Abstract

We developed an algorithm to remove decorrelation noise due to bulk motion in optical coherence tomography angiography (OCTA) of the posterior eye. In this algorithm, OCTA B-frames were divided into segments within which the bulk motion velocity could be assumed to be constant. This velocity was recovered using linear regression of decorrelation versus the logarithm of reflectance in axial lines (A-lines) identified as bulk tissue by percentile analysis. The fitting parameters were used to calculate a reflectance-adjusted upper bound threshold for bulk motion decorrelation. Below this threshold, voxels are identified as non-flow tissue, their flow values are set to zeros. Above this threshold, the voxels are identified as flow voxels and bulk motion velocity is subtracted from each using a nonlinear decorrelation-velocity relationship previously established in laboratory flow phantoms. Compared to the simpler median-subtraction method, the regression-based bulk motion subtraction improved angiogram signal-to-noise ratio, contrast, vessel density repeatability, and bulk motion noise cleanup in the foveal avascular zone, while preserving the connectivity of the vascular networks in the angiogram.

© 2017 Optical Society of America

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2017 (1)

2016 (10)

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

U. Baran and R. K. Wang, “Review of optical coherence tomography based angiography in neuroscience,” Neurophotonics 3(1), 010902 (2016).
[Crossref] [PubMed]

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

J. P. Su, R. Chandwani, S. S. Gao, A. D. Pechauer, M. Zhang, J. Wang, Y. Jia, D. Huang, and G. Liu, “Calibration of optical coherence tomography angiography with a microfluidic chip,” J. Biomed. Opt. 21(8), 086015 (2016).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

G. Liu, Y. Jia, A. D. Pechauer, R. Chandwani, and D. Huang, “Split-spectrum phase-gradient optical coherence tomography angiography,” Biomed. Opt. Express 7(8), 2943–2954 (2016).
[Crossref] [PubMed]

Z. Chen, M. Liu, M. Minneman, L. Ginner, E. Hoover, H. Sattmann, M. Bonesi, W. Drexler, and R. A. Leitgeb, “Phase-stable swept source OCT angiography in human skin using an akinetic source,” Biomed. Opt. Express 7(8), 3032–3048 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

2015 (11)

S. S. Gao, G. Liu, D. Huang, and Y. Jia, “Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system,” Opt. Lett. 40(10), 2305–2308 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

2014 (5)

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

W. J. Choi and R. K. Wang, “Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography,” Quantum Elec (Woodbury) 44(8), 740–745 (2014).
[Crossref] [PubMed]

M. F. Kraus, J. J. Liu, J. Schottenhamml, C. L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

X. Liu, M. Kirby, and F. Zhao, “Motion analysis and removal in intensity variation based OCT angiography,” Biomed. Opt. Express 5(11), 3833–3847 (2014).
[Crossref] [PubMed]

2013 (2)

2012 (3)

2011 (3)

2010 (1)

L. An, H. M. Subhush, D. J. Wilson, and R. K. Wang, “High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography,” J. Biomed. Opt. 15(2), 026011 (2010).
[Crossref] [PubMed]

2008 (1)

2007 (1)

2006 (1)

2004 (1)

Adhi, M.

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

An, L.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

L. An, H. M. Subhush, D. J. Wilson, and R. K. Wang, “High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography,” J. Biomed. Opt. 15(2), 026011 (2010).
[Crossref] [PubMed]

Ang, M.

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

Arathorn, D. W.

Armour, R. L.

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Bailey, S. T.

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Bansal, M.

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

Baran, U.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

U. Baran and R. K. Wang, “Review of optical coherence tomography based angiography in neuroscience,” Neurophotonics 3(1), 010902 (2016).
[Crossref] [PubMed]

Baumann, B.

Beaton, S.

Boas, D. A.

Bock, R.

Bonesi, M.

Bonini Filho, M. A.

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

Braaf, B.

