Abstract

Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model of the cornea. Included is an efficient method of measuring high temporal resolution (1 minute demonstrated) corneal thickness, using automated collection and semi-automated graph search segmentation. These methods expand OCT capabilities to measure volume change processes for tissues and materials.

Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

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References

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2017 (2)

V. Romano, B. Steger, J. Myneni, M. Batterbury, C. E. Willoughby, and S. B. Kaye, “Preparation of ultrathin grafts for Descemet-stripping endothelial keratoplasty with a single microkeratome pass,” J. Cataract Refract. Surg. 43(1), 12–15 (2017).
[PubMed]

K. V. Larin and D. D. Sampson, “Optical coherence elastography - OCT at work in tissue biomechanics [Invited],” Biomed. Opt. Express 8(2), 1172–1202 (2017).
[PubMed]

2016 (8)

S. Lawman, Y. Dong, B. M. Williams, V. Romano, S. Kaye, S. P. Harding, C. Willoughby, Y. C. Shen, and Y. Zheng, “High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography,” Opt. Express 24(11), 12395–12405 (2016).
[PubMed]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[PubMed]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[PubMed]

M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
[PubMed]

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

P. Gain, R. Jullienne, Z. He, M. Aldossary, S. Acquart, F. Cognasse, and G. Thuret, “Global Survey of Corneal Transplantation and Eye Banking,” JAMA Ophthalmol. 134(2), 167–173 (2016).
[PubMed]

K. Wacker, J. W. McLaren, K. M. Kane, K. H. Baratz, and S. V. Patel, “Corneal Hydration Control in Fuchs’ Endothelial Corneal Dystrophy,” Invest. Ophthalmol. Vis. Sci. 57(11), 5060–5065 (2016).
[PubMed]

E. Nielsen, A. Ivarsen, M. Erlandsen, and J. Hjortdal, “Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty,” Cornea 35(6), 878–883 (2016).
[PubMed]

2015 (6)

J. T. Lie, C. Monnereau, E. A. Groeneveld-van Beek, J. van der Wees, J. Frank, M. Bruinsma, and G. R. J. Melles, “Dehydration of corneal anterior donor tissue with polyethylene glycol (PEG)-enriched media,” Cell Tissue Bank. 16(3), 399–409 (2015).
[PubMed]

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

D. Williams, Y. Zheng, F. Bao, and A. Elsheikh, “Fast segmentation of anterior segment optical coherence tomography images using graph cut,” Eye Vis (Lond) 2, 1 (2015).
[PubMed]

P. Tankam, Z. He, Y. J. Chu, J. Won, C. Canavesi, T. Lepine, H. B. Hindman, D. J. Topham, P. Gain, G. Thuret, and J. P. Rolland, “Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases,” Opt. Lett. 40(6), 1113–1116 (2015).
[PubMed]

Y. Zhang, B. Dong, Y. Bai, S. Ye, Z. Lei, and Y. Zhou, “Measurement of depth-resolved thermal deformation distribution using phase-contrast spectral optical coherence tomography,” Opt. Express 23(21), 28067–28075 (2015).
[PubMed]

2014 (4)

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[PubMed]

S. Wang and K. V. Larin, “Noncontact depth-resolved micro-scale optical coherence elastography of the cornea,” Biomed. Opt. Express 5(11), 3807–3821 (2014).
[PubMed]

D. H. Cortes, N. T. Jacobs, J. F. DeLucca, and D. M. Elliott, “Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering,” J. Biomech. 47(9), 2088–2094 (2014).
[PubMed]

R. A. Leitgeb, R. M. Werkmeister, C. Blatter, and L. Schmetterer, “Doppler Optical Coherence Tomography,” Prog. Retin. Eye Res. 41, 26–43 (2014).
[PubMed]

2013 (3)

M. R. Bald, C. Stoeger, J. Galloway, M. Tang, J. Holiman, and D. Huang, “Use of fourier-domain optical coherence tomography to evaluate anterior stromal opacities in donor corneas,” J. Ophthalmol. 2013, 397680 (2013).
[PubMed]

F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
[PubMed]

M. Rossi, R. Mistò, C. Gatto, P. Garimoldi, M. Campanelli, and J. D’Amato Tóthová, “Protective Effects of Deswelling on Stromal Collagen Denaturation After a Corneal Femtosecond Laser Cut,” Invest. Ophthalmol. Vis. Sci. 54(6), 4148–4157 (2013).
[PubMed]

2012 (3)

V. A. Smith and T. K. Johnson, “Identification and evaluation of a thinning agent compatible with MegaCell DCS, an animal product-free corneal storage medium,” Graefes Arch. Clin. Exp. Ophthalmol. 250(12), 1777–1786 (2012).
[PubMed]

M. Lombardo, G. Lombardo, G. Carbone, M. P. De Santo, R. Barberi, and S. Serrao, “Biomechanics of the anterior human corneal tissue investigated with atomic force microscopy,” Invest. Ophthalmol. Vis. Sci. 53(2), 1050–1057 (2012).
[PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[PubMed]

2011 (3)

D. F. Larkin, L. L. Mumford, M. N. Jones, and NHS Blood and Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG Audit Study 7), “Centre-specific variation in corneal transplant outcomes in the United Kingdom,” Transplantation 91(3), 354–359 (2011).
[PubMed]

D. Amato, M. Lombardo, F. Oddone, M. Nubile, R. A. Colabelli Gisoldi, C. M. Villani, S. Yoo, J. M. Parel, and A. Pocobelli, “Evaluation of a new method for the measurement of corneal thickness in eye bank posterior corneal lenticules using anterior segment optical coherence tomography,” Br. J. Ophthalmol. 95(4), 580–584 (2011).
[PubMed]

Y. Wu, D. Clarke, A. Mathew, I. Nicoud, and X. Li, “Noninvasive optical coherence tomography monitoring of structure and hydration changes of human corneas in different preservation media,” J. Biomed. Opt. 16(2), 026015 (2011).
[PubMed]

2010 (1)

N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
[PubMed]

2009 (5)

C. Y. Choi, D. J. Youm, M. J. Kim, and H. Tchah, “Changes in Central Corneal Thickness of Preserved Corneas Over Time Measured Using Anterior Segment Optical Coherence Tomography,” Cornea 28(5), 536–540 (2009).
[PubMed]

