Abstract

High-sensitivity cardiac troponin assay development enables determination of biological variation in healthy populations, more accurate interpretation of clinical results and points towards earlier diagnosis and rule-out of acute myocardial infarction. In this paper, we report on preliminary tests of an immunoassay analyzer employing an optimized LED excitation to measure on a standard troponin I and a novel research high-sensitivity troponin I assay. The limit of detection is improved by factor of 5 for standard troponin I and by factor of 3 for a research high-sensitivity troponin I assay, compared to the flash lamp excitation. The obtained limit of detection was 0.22 ng/L measured on plasma with the research high-sensitivity troponin I assay and 1.9 ng/L measured on tris-saline-azide buffer containing bovine serum albumin with the standard troponin I assay. We discuss the optimization of time-resolved detection of lanthanide fluorescence based on the time constants of the system and analyze the background and noise sources in a heterogeneous fluoroimmunoassay. We determine the limiting factors and their impact on the measurement performance. The suggested model can be generally applied to fluoroimmunoassays employing the dry-cup concept.

© 2017 Optical Society of America

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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2017 (1)

O. Rodenko, H. Fodgaard, P. Tidemand-Lichtenberg, and C. Pedersen, “340nm UV LED excitation in time-resolved fluorescence system for europium-based immunoassays detection,” Proc. SPIE 10072, 100720M (2017).

2016 (2)

O. Rodenko, H. Fodgaard, P. Tidemand-Lichtenberg, P. M. Petersen, and C. Pedersen, “340 nm pulsed UV LED system for europium-based time-resolved fluorescence detection of immunoassays,” Opt. Express 24(19), 22135–22143 (2016).
[Crossref] [PubMed]

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
[Crossref] [PubMed]

2015 (3)

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

2014 (3)

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
[Crossref] [PubMed]

S. Aldous, A. Mark Richards, P. M. George, L. Cullen, W. A. Parsonage, D. Flaws, C. M. Florkowski, R. W. Troughton, J. W. O’Sullivan, C. M. Reid, L. Bannister, and M. Than, “Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction,” Int. J. Cardiol. 177(1), 182–186 (2014).
[Crossref] [PubMed]

S. W. Kettlitz, C. Moosmann, S. Valouch, and U. Lemmer, “Sensitivity improvement in fluorescence-based particle detection,” Cytometry A 85(9), 746–755 (2014).
[Crossref] [PubMed]

2013 (1)

P. M. McKie, D. M. Heublein, C. G. Scott, M. L. Gantzer, R. A. Mehta, R. J. Rodeheffer, M. M. Redfield, J. C. Burnett, and A. S. Jaffe, “Defining high-sensitivity cardiac troponin concentrations in the community,” Clin. Chem. 59(7), 1099–1107 (2013).
[Crossref] [PubMed]

2012 (3)

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

F. S. Apple, P. O. Collinson, and IFCC Task Force on Clinical Applications of Cardiac Biomarkers, “Analytical characteristics of high-sensitivity cardiac troponin assays,” Clin. Chem. 58(1), 54–61 (2012).
[Crossref] [PubMed]

R. Twerenbold, A. Jaffe, T. Reichlin, M. Reiter, and C. Mueller, “High-sensitive troponin T measurements: what do we gain and what are the challenges?” Eur. Heart J. 33(5), 579–586 (2012).
[Crossref] [PubMed]

2011 (2)

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

S. Hjortshøj, P. Venge, and J. Ravkilde, “Clinical performance of a new point-of-care cardiac troponin I assay compared to three laboratory troponin assays,” Clin. Chim. Acta 412(3-4), 370–375 (2011).
[Crossref] [PubMed]

2010 (2)

J.-C. G. Bünzli, “Lanthanide luminescence for biomedical analyses and imaging,” Chem. Rev. 110(5), 2729–2755 (2010).
[Crossref] [PubMed]

N. Gahlaut and L. W. Miller, “Time-Resolved Microscopy for Imaging Lanthanide Luminescence in Living Cells,” Cytometry A 77(12), 1113–1125 (2010).
[Crossref] [PubMed]

2009 (1)