Branchini, L.

Budai, A.

Cable, A.

Camino, A.

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

Chandwani, R.

G. Liu, Y. Jia, A. D. Pechauer, R. Chandwani, and D. Huang, “Split-spectrum phase-gradient optical coherence tomography angiography,” Biomed. Opt. Express 7(8), 2943–2954 (2016).
[Crossref] [PubMed]

J. P. Su, R. Chandwani, S. S. Gao, A. D. Pechauer, M. Zhang, J. Wang, Y. Jia, D. Huang, and G. Liu, “Calibration of optical coherence tomography angiography with a microfluidic chip,” J. Biomed. Opt. 21(8), 086015 (2016).
[Crossref] [PubMed]

Chen, C. L.

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

M. F. Kraus, J. J. Liu, J. Schottenhamml, C. L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

Chen, C.-L.

Chen, Z.

Chiu, S. J.

Choi, W.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

Choi, W. J.

W. J. Choi and R. K. Wang, “Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography,” Quantum Elec (Woodbury) 44(8), 740–745 (2014).
[Crossref] [PubMed]

Cole, E. D.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

Dansingani, K. K.

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

Davis, E.

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

de Boer, J. F.

de Carlo, T. E.

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

Dongye, C.

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

Drexler, W.

Duker, J. S.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

M. F. Kraus, J. J. Liu, J. Schottenhamml, C. L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

Durbin, M. K.

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Edmunds, B.

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Egan, C. A.

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

Enfield, J.

Estrada, R.

Farsiu, S.

Ferguson, R. D.

Flaxel, C. J.

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Franck, J.

Freund, K. B.

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

Fujimoto, J. G.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

M. F. Kraus, J. J. Liu, J. Schottenhamml, C. L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

Y. Jia, O. Tan, J. Tokayer, B. Potsaid, Y. Wang, J. J. Liu, M. F. Kraus, H. Subhash, J. G. Fujimoto, J. Hornegger, and D. Huang, “Split-spectrum amplitude-decorrelation angiography with optical coherence tomography,” Opt. Express 20(4), 4710–4725 (2012).
[Crossref] [PubMed]

Gao, S. S.

J. P. Su, R. Chandwani, S. S. Gao, A. D. Pechauer, M. Zhang, J. Wang, Y. Jia, D. Huang, and G. Liu, “Calibration of optical coherence tomography angiography with a microfluidic chip,” J. Biomed. Opt. 21(8), 086015 (2016).
[Crossref] [PubMed]

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

S. S. Gao, G. Liu, D. Huang, and Y. Jia, “Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system,” Opt. Lett. 40(10), 2305–2308 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

Gattey, D. M.

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Ginner, L.

Gregori, G.

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Gruber, A.

Hammer, D. X.

Hanson, S. R.

Hendargo, H. C.

Hong, Y.

Hoover, E.

Hornegger, J.

Huang, D.

J. P. Su, R. Chandwani, S. S. Gao, A. D. Pechauer, M. Zhang, J. Wang, Y. Jia, D. Huang, and G. Liu, “Calibration of optical coherence tomography angiography with a microfluidic chip,” J. Biomed. Opt. 21(8), 086015 (2016).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

G. Liu, Y. Jia, A. D. Pechauer, R. Chandwani, and D. Huang, “Split-spectrum phase-gradient optical coherence tomography angiography,” Biomed. Opt. Express 7(8), 2943–2954 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

S. S. Gao, G. Liu, D. Huang, and Y. Jia, “Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system,” Opt. Lett. 40(10), 2305–2308 (2015).
[Crossref] [PubMed]

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Y. Jia, O. Tan, J. Tokayer, B. Potsaid, Y. Wang, J. J. Liu, M. F. Kraus, H. Subhash, J. G. Fujimoto, J. Hornegger, and D. Huang, “Split-spectrum amplitude-decorrelation angiography with optical coherence tomography,” Opt. Express 20(4), 4710–4725 (2012).
[Crossref] [PubMed]

Huang, Y.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Hurst, S.

