Abstract

A new approach in early cancer detection focuses on detecting field cancerization (FC) instead of the tumor itself. The aim of the current study is to investigate whether reflectance spectroscopy can detect FC in the buccal mucosa of patients with laryngeal cancer. The optical properties of the buccal mucosa of patients were measured with multidiameter single-fiber reflectance spectroscopy. The blood oxygen saturation and blood volume fraction were significantly lower in the buccal mucosa of laryngeal cancer patients than in non-oncologic controls. The data of these two parameters were combined to form a single ‘biomarker α’, which optimally discriminates these two groups. Alpha was lower in the laryngeal cancer group (0.28) than the control group (0.30, p = 0.007). Alpha could identify oncologic patients with a sensitivity of 78% and a specificity of 74%. These results might be the first step toward optical pre-screening for laryngeal cancer.

© 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Full Article  |  PDF Article
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  1. J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
    [Crossref] [PubMed]
  2. F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
    [Crossref] [PubMed]
  3. H. Mehanna, V. Paleri, C. M. West, and C. Nutting, “Head and neck cancer--Part 1: Epidemiology, presentation, and prevention,” BMJ 341(sep20 1), c4684 (2010).
    [Crossref] [PubMed]
  4. H. Mehanna, C. M. West, C. Nutting, and V. Paleri, “Head and neck cancer--Part 2: Treatment and prognostic factors,” BMJ 341(sep28 2), c4690 (2010).
    [Crossref] [PubMed]
  5. F. R. Datema, M. B. Ferrier, M. P. van der Schroeff, and R. J. Baatenburg de Jong, “Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients,” Head Neck 32(6), 728–736 (2010).
    [PubMed]
  6. R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
    [Crossref] [PubMed]
  7. S. F. Hall, P. A. Groome, D. Rothwell, and P. F. Dixon, “Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck,” Head Neck 21(1), 30–38 (1999).
    [Crossref] [PubMed]
  8. S. N. Whang, M. Filippova, and P. Duerksen-Hughes, “Recent progress in therapeutic treatments and screening strategies for the prevention and treatment of HPV-associated head and neck cancer,” Viruses 7(9), 5040–5065 (2015).
    [Crossref] [PubMed]
  9. D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
    [Crossref] [PubMed]
  10. E. R. Hapner and J. C. Wise, “Results of a large-scale head and neck cancer screening of an at-risk population,” J. Voice 25(4), 480–483 (2011).
    [Crossref] [PubMed]
  11. H. Nunn, A. Lalli, F. Fortune, and R. Croucher, “Oral cancer screening in the Bangladeshi community of Tower Hamlets: a social model,” Br. J. Cancer 101(S2), S68–S72 (2009).
    [Crossref] [PubMed]
  12. E. M. O’Sullivan, “Prevalence of oral mucosal abnormalities in addiction treatment centre residents in Southern Ireland,” Oral Oncol. 47(5), 395–399 (2011).
    [Crossref] [PubMed]
  13. R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
    [Crossref] [PubMed]
  14. H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
    [Crossref] [PubMed]
  15. L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
    [PubMed]
  16. D. Sidransky, “The oral cavity as a molecular mirror of lung carcinogenesis,” Cancer Prev. Res. (Phila.) 1(1), 12–14 (2008).
    [Crossref] [PubMed]
  17. H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
    [Crossref] [PubMed]
  18. Dj. Evers, B. Hendriks, G. Lucassen, and T. Ruers, “Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy,” Future Oncol. 8(3), 307–320 (2012).
    [Crossref] [PubMed]
  19. C. L. Hoy, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method for rapid multidiameter single-fiber reflectance and fluorescence spectroscopy through a fiber bundle,” J. Biomed. Opt. 18(10), 107005 (2013).
    [Crossref] [PubMed]
  20. S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth,” Phys. Med. Biol. 54(22), 6991–7008 (2009).
    [Crossref] [PubMed]
  21. S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
    [Crossref] [PubMed]
  22. S. C. Kanick, U. A. Gamm, M. Schouten, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of the reduced scattering coefficient of turbid media using single fiber reflectance spectroscopy: fiber diameter and phase function dependence,” Biomed. Opt. Express 2(6), 1687–1702 (2011).
    [Crossref] [PubMed]
  23. S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Method to quantitate absorption coefficients from single fiber reflectance spectra without knowledge of the scattering properties,” Opt. Lett. 36(15), 2791–2793 (2011).
    [Crossref] [PubMed]
  24. S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
    [Crossref] [PubMed]
  25. U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
    [Crossref] [PubMed]
  26. U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Quantification of the reduced scattering coefficient and phase-function-dependent parameter γ of turbid media using multidiameter single fiber reflectance spectroscopy: experimental validation,” Opt. Lett. 37(11), 1838–1840 (2012).
    [Crossref] [PubMed]
  27. V. Turzhitsky, A. Radosevich, J. D. Rogers, A. Taflove, and V. Backman, “A predictive model of backscattering at subdiffusion length scales,” Biomed. Opt. Express 1(3), 1034–1046 (2010).
    [Crossref] [PubMed]
  28. O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
    [Crossref] [PubMed]
  29. A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
    [Crossref] [PubMed]
  30. V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
    [Crossref] [PubMed]
  31. H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
    [Crossref] [PubMed]
  32. S. C. Kanick, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium,” Opt. Lett. 36(15), 2997–2999 (2011).
    [Crossref] [PubMed]
  33. S. C. Kanick, H. J. Sterenborg, and A. Amelink, “Empirical model of the photon path length for a single fiber reflectance spectroscopy device,” Opt. Express 17(2), 860–871 (2009).
    [Crossref] [PubMed]
  34. P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
    [Crossref] [PubMed]
  35. P. R. Bargo, S. A. Prahl, and S. L. Jacques, “Collection efficiency of a single optical fiber in turbid media,” Appl. Opt. 42(16), 3187–3197 (2003).
    [Crossref] [PubMed]
  36. T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
    [Crossref] [PubMed]
  37. A. Amelink, T. Christiaanse, and H. J. Sterenborg, “Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation,” Opt. Lett. 34(10), 1525–1527 (2009).
    [Crossref] [PubMed]
  38. S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
    [Crossref] [PubMed]
  39. L. E. Fredenburgh, A. A. Merz, and S. Cheng, “Haeme oxygenase signalling pathway: implications for cardiovascular disease,” Eur. Heart J. 36(24), 1512–1518 (2015).
    [Crossref] [PubMed]
  40. R. Metzger, R. Wachowiak, and D. Kluth, “Embryology of the early foregut,” Semin. Pediatr. Surg. 20(3), 136–144 (2011).
    [Crossref] [PubMed]