P. Hedberg and G. Wennecke, “A preliminary evaluation of the AQT90 FLEX TnI immunoassay,” Clin. Chem. Lab. Med. 47(3), 376–378 (2009).
[Crossref] [PubMed]

2007 (1)

D. Jin, R. Connally, and J. Piper, “Practical time-gated luminescence flow cytometry. II: Experimental evaluation using UV LED excitation,” Cytometry A 71(10), 797–808 (2007).
[Crossref] [PubMed]

2006 (1)

R. Connally, D. Jin, and J. Piper, “High Intensity Solid-State UV Source for Time-Gated Luminescence Microscopy,” Cytometry A 69(9), 1020–1027 (2006).
[Crossref] [PubMed]

2005 (3)

P. von Lode, “Point-of-care immunotesting: Approaching the analytical performance of central laboratory methods,” Clin. Biochem. 38(7), 591–606 (2005).
[Crossref] [PubMed]

I. Hemmilä and V. Laitala, “Progress in lanthanides as luminescent probes,” J. Fluoresc. 15(4), 529–542 (2005).
[Crossref] [PubMed]

S. Eriksson, T. Ilva, C. Becker, J. Lund, P. Porela, K. Pulkki, L.-M. Voipio-Pulkki, and K. Pettersson, “Comparison of Cardiac Troponin I Immunoassays Variably Affected by Circulating Autoantibodies,” Clin. Chem. 51(5), 848–855 (2005).
[Crossref] [PubMed]

2004 (1)

R. Connally, D. Veal, and J. Piper, “Flash lamp-excited time-resolved fluorescence microscope suppresses autofluorescence in water concentrates to deliver an 11-fold increase in signal-to-noise ratio,” J. Biomed. Opt. 9(4), 725–734 (2004).
[Crossref] [PubMed]

2000 (1)

P. St-Louis, “Status of point-of-care testing: promise, realities, and possibilities,” Clin. Biochem. 33(6), 427–440 (2000).
[Crossref] [PubMed]

1996 (1)

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

1992 (1)

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
[Crossref] [PubMed]

Aldous, S.

S. Aldous, A. Mark Richards, P. M. George, L. Cullen, W. A. Parsonage, D. Flaws, C. M. Florkowski, R. W. Troughton, J. W. O’Sullivan, C. M. Reid, L. Bannister, and M. Than, “Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction,” Int. J. Cardiol. 177(1), 182–186 (2014).
[Crossref] [PubMed]

Alpert, J. S.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Antman, E. M.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Apple, F. S.

F. S. Apple, P. O. Collinson, and IFCC Task Force on Clinical Applications of Cardiac Biomarkers, “Analytical characteristics of high-sensitivity cardiac troponin assays,” Clin. Chem. 58(1), 54–61 (2012).
[Crossref] [PubMed]

Armstrong, P. W.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Arnold, C.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Atar, D.

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K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
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M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
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Keller, T.

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Kettlitz, S. W.

S. W. Kettlitz, C. Moosmann, S. Valouch, and U. Lemmer, “Sensitivity improvement in fluorescence-based particle detection,” Cytometry A 85(9), 746–755 (2014).
[Crossref] [PubMed]

Kimenai, D. M.

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
[Crossref] [PubMed]

Kojola, H.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
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Kreutzinger, P.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Krivoshei, L.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
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Kuulasmaa, K.

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
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Kuusisto, A.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
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T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Lackner, K. J.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
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Laitala, V.

I. Hemmilä and V. Laitala, “Progress in lanthanides as luminescent probes,” J. Fluoresc. 15(4), 529–542 (2005).
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Latta, D. D.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

Lemmer, U.

S. W. Kettlitz, C. Moosmann, S. Valouch, and U. Lemmer, “Sensitivity improvement in fluorescence-based particle detection,” Cytometry A 85(9), 746–755 (2014).
[Crossref] [PubMed]

Levy, D.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Lillpopp, L.

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Lindahl, B.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Lopez-Sendon, J. L.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Lorenzoni, V.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
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Lövgren, T.

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

Luepker, R. V.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Lund, J.

