Abstract

Red blood cells (RBCs) are known to be the most suitable cells to study oxidative stress, which is implicated in the etiopathology of many human diseases. The goal of the current study was to develop a new effective approach for assessing oxidative stress in human living RBCs using two-photon microscopy. To mimic oxidative stress in human living RBCs, an in vitro model was generated followed by two-photon microscopy imaging. The results revealed that oxidative stress is clearly visible on the two-photon microscopy images of RBCs under oxidative stress compared to no fluorescence in controls (P<0.0001). This novel approach for oxidative stress investigation in human living RBCs could efficiently be applied in clinical research and antioxidant compounds testing.

© 2017 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

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References

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2017 (2)

C. E. Pinzón-Díaz, J. V. Calderón-Salinas, M. M. Rosas-Flores, G. Hernández, A. López-Betancourt, and M. A. Quintanar-Escorza, “Eryptosis and oxidative damage in hypertensive and dyslipidemic patients,” Mol. Cell. Biochem. 434, 1–9 (2017).
[PubMed]

H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
[PubMed]

2016 (3)

L. M. Al-Naama, M. K. Hassan, and J. K. Mehdi, “Association of erythrocytes antioxidant enzymes and their cofactors with markers of oxidative stress in patients with sickle cell anemia,” Qatar Med. J. 2015(2), 14 (2016).
[PubMed]

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

2015 (2)

G. Tsakanova, E. Arakelova, A. Soghoyan, and V. Ayvazyan, “Oxidative stress and post-ischemic inflammatory response in ischemic stroke complicated with diabetes mellitus type 2,” J. Biosci. Med. 3, 94–98 (2015).

R. Datta, A. Alfonso-García, R. Cinco, and E. Gratton, “Fluorescence lifetime imaging of endogenous biomarker of oxidative stress,” Sci. Rep. 5, 9848 (2015).
[PubMed]

2014 (1)

S. I. Dikalov and D. G. Harrison, “Methods for detection of mitochondrial and cellular reactive oxygen species,” Antioxid. Redox Signal. 20(2), 372–382 (2014).
[PubMed]

2013 (5)

M. Saxena and S. Sarkar, “Fluorescence imaging of human erythrocytes by carbon nanoparticles isolated from food stuff and their fluorescence enhancement by blood plasma,” Mater. Express 3, 201–209 (2013).

Y. Miura, G. Huettmann, R. Orzekowsky-Schroeder, P. Steven, M. Szaszák, N. Koop, and R. Brinkmann, “Two-photon microscopy and fluorescence lifetime imaging of retinal pigment epithelial cells under oxidative stress,” Invest. Ophthalmol. Vis. Sci. 54(5), 3366–3377 (2013).
[PubMed]

C. de la Haba, J. R. Palacio, P. Martínez, and A. Morros, “Effect of oxidative stress on plasma membrane fluidity of THP-1 induced macrophages,” Biochim. Biophys. Acta 1828(2), 357–364 (2013).
[PubMed]

K. Masamoto, H. Kawaguchi, H. Ito, and I. Kanno, “Dynamic two-photon imaging of cerebral microcirculation using fluorescently labeled red blood cells and plasma,” Adv. Exp. Med. Biol. 765, 163–168 (2013).
[PubMed]

E. C. Jensen, “Quantitative analysis of histological staining and fluorescence using ImageJ,” Anat. Rec. (Hoboken) 296(3), 378–381 (2013).
[PubMed]

2012 (4)

F. Long, J. Zhou, and H. Peng, “Visualization and analysis of 3D microscopic images,” PLOS Comput. Biol. 8(6), e1002519 (2012).
[PubMed]

C. A. Schneider, W. S. Rasband, and K. W. Eliceiri, “NIH Image to ImageJ: 25 years of image analysis,” Nat. Methods 9(7), 671–675 (2012).
[PubMed]

A. I. Pogue, B. M. Jones, S. Bhattacharjee, M. E. Percy, Y. Zhao, and W. J. Lukiw, “Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a cell permeant tracer,” Int. J. Mol. Sci. 13(8), 9615–9626 (2012).
[PubMed]

H. Y. Ahn, K. E. Fairfull-Smith, B. J. Morrow, V. Lussini, B. Kim, M. V. Bondar, S. E. Bottle, and K. D. Belfield, “Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides,” J. Am. Chem. Soc. 134(10), 4721–4730 (2012).
[PubMed]

2011 (4)

C. Stringari, A. Cinquin, O. Cinquin, M. A. Digman, P. J. Donovan, and E. Gratton, “Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue,” Proc. Natl. Acad. Sci. U.S.A. 108(33), 13582–13587 (2011).
[PubMed]

D. Wu and P. Yotnda, “Production and detection of reactive oxygen species (ROS) in cancers,” J. Vis. Exp. 57(57), 3357 (2011).
[PubMed]

C. Cottet-Rousselle, X. Ronot, X. Leverve, and J.-F. Mayol, “Cytometric assessment of mitochondria using fluorescent probes,” Cytometry A 79(6), 405–425 (2011).
[PubMed]