Husvogt, L.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

Hwang, T. S.

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

Iafe, N. A.

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

Ishibazawa, A.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Ishikawa, H.

Izatt, J. A.

Jacques, S. L.

Jayaraman, V.

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

Jia, Y.

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

J. P. Su, R. Chandwani, S. S. Gao, A. D. Pechauer, M. Zhang, J. Wang, Y. Jia, D. Huang, and G. Liu, “Calibration of optical coherence tomography angiography with a microfluidic chip,” J. Biomed. Opt. 21(8), 086015 (2016).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

G. Liu, Y. Jia, A. D. Pechauer, R. Chandwani, and D. Huang, “Split-spectrum phase-gradient optical coherence tomography angiography,” Biomed. Opt. Express 7(8), 2943–2954 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

S. S. Gao, G. Liu, D. Huang, and Y. Jia, “Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system,” Opt. Lett. 40(10), 2305–2308 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Y. Jia, O. Tan, J. Tokayer, B. Potsaid, Y. Wang, J. J. Liu, M. F. Kraus, H. Subhash, J. G. Fujimoto, J. Hornegger, and D. Huang, “Split-spectrum amplitude-decorrelation angiography with optical coherence tomography,” Opt. Express 20(4), 4710–4725 (2012).
[Crossref] [PubMed]

Jiang, J.

Jonathan, E.

Keane, P. A.

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

Khurana, M.

Kirby, M.

Klein, M. L.

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Ko, T.

Kraus, M. F.

M. F. Kraus, J. J. Liu, J. Schottenhamml, C. L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

Y. Jia, O. Tan, J. Tokayer, B. Potsaid, Y. Wang, J. J. Liu, M. F. Kraus, H. Subhash, J. G. Fujimoto, J. Hornegger, and D. Huang, “Split-spectrum amplitude-decorrelation angiography with optical coherence tomography,” Opt. Express 20(4), 4710–4725 (2012).
[Crossref] [PubMed]

Kubach, S.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Kuehlewein, L.

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

Laron, M.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Lauer, A. K.

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

Leahy, M.

Lee, B.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

Lee, J.

Legarreta, A. D.

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Legarreta, J. E.

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Leitgeb, R. A.

Lenis, T. L.

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

Leung, M. K. K.

Li, D.

Liu, G.

Liu, J. J.

Liu, L.

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

Liu, M.

Liu, X.

Lombardi, L.

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

Lombardi, L. H.

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Lu, C. D.

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Lujan, B.

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

Ma, Z.

Maier, A.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

Makita, S.

Mariampillai, A.

Mayer, M. A.

Minneman, M.

Miura, M.

Moriyama, E. H.

Morrison, J. C.

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Moult, E. M.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

Munce, N. R.

Nagaoka, T.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Novais, E. A.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

Omae, T.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Parikh, M.

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Paunescu, L. A.

Pechauer, A. D.

J. P. Su, R. Chandwani, S. S. Gao, A. D. Pechauer, M. Zhang, J. Wang, Y. Jia, D. Huang, and G. Liu, “Calibration of optical coherence tomography angiography with a microfluidic chip,” J. Biomed. Opt. 21(8), 086015 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

G. Liu, Y. Jia, A. D. Pechauer, R. Chandwani, and D. Huang, “Split-spectrum phase-gradient optical coherence tomography angiography,” Biomed. Opt. Express 7(8), 2943–2954 (2016).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

Ploner, S. B.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

Potsaid, B.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Y. Jia, O. Tan, J. Tokayer, B. Potsaid, Y. Wang, J. J. Liu, M. F. Kraus, H. Subhash, J. G. Fujimoto, J. Hornegger, and D. Huang, “Split-spectrum amplitude-decorrelation angiography with optical coherence tomography,” Opt. Express 20(4), 4710–4725 (2012).
[Crossref] [PubMed]

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

Qi, X.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Qin, W.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Radhakrishnan, H.

