Abstract

Photoacoustic tomography (PAT) is an emerging noninvasive biomedical imaging modality that can be used for visualizing the structure and function of brain in high resolution. Here we report an application of PAT to imaging intracerebral hemorrhage (ICH) in a mouse model. In vivo photoacoustic images were obtained in mice with right basal ganglia hemorrhage induced by microinjection of collagenase. With multi-spectral light excitation, cortical vascular network was clearly revealed at 532 nm, and ICH associated hematoma lesions and perihemmatoma regions were accurately mapped over time at 750 nm and 875 nm, respectively. Our results suggest that PAT provides a unique tool for visualizing hemodynamics involved in brain diseases such as ICH.

© 2017 Optical Society of America

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References

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2016 (2)

C. F. Tsai, N. Anderson, B. Thomas, and C. L. M. Sudlow, “Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis,” PLoS One 11(3), e0151743 (2016).
[Crossref] [PubMed]

N. Huang, H. Guo, W. Qi, Z. Zhang, J. Rong, Z. Yuan, W. Ge, H. Jiang, and L. Xi, “Whole-body multispectral photoacoustic imaging of adult zebrafish,” Biomed. Opt. Express 7(9), 3543–3550 (2016).
[Crossref] [PubMed]

2015 (4)

L. Xi and H. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107(6), 063701 (2015).
[Crossref]

P. K. Upputuri and M. Pramanik, “Performance characterization of low-cost, high-speed, portable pulsed laser diode photoacoustic tomography (PLD-PAT) system,” Biomed. Opt. Express 6(10), 4118–4129 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

2014 (1)

D. Wu, L. Huang, M. S. Jiang, and H. Jiang, “Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review,” Int. J. Mol. Sci. 15(12), 23616–23639 (2014).
[Crossref] [PubMed]

2013 (1)

X. Jiang, M. Liu, and C. You, “Advances in classification of intracerebral hemorrhage,” Int. J. Cerebrovase Dis. 21(3), 207–210 (2013).

2012 (4)

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, “Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple organs,” PLoS One 7(1), e30491 (2012).
[Crossref] [PubMed]

L. Xi, S. R. Grobmyer, L. Wu, R. Chen, G. Zhou, L. G. Gutwein, J. Sun, W. Liao, Q. Zhou, H. Xie, and H. Jiang, “Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging,” Opt. Express 20(8), 8726–8731 (2012).
[Crossref] [PubMed]

C. F. Tsai, B. Thomas, and C. L. M. Sudlow, “Differences in the epidemiology of stroke and its subtypes in Chinese populations versus white populations of European origin-systematic review,” Int. J. Stroke 7, 35 (2012).

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

2011 (2)

V. L. Feigin and R. Krishnamurthi, “Stroke prevention in the developing world,” Stroke 42(12), 3655–3658 (2011).
[Crossref] [PubMed]

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

2010 (2)

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

L. Yan, H. Liu, and J. Li, “Comparison and application of CT hemotoma volume measurement software with Duotian formula,” Hebei Medical J. 16, 003 (2010).

2009 (1)

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

2008 (1)

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

2007 (2)

D. W. Yang, D. Xing, S. H. Yang, and L. Z. Xiang, “Fast full-view photoacoustic imaging by combined scanning with a linear transducer array,” Opt. Express 15(23), 15566–15575 (2007).
[Crossref] [PubMed]

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

2006 (2)

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

C. D. Mathers and D. Loncar, “Projections of global mortality and burden of disease from 2002 to 2030,” PLoS Med. 3(11), e442 (2006).
[Crossref] [PubMed]

2005 (1)

R. N. Auer and G. R. Sutherland, “Primary intracerebral hemorrhage: pathophysiology,” Can. J. Neurol. Sci. 32(5Suppl 2), S3–S12 (2005).
[PubMed]

2004 (1)

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

2003 (2)

M. E. Fewel, B. G. Thompson, and J. T. Hoff, “Spontaneous Intracerebral Hemorrhage: A Review,” Neurosurg. Focus 15(4), 1 (2003).
[Crossref] [PubMed]

D. Xie, “Treatment of Intracerebral Hemorrhage,” Chin. J. Integr. Med. 1, 6–7 (2003).

2002 (1)

