Abstract

We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2∙ 417 kHz  =  834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 µm axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 nm sweep range, as well as to existing spectral domain OCT data with 2.1 µm axial resolution from literature. We identify benefits of the higher resolution, for example the improved visualization of small blood vessels in the retina besides several others.

© 2017 Optical Society of America

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2017 (6)

2016 (1)

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

2015 (4)

2014 (4)

W. Wieser, W. Draxinger, T. Klein, S. Karpf, T. Pfeiffer, and R. Huber, “High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s,” Biomed. Opt. Express 5(9), 2963–2977 (2014).
[PubMed]

O. P. Kocaoglu, T. L. Turner, Z. Liu, and D. T. Miller, “Adaptive optics optical coherence tomography at 1 MHz,” Biomed. Opt. Express 5(12), 4186–4200 (2014).
[PubMed]

G. Staurenghi, S. Sadda, U. Chakravarthy, R. F. Spaide, and International Nomenclature for Optical Coherence Tomography (IN•OCT) Panel, “Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN*OCT consensus,” Ophthalmology 121(8), 1572–1578 (2014).
[PubMed]

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

2013 (3)

C. M. Eigenwillig, W. Wieser, S. Todor, B. R. Biedermann, T. Klein, C. Jirauschek, and R. Huber, “Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers,” Nat. Commun. 4, 1848 (2013).
[PubMed]

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[PubMed]

2012 (6)

2011 (2)

2010 (4)

2009 (1)

2007 (1)

2006 (3)

2005 (3)

2004 (4)

2003 (2)

2001 (1)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

1998 (1)

1997 (4)

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett. 22(5), 340–342 (1997).
[PubMed]

B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser,” Opt. Lett. 22(22), 1704–1706 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
[PubMed]

1995 (2)

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
[PubMed]

J. M. Schmitt, M. J. Yadlowsky, and R. F. Bonner, “Subsurface imaging of living skin with optical coherence microscopy,” Dermatology (Basel) 191(2), 93–98 (1995).
[PubMed]

1994 (1)

1993 (2)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, “In vivo optical coherence tomography,” Am. J. Ophthalmol. 116(1), 113–114 (1993).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

1973 (1)

Adler, D. C.

Ahrens, G.

Akcay, A. C.

Alex, A.

Andersen, P.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

Andersen, P. E.

Andre, R.

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt. 17, 0705051 (2012).

Atkinson, D.

Bailey, S. T.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Bajraszewski, T.

Barry, S.

Bauer, S.

Baumann, B.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[PubMed]

Biedermann, B.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

S. Todor, B. Biedermann, W. Wieser, R. Huber, and C. Jirauschek, “Instantaneous lineshape analysis of Fourier domain mode-locked lasers,” Opt. Express 19(9), 8802–8807 (2011).
[PubMed]

C. Jirauschek, B. Biedermann, and R. Huber, “A theoretical description of Fourier domain mode locked lasers,” Opt. Express 17(26), 24013–24019 (2009).
[PubMed]

Biedermann, B. R.

Blatter, C.

Bonesi, M.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

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G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

Bouma, B.

Bouma, B. E.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
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B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser,” Opt. Lett. 22(22), 1704–1706 (1997).
[PubMed]

Bower, B. A.

Brenner, M.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

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G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
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G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
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Cable, A. E.

Cense, B.

Chakravarthy, U.

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Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Chen, T.

Chen, Z.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Chinn, S. R.

Choi, S.

Colston, B.

Colt, H.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Dasilva, L.

de Boer, J.

Draxinger, W.

Drexler, W.

C. Blatter, J. Weingast, A. Alex, B. Grajciar, W. Wieser, W. Drexler, R. Huber, and R. A. Leitgeb, “In situ structural and microangiographic assessment of human skin lesions with high-speed OCT,” Biomed. Opt. Express 3(10), 2636–2646 (2012).
[PubMed]

R. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. Fercher, “Ultrahigh resolution Fourier domain optical coherence tomography,” Opt. Express 12(10), 2156–2165 (2004).
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W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, “In vivo optical coherence tomography,” Am. J. Ophthalmol. 116(1), 113–114 (1993).
[PubMed]

Duker, J.