C. Kelliher, C. Engler, C. Speck, D. Ward, S. Farazdaghi, and A. S. Jun, “A comprehensive analysis of eye bank-prepared posterior lamellar corneal tissue for use in endothelial keratoplasty,” Cornea 28(9), 966–970 (2009).
[PubMed]

A. H. Wolf, U. C. Welge-Lüssen, S. Priglinger, D. Kook, M. Grueterich, K. Hartmann, A. Kampik, and A. S. Neubauer, “Optimizing the Deswelling Process of Organ-Cultured Corneas,” Cornea 28(5), 524–529 (2009).
[PubMed]

E. Pels and W. J. Rijneveld, “Organ culture preservation for corneal tissue. Technical and quality aspects,” Dev. Ophthalmol. 43, 31–46 (2009).
[PubMed]

Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, “Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing,” Opt. Express 17(13), 10681–10687 (2009).
[PubMed]

2008 (1)

M. Zhao, G. Thuret, S. Piselli, A. Pipparelli, S. Acquart, M. Peoc’h, J. M. Dumollard, and P. Gain, “Use of poloxamers for deswelling of organ-cultured corneas,” Invest. Ophthalmol. Vis. Sci. 49(2), 550–559 (2008).
[PubMed]

2007 (1)

M. Akiba, N. Maeda, K. Yumikake, T. Soma, K. Nishida, Y. Tano, and K. P. Chan, “Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography,” J. Biomed. Opt. 12(4), 041202 (2007).
[PubMed]

2006 (2)

2004 (1)

L. Y. Li, B. J. Tighe, and J. W. Ruberti, “Mathematical modelling of corneal swelling,” Biomech. Model. Mechanobiol. 3(2), 114–123 (2004).
[PubMed]

2003 (1)

W. J. Armitage, A. D. Dick, and W. M. Bourne, “Predicting endothelial cell loss and long-term corneal graft survival,” Invest. Ophthalmol. Vis. Sci. 44(8), 3326–3331 (2003).
[PubMed]

2002 (2)

A. S. Neubauer, S. G. Priglinger, M. J. Thiel, C. A. May, and U. C. Welge-Lüssen, “Sterile structural imaging of donor cornea by optical coherence tomography,” Cornea 21(5), 490–494 (2002).
[PubMed]

S. K. De, N. R. Aluru, B. Johnson, W. C. Crone, D. J. Beebe, and J. Moore, “Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations,” J. Microelectromech. Syst. 11, 544–555 (2002).

2001 (1)

Y. Boykov, O. Veksler, and R. Zabih, “Fast approximate energy minimization via graph cuts,” IEEE Trans. Pattern Anal. Mach. Intell. 23, 1222–1239 (2001).

1999 (1)

1998 (1)

1997 (1)

C. Redbrake, S. Salla, R. Nilius, J. Becker, and M. Reim, “A histochemical study of the distribution of dextran 500 in human corneas during organ culture,” Curr. Eye Res. 16(5), 405–411 (1997).
[PubMed]

1995 (1)

R. Nilius, C. Redbrake, S. Salla, and M. Reim, “Influence of preparation and storage on human corneal thickness,” Vision Res. 35, 173 (1995).

1993 (1)

N. R. Pal and S. K. Pal, “A review on image segmentation techniques,” Pattern Recognit. 26, 1277–1294 (1993).

1985 (1)

E. Pels and Y. Schuchard, “The effects of high molecular weight dextran on the preservation of human corneas,” Cornea 3(3), 219–227 (1985).
[PubMed]

1972 (1)

M. H. Friedman, “A Quantitative Description of Equilibrium and Homeostatic Thickness Regulation in the In Vivo Cornea. I. Normal Cornea,” Biophys. J. 12(6), 648–665 (1972).
[PubMed]

1966 (2)

F. W. Stocker, E. H. King, D. O. Lucas, and N. Georgiade, “A comparison of two different staining methods for evaluating corneal endothelial viability,” Arch. Ophthalmol. 76(6), 833–835 (1966).
[PubMed]

B. O. Hedbys and S. Mishima, “The thickness-hydration relationship of the cornea,” Exp. Eye Res. 5(3), 221–228 (1966).
[PubMed]

1965 (1)

I. Fatt and T. K. Goldstick, “Dynamics of water transport in swelling membranes,” J. Colloid Sci. 20(9), 962–989 (1965).
[PubMed]

Acquart, S.

P. Gain, R. Jullienne, Z. He, M. Aldossary, S. Acquart, F. Cognasse, and G. Thuret, “Global Survey of Corneal Transplantation and Eye Banking,” JAMA Ophthalmol. 134(2), 167–173 (2016).
[PubMed]

M. Zhao, G. Thuret, S. Piselli, A. Pipparelli, S. Acquart, M. Peoc’h, J. M. Dumollard, and P. Gain, “Use of poloxamers for deswelling of organ-cultured corneas,” Invest. Ophthalmol. Vis. Sci. 49(2), 550–559 (2008).
[PubMed]

Ahmad, S.

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

Akiba, M.

M. Akiba, N. Maeda, K. Yumikake, T. Soma, K. Nishida, Y. Tano, and K. P. Chan, “Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography,” J. Biomed. Opt. 12(4), 041202 (2007).
[PubMed]

Aldossary, M.

P. Gain, R. Jullienne, Z. He, M. Aldossary, S. Acquart, F. Cognasse, and G. Thuret, “Global Survey of Corneal Transplantation and Eye Banking,” JAMA Ophthalmol. 134(2), 167–173 (2016).
[PubMed]

Aluru, N. R.

S. K. De, N. R. Aluru, B. Johnson, W. C. Crone, D. J. Beebe, and J. Moore, “Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations,” J. Microelectromech. Syst. 11, 544–555 (2002).

Amato, D.

D. Amato, M. Lombardo, F. Oddone, M. Nubile, R. A. Colabelli Gisoldi, C. M. Villani, S. Yoo, J. M. Parel, and A. Pocobelli, “Evaluation of a new method for the measurement of corneal thickness in eye bank posterior corneal lenticules using anterior segment optical coherence tomography,” Br. J. Ophthalmol. 95(4), 580–584 (2011).
[PubMed]

Ang, M.

