Abstract

To resolve fine structures of biological systems like neurons, it is required to realize microscopic imaging with sufficient spatial resolution in three dimensional systems. With regular optical imaging systems, high lateral resolution is accessible while high axial resolution is hard to achieve in a large volume. We introduce an imaging system for high 3D resolution fluorescence imaging of large volume tissues. Selective plane illumination was adopted to provide high axial resolution. A scientific CMOS working in sub-array mode kept the imaging area in the sample surface, which restrained the adverse effect of aberrations caused by inclined illumination. Plastic embedding and precise mechanical sectioning extended the axial range and eliminated distortion during the whole imaging process. The combination of these techniques enabled 3D high resolution imaging of large tissues. Fluorescent bead imaging showed resolutions of 0.59 μm, 0.47μm, and 0.59 μm in the x, y, and z directions, respectively. Data acquired from the volume sample of brain tissue demonstrated the applicability of this imaging system. Imaging of different depths showed uniform performance where details could be recognized in either the near-soma area or terminal area, and fine structures of neurons could be seen in both the xy and xz sections.

© 2017 Optical Society of America

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2017 (2)

R. M. Power and J. Huisken, “A guide to light-sheet fluorescence microscopy for multiscale imaging,” Nat. Methods 14(4), 360–373 (2017).
[Crossref] [PubMed]

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

2016 (7)

L. A. Royer, W. C. Lemon, R. K. Chhetri, Y. Wan, M. Coleman, E. W. Myers, and P. J. Keller, “Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms,” Nat. Biotechnol. 34(12), 1267–1278 (2016).
[Crossref] [PubMed]

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

M. N. Economon, N. G. Clack, L. D. Levis, C. R. Gerfen, K. Svoboda, E. W. Myers, and J. Chandrashekar, “A platform for brain-wide imaging and reconstruction of individual neurons,” eLife 2016, 5 (2016).

P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
[Crossref] [PubMed]

J. D. Manton and E. J. Rees, “triSPIM: light sheet microscopy with isotropic super-resolution,” Opt. Lett. 41(18), 4170–4173 (2016).
[Crossref] [PubMed]

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
[Crossref] [PubMed]

2015 (3)

R. K. Chhetri, F. Amat, Y. Wan, B. Höckendorf, W. C. Lemon, and P. J. Keller, “Whole-animal functional and developmental imaging with isotropic spatial resolution,” Nat. Methods 12(12), 1171–1178 (2015).
[Crossref] [PubMed]

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
[Crossref] [PubMed]

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free Subcellular Imaging with Axially Swept Light Sheet Microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
[Crossref] [PubMed]

2014 (5)

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
[Crossref] [PubMed]

E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
[Crossref] [PubMed]

R. Tomer, L. Ye, B. Hsueh, and K. Deisseroth, “Advanced CLARITY for rapid and high-resolution imaging of intact tissues,” Nat. Protoc. 9(7), 1682–1697 (2014).
[Crossref] [PubMed]

2013 (4)

T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
[Crossref] [PubMed]

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

Z. Yang, B. Hu, Y. Zhang, Q. Luo, and H. Gong, “Development of a Plastic Embedding Method for Large-Volume and Fluorescent-Protein-Expressing Tissues,” PLoS One 8(4), e60877 (2013).
[Crossref] [PubMed]

D. Turaga and T. E. Holy, “Aberrations and their correction in light-sheet microscopy: a low-dimensional parametrization,” Biomed. Opt. Express 4(9), 1654–1661 (2013).
[Crossref] [PubMed]

2012 (4)

C. Bourgenot, C. D. Saunter, J. M. Taylor, J. M. Girkin, and G. D. Love, “3D adaptive optics in a light sheet microscope,” Opt. Express 20(12), 13252–13261 (2012).
[Crossref] [PubMed]

C. J. Niedworok, I. Schwarz, J. Ledderose, G. Giese, K. K. Conzelmann, and M. K. Schwarz, “Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy,” Cell Reports 2(5), 1375–1386 (2012).
[Crossref] [PubMed]

L. Silvestri, A. Bria, L. Sacconi, G. Iannello, and F. S. Pavone, “Confocal light sheet microscopy: micron-scale neuroanatomy of the entire mouse brain,” Opt. Express 20(18), 20582–20598 (2012).
[Crossref] [PubMed]

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

2011 (1)

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

2010 (1)

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

2008 (1)

2007 (1)

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Abe, T.