Duker, J. S.

Eibl, M.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “Shot-Noise Limited Time-Encoded Raman Spectroscopy,” J. Spectrosc. 2017, 9253475 (2017).

M. Eibl, S. Karpf, D. Weng, H. Hakert, T. Pfeiffer, J. P. Kolb, and R. Huber, “Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate,” Biomed. Opt. Express 8(7), 3132–3142 (2017).
[PubMed]

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6, 6784 (2015).
[PubMed]

Eichenholz, J. M.

Eigenwillig, C. M.

Engelke, R.

Erbert, G.

Everett, M.

Fercher, A.

Fercher, A. F.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, “In vivo optical coherence tomography,” Am. J. Ophthalmol. 116(1), 113–114 (1993).
[PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Fujimoto, J.

Fujimoto, J. G.

E. A. Swanson and J. G. Fujimoto, “The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact Invited,” Biomed. Opt. Express 8(3), 1638–1664 (2017).
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I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[PubMed]

R. Huber, D. C. Adler, and J. G. Fujimoto, “Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s,” Opt. Lett. 31(20), 2975–2977 (2006).
[PubMed]

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14(8), 3225–3237 (2006).
[PubMed]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett. 22(5), 340–342 (1997).
[PubMed]

B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser,” Opt. Lett. 22(22), 1704–1706 (1997).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
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J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical Coherence Microscopy in Scattering Media,” Opt. Lett. 19(8), 590–592 (1994).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Ghanta, R. K.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

Goetzinger, E.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

Golubovic, B.

Götzinger, E.

Grajciar, B.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Gruber, A.

Grulkowski, I.

Grützner, G.

Guo, S.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Hakert, H.

Hale, G. M.

Hanna, N.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Hansen, K. P.

Hanson, S. R.

Hasler, K.-H.

Hee, M. R.

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
[PubMed]

J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical Coherence Microscopy in Scattering Media,” Opt. Lett. 19(8), 590–592 (1994).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Hermann, B.

Hitzenberger, C.

Hitzenberger, C. K.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, “In vivo optical coherence tomography,” Am. J. Ophthalmol. 116(1), 113–114 (1993).
[PubMed]

Hong, Y.

Hsu, K.

Huang, D.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Huber, R.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “Shot-Noise Limited Time-Encoded Raman Spectroscopy,” J. Spectrosc. 2017, 9253475 (2017).

M. Eibl, S. Karpf, D. Weng, H. Hakert, T. Pfeiffer, J. P. Kolb, and R. Huber, “Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate,” Biomed. Opt. Express 8(7), 3132–3142 (2017).
[PubMed]

T. Klein and R. Huber, “High-speed OCT light sources and systems,” Biomed. Opt. Express 8(2), 828–859 (2017).
[PubMed]

C. Jirauschek and R. Huber, “Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers,” J. Opt. Soc. Am. B 34, 1135–1146 (2017).

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[PubMed]

C. Jirauschek and R. Huber, “Modeling and analysis of polarization effects in Fourier domain mode-locked lasers,” Opt. Lett. 40(10), 2385–2388 (2015).
[PubMed]

C. Jirauschek and R. Huber, “Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers,” Biomed. Opt. Express 6(7), 2448–2465 (2015).
[PubMed]

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6, 6784 (2015).
[PubMed]

W. Wieser, W. Draxinger, T. Klein, S. Karpf, T. Pfeiffer, and R. Huber, “High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s,” Biomed. Opt. Express 5(9), 2963–2977 (2014).
[PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[PubMed]

C. M. Eigenwillig, W. Wieser, S. Todor, B. R. Biedermann, T. Klein, C. Jirauschek, and R. Huber, “Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers,” Nat. Commun. 4, 1848 (2013).
[PubMed]

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt. 17, 0705051 (2012).