G. V. Tsakanova, V. A. Ayvazyan, A. S. Boyajyan, E. A. Arakelova, G. S. Grigoryan, A. A. Guevorkyan, and A. A. Mamikonyan, “Comparative analysis of the antioxidant system capacity and intensity of lipid peroxidation process in ischemic stroke complicated and none-complicated with diabetes mellitus type 2 and in diabetes mellitus type 2,” Bull. Exp. Biol. Med. 151(5), 496–500 (2011).
[PubMed]

2010 (3)

K. B. Pandey, N. Mishra, and S. I. Rizvi, “Protein oxidation biomarkers in plasma of type 2 diabetic patients,” Clin. Biochem. 43(4-5), 508–511 (2010).
[PubMed]

K. B. Pandey, M. M. Mehdi, P. K. Maurya, and S. I. Rizvi, “Plasma protein oxidation and its correlation with antioxidant potential during human aging,” Dis. Markers 29(1), 31–36 (2010).
[PubMed]

E. Eruslanov and S. Kusmartsev, “Identification of ROS using oxidized DCFDA and flow-cytometry,” Methods Mol. Biol. 594, 57–72 (2010).
[PubMed]

2007 (4)

K. Rahman, “Studies on free radicals, antioxidants, and co-factors,” Clin. Interv. Aging 2(2), 219–236 (2007).
[PubMed]

A. Kinoshita, Y. Nakayama, T. Kitayama, and M. Tomita, “Simulation study of methemoglobin reduction in erythrocytes. Differential contributions of two pathways to tolerance to oxidative stress,” FEBS J. 274(6), 1449–1458 (2007).
[PubMed]

R. B. Sawant, S. K. Jathar, S. B. Rajadhyaksha, and P. T. Kadam, “Red cell hemolysis during processing and storage,” Asian J. Transfus. Sci. 1(2), 47–51 (2007).
[PubMed]

M. C. Skala, K. M. Riching, A. Gendron-Fitzpatrick, J. Eickhoff, K. W. Eliceiri, J. G. White, and N. Ramanujam, “In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia,” Proc. Natl. Acad. Sci. U.S.A. 104(49), 19494–19499 (2007).
[PubMed]

2006 (1)

F. Lang, K. S. Lang, P. A. Lang, S. M. Huber, and T. Wieder, “Mechanisms and significance of eryptosis,” Antioxid. Redox Signal. 8(7-8), 1183–1192 (2006).
[PubMed]

2005 (2)

F. Mao, Q. Xing, K. Wang, L. Lang, Zh. Wang, L. Chai, and Q. Wang, “Optical trapping of red blood cells and two-photon excitation-based photodynamic study using a femtosecond laser,” Opt. Commun. 256, 358–363 (2005).

H. Kaynar, M. Meral, H. Turhan, M. Keles, G. Celik, and F. Akcay, “Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer,” Cancer Lett. 227(2), 133–139 (2005).
[PubMed]

2004 (2)

Y. Aksoy, M. Balk, H. Ögüs, and N. Özer, “The mechanism of inhibition of human erythrocyte catalase by azide,” Turk. J. Biol. 28, 65–70 (2004).

A. Perl, P. Gergely, and K. Banki, “Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus,” Int. Rev. Immunol. 23(3-4), 293–313 (2004).
[PubMed]

2003 (2)

T. J. Guzik, R. Korbut, and T. Adamek-Guzik, “Nitric oxide and superoxide in inflammation and immune regulation,” J. Physiol. Pharmacol. 54(4), 469–487 (2003).
[PubMed]

M. E. McLellan, S. T. Kajdasz, B. T. Hyman, and B. J. Bacskai, “In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy,” J. Neurosci. 23(6), 2212–2217 (2003).
[PubMed]

2002 (1)

Y. Niihara, J. Ge, O. Shalev, H. Wu, A. Tu, and K. R. Tanaka, “Desferrioxamine decreases NAD redox potential of intact red blood cells: evidence for desferrioxamine as an inducer of oxidant stress in red blood cells,” BMC Clin. Pharmacol. 2, 8 (2002).
[PubMed]

2001 (1)

R. Nowakowski, P. Luckham, and P. Winlove, “Imaging erythrocytes under physiological conditions by atomic force microscopy,” Biochim. Biophys. Acta 1514(2), 170–176 (2001).
[PubMed]

2000 (1)

W. G. Siems, O. Sommerburg, and T. Grune, “Erythrocyte free radical and energy metabolism,” Clin. Nephrol. 53(1Suppl), S9–S17 (2000).
[PubMed]

1999 (2)

P. Prieto, M. Pineda, and M. Aguilar, “Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E,” Anal. Biochem. 269(2), 337–341 (1999).
[PubMed]

H. N. Kirkman, M. Rolfo, A. M. Ferraris, and G. F. Gaetani, “Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometry,” J. Biol. Chem. 274(20), 13908–13914 (1999).
[PubMed]

1998 (2)

C. T. Evelo, A. A. Spooren, R. A. Bisschops, L. G. Baars, and J. M. Neis, “Two mechanisms for toxic effects of hydroxylamines in human erythrocytes: involvement of free radicals and risk of potentiation,” Blood Cells Mol. Dis. 24(3), 280–295 (1998).
[PubMed]

S. Mendiratta, Z. C. Qu, and J. M. May, “Erythrocyte ascorbate recycling: antioxidant effects in blood,” Free Radic. Biol. Med. 24(5), 789–797 (1998).
[PubMed]

1995 (3)

W. Brandwilliams, M. E. Cuvelier, and C. Berset, “Use of a free-radical method to evaluate antioxidant activity,” Food Sci. Technol. (Campinas) 28, 25–30 (1995).