2018 (1)

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

2017 (1)

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

2016 (1)

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

2015 (5)

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

S. N. Whang, M. Filippova, and P. Duerksen-Hughes, “Recent progress in therapeutic treatments and screening strategies for the prevention and treatment of HPV-associated head and neck cancer,” Viruses 7(9), 5040–5065 (2015).
[Crossref] [PubMed]

T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
[Crossref] [PubMed]

L. E. Fredenburgh, A. A. Merz, and S. Cheng, “Haeme oxygenase signalling pathway: implications for cardiovascular disease,” Eur. Heart J. 36(24), 1512–1518 (2015).
[Crossref] [PubMed]

2014 (1)

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

2013 (2)

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

C. L. Hoy, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method for rapid multidiameter single-fiber reflectance and fluorescence spectroscopy through a fiber bundle,” J. Biomed. Opt. 18(10), 107005 (2013).
[Crossref] [PubMed]

2012 (3)

Dj. Evers, B. Hendriks, G. Lucassen, and T. Ruers, “Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy,” Future Oncol. 8(3), 307–320 (2012).
[Crossref] [PubMed]

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Quantification of the reduced scattering coefficient and phase-function-dependent parameter γ of turbid media using multidiameter single fiber reflectance spectroscopy: experimental validation,” Opt. Lett. 37(11), 1838–1840 (2012).
[Crossref] [PubMed]

2011 (7)

S. C. Kanick, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium,” Opt. Lett. 36(15), 2997–2999 (2011).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of the reduced scattering coefficient of turbid media using single fiber reflectance spectroscopy: fiber diameter and phase function dependence,” Biomed. Opt. Express 2(6), 1687–1702 (2011).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Method to quantitate absorption coefficients from single fiber reflectance spectra without knowledge of the scattering properties,” Opt. Lett. 36(15), 2791–2793 (2011).
[Crossref] [PubMed]

E. R. Hapner and J. C. Wise, “Results of a large-scale head and neck cancer screening of an at-risk population,” J. Voice 25(4), 480–483 (2011).
[Crossref] [PubMed]

E. M. O’Sullivan, “Prevalence of oral mucosal abnormalities in addiction treatment centre residents in Southern Ireland,” Oral Oncol. 47(5), 395–399 (2011).
[Crossref] [PubMed]

R. Metzger, R. Wachowiak, and D. Kluth, “Embryology of the early foregut,” Semin. Pediatr. Surg. 20(3), 136–144 (2011).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
[Crossref] [PubMed]

2010 (7)

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

H. Mehanna, V. Paleri, C. M. West, and C. Nutting, “Head and neck cancer--Part 1: Epidemiology, presentation, and prevention,” BMJ 341(sep20 1), c4684 (2010).
[Crossref] [PubMed]

H. Mehanna, C. M. West, C. Nutting, and V. Paleri, “Head and neck cancer--Part 2: Treatment and prognostic factors,” BMJ 341(sep28 2), c4690 (2010).
[Crossref] [PubMed]

F. R. Datema, M. B. Ferrier, M. P. van der Schroeff, and R. J. Baatenburg de Jong, “Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients,” Head Neck 32(6), 728–736 (2010).
[PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

V. Turzhitsky, A. Radosevich, J. D. Rogers, A. Taflove, and V. Backman, “A predictive model of backscattering at subdiffusion length scales,” Biomed. Opt. Express 1(3), 1034–1046 (2010).
[Crossref] [PubMed]

2009 (6)

S. C. Kanick, H. J. Sterenborg, and A. Amelink, “Empirical model of the photon path length for a single fiber reflectance spectroscopy device,” Opt. Express 17(2), 860–871 (2009).
[Crossref] [PubMed]

A. Amelink, T. Christiaanse, and H. J. Sterenborg, “Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation,” Opt. Lett. 34(10), 1525–1527 (2009).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth,” Phys. Med. Biol. 54(22), 6991–7008 (2009).
[Crossref] [PubMed]

