Abstract

The thermal effect of high intensity focused ultrasound (HIFU) has been clinically exploited over a decade, while the mechanical HIFU is still largely confined to laboratory investigations. This is in part due to the lack of adequate imaging techniques to better understand the in-vivo pathological and immunological effects caused by the mechanical treatment. In this work, we explore the use of high frequency ultrasound (US) and photoacoustics (PA) as a potential tool to evaluate the effect of mechanical ablation in-vivo, e.g. boiling histotripsy. Two mice bearing a neuroblastoma tumor in the right leg were ablated using an MRI-HIFU system conceived for small animals and monitored using MRI thermometry. High frequency US and PA imaging were performed before and after the HIFU treatment. Afterwards, the tumor was resected for further assessment and evaluation of the ablated region using histopathology. High frequency US imaging revealed the presence of liquefied regions in the treated area together with fragmentized tissue which appeared with different reflecting proprieties compared to the surrounding tissue. Photoacoustic imaging on the other hand revealed the presence of deoxygenated blood within the tumor after the ablation due to the destruction of blood vessel network while color Doppler imaging confirmed the blood vessel network destruction within the tumor. The treated area and the presence of red blood cells detected by photoacoustics were further confirmed by the histopathology. This feasibility study demonstrates the potential of high frequency US and PA approach for assessing in-vivo the effect of mechanical HIFU tumor ablation.

© 2017 Optical Society of America

Full Article  |  PDF Article
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2016 (2)

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

2015 (4)

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging,” Theranostics 5(3), 289–301 (2015).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

2014 (5)

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. F. Chu and D. E. Dupuy, “Thermal ablation of tumours: biological mechanisms and advances in therapy,” Nat. Rev. Cancer 14(3), 199–208 (2014).
[Crossref] [PubMed]

M. Alhamami, M. C. Kolios, and J. Tavakkoli, “Photoacoustic detection and optical spectroscopy of high-intensity focused ultrasound-induced thermal lesions in biologic tissue,” Med. Phys. 41(5), 053502 (2014).
[Crossref] [PubMed]

N. Dana, L. Di Biase, A. Natale, S. Emelianov, and R. Bouchard, “In vitro photoacoustic visualization of myocardial ablation lesions,” Heart Rhythm 11(1), 150–157 (2014).
[Crossref] [PubMed]

2013 (4)

Y. S. Hsiao, X. Wang, and C. X. Deng, “Dual-wavelength photoacoustic technique for monitoring tissue status during thermal treatments,” J. Biomed. Opt. 18(6), 067003 (2013).
[Crossref] [PubMed]

K. Daoudi, P. van Es, S. Manohar, and W. Steenbergen, “Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic-ultrasound transmission tomography,” J. Biomed. Opt. 18(11), 116009 (2013).
[Crossref] [PubMed]

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

C. Lutzweiler and D. Razansky, “Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification,” Sensors (Basel) 13(6), 7345–7384 (2013).
[Crossref] [PubMed]

2012 (1)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

2010 (4)

P. V. Chitnis, H.-P. Brecht, R. Su, and A. A. Oraevsky, “Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue,” J. Biomed. Opt. 15(2), 021313 (2010).
[Crossref] [PubMed]

H. Chen, A. A. Brayman, M. R. Bailey, and T. J. Matula, “Blood vessel rupture by cavitation,” Urol. Res. 38(4), 321–326 (2010).
[Crossref] [PubMed]

L. Zhang and Z. B. Wang, “High-intensity focused ultrasound tumor ablation: review of ten years of clinical experience,” Front. Med. China 4(3), 294–302 (2010).
[Crossref] [PubMed]

H. Cui and X. Yang, “In vivo imaging and treatment of solid tumor using integrated photoacoustic imaging and high intensity focused ultrasound system,” Med. Phys. 37(9), 4777–4781 (2010).
[Crossref] [PubMed]

2009 (1)

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

2008 (3)

