Abstract

We present the scattering properties of mouse brain using multispectral diffraction phase microscopy. Typical diffraction phase microscopy was incorporated with the broadband light source which offers the measurement of the scattering coefficient and anisotropy in the spectral range of 550-900 nm. The regional analysis was performed for both the myeloarchitecture and cytoarchitecture of the brain tissue. Our results clearly evaluate the multispectral scattering properties in the olfactory bulb and corpus callosum. The scattering coefficient measured in the corpus callosum is about four times higher than in the olfactory bulb. It also indicates that it is feasible to realize the quantitative phase microscope in near infrared region for thick brain tissue imaging.

© 2017 Optical Society of America

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References

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    [Crossref] [PubMed]

2016 (3)

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
[Crossref] [PubMed]

2014 (2)

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

2013 (5)

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
[Crossref] [PubMed]

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

2012 (1)

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

2011 (4)

2010 (1)

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

2009 (1)

2008 (3)

A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
[Crossref] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

2006 (2)

A. W. Toga, P. M. Thompson, S. Mori, K. Amunts, and K. Zilles, “Towards multimodal atlases of the human brain,” Nat. Rev. Neurosci. 7(12), 952–966 (2006).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

2005 (3)

1994 (1)

P. E. Roland and K. Zilles, “Brain atlases--a new research tool,” Trends Neurosci. 17(11), 458–467 (1994).
[Crossref] [PubMed]

Akkin, T.

Amunts, K.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

A. W. Toga, P. M. Thompson, S. Mori, K. Amunts, and K. Zilles, “Towards multimodal atlases of the human brain,” Nat. Rev. Neurosci. 7(12), 952–966 (2006).
[Crossref] [PubMed]

Andreasson, K. I.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Antaris, A. L.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Arganda-Carreras, I.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

Atochin, D. N.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Badizadegan, K.

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

Bahlmann, K.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

Balla, A.

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

Bazin, P.-L.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Best-Popescu, C.

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
[Crossref] [PubMed]

Bhaduri, B.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Bludau, S.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Boppart, S. A.

Borgeat, L.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Boss, D.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Bou-Reslan, H.

A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
[Crossref] [PubMed]

Carano, R. A.

A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
[Crossref] [PubMed]

Cense, B.

Chang, J.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Chen, C.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Choi, W.

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

Clark, C. G.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Colomb, T.

Cotte, Y.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Cuche, E.

D’Arceuil, H. E.

A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
[Crossref] [PubMed]

Dai, H.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Dasari, R. R.

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

de Boer, J. F.

de Crespigny, A.

A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
[Crossref] [PubMed]

Decker, K.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Depeursinge, C.

Diao, S.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Dibb, R.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Dickscheid, T.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Ding, H.

Edwards, C.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Emery, Y.

Evans, A. C.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Feld, M. S.

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
[Crossref] [PubMed]

Gillette, M. U.

Goddard, L. L.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Gong, H.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Hibi, T.

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

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G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Horton, N. G.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
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G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
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Jacques, S. L.

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
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Jeong, Y.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

Johnson, G. A.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Joo, C.

Jourdain, P.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Jung, J.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

Jung, W.

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
[Crossref] [PubMed]

Kadiri, L. R.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
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E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
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R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

Kim, K.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

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T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
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E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
[Crossref] [PubMed]

Kobat, D.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Kötter, R.

O. Sporns, G. Tononi, and R. Kötter, “The human connectome: A structural description of the human brain,” PLOS Comput. Biol. 1(4), e42 (2005).
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Kozawa, Y.

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
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G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Lee, E.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

Lee, M.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

Lee, S.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

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K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
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K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Li, A.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Li, W.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Liang, X.

Lippert, T.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Liu, C.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
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Liu, Q.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Luo, Q.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
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Magistretti, P.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Magistretti, P. J.

Marquet, P.

Millet, L.

Min, E.

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
[Crossref] [PubMed]

Mir, M.

Mohlberg, H.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
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Mori, S.

A. W. Toga, P. M. Thompson, S. Mori, K. Amunts, and K. Zilles, “Towards multimodal atlases of the human brain,” Nat. Rev. Neurosci. 7(12), 952–966 (2006).
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Nemoto, T.

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
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Nguyen, F.

H. Ding, F. Nguyen, S. A. Boppart, and G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
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H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
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Nguyen, T. H.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
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A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
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Oros-Peusquens, A.-M.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
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Osten, P.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
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Park, B. H.

Park, Y.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
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G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
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Pavillon, N.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
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Pham, H.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
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Phillips, H.

A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
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Popescu, G.