Roisman, L.

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Roorda, A.

Rosenfeld, P. J.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Sadda, S. R.

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

Sarraf, D.

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

Sattmann, H.

Schottenhamml, J.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

M. F. Kraus, J. J. Liu, J. Schottenhamml, C. L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

Schuman, J.

Schuman, J. S.

Sharma, U.

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Sheehy, C. K.

Sim, D. A.

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

Sng, C. C. A.

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

Sogawa, K.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Song, S.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Srinivasan, V.

Standish, B. A.

Stetson, P. F.

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Su, J. P.

J. P. Su, R. Chandwani, S. S. Gao, A. D. Pechauer, M. Zhang, J. Wang, Y. Jia, D. Huang, and G. Liu, “Calibration of optical coherence tomography angiography with a microfluidic chip,” J. Biomed. Opt. 21(8), 086015 (2016).
[Crossref] [PubMed]

Subhash, H.

Subhush, H. M.

L. An, H. M. Subhush, D. J. Wilson, and R. K. Wang, “High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography,” J. Biomed. Opt. 15(2), 026011 (2010).
[Crossref] [PubMed]

Takahashi, A.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Takusagawa, H. L.

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
[Crossref] [PubMed]

Tan, O.

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

Y. Jia, O. Tan, J. Tokayer, B. Potsaid, Y. Wang, J. J. Liu, M. F. Kraus, H. Subhash, J. G. Fujimoto, J. Hornegger, and D. Huang, “Split-spectrum amplitude-decorrelation angiography with optical coherence tomography,” Opt. Express 20(4), 4710–4725 (2012).
[Crossref] [PubMed]

Tani, T.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Tiruveedhula, P.

Tokayer, J.

Tomasi, C.

Tufail, A.

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

Vermeer, K. A.

Vienola, K. V.

Vitkin, I. A.

Waheed, N. K.

S. B. Ploner, E. M. Moult, W. Choi, N. K. Waheed, B. Lee, E. A. Novais, E. D. Cole, B. Potsaid, L. Husvogt, J. Schottenhamml, A. Maier, P. J. Rosenfeld, J. S. Duker, J. Hornegger, and J. G. Fujimoto, “Toward quantitative optical coherence tomography angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis,” Retina 36(Suppl 1), 118–126 (2016).
[Crossref] [PubMed]

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
[Crossref] [PubMed]

L. Kuehlewein, K. K. Dansingani, T. E. de Carlo, M. A. Bonini Filho, N. A. Iafe, T. L. Lenis, K. B. Freund, N. K. Waheed, J. S. Duker, S. R. Sadda, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 3 Neovascularization Secondary to Age-Related Macular Degeneration,” Retina 35(11), 2229–2235 (2015).
[Crossref] [PubMed]

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

Wang, J.

Wang, R. K.

C.-L. Chen and R. K. Wang, “Optical coherence tomography based angiography [Invited],” Biomed. Opt. Express 8(2), 1056–1082 (2017).
[Crossref] [PubMed]

U. Baran and R. K. Wang, “Review of optical coherence tomography based angiography in neuroscience,” Neurophotonics 3(1), 010902 (2016).
[Crossref] [PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

W. J. Choi and R. K. Wang, “Volumetric cutaneous microangiography of human skin in vivo by VCSEL swept-source optical coherence tomography,” Quantum Elec (Woodbury) 44(8), 740–745 (2014).
[Crossref] [PubMed]

L. An, H. M. Subhush, D. J. Wilson, and R. K. Wang, “High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography,” J. Biomed. Opt. 15(2), 026011 (2010).
[Crossref] [PubMed]

R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express 15(7), 4083–4097 (2007).
[Crossref] [PubMed]

Wang, X.