T. J. Dubinsky, C. Cuevas, M. K. Dighe, O. Kolokythas, and J. H. Hwang, “High-intensity focused ultrasound: current potential and oncologic applications,” AJR Am. J. Roentgenol. 190(1), 191–199 (2008).
[Crossref] [PubMed]

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

2007 (2)

G. T. Haar and C. Coussios, “High intensity focused ultrasound: physical principles and devices,” Int. J. Hyperthermia 23(2), 89–104 (2007).
[Crossref]

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

2006 (3)

J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, “Pulsed cavitational ultrasound therapy for controlled tissue homogenization,” Ultrasound Med. Biol. 32(1), 115–129 (2006).
[Crossref] [PubMed]

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

G. Aus, “Current status of HIFU and cryotherapy in prostate cancer--a review,” Eur. Urol. 50(5), 927–934 (2006).
[Crossref] [PubMed]

2005 (1)

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Abrams, G. D.

J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, “Pulsed cavitational ultrasound therapy for controlled tissue homogenization,” Ultrasound Med. Biol. 32(1), 115–129 (2006).
[Crossref] [PubMed]

Adema, G. J.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

Aglyamov, S.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Alhamami, M.

M. Alhamami, M. C. Kolios, and J. Tavakkoli, “Photoacoustic detection and optical spectroscopy of high-intensity focused ultrasound-induced thermal lesions in biologic tissue,” Med. Phys. 41(5), 053502 (2014).
[Crossref] [PubMed]

Aus, G.

G. Aus, “Current status of HIFU and cryotherapy in prostate cancer--a review,” Eur. Urol. 50(5), 927–934 (2006).
[Crossref] [PubMed]

Bai, J.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Bailey, M. R.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

H. Chen, A. A. Brayman, M. R. Bailey, and T. J. Matula, “Blood vessel rupture by cavitation,” Urol. Res. 38(4), 321–326 (2010).
[Crossref] [PubMed]

Bouchard, R.

N. Dana, L. Di Biase, A. Natale, S. Emelianov, and R. Bouchard, “In vitro photoacoustic visualization of myocardial ablation lesions,” Heart Rhythm 11(1), 150–157 (2014).
[Crossref] [PubMed]

Bouchard, R. R.

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

Brands, P.

Brayman, A. A.

H. Chen, A. A. Brayman, M. R. Bailey, and T. J. Matula, “Blood vessel rupture by cavitation,” Urol. Res. 38(4), 321–326 (2010).
[Crossref] [PubMed]

Brecht, H.-P.

P. V. Chitnis, H.-P. Brecht, R. Su, and A. A. Oraevsky, “Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue,” J. Biomed. Opt. 15(2), 021313 (2010).
[Crossref] [PubMed]

Brinkhuis, M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Cain, C. A.

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, “Pulsed cavitational ultrasound therapy for controlled tissue homogenization,” Ultrasound Med. Biol. 32(1), 115–129 (2006).
[Crossref] [PubMed]

Chen, H.

H. Chen, A. A. Brayman, M. R. Bailey, and T. J. Matula, “Blood vessel rupture by cavitation,” Urol. Res. 38(4), 321–326 (2010).
[Crossref] [PubMed]

Chen, J. C.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Chen, W. S.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Chen, W. Z.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Chitnis, P. V.

P. V. Chitnis, H.-P. Brecht, R. Su, and A. A. Oraevsky, “Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue,” J. Biomed. Opt. 15(2), 021313 (2010).
[Crossref] [PubMed]

Chu, K. F.

K. F. Chu and D. E. Dupuy, “Thermal ablation of tumours: biological mechanisms and advances in therapy,” Nat. Rev. Cancer 14(3), 199–208 (2014).
[Crossref] [PubMed]

Coussios, C.

G. T. Haar and C. Coussios, “High intensity focused ultrasound: physical principles and devices,” Int. J. Hyperthermia 23(2), 89–104 (2007).
[Crossref]

Crum, L. A.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Cuevas, C.

