Abstract

Space-division multiplexing optical coherence tomography (SDM-OCT) is a recently developed parallel OCT imaging method in order to achieve multi-fold speed improvement. However, the assembly of fiber optics components used in the first prototype system was labor-intensive and susceptible to errors. Here, we demonstrate a high-speed SDM-OCT system using an integrated photonic chip that can be reliably manufactured with high precisions and low per-unit cost. A three-layer cascade of 1 × 2 splitters was integrated in the photonic chip to split the incident light into 8 parallel imaging channels with ~3.7 mm optical delay in air between each channel. High-speed imaging (~1s/volume) of porcine eyes ex vivo and wide-field imaging (~18.0 × 14.3 mm2) of human fingers in vivo were demonstrated with the chip-based SDM-OCT system.

© 2017 Optical Society of America

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2017 (1)

2016 (8)

J. Fujimoto and E. Swanson, “The Development, Commercialization, and Impact of Optical Coherence TomographyHistory of Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 57, 1–13 (2016).
[PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

S. Song, J. Xu, and R. K. Wang, “Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source,” Biomed. Opt. Express 7(11), 4734–4748 (2016).
[Crossref] [PubMed]

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

W. Chen, J. You, X. Gu, C. Du, and Y. Pan, “High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging,” Sci. Rep. 6(1), 38786 (2016).
[Crossref] [PubMed]

L. Chang, N. Weiss, T. G. van Leeuwen, M. Pollnau, R. M. de Ridder, K. Wörhoff, V. Subramaniam, and J. S. Kanger, “Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm,” Opt. Express 24(12), 12635–12650 (2016).
[Crossref] [PubMed]

Z. Wang, B. Potsaid, L. Chen, C. Doerr, H.-C. Lee, T. Nielson, V. Jayaraman, A. E. Cable, E. Swanson, and J. G. Fujimoto, “Cubic meter volume optical coherence tomography,” Optica 3(12), 1496–1503 (2016).
[Crossref] [PubMed]

2015 (6)

L. Duan, T. Marvdashti, and A. K. Ellerbee, “Polarization-sensitive interleaved optical coherence tomography,” Opt. Express 23(10), 13693–13703 (2015).
[Crossref] [PubMed]

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

E. Min, J. Lee, A. Vavilin, S. Jung, S. Shin, J. Kim, and W. Jung, “Wide-field optical coherence microscopy of the mouse brain slice,” Opt. Lett. 40(19), 4420–4423 (2015).
[Crossref] [PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[Crossref] [PubMed]

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

T. Wang, T. Pfeiffer, E. Regar, W. Wieser, H. van Beusekom, C. T. Lancee, G. Springeling, I. Krabbendam, A. F. W. van der Steen, R. Huber, and G. van Soest, “Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography,” Biomed. Opt. Express 6(12), 5021–5032 (2015).
[Crossref] [PubMed]

2014 (10)

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, “Optical coherence tomography today: speed, contrast, and multimodality,” J. Biomed. Opt. 19(7), 071412 (2014).
[Crossref] [PubMed]

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

C. Jun, M. Villiger, W.-Y. Oh, and B. E. Bouma, “All-fiber wavelength swept ring laser based on Fabry-Perot filter for optical frequency domain imaging,” Opt. Express 22(21), 25805–25814 (2014).
[Crossref] [PubMed]

M. Bonesi, M. P. Minneman, J. Ensher, B. Zabihian, H. Sattmann, P. Boschert, E. Hoover, R. A. Leitgeb, M. Crawford, and W. Drexler, “Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length,” Opt. Express 22(3), 2632–2655 (2014).
[Crossref] [PubMed]

H. Y. Lee, T. Marvdashti, L. Duan, S. A. Khan, and A. K. Ellerbee, “Scalable multiplexing for parallel imaging with interleaved optical coherence tomography,” Biomed. Opt. Express 5(9), 3192–3203 (2014).
[Crossref] [PubMed]

L. Duan, H. Y. Lee, G. Lee, M. Agrawal, G. T. Smith, and A. K. Ellerbee, “Single-shot speckle noise reduction by interleaved optical coherence tomography,” J. Biomed. Opt. 19(12), 120501 (2014).
[Crossref] [PubMed]

G. Yurtsever, B. Považay, A. Alex, B. Zabihian, W. Drexler, and R. Baets, “Photonic integrated Mach-Zehnder interferometer with an on-chip reference arm for optical coherence tomography,” Biomed. Opt. Express 5(4), 1050–1061 (2014).
[Crossref] [PubMed]

G. Yurtsever, N. Weiss, J. Kalkman, T. G. van Leeuwen, and R. Baets, “Ultra-compact silicon photonic integrated interferometer for swept-source optical coherence tomography,” Opt. Lett. 39(17), 5228–5231 (2014).
[Crossref] [PubMed]

