Abstract

Delineating brain tumor margin is critical for maximizing tumor removal while sparing adjacent normal tissue for better clinical outcome. We describe the use of moxifloxacin-based two-photon (TP)/coherent anti-Stokes Raman scattering (CARS) combined microscopy for differentiating normal mouse brain tissue from metastatic brain tumor tissue based on histoarchitectural and biochemical differences. Moxifloxacin, an FDA-approved compound, was used to label cells in the brain, and moxifloxacin-based two-photon microscopy (TPM) revealed tumor lesions with significantly high cellular density and invading edges in a metastatic brain tumor model. Besides, label-free CARS microscopy showed diminishing of lipid signal due to the destruction of myelin at the tumor site compared to a normal brain tissue site resulting in a complementary contrast for tumor detection. This study demonstrates that moxifloxacin-based TP/CARS combined microscopy might be advantageous for tumor margin identification in the brain that has been a long-standing challenge in the operating room.

© 2017 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Chemically-selective imaging of brain structures with CARS microscopy

Conor L. Evans, Xiaoyin Xu, Santosh Kesari, X. Sunney Xie, Stephen T.C. Wong, and Geoffrey S. Young
Opt. Express 15(19) 12076-12087 (2007)

Feasibility study of brain tumor delineation using immunolabeled gold nanorods

Kevin Seekell, Spencer Lewis, Christy Wilson, Shuqin Li, Gerald Grant, and Adam Wax
Biomed. Opt. Express 4(11) 2284-2295 (2013)

Multimodal non-linear optical imaging for label-free differentiation of lung cancerous lesions from normal and desmoplastic tissues

Xiaoyun Xu, Jie Cheng, Michael J. Thrall, Zhengfan Liu, Xi Wang, and Stephen T.C. Wong
Biomed. Opt. Express 4(12) 2855-2868 (2013)

References

  • View by:
  • |
  • |
  • |

  1. A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
    [PubMed]
  2. E. C. Kaal, M. J. Taphoorn, and C. J. Vecht, “Symptomatic management and imaging of brain metastases,” J. Neurooncol. 75(1), 15–20 (2005).
    [Crossref] [PubMed]
  3. R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
    [Crossref] [PubMed]
  4. N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
    [Crossref] [PubMed]
  5. N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
    [Crossref] [PubMed]
  6. W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
    [Crossref] [PubMed]
  7. F. K. Albert, M. Forsting, K. Sartor, H. P. Adams, S. Kunze, “Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis,” Neurosurgery 34, 45–60 (1994).
    [Crossref]
  8. P. A. Valdés, D. W. Roberts, F. K. Lu, and A. Golby, “Optical technologies for intraoperative neurosurgical guidance,” Neurosurg. Focus 40(3), E8 (2016).
    [Crossref] [PubMed]
  9. I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
    [Crossref] [PubMed]
  10. Q. T. Nguyen and R. Y. Tsien, “Fluorescence-guided surgery with live molecular navigation--a new cutting edge,” Nat. Rev. Cancer 13(9), 653–662 (2013).
    [Crossref] [PubMed]
  11. B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
    [Crossref] [PubMed]
  12. C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
    [Crossref] [PubMed]
  13. K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
    [Crossref] [PubMed]
  14. F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
    [Crossref] [PubMed]
  15. C. Ricard and F. C. Debarbieux, “Six-color intravital two-photon imaging of brain tumors and their dynamic microenvironment,” Front. Cell. Neurosci. 8, 57 (2014).
    [Crossref] [PubMed]
  16. S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
    [Crossref] [PubMed]
  17. W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
    [Crossref] [PubMed]
  18. G. Thomas, J. van Voskuilen, H. C. Gerritsen, and H. J. Sterenborg, “Advances and challenges in label-free nonlinear optical imaging using two-photon excitation fluorescence and second harmonic generation for cancer research,” J. Photochem. Photobiol. B 141, 128–138 (2014).
    [Crossref] [PubMed]
  19. J. M. Dela Cruz, J. D. McMullen, R. M. Williams, and W. R. Zipfel, “Feasibility of using multiphoton excited tissue autofluorescence for in vivo human histopathology,” Biomed. Opt. Express 1(5), 1320–1330 (2010).
    [Crossref] [PubMed]
  20. C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
    [Crossref] [PubMed]
  21. T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
    [PubMed]
  22. H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
    [Crossref] [PubMed]
  23. C. L. Evans, X. Xu, S. Kesari, X. S. Xie, S. T. Wong, and G. S. Young, “Chemically-selective imaging of brain structures with CARS microscopy,” Opt. Express 15(19), 12076–12087 (2007).
    [Crossref] [PubMed]
  24. M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
    [Crossref] [PubMed]
  25. M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
    [Crossref] [PubMed]
  26. T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
    [Crossref] [PubMed]
  27. D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
    [Crossref] [PubMed]
  28. K. S. Madden, M. L. Zettel, A. K. Majewska, and E. B. Brown, “Brain tumor imaging: live imaging of glioma by two-photon microscopy,” Cold Spring Harb. Protoc. 2013(3), pdb.prot073668 (2013).
    [Crossref] [PubMed]
  29. Y. Fu, T. B. Huff, H. W. Wang, H. Wang, and J. X. Cheng, “Ex vivo and in vivo imaging of myelin fibers in mouse brain by coherent anti-Stokes Raman scattering microscopy,” Opt. Express 16(24), 19396–19409 (2008).
    [Crossref] [PubMed]
  30. S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
    [Crossref] [PubMed]
  31. M. Olivo and B. C. Wilson, “Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy,” Int. J. Oncol. 25(1), 37–45 (2004).
    [PubMed]
  32. W. Stummer, “Fluorescein in brain metastasis and glioma surgery,” Acta Neurochir. (Wien) 157(12), 2199–2200 (2015).
    [Crossref] [PubMed]
  33. F. Van Bambeke and P. M. Tulkens, “Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes,” Drug Saf. 32(5), 359–378 (2009).
    [Crossref] [PubMed]
  34. R. C. Owens and P. G. Ambrose, “Antimicrobial safety: focus on fluoroquinolones,” Clin. Infect. Dis. 41(Suppl 2), S144–S157 (2005).
    [Crossref] [PubMed]
  35. P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
    [Crossref] [PubMed]
  36. L. Qiao, X. Cui, and Y. Li, “Status epilepticus attributed to moxifloxacin in an adolescent patient with spina bifida occulta,” Eur. J. Clin. Pharmacol. 67(1), 103–104 (2011).
    [Crossref] [PubMed]
  37. J. Shi and H. Xu, “Moxifloxacin Induced Seizures -A Case Report,” Iran. J. Public Health 43(9), 1291–1294 (2014).
    [PubMed]