M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
[PubMed]

Armitage, W. J.

W. J. Armitage, A. D. Dick, and W. M. Bourne, “Predicting endothelial cell loss and long-term corneal graft survival,” Invest. Ophthalmol. Vis. Sci. 44(8), 3326–3331 (2003).
[PubMed]

Badizadegan, K.

Bai, Y.

Bald, M. R.

M. R. Bald, C. Stoeger, J. Galloway, M. Tang, J. Holiman, and D. Huang, “Use of fourier-domain optical coherence tomography to evaluate anterior stromal opacities in donor corneas,” J. Ophthalmol. 2013, 397680 (2013).
[PubMed]

Bao, F.

D. Williams, Y. Zheng, F. Bao, and A. Elsheikh, “Fast segmentation of anterior segment optical coherence tomography images using graph cut,” Eye Vis (Lond) 2, 1 (2015).
[PubMed]

Baratz, K. H.

K. Wacker, J. W. McLaren, K. M. Kane, K. H. Baratz, and S. V. Patel, “Corneal Hydration Control in Fuchs’ Endothelial Corneal Dystrophy,” Invest. Ophthalmol. Vis. Sci. 57(11), 5060–5065 (2016).
[PubMed]

Barberi, R.

M. Lombardo, G. Lombardo, G. Carbone, M. P. De Santo, R. Barberi, and S. Serrao, “Biomechanics of the anterior human corneal tissue investigated with atomic force microscopy,” Invest. Ophthalmol. Vis. Sci. 53(2), 1050–1057 (2012).
[PubMed]

Batterbury, M.

V. Romano, B. Steger, J. Myneni, M. Batterbury, C. E. Willoughby, and S. B. Kaye, “Preparation of ultrathin grafts for Descemet-stripping endothelial keratoplasty with a single microkeratome pass,” J. Cataract Refract. Surg. 43(1), 12–15 (2017).
[PubMed]

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

Baumann, B.

R. Haindl, W. Trasischker, A. Wartak, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Total retinal blood flow and reproducibility evaluation by three beam optical Doppler tomography,” in 26th Conference on Ophthalmic Technologies, Proceedings of SPIE 2016)

Becker, J.

C. Redbrake, S. Salla, R. Nilius, J. Becker, and M. Reim, “A histochemical study of the distribution of dextran 500 in human corneas during organ culture,” Curr. Eye Res. 16(5), 405–411 (1997).
[PubMed]

Beebe, D. J.

S. K. De, N. R. Aluru, B. Johnson, W. C. Crone, D. J. Beebe, and J. Moore, “Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations,” J. Microelectromech. Syst. 11, 544–555 (2002).

Bizheva, K.

N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
[PubMed]

Blatter, C.

R. A. Leitgeb, R. M. Werkmeister, C. Blatter, and L. Schmetterer, “Doppler Optical Coherence Tomography,” Prog. Retin. Eye Res. 41, 26–43 (2014).
[PubMed]

Bourne, W. M.

W. J. Armitage, A. D. Dick, and W. M. Bourne, “Predicting endothelial cell loss and long-term corneal graft survival,” Invest. Ophthalmol. Vis. Sci. 44(8), 3326–3331 (2003).
[PubMed]

Bovone, C.

A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

Boykov, Y.

Y. Boykov, O. Veksler, and R. Zabih, “Fast approximate energy minimization via graph cuts,” IEEE Trans. Pattern Anal. Mach. Intell. 23, 1222–1239 (2001).

Bruinsma, M.

J. T. Lie, C. Monnereau, E. A. Groeneveld-van Beek, J. van der Wees, J. Frank, M. Bruinsma, and G. R. J. Melles, “Dehydration of corneal anterior donor tissue with polyethylene glycol (PEG)-enriched media,” Cell Tissue Bank. 16(3), 399–409 (2015).
[PubMed]

Bucher, F.

F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
[PubMed]

Busin, M.

A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

Campanelli, M.

M. Rossi, R. Mistò, C. Gatto, P. Garimoldi, M. Campanelli, and J. D’Amato Tóthová, “Protective Effects of Deswelling on Stromal Collagen Denaturation After a Corneal Femtosecond Laser Cut,” Invest. Ophthalmol. Vis. Sci. 54(6), 4148–4157 (2013).
[PubMed]

Canavesi, C.

Carbone, G.

M. Lombardo, G. Lombardo, G. Carbone, M. P. De Santo, R. Barberi, and S. Serrao, “Biomechanics of the anterior human corneal tissue investigated with atomic force microscopy,” Invest. Ophthalmol. Vis. Sci. 53(2), 1050–1057 (2012).
[PubMed]

Chan, K. P.

M. Akiba, N. Maeda, K. Yumikake, T. Soma, K. Nishida, Y. Tano, and K. P. Chan, “Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography,” J. Biomed. Opt. 12(4), 041202 (2007).
[PubMed]

Chen, J. Y.

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

Chen, S.

M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
[PubMed]

Chin, L.

Choi, C. Y.

C. Y. Choi, D. J. Youm, M. J. Kim, and H. Tchah, “Changes in Central Corneal Thickness of Preserved Corneas Over Time Measured Using Anterior Segment Optical Coherence Tomography,” Cornea 28(5), 536–540 (2009).
[PubMed]

Choi, W.

Chu, Y. J.

Clarke, D.

Y. Wu, D. Clarke, A. Mathew, I. Nicoud, and X. Li, “Noninvasive optical coherence tomography monitoring of structure and hydration changes of human corneas in different preservation media,” J. Biomed. Opt. 16(2), 026015 (2011).
[PubMed]

Cognasse, F.

P. Gain, R. Jullienne, Z. He, M. Aldossary, S. Acquart, F. Cognasse, and G. Thuret, “Global Survey of Corneal Transplantation and Eye Banking,” JAMA Ophthalmol. 134(2), 167–173 (2016).
[PubMed]

Colabelli Gisoldi, R. A.