2013 (8)

O. O. Ahsen, Y. K. Tao, B. M. Potsaid, Y. Sheikine, J. Jiang, I. Grulkowski, T.-H. Tsai, V. Jayaraman, M. F. Kraus, J. L. Connolly, J. Hornegger, A. Cable, and J. G. Fujimoto, “Swept source optical coherence microscopy using a 1310 nm VCSEL light source,” Opt. Express 21(15), 18021–18033 (2013).
[Crossref] [PubMed]

C. Zhou, A. Alex, J. Rasakanthan, and Y. Ma, “Space-division multiplexing optical coherence tomography,” Opt. Express 21(16), 19219–19227 (2013).
[Crossref] [PubMed]

C. Blatter, S. Coquoz, B. Grajciar, A. S. G. Singh, M. Bonesi, R. M. Werkmeister, L. Schmetterer, and R. A. Leitgeb, “Dove prism based rotating dual beam bidirectional Doppler OCT,” Biomed. Opt. Express 4(7), 1188–1203 (2013).
[Crossref] [PubMed]

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
[Crossref] [PubMed]

H. Y. Lee, H. Sudkamp, T. Marvdashti, and A. K. Ellerbee, “Interleaved optical coherence tomography,” Opt. Express 21(22), 26542–26556 (2013).
[Crossref] [PubMed]

H. C. Hendargo, R. Estrada, S. J. Chiu, C. Tomasi, S. Farsiu, and J. A. Izatt, “Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography,” Biomed. Opt. Express 4(6), 803–821 (2013).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

2012 (2)

2011 (3)

2010 (3)

2009 (3)

2006 (1)

W. Buehl, D. Stojanac, S. Sacu, W. Drexler, and O. Findl, “Comparison of three methods of measuring corneal thickness and anterior chamber depth,” Am. J. Ophthalmol. 141(1), 7–12 (2006).
[Crossref] [PubMed]

2005 (1)

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300 nm ring laser source,” J. Biomed. Opt. 10, 044009 (2005).

2003 (3)

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Agrawal, M.

L. Duan, H. Y. Lee, G. Lee, M. Agrawal, G. T. Smith, and A. K. Ellerbee, “Single-shot speckle noise reduction by interleaved optical coherence tomography,” J. Biomed. Opt. 19(12), 120501 (2014).
[Crossref] [PubMed]

Ahsen, O. O.

Alex, A.

An, L.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Antoine, M.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Assayag, O.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Baets, R.

Baran, U.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

Barry, S.

Baumann, B.

Biedermann, B. R.

Bird, A. C.

Blatter, C.

Boccara, C.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Bock, R.

Bonesi, M.

Boschert, P.

Boudoux, C.

Bouma, B. E.

Buehl, W.

W. Buehl, D. Stojanac, S. Sacu, W. Drexler, and O. Findl, “Comparison of three methods of measuring corneal thickness and anterior chamber depth,” Am. J. Ophthalmol. 141(1), 7–12 (2006).
[Crossref] [PubMed]

Burcheri, A.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Cable, A.

Cable, A. E.

Z. Wang, B. Potsaid, L. Chen, C. Doerr, H.-C. Lee, T. Nielson, V. Jayaraman, A. E. Cable, E. Swanson, and J. G. Fujimoto, “Cubic meter volume optical coherence tomography,” Optica 3(12), 1496–1503 (2016).
[Crossref] [PubMed]

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[Crossref] [PubMed]

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[Crossref] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[Crossref] [PubMed]

Chang, L.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Chen, L.

Chen, W.

W. Chen, J. You, X. Gu, C. Du, and Y. Pan, “High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging,” Sci. Rep. 6(1), 38786 (2016).
[Crossref] [PubMed]

Chiu, S. J.

Choi, S. S.

Choi, W.

Choma, M.

Choma, M. A.

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300 nm ring laser source,” J. Biomed. Opt. 10, 044009 (2005).

Connolly, J. L.

Coquoz, S.

Crawford, M.

Dalimier, E.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Davis, W. O.

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

de Ridder, R. M.

Doerr, C.

Draxinger, W.

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

Drexler, W.

Du, C.

W. Chen, J. You, X. Gu, C. Du, and Y. Pan, “High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging,” Sci. Rep. 6(1), 38786 (2016).
[Crossref] [PubMed]

Duan, L.

Duker, J. S.

Egan, C. A.

Eigenwillig, C. M.

Ellerbee, A. K.

Ensher, J.

Esmaeelpour, M.

Estrada, R.

Evans, J. W.

Farsiu, S.

Fercher, A.

Findl, O.

W. Buehl, D. Stojanac, S. Sacu, W. Drexler, and O. Findl, “Comparison of three methods of measuring corneal thickness and anterior chamber depth,” Am. J. Ophthalmol. 141(1), 7–12 (2006).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fujimoto, J.