H. Nunn, A. Lalli, F. Fortune, and R. Croucher, “Oral cancer screening in the Bangladeshi community of Tower Hamlets: a social model,” Br. J. Cancer 101(S2), S68–S72 (2009).
[Crossref] [PubMed]

2008 (1)

D. Sidransky, “The oral cavity as a molecular mirror of lung carcinogenesis,” Cancer Prev. Res. (Phila.) 1(1), 12–14 (2008).
[Crossref] [PubMed]

2005 (1)

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

2003 (1)

2001 (1)

R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
[Crossref] [PubMed]

1999 (2)

S. F. Hall, P. A. Groome, D. Rothwell, and P. F. Dixon, “Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck,” Head Neck 21(1), 30–38 (1999).
[Crossref] [PubMed]

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Aerts, J. G.

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

Amelink, A.

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
[Crossref] [PubMed]

C. L. Hoy, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method for rapid multidiameter single-fiber reflectance and fluorescence spectroscopy through a fiber bundle,” J. Biomed. Opt. 18(10), 107005 (2013).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Quantification of the reduced scattering coefficient and phase-function-dependent parameter γ of turbid media using multidiameter single fiber reflectance spectroscopy: experimental validation,” Opt. Lett. 37(11), 1838–1840 (2012).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Method to quantitate absorption coefficients from single fiber reflectance spectra without knowledge of the scattering properties,” Opt. Lett. 36(15), 2791–2793 (2011).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium,” Opt. Lett. 36(15), 2997–2999 (2011).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of the reduced scattering coefficient of turbid media using single fiber reflectance spectroscopy: fiber diameter and phase function dependence,” Biomed. Opt. Express 2(6), 1687–1702 (2011).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

S. C. Kanick, H. J. Sterenborg, and A. Amelink, “Empirical model of the photon path length for a single fiber reflectance spectroscopy device,” Opt. Express 17(2), 860–871 (2009).
[Crossref] [PubMed]

A. Amelink, T. Christiaanse, and H. J. Sterenborg, “Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation,” Opt. Lett. 34(10), 1525–1527 (2009).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth,” Phys. Med. Biol. 54(22), 6991–7008 (2009).
[Crossref] [PubMed]

Annunziata, C.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Baatenburg de Jong, R. J.

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

F. R. Datema, M. B. Ferrier, M. P. van der Schroeff, and R. J. Baatenburg de Jong, “Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients,” Head Neck 32(6), 728–736 (2010).
[PubMed]

R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
[Crossref] [PubMed]

Backman, V.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

V. Turzhitsky, A. Radosevich, J. D. Rogers, A. Taflove, and V. Backman, “A predictive model of backscattering at subdiffusion length scales,” Biomed. Opt. Express 1(3), 1034–1046 (2010).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Bargo, P. R.

Becker, V.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Betz, C. S.

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Bogojevic, A.

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Bogovejic, A.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Bonsing, B. A.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Boogerd, L. S.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Brand, R. E.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Bray, F.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Briaire, J. J.

R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
[Crossref] [PubMed]

Bruno, M. J.

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

Bugter, O.

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

Buonaguro, F. M.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Buonaguro, L.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Caponigro, F.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Chang, J. S.

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Cheng, S.

L. E. Fredenburgh, A. A. Merz, and S. Cheng, “Haeme oxygenase signalling pathway: implications for cardiovascular disease,” Eur. Heart J. 36(24), 1512–1518 (2015).
[Crossref] [PubMed]

Cherkezyan, L.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Christiaanse, T.

Croucher, R.

H. Nunn, A. Lalli, F. Fortune, and R. Croucher, “Oral cancer screening in the Bangladeshi community of Tower Hamlets: a social model,” Br. J. Cancer 101(S2), S68–S72 (2009).
[Crossref] [PubMed]

Damania, D.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

Datema, F. R.

F. R. Datema, M. B. Ferrier, M. P. van der Schroeff, and R. J. Baatenburg de Jong, “Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients,” Head Neck 32(6), 728–736 (2010).
[PubMed]

Dijkstra, J.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Dikshit, R.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Dixon, P. F.

S. F. Hall, P. A. Groome, D. Rothwell, and P. F. Dixon, “Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck,” Head Neck 21(1), 30–38 (1999).
[Crossref] [PubMed]

Djamin, R. S.

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

Duerksen-Hughes, P.

S. N. Whang, M. Filippova, and P. Duerksen-Hughes, “Recent progress in therapeutic treatments and screening strategies for the prevention and treatment of HPV-associated head and neck cancer,” Viruses 7(9), 5040–5065 (2015).
[Crossref] [PubMed]

Dunn, B.

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Eser, S.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Evers, Dj.

Dj. Evers, B. Hendriks, G. Lucassen, and T. Ruers, “Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy,” Future Oncol. 8(3), 307–320 (2012).
[Crossref] [PubMed]

Ferguson, M. K.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Ferlay, J.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Ferrier, M. B.

F. R. Datema, M. B. Ferrier, M. P. van der Schroeff, and R. J. Baatenburg de Jong, “Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients,” Head Neck 32(6), 728–736 (2010).
[PubMed]

Filippova, M.

