Abstract

Polarization imaging has been recognized as a potentially powerful technique for probing the microstructural information and optical properties of complex biological specimens. Recently, we have reported a Mueller matrix microscope by adding the polarization state generator and analyzer (PSG and PSA) to a commercial transmission-light microscope, and applied it to differentiate human liver and cervical cancerous tissues with fibrosis. In this paper, we apply the Mueller matrix microscope for quantitative detection of human breast ductal carcinoma samples at different stages. The Mueller matrix polar decomposition and transformation parameters of the breast ductal tissues in different regions and at different stages are calculated and analyzed. For more quantitative comparisons, several widely-used image texture feature parameters are also calculated to characterize the difference in the polarimetric images. The experimental results indicate that the Mueller matrix microscope and the polarization parameters can facilitate the quantitative detection of breast ductal carcinoma tissues at different stages.

© 2017 Optical Society of America

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2017 (1)

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

2016 (5)

A. Golaraei, L. Kontenis, R. Cisek, D. Tokarz, S. J. Done, B. C. Wilson, and V. Barzda, “Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy,” Biomed. Opt. Express 7(10), 4054–4068 (2016).
[Crossref] [PubMed]

J. Qi and D. S. Elson, “A high definition Mueller polarimetric endoscope for tissue characterisation,” Sci. Rep. 6(1), 25953 (2016).
[Crossref] [PubMed]

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
[Crossref] [PubMed]

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
[Crossref] [PubMed]

H. He, J. Chang, C. He, and H. Ma, “Transformation of full 4×4 Mueller matrices: a quantitative technique for biomedical diagnosis,” Proc. SPIE 9707, 97070K (2016).

2015 (3)

Y. Wang, H. He, J. Chang, N. Zeng, S. Liu, M. Li, and H. Ma, “Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope,” Micron 79, 8–15 (2015).
[Crossref] [PubMed]

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

S. Alali and A. Vitkin, “Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment,” J. Biomed. Opt. 20(6), 061104 (2015).
[Crossref] [PubMed]

2014 (6)

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

R. Siegel, J. Ma, Z. Zou, and A. Jemal, “Cancer statistics, 2014,” CA Cancer J. Clin. 64(1), 9–29 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

J. Jagtap, S. Chandel, N. Das, J. Soni, S. Chatterjee, A. Pradhan, and N. Ghosh, “Quantitative Mueller matrix fluorescence spectroscopy for precancer detection,” Opt. Lett. 39(2), 243–246 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

2013 (2)

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

2012 (1)

K. Burke, P. Tang, and E. Brown, “Second harmonic generation reveals matrix alterations during breast tumor progression,” J. Biomed. Opt. 18(3), 031106 (2012).
[Crossref] [PubMed]

2011 (1)

N. Ghosh and I. A. Vitkin, “Tissue polarimetry: concepts, challenges, applications, and outlook,” J. Biomed. Opt. 16(11), 110801 (2011).
[Crossref] [PubMed]

2010 (2)

H. He, N. Zeng, R. Liao, T. Yun, W. Li, Y. He, and H. Ma, “Application of sphere-cylinder scattering model to skeletal muscle,” Opt. Express 18(14), 15104–15112 (2010).
[Crossref] [PubMed]

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

2009 (1)

2008 (2)

N. Ghosh, M. F. Wood, and I. A. Vitkin, “Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence,” J. Biomed. Opt. 13(4), 044036 (2008).
[Crossref] [PubMed]

B. Saikia, K. Gupta, and U. N. Saikia, “The modern histopathologist: in the changing face of time,” Diagn. Pathol. 3(1), 25–29 (2008).
[Crossref] [PubMed]

2007 (1)

A. Jemal, E. Ward, and M. J. Thun, “Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women,” Breast Cancer Res. 9(3), R28 (2007).
[Crossref] [PubMed]

2004 (1)

D. B. Strader, T. Wright, D. L. Thomas, and L. B. Seeff, “Diagnosis, management, and treatment of hepatitis C,” Hepatology 39(4), 1147–1171 (2004).
[Crossref] [PubMed]

2003 (1)