J. Fujimoto and E. Swanson, “The Development, Commercialization, and Impact of Optical Coherence TomographyHistory of Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 57, 1–13 (2016).
[PubMed]

Fujimoto, J. G.

Z. Wang, B. Potsaid, L. Chen, C. Doerr, H.-C. Lee, T. Nielson, V. Jayaraman, A. E. Cable, E. Swanson, and J. G. Fujimoto, “Cubic meter volume optical coherence tomography,” Optica 3(12), 1496–1503 (2016).
[Crossref] [PubMed]

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

O. O. Ahsen, Y. K. Tao, B. M. Potsaid, Y. Sheikine, J. Jiang, I. Grulkowski, T.-H. Tsai, V. Jayaraman, M. F. Kraus, J. L. Connolly, J. Hornegger, A. Cable, and J. G. Fujimoto, “Swept source optical coherence microscopy using a 1310 nm VCSEL light source,” Opt. Express 21(15), 18021–18033 (2013).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[Crossref] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fuller, A. R.

Gora, M.

Götzinger, E.

Grajciar, B.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Grieve, K.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Grulkowski, I.

Gu, X.

W. Chen, J. You, X. Gu, C. Du, and Y. Pan, “High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging,” Sci. Rep. 6(1), 38786 (2016).
[Crossref] [PubMed]

Hamann, B.

Haritoglou, C.

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

Harms, F.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Heim, P. J. S.

Hendargo, H. C.

Hermann, B.

Hitzenberger, C.

Hitzenberger, C. K.

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
[Crossref] [PubMed]

S. Zotter, M. Pircher, T. Torzicky, M. Bonesi, E. Götzinger, R. A. Leitgeb, and C. K. Hitzenberger, “Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography,” Opt. Express 19(2), 1217–1227 (2011).
[Crossref] [PubMed]

Hofer, B.

Hoover, E.

Hornegger, J.

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

O. O. Ahsen, Y. K. Tao, B. M. Potsaid, Y. Sheikine, J. Jiang, I. Grulkowski, T.-H. Tsai, V. Jayaraman, M. F. Kraus, J. L. Connolly, J. Hornegger, A. Cable, and J. G. Fujimoto, “Swept source optical coherence microscopy using a 1310 nm VCSEL light source,” Opt. Express 21(15), 18021–18033 (2013).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[Crossref] [PubMed]

Hsu, K.

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300 nm ring laser source,” J. Biomed. Opt. 10, 044009 (2005).

Huang, D.

Huang, Y.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Huber, R.

T. Klein and R. Huber, “High-speed OCT light sources and systems [Invited],” Biomed. Opt. Express 8(2), 828–859 (2017).
[Crossref] [PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[Crossref] [PubMed]

T. Wang, T. Pfeiffer, E. Regar, W. Wieser, H. van Beusekom, C. T. Lancee, G. Springeling, I. Krabbendam, A. F. W. van der Steen, R. Huber, and G. van Soest, “Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography,” Biomed. Opt. Express 6(12), 5021–5032 (2015).
[Crossref] [PubMed]

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[Crossref] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[Crossref] [PubMed]

M. Gora, K. Karnowski, M. Szkulmowski, B. J. Kaluzny, R. Huber, A. Kowalczyk, and M. Wojtkowski, “Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range,” Opt. Express 17(17), 14880–14894 (2009).
[Crossref] [PubMed]

Izatt, J.

Izatt, J. A.

Jayaraman, V.

Z. Wang, B. Potsaid, L. Chen, C. Doerr, H.-C. Lee, T. Nielson, V. Jayaraman, A. E. Cable, E. Swanson, and J. G. Fujimoto, “Cubic meter volume optical coherence tomography,” Optica 3(12), 1496–1503 (2016).
[Crossref] [PubMed]

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

O. O. Ahsen, Y. K. Tao, B. M. Potsaid, Y. Sheikine, J. Jiang, I. Grulkowski, T.-H. Tsai, V. Jayaraman, M. F. Kraus, J. L. Connolly, J. Hornegger, A. Cable, and J. G. Fujimoto, “Swept source optical coherence microscopy using a 1310 nm VCSEL light source,” Opt. Express 21(15), 18021–18033 (2013).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[Crossref] [PubMed]

Jiang, J.

Jun, C.

Jung, S.

Jung, W.

Kalkman, J.

Kaluzny, B. J.

Kamali, T.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, “Optical coherence tomography today: speed, contrast, and multimodality,” J. Biomed. Opt. 19(7), 071412 (2014).
[Crossref] [PubMed]

Kampik, A.

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

Kanger, J. S.

Karnowski, K.

Kernt, M.

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

Khan, S. A.

Kim, J.

Klein, T.