W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express 3(10), 2647–2657 (2012).
[PubMed]

C. Blatter, B. Grajciar, P. Zou, W. Wieser, A.-J. Verhoef, R. Huber, and R. A. Leitgeb, “Intrasweep phase-sensitive optical coherence tomography for noncontact optical photoacoustic imaging,” Opt. Lett. 37(21), 4368–4370 (2012).
[PubMed]

C. Blatter, J. Weingast, A. Alex, B. Grajciar, W. Wieser, W. Drexler, R. Huber, and R. A. Leitgeb, “In situ structural and microangiographic assessment of human skin lesions with high-speed OCT,” Biomed. Opt. Express 3(10), 2636–2646 (2012).
[PubMed]

W. Wieser, G. Palte, C. M. Eigenwillig, B. R. Biedermann, T. Pfeiffer, and R. Huber, “Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools,” Opt. Express 20(9), 9819–9832 (2012).
[PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[PubMed]

S. Todor, B. Biedermann, W. Wieser, R. Huber, and C. Jirauschek, “Instantaneous lineshape analysis of Fourier domain mode-locked lasers,” Opt. Express 19(9), 8802–8807 (2011).
[PubMed]

S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K.-H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express 18(15), 15820–15831 (2010).
[PubMed]

B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Direct measurement of the instantaneous linewidth of rapidly wavelength-swept lasers,” Opt. Lett. 35(22), 3733–3735 (2010).
[PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[PubMed]

C. Jirauschek, B. Biedermann, and R. Huber, “A theoretical description of Fourier domain mode locked lasers,” Opt. Express 17(26), 24013–24019 (2009).
[PubMed]

R. Huber, D. C. Adler, and J. G. Fujimoto, “Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s,” Opt. Lett. 31(20), 2975–2977 (2006).
[PubMed]

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14(8), 3225–3237 (2006).
[PubMed]

Hurst, S.

Hussain, A.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Hussain, N.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Hwang, T. S.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Iftimia, N.

Izatt, J. A.

Jacques, S. L.

Jayaraman, V.

Jensen, O. B.

Jiang, J.

Jirauschek, C.

Jones, S. M.

Jonnal, R. S.

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

Jung, W.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Kamp, G.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, “In vivo optical coherence tomography,” Am. J. Ophthalmol. 116(1), 113–114 (1993).
[PubMed]

Kampik, A.

Karpf, S.

Kärtner, F. X.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

Klein, T.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “Shot-Noise Limited Time-Encoded Raman Spectroscopy,” J. Spectrosc. 2017, 9253475 (2017).

T. Klein and R. Huber, “High-speed OCT light sources and systems,” Biomed. Opt. Express 8(2), 828–859 (2017).
[PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[PubMed]

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6, 6784 (2015).
[PubMed]

W. Wieser, W. Draxinger, T. Klein, S. Karpf, T. Pfeiffer, and R. Huber, “High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s,” Biomed. Opt. Express 5(9), 2963–2977 (2014).
[PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[PubMed]

C. M. Eigenwillig, W. Wieser, S. Todor, B. R. Biedermann, T. Klein, C. Jirauschek, and R. Huber, “Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers,” Nat. Commun. 4, 1848 (2013).
[PubMed]

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt. 17, 0705051 (2012).

W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express 3(10), 2647–2657 (2012).
[PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[PubMed]

B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Direct measurement of the instantaneous linewidth of rapidly wavelength-swept lasers,” Opt. Lett. 35(22), 3733–3735 (2010).
[PubMed]

S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K.-H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express 18(15), 15820–15831 (2010).
[PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[PubMed]

Ko, T.

Kocaoglu, O. P.

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

O. P. Kocaoglu, T. L. Turner, Z. Liu, and D. T. Miller, “Adaptive optics optical coherence tomography at 1 MHz,” Biomed. Opt. Express 5(12), 4186–4200 (2014).
[PubMed]

Kolb, J. P.

Kowalczyk, A.

Kufner, C. L.

Laut, S.

Lawman, S.

Le, T.

Lee, S.-H.

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

Leitgeb, R.

Leitgeb, R. A.

Lin, C. P.

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Liu, G.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Liu, J. J.

Liu, Z.

Lu, C. D.

Ma, Z.

Makita, S.

Marschall, S.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K.-H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express 18(15), 15820–15831 (2010).
[PubMed]

Miller, D. T.