S. Eriksson, T. Ilva, C. Becker, J. Lund, P. Porela, K. Pulkki, L.-M. Voipio-Pulkki, and K. Pettersson, “Comparison of Cardiac Troponin I Immunoassays Variably Affected by Circulating Autoantibodies,” Clin. Chem. 51(5), 848–855 (2005).
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Mäkelä, M.

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

Mäkinen, M. L.

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

Marcucci, F.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
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Mark Richards, A.

S. Aldous, A. Mark Richards, P. M. George, L. Cullen, W. A. Parsonage, D. Flaws, C. M. Florkowski, R. W. Troughton, J. W. O’Sullivan, C. M. Reid, L. Bannister, and M. Than, “Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction,” Int. J. Cardiol. 177(1), 182–186 (2014).
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Masotti, S.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
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McKie, P. M.

P. M. McKie, D. M. Heublein, C. G. Scott, M. L. Gantzer, R. A. Mehta, R. J. Rodeheffer, M. M. Redfield, J. C. Burnett, and A. S. Jaffe, “Defining high-sensitivity cardiac troponin concentrations in the community,” Clin. Chem. 59(7), 1099–1107 (2013).
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Meex, S. J.

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
[Crossref] [PubMed]

Mehta, R. A.

P. M. McKie, D. M. Heublein, C. G. Scott, M. L. Gantzer, R. A. Mehta, R. J. Rodeheffer, M. M. Redfield, J. C. Burnett, and A. S. Jaffe, “Defining high-sensitivity cardiac troponin concentrations in the community,” Clin. Chem. 59(7), 1099–1107 (2013).
[Crossref] [PubMed]

Mele, A.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

Menasché, P.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Mendis, S.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Meriö, L.

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

Messineo, A.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

Michal, M.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

Miller, L. W.

N. Gahlaut and L. W. Miller, “Time-Resolved Microscopy for Imaging Lanthanide Luminescence in Living Cells,” Cytometry A 77(12), 1113–1125 (2010).
[Crossref] [PubMed]

Mitrunen, K.

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

Möckel, M.

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Moosmann, C.

S. W. Kettlitz, C. Moosmann, S. Valouch, and U. Lemmer, “Sensitivity improvement in fluorescence-based particle detection,” Cytometry A 85(9), 746–755 (2014).
[Crossref] [PubMed]

Moreno Weidmann, Z.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Morrow, D. A.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Mueller, C.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

R. Twerenbold, A. Jaffe, T. Reichlin, M. Reiter, and C. Mueller, “High-sensitive troponin T measurements: what do we gain and what are the challenges?” Eur. Heart J. 33(5), 579–586 (2012).
[Crossref] [PubMed]

Münzel, T.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Nelles, B.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Newby, L. K.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Nieminen, M. S.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Niens, M.

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
[Crossref] [PubMed]

O’Sullivan, J. W.

S. Aldous, A. Mark Richards, P. M. George, L. Cullen, W. A. Parsonage, D. Flaws, C. M. Florkowski, R. W. Troughton, J. W. O’Sullivan, C. M. Reid, L. Bannister, and M. Than, “Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction,” Int. J. Cardiol. 177(1), 182–186 (2014).
[Crossref] [PubMed]

Ohman, E. M.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Ojeda, F.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
[Crossref] [PubMed]

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Osswald, S.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Palenius, T.

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

Parkhomenko, A. N.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Parsonage, W. A.

S. Aldous, A. Mark Richards, P. M. George, L. Cullen, W. A. Parsonage, D. Flaws, C. M. Florkowski, R. W. Troughton, J. W. O’Sullivan, C. M. Reid, L. Bannister, and M. Than, “Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction,” Int. J. Cardiol. 177(1), 182–186 (2014).
[Crossref] [PubMed]

Passino, C.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

Pedersen, C.

O. Rodenko, H. Fodgaard, P. Tidemand-Lichtenberg, and C. Pedersen, “340nm UV LED excitation in time-resolved fluorescence system for europium-based immunoassays detection,” Proc. SPIE 10072, 100720M (2017).

O. Rodenko, H. Fodgaard, P. Tidemand-Lichtenberg, P. M. Petersen, and C. Pedersen, “340 nm pulsed UV LED system for europium-based time-resolved fluorescence detection of immunoassays,” Opt. Express 24(19), 22135–22143 (2016).
[Crossref] [PubMed]

Peetz, D.