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Wang, Y.

Wei, E.

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Wei, W.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Wilkins, M. R.

M. Ang, D. A. Sim, P. A. Keane, C. C. A. Sng, C. A. Egan, A. Tufail, and M. R. Wilkins, “Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging,” Ophthalmology 122(9), 1740–1747 (2015).
[Crossref] [PubMed]

Wilson, B. C.

Wilson, D. J.

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, C. Dongye, A. D. Pechauer, T. S. Hwang, S. T. Bailey, B. Lujan, D. J. Wilson, D. Huang, and Y. Jia, “Automated registration and enhanced processing of clinical optical coherence tomography angiography,” Quant. Imaging Med. Surg. 6(4), 391–401 (2016).
[Crossref] [PubMed]

T. S. Hwang, S. S. Gao, L. Liu, A. K. Lauer, S. T. Bailey, C. J. Flaxel, D. J. Wilson, D. Huang, and Y. Jia, “Automated quantification of capillary nonperfusion using optical coherence tomography angiography in diabetic retinopathy,” JAMA Ophthalmol. 134(4), 367–373 (2016).
[Crossref] [PubMed]

A. Camino, M. Zhang, S. S. Gao, T. S. Hwang, U. Sharma, D. J. Wilson, D. Huang, and Y. Jia, “Evaluation of artifact reduction in optical coherence tomography angiography with real-time tracking and motion correction technology,” Biomed. Opt. Express 7(10), 3905–3915 (2016).
[Crossref] [PubMed]

T. S. Hwang, Y. Jia, S. S. Gao, S. T. Bailey, A. K. Lauer, C. J. Flaxel, D. J. Wilson, and D. Huang, “Optical Coherence Tomography Angiography Features of Diabetic Retinopathy,” Retina 35(11), 2371–2376 (2015).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

Y. Jia, S. T. Bailey, D. J. Wilson, O. Tan, M. L. Klein, C. J. Flaxel, B. Potsaid, J. J. Liu, C. D. Lu, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration,” Ophthalmology 121(7), 1435–1444 (2014).
[Crossref] [PubMed]

L. An, H. M. Subhush, D. J. Wilson, and R. K. Wang, “High-resolution wide-field imaging of retinal and choroidal blood perfusion with optical microangiography,” J. Biomed. Opt. 15(2), 026011 (2010).
[Crossref] [PubMed]

Wollstein, G.

Xu, J.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Yamanari, M.

Yang, Q.

Yang, V. X. D.

Yasuno, Y.

Yatagai, T.

Yokota, H.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Yoshida, A.

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

Zang, P.

Zhang, M.

Zhang, Q.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Q. Zhang, R. K. Wang, C. L. Chen, A. D. Legarreta, M. K. Durbin, L. An, U. Sharma, P. F. Stetson, J. E. Legarreta, L. Roisman, G. Gregori, and P. J. Rosenfeld, “Swept Source Optical Coherence Tomography Angiography of Neovascular Macular Telangiectasia Type 2,” Retina 35(11), 2285–2299 (2015).
[Crossref] [PubMed]

Zhang, T.

Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
[Crossref] [PubMed]

Zhang, X.

Y. Jia, E. Wei, X. Wang, X. Zhang, J. C. Morrison, M. Parikh, L. H. Lombardi, D. M. Gattey, R. L. Armour, B. Edmunds, M. F. Kraus, J. G. Fujimoto, and D. Huang, “Optical coherence tomography angiography of optic disc perfusion in glaucoma,” Ophthalmology 121(7), 1322–1332 (2014).
[Crossref] [PubMed]

Zhao, F.

Am. J. Ophthalmol. (2)

A. Ishibazawa, T. Nagaoka, A. Takahashi, T. Omae, T. Tani, K. Sogawa, H. Yokota, and A. Yoshida, “Optical Coherence Tomography Angiography in Diabetic Retinopathy: A Prospective Pilot Study,” Am. J. Ophthalmol. 160, 35–44 (2015).