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

O. P. Kocaoglu, T. L. Turner, Z. Liu, and D. T. Miller, “Adaptive optics optical coherence tomography at 1 MHz,” Biomed. Opt. Express 5(12), 4186–4200 (2014).
[PubMed]

Milliken, J.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Morgner, U.

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

Mukai, D.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Nassif, N.

Neubauer, A.

Neubauer, A. S.

Olivier, S. S.

Otis, L.

Owen, G. M.

Palte, G.

Park, B.

Pedersen, C.

Pfeiffer, T.

Pierce, M.

Pircher, M.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

K. Wiesauer, M. Pircher, E. Götzinger, S. Bauer, R. Engelke, G. Ahrens, G. Grützner, C. Hitzenberger, and D. Stifter, “En-face scanning optical coherence tomography with ultra-high resolution for material investigation,” Opt. Express 13(3), 1015–1024 (2005).
[PubMed]

Pitris, C.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

Podoleanu, A. G.

Potsaid, B.

Puliafito, C. A.

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Querry, M. R.

Reichel, E.

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
[PubMed]

Reznicek, L.

Rolland, J. P.

Rosa, C. C.

Sadda, S.

G. Staurenghi, S. Sadda, U. Chakravarthy, R. F. Spaide, and International Nomenclature for Optical Coherence Tomography (IN•OCT) Panel, “Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN*OCT consensus,” Ophthalmology 121(8), 1572–1578 (2014).
[PubMed]

Saltzman, D.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Sasse, S.

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Sathyam, U.

Sattmann, H.

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, “In vivo optical coherence tomography,” Am. J. Ophthalmol. 116(1), 113–114 (1993).
[PubMed]

Schmitt, J. M.

Schmoll, T.

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt. 17, 0705051 (2012).

Schuman, J. S.

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[PubMed]

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Shen, Y.

Southern, J. F.

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
[PubMed]

Spaide, R. F.

G. Staurenghi, S. Sadda, U. Chakravarthy, R. F. Spaide, and International Nomenclature for Optical Coherence Tomography (IN•OCT) Panel, “Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN*OCT consensus,” Ophthalmology 121(8), 1572–1578 (2014).
[PubMed]

Srinivasan, V.

Staurenghi, G.

G. Staurenghi, S. Sadda, U. Chakravarthy, R. F. Spaide, and International Nomenclature for Optical Coherence Tomography (IN•OCT) Panel, “Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN*OCT consensus,” Ophthalmology 121(8), 1572–1578 (2014).
[PubMed]

Stifter, D.

Stingl, A.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Stroeve, P.

Su, J. P.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Sumpf, B.

Swanson, E. A.

Tearney, G.

Tearney, G. J.

B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser,” Opt. Lett. 22(22), 1704–1706 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
[PubMed]

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

Todor, S.

C. M. Eigenwillig, W. Wieser, S. Todor, B. R. Biedermann, T. Klein, C. Jirauschek, and R. Huber, “Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers,” Nat. Commun. 4, 1848 (2013).
[PubMed]

S. Todor, B. Biedermann, W. Wieser, R. Huber, and C. Jirauschek, “Instantaneous lineshape analysis of Fourier domain mode-locked lasers,” Opt. Express 19(9), 8802–8807 (2011).
[PubMed]

Torzicky, T.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

Trasischker, W.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

Trépanier, F.

Turner, T. L.

Unterhuber, A.

Verhoef, A.-J.

Wang, R. K.

Weingast, J.

Weng, D.

Werner, J. S.

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
[PubMed]

Wiesauer, K.

Wieser, W.

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “Shot-Noise Limited Time-Encoded Raman Spectroscopy,” J. Spectrosc. 2017, 9253475 (2017).

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6, 6784 (2015).
[PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[PubMed]

W. Wieser, W. Draxinger, T. Klein, S. Karpf, T. Pfeiffer, and R. Huber, “High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s,” Biomed. Opt. Express 5(9), 2963–2977 (2014).
[PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[PubMed]

C. M. Eigenwillig, W. Wieser, S. Todor, B. R. Biedermann, T. Klein, C. Jirauschek, and R. Huber, “Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers,” Nat. Commun. 4, 1848 (2013).
[PubMed]

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt. 17, 0705051 (2012).