F. Della Rovere, A. Granata, M. Broccio, A. Zirilli, and G. Broccio, “Hemoglobin oxidative stress in cancer,” Anticancer Res. 15(5B), 2089–2095 (1995).
[PubMed]

M. Bryszewska, I. B. Zavodnik, A. Niekurzak, and K. Szosland, “Oxidative processes in red blood cells from normal and diabetic individuals,” Biochem. Mol. Biol. Int. 37(2), 345–354 (1995).
[PubMed]

1992 (2)

J. J. Gille and H. Joenje, “Cell culture models for oxidative stress: superoxide and hydrogen peroxide versus normobaric hyperoxia,” Mutat. Res. 275(3-6), 405–414 (1992).
[PubMed]

G. Damonte, L. Guida, A. Sdraffa, U. Benatti, E. Melloni, G. Forteleoni, T. Meloni, E. Carafoli, and A. De Flora, “Mechanisms of perturbation of erythrocyte calcium homeostasis in favism,” Cell Calcium 13(10), 649–658 (1992).
[PubMed]

1990 (3)

W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science 248(4951), 73–76 (1990).
[PubMed]

H.-J. Butt, E. K. Wolff, S. A. C. Gould, B. Dixon Northern, C. M. Peterson, and P. K. Hansma, “Imaging cells with the atomic force microscope,” J. Struct. Biol. 105(1-3), 54–61 (1990).
[PubMed]

S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

1987 (1)

H. N. Kirkman, S. Galiano, and G. F. Gaetani, “The function of catalase-bound NADPH,” J. Biol. Chem. 262(2), 660–666 (1987).
[PubMed]

1982 (1)

C. Pfafferott, H. J. Meiselman, and P. Hochstein, “The effect of malonyldialdehyde on erythrocyte deformability,” Blood 59(1), 12–15 (1982).
[PubMed]

Adamek-Guzik, T.

T. J. Guzik, R. Korbut, and T. Adamek-Guzik, “Nitric oxide and superoxide in inflammation and immune regulation,” J. Physiol. Pharmacol. 54(4), 469–487 (2003).
[PubMed]

Aguilar, M.

P. Prieto, M. Pineda, and M. Aguilar, “Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E,” Anal. Biochem. 269(2), 337–341 (1999).
[PubMed]

Ahn, H. Y.

H. Y. Ahn, K. E. Fairfull-Smith, B. J. Morrow, V. Lussini, B. Kim, M. V. Bondar, S. E. Bottle, and K. D. Belfield, “Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides,” J. Am. Chem. Soc. 134(10), 4721–4730 (2012).
[PubMed]

Akcay, F.

H. Kaynar, M. Meral, H. Turhan, M. Keles, G. Celik, and F. Akcay, “Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer,” Cancer Lett. 227(2), 133–139 (2005).
[PubMed]

Aksoy, Y.

Y. Aksoy, M. Balk, H. Ögüs, and N. Özer, “The mechanism of inhibition of human erythrocyte catalase by azide,” Turk. J. Biol. 28, 65–70 (2004).

Albrecht, T. R.

S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

Alfonso-García, A.

R. Datta, A. Alfonso-García, R. Cinco, and E. Gratton, “Fluorescence lifetime imaging of endogenous biomarker of oxidative stress,” Sci. Rep. 5, 9848 (2015).
[PubMed]

Al-Naama, L. M.

L. M. Al-Naama, M. K. Hassan, and J. K. Mehdi, “Association of erythrocytes antioxidant enzymes and their cofactors with markers of oxidative stress in patients with sickle cell anemia,” Qatar Med. J. 2015(2), 14 (2016).
[PubMed]

Aloyan, L. R.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

Amatuni, G. A.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Amirkhanyan, Z. G.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Arakelova, E.

G. Tsakanova, E. Arakelova, A. Soghoyan, and V. Ayvazyan, “Oxidative stress and post-ischemic inflammatory response in ischemic stroke complicated with diabetes mellitus type 2,” J. Biosci. Med. 3, 94–98 (2015).

Arakelova, E. A.

G. V. Tsakanova, V. A. Ayvazyan, A. S. Boyajyan, E. A. Arakelova, G. S. Grigoryan, A. A. Guevorkyan, and A. A. Mamikonyan, “Comparative analysis of the antioxidant system capacity and intensity of lipid peroxidation process in ischemic stroke complicated and none-complicated with diabetes mellitus type 2 and in diabetes mellitus type 2,” Bull. Exp. Biol. Med. 151(5), 496–500 (2011).
[PubMed]

Aroutiounian, R. M.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

Aslanyan, L. G.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

Aslyan, L. V.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Avagyan, V. Sh.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

Ayvazyan, V.

