Abstract

Normal tissue radiation toxicities are evaluated subjectively and cannot predict the development of severe side-effects. Using a hand-held diffuse reflectance optical spectroscopy probe, we measured optical parameters in mouse skin 1-4 days after irradiation. Using a radiation toxicity model and a therapeutic mitigator described previously [BMC Cancer 14, 614 (2014)], we found that hemoglobin (Hb) levels increased sharply 24 h after irradiation only in the irradiated group without the mitigator. This group also had the largest peak wound areas after 14 days. We conclude that increased Hb one day after skin irradiation predicts the severity of the subsequent irradiation-induced wound.

© 2017 Optical Society of America

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  4. J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
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    [Crossref] [PubMed]
  6. D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  24. G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
    [Crossref] [PubMed]
  25. D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
    [Crossref] [PubMed]
  26. W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
    [Crossref] [PubMed]
  27. R. Noble-Adams, “Radiation-induced skin reactions. 3: Evaluating the RISRAS,” Br. J. Nurs. 8(19), 1305–1312 (1999).
    [Crossref] [PubMed]
  28. J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
    [Crossref] [PubMed]

2016 (2)

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

2015 (1)

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

2014 (4)

D. Yohan, A. Kim, E. Korpela, S. Liu, C. Niu, B. C. Wilson, and L. C. Chin, “Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy,” Biomed. Opt. Express 5(5), 1309–1320 (2014).
[Crossref] [PubMed]

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

P. M. Herst, N. C. Bennett, A. E. Sutherland, R. I. Peszynski, D. B. Paterson, and M. L. Jasperse, “Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients,” Radiother. Oncol. 110(1), 137–143 (2014).
[Crossref] [PubMed]

2013 (1)

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

2012 (3)

J. L. Ryan, “Ionizing radiation: the good, the bad, and the ugly,” J. Invest. Dermatol. 132(3), 985–993 (2012).
[Crossref] [PubMed]

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

B. G. Douglas and J. F. Fowler, “The effect of multiple small doses of X rays on skin reactions in the mouse and a basic interpretation. 1976,” Radiat. Res. 178(2), AV125–AV138 (2012).
[Crossref] [PubMed]

2011 (1)

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

2010 (3)

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

A. Kim, M. Roy, F. Dadani, and B. C. Wilson, “A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients,” Opt. Express 18(6), 5580–5594 (2010).
[Crossref] [PubMed]

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

2009 (3)

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

2007 (1)

G. N. Stamatas and N. Kollias, “In vivo documentation of cutaneous inflammation using spectral imaging,” J. Biomed. Opt. 12(5), 051603 (2007).
[Crossref] [PubMed]

2006 (1)

M. Woo and R. Nordal, “Commissioning and evaluation of a new commercial small rodent x-ray irradiator,” Biomed Imaging Interv J 2(1), e10 (2006).
[Crossref] [PubMed]

2004 (1)

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

2003 (1)

2002 (1)

D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
[Crossref] [PubMed]

2001 (1)

S. Smesny, S. Riemann, S. Riehemann, M. E. Bellemann, and H. Sauer, “Quantitative measurement of induced skin reddening using optical reflection spectroscopy--methodology and clinical application,” Biomed. Tech. (Berl.) 46(10), 280–286 (2001).
[Crossref] [PubMed]

1999 (1)

R. Noble-Adams, “Radiation-induced skin reactions. 3: Evaluating the RISRAS,” Br. J. Nurs. 8(19), 1305–1312 (1999).
[Crossref] [PubMed]

1998 (1)

D. Porock, L. Kristjanson, S. Nikoletti, F. Cameron, and P. Pedler, “Predicting the severity of radiation skin reactions in women with breast cancer,” Oncol. Nurs. Forum 25(6), 1019–1029 (1998).
[PubMed]

1995 (2)

N. Kollias, R. Gillies, J. A. Muccini, R. K. Uyeyama, S. B. Phillips, and L. A. Drake, “A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation,” J. Invest. Dermatol. 104(3), 421–424 (1995).
[Crossref] [PubMed]

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Ahmed, M.