C. Blatter, J. Weingast, A. Alex, B. Grajciar, W. Wieser, W. Drexler, R. Huber, and R. A. Leitgeb, “In situ structural and microangiographic assessment of human skin lesions with high-speed OCT,” Biomed. Opt. Express 3(10), 2636–2646 (2012).
[PubMed]

W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express 3(10), 2647–2657 (2012).
[PubMed]

C. Blatter, B. Grajciar, P. Zou, W. Wieser, A.-J. Verhoef, R. Huber, and R. A. Leitgeb, “Intrasweep phase-sensitive optical coherence tomography for noncontact optical photoacoustic imaging,” Opt. Lett. 37(21), 4368–4370 (2012).
[PubMed]

W. Wieser, G. Palte, C. M. Eigenwillig, B. R. Biedermann, T. Pfeiffer, and R. Huber, “Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools,” Opt. Express 20(9), 9819–9832 (2012).
[PubMed]

S. Todor, B. Biedermann, W. Wieser, R. Huber, and C. Jirauschek, “Instantaneous lineshape analysis of Fourier domain mode-locked lasers,” Opt. Express 19(9), 8802–8807 (2011).
[PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[PubMed]

B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Direct measurement of the instantaneous linewidth of rapidly wavelength-swept lasers,” Opt. Lett. 35(22), 3733–3735 (2010).
[PubMed]

S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K.-H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express 18(15), 15820–15831 (2010).
[PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[PubMed]

Williams, B. M.

Wojtkowski, M.

Yadlowsky, M. J.

J. M. Schmitt, M. J. Yadlowsky, and R. F. Bonner, “Subsurface imaging of living skin with optical coherence microscopy,” Dermatology (Basel) 191(2), 93–98 (1995).
[PubMed]

Yamanari, M.

Yasuno, Y.

Yatagai, T.

Yun, S.

Yun, S.-H.

Zawadzki, R. J.

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
[PubMed]

Zhang, J.

Zhang, M.

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Zhang, Z.

Zhao, M.

Zheng, Y.

Zotter, S.

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

Zou, P.

Am. J. Gastroenterol. (1)

G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, S. A. Boppart, and J. G. Fujimoto, “Optical biopsy in human gastrointestinal tissue using optical coherence tomography,” Am. J. Gastroenterol. 92(10), 1800–1804 (1997).
[PubMed]

Am. J. Ophthalmol. (1)

A. F. Fercher, C. K. Hitzenberger, W. Drexler, G. Kamp, and H. Sattmann, “In vivo optical coherence tomography,” Am. J. Ophthalmol. 116(1), 113–114 (1993).
[PubMed]

Appl. Opt. (2)

Biomed. Opt. Express (11)

W. Wieser, T. Klein, D. C. Adler, F. Trépanier, C. M. Eigenwillig, S. Karpf, J. M. Schmitt, and R. Huber, “Extended coherence length megahertz FDML and its application for anterior segment imaging,” Biomed. Opt. Express 3(10), 2647–2657 (2012).
[PubMed]

T. Klein and R. Huber, “High-speed OCT light sources and systems,” Biomed. Opt. Express 8(2), 828–859 (2017).
[PubMed]

C. Jirauschek and R. Huber, “Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers,” Biomed. Opt. Express 6(7), 2448–2465 (2015).
[PubMed]

C. Blatter, J. Weingast, A. Alex, B. Grajciar, W. Wieser, W. Drexler, R. Huber, and R. A. Leitgeb, “In situ structural and microangiographic assessment of human skin lesions with high-speed OCT,” Biomed. Opt. Express 3(10), 2636–2646 (2012).
[PubMed]

M. Eibl, S. Karpf, D. Weng, H. Hakert, T. Pfeiffer, J. P. Kolb, and R. Huber, “Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate,” Biomed. Opt. Express 8(7), 3132–3142 (2017).
[PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[PubMed]

W. Wieser, W. Draxinger, T. Klein, S. Karpf, T. Pfeiffer, and R. Huber, “High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s,” Biomed. Opt. Express 5(9), 2963–2977 (2014).
[PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[PubMed]