G. Tsakanova, E. Arakelova, A. Soghoyan, and V. Ayvazyan, “Oxidative stress and post-ischemic inflammatory response in ischemic stroke complicated with diabetes mellitus type 2,” J. Biosci. Med. 3, 94–98 (2015).

Ayvazyan, V. A.

G. V. Tsakanova, V. A. Ayvazyan, A. S. Boyajyan, E. A. Arakelova, G. S. Grigoryan, A. A. Guevorkyan, and A. A. Mamikonyan, “Comparative analysis of the antioxidant system capacity and intensity of lipid peroxidation process in ischemic stroke complicated and none-complicated with diabetes mellitus type 2 and in diabetes mellitus type 2,” Bull. Exp. Biol. Med. 151(5), 496–500 (2011).
[PubMed]

Baars, L. G.

C. T. Evelo, A. A. Spooren, R. A. Bisschops, L. G. Baars, and J. M. Neis, “Two mechanisms for toxic effects of hydroxylamines in human erythrocytes: involvement of free radicals and risk of potentiation,” Blood Cells Mol. Dis. 24(3), 280–295 (1998).
[PubMed]

Babayan, N. S.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

Bacskai, B. J.

M. E. McLellan, S. T. Kajdasz, B. T. Hyman, and B. J. Bacskai, “In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy,” J. Neurosci. 23(6), 2212–2217 (2003).
[PubMed]

Balk, M.

Y. Aksoy, M. Balk, H. Ögüs, and N. Özer, “The mechanism of inhibition of human erythrocyte catalase by azide,” Turk. J. Biol. 28, 65–70 (2004).

Banki, K.

A. Perl, P. Gergely, and K. Banki, “Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus,” Int. Rev. Immunol. 23(3-4), 293–313 (2004).
[PubMed]

Belfield, K. D.

H. Y. Ahn, K. E. Fairfull-Smith, B. J. Morrow, V. Lussini, B. Kim, M. V. Bondar, S. E. Bottle, and K. D. Belfield, “Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides,” J. Am. Chem. Soc. 134(10), 4721–4730 (2012).
[PubMed]

Benatti, U.

G. Damonte, L. Guida, A. Sdraffa, U. Benatti, E. Melloni, G. Forteleoni, T. Meloni, E. Carafoli, and A. De Flora, “Mechanisms of perturbation of erythrocyte calcium homeostasis in favism,” Cell Calcium 13(10), 649–658 (1992).
[PubMed]

Berset, C.

W. Brandwilliams, M. E. Cuvelier, and C. Berset, “Use of a free-radical method to evaluate antioxidant activity,” Food Sci. Technol. (Campinas) 28, 25–30 (1995).

Bhattacharjee, S.

A. I. Pogue, B. M. Jones, S. Bhattacharjee, M. E. Percy, Y. Zhao, and W. J. Lukiw, “Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a cell permeant tracer,” Int. J. Mol. Sci. 13(8), 9615–9626 (2012).
[PubMed]

Bisschops, R. A.

C. T. Evelo, A. A. Spooren, R. A. Bisschops, L. G. Baars, and J. M. Neis, “Two mechanisms for toxic effects of hydroxylamines in human erythrocytes: involvement of free radicals and risk of potentiation,” Blood Cells Mol. Dis. 24(3), 280–295 (1998).
[PubMed]

Bondar, M. V.

H. Y. Ahn, K. E. Fairfull-Smith, B. J. Morrow, V. Lussini, B. Kim, M. V. Bondar, S. E. Bottle, and K. D. Belfield, “Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides,” J. Am. Chem. Soc. 134(10), 4721–4730 (2012).
[PubMed]

Bottle, S. E.

H. Y. Ahn, K. E. Fairfull-Smith, B. J. Morrow, V. Lussini, B. Kim, M. V. Bondar, S. E. Bottle, and K. D. Belfield, “Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides,” J. Am. Chem. Soc. 134(10), 4721–4730 (2012).
[PubMed]

Boyajyan, A. S.

G. V. Tsakanova, V. A. Ayvazyan, A. S. Boyajyan, E. A. Arakelova, G. S. Grigoryan, A. A. Guevorkyan, and A. A. Mamikonyan, “Comparative analysis of the antioxidant system capacity and intensity of lipid peroxidation process in ischemic stroke complicated and none-complicated with diabetes mellitus type 2 and in diabetes mellitus type 2,” Bull. Exp. Biol. Med. 151(5), 496–500 (2011).
[PubMed]

Brandwilliams, W.

W. Brandwilliams, M. E. Cuvelier, and C. Berset, “Use of a free-radical method to evaluate antioxidant activity,” Food Sci. Technol. (Campinas) 28, 25–30 (1995).

Bridle, K. R.

H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
[PubMed]

Brinkmann, R.

Y. Miura, G. Huettmann, R. Orzekowsky-Schroeder, P. Steven, M. Szaszák, N. Koop, and R. Brinkmann, “Two-photon microscopy and fluorescence lifetime imaging of retinal pigment epithelial cells under oxidative stress,” Invest. Ophthalmol. Vis. Sci. 54(5), 3366–3377 (2013).
[PubMed]

Broccio, G.