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

Antonadou, D.

D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
[Crossref] [PubMed]

Arridge, S. R.

Baker, S. P.

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Barnes, E.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Barnett, G. C.

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

Baudelin, C.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Bell, N.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

Bellemann, M. E.

S. Smesny, S. Riemann, S. Riehemann, M. E. Bellemann, and H. Sauer, “Quantitative measurement of induced skin reddening using optical reflection spectroscopy--methodology and clinical application,” Biomed. Tech. (Berl.) 46(10), 280–286 (2001).
[Crossref] [PubMed]

Benderitter, M.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Bennett, N. C.

P. M. Herst, N. C. Bennett, A. E. Sutherland, R. I. Peszynski, D. B. Paterson, and M. L. Jasperse, “Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients,” Radiother. Oncol. 110(1), 137–143 (2014).
[Crossref] [PubMed]

Breen, D.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Buard, V.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Burnet, N. G.

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

Butler, J. A.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Cameron, F.

D. Porock, L. Kristjanson, S. Nikoletti, F. Cameron, and P. Pedler, “Predicting the severity of radiation skin reactions in women with breast cancer,” Oncol. Nurs. Forum 25(6), 1019–1029 (1998).
[PubMed]

Cerussi, A.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Chan, R. J.

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

Chen, W. P.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Chin, L.

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

Chin, L. C.

D. Yohan, A. Kim, E. Korpela, S. Liu, C. Niu, B. C. Wilson, and L. C. Chin, “Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy,” Biomed. Opt. Express 5(5), 1309–1320 (2014).
[Crossref] [PubMed]

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Chin, M. S.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Choe, R.

Chung, B.

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

Coles, C. E.

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

Corlu, A.

Czarnota, G.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Dadani, F.

De Angelis, C.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Dear, K. B.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Degraff, W. G.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Denham, J. W.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Douglas, B. G.

B. G. Douglas and J. F. Fowler, “The effect of multiple small doses of X rays on skin reactions in the mouse and a basic interpretation. 1976,” Radiat. Res. 178(2), AV125–AV138 (2012).
[Crossref] [PubMed]

Drake, L. A.

N. Kollias, R. Gillies, J. A. Muccini, R. K. Uyeyama, S. B. Phillips, and L. A. Drake, “A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation,” J. Invest. Dermatol. 104(3), 421–424 (1995).
[Crossref] [PubMed]

Dumont, D. J.

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Dunning, A. M.

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

Durduran, T.

Durkin, A.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Elliott, R. M.

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

Fitzgerald, T. J.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Fowler, J. F.

B. G. Douglas and J. F. Fowler, “The effect of multiple small doses of X rays on skin reactions in the mouse and a basic interpretation. 1976,” Radiat. Res. 178(2), AV125–AV138 (2012).
[Crossref] [PubMed]

Freniere, B. B.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Garantziotis, S.

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

Gaugler, M. H.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Gillies, R.

N. Kollias, R. Gillies, J. A. Muccini, R. K. Uyeyama, S. B. Phillips, and L. A. Drake, “A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation,” J. Invest. Dermatol. 104(3), 421–424 (1995).
[Crossref] [PubMed]

Giotis, A.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Guipaud, O.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Hamilton, C. S.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Heckler, C. E.

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

Herst, P. M.

P. M. Herst, N. C. Bennett, A. E. Sutherland, R. I. Peszynski, D. B. Paterson, and M. L. Jasperse, “Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients,” Radiother. Oncol. 110(1), 137–143 (2014).
[Crossref] [PubMed]

Hillman, E. M.

Holler, V.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Hsiang, D.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Huang, X.

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Ignotz, R. A.

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Isenberg, J. S.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Jang, W. H.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Jang, W. S.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Jasperse, M. L.

P. M. Herst, N. C. Bennett, A. E. Sutherland, R. I. Peszynski, D. B. Paterson, and M. L. Jasperse, “Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients,” Radiother. Oncol. 110(1), 137–143 (2014).
[Crossref] [PubMed]

Joseph, D. J.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Katz, A.