2017 (1)

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

2016 (3)

P. A. Valdés, D. W. Roberts, F. K. Lu, and A. Golby, “Optical technologies for intraoperative neurosurgical guidance,” Neurosurg. Focus 40(3), E8 (2016).
[Crossref] [PubMed]

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

2015 (4)

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

W. Stummer, “Fluorescein in brain metastasis and glioma surgery,” Acta Neurochir. (Wien) 157(12), 2199–2200 (2015).
[Crossref] [PubMed]

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

2014 (3)

C. Ricard and F. C. Debarbieux, “Six-color intravital two-photon imaging of brain tumors and their dynamic microenvironment,” Front. Cell. Neurosci. 8, 57 (2014).
[Crossref] [PubMed]

G. Thomas, J. van Voskuilen, H. C. Gerritsen, and H. J. Sterenborg, “Advances and challenges in label-free nonlinear optical imaging using two-photon excitation fluorescence and second harmonic generation for cancer research,” J. Photochem. Photobiol. B 141, 128–138 (2014).
[Crossref] [PubMed]

J. Shi and H. Xu, “Moxifloxacin Induced Seizures -A Case Report,” Iran. J. Public Health 43(9), 1291–1294 (2014).
[PubMed]

2013 (4)

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

K. S. Madden, M. L. Zettel, A. K. Majewska, and E. B. Brown, “Brain tumor imaging: live imaging of glioma by two-photon microscopy,” Cold Spring Harb. Protoc. 2013(3), pdb.prot073668 (2013).
[Crossref] [PubMed]

Q. T. Nguyen and R. Y. Tsien, “Fluorescence-guided surgery with live molecular navigation--a new cutting edge,” Nat. Rev. Cancer 13(9), 653–662 (2013).
[Crossref] [PubMed]

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

2012 (3)

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

2011 (3)

L. Qiao, X. Cui, and Y. Li, “Status epilepticus attributed to moxifloxacin in an adolescent patient with spina bifida occulta,” Eur. J. Clin. Pharmacol. 67(1), 103–104 (2011).
[Crossref] [PubMed]

N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
[Crossref] [PubMed]

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

2010 (2)

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

J. M. Dela Cruz, J. D. McMullen, R. M. Williams, and W. R. Zipfel, “Feasibility of using multiphoton excited tissue autofluorescence for in vivo human histopathology,” Biomed. Opt. Express 1(5), 1320–1330 (2010).
[Crossref] [PubMed]

2009 (1)

F. Van Bambeke and P. M. Tulkens, “Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes,” Drug Saf. 32(5), 359–378 (2009).
[Crossref] [PubMed]

2008 (1)

2007 (2)

C. L. Evans, X. Xu, S. Kesari, X. S. Xie, S. T. Wong, and G. S. Young, “Chemically-selective imaging of brain structures with CARS microscopy,” Opt. Express 15(19), 12076–12087 (2007).
[Crossref] [PubMed]

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

2006 (1)

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

2005 (4)

E. C. Kaal, M. J. Taphoorn, and C. J. Vecht, “Symptomatic management and imaging of brain metastases,” J. Neurooncol. 75(1), 15–20 (2005).
[Crossref] [PubMed]

H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
[Crossref] [PubMed]

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

R. C. Owens and P. G. Ambrose, “Antimicrobial safety: focus on fluoroquinolones,” Clin. Infect. Dis. 41(Suppl 2), S144–S157 (2005).
[Crossref] [PubMed]

2004 (2)

P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
[Crossref] [PubMed]

M. Olivo and B. C. Wilson, “Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy,” Int. J. Oncol. 25(1), 37–45 (2004).
[PubMed]

2003 (1)

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

2001 (1)

W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
[Crossref] [PubMed]

Agar, N. Y. R.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Ager, E.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Ahn, G.-O.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Ambrose, P. G.