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Peitsmeyer, P.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

Petersen, P. M.

Pettersson, K.

S. Eriksson, T. Ilva, C. Becker, J. Lund, P. Porela, K. Pulkki, L.-M. Voipio-Pulkki, and K. Pettersson, “Comparison of Cardiac Troponin I Immunoassays Variably Affected by Circulating Autoantibodies,” Clin. Chem. 51(5), 848–855 (2005).
[Crossref] [PubMed]

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
[PubMed]

Pfeiffer, N.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

Pinto, F.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Piper, J.

D. Jin, R. Connally, and J. Piper, “Practical time-gated luminescence flow cytometry. II: Experimental evaluation using UV LED excitation,” Cytometry A 71(10), 797–808 (2007).
[Crossref] [PubMed]

R. Connally, D. Jin, and J. Piper, “High Intensity Solid-State UV Source for Time-Gated Luminescence Microscopy,” Cytometry A 69(9), 1020–1027 (2006).
[Crossref] [PubMed]

R. Connally, D. Veal, and J. Piper, “Flash lamp-excited time-resolved fluorescence microscope suppresses autofluorescence in water concentrates to deliver an 11-fold increase in signal-to-noise ratio,” J. Biomed. Opt. 9(4), 725–734 (2004).
[Crossref] [PubMed]

Porela, P.

S. Eriksson, T. Ilva, C. Becker, J. Lund, P. Porela, K. Pulkki, L.-M. Voipio-Pulkki, and K. Pettersson, “Comparison of Cardiac Troponin I Immunoassays Variably Affected by Circulating Autoantibodies,” Clin. Chem. 51(5), 848–855 (2005).
[Crossref] [PubMed]

Prontera, C.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

Puelacher, C.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Pulkki, K.

S. Eriksson, T. Ilva, C. Becker, J. Lund, P. Porela, K. Pulkki, L.-M. Voipio-Pulkki, and K. Pettersson, “Comparison of Cardiac Troponin I Immunoassays Variably Affected by Circulating Autoantibodies,” Clin. Chem. 51(5), 848–855 (2005).
[Crossref] [PubMed]

Ravkilde, J.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

S. Hjortshøj, P. Venge, and J. Ravkilde, “Clinical performance of a new point-of-care cardiac troponin I assay compared to three laboratory troponin assays,” Clin. Chim. Acta 412(3-4), 370–375 (2011).
[Crossref] [PubMed]

Redfield, M. M.

P. M. McKie, D. M. Heublein, C. G. Scott, M. L. Gantzer, R. A. Mehta, R. J. Rodeheffer, M. M. Redfield, J. C. Burnett, and A. S. Jaffe, “Defining high-sensitivity cardiac troponin concentrations in the community,” Clin. Chem. 59(7), 1099–1107 (2013).
[Crossref] [PubMed]

Reichlin, T.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

R. Twerenbold, A. Jaffe, T. Reichlin, M. Reiter, and C. Mueller, “High-sensitive troponin T measurements: what do we gain and what are the challenges?” Eur. Heart J. 33(5), 579–586 (2012).
[Crossref] [PubMed]

Reid, C. M.

S. Aldous, A. Mark Richards, P. M. George, L. Cullen, W. A. Parsonage, D. Flaws, C. M. Florkowski, R. W. Troughton, J. W. O’Sullivan, C. M. Reid, L. Bannister, and M. Than, “Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction,” Int. J. Cardiol. 177(1), 182–186 (2014).
[Crossref] [PubMed]

Reiter, M.

R. Twerenbold, A. Jaffe, T. Reichlin, M. Reiter, and C. Mueller, “High-sensitive troponin T measurements: what do we gain and what are the challenges?” Eur. Heart J. 33(5), 579–586 (2012).
[Crossref] [PubMed]

Rentsch, K.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Robertson, R. M.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Rodeheffer, R. J.

P. M. McKie, D. M. Heublein, C. G. Scott, M. L. Gantzer, R. A. Mehta, R. J. Rodeheffer, M. M. Redfield, J. C. Burnett, and A. S. Jaffe, “Defining high-sensitivity cardiac troponin concentrations in the community,” Clin. Chem. 59(7), 1099–1107 (2013).
[Crossref] [PubMed]

Rodenko, O.