F. Della Rovere, A. Granata, M. Broccio, A. Zirilli, and G. Broccio, “Hemoglobin oxidative stress in cancer,” Anticancer Res. 15(5B), 2089–2095 (1995).
[PubMed]

Broccio, M.

F. Della Rovere, A. Granata, M. Broccio, A. Zirilli, and G. Broccio, “Hemoglobin oxidative stress in cancer,” Anticancer Res. 15(5B), 2089–2095 (1995).
[PubMed]

Bryszewska, M.

M. Bryszewska, I. B. Zavodnik, A. Niekurzak, and K. Szosland, “Oxidative processes in red blood cells from normal and diabetic individuals,” Biochem. Mol. Biol. Int. 37(2), 345–354 (1995).
[PubMed]

Buniatyan, V. V.

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De Flora, A.

G. Damonte, L. Guida, A. Sdraffa, U. Benatti, E. Melloni, G. Forteleoni, T. Meloni, E. Carafoli, and A. De Flora, “Mechanisms of perturbation of erythrocyte calcium homeostasis in favism,” Cell Calcium 13(10), 649–658 (1992).
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Digman, M. A.

C. Stringari, A. Cinquin, O. Cinquin, M. A. Digman, P. J. Donovan, and E. Gratton, “Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue,” Proc. Natl. Acad. Sci. U.S.A. 108(33), 13582–13587 (2011).
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S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

Donovan, P. J.

C. Stringari, A. Cinquin, O. Cinquin, M. A. Digman, P. J. Donovan, and E. Gratton, “Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue,” Proc. Natl. Acad. Sci. U.S.A. 108(33), 13582–13587 (2011).
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M. C. Skala, K. M. Riching, A. Gendron-Fitzpatrick, J. Eickhoff, K. W. Eliceiri, J. G. White, and N. Ramanujam, “In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia,” Proc. Natl. Acad. Sci. U.S.A. 104(49), 19494–19499 (2007).
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M. C. Skala, K. M. Riching, A. Gendron-Fitzpatrick, J. Eickhoff, K. W. Eliceiri, J. G. White, and N. Ramanujam, “In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia,” Proc. Natl. Acad. Sci. U.S.A. 104(49), 19494–19499 (2007).
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Ghazaryan, N. G.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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H.-J. Butt, E. K. Wolff, S. A. C. Gould, B. Dixon Northern, C. M. Peterson, and P. K. Hansma, “Imaging cells with the atomic force microscope,” J. Struct. Biol. 105(1-3), 54–61 (1990).
[PubMed]

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F. Della Rovere, A. Granata, M. Broccio, A. Zirilli, and G. Broccio, “Hemoglobin oxidative stress in cancer,” Anticancer Res. 15(5B), 2089–2095 (1995).
[PubMed]

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R. Datta, A. Alfonso-García, R. Cinco, and E. Gratton, “Fluorescence lifetime imaging of endogenous biomarker of oxidative stress,” Sci. Rep. 5, 9848 (2015).
[PubMed]

C. Stringari, A. Cinquin, O. Cinquin, M. A. Digman, P. J. Donovan, and E. Gratton, “Phasor approach to fluorescence lifetime microscopy distinguishes different metabolic states of germ cells in a live tissue,” Proc. Natl. Acad. Sci. U.S.A. 108(33), 13582–13587 (2011).
[PubMed]

Grigoryan, A. H.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Grigoryan, B. A.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

Grigoryan, G. S.

G. V. Tsakanova, V. A. Ayvazyan, A. S. Boyajyan, E. A. Arakelova, G. S. Grigoryan, A. A. Guevorkyan, and A. A. Mamikonyan, “Comparative analysis of the antioxidant system capacity and intensity of lipid peroxidation process in ischemic stroke complicated and none-complicated with diabetes mellitus type 2 and in diabetes mellitus type 2,” Bull. Exp. Biol. Med. 151(5), 496–500 (2011).
[PubMed]

Grigoryan, N. E.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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Haroutyunian, S. G.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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F. Lang, K. S. Lang, P. A. Lang, S. M. Huber, and T. Wieder, “Mechanisms and significance of eryptosis,” Antioxid. Redox Signal. 8(7-8), 1183–1192 (2006).
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V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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M. E. McLellan, S. T. Kajdasz, B. T. Hyman, and B. J. Bacskai, “In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy,” J. Neurosci. 23(6), 2212–2217 (2003).
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K. Masamoto, H. Kawaguchi, H. Ito, and I. Kanno, “Dynamic two-photon imaging of cerebral microcirculation using fluorescently labeled red blood cells and plasma,” Adv. Exp. Med. Biol. 765, 163–168 (2013).
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K. Masamoto, H. Kawaguchi, H. Ito, and I. Kanno, “Dynamic two-photon imaging of cerebral microcirculation using fluorescently labeled red blood cells and plasma,” Adv. Exp. Med. Biol. 765, 163–168 (2013).
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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
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[PubMed]

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F. Long, J. Zhou, and H. Peng, “Visualization and analysis of 3D microscopic images,” PLOS Comput. Biol. 8(6), e1002519 (2012).
[PubMed]

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S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

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C. E. Pinzón-Díaz, J. V. Calderón-Salinas, M. M. Rosas-Flores, G. Hernández, A. López-Betancourt, and M. A. Quintanar-Escorza, “Eryptosis and oxidative damage in hypertensive and dyslipidemic patients,” Mol. Cell. Biochem. 434, 1–9 (2017).
[PubMed]

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R. Nowakowski, P. Luckham, and P. Winlove, “Imaging erythrocytes under physiological conditions by atomic force microscopy,” Biochim. Biophys. Acta 1514(2), 170–176 (2001).
[PubMed]

Lukiw, W. J.