S. A. Mayer, “Intracerebral hemorrhage: natural history and rationale of ultra-early hemostatic therapy,” Intensive Care Med. 28( Suppl 2), S235–S240 (2002).
[Crossref] [PubMed]

1999 (2)

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

T. O. McBride, B. W. Pogue, E. D. Gerety, S. B. Poplack, U. L. Österberg, and K. D. Paulsen, “Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue,” Appl. Opt. 38(25), 5480–5490 (1999).
[Crossref] [PubMed]

1998 (1)

G. Xi, R. F. Keep, and J. T. Hoff, “Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats,” J. Neurosurg. 89(6), 991–996 (1998).
[Crossref] [PubMed]

1990 (1)

G. A. Rosenberg, S. Mun-Bryce, M. Wesley, and M. Kornfeld, “Collagenase-induced intracerebral hemorrhage in rats,” Stroke 21(5), 801–807 (1990).
[Crossref] [PubMed]

1880 (1)

A. G. Bell, “On the production and reproduction of sound by light,” Am. J. Sci. 20(118), 305–324 (1880).
[Crossref]

Adams, H. P.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Alger, J. R.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Algra, A.

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

Anastasio, M. A.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

Anderson, N.

C. F. Tsai, N. Anderson, B. Thomas, and C. L. M. Sudlow, “Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis,” PLoS One 11(3), e0151743 (2016).
[Crossref] [PubMed]

Auer, R. N.

R. N. Auer and G. R. Sutherland, “Primary intracerebral hemorrhage: pathophysiology,” Can. J. Neurol. Sci. 32(5Suppl 2), S3–S12 (2005).
[PubMed]

Baird, A. E.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Barker-Collo, S. L.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Barsan, W.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Beard, P.

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

Bell, A. G.

A. G. Bell, “On the production and reproduction of sound by light,” Am. J. Sci. 20(118), 305–324 (1880).
[Crossref]

Bennett, D. A.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Broderick, J. P.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Burton, N. C.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, “Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple organs,” PLoS One 7(1), e30491 (2012).
[Crossref] [PubMed]

Butman, J. A.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Cai, X.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

Carney, P. R.

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

Chalela, J. A.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Chen, H.

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

Chen, R.

Davis, L.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Davis, S.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Demchuk, A. M.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Dizaji, A. S.

A. S. Dizaji and S. Z. Hamid, “A Change-point Analysis Method for Single-trial Study of Simultaneous EEG-fMRI of Auditory/Visual Oddball Task,” (2017).
[Crossref]

Dunn, B.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Dziewiatkowski, J.

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

Ezzeddine, M. A.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Feigin, V. L.

V. L. Feigin and R. Krishnamurthi, “Stroke prevention in the developing world,” Stroke 42(12), 3655–3658 (2011).
[Crossref] [PubMed]

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Feinberg, W.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Feldmann, E.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Fewel, M. E.

M. E. Fewel, B. G. Thompson, and J. T. Hoff, “Spontaneous Intracerebral Hemorrhage: A Review,” Neurosurg. Focus 15(4), 1 (2003).
[Crossref] [PubMed]

Fredieu, A.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Garcia-Uribe, A.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

Ge, W.

Gerety, E. D.

Grobmyer, S. R.

Grotta, J.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Guo, H.

Gutwein, L. G.

Hamid, S. Z.

A. S. Dizaji and S. Z. Hamid, “A Change-point Analysis Method for Single-trial Study of Simultaneous EEG-fMRI of Auditory/Visual Oddball Task,” (2017).
[Crossref]

Haymore, J.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Hill, M. D.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Hoff, J. T.

M. E. Fewel, B. G. Thompson, and J. T. Hoff, “Spontaneous Intracerebral Hemorrhage: A Review,” Neurosurg. Focus 15(4), 1 (2003).
[Crossref] [PubMed]

G. Xi, R. F. Keep, and J. T. Hoff, “Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats,” J. Neurosurg. 89(6), 991–996 (1998).
[Crossref] [PubMed]

Huang, H.

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

Huang, L.

D. Wu, L. Huang, M. S. Jiang, and H. Jiang, “Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review,” Int. J. Mol. Sci. 15(12), 23616–23639 (2014).
[Crossref] [PubMed]

Huang, N.

Jiang, H.

