Abstract

We investigated the heart structural remodeling in the mdx4cv mouse model of Duchenne cardiomyopathy using optical polarization tractography. Whole heart tractography was obtained in freshly dissected hearts from six mdx4cv mice. Six hearts from C57BL/6J mice were also imaged as the normal control. The mdx4cv hearts were significantly larger than the control hearts and had significantly higher between–subject variations in myofiber organization. While both strains showed classic cross-helical fiber organization in the left ventricle, the rate of the myocardial fiber orientation change across the heart wall was significantly altered in the right ventricle of the mdx4cv heart.

© 2017 Optical Society of America

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  1. D. Duan, “Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy,” Hum. Mol. Genet. 15(2), R253–R261 (2006).
    [Crossref] [PubMed]
  2. Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
    [Crossref] [PubMed]
  3. D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
    [Crossref] [PubMed]
  4. P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
    [Crossref] [PubMed]
  5. D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
    [Crossref] [PubMed]
  6. C. Mekkaoui, T. G. Reese, M. P. Jackowski, H. Bhat, and D. E. Sosnovik, “Diffusion MRI in the heart,” NMR Biomed. (2015), doi:.
    [Crossref]
  7. F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
    [Crossref] [PubMed]
  8. Y. Wang and G. Yao, “Optical tractography of the mouse heart using polarization-sensitive optical coherence tomography,” Biomed. Opt. Express 4(11), 2540–2545 (2013).
    [Crossref] [PubMed]
  9. Y. Wang, K. Zhang, N. B. Wasala, D. Duan, and G. Yao, “Optical polarization tractography revealed significant fiber disarray in skeletal muscles of a mouse model for Duchenne muscular dystrophy,” Biomed. Opt. Express 6(2), 347–352 (2015).
    [Crossref] [PubMed]
  10. L. Azinfar, M. Ravanfar, Y. Wang, K. Zhang, D. Duan, and G. Yao, “High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography,” J. Biophoton. (2015), doi:.
    [Crossref]
  11. Y. Wang, K. Zhang, N. B. Wasala, X. Yao, D. Duan, and G. Yao, “Histology validation of mapping depth-resolved cardiac fiber orientation in fresh mouse heart using optical polarization tractography,” Biomed. Opt. Express 5(8), 2843–2855 (2014).
    [Crossref] [PubMed]
  12. C. Fan and G. Yao, “Full-range spectral domain Jones matrix optical coherence tomography using a single spectral camera,” Opt. Express 20(20), 22360–22371 (2012).
    [Crossref] [PubMed]
  13. C. Fan and G. Yao, “Imaging myocardial fiber orientation using polarization sensitive optical coherence tomography,” Biomed. Opt. Express 4(3), 460–465 (2013).
    [Crossref] [PubMed]
  14. Y. Wang, M. Ravanfar, K. Zhang, D. Duan, and G. Yao, “Mapping 3D fiber orientation in tissue using dual-angle optical polarization tractography,” Biomed. Opt. Express 7(10), 3855–3870 (2016).
    [Crossref] [PubMed]
  15. B. Ciszek, D. Skubiszewska, and A. Ratajska, “The anatomy of the cardiac veins in mice,” J. Anat. 211(1), 53–63 (2007).
    [Crossref] [PubMed]
  16. P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
    [Crossref] [PubMed]
  17. T. A. Meyers and D. Townsend, “Early Right Ventricular Fibrosis and Reduction in Biventricular Cardiac Reserve in the Dystrophin-Deficient mdx Heart,” Am. J. Physiol. Heart Circ. Physiol. 308(4), H303–H315 (2015).
    [Crossref] [PubMed]
  18. I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
    [Crossref] [PubMed]
  19. D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
    [Crossref] [PubMed]

2016 (3)

Y. Wang, M. Ravanfar, K. Zhang, D. Duan, and G. Yao, “Mapping 3D fiber orientation in tissue using dual-angle optical polarization tractography,” Biomed. Opt. Express 7(10), 3855–3870 (2016).
[Crossref] [PubMed]

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

2015 (2)

T. A. Meyers and D. Townsend, “Early Right Ventricular Fibrosis and Reduction in Biventricular Cardiac Reserve in the Dystrophin-Deficient mdx Heart,” Am. J. Physiol. Heart Circ. Physiol. 308(4), H303–H315 (2015).
[Crossref] [PubMed]

Y. Wang, K. Zhang, N. B. Wasala, D. Duan, and G. Yao, “Optical polarization tractography revealed significant fiber disarray in skeletal muscles of a mouse model for Duchenne muscular dystrophy,” Biomed. Opt. Express 6(2), 347–352 (2015).
[Crossref] [PubMed]

2014 (1)

2013 (2)