A. I. Pogue, B. M. Jones, S. Bhattacharjee, M. E. Percy, Y. Zhao, and W. J. Lukiw, “Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a cell permeant tracer,” Int. J. Mol. Sci. 13(8), 9615–9626 (2012).
[PubMed]

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H. Y. Ahn, K. E. Fairfull-Smith, B. J. Morrow, V. Lussini, B. Kim, M. V. Bondar, S. E. Bottle, and K. D. Belfield, “Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides,” J. Am. Chem. Soc. 134(10), 4721–4730 (2012).
[PubMed]

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G. V. Tsakanova, V. A. Ayvazyan, A. S. Boyajyan, E. A. Arakelova, G. S. Grigoryan, A. A. Guevorkyan, and A. A. Mamikonyan, “Comparative analysis of the antioxidant system capacity and intensity of lipid peroxidation process in ischemic stroke complicated and none-complicated with diabetes mellitus type 2 and in diabetes mellitus type 2,” Bull. Exp. Biol. Med. 151(5), 496–500 (2011).
[PubMed]

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S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

Manukyan, P. S.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Mao, F.

F. Mao, Q. Xing, K. Wang, L. Lang, Zh. Wang, L. Chai, and Q. Wang, “Optical trapping of red blood cells and two-photon excitation-based photodynamic study using a femtosecond laser,” Opt. Commun. 256, 358–363 (2005).

Margaryan, I. N.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Markosyan, T. M.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Martínez, P.

C. de la Haba, J. R. Palacio, P. Martínez, and A. Morros, “Effect of oxidative stress on plasma membrane fluidity of THP-1 induced macrophages,” Biochim. Biophys. Acta 1828(2), 357–364 (2013).
[PubMed]

Martirosyan, N. V.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Martirosyan, N. W.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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K. Masamoto, H. Kawaguchi, H. Ito, and I. Kanno, “Dynamic two-photon imaging of cerebral microcirculation using fluorescently labeled red blood cells and plasma,” Adv. Exp. Med. Biol. 765, 163–168 (2013).
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[PubMed]

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K. B. Pandey, M. M. Mehdi, P. K. Maurya, and S. I. Rizvi, “Plasma protein oxidation and its correlation with antioxidant potential during human aging,” Dis. Markers 29(1), 31–36 (2010).
[PubMed]

Mehrabyan, Sh. A.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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G. Damonte, L. Guida, A. Sdraffa, U. Benatti, E. Melloni, G. Forteleoni, T. Meloni, E. Carafoli, and A. De Flora, “Mechanisms of perturbation of erythrocyte calcium homeostasis in favism,” Cell Calcium 13(10), 649–658 (1992).
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[PubMed]

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S. Mendiratta, Z. C. Qu, and J. M. May, “Erythrocyte ascorbate recycling: antioxidant effects in blood,” Free Radic. Biol. Med. 24(5), 789–797 (1998).
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H. Kaynar, M. Meral, H. Turhan, M. Keles, G. Celik, and F. Akcay, “Glutathione peroxidase, glutathione-S-transferase, catalase, xanthine oxidase, Cu-Zn superoxide dismutase activities, total glutathione, nitric oxide, and malondialdehyde levels in erythrocytes of patients with small cell and non-small cell lung cancer,” Cancer Lett. 227(2), 133–139 (2005).
[PubMed]

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K. B. Pandey, N. Mishra, and S. I. Rizvi, “Protein oxidation biomarkers in plasma of type 2 diabetic patients,” Clin. Biochem. 43(4-5), 508–511 (2010).
[PubMed]

Missie, J.

S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

Miura, Y.

Y. Miura, G. Huettmann, R. Orzekowsky-Schroeder, P. Steven, M. Szaszák, N. Koop, and R. Brinkmann, “Two-photon microscopy and fluorescence lifetime imaging of retinal pigment epithelial cells under oxidative stress,” Invest. Ophthalmol. Vis. Sci. 54(5), 3366–3377 (2013).
[PubMed]

Mkrtchyan, T. H.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Morros, A.

C. de la Haba, J. R. Palacio, P. Martínez, and A. Morros, “Effect of oxidative stress on plasma membrane fluidity of THP-1 induced macrophages,” Biochim. Biophys. Acta 1828(2), 357–364 (2013).
[PubMed]

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H. Y. Ahn, K. E. Fairfull-Smith, B. J. Morrow, V. Lussini, B. Kim, M. V. Bondar, S. E. Bottle, and K. D. Belfield, “Two-photon fluorescence microscopy imaging of cellular oxidative stress using profluorescent nitroxides,” J. Am. Chem. Soc. 134(10), 4721–4730 (2012).
[PubMed]

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S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

Muradyan, L. Kh.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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[PubMed]

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[PubMed]

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Y. Niihara, J. Ge, O. Shalev, H. Wu, A. Tu, and K. R. Tanaka, “Desferrioxamine decreases NAD redox potential of intact red blood cells: evidence for desferrioxamine as an inducer of oxidant stress in red blood cells,” BMC Clin. Pharmacol. 2, 8 (2002).
[PubMed]

Nikogosyan, G. H.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Nowakowski, R.