E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
[Crossref] [PubMed]

Amat, F.

R. K. Chhetri, F. Amat, Y. Wan, B. Höckendorf, W. C. Lemon, and P. J. Keller, “Whole-animal functional and developmental imaging with isotropic spatial resolution,” Nat. Methods 12(12), 1171–1178 (2015).
[Crossref] [PubMed]

Arganda-Carreras, I.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

Avants, B. B.

W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
[Crossref] [PubMed]

Bahlmann, K.

T. Ragan, L. R. Kadiri, K. U. Venkataraju, K. Bahlmann, J. Sutin, J. Taranda, I. Arganda-Carreras, Y. Kim, H. S. Seung, and P. Osten, “Serial two-photon tomography for automated ex vivo mouse brain imaging,” Nat. Methods 9(3), 255–258 (2012).
[Crossref] [PubMed]

Balázs, B.

P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

Bao, Z.

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
[Crossref] [PubMed]

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
[Crossref] [PubMed]

Becker, K.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Bembenek, J. N.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Besir, C.

P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

Betzig, E.

W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
[Crossref] [PubMed]

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Böhme, R.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Bokinsky, A.

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
[Crossref] [PubMed]

Bouchard, M. B.

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
[Crossref] [PubMed]

Bourgenot, C.

Bria, A.

Brown, T. A.

W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
[Crossref] [PubMed]

Bruno, R. M.

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
[Crossref] [PubMed]

Chandrashekar, J.

M. N. Economon, N. G. Clack, L. D. Levis, C. R. Gerfen, K. Svoboda, E. W. Myers, and J. Chandrashekar, “A platform for brain-wide imaging and reconstruction of individual neurons,” eLife 2016, 5 (2016).

Chandris, P.

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
[Crossref] [PubMed]

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
[Crossref] [PubMed]

Chen, B. C.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

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L. A. Royer, W. C. Lemon, R. K. Chhetri, Y. Wan, M. Coleman, E. W. Myers, and P. J. Keller, “Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms,” Nat. Biotechnol. 34(12), 1267–1278 (2016).
[Crossref] [PubMed]

R. K. Chhetri, F. Amat, Y. Wan, B. Höckendorf, W. C. Lemon, and P. J. Keller, “Whole-animal functional and developmental imaging with isotropic spatial resolution,” Nat. Methods 12(12), 1171–1178 (2015).
[Crossref] [PubMed]

Choi, J. M.

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

Christensen, R.

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
[Crossref] [PubMed]

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
[Crossref] [PubMed]

Clack, N. G.

M. N. Economon, N. G. Clack, L. D. Levis, C. R. Gerfen, K. Svoboda, E. W. Myers, and J. Chandrashekar, “A platform for brain-wide imaging and reconstruction of individual neurons,” eLife 2016, 5 (2016).

Coleman, M.

L. A. Royer, W. C. Lemon, R. K. Chhetri, Y. Wan, M. Coleman, E. W. Myers, and P. J. Keller, “Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms,” Nat. Biotechnol. 34(12), 1267–1278 (2016).
[Crossref] [PubMed]

Colón-Ramos, D.

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
[Crossref] [PubMed]

Colón-Ramos, D. A.

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
[Crossref] [PubMed]

Conzelmann, K. K.

C. J. Niedworok, I. Schwarz, J. Ledderose, G. Giese, K. K. Conzelmann, and M. K. Schwarz, “Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy,” Cell Reports 2(5), 1375–1386 (2012).
[Crossref] [PubMed]

Danuser, G.

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free Subcellular Imaging with Axially Swept Light Sheet Microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
[Crossref] [PubMed]

Davidson, M. W.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

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P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

Dean, K. M.

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free Subcellular Imaging with Axially Swept Light Sheet Microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
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Deininger, K.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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Deisseroth, K.

R. Tomer, L. Ye, B. Hsueh, and K. Deisseroth, “Advanced CLARITY for rapid and high-resolution imaging of intact tissues,” Nat. Protoc. 9(7), 1682–1697 (2014).
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H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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Ding, W.

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
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Dodt, H. U.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Duncan, W.

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
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Economon, M. N.

M. N. Economon, N. G. Clack, L. D. Levis, C. R. Gerfen, K. Svoboda, E. W. Myers, and J. Chandrashekar, “A platform for brain-wide imaging and reconstruction of individual neurons,” eLife 2016, 5 (2016).