N. Huang, H. Guo, W. Qi, Z. Zhang, J. Rong, Z. Yuan, W. Ge, H. Jiang, and L. Xi, “Whole-body multispectral photoacoustic imaging of adult zebrafish,” Biomed. Opt. Express 7(9), 3543–3550 (2016).
[Crossref] [PubMed]

L. Xi and H. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107(6), 063701 (2015).
[Crossref]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

D. Wu, L. Huang, M. S. Jiang, and H. Jiang, “Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review,” Int. J. Mol. Sci. 15(12), 23616–23639 (2014).
[Crossref] [PubMed]

L. Xi, S. R. Grobmyer, L. Wu, R. Chen, G. Zhou, L. G. Gutwein, J. Sun, W. Liao, Q. Zhou, H. Xie, and H. Jiang, “Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging,” Opt. Express 20(8), 8726–8731 (2012).
[Crossref] [PubMed]

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

Jiang, M. S.

D. Wu, L. Huang, M. S. Jiang, and H. Jiang, “Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review,” Int. J. Mol. Sci. 15(12), 23616–23639 (2014).
[Crossref] [PubMed]

Jiang, X.

X. Jiang, M. Liu, and C. You, “Advances in classification of intracerebral hemorrhage,” Int. J. Cerebrovase Dis. 21(3), 207–210 (2013).

Karwacka, M.

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

Karwacki, Z.

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

Kase, C.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Keep, R. F.

G. Xi, R. F. Keep, and J. T. Hoff, “Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats,” J. Neurosurg. 89(6), 991–996 (1998).
[Crossref] [PubMed]

Kidwell, C. S.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Klijn, C. J.

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

Kornfeld, M.

G. A. Rosenberg, S. Mun-Bryce, M. Wesley, and M. Kornfeld, “Collagenase-induced intracerebral hemorrhage in rats,” Stroke 21(5), 801–807 (1990).
[Crossref] [PubMed]

Kowianski, P.

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

Krieger, D.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Krishnamurthi, R.

V. L. Feigin and R. Krishnamurthi, “Stroke prevention in the developing world,” Stroke 42(12), 3655–3658 (2011).
[Crossref] [PubMed]

Latour, L. L.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Lawes, C. M.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Leary, M. C.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
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Li, J.

L. Yan, H. Liu, and J. Li, “Comparison and application of CT hemotoma volume measurement software with Duotian formula,” Hebei Medical J. 16, 003 (2010).

Liao, W.

Liu, H.

L. Yan, H. Liu, and J. Li, “Comparison and application of CT hemotoma volume measurement software with Duotian formula,” Hebei Medical J. 16, 003 (2010).

Liu, M.

X. Jiang, M. Liu, and C. You, “Advances in classification of intracerebral hemorrhage,” Int. J. Cerebrovase Dis. 21(3), 207–210 (2013).

Liu, Z.

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

Loncar, D.

C. D. Mathers and D. Loncar, “Projections of global mortality and burden of disease from 2002 to 2030,” PLoS Med. 3(11), e442 (2006).
[Crossref] [PubMed]

Luby, M. L.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Luitse, M. J.

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

Lynch, J. K.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Maslov, K.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

Mathers, C. D.

C. D. Mathers and D. Loncar, “Projections of global mortality and burden of disease from 2002 to 2030,” PLoS Med. 3(11), e442 (2006).
[Crossref] [PubMed]

Mayberg, M.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Mayer, S. A.

S. A. Mayer, “Intracerebral hemorrhage: natural history and rationale of ultra-early hemostatic therapy,” Intensive Care Med. 28( Suppl 2), S235–S240 (2002).
[Crossref] [PubMed]

McBride, T. O.

Mitin, S. D.

S. D. Mitin, “Hemorrhage - intracerebral (deep),” Cancer (2012).

Morscher, S.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, “Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple organs,” PLoS One 7(1), e30491 (2012).
[Crossref] [PubMed]

Morys, J.

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

Mun-Bryce, S.

G. A. Rosenberg, S. Mun-Bryce, M. Wesley, and M. Kornfeld, “Collagenase-induced intracerebral hemorrhage in rats,” Stroke 21(5), 801–807 (1990).
[Crossref] [PubMed]

Nie, L.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

Ntziachristos, V.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, “Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple organs,” PLoS One 7(1), e30491 (2012).
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D. Razansky and V. Ntziachristos, “Multi-Spectral Optoacoustic Tomography: Next Generation Platform for High Resolution Imaging of Diffuse Tissues,” Asia Communications and Photonics Conference and Exhibition IEEE, 1–2 (2009).