R. Nowakowski, P. Luckham, and P. Winlove, “Imaging erythrocytes under physiological conditions by atomic force microscopy,” Biochim. Biophys. Acta 1514(2), 170–176 (2001).
[PubMed]

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Y. Aksoy, M. Balk, H. Ögüs, and N. Özer, “The mechanism of inhibition of human erythrocyte catalase by azide,” Turk. J. Biol. 28, 65–70 (2004).

Orzekowsky-Schroeder, R.

Y. Miura, G. Huettmann, R. Orzekowsky-Schroeder, P. Steven, M. Szaszák, N. Koop, and R. Brinkmann, “Two-photon microscopy and fluorescence lifetime imaging of retinal pigment epithelial cells under oxidative stress,” Invest. Ophthalmol. Vis. Sci. 54(5), 3366–3377 (2013).
[PubMed]

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Y. Aksoy, M. Balk, H. Ögüs, and N. Özer, “The mechanism of inhibition of human erythrocyte catalase by azide,” Turk. J. Biol. 28, 65–70 (2004).

Palacio, J. R.

C. de la Haba, J. R. Palacio, P. Martínez, and A. Morros, “Effect of oxidative stress on plasma membrane fluidity of THP-1 induced macrophages,” Biochim. Biophys. Acta 1828(2), 357–364 (2013).
[PubMed]

Pandey, K. B.

K. B. Pandey, N. Mishra, and S. I. Rizvi, “Protein oxidation biomarkers in plasma of type 2 diabetic patients,” Clin. Biochem. 43(4-5), 508–511 (2010).
[PubMed]

K. B. Pandey, M. M. Mehdi, P. K. Maurya, and S. I. Rizvi, “Plasma protein oxidation and its correlation with antioxidant potential during human aging,” Dis. Markers 29(1), 31–36 (2010).
[PubMed]

Peng, H.

F. Long, J. Zhou, and H. Peng, “Visualization and analysis of 3D microscopic images,” PLOS Comput. Biol. 8(6), e1002519 (2012).
[PubMed]

Percy, M. E.

A. I. Pogue, B. M. Jones, S. Bhattacharjee, M. E. Percy, Y. Zhao, and W. J. Lukiw, “Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2′,7′-Dichlorofluorescein Diacetate (Carboxy-DCFDA) as a cell permeant tracer,” Int. J. Mol. Sci. 13(8), 9615–9626 (2012).
[PubMed]

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[PubMed]

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S. A. C. Gould, B. Drake, C. B. Prater, A. L. Weisenhorn, S. Manne, H. G. Hansma, P. K. Hansma, J. Missie, M. Longmire, V. Elings, B. Dixon Northern, B. Mukergee, C. M. Peterson, W. Stoeckenius, T. R. Albrecht, and C. F. Quate, “From atoms to integrated circuit chips, blood cells, and bacteria with the atomic force microscope,” J. Vac. Sci. Technol. A 8, 369–373 (1990).

H.-J. Butt, E. K. Wolff, S. A. C. Gould, B. Dixon Northern, C. M. Peterson, and P. K. Hansma, “Imaging cells with the atomic force microscope,” J. Struct. Biol. 105(1-3), 54–61 (1990).
[PubMed]

Petrosyan, A. G.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

Petrosyan, V. H.

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
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V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Tsakanov, V. M.

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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G. Tsakanova, E. Arakelova, A. Soghoyan, and V. Ayvazyan, “Oxidative stress and post-ischemic inflammatory response in ischemic stroke complicated with diabetes mellitus type 2,” J. Biosci. Med. 3, 94–98 (2015).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

G. V. Tsakanova, V. A. Ayvazyan, A. S. Boyajyan, E. A. Arakelova, G. S. Grigoryan, A. A. Guevorkyan, and A. A. Mamikonyan, “Comparative analysis of the antioxidant system capacity and intensity of lipid peroxidation process in ischemic stroke complicated and none-complicated with diabetes mellitus type 2 and in diabetes mellitus type 2,” Bull. Exp. Biol. Med. 151(5), 496–500 (2011).
[PubMed]

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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[PubMed]

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[PubMed]

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
[PubMed]

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F. Mao, Q. Xing, K. Wang, L. Lang, Zh. Wang, L. Chai, and Q. Wang, “Optical trapping of red blood cells and two-photon excitation-based photodynamic study using a femtosecond laser,” Opt. Commun. 256, 358–363 (2005).

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Y. Niihara, J. Ge, O. Shalev, H. Wu, A. Tu, and K. R. Tanaka, “Desferrioxamine decreases NAD redox potential of intact red blood cells: evidence for desferrioxamine as an inducer of oxidant stress in red blood cells,” BMC Clin. Pharmacol. 2, 8 (2002).
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F. Mao, Q. Xing, K. Wang, L. Lang, Zh. Wang, L. Chai, and Q. Wang, “Optical trapping of red blood cells and two-photon excitation-based photodynamic study using a femtosecond laser,” Opt. Commun. 256, 358–363 (2005).