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

Khurana, M.

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Kim, A.

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

D. Yohan, A. Kim, E. Korpela, S. Liu, C. Niu, B. C. Wilson, and L. C. Chin, “Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy,” Biomed. Opt. Express 5(5), 1309–1320 (2014).
[Crossref] [PubMed]

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

A. Kim, M. Roy, F. Dadani, and B. C. Wilson, “A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients,” Opt. Express 18(6), 5580–5594 (2010).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Kim, K. H.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Kollias, N.

G. N. Stamatas and N. Kollias, “In vivo documentation of cutaneous inflammation using spectral imaging,” J. Biomed. Opt. 12(5), 051603 (2007).
[Crossref] [PubMed]

N. Kollias, R. Gillies, J. A. Muccini, R. K. Uyeyama, S. B. Phillips, and L. A. Drake, “A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation,” J. Invest. Dermatol. 104(3), 421–424 (1995).
[Crossref] [PubMed]

Korpela, E.

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

D. Yohan, A. Kim, E. Korpela, S. Liu, C. Niu, B. C. Wilson, and L. C. Chin, “Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy,” Biomed. Opt. Express 5(5), 1309–1320 (2014).
[Crossref] [PubMed]

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Kristjanson, L.

D. Porock, L. Kristjanson, S. Nikoletti, F. Cameron, and P. Pedler, “Predicting the severity of radiation skin reactions in women with breast cancer,” Oncol. Nurs. Forum 25(6), 1019–1029 (1998).
[PubMed]

Kron, T.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Lalikos, J. F.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Lancerotto, L.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

Ling, M.

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

Liu, S.

Liu, S. K.

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Lo, Y. C.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Lujan-Hernandez, J.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

MacBride, S.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

MacDougall, H.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

MacKinnon, K.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

Macmillan, M.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

Marquart, L.

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

Maxhimer, J. B.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

McLaren, C.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Mehta, R.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Milliat, F.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Mitera, G.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Moriyama, Y.

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

Morrow, G. R.

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

Muccini, J. A.

N. Kollias, R. Gillies, J. A. Muccini, R. K. Uyeyama, S. B. Phillips, and L. A. Drake, “A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation,” J. Invest. Dermatol. 104(3), 421–424 (1995).
[Crossref] [PubMed]

Munro, A.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

Myung, J. K.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Nikoletti, S.

D. Porock, L. Kristjanson, S. Nikoletti, F. Cameron, and P. Pedler, “Predicting the severity of radiation skin reactions in women with breast cancer,” Oncol. Nurs. Forum 25(6), 1019–1029 (1998).
[PubMed]

Niu, C.

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

D. Yohan, A. Kim, E. Korpela, S. Liu, C. Niu, B. C. Wilson, and L. C. Chin, “Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy,” Biomed. Opt. Express 5(5), 1309–1320 (2014).
[Crossref] [PubMed]

Noble-Adams, R.

R. Noble-Adams, “Radiation-induced skin reactions. 3: Evaluating the RISRAS,” Br. J. Nurs. 8(19), 1305–1312 (1999).
[Crossref] [PubMed]

Nordal, R.

M. Woo and R. Nordal, “Commissioning and evaluation of a new commercial small rodent x-ray irradiator,” Biomed Imaging Interv J 2(1), e10 (2006).
[Crossref] [PubMed]

O’Brien, M.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Orgill, D. P.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

Ostwald, P. M.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Pang, J.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Park, S.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Paterson, D. B.

P. M. Herst, N. C. Bennett, A. E. Sutherland, R. I. Peszynski, D. B. Paterson, and M. L. Jasperse, “Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients,” Radiother. Oncol. 110(1), 137–143 (2014).
[Crossref] [PubMed]

Pedler, P.

D. Porock, L. Kristjanson, S. Nikoletti, F. Cameron, and P. Pedler, “Predicting the severity of radiation skin reactions in women with breast cancer,” Oncol. Nurs. Forum 25(6), 1019–1029 (1998).
[PubMed]

Pentland, A. P.