Eder, M.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
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Engelhardt, J.

P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

English, B. P.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Feng, Z.

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

Fiolka, R.

K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free Subcellular Imaging with Axially Swept Light Sheet Microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
[Crossref] [PubMed]

Fraser, S. E.

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

Fritz-Laylin, L.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Gandler, W.

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
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Gang, Y. D.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Gerfen, C. R.

M. N. Economon, N. G. Clack, L. D. Levis, C. R. Gerfen, K. Svoboda, E. W. Myers, and J. Chandrashekar, “A platform for brain-wide imaging and reconstruction of individual neurons,” eLife 2016, 5 (2016).

Giese, G.

C. J. Niedworok, I. Schwarz, J. Ledderose, G. Giese, K. K. Conzelmann, and M. K. Schwarz, “Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy,” Cell Reports 2(5), 1375–1386 (2012).
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Girkin, J. M.

Gong, H.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
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H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
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Z. Yang, B. Hu, Y. Zhang, Q. Luo, and H. Gong, “Development of a Plastic Embedding Method for Large-Volume and Fluorescent-Protein-Expressing Tissues,” PLoS One 8(4), e60877 (2013).
[Crossref] [PubMed]

T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
[Crossref] [PubMed]

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
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Grill, S. W.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Grimm, J. B.

W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
[Crossref] [PubMed]

Grueber, W. B.

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
[Crossref] [PubMed]

Guo, C.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

Guo, M.

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
[Crossref] [PubMed]

Hammer, J. A.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Hanne, J.

P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

Hell, S. W.

P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

Hillman, E. M. C.

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
[Crossref] [PubMed]

Höckendorf, B.

R. K. Chhetri, F. Amat, Y. Wan, B. Höckendorf, W. C. Lemon, and P. J. Keller, “Whole-animal functional and developmental imaging with isotropic spatial resolution,” Nat. Methods 12(12), 1171–1178 (2015).
[Crossref] [PubMed]

Holy, T. E.

Hoyer, P.

P. Hoyer, G. de Medeiros, B. Balázs, N. Norlin, C. Besir, J. Hanne, H. G. Kräusslich, J. Engelhardt, S. J. Sahl, S. W. Hell, and L. Hufnagel, “Breaking the diffraction limit of light-sheet fluorescence microscopy by RESOLFT,” Proc. Natl. Acad. Sci. U.S.A. 113(13), 3442–3446 (2016).
[Crossref] [PubMed]

Hsueh, B.

R. Tomer, L. Ye, B. Hsueh, and K. Deisseroth, “Advanced CLARITY for rapid and high-resolution imaging of intact tissues,” Nat. Protoc. 9(7), 1682–1697 (2014).
[Crossref] [PubMed]

Hu, B.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

Z. Yang, B. Hu, Y. Zhang, Q. Luo, and H. Gong, “Development of a Plastic Embedding Method for Large-Volume and Fluorescent-Protein-Expressing Tissues,” PLoS One 8(4), e60877 (2013).
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Hufnagel, L.

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Jährling, N.

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B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

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L. A. Royer, W. C. Lemon, R. K. Chhetri, Y. Wan, M. Coleman, E. W. Myers, and P. J. Keller, “Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms,” Nat. Biotechnol. 34(12), 1267–1278 (2016).
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B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
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T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
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Kumar, A.

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A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
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Lacefield, C.

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
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W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
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C. J. Niedworok, I. Schwarz, J. Ledderose, G. Giese, K. K. Conzelmann, and M. K. Schwarz, “Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy,” Cell Reports 2(5), 1375–1386 (2012).
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W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
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B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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L. A. Royer, W. C. Lemon, R. K. Chhetri, Y. Wan, M. Coleman, E. W. Myers, and P. J. Keller, “Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms,” Nat. Biotechnol. 34(12), 1267–1278 (2016).
[Crossref] [PubMed]

R. K. Chhetri, F. Amat, Y. Wan, B. Höckendorf, W. C. Lemon, and P. J. Keller, “Whole-animal functional and developmental imaging with isotropic spatial resolution,” Nat. Methods 12(12), 1171–1178 (2015).
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Li, A.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
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H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
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T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
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H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
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A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
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H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
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Li, L. H.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Li, S.