T. J. Dubinsky, C. Cuevas, M. K. Dighe, O. Kolokythas, and J. H. Hwang, “High-intensity focused ultrasound: current potential and oncologic applications,” AJR Am. J. Roentgenol. 190(1), 191–199 (2008).
[Crossref] [PubMed]

Cui, H.

H. Cui and X. Yang, “In vivo imaging and treatment of solid tumor using integrated photoacoustic imaging and high intensity focused ultrasound system,” Med. Phys. 37(9), 4777–4781 (2010).
[Crossref] [PubMed]

Cunitz, B. W.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Dana, N.

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

N. Dana, L. Di Biase, A. Natale, S. Emelianov, and R. Bouchard, “In vitro photoacoustic visualization of myocardial ablation lesions,” Heart Rhythm 11(1), 150–157 (2014).
[Crossref] [PubMed]

Daoudi, K.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. van Es, S. Manohar, and W. Steenbergen, “Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic-ultrasound transmission tomography,” J. Biomed. Opt. 18(11), 116009 (2013).
[Crossref] [PubMed]

den Brok, M. H.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

Deng, C. X.

Y. S. Hsiao, X. Wang, and C. X. Deng, “Dual-wavelength photoacoustic technique for monitoring tissue status during thermal treatments,” J. Biomed. Opt. 18(6), 067003 (2013).
[Crossref] [PubMed]

Dextraze, K. L.

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

Di Biase, L.

N. Dana, L. Di Biase, A. Natale, S. Emelianov, and R. Bouchard, “In vitro photoacoustic visualization of myocardial ablation lesions,” Heart Rhythm 11(1), 150–157 (2014).
[Crossref] [PubMed]

Dighe, M. K.

T. J. Dubinsky, C. Cuevas, M. K. Dighe, O. Kolokythas, and J. H. Hwang, “High-intensity focused ultrasound: current potential and oncologic applications,” AJR Am. J. Roentgenol. 190(1), 191–199 (2008).
[Crossref] [PubMed]

Dubinsky, T. J.

T. J. Dubinsky, C. Cuevas, M. K. Dighe, O. Kolokythas, and J. H. Hwang, “High-intensity focused ultrasound: current potential and oncologic applications,” AJR Am. J. Roentgenol. 190(1), 191–199 (2008).
[Crossref] [PubMed]

Dumont, E.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

Dupuy, D. E.

K. F. Chu and D. E. Dupuy, “Thermal ablation of tumours: biological mechanisms and advances in therapy,” Nat. Rev. Cancer 14(3), 199–208 (2014).
[Crossref] [PubMed]

Eikelenboom, D.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

Eikelenboom, D. C.

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

Emelianov, S.

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

N. Dana, L. Di Biase, A. Natale, S. Emelianov, and R. Bouchard, “In vitro photoacoustic visualization of myocardial ablation lesions,” Heart Rhythm 11(1), 150–157 (2014).
[Crossref] [PubMed]

Emelianov, S. Y.

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Fan, Z.

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

Fowlkes, J. B.

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, “Pulsed cavitational ultrasound therapy for controlled tissue homogenization,” Ultrasound Med. Biol. 32(1), 115–129 (2006).
[Crossref] [PubMed]

Fütterer, J. J.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

Gray, J. P.

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

Haar, G. T.

G. T. Haar and C. Coussios, “High intensity focused ultrasound: physical principles and devices,” Int. J. Hyperthermia 23(2), 89–104 (2007).
[Crossref]

Hall, T. L.

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

Han, Z. H.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Hasan, T.

S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging,” Theranostics 5(3), 289–301 (2015).
[Crossref] [PubMed]

He, G. B.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Heerschap, A.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

Heijblom, M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Hoogenboom, M.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

Hsiao, Y. S.

Y. S. Hsiao, X. Wang, and C. X. Deng, “Dual-wavelength photoacoustic technique for monitoring tissue status during thermal treatments,” J. Biomed. Opt. 18(6), 067003 (2013).
[Crossref] [PubMed]

Hsu, P. H.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Hu, S.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Huang, W. C.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Hulsbergen-van de Kaa, C.