D. Amato, M. Lombardo, F. Oddone, M. Nubile, R. A. Colabelli Gisoldi, C. M. Villani, S. Yoo, J. M. Parel, and A. Pocobelli, “Evaluation of a new method for the measurement of corneal thickness in eye bank posterior corneal lenticules using anterior segment optical coherence tomography,” Br. J. Ophthalmol. 95(4), 580–584 (2011).
[PubMed]

Cortes, D. H.

D. H. Cortes, N. T. Jacobs, J. F. DeLucca, and D. M. Elliott, “Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering,” J. Biomech. 47(9), 2088–2094 (2014).
[PubMed]

Coster, D. J.

K. A. Williams, M. C. Keane, R. A. Galettis, V. J. Jones, R. A. Mills, and D. J. Coster, “The Australian Corneal Graft Registry 2015 Report,” (2015).

Crone, W. C.

S. K. De, N. R. Aluru, B. Johnson, W. C. Crone, D. J. Beebe, and J. Moore, “Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations,” J. Microelectromech. Syst. 11, 544–555 (2002).

Curatolo, A.

Cursiefen, C.

F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
[PubMed]

D’Amato Tóthová, J.

M. Rossi, R. Mistò, C. Gatto, P. Garimoldi, M. Campanelli, and J. D’Amato Tóthová, “Protective Effects of Deswelling on Stromal Collagen Denaturation After a Corneal Femtosecond Laser Cut,” Invest. Ophthalmol. Vis. Sci. 54(6), 4148–4157 (2013).
[PubMed]

Dasari, R. R.

De, S. K.

S. K. De, N. R. Aluru, B. Johnson, W. C. Crone, D. J. Beebe, and J. Moore, “Equilibrium swelling and kinetics of pH-responsive hydrogels: Models, experiments, and simulations,” J. Microelectromech. Syst. 11, 544–555 (2002).

De la Torre-Ibarra, M. H.

De Santo, M. P.

M. Lombardo, G. Lombardo, G. Carbone, M. P. De Santo, R. Barberi, and S. Serrao, “Biomechanics of the anterior human corneal tissue investigated with atomic force microscopy,” Invest. Ophthalmol. Vis. Sci. 53(2), 1050–1057 (2012).
[PubMed]

DeLucca, J. F.

D. H. Cortes, N. T. Jacobs, J. F. DeLucca, and D. M. Elliott, “Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering,” J. Biomech. 47(9), 2088–2094 (2014).
[PubMed]

Dick, A. D.

W. J. Armitage, A. D. Dick, and W. M. Bourne, “Predicting endothelial cell loss and long-term corneal graft survival,” Invest. Ophthalmol. Vis. Sci. 44(8), 3326–3331 (2003).
[PubMed]

Dong, B.

Dong, Y.

Dumollard, J. M.

M. Zhao, G. Thuret, S. Piselli, A. Pipparelli, S. Acquart, M. Peoc’h, J. M. Dumollard, and P. Gain, “Use of poloxamers for deswelling of organ-cultured corneas,” Invest. Ophthalmol. Vis. Sci. 49(2), 550–559 (2008).
[PubMed]

Elliott, D. M.

D. H. Cortes, N. T. Jacobs, J. F. DeLucca, and D. M. Elliott, “Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering,” J. Biomech. 47(9), 2088–2094 (2014).
[PubMed]

Elsheikh, A.

D. Williams, Y. Zheng, F. Bao, and A. Elsheikh, “Fast segmentation of anterior segment optical coherence tomography images using graph cut,” Eye Vis (Lond) 2, 1 (2015).
[PubMed]

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

Engler, C.

C. Kelliher, C. Engler, C. Speck, D. Ward, S. Farazdaghi, and A. S. Jun, “A comprehensive analysis of eye bank-prepared posterior lamellar corneal tissue for use in endothelial keratoplasty,” Cornea 28(9), 966–970 (2009).
[PubMed]

Erlandsen, M.

E. Nielsen, A. Ivarsen, M. Erlandsen, and J. Hjortdal, “Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty,” Cornea 35(6), 878–883 (2016).
[PubMed]

Fang-Yen, C.

Farazdaghi, S.

C. Kelliher, C. Engler, C. Speck, D. Ward, S. Farazdaghi, and A. S. Jun, “A comprehensive analysis of eye bank-prepared posterior lamellar corneal tissue for use in endothelial keratoplasty,” Cornea 28(9), 966–970 (2009).
[PubMed]

Fatt, I.

I. Fatt and T. K. Goldstick, “Dynamics of water transport in swelling membranes,” J. Colloid Sci. 20(9), 962–989 (1965).
[PubMed]

Feld, M. S.

Ferrari, S.

A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

Flammersfeld, A.

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

Frank, J.

J. T. Lie, C. Monnereau, E. A. Groeneveld-van Beek, J. van der Wees, J. Frank, M. Bruinsma, and G. R. J. Melles, “Dehydration of corneal anterior donor tissue with polyethylene glycol (PEG)-enriched media,” Cell Tissue Bank. 16(3), 399–409 (2015).
[PubMed]

Friedman, M. H.

M. H. Friedman, “A Quantitative Description of Equilibrium and Homeostatic Thickness Regulation in the In Vivo Cornea. I. Normal Cornea,” Biophys. J. 12(6), 648–665 (1972).
[PubMed]

Fuest, M.

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

Gain, P.

P. Gain, R. Jullienne, Z. He, M. Aldossary, S. Acquart, F. Cognasse, and G. Thuret, “Global Survey of Corneal Transplantation and Eye Banking,” JAMA Ophthalmol. 134(2), 167–173 (2016).
[PubMed]

P. Tankam, Z. He, Y. J. Chu, J. Won, C. Canavesi, T. Lepine, H. B. Hindman, D. J. Topham, P. Gain, G. Thuret, and J. P. Rolland, “Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases,” Opt. Lett. 40(6), 1113–1116 (2015).
[PubMed]

M. Zhao, G. Thuret, S. Piselli, A. Pipparelli, S. Acquart, M. Peoc’h, J. M. Dumollard, and P. Gain, “Use of poloxamers for deswelling of organ-cultured corneas,” Invest. Ophthalmol. Vis. Sci. 49(2), 550–559 (2008).
[PubMed]

Galettis, R. A.