S. N. Whang, M. Filippova, and P. Duerksen-Hughes, “Recent progress in therapeutic treatments and screening strategies for the prevention and treatment of HPV-associated head and neck cancer,” Viruses 7(9), 5040–5065 (2015).
[Crossref] [PubMed]

Forman, D.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Fortune, F.

H. Nunn, A. Lalli, F. Fortune, and R. Croucher, “Oral cancer screening in the Bangladeshi community of Tower Hamlets: a social model,” Br. J. Cancer 101(S2), S68–S72 (2009).
[Crossref] [PubMed]

Fredenburgh, L. E.

L. E. Fredenburgh, A. A. Merz, and S. Cheng, “Haeme oxygenase signalling pathway: implications for cardiovascular disease,” Eur. Heart J. 36(24), 1512–1518 (2015).
[Crossref] [PubMed]

Gamm, U. A.

Gazdar, A. F.

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Gogarty, D. S.

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

Goldberg, M.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Goldberg, M. J.

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Gomes, A. J.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Gonzalez, M. H.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Gould, B.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

Greenwald, P.

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Groome, P. A.

S. F. Hall, P. A. Groome, D. Rothwell, and P. F. Dixon, “Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck,” Head Neck 21(1), 30–38 (1999).
[Crossref] [PubMed]

Hall, S. F.

S. F. Hall, P. A. Groome, D. Rothwell, and P. F. Dixon, “Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck,” Head Neck 21(1), 30–38 (1999).
[Crossref] [PubMed]

Hapner, E. R.

E. R. Hapner and J. C. Wise, “Results of a large-scale head and neck cancer screening of an at-risk population,” J. Voice 25(4), 480–483 (2011).
[Crossref] [PubMed]

Hendriks, B.

Dj. Evers, B. Hendriks, G. Lucassen, and T. Ruers, “Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy,” Future Oncol. 8(3), 307–320 (2012).
[Crossref] [PubMed]

Hensing, T.

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Hensing, T. A.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

Henson, D. E.

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Hermans, J.

R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
[Crossref] [PubMed]

Hoogsteden, H. C.

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

Hoy, C. L.

T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
[Crossref] [PubMed]

C. L. Hoy, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method for rapid multidiameter single-fiber reflectance and fluorescence spectroscopy through a fiber bundle,” J. Biomed. Opt. 18(10), 107005 (2013).
[Crossref] [PubMed]

Inderson, A.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Ionna, F.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Jacques, S. L.

Jameel, M.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Janssens, A. M.

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

Kanick, S. C.

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Quantification of the reduced scattering coefficient and phase-function-dependent parameter γ of turbid media using multidiameter single fiber reflectance spectroscopy: experimental validation,” Opt. Lett. 37(11), 1838–1840 (2012).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium,” Opt. Lett. 36(15), 2997–2999 (2011).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of the reduced scattering coefficient of turbid media using single fiber reflectance spectroscopy: fiber diameter and phase function dependence,” Biomed. Opt. Express 2(6), 1687–1702 (2011).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Method to quantitate absorption coefficients from single fiber reflectance spectra without knowledge of the scattering properties,” Opt. Lett. 36(15), 2791–2793 (2011).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

S. C. Kanick, H. J. Sterenborg, and A. Amelink, “Empirical model of the photon path length for a single fiber reflectance spectroscopy device,” Opt. Express 17(2), 860–871 (2009).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth,” Phys. Med. Biol. 54(22), 6991–7008 (2009).
[Crossref] [PubMed]

Kascáková, S.

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

Kelloff, G. J.

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Kim, Y.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Kinsella, J.

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

Kluth, D.

R. Metzger, R. Wachowiak, and D. Kluth, “Embryology of the early foregut,” Semin. Pediatr. Surg. 20(3), 136–144 (2011).
[Crossref] [PubMed]

Konda, V. J.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Koons, A.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Kopelovich, L.

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Kraft, M.

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Kromine, A.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Kuzniar, T.

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

Lalli, A.

H. Nunn, A. Lalli, F. Fortune, and R. Croucher, “Oral cancer screening in the Bangladeshi community of Tower Hamlets: a social model,” Br. J. Cancer 101(S2), S68–S72 (2009).
[Crossref] [PubMed]

le Cessie, S.

R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
[Crossref] [PubMed]

Lelieveldt, B. P.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Lucassen, G.

Dj. Evers, B. Hendriks, G. Lucassen, and T. Ruers, “Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy,” Future Oncol. 8(3), 307–320 (2012).
[Crossref] [PubMed]

Mathers, C.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Mathew, B.

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Mehanna, H.

H. Mehanna, V. Paleri, C. M. West, and C. Nutting, “Head and neck cancer--Part 1: Epidemiology, presentation, and prevention,” BMJ 341(sep20 1), c4684 (2010).
[Crossref] [PubMed]

H. Mehanna, C. M. West, C. Nutting, and V. Paleri, “Head and neck cancer--Part 2: Treatment and prognostic factors,” BMJ 341(sep28 2), c4690 (2010).
[Crossref] [PubMed]

Merz, A. A.

L. E. Fredenburgh, A. A. Merz, and S. Cheng, “Haeme oxygenase signalling pathway: implications for cardiovascular disease,” Eur. Heart J. 36(24), 1512–1518 (2015).
[Crossref] [PubMed]

Metzger, R.