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

Hwang, J. H.

T. J. Dubinsky, C. Cuevas, M. K. Dighe, O. Kolokythas, and J. H. Hwang, “High-intensity focused ultrasound: current potential and oncologic applications,” AJR Am. J. Roentgenol. 190(1), 191–199 (2008).
[Crossref] [PubMed]

Ives, K.

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

Jin, C. B.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Johnston, K.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Khokhlova, T. D.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Khokhlova, V. A.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Klaase, J. M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Kohl, A.

Kolios, M. C.

M. Alhamami, M. C. Kolios, and J. Tavakkoli, “Photoacoustic detection and optical spectroscopy of high-intensity focused ultrasound-induced thermal lesions in biologic tissue,” Med. Phys. 41(5), 053502 (2014).
[Crossref] [PubMed]

Kolokythas, O.

T. J. Dubinsky, C. Cuevas, M. K. Dighe, O. Kolokythas, and J. H. Hwang, “High-intensity focused ultrasound: current potential and oncologic applications,” AJR Am. J. Roentgenol. 190(1), 191–199 (2008).
[Crossref] [PubMed]

Larson, T.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Li, K. Q.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Li, L.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Liu, H. L.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Luke, G. P.

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

Lutzweiler, C.

C. Lutzweiler and D. Razansky, “Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification,” Sensors (Basel) 13(6), 7345–7384 (2013).
[Crossref] [PubMed]

Ma, L.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Maier, F.

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

Mallidi, S.

S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging,” Theranostics 5(3), 289–301 (2015).
[Crossref] [PubMed]

Manohar, S.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

K. Daoudi, P. van Es, S. Manohar, and W. Steenbergen, “Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic-ultrasound transmission tomography,” J. Biomed. Opt. 18(11), 116009 (2013).
[Crossref] [PubMed]

Matula, T. J.

H. Chen, A. A. Brayman, M. R. Bailey, and T. J. Matula, “Blood vessel rupture by cavitation,” Urol. Res. 38(4), 321–326 (2010).
[Crossref] [PubMed]

Milner, T.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Nam, S. Y.

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

Natale, A.

N. Dana, L. Di Biase, A. Natale, S. Emelianov, and R. Bouchard, “In vitro photoacoustic visualization of myocardial ablation lesions,” Heart Rhythm 11(1), 150–157 (2014).
[Crossref] [PubMed]

Oraevsky, A. A.

P. V. Chitnis, H.-P. Brecht, R. Su, and A. A. Oraevsky, “Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue,” J. Biomed. Opt. 15(2), 021313 (2010).
[Crossref] [PubMed]

Park, S.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Parsons, J. E.

J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, “Pulsed cavitational ultrasound therapy for controlled tissue homogenization,” Ultrasound Med. Biol. 32(1), 115–129 (2006).
[Crossref] [PubMed]

Paun, M.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Piras, D.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Rabot, O.

Razansky, D.

C. Lutzweiler and D. Razansky, “Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification,” Sensors (Basel) 13(6), 7345–7384 (2013).
[Crossref] [PubMed]

Ren, X. L.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Roberts, W. W.

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

Schoenfeld, D.

S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging,” Theranostics 5(3), 289–301 (2015).
[Crossref] [PubMed]

Shah, J.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Simon, J. C.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Sokolov, K.

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Starr, F.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Steenbergen, W.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. van Es, S. Manohar, and W. Steenbergen, “Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic-ultrasound transmission tomography,” J. Biomed. Opt. 18(11), 116009 (2013).
[Crossref] [PubMed]

Su, H. B.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Su, R.

P. V. Chitnis, H.-P. Brecht, R. Su, and A. A. Oraevsky, “Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue,” J. Biomed. Opt. 15(2), 021313 (2010).
[Crossref] [PubMed]

Tavakkoli, J.