E. A. Swanson and J. G. Fujimoto, “The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact Invited,” Biomed. Opt. Express 8(3), 1638–1664 (2017).
[PubMed]

O. P. Kocaoglu, T. L. Turner, Z. Liu, and D. T. Miller, “Adaptive optics optical coherence tomography at 1 MHz,” Biomed. Opt. Express 5(12), 4186–4200 (2014).
[PubMed]

Dermatology (Basel) (1)

J. M. Schmitt, M. J. Yadlowsky, and R. F. Bonner, “Subsurface imaging of living skin with optical coherence microscopy,” Dermatology (Basel) 191(2), 93–98 (1995).
[PubMed]

Int J Retina Vitreous (1)

N. Hussain, A. Hussain, M. Zhang, J. P. Su, G. Liu, T. S. Hwang, S. T. Bailey, and D. Huang, “Diametric measurement of foveal avascular zone in healthy young adults using Optical Coherence Tomography Angiography,” Int J Retina Vitreous 2(OCT), 27–36 (2016).
[PubMed]

Invest. Ophthalmol. Vis. Sci. (1)

R. S. Jonnal, O. P. Kocaoglu, R. J. Zawadzki, S.-H. Lee, J. S. Werner, and D. T. Miller, “The Cellular Origins of the Outer Retinal Bands in Optical Coherence Tomography Images,” Invest. Ophthalmol. Vis. Sci. 55(12), 7904–7918 (2014).
[PubMed]

J. Biomed. Opt. (2)

C. Blatter, T. Klein, B. Grajciar, T. Schmoll, W. Wieser, R. Andre, R. Huber, and R. A. Leitgeb, “Ultrahigh-speed non-invasive widefield angiography,” J. Biomed. Opt. 17, 0705051 (2012).

T. Torzicky, S. Marschall, M. Pircher, B. Baumann, M. Bonesi, S. Zotter, E. Goetzinger, W. Trasischker, T. Klein, W. Wieser, B. Biedermann, R. Huber, P. Andersen, and C. K. Hitzenberger, “Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser,” J. Biomed. Opt. 18, 026008 (2013).

J. Opt. Soc. Am. B (1)

J. Spectrosc. (1)

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “Shot-Noise Limited Time-Encoded Raman Spectroscopy,” J. Spectrosc. 2017, 9253475 (2017).

J. Thorac. Cardiovasc. Surg. (1)

N. Hanna, D. Saltzman, D. Mukai, Z. Chen, S. Sasse, J. Milliken, S. Guo, W. Jung, H. Colt, and M. Brenner, “Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura,” J. Thorac. Cardiovasc. Surg. 129(3), 615–622 (2005).
[PubMed]

Nat. Commun. (2)

C. M. Eigenwillig, W. Wieser, S. Todor, B. R. Biedermann, T. Klein, C. Jirauschek, and R. Huber, “Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers,” Nat. Commun. 4, 1848 (2013).
[PubMed]

S. Karpf, M. Eibl, W. Wieser, T. Klein, and R. Huber, “A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy,” Nat. Commun. 6, 6784 (2015).
[PubMed]

Nat. Med. (1)

W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, “Ultrahigh-resolution ophthalmic optical coherence tomography,” Nat. Med. 7(4), 502–507 (2001).
[PubMed]

Ophthalmology (2)

C. A. Puliafito, M. R. Hee, C. P. Lin, E. Reichel, J. S. Schuman, J. S. Duker, J. A. Izatt, E. A. Swanson, and J. G. Fujimoto, “Imaging of macular diseases with optical coherence tomography,” Ophthalmology 102(2), 217–229 (1995).
[PubMed]

G. Staurenghi, S. Sadda, U. Chakravarthy, R. F. Spaide, and International Nomenclature for Optical Coherence Tomography (IN•OCT) Panel, “Proposed lexicon for anatomic landmarks in normal posterior segment spectral-domain optical coherence tomography: the IN*OCT consensus,” Ophthalmology 121(8), 1572–1578 (2014).
[PubMed]

Opt. Express (18)