2012 (4)

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

C. Fan and G. Yao, “Full-range spectral domain Jones matrix optical coherence tomography using a single spectral camera,” Opt. Express 20(20), 22360–22371 (2012).
[Crossref] [PubMed]

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

2007 (1)

B. Ciszek, D. Skubiszewska, and A. Ratajska, “The anatomy of the cardiac veins in mice,” J. Anat. 211(1), 53–63 (2007).
[Crossref] [PubMed]

2006 (1)

D. Duan, “Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy,” Hum. Mol. Genet. 15(2), R253–R261 (2006).
[Crossref] [PubMed]

2005 (2)

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
[Crossref] [PubMed]

1969 (1)

D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
[Crossref] [PubMed]

Agger, P.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Anderson, R. H.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Azinfar, L.

L. Azinfar, M. Ravanfar, Y. Wang, K. Zhang, D. Duan, and G. Yao, “High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography,” J. Biophoton. (2015), doi:.
[Crossref]

Barbin, I. C. C.

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

Beg, M. F.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Benoist, D.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Benson, A. P.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Bernus, O.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Bersan Rovere, M.

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

Bhat, H.

C. Mekkaoui, T. G. Reese, M. P. Jackowski, H. Bhat, and D. E. Sosnovik, “Diffusion MRI in the heart,” NMR Biomed. (2015), doi:.
[Crossref]

Camelliti, P.

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

Carr, C. A.

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

Caruthers, S. D.

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

Cassan, C.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Cazorla, O.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Chen, J.

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

Cheng, Y. J.

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

Ciszek, B.

B. Ciszek, D. Skubiszewska, and A. Ratajska, “The anatomy of the cardiac veins in mice,” J. Anat. 211(1), 53–63 (2007).
[Crossref] [PubMed]

Clarke, K.

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

Davies, K. E.

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

de Oliveira Moreira, D.

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

Drinkhill, M. J.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Duan, D.

Efimov, I. R.

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

Ennis, D. B.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Fan, C.

Faris, O. P.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Frandsen, J. R.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Gilbert, S. H.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Gugino, S.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Helm, P. A.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Hjortdal, V.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Hyatt, C. J.

F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
[Crossref] [PubMed]

Jackowski, M. P.

C. Mekkaoui, T. G. Reese, M. P. Jackowski, H. Bhat, and D. E. Sosnovik, “Diffusion MRI in the heart,” NMR Biomed. (2015), doi:.
[Crossref]

Kass, D.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Lakshminrusimha, S.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Lang, D.

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

Laustsen, C.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Leclercq, C.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Marques, M. J.

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

McVeigh, E.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Mekkaoui, C.

C. Mekkaoui, T. G. Reese, M. P. Jackowski, H. Bhat, and D. E. Sosnovik, “Diffusion MRI in the heart,” NMR Biomed. (2015), doi:.
[Crossref]

Meyers, T. A.

T. A. Meyers and D. Townsend, “Early Right Ventricular Fibrosis and Reduction in Biventricular Cardiac Reserve in the Dystrophin-Deficient mdx Heart,” Am. J. Physiol. Heart Circ. Physiol. 308(4), H303–H315 (2015).
[Crossref] [PubMed]

Miller, M. I.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Mironov, S.

F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
[Crossref] [PubMed]

Patel, D. P.

D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
[Crossref] [PubMed]

Pereira, J. A.

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

Pertsov, A. M.

F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
[Crossref] [PubMed]

Ratajska, A.

B. Ciszek, D. Skubiszewska, and A. Ratajska, “The anatomy of the cardiac veins in mice,” J. Anat. 211(1), 53–63 (2007).
[Crossref] [PubMed]

Ravanfar, M.

Y. Wang, M. Ravanfar, K. Zhang, D. Duan, and G. Yao, “Mapping 3D fiber orientation in tissue using dual-angle optical polarization tractography,” Biomed. Opt. Express 7(10), 3855–3870 (2016).
[Crossref] [PubMed]

L. Azinfar, M. Ravanfar, Y. Wang, K. Zhang, D. Duan, and G. Yao, “High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography,” J. Biophoton. (2015), doi:.
[Crossref]

Reese, T. G.

C. Mekkaoui, T. G. Reese, M. P. Jackowski, H. Bhat, and D. E. Sosnovik, “Diffusion MRI in the heart,” NMR Biomed. (2015), doi:.
[Crossref]

Ross, J.

D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
[Crossref] [PubMed]

Saint, D. A.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Santo Neto, H.

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

Simons, S. B.

F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
[Crossref] [PubMed]

Skubiszewska, D.