M. Alhamami, M. C. Kolios, and J. Tavakkoli, “Photoacoustic detection and optical spectroscopy of high-intensity focused ultrasound-induced thermal lesions in biologic tissue,” Med. Phys. 41(5), 053502 (2014).
[Crossref] [PubMed]

Timerman, D.

S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging,” Theranostics 5(3), 289–301 (2015).
[Crossref] [PubMed]

Tisserand, S.

van Amerongen, M. J.

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

van den Berg, P. J.

van den Engh, F. M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

van der Schaaf, M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

van Es, P.

K. Daoudi, P. van Es, S. Manohar, and W. Steenbergen, “Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic-ultrasound transmission tomography,” J. Biomed. Opt. 18(11), 116009 (2013).
[Crossref] [PubMed]

van Hespen, J. C.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

van Leeuwen, T. G.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Veltien, A.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

Wai, Y. Y.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Wang, J. J.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Wang, L.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Wang, L. V.

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Wang, X.

Y. S. Hsiao, X. Wang, and C. X. Deng, “Dual-wavelength photoacoustic technique for monitoring tissue status during thermal treatments,” J. Biomed. Opt. 18(6), 067003 (2013).
[Crossref] [PubMed]

Wang, Y. N.

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Wang, Z. B.

L. Zhang and Z. B. Wang, “High-intensity focused ultrasound tumor ablation: review of ten years of clinical experience,” Front. Med. China 4(3), 294–302 (2010).
[Crossref] [PubMed]

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Wassink, M.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

Watanabe, K.

S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging,” Theranostics 5(3), 289–301 (2015).
[Crossref] [PubMed]

Wesseling, P.

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

Winterroth, F.

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

Wolf, J. S.

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

Wu, F.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Wu, X. Y.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Xie, F. L.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Xu, Z.

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

Yang, X.

H. Cui and X. Yang, “In vivo imaging and treatment of solid tumor using integrated photoacoustic imaging and high intensity focused ultrasound system,” Med. Phys. 37(9), 4777–4781 (2010).
[Crossref] [PubMed]

Yen, T. C.

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Yu, M.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Zhang, J.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Zhang, L.

L. Zhang and Z. B. Wang, “High-intensity focused ultrasound tumor ablation: review of ten years of clinical experience,” Front. Med. China 4(3), 294–302 (2010).
[Crossref] [PubMed]

Zheng, M. J.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Zhou, X. D.

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

Zhu, H.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Zou, J. Z.

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

AJR Am. J. Roentgenol. (1)

T. J. Dubinsky, C. Cuevas, M. K. Dighe, O. Kolokythas, and J. H. Hwang, “High-intensity focused ultrasound: current potential and oncologic applications,” AJR Am. J. Roentgenol. 190(1), 191–199 (2008).
[Crossref] [PubMed]

Eur. Urol. (1)

G. Aus, “Current status of HIFU and cryotherapy in prostate cancer--a review,” Eur. Urol. 50(5), 927–934 (2006).
[Crossref] [PubMed]

Front. Med. China (1)

L. Zhang and Z. B. Wang, “High-intensity focused ultrasound tumor ablation: review of ten years of clinical experience,” Front. Med. China 4(3), 294–302 (2010).
[Crossref] [PubMed]

Heart Rhythm (1)

N. Dana, L. Di Biase, A. Natale, S. Emelianov, and R. Bouchard, “In vitro photoacoustic visualization of myocardial ablation lesions,” Heart Rhythm 11(1), 150–157 (2014).
[Crossref] [PubMed]

Int. J. Hyperthermia (1)

G. T. Haar and C. Coussios, “High intensity focused ultrasound: physical principles and devices,” Int. J. Hyperthermia 23(2), 89–104 (2007).
[Crossref]

J. Biomed. Opt. (4)

P. V. Chitnis, H.-P. Brecht, R. Su, and A. A. Oraevsky, “Feasibility of optoacoustic visualization of high-intensity focused ultrasound-induced thermal lesions in live tissue,” J. Biomed. Opt. 15(2), 021313 (2010).
[Crossref] [PubMed]