K. A. Williams, M. C. Keane, R. A. Galettis, V. J. Jones, R. A. Mills, and D. J. Coster, “The Australian Corneal Graft Registry 2015 Report,” (2015).

Galloway, J.

M. R. Bald, C. Stoeger, J. Galloway, M. Tang, J. Holiman, and D. Huang, “Use of fourier-domain optical coherence tomography to evaluate anterior stromal opacities in donor corneas,” J. Ophthalmol. 2013, 397680 (2013).
[PubMed]

Garimoldi, P.

M. Rossi, R. Mistò, C. Gatto, P. Garimoldi, M. Campanelli, and J. D’Amato Tóthová, “Protective Effects of Deswelling on Stromal Collagen Denaturation After a Corneal Femtosecond Laser Cut,” Invest. Ophthalmol. Vis. Sci. 54(6), 4148–4157 (2013).
[PubMed]

Gatto, C.

M. Rossi, R. Mistò, C. Gatto, P. Garimoldi, M. Campanelli, and J. D’Amato Tóthová, “Protective Effects of Deswelling on Stromal Collagen Denaturation After a Corneal Femtosecond Laser Cut,” Invest. Ophthalmol. Vis. Sci. 54(6), 4148–4157 (2013).
[PubMed]

Gelikonov, G. V.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[PubMed]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[PubMed]

Georgiade, N.

F. W. Stocker, E. H. King, D. O. Lucas, and N. Georgiade, “A comparison of two different staining methods for evaluating corneal endothelial viability,” Arch. Ophthalmol. 76(6), 833–835 (1966).
[PubMed]

Gladkova, N. D.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[PubMed]

Goh, G.

M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
[PubMed]

Goldstick, T. K.

I. Fatt and T. K. Goldstick, “Dynamics of water transport in swelling membranes,” J. Colloid Sci. 20(9), 962–989 (1965).
[PubMed]

Groeneveld-van Beek, E. A.

J. T. Lie, C. Monnereau, E. A. Groeneveld-van Beek, J. van der Wees, J. Frank, M. Bruinsma, and G. R. J. Melles, “Dehydration of corneal anterior donor tissue with polyethylene glycol (PEG)-enriched media,” Cell Tissue Bank. 16(3), 399–409 (2015).
[PubMed]

Grueterich, M.

A. H. Wolf, U. C. Welge-Lüssen, S. Priglinger, D. Kook, M. Grueterich, K. Hartmann, A. Kampik, and A. S. Neubauer, “Optimizing the Deswelling Process of Organ-Cultured Corneas,” Cornea 28(5), 524–529 (2009).
[PubMed]

Gubarkova, E. V.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[PubMed]

Haindl, R.

R. Haindl, W. Trasischker, A. Wartak, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Total retinal blood flow and reproducibility evaluation by three beam optical Doppler tomography,” in 26th Conference on Ophthalmic Technologies, Proceedings of SPIE 2016)

Hamsley, N.

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

Harding, S. P.

Hariri, S.

N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
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A. H. Wolf, U. C. Welge-Lüssen, S. Priglinger, D. Kook, M. Grueterich, K. Hartmann, A. Kampik, and A. S. Neubauer, “Optimizing the Deswelling Process of Organ-Cultured Corneas,” Cornea 28(5), 524–529 (2009).
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V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
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B. O. Hedbys and S. Mishima, “The thickness-hydration relationship of the cornea,” Exp. Eye Res. 5(3), 221–228 (1966).
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F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
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F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
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Hjortdal, J.

E. Nielsen, A. Ivarsen, M. Erlandsen, and J. Hjortdal, “Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty,” Cornea 35(6), 878–883 (2016).
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M. R. Bald, C. Stoeger, J. Galloway, M. Tang, J. Holiman, and D. Huang, “Use of fourier-domain optical coherence tomography to evaluate anterior stromal opacities in donor corneas,” J. Ophthalmol. 2013, 397680 (2013).
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F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
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M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
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N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
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E. Nielsen, A. Ivarsen, M. Erlandsen, and J. Hjortdal, “Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty,” Cornea 35(6), 878–883 (2016).
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V. A. Smith and T. K. Johnson, “Identification and evaluation of a thinning agent compatible with MegaCell DCS, an animal product-free corneal storage medium,” Graefes Arch. Clin. Exp. Ophthalmol. 250(12), 1777–1786 (2012).
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D. F. Larkin, L. L. Mumford, M. N. Jones, and NHS Blood and Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG Audit Study 7), “Centre-specific variation in corneal transplant outcomes in the United Kingdom,” Transplantation 91(3), 354–359 (2011).
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K. Wacker, J. W. McLaren, K. M. Kane, K. H. Baratz, and S. V. Patel, “Corneal Hydration Control in Fuchs’ Endothelial Corneal Dystrophy,” Invest. Ophthalmol. Vis. Sci. 57(11), 5060–5065 (2016).
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Kaye, S. B.

V. Romano, B. Steger, J. Myneni, M. Batterbury, C. E. Willoughby, and S. B. Kaye, “Preparation of ultrathin grafts for Descemet-stripping endothelial keratoplasty with a single microkeratome pass,” J. Cataract Refract. Surg. 43(1), 12–15 (2017).
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C. Kelliher, C. Engler, C. Speck, D. Ward, S. Farazdaghi, and A. S. Jun, “A comprehensive analysis of eye bank-prepared posterior lamellar corneal tissue for use in endothelial keratoplasty,” Cornea 28(9), 966–970 (2009).
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M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
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F. W. Stocker, E. H. King, D. O. Lucas, and N. Georgiade, “A comparison of two different staining methods for evaluating corneal endothelial viability,” Arch. Ophthalmol. 76(6), 833–835 (1966).
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Y. Wu, D. Clarke, A. Mathew, I. Nicoud, and X. Li, “Noninvasive optical coherence tomography monitoring of structure and hydration changes of human corneas in different preservation media,” J. Biomed. Opt. 16(2), 026015 (2011).
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A. S. Neubauer, S. G. Priglinger, M. J. Thiel, C. A. May, and U. C. Welge-Lüssen, “Sterile structural imaging of donor cornea by optical coherence tomography,” Cornea 21(5), 490–494 (2002).
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K. Wacker, J. W. McLaren, K. M. Kane, K. H. Baratz, and S. V. Patel, “Corneal Hydration Control in Fuchs’ Endothelial Corneal Dystrophy,” Invest. Ophthalmol. Vis. Sci. 57(11), 5060–5065 (2016).
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Mehta, J. S.

