Abstract

We reported an initial clinical study of in vivo human thyroid by a photoacoustic/ultrasound handheld probe. Our dual-modality system is based on a high-end clinical ultrasound machine. Both healthy and cancerous thyroids were imaged non-invasively, and we compared the photoacoustic imaging with color Doppler ultrasound. The results of photoacoustic thyroid imaging could reveal many blood vessels that were not sensitive for Doppler ultrasound. Our study demonstrated that photoacoustic imaging could provide important complementary information for traditional ultrasound thyroid examination, which has a great potential for clinical diagnosis.

© 2017 Optical Society of America

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2016 (4)

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

A. Dima and V. Ntziachristos, “In-vivo handheld optoacoustic tomography of the human thyroid,” Photoacoustics 4(2), 65–69 (2016).
[Crossref] [PubMed]

2015 (2)

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

2014 (1)

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

2013 (2)

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

2012 (2)

2011 (2)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt. 16(2), 026004 (2011).
[Crossref] [PubMed]

2010 (1)

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

2009 (3)

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

S. Guth, U. Theune, J. Aberle, A. Galach, and C. M. Bamberger, “Very high prevalence of thyroid nodules detected by high frequency (13MHz) ultrasound examination,” N. Engl. J. Med. 351, 699–706 (2009).

2006 (1)

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

2005 (1)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

2004 (2)

L. Hegedüs, “Clinical practice. The thyroid nodule,” N. Engl. J. Med. 351(17), 1764–1771 (2004).
[Crossref] [PubMed]

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Aberle, J.

S. Guth, U. Theune, J. Aberle, A. Galach, and C. M. Bamberger, “Very high prevalence of thyroid nodules detected by high frequency (13MHz) ultrasound examination,” N. Engl. J. Med. 351, 699–706 (2009).

Alexander, E. K.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Ambartsoumian, G.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Appleton, C.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Bamberger, C. M.

S. Guth, U. Theune, J. Aberle, A. Galach, and C. M. Bamberger, “Very high prevalence of thyroid nodules detected by high frequency (13MHz) ultrasound examination,” N. Engl. J. Med. 351, 699–706 (2009).

Beard, P.

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

Bible, K. C.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Brecht, H. P.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

Brewer, M. A.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Buehler, A.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

Conjusteau, A.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Cooper, D. S.

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Cornelius, L. A.

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt. 16(2), 026004 (2011).
[Crossref] [PubMed]

Del Rio, S. P.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

Dima, A.

A. Dima and V. Ntziachristos, “In-vivo handheld optoacoustic tomography of the human thyroid,” Photoacoustics 4(2), 65–69 (2016).
[Crossref] [PubMed]

Doherty, G. M.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Duick, D. S.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

Ermilov, S. A.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Ermolayev, V.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

Erpelding, T. N.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Favazza, C. P.

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt. 16(2), 026004 (2011).
[Crossref] [PubMed]

Frenz, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Fronheiser, M. P.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

Galach, A.

S. Guth, U. Theune, J. Aberle, A. Galach, and C. M. Bamberger, “Very high prevalence of thyroid nodules detected by high frequency (13MHz) ultrasound examination,” N. Engl. J. Med. 351, 699–706 (2009).

Gambhir, S. S.

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

Garber, J. R.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

Garcia-Uribe, A.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Gateau, J.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

Gharib, H.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

Guth, S.

S. Guth, U. Theune, J. Aberle, A. Galach, and C. M. Bamberger, “Very high prevalence of thyroid nodules detected by high frequency (13MHz) ultrasound examination,” N. Engl. J. Med. 351, 699–706 (2009).

Harrell, R. M.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

Haugen, B. R.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Hegedüs, L.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

L. Hegedüs, “Clinical practice. The thyroid nodule,” N. Engl. J. Med. 351(17), 1764–1771 (2004).
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Heijblom, M.

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Jaeger, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Ke, H.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Klaase, J. M.

Kloos, R. T.

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Kruger, R. A.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

Krumholz, A.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Kuchment, P.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Kueck, A.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Kumavor, P. D.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Kuzmiak, C. M.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Lam, R. B.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

Lee, S. L.

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Li, C.

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

Li, H.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Mandel, S. J.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Manohar, S.

Margenthaler, J. A.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Maslov, K.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Mazzaferri, E. L.