T. Klein and R. Huber, “High-speed OCT light sources and systems [Invited],” Biomed. Opt. Express 8(2), 828–859 (2017).
[Crossref] [PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[Crossref] [PubMed]

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[Crossref] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[Crossref] [PubMed]

Kolb, J. P.

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[Crossref] [PubMed]

Kowalczyk, A.

Krabbendam, I.

Kraus, M. F.

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

O. O. Ahsen, Y. K. Tao, B. M. Potsaid, Y. Sheikine, J. Jiang, I. Grulkowski, T.-H. Tsai, V. Jayaraman, M. F. Kraus, J. L. Connolly, J. Hornegger, A. Cable, and J. G. Fujimoto, “Swept source optical coherence microscopy using a 1310 nm VCSEL light source,” Opt. Express 21(15), 18021–18033 (2013).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[Crossref] [PubMed]

Kubach, S.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Kufner, C. L.

Kumar, A.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, “Optical coherence tomography today: speed, contrast, and multimodality,” J. Biomed. Opt. 19(7), 071412 (2014).
[Crossref] [PubMed]

Lancee, C. T.

Laron, M.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Le Conte de Poly, B.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Lee, G.

L. Duan, H. Y. Lee, G. Lee, M. Agrawal, G. T. Smith, and A. K. Ellerbee, “Single-shot speckle noise reduction by interleaved optical coherence tomography,” J. Biomed. Opt. 19(12), 120501 (2014).
[Crossref] [PubMed]

Lee, H. Y.

Lee, H.-C.

Lee, J.

Leitgeb, R.

Leitgeb, R. A.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Liu, J. J.

Liu, M.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, “Optical coherence tomography today: speed, contrast, and multimodality,” J. Biomed. Opt. 19(7), 071412 (2014).
[Crossref] [PubMed]

Lu, C. D.

Ma, Y.

Marvdashti, T.

Mashimo, H.

Mayer, M. A.

Min, E.

Minneman, M. P.

Mohler, K. J.

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

Neubauer, A.

Neubauer, A. S.

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[Crossref] [PubMed]

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

Nielson, T.

Oh, W.-Y.

Pan, Y.

W. Chen, J. You, X. Gu, C. Du, and Y. Pan, “High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging,” Sci. Rep. 6(1), 38786 (2016).
[Crossref] [PubMed]

Pfeiffer, T.

Pircher, M.

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
[Crossref] [PubMed]

S. Zotter, M. Pircher, T. Torzicky, M. Bonesi, E. Götzinger, R. A. Leitgeb, and C. K. Hitzenberger, “Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography,” Opt. Express 19(2), 1217–1227 (2011).
[Crossref] [PubMed]

Pollnau, M.

Potsaid, B.

Z. Wang, B. Potsaid, L. Chen, C. Doerr, H.-C. Lee, T. Nielson, V. Jayaraman, A. E. Cable, E. Swanson, and J. G. Fujimoto, “Cubic meter volume optical coherence tomography,” Optica 3(12), 1496–1503 (2016).
[Crossref] [PubMed]

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[Crossref] [PubMed]

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[Crossref] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[Crossref] [PubMed]

Potsaid, B. M.

Povazay, B.

Považay, B.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Qi, X.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

Qin, W.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Rasakanthan, J.

Regar, E.

Reznicek, L.

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

Riben, M.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Sacu, S.

W. Buehl, D. Stojanac, S. Sacu, W. Drexler, and O. Findl, “Comparison of three methods of measuring corneal thickness and anterior chamber depth,” Am. J. Ophthalmol. 141(1), 7–12 (2006).
[Crossref] [PubMed]

Sarunic, M.

Sattmann, H.

Schmetterer, L.

Schuman, J. S.

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Sharma, U.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Sheikine, Y.

Shin, S.

Sigal-Zafrani, B.

O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
[PubMed]

Singh, A. S. G.

Smith, G. T.

L. Duan, H. Y. Lee, G. Lee, M. Agrawal, G. T. Smith, and A. K. Ellerbee, “Single-shot speckle noise reduction by interleaved optical coherence tomography,” J. Biomed. Opt. 19(12), 120501 (2014).
[Crossref] [PubMed]

Song, S.

Springeling, G.

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Stojanac, D.

W. Buehl, D. Stojanac, S. Sacu, W. Drexler, and O. Findl, “Comparison of three methods of measuring corneal thickness and anterior chamber depth,” Am. J. Ophthalmol. 141(1), 7–12 (2006).
[Crossref] [PubMed]

Subramaniam, V.

Sudkamp, H.

Swanson, E.

J. Fujimoto and E. Swanson, “The Development, Commercialization, and Impact of Optical Coherence TomographyHistory of Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 57, 1–13 (2016).
[PubMed]

Z. Wang, B. Potsaid, L. Chen, C. Doerr, H.-C. Lee, T. Nielson, V. Jayaraman, A. E. Cable, E. Swanson, and J. G. Fujimoto, “Cubic meter volume optical coherence tomography,” Optica 3(12), 1496–1503 (2016).
[Crossref] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Szkulmowski, M.