R. Metzger, R. Wachowiak, and D. Kluth, “Embryology of the early foregut,” Semin. Pediatr. Surg. 20(3), 136–144 (2011).
[Crossref] [PubMed]

Middelburg, T. A.

T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
[Crossref] [PubMed]

Mohammed, J.

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Molenaar, J.

R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
[Crossref] [PubMed]

Morreau, H.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Muldoon, J.

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Mutyal, N. N.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

Muwonge, R.

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Neumann, H. A.

T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
[Crossref] [PubMed]

Nunn, H.

H. Nunn, A. Lalli, F. Fortune, and R. Croucher, “Oral cancer screening in the Bangladeshi community of Tower Hamlets: a social model,” Br. J. Cancer 101(S2), S68–S72 (2009).
[Crossref] [PubMed]

Nutting, C.

H. Mehanna, V. Paleri, C. M. West, and C. Nutting, “Head and neck cancer--Part 1: Epidemiology, presentation, and prevention,” BMJ 341(sep20 1), c4684 (2010).
[Crossref] [PubMed]

H. Mehanna, C. M. West, C. Nutting, and V. Paleri, “Head and neck cancer--Part 2: Treatment and prognostic factors,” BMJ 341(sep28 2), c4690 (2010).
[Crossref] [PubMed]

O’Neill, J. P.

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

O’Sullivan, E. M.

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

E. M. O’Sullivan, “Prevalence of oral mucosal abnormalities in addiction treatment centre residents in Southern Ireland,” Oral Oncol. 47(5), 395–399 (2011).
[Crossref] [PubMed]

Paleri, V.

H. Mehanna, C. M. West, C. Nutting, and V. Paleri, “Head and neck cancer--Part 2: Treatment and prognostic factors,” BMJ 341(sep28 2), c4690 (2010).
[Crossref] [PubMed]

H. Mehanna, V. Paleri, C. M. West, and C. Nutting, “Head and neck cancer--Part 1: Epidemiology, presentation, and prevention,” BMJ 341(sep20 1), c4684 (2010).
[Crossref] [PubMed]

Parkin, D. M.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Pass, H. I.

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

Pezzuto, F.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Pradhan, P.

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Prahl, S. A.

Prestin, S.

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Radosevich, A.

Radosevich, A. J.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

Rajan, B.

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Ramadas, K.

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Ray, D.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Rebelo, M.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Robinson, D. J.

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
[Crossref] [PubMed]

C. L. Hoy, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method for rapid multidiameter single-fiber reflectance and fluorescence spectroscopy through a fiber bundle,” J. Biomed. Opt. 18(10), 107005 (2013).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Quantification of the reduced scattering coefficient and phase-function-dependent parameter γ of turbid media using multidiameter single fiber reflectance spectroscopy: experimental validation,” Opt. Lett. 37(11), 1838–1840 (2012).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of the reduced scattering coefficient of turbid media using single fiber reflectance spectroscopy: fiber diameter and phase function dependence,” Biomed. Opt. Express 2(6), 1687–1702 (2011).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium,” Opt. Lett. 36(15), 2997–2999 (2011).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Method to quantitate absorption coefficients from single fiber reflectance spectra without knowledge of the scattering properties,” Opt. Lett. 36(15), 2791–2793 (2011).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth,” Phys. Med. Biol. 54(22), 6991–7008 (2009).
[Crossref] [PubMed]

Rogers, J. D.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

V. Turzhitsky, A. Radosevich, J. D. Rogers, A. Taflove, and V. Backman, “A predictive model of backscattering at subdiffusion length scales,” Biomed. Opt. Express 1(3), 1034–1046 (2010).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Rom, W. N.

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

Rothschild, S. I.

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Rothwell, D.

S. F. Hall, P. A. Groome, D. Rothwell, and P. F. Dixon, “Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck,” Head Neck 21(1), 30–38 (1999).
[Crossref] [PubMed]

Roy, H. K.

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Ruers, T.

Dj. Evers, B. Hendriks, G. Lucassen, and T. Ruers, “Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy,” Future Oncol. 8(3), 307–320 (2012).
[Crossref] [PubMed]

Sankaranarayanan, R.

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Schouten, M.

Shah, M.

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

Sheahan, P.

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

Shuman, A.

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

Sidransky, D.

D. Sidransky, “The oral cavity as a molecular mirror of lung carcinogenesis,” Cancer Prev. Res. (Phila.) 1(1), 12–14 (2008).
[Crossref] [PubMed]

Soerjomataram, I.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Spaander, M. C. W.

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

Srivastava, S.

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Starita, N.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Stegehuis, P. L.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Sterenborg, H. J.