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

McIver, B.

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Mehta, K.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Merkulov, A.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Nikiforov, Y. E.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Ntziachristos, V.

A. Dima and V. Ntziachristos, “In-vivo handheld optoacoustic tomography of the human thyroid,” Photoacoustics 4(2), 65–69 (2016).
[Crossref] [PubMed]

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

Oraevsky, A. A.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Pacini, F.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Papini, E.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

Paschke, R.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

Piras, D.

Randolph, G. W.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Reinecke, D. R.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

Salehi, H. S.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Sanders, M.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Sawka, A. M.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Schlumberger, M.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Schuff, K. G.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Schwarz, M.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

Sherman, S. I.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Sosa, J. A.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Steed, D.

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

Steenbergen, W.

Steward, D. L.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Su, R.

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

Theune, U.

S. Guth, U. Theune, J. Aberle, A. Galach, and C. M. Bamberger, “Very high prevalence of thyroid nodules detected by high frequency (13MHz) ultrasound examination,” N. Engl. J. Med. 351, 699–706 (2009).

Tuttle, R. M.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Valcavi, R.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

van de Ven, S. M. W. Y.

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

van den Engh, F. M.

van Hespen, J. C. G.

van Leeuwen, T. G.

Vavadi, H.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Vionnet, L.

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

Vitti, P.

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

Wang, L. V.

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt. 16(2), 026004 (2011).
[Crossref] [PubMed]

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Wartofsky, L.

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Xia, W.

Xu, Y.

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Zackrisson, S.

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

Zhu, Q.

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

Cancer Res. (1)

S. Zackrisson, S. M. W. Y. van de Ven, and S. S. Gambhir, “Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging,” Cancer Res. 74(4), 979–1004 (2014).
[Crossref] [PubMed]

Endocr. Pract. (1)

H. Gharib, E. Papini, J. R. Garber, D. S. Duick, R. M. Harrell, L. Hegedüs, R. Paschke, R. Valcavi, P. Vitti, and AACE/ACE/AME Task Force on Thyroid Nodules, “American Association Of Clinical Endocrinologists, American College Of Endocrinology, And Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis And Management Of Thyroid Nodules–2016 Update,” Endocr. Pract. 22(5), 622–639 (2016).
[PubMed]

IEEE Trans. Med. Imaging (1)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

J. Biomed. Opt. (4)

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

C. P. Favazza, L. A. Cornelius, and L. V. Wang, “In vivo functional photoacoustic microscopy of cutaneous microvasculature in human skin,” J. Biomed. Opt. 16(2), 026004 (2011).
[Crossref] [PubMed]

H. S. Salehi, H. Li, A. Merkulov, P. D. Kumavor, H. Vavadi, M. Sanders, A. Kueck, M. A. Brewer, and Q. Zhu, “Coregistered photoacoustic and ultrasound imaging and classification of ovarian cancer: ex vivo and in vivo studies,” J. Biomed. Opt. 21(4), 046006 (2016).
[Crossref] [PubMed]

M. P. Fronheiser, S. A. Ermilov, H. P. Brecht, A. Conjusteau, R. Su, K. Mehta, and A. A. Oraevsky, “Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature,” J. Biomed. Opt. 15(2), 021305 (2010).
[Crossref] [PubMed]

Med. Phys. (1)

Y. Xu, L. V. Wang, G. Ambartsoumian, and P. Kuchment, “Reconstructions in limited-view thermoacoustic tomography,” Med. Phys. 31(4), 724–733 (2004).
[Crossref] [PubMed]

Medical Imaging, IEEE Transactions on (1)

L. Vionnet, J. Gateau, M. Schwarz, A. Buehler, V. Ermolayev, and V. Ntziachristos, “24MHz Scanner for Optoacoustic Imaging of Skin and Burn,” Medical Imaging, IEEE Transactions on PP, 1 (2013).

Medical Physics (1)

R. A. Kruger, C. M. Kuzmiak, R. B. Lam, D. R. Reinecke, S. P. Del Rio, and D. Steed, “Dedicated 3D photoacoustic breast imaging,” Medical Physics 40, 11 (2013).

N. Engl. J. Med. (2)

S. Guth, U. Theune, J. Aberle, A. Galach, and C. M. Bamberger, “Very high prevalence of thyroid nodules detected by high frequency (13MHz) ultrasound examination,” N. Engl. J. Med. 351, 699–706 (2009).