R. C. Owens and P. G. Ambrose, “Antimicrobial safety: focus on fluoroquinolones,” Clin. Infect. Dis. 41(Suppl 2), S144–S157 (2005).
[Crossref] [PubMed]

Ball, P.

P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
[Crossref] [PubMed]

Berger, M. S.

N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
[Crossref] [PubMed]

Bergner, N.

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

Bok, S.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Brown, E. B.

K. S. Madden, M. L. Zettel, A. K. Majewska, and E. B. Brown, “Brain tumor imaging: live imaging of glioma by two-photon microscopy,” Cold Spring Harb. Protoc. 2013(3), pdb.prot073668 (2013).
[Crossref] [PubMed]

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Burke, R. M.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Camarillo, I. G.

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

Camelo-Piragua, S.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Chaichana, K. L.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Cheng, J. X.

Y. Fu, T. B. Huff, H. W. Wang, H. Wang, and J. X. Cheng, “Ex vivo and in vivo imaging of myelin fibers in mouse brain by coherent anti-Stokes Raman scattering microscopy,” Opt. Express 16(24), 19396–19409 (2008).
[Crossref] [PubMed]

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
[Crossref] [PubMed]

Choudhri, S.

P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
[Crossref] [PubMed]

Chung, E.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

Chung, W. K.

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

Collins, D. L.

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

Cornu, P.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Cui, X.

L. Qiao, X. Cui, and Y. Li, “Status epilepticus attributed to moxifloxacin in an adolescent patient with spina bifida occulta,” Eur. J. Clin. Pharmacol. 67(1), 103–104 (2011).
[Crossref] [PubMed]

De Jager, P. L.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Debarbieux, F. C.

C. Ricard and F. C. Debarbieux, “Six-color intravital two-photon imaging of brain tumors and their dynamic microenvironment,” Front. Cell. Neurosci. 8, 57 (2014).
[Crossref] [PubMed]

Dela Cruz, J. M.

Delattre, J. Y.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Denk, W.

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

Duyverman, A. M.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Eichler, A. F.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

Engelman, J. A.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Evans, C. L.

Farrar, C. T.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Fisher-Hubbard, A.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Freudiger, C. W.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Fu, D.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Fu, Y.

Y. Fu, T. B. Huff, H. W. Wang, H. Wang, and J. X. Cheng, “Ex vivo and in vivo imaging of myelin fibers in mouse brain by coherent anti-Stokes Raman scattering microscopy,” Opt. Express 16(24), 19396–19409 (2008).
[Crossref] [PubMed]

H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
[Crossref] [PubMed]

Fukumura, D.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

Garrard, M.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Gerard, I. J.

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

Gerritsen, H. C.

G. Thomas, J. van Voskuilen, H. C. Gerritsen, and H. J. Sterenborg, “Advances and challenges in label-free nonlinear optical imaging using two-photon excitation fluorescence and second harmonic generation for cancer research,” J. Photochem. Photobiol. B 141, 128–138 (2014).
[Crossref] [PubMed]

Gho, Y. S.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Gibbs-Strauss, S.

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

Goel, S.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Golby, A.

P. A. Valdés, D. W. Roberts, F. K. Lu, and A. Golby, “Optical technologies for intraoperative neurosurgical guidance,” Neurosurg. Focus 40(3), E8 (2016).
[Crossref] [PubMed]

Golby, A. J.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Grant, R.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Graus, F.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Grisold, W.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Hall, J. A.

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

Hayashi, M.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Heimans, J.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Helmchen, F.

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

Heth, J. A.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Hiddingh, L.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Hildebrand, J.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Hong, C.-P.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Hoskin, P.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Huang, Y.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Huff, T. B.

Y. Fu, T. B. Huff, H. W. Wang, H. Wang, and J. X. Cheng, “Ex vivo and in vivo imaging of myelin fibers in mouse brain by coherent anti-Stokes Raman scattering microscopy,” Opt. Express 16(24), 19396–19409 (2008).
[Crossref] [PubMed]

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

Hwang, S.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Incio, J.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Jain, R. K.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

Jang, M. H.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Jang, W. H.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Jansen, E. D.

W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
[Crossref] [PubMed]

Jermyn, M.

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

Ji, M.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Johnson, M.

W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
[Crossref] [PubMed]

Johnson, T. D.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Kaal, E. C.

E. C. Kaal, M. J. Taphoorn, and C. J. Vecht, “Symptomatic management and imaging of brain metastases,” J. Neurooncol. 75(1), 15–20 (2005).
[Crossref] [PubMed]

Kalff, R.

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

Kalljo, M.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Kamoun, W.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Kanick, S. C.

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

Kersten-Oertel, M.

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

Kesari, S.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

C. L. Evans, X. Xu, S. Kesari, X. S. Xie, S. T. Wong, and G. S. Young, “Chemically-selective imaging of brain structures with CARS microscopy,” Opt. Express 15(19), 12076–12087 (2007).
[Crossref] [PubMed]

Kim, B.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Kim, K. H.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

Kim, M. J.