National Comprehensive Cancer Network, “Breast cancer Clinical Practice Guidelines in Oncology,” J. Natl. Compr. Canc. Netw. 1(2), 148–188 (2003).
[Crossref] [PubMed]

2001 (2)

D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Estimating the world cancer burden: Globocan 2000,” Int. J. Cancer 94(2), 153–156 (2001).
[Crossref] [PubMed]

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

2000 (1)

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

1996 (1)

1992 (1)

1990 (1)

1978 (1)

1973 (1)

R. M. Haralick, K. Shanmugam, and I. H. Dinstein, “Textural Features for Image Classification,” IEEE Trans. Syst. Man Cy. 3(6), 610–621 (1973).
[Crossref]

Alali, S.

S. Alali and A. Vitkin, “Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment,” J. Biomed. Opt. 20(6), 061104 (2015).
[Crossref] [PubMed]

Allemani, C.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Antonelli, M. R.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

Arendt, J. T.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Azzam, R. M. A.

Backman, V.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Badizadegan, K.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Barzda, V.

Benali, A.

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

Blas, M. M.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Bonner, R. F.

Bouma, B. E.

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
[Crossref] [PubMed]

Bray, F.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Estimating the world cancer burden: Globocan 2000,” Int. J. Cancer 94(2), 153–156 (2001).
[Crossref] [PubMed]

Brown, E.

K. Burke, P. Tang, and E. Brown, “Second harmonic generation reveals matrix alterations during breast tumor progression,” J. Biomed. Opt. 18(3), 031106 (2012).
[Crossref] [PubMed]

Burke, K.

K. Burke, P. Tang, and E. Brown, “Second harmonic generation reveals matrix alterations during breast tumor progression,” J. Biomed. Opt. 18(3), 031106 (2012).
[Crossref] [PubMed]

Chandel, S.

Chang, J.

H. He, J. Chang, C. He, and H. Ma, “Transformation of full 4×4 Mueller matrices: a quantitative technique for biomedical diagnosis,” Proc. SPIE 9707, 97070K (2016).

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
[Crossref] [PubMed]

Y. Wang, H. He, J. Chang, N. Zeng, S. Liu, M. Li, and H. Ma, “Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope,” Micron 79, 8–15 (2015).
[Crossref] [PubMed]

Chatterjee, S.

Chipman, R. A.

Chuttani, R.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
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Cisek, R.

Cohen, H.

Coleman, M. P.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Conteh, L.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Crawford, J. M.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
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Das, N.

Dasari, R. R.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
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V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
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A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
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R. M. Haralick, K. Shanmugam, and I. H. Dinstein, “Textural Features for Image Classification,” IEEE Trans. Syst. Man Cy. 3(6), 610–621 (1973).
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Done, S. J.

Doronin, A.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
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Du, E.

Dvaladze, A.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Eccles, M.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
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J. Qi and D. S. Elson, “A high definition Mueller polarimetric endoscope for tissue characterisation,” Sci. Rep. 6(1), 25953 (2016).
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O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
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A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
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R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
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V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
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D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Estimating the world cancer burden: Globocan 2000,” Int. J. Cancer 94(2), 153–156 (2001).
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V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
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Gandjbakhche, A. H.

Gayet, B.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
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Georgakoudi, I.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
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Ghosh, N.

J. Jagtap, S. Chandel, N. Das, J. Soni, S. Chatterjee, A. Pradhan, and N. Ghosh, “Quantitative Mueller matrix fluorescence spectroscopy for precancer detection,” Opt. Lett. 39(2), 243–246 (2014).
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N. Ghosh and I. A. Vitkin, “Tissue polarimetry: concepts, challenges, applications, and outlook,” J. Biomed. Opt. 16(11), 110801 (2011).
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N. Ghosh, M. F. Wood, and I. A. Vitkin, “Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence,” J. Biomed. Opt. 13(4), 044036 (2008).
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Ginsburg, O.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Golaraei, A.

Goldsmith, J. D.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
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Goldstein, D. H.

Gralow, J.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
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Gupta, K.