J. Shah, S. Park, S. Aglyamov, T. Larson, L. Ma, K. Sokolov, K. Johnston, T. Milner, and S. Y. Emelianov, “Photoacoustic imaging and temperature measurement for photothermal cancer therapy,” J. Biomed. Opt. 13(3), 034024 (2008).
[Crossref] [PubMed]

Y. S. Hsiao, X. Wang, and C. X. Deng, “Dual-wavelength photoacoustic technique for monitoring tissue status during thermal treatments,” J. Biomed. Opt. 18(6), 067003 (2013).
[Crossref] [PubMed]

K. Daoudi, P. van Es, S. Manohar, and W. Steenbergen, “Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic-ultrasound transmission tomography,” J. Biomed. Opt. 18(11), 116009 (2013).
[Crossref] [PubMed]

J. Ther. Ultrasound (1)

M. Hoogenboom, M. J. van Amerongen, D. C. Eikelenboom, M. Wassink, M. H. den Brok, C. Hulsbergen-van de Kaa, E. Dumont, G. J. Adema, A. Heerschap, and J. J. Fütterer, “Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals,” J. Ther. Ultrasound 3(1), 14 (2015).
[Crossref] [PubMed]

J. Ultrasound Med. (1)

X. L. Ren, X. D. Zhou, J. Zhang, G. B. He, Z. H. Han, M. J. Zheng, L. Li, M. Yu, and L. Wang, “Extracorporeal ablation of uterine fibroids with high-intensity focused ultrasound: imaging and histopathologic evaluation,” J. Ultrasound Med. 26(2), 201–212 (2007).
[Crossref] [PubMed]

J. Urol. (1)

W. W. Roberts, T. L. Hall, K. Ives, J. S. Wolf, J. B. Fowlkes, and C. A. Cain, “Pulsed cavitational ultrasound: a noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney,” J. Urol. 175(2), 734–738 (2006).
[Crossref] [PubMed]

Med. Phys. (2)

H. Cui and X. Yang, “In vivo imaging and treatment of solid tumor using integrated photoacoustic imaging and high intensity focused ultrasound system,” Med. Phys. 37(9), 4777–4781 (2010).
[Crossref] [PubMed]

M. Alhamami, M. C. Kolios, and J. Tavakkoli, “Photoacoustic detection and optical spectroscopy of high-intensity focused ultrasound-induced thermal lesions in biologic tissue,” Med. Phys. 41(5), 053502 (2014).
[Crossref] [PubMed]

Nat. Rev. Cancer (1)

K. F. Chu and D. E. Dupuy, “Thermal ablation of tumours: biological mechanisms and advances in therapy,” Nat. Rev. Cancer 14(3), 199–208 (2014).
[Crossref] [PubMed]

NMR Biomed. (1)

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Veltien, M. Wassink, P. Wesseling, E. Dumont, J. J. Fütterer, G. J. Adema, and A. Heerschap, “In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology,” NMR Biomed. 29(6), 721–731 (2016).
[Crossref] [PubMed]

Opt. Express (1)

Photoacoustics (1)

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

T. D. Khokhlova, Y. N. Wang, J. C. Simon, B. W. Cunitz, F. Starr, M. Paun, L. A. Crum, M. R. Bailey, and V. A. Khokhlova, “Ultrasound-guided tissue fractionation by high intensity focused ultrasound in an in vivo porcine liver model,” Proc. Natl. Acad. Sci. U.S.A. 111(22), 8161–8166 (2014).
[Crossref] [PubMed]

Radiology (1)

F. Wu, Z. B. Wang, W. Z. Chen, J. Z. Zou, J. Bai, H. Zhu, K. Q. Li, C. B. Jin, F. L. Xie, and H. B. Su, “Advanced hepatocellular carcinoma: treatment with high-intensity focused ultrasound ablation combined with transcatheter arterial embolization,” Radiology 235(2), 659–667 (2005).
[Crossref] [PubMed]

Sci. Rep. (1)