S. Marschall, T. Klein, W. Wieser, B. R. Biedermann, K. Hsu, K. P. Hansen, B. Sumpf, K.-H. Hasler, G. Erbert, O. B. Jensen, C. Pedersen, R. Huber, and P. E. Andersen, “Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier,” Opt. Express 18(15), 15820–15831 (2010).
[PubMed]

R. Huber, M. Wojtkowski, and J. G. Fujimoto, “Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography,” Opt. Express 14(8), 3225–3237 (2006).
[PubMed]

W. Wieser, G. Palte, C. M. Eigenwillig, B. R. Biedermann, T. Pfeiffer, and R. Huber, “Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools,” Opt. Express 20(9), 9819–9832 (2012).
[PubMed]

B. Cense, N. Nassif, T. Chen, M. Pierce, S.-H. Yun, B. Park, B. Bouma, G. Tearney, and J. de Boer, “Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography,” Opt. Express 12(11), 2435–2447 (2004).
[PubMed]

S. Makita, Y. Hong, M. Yamanari, T. Yatagai, and Y. Yasuno, “Optical coherence angiography,” Opt. Express 14(17), 7821–7840 (2006).
[PubMed]

R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express 15(7), 4083–4097 (2007).
[PubMed]

B. Colston, U. Sathyam, L. Dasilva, M. Everett, P. Stroeve, and L. Otis, “Dental OCT,” Opt. Express 3(6), 230–238 (1998).
[PubMed]

K. Wiesauer, M. Pircher, E. Götzinger, S. Bauer, R. Engelke, G. Ahrens, G. Grützner, C. Hitzenberger, and D. Stifter, “En-face scanning optical coherence tomography with ultra-high resolution for material investigation,” Opt. Express 13(3), 1015–1024 (2005).
[PubMed]

J. Zhang, B. M. Williams, S. Lawman, D. Atkinson, Z. Zhang, Y. Shen, and Y. Zheng, “Non-destructive analysis of flake properties in automotive paints with full-field optical coherence tomography and 3D segmentation,” Opt. Express 25(16), 18614–18628 (2017).
[PubMed]

R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, “Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging,” Opt. Express 13(21), 8532–8546 (2005).
[PubMed]

S. Yun, G. Tearney, J. de Boer, N. Iftimia, and B. Bouma, “High-speed optical frequency-domain imaging,” Opt. Express 11(22), 2953–2963 (2003).
[PubMed]

M. Wojtkowski, V. Srinivasan, T. Ko, J. Fujimoto, A. Kowalczyk, and J. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express 12(11), 2404–2422 (2004).
[PubMed]

R. Leitgeb, W. Drexler, A. Unterhuber, B. Hermann, T. Bajraszewski, T. Le, A. Stingl, and A. Fercher, “Ultrahigh resolution Fourier domain optical coherence tomography,” Opt. Express 12(10), 2156–2165 (2004).
[PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[PubMed]

S. Todor, B. Biedermann, W. Wieser, R. Huber, and C. Jirauschek, “Instantaneous lineshape analysis of Fourier domain mode-locked lasers,” Opt. Express 19(9), 8802–8807 (2011).
[PubMed]

C. Jirauschek, B. Biedermann, and R. Huber, “A theoretical description of Fourier domain mode locked lasers,” Opt. Express 17(26), 24013–24019 (2009).
[PubMed]

Opt. Lett. (9)

B. R. Biedermann, W. Wieser, C. M. Eigenwillig, T. Klein, and R. Huber, “Direct measurement of the instantaneous linewidth of rapidly wavelength-swept lasers,” Opt. Lett. 35(22), 3733–3735 (2010).
[PubMed]

C. Jirauschek and R. Huber, “Modeling and analysis of polarization effects in Fourier domain mode-locked lasers,” Opt. Lett. 40(10), 2385–2388 (2015).
[PubMed]

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett. 22(5), 340–342 (1997).
[PubMed]

B. Golubovic, B. E. Bouma, G. J. Tearney, and J. G. Fujimoto, “Optical frequency-domain reflectometry using rapid wavelength tuning of a Cr4+:forsterite laser,” Opt. Lett. 22(22), 1704–1706 (1997).
[PubMed]