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Gurjar, R. S.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
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L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
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R. M. Haralick, K. Shanmugam, and I. H. Dinstein, “Textural Features for Image Classification,” IEEE Trans. Syst. Man Cy. 3(6), 610–621 (1973).
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H. He, J. Chang, C. He, and H. Ma, “Transformation of full 4×4 Mueller matrices: a quantitative technique for biomedical diagnosis,” Proc. SPIE 9707, 97070K (2016).

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
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He, H.

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
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H. He, J. Chang, C. He, and H. Ma, “Transformation of full 4×4 Mueller matrices: a quantitative technique for biomedical diagnosis,” Proc. SPIE 9707, 97070K (2016).

Y. Wang, H. He, J. Chang, N. Zeng, S. Liu, M. Li, and H. Ma, “Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope,” Micron 79, 8–15 (2015).
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E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
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Huong, T. T.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Ibrahim, B. H.

Itani, S.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
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Itzkan, I.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
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Jacques, S.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
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Jemal, A.

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V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
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Kassami, N.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Kirk, R. W.

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
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Kline, E.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
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Kombe, D.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Kontenis, L.

Kotha, S. R.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Krishnan, S.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
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Kunnen, B.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Levin, H. S.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Leyden, J.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Li, M.

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
[Crossref] [PubMed]

Y. Wang, H. He, J. Chang, N. Zeng, S. Liu, M. Li, and H. Ma, “Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope,” Micron 79, 8–15 (2015).
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Li, W.

Liao, R.

Lim, L. G.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
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Liu, Q.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
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Liu, S.

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
[Crossref] [PubMed]

Y. Wang, H. He, J. Chang, N. Zeng, S. Liu, M. Li, and H. Ma, “Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope,” Micron 79, 8–15 (2015).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

Lorenser, D.

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
[Crossref] [PubMed]

Lu, S. Y.

Ma, H.

H. He, J. Chang, C. He, and H. Ma, “Transformation of full 4×4 Mueller matrices: a quantitative technique for biomedical diagnosis,” Proc. SPIE 9707, 97070K (2016).

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
[Crossref] [PubMed]

Y. Wang, H. He, J. Chang, N. Zeng, S. Liu, M. Li, and H. Ma, “Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope,” Micron 79, 8–15 (2015).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

H. He, N. Zeng, R. Liao, T. Yun, W. Li, Y. He, and H. Ma, “Application of sphere-cylinder scattering model to skeletal muscle,” Opt. Express 18(14), 15104–15112 (2010).
[Crossref] [PubMed]

Ma, J.

R. Siegel, J. Ma, Z. Zou, and A. Jemal, “Cancer statistics, 2014,” CA Cancer J. Clin. 64(1), 9–29 (2014).
[Crossref] [PubMed]

Macdonald, C.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Manhas, S.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

Martino, A. D.

McGilligan, J. A.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

McLaughlin, R. A.

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
[Crossref] [PubMed]

Meglinski, I.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Modell, M. D.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Müller, M. G.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Nazac, A.

Novikova, T.

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

Oomman, N.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Ozden, N.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Parham, G.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Parkin, D. M.

D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Estimating the world cancer burden: Globocan 2000,” Int. J. Cancer 94(2), 153–156 (2001).
[Crossref] [PubMed]

Peng, C.

Perelman, L. T.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Pierangelo, A.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

Pisani, P.

D. M. Parkin, F. Bray, J. Ferlay, and P. Pisani, “Estimating the world cancer burden: Globocan 2000,” Int. J. Cancer 94(2), 153–156 (2001).
[Crossref] [PubMed]

Pleskow, D. K.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Pradhan, A.

Qi, J.

J. Qi and D. S. Elson, “A high definition Mueller polarimetric endoscope for tissue characterisation,” Sci. Rep. 6(1), 25953 (2016).
[Crossref] [PubMed]

Qiu, L.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Quirk, B. C.

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
[Crossref] [PubMed]

Sacks, A.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
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Saikia, B.

B. Saikia, K. Gupta, and U. N. Saikia, “The modern histopathologist: in the changing face of time,” Diagn. Pathol. 3(1), 25–29 (2008).
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Saikia, U. N.

B. Saikia, K. Gupta, and U. N. Saikia, “The modern histopathologist: in the changing face of time,” Diagn. Pathol. 3(1), 25–29 (2008).
[Crossref] [PubMed]

Sampson, D. D.