M. Heijblom, D. Piras, M. Brinkhuis, J. C. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Science (1)

L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

Sensors (Basel) (1)

C. Lutzweiler and D. Razansky, “Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification,” Sensors (Basel) 13(6), 7345–7384 (2013).
[Crossref] [PubMed]

Theranostics (1)

S. Mallidi, K. Watanabe, D. Timerman, D. Schoenfeld, and T. Hasan, “Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging,” Theranostics 5(3), 289–301 (2015).
[Crossref] [PubMed]

Ultrason. Imaging (1)

J. P. Gray, N. Dana, K. L. Dextraze, F. Maier, S. Emelianov, and R. R. Bouchard, “Multi-Wavelength Photoacoustic Visualization of High Intensity Focused Ultrasound Lesions,” Ultrason. Imaging 38(1), 96–112 (2016).
[Crossref] [PubMed]

Ultrasound Med. Biol. (4)

M. Hoogenboom, D. Eikelenboom, M. H. den Brok, A. Heerschap, J. J. Fütterer, and G. J. Adema, “Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects,” Ultrasound Med. Biol. 41(6), 1500–1517 (2015).
[Crossref] [PubMed]

Z. Xu, Z. Fan, T. L. Hall, F. Winterroth, J. B. Fowlkes, and C. A. Cain, “Size measurement of tissue debris particles generated from pulsed ultrasound cavitational therapy-histotripsy,” Ultrasound Med. Biol. 35(2), 245–255 (2009).
[Crossref] [PubMed]

J. E. Parsons, C. A. Cain, G. D. Abrams, and J. B. Fowlkes, “Pulsed cavitational ultrasound therapy for controlled tissue homogenization,” Ultrasound Med. Biol. 32(1), 115–129 (2006).
[Crossref] [PubMed]

H. L. Liu, Y. Y. Wai, W. S. Chen, J. C. Chen, P. H. Hsu, X. Y. Wu, W. C. Huang, T. C. Yen, and J. J. Wang, “Hemorrhage detection during focused-ultrasound induced blood-brain-barrier opening by using susceptibility-weighted magnetic resonance imaging,” Ultrasound Med. Biol. 34(4), 598–606 (2008).
[Crossref] [PubMed]

Urol. Res. (1)

H. Chen, A. A. Brayman, M. R. Bailey, and T. J. Matula, “Blood vessel rupture by cavitation,” Urol. Res. 38(4), 321–326 (2010).
[Crossref] [PubMed]

Other (1)

PRIME, “Preclinical Imaging Centre, Radboudumc” https://www.radboudumc.nl/Research/Organisationofresearch/Departments/cdl/PRIME/Pages/default.aspx .

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Figures (4)

Fig. 1
Fig. 1 Pictures of the HIFU and imaging system used in the experiment, (a) MR compatible animal HIFU system, (b) zoomed image on the 16-channel annular array HIFU transducer used for the ablation, (c) Vevo LAZR 2100 system for high frequency US and PA imaging.
Fig. 2
Fig. 2 High-frequency ultrasound images before (a), (b) and after treatment (c), (d) of mouse 1 and 2 respectively using 40 Mhz ultrasound transducer. (e) and (f) represent the histopathology of one slide of the tumors after treatment with 2 zoomed regions each. The green arrow indicates the fragments of tumor cells, the red arrow indicates liquefied region, yellow arrow indicates non treated tumor region and red blood cells are delineated with a blue dotted line in the zoomed region of panel (e). (g) and (h) are MR images of mouse 1 and 2 respectively, left image is T2W images and right is contrast enhanced images.
Fig. 3
Fig. 3 Ultrasound color Doppler of mouse 1 and 2 before treatment (a) and (b) and after treatment (c) and (d) respectively
Fig. 4
Fig. 4 (a) and (b) pre and post treatment photoacoustic images of mouse 1, (c) and (d) are the corresponding unmixed images using melanin, deoxy and oxy hemoglobin spectra, (e) and (f) are unmixed images of mouse 2 using the same spectra before and after the ablation respectively.

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