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

Pepelassi, M.

D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
[Crossref] [PubMed]

Perez, M. R.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Peszynski, R. I.

P. M. Herst, N. C. Bennett, A. E. Sutherland, R. I. Peszynski, D. B. Paterson, and M. L. Jasperse, “Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients,” Radiother. Oncol. 110(1), 137–143 (2014).
[Crossref] [PubMed]

Pharoah, P. D.

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

Phillips, S. B.

N. Kollias, R. Gillies, J. A. Muccini, R. K. Uyeyama, S. B. Phillips, and L. A. Drake, “A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation,” J. Invest. Dermatol. 104(3), 421–424 (1995).
[Crossref] [PubMed]

Porock, D.

D. Porock, L. Kristjanson, S. Nikoletti, F. Cameron, and P. Pedler, “Predicting the severity of radiation skin reactions in women with breast cancer,” Oncol. Nurs. Forum 25(6), 1019–1029 (1998).
[PubMed]

Puglisi, M.

D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
[Crossref] [PubMed]

Raab, G.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

Ridnour, L. A.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Riehemann, S.

S. Smesny, S. Riemann, S. Riehemann, M. E. Bellemann, and H. Sauer, “Quantitative measurement of induced skin reddening using optical reflection spectroscopy--methodology and clinical application,” Biomed. Tech. (Berl.) 46(10), 280–286 (2001).
[Crossref] [PubMed]

Riemann, S.

S. Smesny, S. Riemann, S. Riehemann, M. E. Bellemann, and H. Sauer, “Quantitative measurement of induced skin reddening using optical reflection spectroscopy--methodology and clinical application,” Biomed. Tech. (Berl.) 46(10), 280–286 (2001).
[Crossref] [PubMed]

Roberts, D. D.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Roblyer, D.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Roy, M.

Ryan, J. L.

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

J. L. Ryan, “Ionizing radiation: the good, the bad, and the ugly,” J. Invest. Dermatol. 132(3), 985–993 (2012).
[Crossref] [PubMed]

Sache, A.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Sade, S.

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Saleeby, J. H.

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Salvo, N.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Samuel, L.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

Sauer, H.

S. Smesny, S. Riemann, S. Riehemann, M. E. Bellemann, and H. Sauer, “Quantitative measurement of induced skin reddening using optical reflection spectroscopy--methodology and clinical application,” Biomed. Tech. (Berl.) 46(10), 280–286 (2001).
[Crossref] [PubMed]

Schweiger, M.

Shih, H. B.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Shim, S.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Simpson, S. A.

J. W. Denham, C. S. Hamilton, S. A. Simpson, P. M. Ostwald, M. O’Brien, T. Kron, D. J. Joseph, and K. B. Dear, “Factors influencing the degree of erythematous skin reactions in humans,” Radiother. Oncol. 36(2), 107–120 (1995).
[Crossref] [PubMed]

Smesny, S.

S. Smesny, S. Riemann, S. Riehemann, M. E. Bellemann, and H. Sauer, “Quantitative measurement of induced skin reddening using optical reflection spectroscopy--methodology and clinical application,” Biomed. Tech. (Berl.) 46(10), 280–286 (2001).
[Crossref] [PubMed]

Soto-Pantoja, D. R.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Squiban, C.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Stacey, E.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Stamatas, G. N.

G. N. Stamatas and N. Kollias, “In vivo documentation of cutaneous inflammation using spectral imaging,” J. Biomed. Opt. 12(5), 051603 (2007).
[Crossref] [PubMed]

Strom, H. M.

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

Sutherland, A. E.

P. M. Herst, N. C. Bennett, A. E. Sutherland, R. I. Peszynski, D. B. Paterson, and M. L. Jasperse, “Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients,” Radiother. Oncol. 110(1), 137–143 (2014).
[Crossref] [PubMed]

Synodinou, M.