O. Rodenko, H. Fodgaard, P. Tidemand-Lichtenberg, and C. Pedersen, “340nm UV LED excitation in time-resolved fluorescence system for europium-based immunoassays detection,” Proc. SPIE 10072, 100720M (2017).

O. Rodenko, H. Fodgaard, P. Tidemand-Lichtenberg, P. M. Petersen, and C. Pedersen, “340 nm pulsed UV LED system for europium-based time-resolved fluorescence detection of immunoassays,” Opt. Express 24(19), 22135–22143 (2016).
[Crossref] [PubMed]

Rosamond, W. D.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Saarela, O.

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
[Crossref] [PubMed]

Salo, J.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
[Crossref] [PubMed]

Salomaa, V.

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
[Crossref] [PubMed]

Sandberg, M.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
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Schaerli, N.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
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Schaper, N. C.

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
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Schnabel, R. B.

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
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Schram, M. T.

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
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Scott, C. G.

P. M. McKie, D. M. Heublein, C. G. Scott, M. L. Gantzer, R. A. Mehta, R. J. Rodeheffer, M. M. Redfield, J. C. Burnett, and A. S. Jaffe, “Defining high-sensitivity cardiac troponin concentrations in the community,” Clin. Chem. 59(7), 1099–1107 (2013).
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D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
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Seveus, L.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
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Simoons, M. L.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Sinning, C.

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
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Smith, S. C.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Soini, E.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
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Steg, P. G.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Stehouwer, C. D.

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
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Stelzig, C.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
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P. St-Louis, “Status of point-of-care testing: promise, realities, and possibilities,” Clin. Biochem. 33(6), 427–440 (2000).
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Struthers, A.

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
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Surace, P.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
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Syrjänen, S.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
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Tanglay, Y.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
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Tendera, M.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
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T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
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Turchetti, G.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
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Twerenbold, R.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
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T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
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K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Väisälä, M.

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
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D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
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D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
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Vasilieva, E. J.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
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Venge, P.

S. Hjortshøj, P. Venge, and J. Ravkilde, “Clinical performance of a new point-of-care cardiac troponin I assay compared to three laboratory troponin assays,” Clin. Chim. Acta 412(3-4), 370–375 (2011).
[Crossref] [PubMed]

Voipio-Pulkki, L.-M.

S. Eriksson, T. Ilva, C. Becker, J. Lund, P. Porela, K. Pulkki, L.-M. Voipio-Pulkki, and K. Pettersson, “Comparison of Cardiac Troponin I Immunoassays Variably Affected by Circulating Autoantibodies,” Clin. Chem. 51(5), 848–855 (2005).
[Crossref] [PubMed]

von Lode, P.

P. von Lode, “Point-of-care immunotesting: Approaching the analytical performance of central laboratory methods,” Clin. Biochem. 38(7), 591–606 (2005).
[Crossref] [PubMed]

Wallentin, L. C.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Warnholtz, A.

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Weaver, D.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Wennecke, G.

P. Hedberg and G. Wennecke, “A preliminary evaluation of the AQT90 FLEX TnI immunoassay,” Clin. Chem. Lab. Med. 47(3), 376–378 (2009).
[Crossref] [PubMed]

White, H. D.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Wijns, W.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Wild, P.

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Wild, P. S.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

Wildi, K.

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Wood, D.

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

Woodward, M.

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
[Crossref] [PubMed]

Zeller, T.

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
[Crossref] [PubMed]

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
[Crossref] [PubMed]

Zuin, M.