Österberg, U. L.

Ovbiagele, B.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Parag, V.

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

Patronas, N.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Paulsen, K. D.

Pogue, B. W.

Poplack, S. B.

Pramanik, M.

Qi, W.

Razansky, D.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, “Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple organs,” PLoS One 7(1), e30491 (2012).
[Crossref] [PubMed]

D. Razansky and V. Ntziachristos, “Multi-Spectral Optoacoustic Tomography: Next Generation Platform for High Resolution Imaging of Diffuse Tissues,” Asia Communications and Photonics Conference and Exhibition IEEE, 1–2 (2009).

Rinkel, G. J.

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

Rong, J.

Roper, S. N.

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

Rosenberg, G. A.

G. A. Rosenberg, S. Mun-Bryce, M. Wesley, and M. Kornfeld, “Collagenase-induced intracerebral hemorrhage in rats,” Stroke 21(5), 801–807 (1990).
[Crossref] [PubMed]

Saver, J. L.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Starkman, S.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Sudlow, C. L. M.

C. F. Tsai, N. Anderson, B. Thomas, and C. L. M. Sudlow, “Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis,” PLoS One 11(3), e0151743 (2016).
[Crossref] [PubMed]

C. F. Tsai, B. Thomas, and C. L. M. Sudlow, “Differences in the epidemiology of stroke and its subtypes in Chinese populations versus white populations of European origin-systematic review,” Int. J. Stroke 7, 35 (2012).

Sun, J.

Sutherland, G. R.

R. N. Auer and G. R. Sutherland, “Primary intracerebral hemorrhage: pathophysiology,” Can. J. Neurol. Sci. 32(5Suppl 2), S3–S12 (2005).
[PubMed]

Suzuki, S.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Tang, J.

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

Taruttis, A.

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, “Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple organs,” PLoS One 7(1), e30491 (2012).
[Crossref] [PubMed]

Thomas, B.

C. F. Tsai, N. Anderson, B. Thomas, and C. L. M. Sudlow, “Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis,” PLoS One 11(3), e0151743 (2016).
[Crossref] [PubMed]

C. F. Tsai, B. Thomas, and C. L. M. Sudlow, “Differences in the epidemiology of stroke and its subtypes in Chinese populations versus white populations of European origin-systematic review,” Int. J. Stroke 7, 35 (2012).

Thompson, B. G.

M. E. Fewel, B. G. Thompson, and J. T. Hoff, “Spontaneous Intracerebral Hemorrhage: A Review,” Neurosurg. Focus 15(4), 1 (2003).
[Crossref] [PubMed]

Tilley, B.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Todd, J. W.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Tremwel, M.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Tsai, C. F.

C. F. Tsai, N. Anderson, B. Thomas, and C. L. M. Sudlow, “Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis,” PLoS One 11(3), e0151743 (2016).
[Crossref] [PubMed]

C. F. Tsai, B. Thomas, and C. L. M. Sudlow, “Differences in the epidemiology of stroke and its subtypes in Chinese populations versus white populations of European origin-systematic review,” Int. J. Stroke 7, 35 (2012).

Upputuri, P. K.

van Asch, C. J.

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

van der Tweel, I.

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

Villablanca, J. P.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Wang, L. V.

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

Warach, S.

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Wesley, M.

G. A. Rosenberg, S. Mun-Bryce, M. Wesley, and M. Kornfeld, “Collagenase-induced intracerebral hemorrhage in rats,” Stroke 21(5), 801–807 (1990).
[Crossref] [PubMed]

Witkowska, M.

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

Wu, D.

D. Wu, L. Huang, M. S. Jiang, and H. Jiang, “Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review,” Int. J. Mol. Sci. 15(12), 23616–23639 (2014).
[Crossref] [PubMed]

Wu, L.

Xi, G.

G. Xi, R. F. Keep, and J. T. Hoff, “Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats,” J. Neurosurg. 89(6), 991–996 (1998).
[Crossref] [PubMed]

Xi, L.