L. Hegedüs, “Clinical practice. The thyroid nodule,” N. Engl. J. Med. 351(17), 1764–1771 (2004).
[Crossref] [PubMed]

Opt. Express (1)

Photoacoustics (1)

A. Dima and V. Ntziachristos, “In-vivo handheld optoacoustic tomography of the human thyroid,” Photoacoustics 4(2), 65–69 (2016).
[Crossref] [PubMed]

Phys. Med. Biol. (1)

C. Li and L. V. Wang, “Photoacoustic tomography and sensing in biomedicine,” Phys. Med. Biol. 54(19), R59–R97 (2009).
[Crossref] [PubMed]

Sci. Rep. (2)

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

A. Garcia-Uribe, T. N. Erpelding, A. Krumholz, H. Ke, K. Maslov, C. Appleton, J. A. Margenthaler, and L. V. Wang, “Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer,” Sci. Rep. 5(1), 15748 (2015).
[Crossref] [PubMed]

Science (1)

L. V. Wang and S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Thyroid (2)

B. R. Haugen, E. K. Alexander, K. C. Bible, G. M. Doherty, S. J. Mandel, Y. E. Nikiforov, F. Pacini, G. W. Randolph, A. M. Sawka, M. Schlumberger, K. G. Schuff, S. I. Sherman, J. A. Sosa, D. L. Steward, R. M. Tuttle, and L. Wartofsky, “2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer,” Thyroid 26(1), 1–133 (2016).
[Crossref] [PubMed]

D. S. Cooper, G. M. Doherty, B. R. Haugen, R. T. Kloos, S. L. Lee, S. J. Mandel, E. L. Mazzaferri, B. McIver, S. I. Sherman, R. M. Tuttle, and American Thyroid Association Guidelines Taskforce, “Management guidelines for patients with thyroid nodules and differentiated thyroid cancer,” Thyroid 16(2), 109–142 (2006).
[Crossref] [PubMed]

Other (2)

J. Zalev, B. Clingman, D. Herzog, T. Miller, M. Ulissey, A. T. Stavros, A. Oraevsky, P. Lavin, K. Kist, N. C. Dornbluth, and P. Otto, “Opto-acoustic image fusion technology for diagnostic breast imaging in a feasibility study,” in 2015), 941909.

ANSI, “American National Standard for Safe Use of Lasers,” in Z136.1–2000, A. N. S. Institute, ed. (ANSI Standard, NY, 2007).

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Figures (8)

Fig. 1
Fig. 1 PA/US imaging system. (a) Schematic. (b) Photograph of the prototype system.
Fig. 2
Fig. 2 Dual-modality handheld probe. (a) Schematic. (b) Photograph.
Fig. 3
Fig. 3 Dual-modality imaging results of a carbon rod hanged in intralipid solution with different orientation angles (a-c), and different depths (d-f). US results are in gray, and PAI results are in color.
Fig. 4
Fig. 4 Imaging results of human forearm cutaneous vein with longitude section and transverse sections. (a) CDFI result with longitude section; (b) gray scale US B-scan with longitude section; (c) PA/US imaging with longitude section; (d) CDFI result with transverse section; (e) gray scale US B-scan with transverse section; (f) PA/US imaging with transverse section;
Fig. 5
Fig. 5 Imaging results for a healthy right thyroid. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. GP (gel pad), SK (skin), MU (muscle), CA (carotid), TH (thyroid), TR (trachea), VE (vertebrae).
Fig. 6
Fig. 6 Imaging results for a left lobe papillary thyroid cancer (PTC, Follicular variation) with the largest diameter of 9 mm. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. Solid white arrow indicates left lobe PTC, and dashed white arrows indicate suspected feeding vessels.
Fig. 7
Fig. 7 Imaging results for a right lobe PTC with the largest diameter of 13 mm. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. White arrow indicates right lobe PTC.
Fig. 8
Fig. 8 Imaging results for a left lobe papillary thyroid cancer (PTC, Follicular variation) with the largest diameter of 3 mm. (a) CDFI result; (b) gray scale US B-scan; and (c) PA/US imaging result. White arrow indicates the left lobe PTC.

Tables (1)

Tables Icon

Table 1 The clinical information, comparison between PAI and US, and histology results

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