M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
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J. T. Lie, C. Monnereau, E. A. Groeneveld-van Beek, J. van der Wees, J. Frank, M. Bruinsma, and G. R. J. Melles, “Dehydration of corneal anterior donor tissue with polyethylene glycol (PEG)-enriched media,” Cell Tissue Bank. 16(3), 399–409 (2015).
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B. O. Hedbys and S. Mishima, “The thickness-hydration relationship of the cornea,” Exp. Eye Res. 5(3), 221–228 (1966).
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N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
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Mumford, L. L.

D. F. Larkin, L. L. Mumford, M. N. Jones, and NHS Blood and Transplant Ocular Tissue Advisory Group and Contributing Ophthalmologists (OTAG Audit Study 7), “Centre-specific variation in corneal transplant outcomes in the United Kingdom,” Transplantation 91(3), 354–359 (2011).
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Myneni, J.

V. Romano, B. Steger, J. Myneni, M. Batterbury, C. E. Willoughby, and S. B. Kaye, “Preparation of ultrathin grafts for Descemet-stripping endothelial keratoplasty with a single microkeratome pass,” J. Cataract Refract. Surg. 43(1), 12–15 (2017).
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Y. Wu, D. Clarke, A. Mathew, I. Nicoud, and X. Li, “Noninvasive optical coherence tomography monitoring of structure and hydration changes of human corneas in different preservation media,” J. Biomed. Opt. 16(2), 026015 (2011).
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D. Amato, M. Lombardo, F. Oddone, M. Nubile, R. A. Colabelli Gisoldi, C. M. Villani, S. Yoo, J. M. Parel, and A. Pocobelli, “Evaluation of a new method for the measurement of corneal thickness in eye bank posterior corneal lenticules using anterior segment optical coherence tomography,” Br. J. Ophthalmol. 95(4), 580–584 (2011).
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Piselli, S.

M. Zhao, G. Thuret, S. Piselli, A. Pipparelli, S. Acquart, M. Peoc’h, J. M. Dumollard, and P. Gain, “Use of poloxamers for deswelling of organ-cultured corneas,” Invest. Ophthalmol. Vis. Sci. 49(2), 550–559 (2008).
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A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

Priglinger, S.

A. H. Wolf, U. C. Welge-Lüssen, S. Priglinger, D. Kook, M. Grueterich, K. Hartmann, A. Kampik, and A. S. Neubauer, “Optimizing the Deswelling Process of Organ-Cultured Corneas,” Cornea 28(5), 524–529 (2009).
[PubMed]

Priglinger, S. G.

A. S. Neubauer, S. G. Priglinger, M. J. Thiel, C. A. May, and U. C. Welge-Lüssen, “Sterile structural imaging of donor cornea by optical coherence tomography,” Cornea 21(5), 490–494 (2002).
[PubMed]

Redbrake, C.

C. Redbrake, S. Salla, R. Nilius, J. Becker, and M. Reim, “A histochemical study of the distribution of dextran 500 in human corneas during organ culture,” Curr. Eye Res. 16(5), 405–411 (1997).
[PubMed]

R. Nilius, C. Redbrake, S. Salla, and M. Reim, “Influence of preparation and storage on human corneal thickness,” Vision Res. 35, 173 (1995).

Reim, M.

C. Redbrake, S. Salla, R. Nilius, J. Becker, and M. Reim, “A histochemical study of the distribution of dextran 500 in human corneas during organ culture,” Curr. Eye Res. 16(5), 405–411 (1997).
[PubMed]

R. Nilius, C. Redbrake, S. Salla, and M. Reim, “Influence of preparation and storage on human corneal thickness,” Vision Res. 35, 173 (1995).

Richards-Kortum, R.

Rijneveld, W. J.

E. Pels and W. J. Rijneveld, “Organ culture preservation for corneal tissue. Technical and quality aspects,” Dev. Ophthalmol. 43, 31–46 (2009).
[PubMed]

Rolland, J. P.

Romano, V.

V. Romano, B. Steger, J. Myneni, M. Batterbury, C. E. Willoughby, and S. B. Kaye, “Preparation of ultrathin grafts for Descemet-stripping endothelial keratoplasty with a single microkeratome pass,” J. Cataract Refract. Surg. 43(1), 12–15 (2017).
[PubMed]

S. Lawman, Y. Dong, B. M. Williams, V. Romano, S. Kaye, S. P. Harding, C. Willoughby, Y. C. Shen, and Y. Zheng, “High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography,” Opt. Express 24(11), 12395–12405 (2016).
[PubMed]

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

Rossi, M.

M. Rossi, R. Mistò, C. Gatto, P. Garimoldi, M. Campanelli, and J. D’Amato Tóthová, “Protective Effects of Deswelling on Stromal Collagen Denaturation After a Corneal Femtosecond Laser Cut,” Invest. Ophthalmol. Vis. Sci. 54(6), 4148–4157 (2013).
[PubMed]

Roters, S.

F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
[PubMed]

Ruberti, J. W.

L. Y. Li, B. J. Tighe, and J. W. Ruberti, “Mathematical modelling of corneal swelling,” Biomech. Model. Mechanobiol. 3(2), 114–123 (2004).
[PubMed]

Ruiz, P. D.

Ruzza, A.

A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

Salla, S.

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

C. Redbrake, S. Salla, R. Nilius, J. Becker, and M. Reim, “A histochemical study of the distribution of dextran 500 in human corneas during organ culture,” Curr. Eye Res. 16(5), 405–411 (1997).
[PubMed]

R. Nilius, C. Redbrake, S. Salla, and M. Reim, “Influence of preparation and storage on human corneal thickness,” Vision Res. 35, 173 (1995).

Salvalaio, G.

A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

Sampson, D. D.

Saunders, C. M.

Schmetterer, L.

R. A. Leitgeb, R. M. Werkmeister, C. Blatter, and L. Schmetterer, “Doppler Optical Coherence Tomography,” Prog. Retin. Eye Res. 41, 26–43 (2014).
[PubMed]

Schmitt, J.