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Kim, S.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Kodack, D. P.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

Kolste, K. K.

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

Krafft, C.

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

Krauseneck, P.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Kubin, R.

P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
[Crossref] [PubMed]

Kut, C.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Lau, D.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Le, T. T.

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

Le, V.-H.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Leblond, F.

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

Lee, G.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Lee, J.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Lee, J. H.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

Lee, S.

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Lewis, S.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Li, X.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Li, Y.

L. Qiao, X. Cui, and Y. Li, “Status epilepticus attributed to moxifloxacin in an adolescent patient with spina bifida occulta,” Eur. J. Clin. Pharmacol. 67(1), 103–104 (2011).
[Crossref] [PubMed]

Ligon, K. L.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Lin, W. C.

W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
[Crossref] [PubMed]

Liu, X.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Loeffler, J. S.

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

Lu, F. K.

P. A. Valdés, D. W. Roberts, F. K. Lu, and A. Golby, “Optical technologies for intraoperative neurosurgical guidance,” Neurosurg. Focus 40(3), E8 (2016).
[Crossref] [PubMed]

Lussiez, A.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Madden, K. S.

K. S. Madden, M. L. Zettel, A. K. Majewska, and E. B. Brown, “Brain tumor imaging: live imaging of glioma by two-photon microscopy,” Cold Spring Harb. Protoc. 2013(3), pdb.prot073668 (2013).
[Crossref] [PubMed]

Mahadevan-Jansen, A.

W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
[Crossref] [PubMed]

Maher, C. O.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Mahmood, S.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Majewska, A. K.

K. S. Madden, M. L. Zettel, A. K. Majewska, and E. B. Brown, “Brain tumor imaging: live imaging of glioma by two-photon microscopy,” Cold Spring Harb. Protoc. 2013(3), pdb.prot073668 (2013).
[Crossref] [PubMed]

Marosi, C.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

McDermott, M. W.

N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
[Crossref] [PubMed]

McMullen, J. D.

McVeigh, E. R.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Myung, S.-J.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Nguyen, Q. T.

Q. T. Nguyen and R. Y. Tsien, “Fluorescence-guided surgery with live molecular navigation--a new cutting edge,” Nat. Rev. Cancer 13(9), 653–662 (2013).
[Crossref] [PubMed]

Nichols, M. B.

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

Norton, I.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Olivo, M.

M. Olivo and B. C. Wilson, “Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy,” Int. J. Oncol. 25(1), 37–45 (2004).
[PubMed]

Orringer, D. A.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Ottoboni, L.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Owens, R.

P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
[Crossref] [PubMed]

Owens, R. C.

R. C. Owens and P. G. Ambrose, “Antimicrobial safety: focus on fluoroquinolones,” Clin. Infect. Dis. 41(Suppl 2), S144–S157 (2005).
[Crossref] [PubMed]

Park, J. H.

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

Parsa, A. T.

N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
[Crossref] [PubMed]

Paulsen, K. D.

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

Perry, S. W.

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Petrecca, K.

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

Pfannl, R.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Philbert, M. A.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Pogue, B. W.

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

Polley, M. Y.

N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
[Crossref] [PubMed]

Popp, J.

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

Qiao, L.

L. Qiao, X. Cui, and Y. Li, “Status epilepticus attributed to moxifloxacin in an adolescent patient with spina bifida occulta,” Eur. J. Clin. Pharmacol. 67(1), 103–104 (2011).
[Crossref] [PubMed]

Quiñones-Hinojosa, A.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Ramkissoon, S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Ramkissoon, S. H.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Raza, S. M.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Rehrer, C. W.

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

Reichart, R.

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

Ricard, C.

C. Ricard and F. C. Debarbieux, “Six-color intravital two-photon imaging of brain tumors and their dynamic microenvironment,” Front. Cell. Neurosci. 8, 57 (2014).
[Crossref] [PubMed]

Roberts, D. W.

P. A. Valdés, D. W. Roberts, F. K. Lu, and A. Golby, “Optical technologies for intraoperative neurosurgical guidance,” Neurosurg. Focus 40(3), E8 (2016).
[Crossref] [PubMed]

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

Rodriguez, F. J.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Romeike, B. F.

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

Saar, B. G.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Sagher, O.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Samkoe, K.

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

Sanai, N.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
[Crossref] [PubMed]

Santagata, S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Shi, J.

J. Shi and H. Xu, “Moxifloxacin Induced Seizures -A Case Report,” Iran. J. Public Health 43(9), 1291–1294 (2014).
[PubMed]

Shi, R.

H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
[Crossref] [PubMed]

Siegal, T.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Sims, J. R.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Sirhan, D.

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

Snuderl, M.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

So, P. T. C.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Soffietti, R.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Song, Y.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Spino, C.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Stahlmann, R.

P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
[Crossref] [PubMed]

Sterenborg, H. J.

G. Thomas, J. van Voskuilen, H. C. Gerritsen, and H. J. Sterenborg, “Advances and challenges in label-free nonlinear optical imaging using two-photon excitation fluorescence and second harmonic generation for cancer research,” J. Photochem. Photobiol. B 141, 128–138 (2014).
[Crossref] [PubMed]

Stummer, W.