N. Huang, H. Guo, W. Qi, Z. Zhang, J. Rong, Z. Yuan, W. Ge, H. Jiang, and L. Xi, “Whole-body multispectral photoacoustic imaging of adult zebrafish,” Biomed. Opt. Express 7(9), 3543–3550 (2016).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

L. Xi and H. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107(6), 063701 (2015).
[Crossref]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

L. Xi, S. R. Grobmyer, L. Wu, R. Chen, G. Zhou, L. G. Gutwein, J. Sun, W. Liao, Q. Zhou, H. Xie, and H. Jiang, “Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging,” Opt. Express 20(8), 8726–8731 (2012).
[Crossref] [PubMed]

Xiang, L. Z.

Xie, D.

D. Xie, “Treatment of Intracerebral Hemorrhage,” Chin. J. Integr. Med. 1, 6–7 (2003).

Xie, H.

Xing, D.

Yan, L.

L. Yan, H. Liu, and J. Li, “Comparison and application of CT hemotoma volume measurement software with Duotian formula,” Hebei Medical J. 16, 003 (2010).

Yang, D. W.

Yang, S. H.

You, C.

X. Jiang, M. Liu, and C. You, “Advances in classification of intracerebral hemorrhage,” Int. J. Cerebrovase Dis. 21(3), 207–210 (2013).

Yuan, Z.

N. Huang, H. Guo, W. Qi, Z. Zhang, J. Rong, Z. Yuan, W. Ge, H. Jiang, and L. Xi, “Whole-body multispectral photoacoustic imaging of adult zebrafish,” Biomed. Opt. Express 7(9), 3543–3550 (2016).
[Crossref] [PubMed]

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

Zabramski, J. M.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Zhang, H. F.

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

Zhang, Q.

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

Zhang, T.

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

Zhang, Z.

Zhou, G.

Zhou, J.

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

Zhou, Q.

Zuccarello, M.

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Am. J. Sci. (1)

A. G. Bell, “On the production and reproduction of sound by light,” Am. J. Sci. 20(118), 305–324 (1880).
[Crossref]

Appl. Opt. (1)

Appl. Phys. Lett. (1)

L. Xi and H. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107(6), 063701 (2015).
[Crossref]

Biomed. Opt. Express (2)

Can. J. Neurol. Sci. (1)

R. N. Auer and G. R. Sutherland, “Primary intracerebral hemorrhage: pathophysiology,” Can. J. Neurol. Sci. 32(5Suppl 2), S3–S12 (2005).
[PubMed]

Chin. J. Integr. Med. (1)

D. Xie, “Treatment of Intracerebral Hemorrhage,” Chin. J. Integr. Med. 1, 6–7 (2003).

Folia Morphol. (Warsz) (1)

Z. Karwacki, P. Kowiański, M. Witkowska, M. Karwacka, J. Dziewiatkowski, and J. Moryś, “The pathophysiology of intracerebral haemorrhage,” Folia Morphol. (Warsz) 65(4), 295–300 (2006).
[PubMed]

Hebei Medical J. (1)

L. Yan, H. Liu, and J. Li, “Comparison and application of CT hemotoma volume measurement software with Duotian formula,” Hebei Medical J. 16, 003 (2010).

Int. J. Cerebrovase Dis. (1)

X. Jiang, M. Liu, and C. You, “Advances in classification of intracerebral hemorrhage,” Int. J. Cerebrovase Dis. 21(3), 207–210 (2013).

Int. J. Mol. Sci. (1)

D. Wu, L. Huang, M. S. Jiang, and H. Jiang, “Contrast Agents for Photoacoustic and Thermoacoustic Imaging: A Review,” Int. J. Mol. Sci. 15(12), 23616–23639 (2014).
[Crossref] [PubMed]

Int. J. Stroke (1)

C. F. Tsai, B. Thomas, and C. L. M. Sudlow, “Differences in the epidemiology of stroke and its subtypes in Chinese populations versus white populations of European origin-systematic review,” Int. J. Stroke 7, 35 (2012).