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H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
[PubMed]

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V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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[PubMed]

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H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
[PubMed]

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V. M. Tsakanov, G. A. Amatuni, Z. G. Amirkhanyan, L. V. Aslyan, V. Sh. Avagyan, V. A. Danielyan, H. D. Davtyan, V. S. Dekhtiarov, K. L. Gevorgyan, N. G. Ghazaryan, B. A. Grigoryan, A. H. Grigoryan, L. S. Hakobyan, S. G. Haroutiunian, M. I. Ivanyan, V. G. Khachatryan, E. M. Laziev, P. S. Manukyan, I. N. Margaryan, T. M. Markosyan, N. V. Martirosyan, Sh. A. Mehrabyan, T. H. Mkrtchyan, L. Kh. Muradyan, G. H. Nikogosyan, V. H. Petrosyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, H. A. Toneyan, A. V. Tsakanian, T. L. Vardanyan, A. S. Vardanyan, A. S. Yeremyan, S. V. Zakaryan, and G. S. Zanyan, “AREAL test facility for advanced accelerator and radiation source concepts,” Nucl. Instrum. Methods Phys. Res. A 829, 284–290 (2016).

Zanyan, G. S.

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V. M. Tsakanov, R. M. Aroutiounian, G. A. Amatuni, L. R. Aloyan, L. G. Aslanyan, V. Sh. Avagyan, N. S. Babayan, V. V. Buniatyan, Y. B. Dalyan, H. D. Davtyan, M. V. Derdzyan, B. A. Grigoryan, N. E. Grigoryan, L. S. Hakobyan, S. G. Haroutyunian, V. V. Harutiunyan, K. L. Hovhannesyan, V. G. Khachatryan, N. W. Martirosyan, G. S. Melikyan, A. G. Petrosyan, V. H. Petrosyan, A. A. Sahakyan, V. V. Sahakyan, A. A. Sargsyan, A. S. Simonyan, S. Sh. Tatikyan, G. V. Tsakanova, E. Tsovyan, A. S. Vardanyan, V. V. Vardanyan, A. S. Yeremyan, H. N. Yeritsyan, and G. S. Zanyan, “AREAL low energy electron beam applications in life and materials sciences,” Nucl. Instrum. Methods Phys. Res. A 829, 248–253 (2016).

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H. Wang, R. Zhang, K. R. Bridle, A. Jayachandran, J. A. Thomas, W. Zhang, J. Yuan, Z. P. Xu, D. H. Crawford, X. Liang, X. Liu, and M. S. Roberts, “Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury,” Sci. Rep. 7, 45374 (2017).
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Figures (7)

Fig. 1
Fig. 1

A) The two-photon fluorescence laser scanning microscopy system scheme used to capture microscopy images of RBCs: M1, M2, M3 – Mirrors; PC – Polarizing cube/beam splitter; PM – Power measurement; BA – Beam adjustment mirror; DM – Dichroic mirror with cutoff wavelength of 585 nm and average transmission of 90-95%; PMP1, PMP2 – Photomultipliers; B) The transmission spectrum of the green filter used for the detection of carboxy-DCFDA fluorescence.

Fig. 2
Fig. 2

The percentage of RBCs hemolysis in different conditions of oxidative stress (0.05%, 0.1%, 0.2%, 0.3%, 0.4% and 0.5%).

Fig. 3
Fig. 3

Two-photon fluorescence intensity images of RBCs treated with different H2O2 concentrations.

Fig. 4
Fig. 4

Carboxy-DCFDA fluorescence intensities of the images presented in Fig. 3. Fluorescent intensities are represented in arbitrary units (AU).

Fig. 5
Fig. 5

(A and B) Two-photon fluorescence intensity images of initially (before the H2O2 exposure) crenated and excluded RBCs samples treated with carboxy-DCFDA; 3D deconvolution of two-photon microscopy z-stack images of crenated (C) and normal cells (D).

Fig. 6
Fig. 6

Two-photon fluorescence intensity images of intact RBCs and those exposed to oxidative stress. The first row: images taken from the samples with intact RBCs (Fig. 6(A)-6(D)), the second row: samples with RBCs exposed to oxidative stress (Fig. 6(A´)-6(D´)). A and A´) RBCs without carboxy-DCFDA in bright field; B and B´) RBCs without carboxy-DCFDA in two-photon excitation; C and C´) RBCs with carboxy-DCFDA in bright field; D and D´) RBCs with carboxy-DCFDA in two-photon excitation.

Fig. 7
Fig. 7

The mean values of carboxy-DCFDA fluorescence intensities in samples with intact RBCs, RBCs with carboxy-DCFDA and RBCs with carboxy-DCFDA and H2O2. Each data point represents the mean intensities of single images in triplicates. Overall, 180 images were acquired (20 in each group; triplicate for each condition). In average, 30.7 ± 13.15 and 35.8 ± 14.12 (mean ± SD) cells have been counted in the ROIs for RBCs with and without H2O2.