B. Ciszek, D. Skubiszewska, and A. Ratajska, “The anatomy of the cardiac veins in mice,” J. Anat. 211(1), 53–63 (2007).
[Crossref] [PubMed]

Smerup, M.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Sonnenblick, E. H.

D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
[Crossref] [PubMed]

Sosnovik, D. E.

C. Mekkaoui, T. G. Reese, M. P. Jackowski, H. Bhat, and D. E. Sosnovik, “Diffusion MRI in the heart,” NMR Biomed. (2015), doi:.
[Crossref]

Spotnitz, H. M.

D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
[Crossref] [PubMed]

Steele, D. S.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Steinhorn, R. H.

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

Stones, R.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Streeter, D. D.

D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
[Crossref] [PubMed]

Stuckey, D. J.

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

Townsend, D.

T. A. Meyers and D. Townsend, “Early Right Ventricular Fibrosis and Reduction in Biventricular Cardiac Reserve in the Dystrophin-Deficient mdx Heart,” Am. J. Physiol. Heart Circ. Physiol. 308(4), H303–H315 (2015).
[Crossref] [PubMed]

Tyler, D. J.

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

Vetter, F. J.

F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
[Crossref] [PubMed]

Wang, Y.

Wasala, N. B.

White, E.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Wickline, S. A.

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

Winslow, R. L.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Yang, Z.

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

Yao, G.

Y. Wang, M. Ravanfar, K. Zhang, D. Duan, and G. Yao, “Mapping 3D fiber orientation in tissue using dual-angle optical polarization tractography,” Biomed. Opt. Express 7(10), 3855–3870 (2016).
[Crossref] [PubMed]

Y. Wang, K. Zhang, N. B. Wasala, D. Duan, and G. Yao, “Optical polarization tractography revealed significant fiber disarray in skeletal muscles of a mouse model for Duchenne muscular dystrophy,” Biomed. Opt. Express 6(2), 347–352 (2015).
[Crossref] [PubMed]

Y. Wang, K. Zhang, N. B. Wasala, X. Yao, D. Duan, and G. Yao, “Histology validation of mapping depth-resolved cardiac fiber orientation in fresh mouse heart using optical polarization tractography,” Biomed. Opt. Express 5(8), 2843–2855 (2014).
[Crossref] [PubMed]

Y. Wang and G. Yao, “Optical tractography of the mouse heart using polarization-sensitive optical coherence tomography,” Biomed. Opt. Express 4(11), 2540–2545 (2013).
[Crossref] [PubMed]

C. Fan and G. Yao, “Imaging myocardial fiber orientation using polarization sensitive optical coherence tomography,” Biomed. Opt. Express 4(3), 460–465 (2013).
[Crossref] [PubMed]

C. Fan and G. Yao, “Full-range spectral domain Jones matrix optical coherence tomography using a single spectral camera,” Opt. Express 20(20), 22360–22371 (2012).
[Crossref] [PubMed]

L. Azinfar, M. Ravanfar, Y. Wang, K. Zhang, D. Duan, and G. Yao, “High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography,” J. Biophoton. (2015), doi:.
[Crossref]

Yao, X.

Younes, L.

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Zhang, K.

Am. J. Physiol. Heart Circ. Physiol. (3)

Y. J. Cheng, D. Lang, S. D. Caruthers, I. R. Efimov, J. Chen, and S. A. Wickline, “Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts,” Am. J. Physiol. Heart Circ. Physiol. 303(5), H559–H568 (2012).
[Crossref] [PubMed]

D. Benoist, R. Stones, M. J. Drinkhill, A. P. Benson, Z. Yang, C. Cassan, S. H. Gilbert, D. A. Saint, O. Cazorla, D. S. Steele, O. Bernus, and E. White, “Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension,” Am. J. Physiol. Heart Circ. Physiol. 302(11), H2381–H2395 (2012).
[Crossref] [PubMed]

T. A. Meyers and D. Townsend, “Early Right Ventricular Fibrosis and Reduction in Biventricular Cardiac Reserve in the Dystrophin-Deficient mdx Heart,” Am. J. Physiol. Heart Circ. Physiol. 308(4), H303–H315 (2015).
[Crossref] [PubMed]

Biomed. Opt. Express (5)

Circ. Res. (3)

F. J. Vetter, S. B. Simons, S. Mironov, C. J. Hyatt, and A. M. Pertsov, “Epicardial fiber organization in swine right ventricle and its impact on propagation,” Circ. Res. 96(2), 244–251 (2005).
[Crossref] [PubMed]

D. D. Streeter, H. M. Spotnitz, D. P. Patel, J. Ross, and E. H. Sonnenblick, “Fiber orientation in the canine left ventricle during diastole and systole,” Circ. Res. 24(3), 339–347 (1969).
[Crossref] [PubMed]