C. L. Hoy, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method for rapid multidiameter single-fiber reflectance and fluorescence spectroscopy through a fiber bundle,” J. Biomed. Opt. 18(10), 107005 (2013).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Quantification of the reduced scattering coefficient and phase-function-dependent parameter γ of turbid media using multidiameter single fiber reflectance spectroscopy: experimental validation,” Opt. Lett. 37(11), 1838–1840 (2012).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method to quantitatively estimate wavelength-dependent scattering properties from multidiameter single fiber reflectance spectra measured in a turbid medium,” Opt. Lett. 36(15), 2997–2999 (2011).
[Crossref] [PubMed]

U. A. Gamm, S. C. Kanick, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of tissue scattering properties using multi-diameter single fiber reflectance spectroscopy: in silico sensitivity analysis,” Biomed. Opt. Express 2(11), 3150–3166 (2011).
[Crossref] [PubMed]

S. C. Kanick, U. A. Gamm, M. Schouten, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Measurement of the reduced scattering coefficient of turbid media using single fiber reflectance spectroscopy: fiber diameter and phase function dependence,” Biomed. Opt. Express 2(6), 1687–1702 (2011).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Method to quantitate absorption coefficients from single fiber reflectance spectra without knowledge of the scattering properties,” Opt. Lett. 36(15), 2791–2793 (2011).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

S. C. Kanick, H. J. Sterenborg, and A. Amelink, “Empirical model of the photon path length for a single fiber reflectance spectroscopy device,” Opt. Express 17(2), 860–871 (2009).
[Crossref] [PubMed]

A. Amelink, T. Christiaanse, and H. J. Sterenborg, “Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation,” Opt. Lett. 34(10), 1525–1527 (2009).
[Crossref] [PubMed]

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth,” Phys. Med. Biol. 54(22), 6991–7008 (2009).
[Crossref] [PubMed]

Sturgis, C.

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Subramanian, H.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

Sven Mieog, J.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Taflove, A.

Thara, S.

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Thomas, G.

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Timon, C.

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

Tornesello, M. L.

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Turzhitsky, V.

V. Turzhitsky, A. Radosevich, J. D. Rogers, A. Taflove, and V. Backman, “A predictive model of backscattering at subdiffusion length scales,” Biomed. Opt. Express 1(3), 1034–1046 (2010).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Vahrmeijer, A. L.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

van de Velde, C. J.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

van der Leest, C.

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

van der Schroeff, M. P.

F. R. Datema, M. B. Ferrier, M. P. van der Schroeff, and R. J. Baatenburg de Jong, “Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients,” Head Neck 32(6), 728–736 (2010).
[PubMed]

van Gerven, P.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Veenendaal, R. A.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Veselic, M.

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

Wachowiak, R.

R. Metzger, R. Wachowiak, and D. Kluth, “Embryology of the early foregut,” Semin. Pediatr. Surg. 20(3), 136–144 (2011).
[Crossref] [PubMed]

Watson, P.

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Waxman, I.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

West, C. M.

H. Mehanna, V. Paleri, C. M. West, and C. Nutting, “Head and neck cancer--Part 1: Epidemiology, presentation, and prevention,” BMJ 341(sep20 1), c4684 (2010).
[Crossref] [PubMed]

H. Mehanna, C. M. West, C. Nutting, and V. Paleri, “Head and neck cancer--Part 2: Treatment and prognostic factors,” BMJ 341(sep28 2), c4690 (2010).
[Crossref] [PubMed]

Whang, S. N.

S. N. Whang, M. Filippova, and P. Duerksen-Hughes, “Recent progress in therapeutic treatments and screening strategies for the prevention and treatment of HPV-associated head and neck cancer,” Viruses 7(9), 5040–5065 (2015).
[Crossref] [PubMed]

Wise, J. C.

E. R. Hapner and J. C. Wise, “Results of a large-scale head and neck cancer screening of an at-risk population,” J. Voice 25(4), 480–483 (2011).
[Crossref] [PubMed]

Wroblewski, K.

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (3)

BMJ (2)

H. Mehanna, V. Paleri, C. M. West, and C. Nutting, “Head and neck cancer--Part 1: Epidemiology, presentation, and prevention,” BMJ 341(sep20 1), c4684 (2010).
[Crossref] [PubMed]

H. Mehanna, C. M. West, C. Nutting, and V. Paleri, “Head and neck cancer--Part 2: Treatment and prognostic factors,” BMJ 341(sep28 2), c4690 (2010).
[Crossref] [PubMed]

Br. J. Cancer (1)

H. Nunn, A. Lalli, F. Fortune, and R. Croucher, “Oral cancer screening in the Bangladeshi community of Tower Hamlets: a social model,” Br. J. Cancer 101(S2), S68–S72 (2009).
[Crossref] [PubMed]

Cancer Prev. Res. (Phila.) (1)

D. Sidransky, “The oral cavity as a molecular mirror of lung carcinogenesis,” Cancer Prev. Res. (Phila.) 1(1), 12–14 (2008).
[Crossref] [PubMed]

Cancer Res. (3)

H. Subramanian, H. K. Roy, P. Pradhan, M. J. Goldberg, J. Muldoon, R. E. Brand, C. Sturgis, T. Hensing, D. Ray, A. Bogojevic, J. Mohammed, J. S. Chang, and V. Backman, “Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy,” Cancer Res. 69(13), 5357–5363 (2009).
[Crossref] [PubMed]

H. K. Roy, H. Subramanian, D. Damania, T. A. Hensing, W. N. Rom, H. I. Pass, D. Ray, J. D. Rogers, A. Bogojevic, M. Shah, T. Kuzniar, P. Pradhan, and V. Backman, “Optical detection of buccal epithelial nanoarchitectural alterations in patients harboring lung cancer: implications for screening,” Cancer Res. 70(20), 7748–7754 (2010).
[Crossref] [PubMed]