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
[Crossref] [PubMed]

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
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Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
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Z. Wang, L. Millet, M. Mir, H. Ding, S. Unarunotai, J. Rogers, M. U. Gillette, and G. Popescu, “Spatial light interference microscopy (SLIM),” Opt. Express 19(2), 1016–1026 (2011).
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Z. Wang, H. Ding, and G. Popescu, “Scattering-phase theorem,” Opt. Lett. 36(7), 1215–1217 (2011).
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H. Ding, Z. Wang, X. Liang, S. A. Boppart, K. Tangella, and G. Popescu, “Measuring the scattering parameters of tissues from quantitative phase imaging of thin slices,” Opt. Lett. 36(12), 2281–2283 (2011).
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H. Ding, F. Nguyen, S. A. Boppart, and G. Popescu, “Optical properties of tissues quantified by Fourier-transform light scattering,” Opt. Lett. 34(9), 1372–1374 (2009).
[Crossref] [PubMed]

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
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G. Popescu, T. Ikeda, R. R. Dasari, and M. S. Feld, “Diffraction phase microscopy for quantifying cell structure and dynamics,” Opt. Lett. 31(6), 775–777 (2006).
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Ragan, T.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
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Rogers, J.

Roland, P. E.

P. E. Roland and K. Zilles, “Brain atlases--a new research tool,” Trends Neurosci. 17(11), 458–467 (1994).
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Rousseau, M.-É.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Sato, A.

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

Sato, S.

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

Sawada, K.

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

Schaffer, C. B.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Seung, H. S.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

Shah, N. J.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
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Sporns, O.

O. Sporns, G. Tononi, and R. Kötter, “The human connectome: A structural description of the human brain,” PLOS Comput. Biol. 1(4), e42 (2005).
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Sutin, J.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
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Tangella, K.

Taranda, J.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
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Thompson, P. M.

A. W. Toga, P. M. Thompson, S. Mori, K. Amunts, and K. Zilles, “Towards multimodal atlases of the human brain,” Nat. Rev. Neurosci. 7(12), 952–966 (2006).
[Crossref] [PubMed]

Toga, A. W.

A. W. Toga, P. M. Thompson, S. Mori, K. Amunts, and K. Zilles, “Towards multimodal atlases of the human brain,” Nat. Rev. Neurosci. 7(12), 952–966 (2006).
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Tononi, G.

O. Sporns, G. Tononi, and R. Kötter, “The human connectome: A structural description of the human brain,” PLOS Comput. Biol. 1(4), e42 (2005).
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Toy, F.

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

Unarunotai, S.

Venkataraju, K. U.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

Wang, K.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Wang, Q.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Wang, Z.

Wei, H.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Wise, F. W.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

Wu, J.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Xie, L.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Xu, C.

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
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Yan, C.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Yokoyama, H.

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

Yoon, J.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

Yu, H.

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
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Zeng, S.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Zhang, B.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Zhang, Y.

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Zhao, S.

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Zhou, R.

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Zilles, K.

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

A. W. Toga, P. M. Thompson, S. Mori, K. Amunts, and K. Zilles, “Towards multimodal atlases of the human brain,” Nat. Rev. Neurosci. 7(12), 952–966 (2006).
[Crossref] [PubMed]

P. E. Roland and K. Zilles, “Brain atlases--a new research tool,” Trends Neurosci. 17(11), 458–467 (1994).
[Crossref] [PubMed]

Adv. Opt. Photonics (1)

B. Bhaduri, C. Edwards, H. Pham, R. Zhou, T. H. Nguyen, L. L. Goddard, and G. Popescu, “Diffraction phase microscopy: principles and applications in materials and life sciences,” Adv. Opt. Photonics 6(1), 57–119 (2014).
[Crossref]

Blood Cells Mol. Dis. (1)

G. Popescu, Y. Park, W. Choi, R. R. Dasari, M. S. Feld, and K. Badizadegan, “Imaging red blood cell dynamics by quantitative phase microscopy,” Blood Cells Mol. Dis. 41(1), 10–16 (2008).
[Crossref] [PubMed]

J. Biomed. Opt. (1)

Z. Wang, K. Tangella, A. Balla, and G. Popescu, “Tissue refractive index as marker of disease,” J. Biomed. Opt. 16(11), 116017 (2011).
[Crossref] [PubMed]

J. Neurosci. Methods (1)

A. de Crespigny, H. Bou-Reslan, M. C. Nishimura, H. Phillips, R. A. Carano, and H. E. D’Arceuil, “3D micro-CT imaging of the postmortem brain,” J. Neurosci. Methods 171(2), 207–213 (2008).
[Crossref] [PubMed]

Nat. Methods (1)

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

Nat. Photonics (3)

Y. Cotte, F. Toy, P. Jourdain, N. Pavillon, D. Boss, P. Magistretti, P. Marquet, and C. Depeursinge, “Marker-free phase nanoscopy,” Nat. Photonics 7(2), 113–117 (2013).
[Crossref]

N. G. Horton, K. Wang, D. Kobat, C. G. Clark, F. W. Wise, C. B. Schaffer, and C. Xu, “In vivo three-photon microscopy of subcortical structures within an intact mouse brain,” Nat. Photonics 7(3), 205–209 (2013).
[Crossref] [PubMed]

G. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, C. J. Kuo, and H. Dai, “Through-skull fluorescence imaging of the brain in a new near-infrared window,” Nat. Photonics 8(9), 723–730 (2014).
[Crossref] [PubMed]

Nat. Rev. Neurosci. (1)