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

Chem. Rev. (1)

J.-C. G. Bünzli, “Lanthanide luminescence for biomedical analyses and imaging,” Chem. Rev. 110(5), 2729–2755 (2010).
[Crossref] [PubMed]

Circulation (2)

K. Thygesen, J. S. Alpert, A. S. Jaffe, M. L. Simoons, B. R. Chaitman, H. D. White, H. A. Katus, B. Lindahl, D. A. Morrow, P. M. Clemmensen, P. Johanson, H. Hod, R. Underwood, J. J. Bax, R. O. Bonow, F. Pinto, R. J. Gibbons, K. A. Fox, D. Atar, L. K. Newby, M. Galvani, C. W. Hamm, B. F. Uretsky, P. G. Steg, W. Wijns, J. P. Bassand, P. Menasché, J. Ravkilde, E. M. Ohman, E. M. Antman, L. C. Wallentin, P. W. Armstrong, M. L. Simoons, J. L. Januzzi, M. S. Nieminen, M. Gheorghiade, G. Filippatos, R. V. Luepker, S. P. Fortmann, W. D. Rosamond, D. Levy, D. Wood, S. C. Smith, D. Hu, J. L. Lopez-Sendon, R. M. Robertson, D. Weaver, M. Tendera, A. A. Bove, A. N. Parkhomenko, E. J. Vasilieva, S. Mendis, and Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction, “Third universal definition of myocardial infarction,” Circulation 126(16), 2020–2035 (2012).
[Crossref] [PubMed]

K. Wildi, M. R. Gimenez, R. Twerenbold, T. Reichlin, C. Jaeger, A. Heinzelmann, C. Arnold, B. Nelles, S. Druey, P. Haaf, P. Hillinger, N. Schaerli, P. Kreutzinger, Y. Tanglay, T. Herrmann, Z. Moreno Weidmann, L. Krivoshei, M. Freese, C. Stelzig, C. Puelacher, K. Rentsch, S. Osswald, and C. Mueller, “Misdiagnosis of myocardial infarction related to limitations of the current regulatory approach to define clinical decision values for cardiac troponin,” Circulation 131(23), 2032–2040 (2015).
[Crossref] [PubMed]

Clin. Biochem. (2)

P. St-Louis, “Status of point-of-care testing: promise, realities, and possibilities,” Clin. Biochem. 33(6), 427–440 (2000).
[Crossref] [PubMed]

P. von Lode, “Point-of-care immunotesting: Approaching the analytical performance of central laboratory methods,” Clin. Biochem. 38(7), 591–606 (2005).
[Crossref] [PubMed]

Clin. Chem. (4)

F. S. Apple, P. O. Collinson, and IFCC Task Force on Clinical Applications of Cardiac Biomarkers, “Analytical characteristics of high-sensitivity cardiac troponin assays,” Clin. Chem. 58(1), 54–61 (2012).
[Crossref] [PubMed]

P. M. McKie, D. M. Heublein, C. G. Scott, M. L. Gantzer, R. A. Mehta, R. J. Rodeheffer, M. M. Redfield, J. C. Burnett, and A. S. Jaffe, “Defining high-sensitivity cardiac troponin concentrations in the community,” Clin. Chem. 59(7), 1099–1107 (2013).
[Crossref] [PubMed]

T. Lövgren, L. Meriö, K. Mitrunen, M. L. Mäkinen, M. Mäkelä, K. Blomberg, T. Palenius, and K. Pettersson, “One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry,” Clin. Chem. 42(8 Pt 1), 1196–1201 (1996).
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S. Eriksson, T. Ilva, C. Becker, J. Lund, P. Porela, K. Pulkki, L.-M. Voipio-Pulkki, and K. Pettersson, “Comparison of Cardiac Troponin I Immunoassays Variably Affected by Circulating Autoantibodies,” Clin. Chem. 51(5), 848–855 (2005).
[Crossref] [PubMed]

Clin. Chem. Lab. Med. (2)

P. Hedberg and G. Wennecke, “A preliminary evaluation of the AQT90 FLEX TnI immunoassay,” Clin. Chem. Lab. Med. 47(3), 376–378 (2009).
[Crossref] [PubMed]

T. Zeller, F. Ojeda, F. J. Brunner, P. Peitsmeyer, T. Münzel, H. Binder, N. Pfeiffer, M. Michal, P. S. Wild, S. Blankenberg, and K. J. Lackner, “High-sensitivity cardiac troponin I in the general population-defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study,” Clin. Chem. Lab. Med. 53(5), 699–706 (2015).
[Crossref] [PubMed]

Clin. Chim. Acta (2)