Tao, Y. K.

Tearney, G. J.

Tomasi, C.

Torti, C.

Torzicky, T.

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
[Crossref] [PubMed]

S. Zotter, M. Pircher, T. Torzicky, M. Bonesi, E. Götzinger, R. A. Leitgeb, and C. K. Hitzenberger, “Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography,” Opt. Express 19(2), 1217–1227 (2011).
[Crossref] [PubMed]

Trasischker, W.

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
[Crossref] [PubMed]

Tsai, T.-H.

Tumlinson, A. R.

Unterhuber, A.

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, “Optical coherence tomography today: speed, contrast, and multimodality,” J. Biomed. Opt. 19(7), 071412 (2014).
[Crossref] [PubMed]

van Beusekom, H.

van der Steen, A. F. W.

van Leeuwen, T. G.

van Soest, G.

Vavilin, A.

Villiger, M.

Wang, R. K.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

S. Song, J. Xu, and R. K. Wang, “Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source,” Biomed. Opt. Express 7(11), 4734–4748 (2016).
[Crossref] [PubMed]

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Wang, T.

Wang, Z.

Wei, W.

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

Weiss, N.

Werkmeister, R. M.

C. Blatter, S. Coquoz, B. Grajciar, A. S. G. Singh, M. Bonesi, R. M. Werkmeister, L. Schmetterer, and R. A. Leitgeb, “Dove prism based rotating dual beam bidirectional Doppler OCT,” Biomed. Opt. Express 4(7), 1188–1203 (2013).
[Crossref] [PubMed]

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
[Crossref] [PubMed]

Werner, J. S.

Wieser, W.

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[Crossref] [PubMed]

T. Wang, T. Pfeiffer, E. Regar, W. Wieser, H. van Beusekom, C. T. Lancee, G. Springeling, I. Krabbendam, A. F. W. van der Steen, R. Huber, and G. van Soest, “Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography,” Biomed. Opt. Express 6(12), 5021–5032 (2015).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[Crossref] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[Crossref] [PubMed]

Wojtkowski, M.

Wolf, A.

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
[Crossref] [PubMed]

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

Wörhoff, K.

Xu, J.

S. Song, J. Xu, and R. K. Wang, “Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source,” Biomed. Opt. Express 7(11), 4734–4748 (2016).
[Crossref] [PubMed]

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Yang, C.

You, J.

W. Chen, J. You, X. Gu, C. Du, and Y. Pan, “High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging,” Sci. Rep. 6(1), 38786 (2016).
[Crossref] [PubMed]

Yun, S. H.

Yurtsever, G.

Zabihian, B.

Zawadzki, R. J.

Zhang, Q.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
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Zhang, T.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Zhou, C.

Zotter, S.

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
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S. Zotter, M. Pircher, T. Torzicky, M. Bonesi, E. Götzinger, R. A. Leitgeb, and C. K. Hitzenberger, “Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography,” Opt. Express 19(2), 1217–1227 (2011).
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Am. J. Ophthalmol. (1)

W. Buehl, D. Stojanac, S. Sacu, W. Drexler, and O. Findl, “Comparison of three methods of measuring corneal thickness and anterior chamber depth,” Am. J. Ophthalmol. 141(1), 7–12 (2006).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (15)

T. Klein and R. Huber, “High-speed OCT light sources and systems [Invited],” Biomed. Opt. Express 8(2), 828–859 (2017).
[Crossref] [PubMed]

T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H. Mashimo, A. E. Cable, and J. G. Fujimoto, “Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology,” Biomed. Opt. Express 4(7), 1119–1132 (2013).
[Crossref] [PubMed]

T. Wang, T. Pfeiffer, E. Regar, W. Wieser, H. van Beusekom, C. T. Lancee, G. Springeling, I. Krabbendam, A. F. W. van der Steen, R. Huber, and G. van Soest, “Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography,” Biomed. Opt. Express 6(12), 5021–5032 (2015).
[Crossref] [PubMed]

B. Baumann, B. Potsaid, M. F. Kraus, J. J. Liu, D. Huang, J. Hornegger, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT,” Biomed. Opt. Express 2(6), 1539–1552 (2011).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[Crossref] [PubMed]

T. Klein, W. Wieser, L. Reznicek, A. Neubauer, A. Kampik, and R. Huber, “Multi-MHz retinal OCT,” Biomed. Opt. Express 4(10), 1890–1908 (2013).
[Crossref] [PubMed]

C. D. Lu, M. F. Kraus, B. Potsaid, J. J. Liu, W. Choi, V. Jayaraman, A. E. Cable, J. Hornegger, J. S. Duker, and J. G. Fujimoto, “Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror,” Biomed. Opt. Express 5(1), 293–311 (2014).
[Crossref] [PubMed]