W. Stummer, “Fluorescein in brain metastasis and glioma surgery,” Acta Neurochir. (Wien) 157(12), 2199–2200 (2015).
[Crossref] [PubMed]

Tannous, B. A.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Taphoorn, M. J.

E. C. Kaal, M. J. Taphoorn, and C. J. Vecht, “Symptomatic management and imaging of brain metastases,” J. Neurooncol. 75(1), 15–20 (2005).
[Crossref] [PubMed]

Tchah, H.

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

Thomas, G.

G. Thomas, J. van Voskuilen, H. C. Gerritsen, and H. J. Sterenborg, “Advances and challenges in label-free nonlinear optical imaging using two-photon excitation fluorescence and second harmonic generation for cancer research,” J. Photochem. Photobiol. B 141, 128–138 (2014).
[Crossref] [PubMed]

Toms, S. A.

W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
[Crossref] [PubMed]

Tsien, R. Y.

Q. T. Nguyen and R. Y. Tsien, “Fluorescence-guided surgery with live molecular navigation--a new cutting edge,” Nat. Rev. Cancer 13(9), 653–662 (2013).
[Crossref] [PubMed]

Tulkens, P. M.

F. Van Bambeke and P. M. Tulkens, “Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes,” Drug Saf. 32(5), 359–378 (2009).
[Crossref] [PubMed]

Valdés, P. A.

P. A. Valdés, D. W. Roberts, F. K. Lu, and A. Golby, “Optical technologies for intraoperative neurosurgical guidance,” Neurosurg. Focus 40(3), E8 (2016).
[Crossref] [PubMed]

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

Van Bambeke, F.

F. Van Bambeke and P. M. Tulkens, “Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes,” Drug Saf. 32(5), 359–378 (2009).
[Crossref] [PubMed]

van Voskuilen, J.

G. Thomas, J. van Voskuilen, H. C. Gerritsen, and H. J. Sterenborg, “Advances and challenges in label-free nonlinear optical imaging using two-photon excitation fluorescence and second harmonic generation for cancer research,” J. Photochem. Photobiol. B 141, 128–138 (2014).
[Crossref] [PubMed]

Vecht, C.

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Vecht, C. J.

E. C. Kaal, M. J. Taphoorn, and C. J. Vecht, “Symptomatic management and imaging of brain metastases,” J. Neurooncol. 75(1), 15–20 (2005).
[Crossref] [PubMed]

Venneti, S.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Waeber, C.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Wang, A. C.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

Wang, H.

Y. Fu, T. B. Huff, H. W. Wang, H. Wang, and J. X. Cheng, “Ex vivo and in vivo imaging of myelin fibers in mouse brain by coherent anti-Stokes Raman scattering microscopy,” Opt. Express 16(24), 19396–19409 (2008).
[Crossref] [PubMed]

H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
[Crossref] [PubMed]

Wang, H. W.

Wang, T.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Webb, W. W.

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

Wei, Y.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Williams, R. M.

Wilson, B. C.

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

M. Olivo and B. C. Wilson, “Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy,” Int. J. Oncol. 25(1), 37–45 (2004).
[PubMed]

Wong, S. T.

Xi, J.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Xie, X. S.

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

C. L. Evans, X. Xu, S. Kesari, X. S. Xie, S. T. Wong, and G. S. Young, “Chemically-selective imaging of brain structures with CARS microscopy,” Opt. Express 15(19), 12076–12087 (2007).
[Crossref] [PubMed]

Xu, H.

J. Shi and H. Xu, “Moxifloxacin Induced Seizures -A Case Report,” Iran. J. Public Health 43(9), 1291–1294 (2014).
[PubMed]

Xu, X.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

C. L. Evans, X. Xu, S. Kesari, X. S. Xie, S. T. Wong, and G. S. Young, “Chemically-selective imaging of brain structures with CARS microscopy,” Opt. Express 15(19), 12076–12087 (2007).
[Crossref] [PubMed]

Yamashita, H.

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Ye, X.

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Yoon, C. J.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

Yoon, Y.

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

Young, G. S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

C. L. Evans, X. Xu, S. Kesari, X. S. Xie, S. T. Wong, and G. S. Young, “Chemically-selective imaging of brain structures with CARS microscopy,” Opt. Express 15(19), 12076–12087 (2007).
[Crossref] [PubMed]

Zeng, Q.

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Zettel, M. L.

K. S. Madden, M. L. Zettel, A. K. Majewska, and E. B. Brown, “Brain tumor imaging: live imaging of glioma by two-photon microscopy,” Cold Spring Harb. Protoc. 2013(3), pdb.prot073668 (2013).
[Crossref] [PubMed]

Zickmund, P.

H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
[Crossref] [PubMed]

Zipfel, W. R.