L. Kuehlewein, M. Bansal, T. L. Lenis, N. A. Iafe, S. R. Sadda, M. A. Bonini Filho, T. E. De Carlo, N. K. Waheed, J. S. Duker, and D. Sarraf, “Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration,” Am. J. Ophthalmol. 160, 739–748 (2015).

Biomed. Opt. Express (13)

M. F. Kraus, B. Potsaid, M. A. Mayer, R. Bock, B. Baumann, J. J. Liu, J. Hornegger, and J. G. Fujimoto, “Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns,” Biomed. Opt. Express 3(6), 1182–1199 (2012).
[Crossref] [PubMed]

K. V. Vienola, B. Braaf, C. K. Sheehy, Q. Yang, P. Tiruveedhula, D. W. Arathorn, J. F. de Boer, and A. Roorda, “Real-time eye motion compensation for OCT imaging with tracking SLO,” Biomed. Opt. Express 3(11), 2950–2963 (2012).
[Crossref] [PubMed]

B. Braaf, K. V. Vienola, C. K. Sheehy, Q. Yang, K. A. Vermeer, P. Tiruveedhula, D. W. Arathorn, A. Roorda, and J. F. de Boer, “Real-time eye motion correction in phase-resolved OCT angiography with tracking SLO,” Biomed. Opt. Express 4(1), 51–65 (2013).
[Crossref] [PubMed]

H. C. Hendargo, R. Estrada, S. J. Chiu, C. Tomasi, S. Farsiu, and J. A. Izatt, “Automated non-rigid registration and mosaicing for robust imaging of distinct retinal capillary beds using speckle variance optical coherence tomography,” Biomed. Opt. Express 4(6), 803–821 (2013).
[Crossref] [PubMed]

M. F. Kraus, J. J. Liu, J. Schottenhamml, C. L. Chen, A. Budai, L. Branchini, T. Ko, H. Ishikawa, G. Wollstein, J. Schuman, J. S. Duker, J. G. Fujimoto, and J. Hornegger, “Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization,” Biomed. Opt. Express 5(8), 2591–2613 (2014).
[Crossref] [PubMed]

X. Liu, M. Kirby, and F. Zhao, “Motion analysis and removal in intensity variation based OCT angiography,” Biomed. Opt. Express 5(11), 3833–3847 (2014).
[Crossref] [PubMed]

M. Zhang, J. Wang, A. D. Pechauer, T. S. Hwang, S. S. Gao, L. Liu, L. Liu, S. T. Bailey, D. J. Wilson, D. Huang, and Y. Jia, “Advanced image processing for optical coherence tomographic angiography of macular diseases,” Biomed. Opt. Express 6(12), 4661–4675 (2015).
[Crossref] [PubMed]

P. Zang, G. Liu, M. Zhang, C. Dongye, J. Wang, A. D. Pechauer, T. S. Hwang, D. J. Wilson, D. Huang, D. Li, and Y. Jia, “Automated motion correction using parallel-strip registration for wide-field en face OCT angiogram,” Biomed. Opt. Express 7(7), 2823–2836 (2016).
[Crossref] [PubMed]

G. Liu, Y. Jia, A. D. Pechauer, R. Chandwani, and D. Huang, “Split-spectrum phase-gradient optical coherence tomography angiography,” Biomed. Opt. Express 7(8), 2943–2954 (2016).
[Crossref] [PubMed]

Z. Chen, M. Liu, M. Minneman, L. Ginner, E. Hoover, H. Sattmann, M. Bonesi, W. Drexler, and R. A. Leitgeb, “Phase-stable swept source OCT angiography in human skin using an akinetic source,” Biomed. Opt. Express 7(8), 3032–3048 (2016).
[Crossref] [PubMed]