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
[Crossref] [PubMed]

Sarker, M.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Schmitt, J. M.

Seeff, L. B.

D. B. Strader, T. Wright, D. L. Thomas, and L. B. Seeff, “Diagnosis, management, and treatment of hepatitis C,” Hepatology 39(4), 1147–1171 (2004).
[Crossref] [PubMed]

Seiler, M.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Shabbir, A.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Shanmugam, K.

R. M. Haralick, K. Shanmugam, and I. H. Dinstein, “Textural Features for Image Classification,” IEEE Trans. Syst. Man Cy. 3(6), 610–621 (1973).
[Crossref]

Shapshay, S.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Shukla, P.

Siegel, R.

R. Siegel, J. Ma, Z. Zou, and A. Jemal, “Cancer statistics, 2014,” CA Cancer J. Clin. 64(1), 9–29 (2014).
[Crossref] [PubMed]

Soni, J.

Srivastava, S.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Strader, D. B.

D. B. Strader, T. Wright, D. L. Thomas, and L. B. Seeff, “Diagnosis, management, and treatment of hepatitis C,” Hepatology 39(4), 1147–1171 (2004).
[Crossref] [PubMed]

Sullivan, R.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Sun, M.

Tang, P.

K. Burke, P. Tang, and E. Brown, “Second harmonic generation reveals matrix alterations during breast tumor progression,” J. Biomed. Opt. 18(3), 031106 (2012).
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Taylor, C.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Thomas, D. L.

D. B. Strader, T. Wright, D. L. Thomas, and L. B. Seeff, “Diagnosis, management, and treatment of hepatitis C,” Hepatology 39(4), 1147–1171 (2004).
[Crossref] [PubMed]

Thun, M. J.

A. Jemal, E. Ward, and M. J. Thun, “Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women,” Breast Cancer Res. 9(3), R28 (2007).
[Crossref] [PubMed]

Tokarz, D.

Totobenazara, J. L.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

Valdez, T.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Validire, P.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

Van Dam, J.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Vanderpuye, V.

O. Ginsburg, F. Bray, M. P. Coleman, V. Vanderpuye, A. Eniu, S. R. Kotha, M. Sarker, T. T. Huong, C. Allemani, A. Dvaladze, J. Gralow, K. Yeates, C. Taylor, N. Oomman, S. Krishnan, R. Sullivan, D. Kombe, M. M. Blas, G. Parham, N. Kassami, and L. Conteh, “The global burden of women’s cancers: a grand challenge in global health,” Lancet 389(10071), 847–860 (2017).
[Crossref] [PubMed]

Villiger, M.

M. Villiger, D. Lorenser, R. A. McLaughlin, B. C. Quirk, R. W. Kirk, B. E. Bouma, and D. D. Sampson, “Deep tissue volume imaging of birefringence through delineation of breast tumor,” Sci. Rep. 6, 28771 (2016).
[Crossref] [PubMed]

Vitkin, A.

S. Alali and A. Vitkin, “Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment,” J. Biomed. Opt. 20(6), 061104 (2015).
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Vitkin, E.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
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Vitkin, I. A.

N. Ghosh and I. A. Vitkin, “Tissue polarimetry: concepts, challenges, applications, and outlook,” J. Biomed. Opt. 16(11), 110801 (2011).
[Crossref] [PubMed]

N. Ghosh, M. F. Wood, and I. A. Vitkin, “Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence,” J. Biomed. Opt. 13(4), 044036 (2008).
[Crossref] [PubMed]

Wallace, M. B.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Wang, W.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Wang, Y.

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
[Crossref] [PubMed]

Y. Wang, H. He, J. Chang, N. Zeng, S. Liu, M. Li, and H. Ma, “Differentiating characteristic microstructural features of cancerous tissues using Mueller matrix microscope,” Micron 79, 8–15 (2015).
[Crossref] [PubMed]

Ward, E.

A. Jemal, E. Ward, and M. J. Thun, “Recent trends in breast cancer incidence rates by age and tumor characteristics among U.S. women,” Breast Cancer Res. 9(3), R28 (2007).
[Crossref] [PubMed]

Wilson, B. C.