Schnitzler, A. C.

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

Schuchard, Y.

E. Pels and Y. Schuchard, “The effects of high molecular weight dextran on the preservation of human corneas,” Cornea 3(3), 219–227 (1985).
[PubMed]

Seah, X.

M. Ang, A. Konstantopoulos, G. Goh, H. M. Htoon, X. Seah, N. C. Lwin, X. Liu, S. Chen, L. Liu, and J. S. Mehta, “Evaluation of a micro-optical coherence tomography for the corneal endothelium in an animal model,” Sci. Rep. 6, 29769 (2016).
[PubMed]

Serrao, S.

M. Lombardo, G. Lombardo, G. Carbone, M. P. De Santo, R. Barberi, and S. Serrao, “Biomechanics of the anterior human corneal tissue investigated with atomic force microscopy,” Invest. Ophthalmol. Vis. Sci. 53(2), 1050–1057 (2012).
[PubMed]

Shen, Y. C.

Simpson, T. L.

N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
[PubMed]

Smith, V. A.

V. A. Smith and T. K. Johnson, “Identification and evaluation of a thinning agent compatible with MegaCell DCS, an animal product-free corneal storage medium,” Graefes Arch. Clin. Exp. Ophthalmol. 250(12), 1777–1786 (2012).
[PubMed]

Soma, T.

M. Akiba, N. Maeda, K. Yumikake, T. Soma, K. Nishida, Y. Tano, and K. P. Chan, “Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography,” J. Biomed. Opt. 12(4), 041202 (2007).
[PubMed]

Sorbara, L.

N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
[PubMed]

Sovetsky, A. A.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[PubMed]

Speck, C.

C. Kelliher, C. Engler, C. Speck, D. Ward, S. Farazdaghi, and A. S. Jun, “A comprehensive analysis of eye bank-prepared posterior lamellar corneal tissue for use in endothelial keratoplasty,” Cornea 28(9), 966–970 (2009).
[PubMed]

Steger, B.

V. Romano, B. Steger, J. Myneni, M. Batterbury, C. E. Willoughby, and S. B. Kaye, “Preparation of ultrathin grafts for Descemet-stripping endothelial keratoplasty with a single microkeratome pass,” J. Cataract Refract. Surg. 43(1), 12–15 (2017).
[PubMed]

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

Stocker, F. W.

F. W. Stocker, E. H. King, D. O. Lucas, and N. Georgiade, “A comparison of two different staining methods for evaluating corneal endothelial viability,” Arch. Ophthalmol. 76(6), 833–835 (1966).
[PubMed]

Stoeger, C.

M. R. Bald, C. Stoeger, J. Galloway, M. Tang, J. Holiman, and D. Huang, “Use of fourier-domain optical coherence tomography to evaluate anterior stromal opacities in donor corneas,” J. Ophthalmol. 2013, 397680 (2013).
[PubMed]

Tang, M.

M. R. Bald, C. Stoeger, J. Galloway, M. Tang, J. Holiman, and D. Huang, “Use of fourier-domain optical coherence tomography to evaluate anterior stromal opacities in donor corneas,” J. Ophthalmol. 2013, 397680 (2013).
[PubMed]

Tankam, P.

Tano, Y.

M. Akiba, N. Maeda, K. Yumikake, T. Soma, K. Nishida, Y. Tano, and K. P. Chan, “Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography,” J. Biomed. Opt. 12(4), 041202 (2007).
[PubMed]

Tchah, H.

C. Y. Choi, D. J. Youm, M. J. Kim, and H. Tchah, “Changes in Central Corneal Thickness of Preserved Corneas Over Time Measured Using Anterior Segment Optical Coherence Tomography,” Cornea 28(5), 536–540 (2009).
[PubMed]

Thiel, M. J.

A. S. Neubauer, S. G. Priglinger, M. J. Thiel, C. A. May, and U. C. Welge-Lüssen, “Sterile structural imaging of donor cornea by optical coherence tomography,” Cornea 21(5), 490–494 (2002).
[PubMed]

Thuret, G.

P. Gain, R. Jullienne, Z. He, M. Aldossary, S. Acquart, F. Cognasse, and G. Thuret, “Global Survey of Corneal Transplantation and Eye Banking,” JAMA Ophthalmol. 134(2), 167–173 (2016).
[PubMed]

P. Tankam, Z. He, Y. J. Chu, J. Won, C. Canavesi, T. Lepine, H. B. Hindman, D. J. Topham, P. Gain, G. Thuret, and J. P. Rolland, “Assessing microstructures of the cornea with Gabor-domain optical coherence microscopy: pathway for corneal physiology and diseases,” Opt. Lett. 40(6), 1113–1116 (2015).
[PubMed]

M. Zhao, G. Thuret, S. Piselli, A. Pipparelli, S. Acquart, M. Peoc’h, J. M. Dumollard, and P. Gain, “Use of poloxamers for deswelling of organ-cultured corneas,” Invest. Ophthalmol. Vis. Sci. 49(2), 550–559 (2008).
[PubMed]

Tien, A.

Tighe, B. J.

L. Y. Li, B. J. Tighe, and J. W. Ruberti, “Mathematical modelling of corneal swelling,” Biomech. Model. Mechanobiol. 3(2), 114–123 (2004).
[PubMed]

Topham, D. J.

Trasischker, W.

R. Haindl, W. Trasischker, A. Wartak, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Total retinal blood flow and reproducibility evaluation by three beam optical Doppler tomography,” in 26th Conference on Ophthalmic Technologies, Proceedings of SPIE 2016)

van der Wees, J.

J. T. Lie, C. Monnereau, E. A. Groeneveld-van Beek, J. van der Wees, J. Frank, M. Bruinsma, and G. R. J. Melles, “Dehydration of corneal anterior donor tissue with polyethylene glycol (PEG)-enriched media,” Cell Tissue Bank. 16(3), 399–409 (2015).
[PubMed]

Veksler, O.

Y. Boykov, O. Veksler, and R. Zabih, “Fast approximate energy minimization via graph cuts,” IEEE Trans. Pattern Anal. Mach. Intell. 23, 1222–1239 (2001).

Villani, C. M.