J. P. Kolb, T. Klein, C. L. Kufner, W. Wieser, A. S. Neubauer, and R. Huber, “Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle,” Biomed. Opt. Express 6(5), 1534–1552 (2015).
[Crossref] [PubMed]

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

S. Song, J. Xu, and R. K. Wang, “Long-range and wide field of view optical coherence tomography for in vivo 3D imaging of large volume object based on akinetic programmable swept source,” Biomed. Opt. Express 7(11), 4734–4748 (2016).
[Crossref] [PubMed]

H. C. Hendargo, R. Estrada, S. J. Chiu, C. Tomasi, S. Farsiu, and J. A. Izatt, “Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography,” Biomed. Opt. Express 4(6), 803–821 (2013).
[Crossref] [PubMed]

H. Y. Lee, T. Marvdashti, L. Duan, S. A. Khan, and A. K. Ellerbee, “Scalable multiplexing for parallel imaging with interleaved optical coherence tomography,” Biomed. Opt. Express 5(9), 3192–3203 (2014).
[Crossref] [PubMed]

C. Blatter, S. Coquoz, B. Grajciar, A. S. G. Singh, M. Bonesi, R. M. Werkmeister, L. Schmetterer, and R. A. Leitgeb, “Dove prism based rotating dual beam bidirectional Doppler OCT,” Biomed. Opt. Express 4(7), 1188–1203 (2013).
[Crossref] [PubMed]

G. Yurtsever, B. Považay, A. Alex, B. Zabihian, W. Drexler, and R. Baets, “Photonic integrated Mach-Zehnder interferometer with an on-chip reference arm for optical coherence tomography,” Biomed. Opt. Express 5(4), 1050–1061 (2014).
[Crossref] [PubMed]

Graefes Arch. Clin. Exp. Ophthalmol. (1)

L. Reznicek, T. Klein, W. Wieser, M. Kernt, A. Wolf, C. Haritoglou, A. Kampik, R. Huber, and A. S. Neubauer, “Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices,” Graefes Arch. Clin. Exp. Ophthalmol. 252(6), 1009–1016 (2014).
[Crossref] [PubMed]

Invest. Ophthalmol. Vis. Sci. (2)

K. J. Mohler, W. Draxinger, T. Klein, J. P. Kolb, W. Wieser, C. Haritoglou, A. Kampik, J. G. Fujimoto, A. S. Neubauer, R. Huber, and A. Wolf, “Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm,” Invest. Ophthalmol. Vis. Sci. 56(11), 6284–6293 (2015).
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J. Fujimoto and E. Swanson, “The Development, Commercialization, and Impact of Optical Coherence TomographyHistory of Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 57, 1–13 (2016).
[PubMed]

J. Biomed. Opt. (6)

W. Drexler, M. Liu, A. Kumar, T. Kamali, A. Unterhuber, and R. A. Leitgeb, “Optical coherence tomography today: speed, contrast, and multimodality,” J. Biomed. Opt. 19(7), 071412 (2014).
[Crossref] [PubMed]

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

M. A. Choma, K. Hsu, and J. A. Izatt, “Swept source optical coherence tomography using an all-fiber 1300 nm ring laser source,” J. Biomed. Opt. 10, 044009 (2005).

W. Trasischker, R. M. Werkmeister, S. Zotter, B. Baumann, T. Torzicky, M. Pircher, and C. K. Hitzenberger, “In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography,” J. Biomed. Opt. 18(11), 116010 (2013).
[Crossref] [PubMed]

L. Duan, H. Y. Lee, G. Lee, M. Agrawal, G. T. Smith, and A. K. Ellerbee, “Single-shot speckle noise reduction by interleaved optical coherence tomography,” J. Biomed. Opt. 19(12), 120501 (2014).
[Crossref] [PubMed]

Opt. Eng. (1)

U. Baran, W. Wei, J. Xu, X. Qi, W. O. Davis, and R. K. Wang, “Video-rate volumetric optical coherence tomography-based microangiography,” Opt. Eng. 55(4), 040503 (2016).
[Crossref]

Opt. Express (16)

M. Gora, K. Karnowski, M. Szkulmowski, B. J. Kaluzny, R. Huber, A. Kowalczyk, and M. Wojtkowski, “Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range,” Opt. Express 17(17), 14880–14894 (2009).
[Crossref] [PubMed]

M. Choma, M. Sarunic, C. Yang, and J. Izatt, “Sensitivity advantage of swept source and Fourier domain optical coherence tomography,” Opt. Express 11(18), 2183–2189 (2003).
[Crossref] [PubMed]

R. Leitgeb, C. Hitzenberger, and A. Fercher, “Performance of fourier domain vs. time domain optical coherence tomography,” Opt. Express 11(8), 889–894 (2003).
[Crossref] [PubMed]