A. W. Toga, P. M. Thompson, S. Mori, K. Amunts, and K. Zilles, “Towards multimodal atlases of the human brain,” Nat. Rev. Neurosci. 7(12), 952–966 (2006).
[Crossref] [PubMed]

Neuroimage (1)

H. Wei, L. Xie, R. Dibb, W. Li, K. Decker, Y. Zhang, G. A. Johnson, and C. Liu, “Imaging whole-brain cytoarchitecture of mouse with MRI-based quantitative susceptibility mapping,” Neuroimage 137, 107–115 (2016).
[Crossref] [PubMed]

Opt. Express (1)

Opt. Lett. (6)

Phys. Med. Biol. (1)

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
[Crossref] [PubMed]

Phys. Rev. Lett. (1)

H. Ding, Z. Wang, F. Nguyen, S. A. Boppart, and G. Popescu, “Fourier transform light scattering of inhomogeneous and dynamic structures,” Phys. Rev. Lett. 101(23), 238102 (2008).
[Crossref] [PubMed]

PLOS Comput. Biol. (1)

O. Sporns, G. Tononi, and R. Kötter, “The human connectome: A structural description of the human brain,” PLOS Comput. Biol. 1(4), e42 (2005).
[Crossref] [PubMed]

Sci. Rep. (3)

M. Lee, E. Lee, J. Jung, H. Yu, K. Kim, J. Yoon, S. Lee, Y. Jeong, and Y. Park, “Label-free optical quantification of structural alterations in Alzheimer’s disease,” Sci. Rep. 6, 31034 (2016).
[Crossref] [PubMed]

E. Min, M. E. Kandel, C. J. Ko, G. Popescu, W. Jung, and C. Best-Popescu, “Label-free, multi-scale imaging of ex-vivo mouse brain using spatial light interference microscopy,” Sci. Rep. 6, 39667 (2016).
[Crossref] [PubMed]

R. Kawakami, K. Sawada, A. Sato, T. Hibi, Y. Kozawa, S. Sato, H. Yokoyama, and T. Nemoto, “Visualizing hippocampal neurons with in vivo two-photon microscopy using a 1030 nm picosecond pulse laser,” Sci. Rep. 3, 1014 (2013).
[Crossref] [PubMed]

Science (2)

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-optical sectioning tomography to obtain a high-resolution atlas of the mouse brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

K. Amunts, C. Lepage, L. Borgeat, H. Mohlberg, T. Dickscheid, M.-É. Rousseau, S. Bludau, P.-L. Bazin, L. B. Lewis, A.-M. Oros-Peusquens, N. J. Shah, T. Lippert, K. Zilles, and A. C. Evans, “BigBrain: an ultrahigh-resolution 3D human brain model,” Science 340(6139), 1472–1475 (2013).
[Crossref] [PubMed]

Trends Neurosci. (1)

P. E. Roland and K. Zilles, “Brain atlases--a new research tool,” Trends Neurosci. 17(11), 458–467 (1994).
[Crossref] [PubMed]

Other (1)

G. Popescu, Quantitative Phase Imaging of Cells and Tissues (McGraw Hill Professional, 2011).

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Figures (5)

Fig. 1
Fig. 1 Schematic of multispectral diffraction phase microscopy (MS-DPM). The DPM module is attached to the inverted bright field microscopy. The optical light source has multiple spectral bands. The broadband light source passes through optical filter (OF) that has tuning range of 550-900 nm and bandwidth of 6-14 nm. The light is scattered by tissue sample and collected by objective lens (OL). Off-axis geometric DPM module is equipped after image plane of bright field microscope, which is composed of diffraction grating (DG), two lenses (L1 and L2) having focal length of f1 and f2, pinhole (P) and camera. The diffraction grating is placed at the image plane that equal to the focal plane of tube lens (TL). In DPM module, the image field is interfered with plane wave and the interference pattern is detected with camera.
Fig. 2
Fig. 2 Measurement of the scattering coefficient in the olfactory bulb using MS-DPM data. Phase variance and scattering coefficient obtained in the region of olfactory bulb and its subregions (a): cell body (b) and axon/dendrites (c). The phase variance is plotted using box plot. The box covers the 25–75% percentiles, and the maximum length of whisker is 2 times the standard deviation. The scattering coefficient is measured by using scattering-phase theorem, as described in text.
Fig. 3
Fig. 3 MS-DPM images of the corpus callosum (a) and the corresponding graphs of phase variance (b) and scattering coefficient (c).
Fig. 4
Fig. 4 Analysis of anisotropy vs. wavelengths in brain tissue using MS-DPM data: olfactory bulb (a-c) and corpus callosum (d-f). The angular scattering intensity (a, d), graphs of scattering intensity as a function of scattering angle (b, e), and anisotropy graph as a function of wavelength (c, f).
Fig. 5
Fig. 5 MS-DPM images of brain tissue of thickness 12 µm (a), 14 µm (b), and 16 µm (c), and corresponding graphs of scattering coefficient and anisotropy as a function of wavelength.

Equations (2)

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μ s = Δ Ø 2 ( r ) r L
g=1 1 2 k 0 2 | [ Ø( r ) ] | 2 r Δ Ø 2 ( r ) r 2 ,

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