M. Franzini, V. Lorenzoni, S. Masotti, C. Prontera, D. Chiappino, D. D. Latta, M. Daves, I. Deluggi, M. Zuin, L. Ferrigno, A. Mele, F. Marcucci, C. A. Caserta, P. Surace, A. Messineo, G. Turchetti, C. Passino, M. Emdin, and A. Clerico, “The calculation of the cardiac troponin T 99th percentile of the reference population is affected by age, gender, and population selection: A multicenter study in Italy,” Clin. Chim. Acta 438, 376–381 (2015).
[Crossref] [PubMed]

S. Hjortshøj, P. Venge, and J. Ravkilde, “Clinical performance of a new point-of-care cardiac troponin I assay compared to three laboratory troponin assays,” Clin. Chim. Acta 412(3-4), 370–375 (2011).
[Crossref] [PubMed]

Cytometry (1)

L. Seveus, M. Väisälä, S. Syrjänen, M. Sandberg, A. Kuusisto, R. Harju, J. Salo, I. Hemmilä, H. Kojola, and E. Soini, “Time-Resolved Fluorescence Imaging of Europium Chelate Label in Immunohistochemistry and In Situ Hybridization,” Cytometry 13(4), 329–338 (1992).
[Crossref] [PubMed]

Cytometry A (4)

S. W. Kettlitz, C. Moosmann, S. Valouch, and U. Lemmer, “Sensitivity improvement in fluorescence-based particle detection,” Cytometry A 85(9), 746–755 (2014).
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D. Jin, R. Connally, and J. Piper, “Practical time-gated luminescence flow cytometry. II: Experimental evaluation using UV LED excitation,” Cytometry A 71(10), 797–808 (2007).
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R. Connally, D. Jin, and J. Piper, “High Intensity Solid-State UV Source for Time-Gated Luminescence Microscopy,” Cytometry A 69(9), 1020–1027 (2006).
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Eur. Heart J. (2)

R. Twerenbold, A. Jaffe, T. Reichlin, M. Reiter, and C. Mueller, “High-sensitive troponin T measurements: what do we gain and what are the challenges?” Eur. Heart J. 33(5), 579–586 (2012).
[Crossref] [PubMed]

T. Zeller, H. Tunstall-Pedoe, O. Saarela, F. Ojeda, R. B. Schnabel, T. Tuovinen, M. Woodward, A. Struthers, M. Hughes, F. Kee, V. Salomaa, K. Kuulasmaa, S. Blankenberg, and MORGAM Investigators, “High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort,” Eur. Heart J. 35(5), 271–281 (2014).
[Crossref] [PubMed]

Heart (1)

D. M. Kimenai, R. M. Henry, C. J. van der Kallen, P. C. Dagnelie, M. T. Schram, C. D. Stehouwer, J. D. van Suijlen, M. Niens, O. Bekers, S. J. Sep, N. C. Schaper, M. P. van Dieijen-Visser, and S. J. Meex, “Direct comparison of clinical decision limits for cardiac troponin T and I,” Heart 102(8), 610–616 (2016).
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Int. J. Cardiol. (1)

S. Aldous, A. Mark Richards, P. M. George, L. Cullen, W. A. Parsonage, D. Flaws, C. M. Florkowski, R. W. Troughton, J. W. O’Sullivan, C. M. Reid, L. Bannister, and M. Than, “Comparison of new point-of-care troponin assay with high sensitivity troponin in diagnosing myocardial infarction,” Int. J. Cardiol. 177(1), 182–186 (2014).
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J. Biomed. Opt. (1)

R. Connally, D. Veal, and J. Piper, “Flash lamp-excited time-resolved fluorescence microscope suppresses autofluorescence in water concentrates to deliver an 11-fold increase in signal-to-noise ratio,” J. Biomed. Opt. 9(4), 725–734 (2004).
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J. Fluoresc. (1)

I. Hemmilä and V. Laitala, “Progress in lanthanides as luminescent probes,” J. Fluoresc. 15(4), 529–542 (2005).
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JAMA (1)

T. Keller, T. Zeller, F. Ojeda, S. Tzikas, L. Lillpopp, C. Sinning, P. Wild, S. Genth-Zotz, A. Warnholtz, E. Giannitsis, M. Möckel, C. Bickel, D. Peetz, K. Lackner, S. Baldus, T. Münzel, and S. Blankenberg, “Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction,” JAMA 306(24), 2684–2693 (2011).
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Opt. Express (1)

Proc. SPIE (1)

O. Rodenko, H. Fodgaard, P. Tidemand-Lichtenberg, and C. Pedersen, “340nm UV LED excitation in time-resolved fluorescence system for europium-based immunoassays detection,” Proc. SPIE 10072, 100720M (2017).