Wood, M. F.

N. Ghosh, M. F. Wood, and I. A. Vitkin, “Mueller matrix decomposition for extraction of individual polarization parameters from complex turbid media exhibiting multiple scattering, optical activity, and linear birefringence,” J. Biomed. Opt. 13(4), 044036 (2008).
[Crossref] [PubMed]

Wright, T.

D. B. Strader, T. Wright, D. L. Thomas, and L. B. Seeff, “Diagnosis, management, and treatment of hepatitis C,” Hepatology 39(4), 1147–1171 (2004).
[Crossref] [PubMed]

Wu, J.

Y. Wang, H. He, J. Chang, C. He, S. Liu, M. Li, N. Zeng, J. Wu, and H. Ma, “Mueller matrix microscope: a quantitative tool to facilitate detections and fibrosis scorings of liver cirrhosis and cancer tissues,” J. Biomed. Opt. 21(7), 071112 (2016).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
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Yan, J. S.

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Figures (8)

Fig. 1
Fig. 1

Photograph and schematic of the Mueller matrix microscope. P: polarizer; R: quarter-wave plate; PSG: polarization state generator; PSA: polarization state analyzer.

Fig. 2
Fig. 2

Microscopic intensity images of the H and E stained slices of breast ductal tissues at different pathological stages: (a1), (b1) samples 1 and 2 in stage 1 respectively; (c1), (d1) samples 3 and 4 in stage 2 respectively; (e1), (f1) samples 5 and 6 in stage 3 respectively, and the corresponding 12-µm-thick unstained dewaxed slices of breast ductal tissues: (a2), (b2) samples 1 and 2 in stage 1 respectively, (c2), (d2) samples 3 and 4 in stage 2 respectively, (e2), (f2) samples 5 and 6 in stage 3 respectively.

Fig. 3
Fig. 3

Images of MMPD and MMT parameters of the 12-µm-thick unstained dewaxed slices of normal breast ductal tissue in stage 1: (a) sample 1; (b) sample 2.

Fig. 4
Fig. 4

Images of MMPD and MMT parameters of the 12-µm-thick unstained dewaxed slices of breast ductal carcinoma in situ for stage 2: (a) sample 3; (b) sample 4.

Fig. 5
Fig. 5

Images of MMPD and MMT parameters of the 12-µm-thick unstained dewaxed slices of breast invasive ductal carcinoma tissue in stage 3: (a) sample 5; (b) sample 6. Black arrows indicate the areas within the ducts.

Fig. 6
Fig. 6

Duct areas (in the first and third row) and non-duct areas (in the second and fourth row) of sample 1-6 were separated based on parameter δ for further quantitative characterization and analysis: (a), (b) stage 1 (samples 1&2); (c), (d) stage 2 (samples 3&4); (e), (f) stage 3 (samples 5&6).

Fig. 7
Fig. 7

Gray image segmentation results of breast ductal tissues in different pathological stages based on parameter θ: (a), (b) stage 1 (samples 1&2); (c), (d) stage 2 (samples 3&4); (e), (f) stage 3 (samples 5&6). Corresponding statistical distribution histograms of θ are provided under the gray image segmentation results.

Fig. 8
Fig. 8

Image texture parameters for duct and non-duct areas of 18 samples in different stages (6 samples for each stage): (a) M, Ct and Er of parameter δ, (b) S, Ct and Cr of parameters θ. P is the P-value between the two sets of experimental data in different stages, which is obtained by the significance test method in statistics (P < 0.05 is significant).

Equations (3)

Equations on this page are rendered with MathJax. Learn more.

I= α 0 + n=1 12 ( α n cosnωt+ β n sinnωt )
M= M Δ M R M D δ= cos 1 { [ ( M R ( 2,2 )+ M R ( 3,3 ) ) 2 + ( M R ( 3,2 )+ M R ( 2,3 ) ) 2 ] 1 2 1 } θ=0.5 tan 1 ( r 2 r 1 )
t= ( m42 ) 2 + ( m34 ) 2 2 tan(2x)= m42 m34

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