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Q. Zhang, Y. Huang, T. Zhang, S. Kubach, L. An, M. Laron, U. Sharma, and R. K. Wang, “Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking,” J. Biomed. Opt. 20(6), 066008 (2015).
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JAMA Ophthalmol. (2)

L. Liu, Y. Jia, H. L. Takusagawa, A. D. Pechauer, B. Edmunds, L. Lombardi, E. Davis, J. C. Morrison, and D. Huang, “Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma,” JAMA Ophthalmol. 133(9), 1045–1052 (2015).
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Neurophotonics (1)

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Ophthalmology (4)

W. Choi, E. M. Moult, N. K. Waheed, M. Adhi, B. Lee, C. D. Lu, T. E. de Carlo, V. Jayaraman, P. J. Rosenfeld, J. S. Duker, and J. G. Fujimoto, “Ultrahigh-Speed, Swept-Source Optical Coherence Tomography Angiography in Nonexudative Age-Related Macular Degeneration with Geographic Atrophy,” Ophthalmology 122(12), 2532–2544 (2015).
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Quant. Imaging Med. Surg. (1)

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Quantum Elec (Woodbury) (1)

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Retina (4)

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Other (1)

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Figures (10)

Fig. 1
Fig. 1 Linear regression of decorrelation signal (DBM) due to bulk motion as a function of the natural logarithmic tissue reflectance (R). Panel A shows a 6mm × 8mm (horizontal x vertical) OCT angiography scan (400B-frames × 850pixels) from which frames 134, 208, and 336 were selected as examples for moderate, low, and high bulk motion. Panel B shows the cross-sectional B-scans of frames 134 (subtle bulk motion), 208 (moderate bulk motion) and 336 (high bulk motion near microsaccade). SSADA decorrelation signal in red color is overlaid on top of the reflectance OCT signal. Panel C shows the corresponding linear fit of the binned R vs. DBM for the central segment indicated by a red arrow in B. In panel D it is observed that the RMS deviation of un-binned D of non-flow voxels from the fitting curve found at each segment exhibit a linear dependence on the corresponding segment’s slope, shown for all segments forming a volumetric scan.
Fig. 2
Fig. 2 Removal of bulk motion from voxels within each B-frame segment. (A) Decorrelation due to bulk motion (DBM) is modeled as a function of logarithmic reflectance R based linear regression coefficients mk and nk from the regression analysis of the kth frame segment. Voxels with decorrelation value below threshold DTH set at the 97.5 percentile of bulk motion (assuming normal distribution) are classified as non-flow voxels (D set to zero). The bulk motion-induced decorrelation in blood DBM,blood is calculated using the reflectance of blood R blood obtained from the median reflectance of flow voxels (voxel with D above DTH). Bulk motion velocity vBM is obtained from DBM,blood using Eq. (2). (B) The bulk motion velocity is subtracted from a voxel with uncorrected decorrelation value D0 and corresponding velocity v0 that is high relative to the saturation velocity according to the nonlinear curve relating flow signal D to velocity. Therefore subtracting vBM from v0 to obtained corrected velocity v1and corrected flow signal D1 has little effect. (C) The bulk motion velocity is subtracted from a voxel with uncorrected decorrelation value D0 and corresponding velocity v0 that is lower than the saturation velocity. Here subtracting vBM from v0 to obtained corrected velocity v1and corrected flow signal D1 has a larger effect than the previous example.
Fig. 3
Fig. 3 Flow diagram of the bulk-motion (BM)removal algorithm.
Fig. 4
Fig. 4 Skeletonization of an en face angiogram. Close up of the foveal region is shown for better visualization. (A) Original angiogram. (B) Skeletonized version by applying the algorithm described in [41] separately on vessels of different calibers. This algorithm is executed by the function bwmorph in Matlab’s Image Processing Toolbox. (C) Inaccurate skeletonization obtained by the same algorithm applied directly on the original en face angiogram. Vessels of larger caliber on the upper left corner are almost indistinguishable.
