Studies on the mechanism of hydrocortisone potentiation of vasoconstrictor responses to epinephrine in the anesthetized animal,” Eur. J. Pharmacol. 20(1), 1–9 (1972).
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Yu, Z.

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Zhang, E.

Zhang, E. Z.

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Zhou, Q.

Zou, J.

J. Yao, L. Wang, J. M. Yang, K. I. Maslov, T. T. W. Wong, L. Li, C. H. Huang, J. Zou, and L. V. Wang, “High-speed label-free functional photoacoustic microscopy of mouse brain in action,” Nat. Methods 12(5), 407–410 (2015).
[Crossref] [PubMed]

J. Yao, C. H. Huang, L. Wang, J. M. Yang, L. Gao, K. I. Maslov, J. Zou, and L. V. Wang, “Wide-field fast-scanning photoacoustic microscopy based on a water-immersible MEMS scanning mirror,” J. Biomed. Opt. 17(8), 080505 (2012).
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Acta Dermatovenerol. Croat. (1)

M. Shoroghi, S. H. Sadrolsadat, M. Razzaghi, F. Farahbakhsh, M. Sheikhvatan, M. Sheikhfathollahi, and A. Abbasi, “Effect of different epinephrine concentrations on local bleeding and hemodynamics during dermatologic surgery,” Acta Dermatovenerol. Croat. 16(4), 209–214 (2008).
[PubMed]

Appl. Opt. (2)

Appl. Phys. Lett. (1)

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. H. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90, 053901 (2007).

Biomed. Opt. Express (1)

Eur. Heart J. Cardiovasc. Pharmacother. (1)

A. Lundin, T. Djärv, J. Engdahl, J. Hollenberg, P. Nordberg, A. Ravn-Fischer, M. Ringh, S. Rysz, L. Svensson, J. Herlitz, and P. Lundgren, “Drug therapy in cardiac arrest: a review of the literature,” Eur. Heart J. Cardiovasc. Pharmacother. 2(1), 54–75 (2016).
[Crossref] [PubMed]

Eur. J. Pharmacol. (1)

A. C. Yard and P. J. Kadowitz, “Studies on the mechanism of hydrocortisone potentiation of vasoconstrictor responses to epinephrine in the anesthetized animal,” Eur. J. Pharmacol. 20(1), 1–9 (1972).
[Crossref] [PubMed]

J. Biomed. Opt. (1)

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Supplementary Material (3)

NameDescription
» Visualization 1       The hexagon-mirror scanner steers both the excitation light and emission sound waves under water, with a 900-Hz B-scan rate and 12-mm scanning range.
» Visualization 2       HM-OR-PAM of the vasoconstriction dynamics in a mouse ear after the injection of epinephrine, showing the reduction of blood perfusion in small vessels.
» Visualization 3       HM-OR-PAM of the vascular reperfusion in a mouse brain after ischemic stroke, showing the spatially heterogenous reperfusion magnitude and responding time. The signal increase (shown in color) is superimposed on the baseline image before the ischemic

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Figures (8)

Fig. 1
Fig. 1 Hexagon-mirror based optical-resolution photoacoustic microscopy (HM-OR-PAM). (a) Schematic of the HM-OR-PAM system. AC, aluminum coating; HM, hexagon mirror; UST, ultrasonic transducer. (b) 3D drawing and (c) photograph of the hexagon scanning mirror driven by a high-speed DC-motor.
Fig. 2
Fig. 2 The scanning characteristics of the hexagon-mirror scanner. (a) The revolution rate and the scanning range of the hexagon-mirror scanner as a function of the driving voltage applied to the DC motor. (b) Schematic of the usable scanning zone (yellow) and unusable zone outside the detection region of the ultrasonic transducer (red).
Fig. 3
Fig. 3 The lateral resolution of HM-OR-PAM over the 12-mm scanning range. (a) Lateral resolution as a function of the laser spot position along the x-axis. (b) The measured FWHM of the LSF at a representative position of x = −4 mm.
Fig. 4
Fig. 4 The fast-scanning step size of the hexagon-mirror scanner. (a) Average fast-scanning step size over the 12-mm scanning range as a function of the laser PRR and B-scan rate. (b) The relative scanning step size normalized by that at x = 0.
Fig. 5
Fig. 5 Validation of the HM-OR-PAM imaging performance. (a) HM-OR-PAM of a red leaf skeleton phantom with a B-scan rate of 420 Hz and 900 Hz. (b) HM-OR-PAM of mouse ear vasculature in vivo with a B-scan rate of 420 Hz and 900 Hz.
Fig. 6
Fig. 6 HM-OR-PAM of the drug responses in a mouse ear. (a) Representative vasculature images of the entire mouse ear at different time points after the epinephrine injection. (b) Close-up images of the region indicated by the dashed box in (a), showing the microvessel constriction (yellow arrows). (c) The relative change in PA signal amplitude before and after epinephrine injection, showing that the smaller vessels experienced stronger drug effect. (d) The time course of average PA signal amplitude over the entire mouse ear before and after the drug injection.
Fig. 7
Fig. 7 Histological slices of brain infarction after ischemic stroke. The mouse was sacrificed 24 hours after the MCA surgery and brain infarction (white) was detected by the 2,3,5-triphenyltetrazolium chloride staining method.
Fig. 8
Fig. 8 HM-OR-PAM of vascular reperfusion after ischemic stroke in a mouse brain. (a) The baseline HM-OR-PAM image of the cortical vasculature before the monofilament was inserted into the left MAC. (b) The vessel-by-vessel map of the relative change in the PA signal amplitude 10 minutes after the monofilament withdrawal, showing the blood reperfusion mainly concentrated in the left hemisphere. The PA image at the 60-sec time point was used as the baseline. (c) The relative change in the PA signal amplitude (shown in color) 240 seconds (left) and 600 seconds (right) after the monofilament withdrawal, superimposed on the baseline image (shown in gray). To highlight the different delay time in reperfusion, we used different baselines when changes were quantified. The 240-sec PA image was compared with the 60-sec PA image, and the 600-sec PA image was compared with the 300-sec image. (d) The time courses of the PA signal amplitude change in the selected regions (boxed regions in (a)) in the left front (LF), left middle (LM) and right middle (RM) cortex, showing the heterogenous magnitude and delay in the vascular reperfusion. (e) A vessel-by-vessel map of the reperfusion delay in the entire mouse cortex.