D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
[Crossref] [PubMed]

Tamarat, R.

V. Holler, V. Buard, M. H. Gaugler, O. Guipaud, C. Baudelin, A. Sache, M. R. Perez, C. Squiban, R. Tamarat, F. Milliat, and M. Benderitter, “Pravastatin limits radiation-induced vascular dysfunction in the skin,” J. Invest. Dermatol. 129(5), 1280–1291 (2009).
[Crossref] [PubMed]

Tanamai, W.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Throuvalas, N.

D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
[Crossref] [PubMed]

Tromberg, B.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Tsokos, M.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Ueda, S.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Uyeyama, R. K.

N. Kollias, R. Gillies, J. A. Muccini, R. K. Uyeyama, S. B. Phillips, and L. A. Drake, “A single parameter, oxygenated hemoglobin, can be used to quantify experimental irritant-induced inflammation,” J. Invest. Dermatol. 104(3), 421–424 (1995).
[Crossref] [PubMed]

van Draanen, J.

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Van Slyke, P.

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Wang, T.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Webster, J.

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

Wells, M.

M. Wells, M. Macmillan, G. Raab, S. MacBride, N. Bell, K. MacKinnon, H. MacDougall, L. Samuel, and A. Munro, “Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial,” Radiother. Oncol. 73(2), 153–162 (2004).
[Crossref] [PubMed]

West, C. M.

G. C. Barnett, C. M. West, A. M. Dunning, R. M. Elliott, C. E. Coles, P. D. Pharoah, and N. G. Burnet, “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nat. Rev. Cancer 9(2), 134–142 (2009).
[Crossref] [PubMed]

Williams, J. P.

J. L. Ryan, C. E. Heckler, M. Ling, A. Katz, J. P. Williams, A. P. Pentland, and G. R. Morrow, “Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients,” Radiat. Res. 180(1), 34–43 (2013).
[Crossref] [PubMed]

Wilson, B. C.

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

D. Yohan, A. Kim, E. Korpela, S. Liu, C. Niu, B. C. Wilson, and L. C. Chin, “Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy,” Biomed. Opt. Express 5(5), 1309–1320 (2014).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

A. Kim, M. Roy, F. Dadani, and B. C. Wilson, “A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients,” Opt. Express 18(6), 5580–5594 (2010).
[Crossref] [PubMed]

Wink, D. A.

J. B. Maxhimer, D. R. Soto-Pantoja, L. A. Ridnour, H. B. Shih, W. G. Degraff, M. Tsokos, D. A. Wink, J. S. Isenberg, and D. D. Roberts, “Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling,” Sci. Transl. Med. 1(3), 3ra7 (2009).
[Crossref] [PubMed]

Woo, M.

M. Woo and R. Nordal, “Commissioning and evaluation of a new commercial small rodent x-ray irradiator,” Biomed Imaging Interv J 2(1), e10 (2006).
[Crossref] [PubMed]

Yodh, A. G.

Yohan, D.

L. Chin, E. Korpela, A. Kim, D. Yohan, C. Niu, B. C. Wilson, and S. K. Liu, “Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model,” J. Vis. Exp. 111, 53573 (2016).
[PubMed]

D. Yohan, A. Kim, E. Korpela, S. Liu, C. Niu, B. C. Wilson, and L. C. Chin, “Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy,” Biomed. Opt. Express 5(5), 1309–1320 (2014).
[Crossref] [PubMed]

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

Yoon, Y.