Intensive Care Med. (1)

S. A. Mayer, “Intracerebral hemorrhage: natural history and rationale of ultra-early hemostatic therapy,” Intensive Care Med. 28( Suppl 2), S235–S240 (2002).
[Crossref] [PubMed]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

Inverse Probl. (1)

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

J. Biomed. Opt. (1)

L. Nie, X. Cai, K. Maslov, A. Garcia-Uribe, M. A. Anastasio, and L. V. Wang, “Photoacoustic tomography through a whole adult human skull with a photon recycler,” J. Biomed. Opt. 17(11), 110506 (2012).
[Crossref] [PubMed]

J. Cereb. Blood Flow Metab. (2)

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Tang, L. Xi, J. Zhou, H. Huang, T. Zhang, P. R. Carney, and H. Jiang, “Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats,” J. Cereb. Blood Flow Metab. 35(8), 1224–1232 (2015).
[Crossref] [PubMed]

J. Neurosurg. (1)

G. Xi, R. F. Keep, and J. T. Hoff, “Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats,” J. Neurosurg. 89(6), 991–996 (1998).
[Crossref] [PubMed]

JAMA (1)

C. S. Kidwell, J. A. Chalela, J. L. Saver, S. Starkman, M. D. Hill, A. M. Demchuk, J. A. Butman, N. Patronas, J. R. Alger, L. L. Latour, M. L. Luby, A. E. Baird, M. C. Leary, M. Tremwel, B. Ovbiagele, A. Fredieu, S. Suzuki, J. P. Villablanca, S. Davis, B. Dunn, J. W. Todd, M. A. Ezzeddine, J. Haymore, J. K. Lynch, L. Davis, and S. Warach, “Comparison of MRI and CT for detection of acute intracerebral hemorrhage,” JAMA 292(15), 1823–1830 (2004).
[Crossref] [PubMed]

Lancet Neurol. (2)

V. L. Feigin, C. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, “Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review,” Lancet Neurol. 8(4), 355–369 (2009).
[Crossref] [PubMed]

C. J. van Asch, M. J. Luitse, G. J. Rinkel, I. van der Tweel, A. Algra, and C. J. Klijn, “Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis,” Lancet Neurol. 9(2), 167–176 (2010).
[Crossref] [PubMed]

Neurosurg. Focus (1)

M. E. Fewel, B. G. Thompson, and J. T. Hoff, “Spontaneous Intracerebral Hemorrhage: A Review,” Neurosurg. Focus 15(4), 1 (2003).
[Crossref] [PubMed]

Opt. Express (2)

Phys. Med. Biol. (1)

Q. Zhang, Z. Liu, P. R. Carney, Z. Yuan, H. Chen, S. N. Roper, and H. Jiang, “Non-invasive imaging of epileptic seizures in vivo using photoacoustic tomography,” Phys. Med. Biol. 53(7), 1921–1931 (2008).
[Crossref] [PubMed]

PLoS Med. (1)

C. D. Mathers and D. Loncar, “Projections of global mortality and burden of disease from 2002 to 2030,” PLoS Med. 3(11), e442 (2006).
[Crossref] [PubMed]

PLoS One (2)

C. F. Tsai, N. Anderson, B. Thomas, and C. L. M. Sudlow, “Comparing Risk Factor Profiles between Intracerebral Hemorrhage and Ischemic Stroke in Chinese and White Populations: Systematic Review and Meta-Analysis,” PLoS One 11(3), e0151743 (2016).
[Crossref] [PubMed]

A. Taruttis, S. Morscher, N. C. Burton, D. Razansky, and V. Ntziachristos, “Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple organs,” PLoS One 7(1), e30491 (2012).
[Crossref] [PubMed]

Stroke (3)

G. A. Rosenberg, S. Mun-Bryce, M. Wesley, and M. Kornfeld, “Collagenase-induced intracerebral hemorrhage in rats,” Stroke 21(5), 801–807 (1990).
[Crossref] [PubMed]

V. L. Feigin and R. Krishnamurthi, “Stroke prevention in the developing world,” Stroke 42(12), 3655–3658 (2011).
[Crossref] [PubMed]

J. P. Broderick, H. P. Adams, W. Barsan, W. Feinberg, E. Feldmann, J. Grotta, C. Kase, D. Krieger, M. Mayberg, B. Tilley, J. M. Zabramski, and M. Zuccarello, “Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association,” Stroke 30(4), 905–915 (1999).
[Crossref] [PubMed]

Other (11)

P. V. Patel, L. Elijovich, and J. C. Hemphill III, “Intracerebral Hemorrhage,” in Emergency Neurology, K. L. Roos, ed. (Springer US, 2012), pp. 1274–1278.