Acta Neurochir. (Wien) (1)

W. Stummer, “Fluorescein in brain metastasis and glioma surgery,” Acta Neurochir. (Wien) 157(12), 2199–2200 (2015).
[Crossref] [PubMed]

Analyst (Lond.) (1)

N. Bergner, B. F. Romeike, R. Reichart, R. Kalff, C. Krafft, and J. Popp, “Tumor margin identification and prediction of the primary tumor from brain metastases using FTIR imaging and support vector machines,” Analyst (Lond.) 138(14), 3983–3990 (2013).
[Crossref] [PubMed]

Ann. Biomed. Eng. (1)

S. W. Perry, R. M. Burke, and E. B. Brown, “Two-photon and second harmonic microscopy in clinical and translational cancer research,” Ann. Biomed. Eng. 40(2), 277–291 (2012).
[Crossref] [PubMed]

Biomed. Opt. Express (1)

Biophys. J. (1)

H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, “Coherent anti-stokes Raman scattering imaging of axonal myelin in live spinal tissues,” Biophys. J. 89(1), 581–591 (2005).
[Crossref] [PubMed]

Clin. Infect. Dis. (1)

R. C. Owens and P. G. Ambrose, “Antimicrobial safety: focus on fluoroquinolones,” Clin. Infect. Dis. 41(Suppl 2), S144–S157 (2005).
[Crossref] [PubMed]

Clin. Ther. (1)

P. Ball, R. Stahlmann, R. Kubin, S. Choudhri, and R. Owens, “Safety profile of oral and intravenous moxifloxacin: cumulative data from clinical trials and postmarketing studies,” Clin. Ther. 26(7), 940–950 (2004).
[Crossref] [PubMed]

Cold Spring Harb. Protoc. (1)

K. S. Madden, M. L. Zettel, A. K. Majewska, and E. B. Brown, “Brain tumor imaging: live imaging of glioma by two-photon microscopy,” Cold Spring Harb. Protoc. 2013(3), pdb.prot073668 (2013).
[Crossref] [PubMed]

Drug Saf. (1)

F. Van Bambeke and P. M. Tulkens, “Safety profile of the respiratory fluoroquinolone moxifloxacin: comparison with other fluoroquinolones and other antibacterial classes,” Drug Saf. 32(5), 359–378 (2009).
[Crossref] [PubMed]

Eur. J. Clin. Pharmacol. (1)

L. Qiao, X. Cui, and Y. Li, “Status epilepticus attributed to moxifloxacin in an adolescent patient with spina bifida occulta,” Eur. J. Clin. Pharmacol. 67(1), 103–104 (2011).
[Crossref] [PubMed]

Eur. J. Neurol. (1)

R. Soffietti, P. Cornu, J. Y. Delattre, R. Grant, F. Graus, W. Grisold, J. Heimans, J. Hildebrand, P. Hoskin, M. Kalljo, P. Krauseneck, C. Marosi, T. Siegal, and C. Vecht, “EFNS Guidelines on diagnosis and treatment of brain metastases: report of an EFNS Task Force,” Eur. J. Neurol. 13(7), 674–681 (2006).
[Crossref] [PubMed]

Front. Cell. Neurosci. (1)

C. Ricard and F. C. Debarbieux, “Six-color intravital two-photon imaging of brain tumors and their dynamic microenvironment,” Front. Cell. Neurosci. 8, 57 (2014).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

B. W. Pogue, S. Gibbs-Strauss, P. A. Valdés, K. Samkoe, D. W. Roberts, and K. D. Paulsen, “Review of Neurosurgical Fluorescence Imaging Methodologies,” IEEE J. Sel. Top. Quantum Electron. 16(3), 493–505 (2010).
[Crossref] [PubMed]

Int. J. Oncol. (1)

M. Olivo and B. C. Wilson, “Mapping ALA-induced PPIX fluorescence in normal brain and brain tumour using confocal fluorescence microscopy,” Int. J. Oncol. 25(1), 37–45 (2004).
[PubMed]

Iran. J. Public Health (1)

J. Shi and H. Xu, “Moxifloxacin Induced Seizures -A Case Report,” Iran. J. Public Health 43(9), 1291–1294 (2014).
[PubMed]

J. Biomed. Opt. (1)

K. K. Kolste, S. C. Kanick, P. A. Valdés, M. Jermyn, B. C. Wilson, D. W. Roberts, K. D. Paulsen, and F. Leblond, “Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance,” J. Biomed. Opt. 20(2), 026002 (2015).
[Crossref] [PubMed]

J. Neurooncol. (1)

E. C. Kaal, M. J. Taphoorn, and C. J. Vecht, “Symptomatic management and imaging of brain metastases,” J. Neurooncol. 75(1), 15–20 (2005).
[Crossref] [PubMed]

J. Neurosurg. (1)

N. Sanai, M. Y. Polley, M. W. McDermott, A. T. Parsa, and M. S. Berger, “An extent of resection threshold for newly diagnosed glioblastomas,” J. Neurosurg. 115(1), 3–8 (2011).
[Crossref] [PubMed]

J. Photochem. Photobiol. B (1)

G. Thomas, J. van Voskuilen, H. C. Gerritsen, and H. J. Sterenborg, “Advances and challenges in label-free nonlinear optical imaging using two-photon excitation fluorescence and second harmonic generation for cancer research,” J. Photochem. Photobiol. B 141, 128–138 (2014).
[Crossref] [PubMed]

Lab. Invest. (1)