W. Wieser, B. R. Biedermann, T. Klein, C. M. Eigenwillig, and R. Huber, “Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second,” Opt. Express 18(14), 14685–14704 (2010).
[Crossref] [PubMed]

C. Jun, M. Villiger, W.-Y. Oh, and B. E. Bouma, “All-fiber wavelength swept ring laser based on Fabry-Perot filter for optical frequency domain imaging,” Opt. Express 22(21), 25805–25814 (2014).
[Crossref] [PubMed]

M. Bonesi, M. P. Minneman, J. Ensher, B. Zabihian, H. Sattmann, P. Boschert, E. Hoover, R. A. Leitgeb, M. Crawford, and W. Drexler, “Akinetic all-semiconductor programmable swept-source at 1550 nm and 1310 nm with centimeters coherence length,” Opt. Express 22(3), 2632–2655 (2014).
[Crossref] [PubMed]

B. Potsaid, B. Baumann, D. Huang, S. Barry, A. E. Cable, J. S. Schuman, J. S. Duker, and J. G. Fujimoto, “Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second,” Opt. Express 18(19), 20029–20048 (2010).
[Crossref] [PubMed]

S. Zotter, M. Pircher, T. Torzicky, M. Bonesi, E. Götzinger, R. A. Leitgeb, and C. K. Hitzenberger, “Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography,” Opt. Express 19(2), 1217–1227 (2011).
[Crossref] [PubMed]

R. J. Zawadzki, S. S. Choi, A. R. Fuller, J. W. Evans, B. Hamann, and J. S. Werner, “Cellular resolution volumetric in vivo retinal imaging with adaptive optics-optical coherence tomography,” Opt. Express 17(5), 4084–4094 (2009).
[Crossref] [PubMed]

B. Povazay, B. Hofer, C. Torti, B. Hermann, A. R. Tumlinson, M. Esmaeelpour, C. A. Egan, A. C. Bird, and W. Drexler, “Impact of enhanced resolution, speed and penetration on three-dimensional retinal optical coherence tomography,” Opt. Express 17(5), 4134–4150 (2009).
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T. Klein, W. Wieser, C. M. Eigenwillig, B. R. Biedermann, and R. Huber, “Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser,” Opt. Express 19(4), 3044–3062 (2011).
[Crossref] [PubMed]

L. Duan, T. Marvdashti, and A. K. Ellerbee, “Polarization-sensitive interleaved optical coherence tomography,” Opt. Express 23(10), 13693–13703 (2015).
[Crossref] [PubMed]

C. Zhou, A. Alex, J. Rasakanthan, and Y. Ma, “Space-division multiplexing optical coherence tomography,” Opt. Express 21(16), 19219–19227 (2013).
[Crossref] [PubMed]

H. Y. Lee, H. Sudkamp, T. Marvdashti, and A. K. Ellerbee, “Interleaved optical coherence tomography,” Opt. Express 21(22), 26542–26556 (2013).
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L. Chang, N. Weiss, T. G. van Leeuwen, M. Pollnau, R. M. de Ridder, K. Wörhoff, V. Subramaniam, and J. S. Kanger, “Chip based common-path optical coherence tomography system with an on-chip microlens and multi-reference suppression algorithm,” Opt. Express 24(12), 12635–12650 (2016).
[Crossref] [PubMed]

O. O. Ahsen, Y. K. Tao, B. M. Potsaid, Y. Sheikine, J. Jiang, I. Grulkowski, T.-H. Tsai, V. Jayaraman, M. F. Kraus, J. L. Connolly, J. Hornegger, A. Cable, and J. G. Fujimoto, “Swept source optical coherence microscopy using a 1310 nm VCSEL light source,” Opt. Express 21(15), 18021–18033 (2013).
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Optica (1)

Sci. Rep. (1)

W. Chen, J. You, X. Gu, C. Du, and Y. Pan, “High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging,” Sci. Rep. 6(1), 38786 (2016).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
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O. Assayag, M. Antoine, B. Sigal-Zafrani, M. Riben, F. Harms, A. Burcheri, K. Grieve, E. Dalimier, B. Le Conte de Poly, and C. Boccara, “Large Field, High Resolution Full-Field Optical Coherence Tomography: A Pre-Clinical Study of Human Breast Tissue and Cancer Assessment,” Technol. Cancer Res. Treat. 13(5), 455–468 (2014).
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T. Pfeiffer, W. Draxinger, W. Wieser, T. Klein, M. Petermann, and R. Huber, “Analysis of FDML lasers with meter range coherence,” in SPIE BiOS, 100531T (2017).

K. Preston, A. Nitkowski, N. Sherwood-Droz, B. S. Schmidt, and A. R. Hajian, “On-chip spectrometer for low-cost optical coherence tomography,” Technical Proceedings of the 2014 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2014 2, 435–438 (2014).