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
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Li, X.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
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Li, Y.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
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Lippincott-Schwartz, J.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Liu, J.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
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Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Liu, Q.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
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Liu, X. L.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Liu, Z.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Love, G. D.

Luo, Q.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
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Z. Yang, B. Hu, Y. Zhang, Q. Luo, and H. Gong, “Development of a Plastic Embedding Method for Large-Volume and Fluorescent-Protein-Expressing Tissues,” PLoS One 8(4), e60877 (2013).
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T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
[Crossref] [PubMed]

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Luo, Q. M.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Lv, X.

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
[Crossref] [PubMed]

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

Lv, X. H.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Mann, R. S.

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
[Crossref] [PubMed]

Manton, J. D.

Mauch, C. P.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

McAuliffe, M.

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
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McCreedy, E.

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
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Mendes, C. S.

M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
[Crossref] [PubMed]

Milkie, D. E.

W. R. Legant, L. Shao, J. B. Grimm, T. A. Brown, D. E. Milkie, B. B. Avants, L. D. Lavis, and E. Betzig, “High-density three-dimensional localization microscopy across large volumes,” Nat. Methods 13(4), 359–365 (2016).
[Crossref] [PubMed]

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Mimori-Kiyosue, Y.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
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Mitchell, D. M.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Miyawaki, A.

E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
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Moyle, M.

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M. N. Economon, N. G. Clack, L. D. Levis, C. R. Gerfen, K. Svoboda, E. W. Myers, and J. Chandrashekar, “A platform for brain-wide imaging and reconstruction of individual neurons,” eLife 2016, 5 (2016).

L. A. Royer, W. C. Lemon, R. K. Chhetri, Y. Wan, M. Coleman, E. W. Myers, and P. J. Keller, “Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms,” Nat. Biotechnol. 34(12), 1267–1278 (2016).
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Wu, X. S.

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

Wu, Y.

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
[Crossref] [PubMed]

A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
[Crossref] [PubMed]

Xiong, B.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

Xiong, H.

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

Xiong, H. Q.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Xu, D.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

Xu, T.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

Yamaguchi, S.

E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
[Crossref] [PubMed]

Yan, C.

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Yang, T.

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

Yang, Z.

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

Z. Yang, B. Hu, Y. Zhang, Q. Luo, and H. Gong, “Development of a Plastic Embedding Method for Large-Volume and Fluorescent-Protein-Expressing Tissues,” PLoS One 8(4), e60877 (2013).
[Crossref] [PubMed]

T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
[Crossref] [PubMed]

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

Yang, Z. Q.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Ye, L.

R. Tomer, L. Ye, B. Hsueh, and K. Deisseroth, “Advanced CLARITY for rapid and high-resolution imaging of intact tissues,” Nat. Protoc. 9(7), 1682–1697 (2014).
[Crossref] [PubMed]

Yokota, H.

E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
[Crossref] [PubMed]

Yokoyama, C.

E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
[Crossref] [PubMed]

Yuan, J.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

Zeng, S.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
[Crossref] [PubMed]

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
[Crossref] [PubMed]

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Zeng, S. Q.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Zhang, B.

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
[Crossref] [PubMed]

Zhang, Y.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

Z. Yang, B. Hu, Y. Zhang, Q. Luo, and H. Gong, “Development of a Plastic Embedding Method for Large-Volume and Fluorescent-Protein-Expressing Tissues,” PLoS One 8(4), e60877 (2013).
[Crossref] [PubMed]

Zheng, T.

Zhong, Q.

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
[Crossref] [PubMed]

Zhou, H. F.

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Zhou, Z.

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

T. Zheng, Z. Yang, A. Li, X. Lv, Z. Zhou, X. Wang, X. Qi, S. Li, Q. Luo, H. Gong, and S. Zeng, “Visualization of brain circuits using two-photon fluorescence micro-optical sectioning tomography,” Opt. Express 21(8), 9839–9850 (2013).
[Crossref] [PubMed]

Zhu, M.