W. H. Jang, S. Shim, T. Wang, Y. Yoon, W. S. Jang, J. K. Myung, S. Park, and K. H. Kim, “In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy,” Sci. Rep. 6, 19216 (2016).
[Crossref] [PubMed]

Biomed Imaging Interv J (1)

M. Woo and R. Nordal, “Commissioning and evaluation of a new commercial small rodent x-ray irradiator,” Biomed Imaging Interv J 2(1), e10 (2006).
[Crossref] [PubMed]

Biomed. Opt. Express (1)

Biomed. Tech. (Berl.) (1)

S. Smesny, S. Riemann, S. Riehemann, M. E. Bellemann, and H. Sauer, “Quantitative measurement of induced skin reddening using optical reflection spectroscopy--methodology and clinical application,” Biomed. Tech. (Berl.) 46(10), 280–286 (2001).
[Crossref] [PubMed]

BMC Cancer (2)

E. Korpela, D. Yohan, L. C. Chin, A. Kim, X. Huang, S. Sade, P. Van Slyke, D. J. Dumont, and S. K. Liu, “Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model,” BMC Cancer 14(1), 614 (2014).
[Crossref] [PubMed]

R. J. Chan, J. Webster, B. Chung, L. Marquart, M. Ahmed, and S. Garantziotis, “Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials,” BMC Cancer 14(1), 53 (2014).
[Crossref] [PubMed]

Br. J. Nurs. (1)

R. Noble-Adams, “Radiation-induced skin reactions. 3: Evaluating the RISRAS,” Br. J. Nurs. 8(19), 1305–1312 (1999).
[Crossref] [PubMed]

Curr. Oncol. (1)

N. Salvo, E. Barnes, J. van Draanen, E. Stacey, G. Mitera, D. Breen, A. Giotis, G. Czarnota, J. Pang, and C. De Angelis, “Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature,” Curr. Oncol. 17(4), 94–112 (2010).
[PubMed]

Front. Oncol. (1)

M. S. Chin, B. B. Freniere, L. Lancerotto, J. Lujan-Hernandez, J. H. Saleeby, Y. C. Lo, D. P. Orgill, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral Imaging as an Early Biomarker for Radiation Exposure and Microcirculatory Damage,” Front. Oncol. 5, 232 (2015).
[Crossref] [PubMed]

Int. J. Radiat. Oncol. Biol. Phys. (1)

D. Antonadou, M. Pepelassi, M. Synodinou, M. Puglisi, and N. Throuvalas, “Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer,” Int. J. Radiat. Oncol. Biol. Phys. 52(3), 739–747 (2002).
[Crossref] [PubMed]

J. Biomed. Opt. (3)

M. S. Chin, B. B. Freniere, Y. C. Lo, J. H. Saleeby, S. P. Baker, H. M. Strom, R. A. Ignotz, J. F. Lalikos, and T. J. Fitzgerald, “Hyperspectral imaging for early detection of oxygenation and perfusion changes in irradiated skin,” J. Biomed. Opt. 17(2), 026010 (2012).
[Crossref] [PubMed]

G. N. Stamatas and N. Kollias, “In vivo documentation of cutaneous inflammation using spectral imaging,” J. Biomed. Opt. 12(5), 051603 (2007).
[Crossref] [PubMed]

A. Kim, M. Khurana, Y. Moriyama, and B. C. Wilson, “Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements,” J. Biomed. Opt. 15(6), 067006 (2010).
[Crossref] [PubMed]

J. Invest. Dermatol. (3)

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Figures (4)

Fig. 1
Fig. 1 DOS imaging equipment (left) and diagram of the probe source-detector configuration (right).
Fig. 2
Fig. 2 Mean Hb, StO2, and b ( ± SD) normalized to baseline over 4 days post irradiation. (Left) Values rise sharply in the irradiated group treated with PBS (compared to the non-irradiated group). Hb levels of the irradiated group treated with VT remain comparable to the non-irradiated group. (Middle) StO2 increases in both irradiated groups vs. the non-irradiated group. (Right) No statistical significance is reached in differences between groups for b.
Fig. 3
Fig. 3 Disparate day 14 peak damage radiation toxicity wounds for the PBS-treated and VT-treated, irradiated skin. (Left) Photographs of wounds, scale bars = 1 cm. (Right) Day 14 mean wound sizes ± SD (as a fraction of the total irradiated surface area) between the two irradiated groups. The VT group has smaller wounds, p = 0.027.
Fig. 4
Fig. 4 Median radiation skin toxicity scores ± IQR between the two irradiated groups. No differences reached statistical significance.

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