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CLSI, “Evaluation of Detection Capability for Clinical Laboratory Measurement Procedures; Approved Guideline−Second Edition,” CLSI document EP17–A2, Wayne, PA: Clinical and Laboratory Standards Institute (2012).

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Figures (8)

Fig. 1
Fig. 1 Left: an LED image is formed in the bottom of a test cup which is 6.7 mm in diameter. The 4x4 mm2 LED image takes up 45% of the cup area. Right: normalized emission spectra of the LED (blue), filtered flash lamp (red) and normalized excitation spectra of the standard TnI (yellow) and the research high-sensitivity TnI assays (green).
Fig. 2
Fig. 2 Fluorescence signal of 16 replicates measured on Instrument 2 for the flash lamp based analyzer (baseline measurement) and with the optimized LED based unit: for blank cups (processed with AQT90 FLEX assay buffer) and BSA-TSA buffer containing 30 ng/L TnI. The fluorescence signal at the concentration of 30 ng/L has increased by 25% whereas the background (concentration 0 ng/L) dropped by 26%.
Fig. 3
Fig. 3 SNR (left) and CV (right) of the five LED based instruments measured on TnI assay.
Fig. 4
Fig. 4 CV vs. concentration measured on BSA-TSA samples (left) and plasma samples (right) with the LED based analyzer and the AQT90 FLEX analyzer (flash lamp based instrument) with the research hsTnI assay.
Fig. 5
Fig. 5 Fluorescence decays of empty cup (red), blank cup (green), and cup processed with the sample of 0.25 ng/L with the hsTnI assay (blue).
Fig. 6
Fig. 6 SNR calculated for four LED based instruments measured on BSA-TSA samples with a TnI concentration of 0.25 ng/L as a function of the timing parameters: t1 as pre-delay time (i.e. time after the end of the excitation pulse before the measurement), and t2 as duration of the measurement time window.
Fig. 7
Fig. 7 SNR calculated for four LED based instruments with currently employed settings with the pre-delay time of 400 µs and the measurement window duration of 400 µs, measured on BSA-TSA samples with the novel hsTnI assay. Black star points represent average value for the LED based instruments measured on the standard TnI assay.
Fig. 8
Fig. 8 LoD calculated for four LED based instruments as a function of the pre-delay time t1 and duration of the measurement time window t2.

Tables (6)

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Table 1 Relative change of the averaged fluorescence signal of sample cups with a concentration of 30 ng/L and blank cups, after the flash lamp OUs were replaced by the optimized LED based OUs measured with the TnI assay

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Table 2 LoB, LoD and LoQ of the five LED based instruments measured on BSA-TSA buffer based TnI samples with TnI assay compared to the current state-of-the art flash lamp based instrument

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Table 3 Samples used in the hsTnI assay measurements

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Table 4 LoB and LoD measured with the LED based instrument and the flash lamp based instrument (AQT90 FLEX) on the hsTnI assay

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Table 5 Fluorescence decay lifetime constants of an empty cup and BSA-TSA samples with a TnI concentration of 0 ng/L (blank cup), 0.25 ng/L and 30 ng/L obtained by curve fitting for replicates measured on one instrument

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Table 6 Statistical data measured on four instruments with the hsTnI assay

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

L o B = μ B + 1.645 1 1 4 ( B K ) σ B
L o D = L o B + 1.645 1 1 4 ( L J ) i = 1 J ( n i 1 ) σ i 2 i = 1 J ( n i 1 )
B t o t a l = B O U + B c u p + B c h e m + B d a r k
N = N s . s h o t + N b . s h o t + N c + N l + N i

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