S. D. Mitin, “Hemorrhage - intracerebral (deep),” Cancer (2012).

D. Qin, “Overview of MicroCT with Higher Spare Resolution than Normal CT,” China Medical Devices Information (2003).

A. S. Dizaji and S. Z. Hamid, “A Change-point Analysis Method for Single-trial Study of Simultaneous EEG-fMRI of Auditory/Visual Oddball Task,” (2017).
[Crossref]

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Figures (6)

Fig. 1
Fig. 1 (a) Schematic showing the location of bregma (yellow dot) and collagenase injection point (red dot). (b) Schematic of our PAT system for in vivo monitoring the collagenase induced intracerebral hemorrhage (ICH).
Fig. 2
Fig. 2 In vivo imaging of an ICH mouse brain at 750nm in transverse plane. (A) PAT image acquired 2 hours post the induction of ICH. The hematoma lesion and some background were clearly identified (green square). (B) Close-up view of the area outlined by the green square in Fig. 2(a). Scale bar = 1 mm.
Fig. 3
Fig. 3 In vivo imaging of hematoma lesion and perihemmatoma regions in an ICH mouse brain at 750nm (horizontal plane). (A) PAT image of a normal mouse brain before ICH induction. (B) PAT image acquired 4 hours after ICH induction. The hematoma lesion was identified (ellipse in green), and the perihemmatoma regions were also delineated (blue dashed arrows). (C) Open-scalp photograph of the mouse brain surface after the PAT imaging. The injection point was indicated by yellow circle. Dashed line in (A) and (B) indicates the center plane of the brain. Scale bar = 1 mm.
Fig. 4
Fig. 4 In vivo imaging of an ICH mouse brain (horizontal plane), 18 hours post the induction of ICH at 532 nm (Fig. 4(b), 750 nm (Fig. 4(a)) and 875 nm (Fig. 4(c)). (d) an overlay of Fig. 4(a) (saffron yellow) over Fig. 4(b) (gray). (e) Open-skull photograph of the mouse brain surface after the imaging experiments. The injection point was indicated by yellow circle. (f) an overlay of Fig. 4(c) (green) over Fig. 4(b) (gray); the cortical vascular network and the hematoma show good colocalization. The hematoma lesion was clearly identified (ellipse in red), and the perihemmatoma regions were ischemia and also revealed (blue dashed arrows). Scale bar = 1 mm for photoacoustic images. (G) Histological photograph of three brain slices in a coronal plane from the front of the head to the back. Scale bar = 1 cm for the photographs of brain slices.
Fig. 5
Fig. 5 In vivo imaging of an ICH mouse brain (horizontal plane) at 750 nm (a-d) and 875 nm (e-h), and sO2 distribution(i-l), before ICH induction (a, e), 2 hours post ICH induction (b, f), 6 hours post ICH induction (c, g), and 10 hours post ICH induction (d, h). The pink triangle indicates serious local ischemia. The hematoma lesion was clearly identified (ellipse in green), and the perihemmatoma regions were ischemia and also clearly identified (blue dashed arrows). Scale bar = 1 mm.
Fig. 6
Fig. 6 Histogram of the percentage variation (SEM) of the hematoma area (see Fig. 5(a)) over time (n = 4), from 2 to 10 hours post ICH induction. Histogram of the percentage variation (SEM) of sO2 in the hematoma lesion (see Fig. 5(b)) over time (n = 4): before ICH induction, and 2 to 10 hours post ICH induction. The error bar indicated the standard deviation.

Equations (3)

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s O 2(x,y,z) = C Hb O 2 (x,y,z) C HbT(x,y,z)
[ C Hb C HbO ] (x,y,z) = ( [ ε Hb ( 750 ) ε Hb O 2 ( 750 ) ε Hb ( 875 ) ε Hb O 2 ( 875 ) ] T [ ε Hb ( 750 ) ε Hb O 2 ( 750 ) ε Hb ( 875 ) ε Hb O 2 ( 875 ) ] ) 1 [ ε Hb ( 750 ) ε Hb O 2 ( 750 ) ε Hb ( 875 ) ε Hb O 2 ( 875 ) ] T [ φ 750 (x,y,z) φ 875 (x,y,z) ] κ
Area(ICH)= π 4 ab

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