C. W. Freudiger, R. Pfannl, D. A. Orringer, B. G. Saar, M. Ji, Q. Zeng, L. Ottoboni, Y. Wei, C. Waeber, J. R. Sims, P. L. De Jager, O. Sagher, M. A. Philbert, X. Xu, S. Kesari, X. S. Xie, and G. S. Young, “Multicolored stain-free histopathology with coherent Raman imaging,” Lab. Invest. 92(10), 1492–1502 (2012).
[Crossref] [PubMed]

Med. Image Anal. (1)

I. J. Gerard, M. Kersten-Oertel, K. Petrecca, D. Sirhan, J. A. Hall, and D. L. Collins, “Brain shift in neuronavigation of brain tumors: A review,” Med. Image Anal. 35, 403–420 (2017).
[Crossref] [PubMed]

Mol. Imaging (1)

T. T. Le, C. W. Rehrer, T. B. Huff, M. B. Nichols, I. G. Camarillo, and J. X. Cheng, “Nonlinear optical imaging to evaluate the impact of obesity on mammary gland and tumor stroma,” Mol. Imaging 6(3), 205–211 (2007).
[PubMed]

Nat. Biotechnol. (1)

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

Nat. Methods (1)

F. Helmchen and W. Denk, “Deep tissue two-photon microscopy,” Nat. Methods 2(12), 932–940 (2005).
[Crossref] [PubMed]

Nat. Rev. Cancer (1)

Q. T. Nguyen and R. Y. Tsien, “Fluorescence-guided surgery with live molecular navigation--a new cutting edge,” Nat. Rev. Cancer 13(9), 653–662 (2013).
[Crossref] [PubMed]

Nat. Rev. Clin. Oncol. (1)

A. F. Eichler, E. Chung, D. P. Kodack, J. S. Loeffler, D. Fukumura, and R. K. Jain, “The biology of brain metastases-translation to new therapies,” Nat. Rev. Clin. Oncol. 8(6), 344–356 (2011).
[PubMed]

Neurosurg. Focus (1)

P. A. Valdés, D. W. Roberts, F. K. Lu, and A. Golby, “Optical technologies for intraoperative neurosurgical guidance,” Neurosurg. Focus 40(3), E8 (2016).
[Crossref] [PubMed]

Opt. Express (2)

Photochem. Photobiol. (1)

W. C. Lin, S. A. Toms, M. Johnson, E. D. Jansen, and A. Mahadevan-Jansen, “In vivo brain tumor demarcation using optical spectroscopy,” Photochem. Photobiol. 73(4), 396–402 (2001).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

D. P. Kodack, E. Chung, H. Yamashita, J. Incio, A. M. Duyverman, Y. Song, C. T. Farrar, Y. Huang, E. Ager, W. Kamoun, S. Goel, M. Snuderl, A. Lussiez, L. Hiddingh, S. Mahmood, B. A. Tannous, A. F. Eichler, D. Fukumura, J. A. Engelman, and R. K. Jain, “Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases,” Proc. Natl. Acad. Sci. U.S.A. 109(45), E3119–E3127 (2012).
[Crossref] [PubMed]

Sci. Rep. (2)

T. Wang, W. H. Jang, S. Lee, C. J. Yoon, J. H. Lee, B. Kim, S. Hwang, C.-P. Hong, Y. Yoon, G. Lee, V.-H. Le, S. Bok, G.-O. Ahn, J. Lee, Y. S. Gho, E. Chung, S. Kim, M. H. Jang, S.-J. Myung, M. J. Kim, P. T. C. So, and K. H. Kim, “Moxifloxacin: Clinically compatible contrast agent for multiphoton imaging,” Sci. Rep. 6, 27142 (2016).
[Crossref] [PubMed]

S. Lee, J. H. Lee, J. H. Park, Y. Yoon, W. K. Chung, H. Tchah, M. J. Kim, and K. H. Kim, “In vivo 3D measurement of moxifloxacin and gatifloxacin distributions in the mouse cornea using multiphoton microscopy,” Sci. Rep. 6, 25339 (2016).
[Crossref] [PubMed]

Sci. Transl. Med. (3)

M. Ji, S. Lewis, S. Camelo-Piragua, S. H. Ramkissoon, M. Snuderl, S. Venneti, A. Fisher-Hubbard, M. Garrard, D. Fu, A. C. Wang, J. A. Heth, C. O. Maher, N. Sanai, T. D. Johnson, C. W. Freudiger, O. Sagher, X. S. Xie, and D. A. Orringer, “Detection of human brain tumor infiltration with quantitative stimulated Raman scattering microscopy,” Sci. Transl. Med. 7(309), 309ra163 (2015).
[Crossref] [PubMed]

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

C. Kut, K. L. Chaichana, J. Xi, S. M. Raza, X. Ye, E. R. McVeigh, F. J. Rodriguez, A. Quiñones-Hinojosa, and X. Li, “Detection of human brain cancer infiltration ex vivo and in vivo using quantitative optical coherence tomography,” Sci. Transl. Med. 7(292), 292ra100 (2015).
[Crossref] [PubMed]

Other (1)

F. K. Albert, M. Forsting, K. Sartor, H. P. Adams, S. Kunze, “Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis,” Neurosurgery 34, 45–60 (1994).
[Crossref]

Supplementary Material (2)

NameDescription
» Visualization 1: MP4 (4185 KB)      Moxifloxacin-based TPM image of metastatic brain tumor. Left: moxifloxacin fluorescence channel, Right: Red fluorescence channel.
» Visualization 2: MP4 (3263 KB)      Moxifloxacin-based TPM image of contralateral hemisphere of the metastatic brain tumor model. Left: moxifloxacin fluorescence channel, Right: Red fluorescence channel.