H. K. Roy, V. Turzhitsky, Y. Kim, M. J. Goldberg, P. Watson, J. D. Rogers, A. J. Gomes, A. Kromine, R. E. Brand, M. Jameel, A. Bogovejic, P. Pradhan, and V. Backman, “Association between rectal optical signatures and colonic neoplasia: potential applications for screening,” Cancer Res. 69(10), 4476–4483 (2009).
[Crossref] [PubMed]

Clin. Cancer Res. (1)

L. Kopelovich, D. E. Henson, A. F. Gazdar, B. Dunn, S. Srivastava, G. J. Kelloff, and P. Greenwald, “Surrogate anatomic/functional sites for evaluating cancer risk: an extension of the field effect,” Clin. Cancer Res. 5(12), 3899–3905 (1999).
[PubMed]

Clin. Transl. Gastroenterol. (1)

O. Bugter, M. C. W. Spaander, M. J. Bruno, R. J. Baatenburg de Jong, A. Amelink, and D. J. Robinson, “Optical detection of field cancerization in the buccal mucosa of patients with esophageal cancer,” Clin. Transl. Gastroenterol. 9(4), 152 (2018).
[Crossref] [PubMed]

Endoscopy (1)

V. J. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. H. Gonzalez, A. Koons, M. Goldberg, M. K. Ferguson, I. Waxman, H. K. Roy, and V. Backman, “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening,” Endoscopy 45(12), 983–988 (2013).
[Crossref] [PubMed]

Eur. Heart J. (1)

L. E. Fredenburgh, A. A. Merz, and S. Cheng, “Haeme oxygenase signalling pathway: implications for cardiovascular disease,” Eur. Heart J. 36(24), 1512–1518 (2015).
[Crossref] [PubMed]

Future Oncol. (1)

Dj. Evers, B. Hendriks, G. Lucassen, and T. Ruers, “Optical spectroscopy: current advances and future applications in cancer diagnostics and therapy,” Future Oncol. 8(3), 307–320 (2012).
[Crossref] [PubMed]

Head Neck (4)

F. R. Datema, M. B. Ferrier, M. P. van der Schroeff, and R. J. Baatenburg de Jong, “Impact of comorbidity on short-term mortality and overall survival of head and neck cancer patients,” Head Neck 32(6), 728–736 (2010).
[PubMed]

R. J. Baatenburg de Jong, J. Hermans, J. Molenaar, J. J. Briaire, and S. le Cessie, “Prediction of survival in patients with head and neck cancer,” Head Neck 23(9), 718–724 (2001).
[Crossref] [PubMed]

S. F. Hall, P. A. Groome, D. Rothwell, and P. F. Dixon, “Using TNM staging to predict survival in patients with squamous cell carcinoma of head & neck,” Head Neck 21(1), 30–38 (1999).
[Crossref] [PubMed]

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Int. J. Cancer (1)

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

J. Biomed. Opt. (3)

C. L. Hoy, U. A. Gamm, H. J. Sterenborg, D. J. Robinson, and A. Amelink, “Method for rapid multidiameter single-fiber reflectance and fluorescence spectroscopy through a fiber bundle,” J. Biomed. Opt. 18(10), 107005 (2013).
[Crossref] [PubMed]

P. L. Stegehuis, L. S. Boogerd, A. Inderson, R. A. Veenendaal, P. van Gerven, B. A. Bonsing, J. Sven Mieog, A. Amelink, M. Veselic, H. Morreau, C. J. van de Velde, B. P. Lelieveldt, J. Dijkstra, D. J. Robinson, and A. L. Vahrmeijer, “Toward optical guidance during endoscopic ultrasound-guided fine needle aspirations of pancreatic masses using single fiber reflectance spectroscopy: a feasibility study,” J. Biomed. Opt. 22(2), 024001 (2017).
[Crossref] [PubMed]

S. C. Kanick, C. van der Leest, J. G. Aerts, H. C. Hoogsteden, S. Kascáková, H. J. Sterenborg, and A. Amelink, “Integration of single-fiber reflectance spectroscopy into ultrasound-guided endoscopic lung cancer staging of mediastinal lymph nodes,” J. Biomed. Opt. 15(1), 017004 (2010).
[Crossref] [PubMed]

J. Dermatol. Sci. (1)

T. A. Middelburg, C. L. Hoy, H. A. Neumann, A. Amelink, and D. J. Robinson, “Correction for tissue optical properties enables quantitative skin fluorescence measurements using multi-diameter single fiber reflectance spectroscopy,” J. Dermatol. Sci. 79(1), 64–73 (2015).
[Crossref] [PubMed]

J. Laryngol. Otol. (1)

D. S. Gogarty, A. Shuman, E. M. O’Sullivan, P. Sheahan, J. Kinsella, C. Timon, and J. P. O’Neill, “Conceiving a national head and neck cancer screening programme,” J. Laryngol. Otol. 130(1), 8–14 (2016).
[Crossref] [PubMed]

J. Thorac. Oncol. (1)

S. C. Kanick, C. van der Leest, R. S. Djamin, A. M. Janssens, H. C. Hoogsteden, H. J. Sterenborg, A. Amelink, and J. G. Aerts, “Characterization of mediastinal lymph node physiology in vivo by optical spectroscopy during endoscopic ultrasound-guided fine needle aspiration,” J. Thorac. Oncol. 5(7), 981–987 (2010).
[Crossref] [PubMed]