J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical Coherence Microscopy in Scattering Media,” Opt. Lett. 19(8), 590–592 (1994).
[PubMed]

E. A. Swanson, J. A. Izatt, M. R. Hee, D. Huang, C. P. Lin, J. S. Schuman, C. A. Puliafito, and J. G. Fujimoto, “In vivo retinal imaging by optical coherence tomography,” Opt. Lett. 18(21), 1864–1866 (1993).
[PubMed]

C. Blatter, B. Grajciar, P. Zou, W. Wieser, A.-J. Verhoef, R. Huber, and R. A. Leitgeb, “Intrasweep phase-sensitive optical coherence tomography for noncontact optical photoacoustic imaging,” Opt. Lett. 37(21), 4368–4370 (2012).
[PubMed]

R. Huber, D. C. Adler, and J. G. Fujimoto, “Buffered Fourier domain mode locking: Unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s,” Opt. Lett. 31(20), 2975–2977 (2006).
[PubMed]

A. C. Akcay, J. P. Rolland, and J. M. Eichenholz, “Spectral shaping to improve the point spread function in optical coherence tomography,” Opt. Lett. 28(20), 1921–1923 (2003).
[PubMed]

Science (2)

G. J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276(5321), 2037–2039 (1997).
[PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[PubMed]

Other (5)

W. Drexler and J. G. Fujimoto, Optical coherence tomography: technology and applications (Springer, 2008).

J. P. Kolb, J. Klee, T. Pfeiffer, and R. Huber, “1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full eye length and retinal ultra-widefield OCT,” in European Conferences on Biomedical Optics, (International Society for Optics and Photonics, 2017), 104160J–104160J–104166.

T. Pfeiffer, W. Draxinger, W. Wieser, T. Klein, and R. Huber, “Analysis of FDML lasers with meter range coherence,” in SPIE BiOS, (SPIE, 2017), 100531T.

J. P. Kolb, T. Klein, W. Wieser, W. Draxinger, and R. Huber, “Full volumetric video rate OCT of the posterior eye with up to 195.2 volumes/s,” in 2015), 931202–931202–931207.

E. F. Maher, “Transmission and absorption coefficients for ocular media of the rhesus monkey,” (School of Aerospace Medicine Brooks AFB TX, 1978).

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Figures (7)

Figure 1
Figure 1 Overview of imaging speed versus axial resolution for different research and commercial systems with flying spot approaches. TD-OCT, SD-OCT and SS-OCT systems are color-coded. Data from commercial systems are obtained from manufacturer’s websites. Research systems are [20, 21, 23, 24, 31].
Fig. 2
Fig. 2 A) Setup of the employed FDML laser. LDC: Laser diode controller; AWG: Arbitrary waveform generator; OSA: Optical spectrum analyzer; PD: Photodiode; PC: Polarization controller; cFBG: Chirped fiber-Bragg grating, ISO: Optical isolator; BFP-TP: Tunable Fabry-Perot Filter, SOA: Semiconductor optical amplifier. B) Spectrum achieved with 417 kHz FDML and with 1.67 MHz FDML. The 120 nm spectrum was attenuated for better visualization.
Fig. 3
Fig. 3 Point spread function of a mirror imaged at 800 µm depth. Zoom-in shows the FFT together with a Gaussian fit. The FWHM in air is 7.4 µm.
Fig. 4
Fig. 4 Top row shows spectra measured A) directly after the FDML laser, B) after the booster SOA and before the photodetector after passing 4 cm of water. The bottom row shows the Fourier-transform of each spectrum together with the FWHM in tissue.
Fig. 5
Fig. 5 Roll-off measurement of the FDML laser with 120 nm bandwidth and 1.67 MHz sweep rate. The amplitude of the FFT decreased by 6 dB after 1.5 mm.
Fig. 6
Fig. 6 Representative B-scan of the OCT imaging with 120 nm and 70 nm sweeping bandwidth and a four times flying average. An area around the RPE and around the top retinal layer is magnified in the blue and red boxes.
Fig. 7
Fig. 7 Comparison of our OCT imaging with 5.9 µm axial resolution with the highest resolving ophthalmic flying spot OCT images to date [21].

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