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (8)

Fig. 1
Fig. 1 Schematic of the TP/CARS combined microscopic system. The system uses Ti:Sapphire and OPO to produce 808 nm and 1049 nm beams as the pump and Stokes beams. Moxifloxacin signal and CARS signal are collected backward using objective lens and two photomultiplier tubes. SBS: beam splitter; OPO: optical parametric oscillator; DL1, DL2: delay lines; DM1, DM2, DM3: dichroic mirror; F1: 3nm narrow bandpass filter; F2, F3: detection bandpass filter; L1, L2, L3: lens; PMT: photomultiplier tube.
Fig. 2
Fig. 2 Development of metastatic brain tumor model with a calvarial door (A) Image of an anesthetized C57BL/6 mouse. (B-D) Hair removal and preparation of the surgical site. (E) Incision of the scalp tissue. (F) Marking a rectangle on the left parietal lobe. (G) Making grooves along the edges of the rectangle with a dental drill. (H) Opened state of the calvarial door. Inset: magnified image of calvarial door. (I) Intracerebral injection of cancer cells with 28-gauge needle Hamilton syringe.
Fig. 3
Fig. 3 TP/CARS microscopic images of hippocampus and cerebral cortex in normal mouse after application of moxifloxacin. Hippocampal images by (A) TPM and (B) CARS microscopy. (C) Hematoxylin and eosin (H & E) stained image of corresponding hippocampus tissue. Subcortical white matter with (D) TPM, (E) CARS and (F) H & E stained tissue image. Cellular components and neural fibers are visible in TPM, while myelinated neural fiber was dominantly imaged in CARS images.
Fig. 4
Fig. 4 Mosaic images with TP/CARS microscopy at the vicinity of a metastatic brain tumor. (A) TP image showed significantly higher cellular density region in the left side of white-dotted line. (B) CARS image showed decreased signal in the left side of blue-dotted line. (C) Hematoxylin and eosin (H & E) stained tissue image showed tumor cells (red arrow head) in the left side of red-dotted line. Immune cells were infiltrated to tumor and peritumoral areas (blue arrows).
Fig. 5
Fig. 5 Moxifloxacin-based TPM image of mouse brain that contains metastatic tumor. (A) SL4-DsRed tumor was mainly located ln left cerebral hemisphere. Red 3 × 3 rectangular region was imaged with TPM. (B) TPM image after topically treated moxifloxacin (green). (C) TPM Red fluorescence image confirming by Ds-Red labeled cancer cells. (D) Merged fluorescence image with moxifloxacin and SL4-DsRed. (E) Four regions of interest (ROIs) are magnified: (F) Multiple cellular bodies were detected in hippocampus. (G) Round, condensed cellular structure was shown. (H) Tumor lesion showed high cellular density. (I) Border of tumor and normal tissue. The cellular density of tumor area was significantly higher than adjacent normal tissue.
Fig. 6
Fig. 6 Histologic characteristics of metastatic brain tumor.(A) H & E staining showed high cellular density tumor cells invading adjacent normal brain tissue (100X). (B) Magnified image showed perivascular growth of metastatic tumor cells along blood vessels evidenced by red blood cells (230X). (C) Magnified image of center of tumor lesion (230X). (D) Hippocampus image in the contralateral normal brain tissue (230X).
Fig. 7
Fig. 7 A strip of images with TP/CARS microscopy at the vicinity of a metastatic brain tumor. (A) TP image showed significantly higher cellular density in tumor region than adjacent normal brain tissue. Numerous cellular body was identified in tumor tissue, while few cellular bodies were shown in adjacent normal tissue. Tumor margins was clearly defined as yellow dotted line. (B) CARS image showed high signal in adjacent normal brain tissue than tumor tissue. Tumor margins was clearly defined as yellow dotted line.
Fig. 8
Fig. 8 Moxifloxacin-based TPM image in the contralateral hemisphere of the metastatic brain tumor model. (A) Blue 3 × 3 rectangular lesion were imaged with TPM. (B) TPM image after topically treated moxifloxacin (green). (C) Ds-Red labeled cancer cells were detected with TPM. (D) Merged fluorescence image with moxifloxacin and SL4-DsRed showed metastases of tumor cell to contralateral cerebral hemisphere. (E) Four regions of interest (ROI) are magnified. (F) Multiple cellular bodies were visible. (G) Characteristic cellular array of hippocampus was noticeable. (H) Perivascular tumor growth was identified and confirmed in red fluorescence channel. (I) Border of tumor and normal tissue. High cellular density was identified in tumor area than normal adjacent brain tissue.

Metrics