Fig. 5
Fig. 5 Selection of the background A-lines. (A) 6 × 8mm en face inner retinal angiogram on macula.(B) Identification of A-lines containing large vessel flow signal or microsaccadic artifacts. (C) Map of the A-lines contained within the lowest 10 percentile of maximum projection values (green) after removing the large vessel mask in (B) overlaid on top of the en face angiogram (purple). (D) Distribution of the number of A-lines selected for regression analysis in the 2000 segments.
Fig. 6
Fig. 6 Within-frame variation of bulk motion. En face image of an unprocessed macular scan is shown in (A). A black arrow indicates the position of a frame of interest. Appearance of artefactual frames varied along the vertical axis due to changes in local reflectance. Fitting slope of each of the five segments into which the frame is partitioned is shown in (B).
Fig. 7
Fig. 7 Removal of bulk motion signal from a macular OCTA scan. (A) Unprocessed en face retinal angiogram. (B) After removal of decorrelation signal from bulk motion voxels using a reflectance-adjusted threshold. (C) Difference between images A and B. (D) After subtraction of bulk motion velocity from the vascular voxels. (E) Difference between images B and D.
Fig. 8
Fig. 8 Qualitative comparison between median subtraction and regression-based bulk motion subtraction in an optic disc scan (A1-A7) and a macular scan (B1-B7).A1, B1 Unprocessed en face images. A2, B2 Scans after subtracting the median of the frame’s retinal region. A3, B3 are obtained by subtracting A1-A2 and B1-B2 respectively. A4, B4 Scans after regression-based bulk motion subtraction. A5, B5 are obtained by subtracting A1-A4 and B1-B4 respectively. A6 and A7 are close-ups of the 3.8mm × 1.7mm sections enclosed by dashed lines on A2 and A4 respectively.B6 and B7 are close-ups of the 3.4mm × 2.5mm sections enclosed by dashed lines on B2 and B4 respectively.
Fig. 9
Fig. 9 Qualitative comparison between two bulk motion subtraction algorithms applied to a non-microsaccadic B-frame with large contribution of bulk-motion. Projection artifacts are not corrected. A Reflectance image. B Unprocessed flow image. C Flow image after median subtraction. D Flow image after regression-based bulk motion subtraction. E and F are close-ups of the 1.3 mm B-scan sections enclosed by dashed lines in C and D respectively.
Fig. 10
Fig. 10 Investigation of the benefits of bulk motion pre-compensation by optimization of the bulk image shifts of the OCT images previous to OCTA processing by SSADA. A En face original OCTA without pre-compensation. B En face OCTA after regression-based bulk motion subtraction from the data set used in A. C Original en face non-thresholded OCTA after inter-B-scan registration. D Result of applying the regression-based bulk motion subtraction on the data set used for C. The residual artifacts still observed in B are better removed in D. E and F are close-ups of the regions enclosed by dashed lines in B and D respectively. Better capillary-background contrast was observed in E. G is a binary vessel mask obtained by imposing a fixed threshold on C while H is obtained by imposing a local regression-based threshold at each segment of a frame. Region enclosed shows that pre-compensation by inter-B-scan registration does not correct the vessel density dependence on local signal strength. Contrastingly, by a regression-based local thresholding a more homogeneous perfusion is identified for the whole scan in H.

Tables (1)

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Table 1 Performance Evaluation of Two Bulk Motion Subtraction Methods

Equations (5)

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D TH =(m R k +n ) k +1.96(a+bm ) k
v BM = 1 3 v sat ln( 1  D BM,blood D brownian D sat D brownian )
D 1 =( D sat D brownian )exp(  3 v 0 v BM v sat )+ D brownian
SNR=  D ¯ parafoveal D ¯ FAZ σ D FAZ
C RMS =  1 A × (x,y)A (D(x,y) D ¯ ) 2

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