C. Zhou, “Apparatus and Method for Space-Division Multiplexing Optical Coherence Tomography,” US 9,400,169 B2, WO 2014/088650 A1 (2014).

Supplementary Material (3)

NameDescription
» Visualization 1       3D rendering of SDM-OCT images of ex vivo porcine eye.
» Visualization 2       3D rendering of SDM-OCT images of in vivo human fingerprint.
» Visualization 3       3D rendering of SDM-OCT images of in vivo human finger nail.

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Figures (4)

Fig. 1
Fig. 1 (A) Schematic arrangement of SDM-OCT setup with an integrated photonic chip. (B) Layout of the photonic chip. Input and output of the chip was labeled. A three-layer cascade of 1 × 2 splitters were shown. Red dashed lines indicate 3 layers of 1x2 splitters, respectively. After 3 layers of splitters, the incident light was split from 1 to 8 beams. Optical delay (ΔL) was ~2.5 mm on the chip. (C) Zoom-in view of output port of the chip showing eight waveguide channels with a d = 0.25 mm spacing between them. Output channels were 8° angle polished to reduce back reflections. (D) Photograph of the chip. The chip measures 2.5 × 2.0 cm2, close to the size of a US quarter coin. (E) Roll-off measurement of the central beam of the chip-based SDM-OCT in logarithmic scale. Imaging depth range of the system was measured to be ~31.6 mm in air. A roll-off of ~2dB was observed over ~27 mm depth range in air. (F) Transverse resolution was measured to be ~20 μm with a USAF target (Group 4, element 5 is clearly visible). C: Circulator; C1, C2: collimator; DBD1, DBD2: dual balanced detectors; L1, L2, L3: lenses; M1: mirror; PC: polarization controller.
Fig. 2
Fig. 2 Chip based SDM-OCT image of ex vivo porcine eyeball of area ~13.5 × 14.3 mm2 with fast scanning protocol consists of 700 × 1200 A-scans. (A) A single 2D cross sectional B-scan (average of 10 frames) showing 8 images corresponding to 8 beams appear at different depths. Eight images cover a depth range of ~22 mm in tissue (black regions on top and bottom of the image were cropped). Different color bands at the right of the B-scan represent imaging area covered by each beam, red color shows imaging area covered by the first beam and magenta color represents the imaging area covered by the last beam. (B) 2D cross-section of final image of 8 stitched beams, color bands on the bottom show area of the image acquired by each beam. (C) Cross sectional image of the single beam cropped out of a single B-scan. (D) En face image of the final stitched image, horizontal and vertical dashed lines show the directions of 2D cross sectional images shown in (B) and (C) respectively. (E) 3D volumetric reconstruction of anterior chamber of the eyeball using final stitched image (Visualization 1).
Fig. 3
Fig. 3 Chip based SDM-OCT in vivo wide-field human fingerprint imaging of area 18.0 × 14.3 mm2 with fast scanning protocol consists of 700 × 1200 A-scans. (A) Photograph of middle finger print showing 8 beams illumination, rectangular box defines imaging area. (B) A single 2D cross sectional B-scan (average of 10 frames) showing 8 images corresponding to 8 beams appear at different depths. Different color bands at the right of the B-scan represent imaging area covered by each beam, red color shows imaging area covered by the first beam and magenta color represents the imaging area covered by the last beam. (C) 2D cross sectional image of the single beam. (D) 2D cross-section of final stitched image of 8 beams. (E) Enlarged area of the cross section of final stitched image showing sweat ducts. (F) En face view of the final stitched image, horizontal and vertical dashed lines show the directions of 2D cross sectional images shown in (C) and (D) respectively. Color bands on the left side of the image denote area of the image acquired by each beam. 3D rendering of the fingerprint image can be found in Visualization 2.
Fig. 4
Fig. 4 Chip based SDM-OCT in vivo wide-field human finger nail imaging of area 18.0 × 14.3 mm2 with high definition scanning protocol consists of 1500 × 1600 A-scans. (A) Photograph of nail side of middle finger showing 8 beams illumination, rectangular box defines imaging area. (B) A single 2D cross sectional B-scan (average of 10 frames) showing 8 images corresponding to 8 beams appear at different depths. Different color bands at the right of the B-scan represent imaging area covered by each beam, red color shows imaging area covered by the first beam and violet color represents the imaging area covered by the last beam. (C) 2D cross sectional image of the single beam. (D) 2D cross-section of final image of 8 stitched beams. (E) En face view of the final stitched image, horizontal and vertical dashed lines show the directions of 2D cross sectional images shown in (C) and (D) respectively. Color bands on the left side of the image denote area of the image acquired by each beam. 3D rendering of the finger nail image can be found in Visualization 3.

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