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

Zieglgänsberger, W.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Biol. Bull. (1)

A. Kumar, R. Christensen, M. Guo, P. Chandris, W. Duncan, Y. Wu, A. Santella, M. Moyle, P. W. Winter, D. Colón-Ramos, Z. Bao, and H. Shroff, “Using Stage- and Slit-Scanning to Improve Contrast and Optical Sectioning in Dual-View Inverted Light Sheet Microscopy (diSPIM),” Biol. Bull. 231(1), 26–39 (2016).
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Biomed. Opt. Express (1)

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K. M. Dean, P. Roudot, E. S. Welf, G. Danuser, and R. Fiolka, “Deconvolution-free Subcellular Imaging with Axially Swept Light Sheet Microscopy,” Biophys. J. 108(12), 2807–2815 (2015).
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Cell (1)

E. A. Susaki, K. Tainaka, D. Perrin, F. Kishino, T. Tawara, T. M. Watanabe, C. Yokoyama, H. Onoe, M. Eguchi, S. Yamaguchi, T. Abe, H. Kiyonari, Y. Shimizu, A. Miyawaki, H. Yokota, and H. R. Ueda, “Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis,” Cell 157(3), 726–739 (2014).
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Cell Reports (1)

C. J. Niedworok, I. Schwarz, J. Ledderose, G. Giese, K. K. Conzelmann, and M. K. Schwarz, “Charting Monosynaptic Connectivity Maps by Two-Color Light-Sheet Fluorescence Microscopy,” Cell Reports 2(5), 1375–1386 (2012).
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eLife (1)

M. N. Economon, N. G. Clack, L. D. Levis, C. R. Gerfen, K. Svoboda, E. W. Myers, and J. Chandrashekar, “A platform for brain-wide imaging and reconstruction of individual neurons,” eLife 2016, 5 (2016).

Front Neurosci. (1)

Y. D. Gang, H. F. Zhou, Y. Jia, L. Liu, X. L. Liu, G. Rao, L. H. Li, X. J. Wang, X. H. Lv, H. Q. Xiong, Z. Q. Yang, Q. M. Luo, H. Gong, and S. Q. Zeng, “Embedding and Chemical Reactivation of Green Fluorescent Protein in the Whole Mouse Brain for Optical Micro-Imaging,” Front Neurosci. 11, 121 (2017).

Nat. Biotechnol. (1)

L. A. Royer, W. C. Lemon, R. K. Chhetri, Y. Wan, M. Coleman, E. W. Myers, and P. J. Keller, “Adaptive light-sheet microscopy for long-term, high-resolution imaging in living organisms,” Nat. Biotechnol. 34(12), 1267–1278 (2016).
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Nat. Commun. (2)

H. Xiong, Z. Zhou, M. Zhu, X. Lv, A. Li, S. Li, L. Li, T. Yang, S. Wang, Z. Yang, T. Xu, Q. Luo, H. Gong, and S. Zeng, “Chemical reactivation of quenched fluorescent protein molecules enables resin-embedded fluorescence microimaging,” Nat. Commun. 5, 3992 (2014).
[Crossref] [PubMed]

H. Gong, D. Xu, J. Yuan, X. Li, C. Guo, J. Peng, Y. Li, L. A. Schwarz, A. Li, B. Hu, B. Xiong, Q. Sun, Y. Zhang, J. Liu, Q. Zhong, T. Xu, S. Zeng, and Q. Luo, “High-throughput dual-colour precision imaging for brain-wide connectome with cytoarchitectonic landmarks at the cellular level,” Nat. Commun. 7, 12142 (2016).
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Nat. Methods (6)

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H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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M. B. Bouchard, V. Voleti, C. S. Mendes, C. Lacefield, W. B. Grueber, R. S. Mann, R. M. Bruno, and E. M. C. Hillman, “Swept confocally-aligned planar excitation (SCAPE) microscopy for high speed volumetric imaging of behaving organisms,” Nat. Photonics 9(2), 113–119 (2015).
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R. Tomer, L. Ye, B. Hsueh, and K. Deisseroth, “Advanced CLARITY for rapid and high-resolution imaging of intact tissues,” Nat. Protoc. 9(7), 1682–1697 (2014).
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A. Kumar, Y. Wu, R. Christensen, P. Chandris, W. Gandler, E. McCreedy, A. Bokinsky, D. A. Colón-Ramos, Z. Bao, M. McAuliffe, G. Rondeau, and H. Shroff, “Dual-view plane illumination microscopy for rapid and spatially isotropic imaging,” Nat. Protoc. 9(11), 2555–2573 (2014).
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Neuroimage (1)