J. Voice (1)

E. R. Hapner and J. C. Wise, “Results of a large-scale head and neck cancer screening of an at-risk population,” J. Voice 25(4), 480–483 (2011).
[Crossref] [PubMed]

Lancet (1)

R. Sankaranarayanan, K. Ramadas, G. Thomas, R. Muwonge, S. Thara, B. Mathew, B. Rajan, and Trivandrum Oral Cancer Screening Study Group, “Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial,” Lancet 365(9475), 1927–1933 (2005).
[Crossref] [PubMed]

Oncology (1)

F. Pezzuto, L. Buonaguro, F. Caponigro, F. Ionna, N. Starita, C. Annunziata, F. M. Buonaguro, and M. L. Tornesello, “Update on head and neck cancer: current knowledge on epidemiology, risk factors, molecular features and novel therapies,” Oncology 89(3), 125–136 (2015).
[Crossref] [PubMed]

Opt. Express (1)

Opt. Lett. (4)

Oral Oncol. (1)

E. M. O’Sullivan, “Prevalence of oral mucosal abnormalities in addiction treatment centre residents in Southern Ireland,” Oral Oncol. 47(5), 395–399 (2011).
[Crossref] [PubMed]

Phys. Med. Biol. (1)

S. C. Kanick, D. J. Robinson, H. J. Sterenborg, and A. Amelink, “Monte Carlo analysis of single fiber reflectance spectroscopy: photon path length and sampling depth,” Phys. Med. Biol. 54(22), 6991–7008 (2009).
[Crossref] [PubMed]

PLoS One (1)

A. J. Radosevich, N. N. Mutyal, J. D. Rogers, B. Gould, T. A. Hensing, D. Ray, V. Backman, and H. K. Roy, “Buccal spectral markers for lung cancer risk stratification,” PLoS One 9(10), e110157 (2014).
[Crossref] [PubMed]

Semin. Pediatr. Surg. (1)

R. Metzger, R. Wachowiak, and D. Kluth, “Embryology of the early foregut,” Semin. Pediatr. Surg. 20(3), 136–144 (2011).
[Crossref] [PubMed]

Viruses (1)

S. N. Whang, M. Filippova, and P. Duerksen-Hughes, “Recent progress in therapeutic treatments and screening strategies for the prevention and treatment of HPV-associated head and neck cancer,” Viruses 7(9), 5040–5065 (2015).
[Crossref] [PubMed]

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Figures (5)

Fig. 1
Fig. 1 Multidiameter single-fiber reflectance spectroscopy measurement. Subject is a volunteer who gave written consent to use and publish her image. A) Overview of setup with patient, probe, and laptop for data storage. B) Placement of probe tip on the buccal mucosa. C) Close-up of probe tip.
Fig. 2
Fig. 2 A schematic representation of the MDSFR device with numbering of the fiber cores, trifurcation at the proximal end of each fiber in the bundle, and the fiber tree. A photograph of the fiber tree is added on the right.
Fig. 3
Fig. 3 Example of spectra acquired from the buccal mucosa of A) a patient with a laryngeal tumor and B) a non-oncologic control. The three lines per patient represent the spectra derived from the effective 200, 600 and 1000 µm fiber diameters. Patient A features a lower absorption coefficient in the wavelength region from 500 to 600 nm (indicated by vertical dashed lines). The spectrum from patient A correlates with a lower blood oxygen saturation and blood volume fraction and consequently a lower value of biomarker α than patient B.
Fig. 4
Fig. 4 Values of BVF split up per T-stage versus non-oncologic control group. Median values are plotted in squares. Error bars represent interquartile range. * = p-value <0.05. P-values calculated with Mann-Whitney U test. Cis = carcinoma in situ, T1-3 = T-stage 1-3.
Fig. 5
Fig. 5 ROC curve of biomarker α (composed of BVF and StO2). AUC = area under the curve.

Tables (2)

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Table 1 Patient demographics

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Table 2 Results of MDSFR physiological parameters

Equations (11)

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R SF = R SF 0 e μ a L SFR ,
L SFR d f = C PF p 1 ( μ s ' ) p 2 [ p 3 + ( μ a d f ) p 3 ] ,
R SF 0 = η lim ( 1+ p 6 e p 4 μ s ' d f )[ μ s ' d f p 5 p 4 + ( μ s ' d f ) p 5 ],
W center = 1 12 I outer int.sphere I center int.sphere
W center = 6 12 I outer int.sphere I middle int.sphere .
I small eff = I center ,
I med eff = W center I center + W middle I middle ,
I large eff = W center I center + W middle I middle + I outer .
R SF = R cal sim I meas eff I water eff I cal eff I water eff .
μ a tissue =ρ C v ( StO 2 μ a HbO 2 +( 1 StO 2 ) μ a Hb )+ μ a bil [BIL] tis .
C v = { 1exp( ( StO 2 μ a HbO 2 +( 1 StO 2 ) μ a Hb ) D v ) } { ( StO 2 μ a HbO 2 +( 1 StO 2 ) μ a Hb ) D v }

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