P. A. Helm, L. Younes, M. F. Beg, D. B. Ennis, C. Leclercq, O. P. Faris, E. McVeigh, D. Kass, M. I. Miller, and R. L. Winslow, “Evidence of structural remodeling in the dyssynchronous failing heart,” Circ. Res. 98(1), 125–132 (2005).
[Crossref] [PubMed]

Hum. Mol. Genet. (1)

D. Duan, “Challenges and opportunities in dystrophin-deficient cardiomyopathy gene therapy,” Hum. Mol. Genet. 15(2), R253–R261 (2006).
[Crossref] [PubMed]

J. Anat. (2)

B. Ciszek, D. Skubiszewska, and A. Ratajska, “The anatomy of the cardiac veins in mice,” J. Anat. 211(1), 53–63 (2007).
[Crossref] [PubMed]

I. C. C. Barbin, J. A. Pereira, M. Bersan Rovere, D. de Oliveira Moreira, M. J. Marques, and H. Santo Neto, “Diaphragm degeneration and cardiac structure in mdx mouse: potential clinical implications for Duchenne muscular dystrophy,” J. Anat. 228(5), 784–791 (2016).
[Crossref] [PubMed]

Opt. Express (1)

Pediatr. Res. (1)

P. Agger, S. Lakshminrusimha, C. Laustsen, S. Gugino, J. R. Frandsen, M. Smerup, R. H. Anderson, V. Hjortdal, and R. H. Steinhorn, “The myocardial architecture changes in persistent pulmonary hypertension of the newborn in an ovine animal model,” Pediatr. Res. 79(4), 565–574 (2016).
[Crossref] [PubMed]

PLoS One (1)

D. J. Stuckey, C. A. Carr, P. Camelliti, D. J. Tyler, K. E. Davies, and K. Clarke, “In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy,” PLoS One 7(1), e28569 (2012).
[Crossref] [PubMed]

Other (2)

L. Azinfar, M. Ravanfar, Y. Wang, K. Zhang, D. Duan, and G. Yao, “High resolution imaging of the fibrous microstructure in bovine common carotid artery using optical polarization tractography,” J. Biophoton. (2015), doi:.
[Crossref]

C. Mekkaoui, T. G. Reese, M. P. Jackowski, H. Bhat, and D. E. Sosnovik, “Diffusion MRI in the heart,” NMR Biomed. (2015), doi:.
[Crossref]

Supplementary Material (8)

NameDescription
» Visualization 1: AVI (5345 KB)      3D intensity view of a BL6 heart
» Visualization 2: AVI (6210 KB)      3D intensity view of an mdx heart
» Visualization 3: AVI (6775 KB)      3D tractography of a BL6 heart
» Visualization 4: AVI (8548 KB)      3D tractography of an mdx heart
» Visualization 5: AVI (6719 KB)      Fiber orientation change across the left ventricle of a BL6 heart
» Visualization 6: AVI (10324 KB)      Fiber orientation change across the left ventricle of an mdx heart
» Visualization 7: AVI (8845 KB)      Fiber orientation change across the right ventricle of a BL6 heart
» Visualization 8: AVI (9707 KB)      Fiber orientation change across the right ventricle of an mdx heart

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Figures (4)

Fig. 1
Fig. 1 (a) Intensity images of a BL6 heart (Visualization 1) and an mdx heart (Visualization 2). (b) The corresponding 3D tractography of the BL6 heart (Visualization 3) and the mdx heart (Visualization 4), both with the left ventricle (LV) facing front. Also shown are depth-resolved tractography showing myofibers passing through a 1.5 mm high region of interest (green plate) across (c) the LV (Visualization 5 and Visualization 6) and (d) the right ventricle (RV) (Visualization 7 and Visualization 8) of the two hearts. of the BL10 and mdx hearts, respectively
Fig. 2
Fig. 2 (a) An illustration of the “window” in LV and RV (blue boxes) for quantitative analysis. LCV: left cardiac vein; RCV: right cardiac vein [15]. Also shown are example depth profiles of myocardial fiber orientation calculated at ROIs in the (b) LV and (c) RV as labeled in red boxes in (a). These sample data were obtained from the same hearts shown in Fig. 1.
Fig. 3
Fig. 3 (a) Examples of color-coded “slopes” of fiber orientation change with depth in the LV and RV of the same hearts shown in Fig. 2. (b) Distributions of the fiber orientation slopes obtained in all six BL6 hearts and six mdx hearts within the same LV and RV evaluation windows as defined in Fig. 2(a). BL6#1 and mdx#6 were the mice used in (a).
Fig. 4
Fig. 4 A group comparison of the average rate of fiber orientation change with depth in the LV and RV of the six BL6 mice and six mdx mice. * p<0.01.

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