H. Gong, S. Zeng, C. Yan, X. Lv, Z. Yang, T. Xu, Z. Feng, W. Ding, X. Qi, A. Li, J. Wu, and Q. Luo, “Continuously tracing brain-wide long-distance axonal projections in mice at a one-micron voxel resolution,” Neuroimage 74, 87–98 (2013).
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Opt. Express (3)

Opt. Lett. (2)

PLoS One (1)

Z. Yang, B. Hu, Y. Zhang, Q. Luo, and H. Gong, “Development of a Plastic Embedding Method for Large-Volume and Fluorescent-Protein-Expressing Tissues,” PLoS One 8(4), e60877 (2013).
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Science (2)

B. C. Chen, W. R. Legant, K. Wang, L. Shao, D. E. Milkie, M. W. Davidson, C. Janetopoulos, X. S. Wu, J. A. Hammer, Z. Liu, B. P. English, Y. Mimori-Kiyosue, D. P. Romero, A. T. Ritter, J. Lippincott-Schwartz, L. Fritz-Laylin, R. D. Mullins, D. M. Mitchell, J. N. Bembenek, A. C. Reymann, R. Böhme, S. W. Grill, J. T. Wang, G. Seydoux, U. S. Tulu, D. P. Kiehart, and E. Betzig, “Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution,” Science 346(6208), 1257998 (2014).
[Crossref] [PubMed]

A. Li, H. Gong, B. Zhang, Q. Wang, C. Yan, J. Wu, Q. Liu, S. Zeng, and Q. Luo, “Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain,” Science 330(6009), 1404–1408 (2010).
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Other (1)

M. Stefaniuk, E. J. Gualda, M. Pawlowska, D. Legutko, P. Matryba, P. Koza, W. Konopka, D. Owczarek, M. Wawrzyniak, P. Loza-Alvarez, and L. Kaczmarek, “Light-sheet microscopy imaging of a whole cleared rat brain with Thy1-GFP transgene,” Sci Rep-Uk 6 (2016).

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Figures (5)

Fig. 1
Fig. 1 (a) Optical scheme of selective plane illumination imaging system for extended large tissue. (b) Stage-scanning strategy of each layer for large tissue imaging. (c) Schematic representation of illumination with short Rayleigh range and detection with a sCMOS in sub-array mode. 32 lines activated pixels equals 5.2 μm in object space. The imaging thickness of one layer is 5.2 μm/sin45° = 3.7 μm. Sectioning thickness is slight less than imaging depth to ensure signal integrity. The activated pixels can be decreased to 16/8 lines for higher imaging quality, the effective light-sheet width and sectioning thickness should change accordingly. (d) Image reconstruction of oblique raw data.
Fig. 2
Fig. 2 Gaussian fit of 200 nm fluorescence beads signal intensity in x, y, and z direction. N=5.
Fig. 3
Fig. 3 (a) Aberration caused by mismatch of refraction index. (b) Zemax simulation results of illumination beam waists and detection PSFs (inserts) in different invasion depths, n1 = 1.45, n2 = 1.33. Size of inserts, 1.6 × 1.6 μm. (c) Intensity curves along z’ direction lines in each result of (b). Scale bar, 5 μm.
Fig. 4
Fig. 4 Inclined selective plane illumination imaging and confocal imaging results using Thy1 GFP mouse. (a) xy section and xz section of selective plane illumination imaging result (12 imaging layers with 1.8 μm intervals). Inserts show enlarged views of neural fiber near soma and dendrite terminal area respectively. Normalized intense curves of the lines in xz sections shows at the bottom. (b) Similar to (a), except for the result is acquired by confocal microscopy (90 imaging planes with 0.23 μm axial intervals). Scale bar; xy sections, 100 μm, inserts and xz sections, 10 μm.
Fig. 5
Fig. 5 Volume imaging result of mice brain tissue. (a) 1800 × 1000 × 1000 μm3 volume result of a Thy-1 GFP mice brain. (b) (c) (d) Images from different depth of the brain tissue. Note that the depth labels are only used to mark location as the surface imaging strategy is adopted. Left ones are 20 μm z-stack projections cropped from different depth imaging planes. The depth represents the distance from the original surface of this sample. The inserts show zoom-in views of green solid line boxes. Images on the right are xy sections and xz sections of the red dash line boxes. Curve diagrams profile the intensity alone the lines in relevant images. Arrows point to the same fiber in each depth respectively. Scale bars: left ones, 100 μm, inserts and right ones, 10 μm.

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