D. Amato, M. Lombardo, F. Oddone, M. Nubile, R. A. Colabelli Gisoldi, C. M. Villani, S. Yoo, J. M. Parel, and A. Pocobelli, “Evaluation of a new method for the measurement of corneal thickness in eye bank posterior corneal lenticules using anterior segment optical coherence tomography,” Br. J. Ophthalmol. 95(4), 580–584 (2011).
[PubMed]

Vitkin, A.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[PubMed]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[PubMed]

Wacker, K.

K. Wacker, J. W. McLaren, K. M. Kane, K. H. Baratz, and S. V. Patel, “Corneal Hydration Control in Fuchs’ Endothelial Corneal Dystrophy,” Invest. Ophthalmol. Vis. Sci. 57(11), 5060–5065 (2016).
[PubMed]

Walter, P.

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

Wang, S.

Ward, D.

C. Kelliher, C. Engler, C. Speck, D. Ward, S. Farazdaghi, and A. S. Jun, “A comprehensive analysis of eye bank-prepared posterior lamellar corneal tissue for use in endothelial keratoplasty,” Cornea 28(9), 966–970 (2009).
[PubMed]

Wartak, A.

R. Haindl, W. Trasischker, A. Wartak, B. Baumann, M. Pircher, and C. K. Hitzenberger, “Total retinal blood flow and reproducibility evaluation by three beam optical Doppler tomography,” in 26th Conference on Ophthalmic Technologies, Proceedings of SPIE 2016)

Welge-Lüssen, U. C.

A. H. Wolf, U. C. Welge-Lüssen, S. Priglinger, D. Kook, M. Grueterich, K. Hartmann, A. Kampik, and A. S. Neubauer, “Optimizing the Deswelling Process of Organ-Cultured Corneas,” Cornea 28(5), 524–529 (2009).
[PubMed]

A. S. Neubauer, S. G. Priglinger, M. J. Thiel, C. A. May, and U. C. Welge-Lüssen, “Sterile structural imaging of donor cornea by optical coherence tomography,” Cornea 21(5), 490–494 (2002).
[PubMed]

Werkmeister, R. M.

R. A. Leitgeb, R. M. Werkmeister, C. Blatter, and L. Schmetterer, “Doppler Optical Coherence Tomography,” Prog. Retin. Eye Res. 41, 26–43 (2014).
[PubMed]

Williams, B. M.

Williams, D.

D. Williams, Y. Zheng, F. Bao, and A. Elsheikh, “Fast segmentation of anterior segment optical coherence tomography images using graph cut,” Eye Vis (Lond) 2, 1 (2015).
[PubMed]

Williams, K. A.

K. A. Williams, M. C. Keane, R. A. Galettis, V. J. Jones, R. A. Mills, and D. J. Coster, “The Australian Corneal Graft Registry 2015 Report,” (2015).

Willoughby, C.

Willoughby, C. E.

V. Romano, B. Steger, J. Myneni, M. Batterbury, C. E. Willoughby, and S. B. Kaye, “Preparation of ultrathin grafts for Descemet-stripping endothelial keratoplasty with a single microkeratome pass,” J. Cataract Refract. Surg. 43(1), 12–15 (2017).
[PubMed]

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

Wolf, A. H.

A. H. Wolf, U. C. Welge-Lüssen, S. Priglinger, D. Kook, M. Grueterich, K. Hartmann, A. Kampik, and A. S. Neubauer, “Optimizing the Deswelling Process of Organ-Cultured Corneas,” Cornea 28(5), 524–529 (2009).
[PubMed]

Won, J.

Wu, Y.

Y. Wu, D. Clarke, A. Mathew, I. Nicoud, and X. Li, “Noninvasive optical coherence tomography monitoring of structure and hydration changes of human corneas in different preservation media,” J. Biomed. Opt. 16(2), 026015 (2011).
[PubMed]

Yaqoob, Z.

Ye, S.

Yoo, S.

D. Amato, M. Lombardo, F. Oddone, M. Nubile, R. A. Colabelli Gisoldi, C. M. Villani, S. Yoo, J. M. Parel, and A. Pocobelli, “Evaluation of a new method for the measurement of corneal thickness in eye bank posterior corneal lenticules using anterior segment optical coherence tomography,” Br. J. Ophthalmol. 95(4), 580–584 (2011).
[PubMed]

Youm, D. J.

C. Y. Choi, D. J. Youm, M. J. Kim, and H. Tchah, “Changes in Central Corneal Thickness of Preserved Corneas Over Time Measured Using Anterior Segment Optical Coherence Tomography,” Cornea 28(5), 536–540 (2009).
[PubMed]

Yumikake, K.

M. Akiba, N. Maeda, K. Yumikake, T. Soma, K. Nishida, Y. Tano, and K. P. Chan, “Ultrahigh-resolution imaging of human donor cornea using full-field optical coherence tomography,” J. Biomed. Opt. 12(4), 041202 (2007).
[PubMed]

Zabih, R.

Y. Boykov, O. Veksler, and R. Zabih, “Fast approximate energy minimization via graph cuts,” IEEE Trans. Pattern Anal. Mach. Intell. 23, 1222–1239 (2001).

Zaitsev, V. Y.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, A. A. Sovetsky, and A. Vitkin, “Optimized phase gradient measurements and phase-amplitude interplay in optical coherence elastography,” J. Biomed. Opt. 21(11), 116005 (2016).
[PubMed]

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[PubMed]

Zhang, Y.

Zhao, M.

M. Zhao, G. Thuret, S. Piselli, A. Pipparelli, S. Acquart, M. Peoc’h, J. M. Dumollard, and P. Gain, “Use of poloxamers for deswelling of organ-cultured corneas,” Invest. Ophthalmol. Vis. Sci. 49(2), 550–559 (2008).
[PubMed]

Zheng, Y.

Zhou, Y.

Zuluaga, A. F.

Arch. Ophthalmol. (1)

F. W. Stocker, E. H. King, D. O. Lucas, and N. Georgiade, “A comparison of two different staining methods for evaluating corneal endothelial viability,” Arch. Ophthalmol. 76(6), 833–835 (1966).
[PubMed]

Biomech. Model. Mechanobiol. (1)

L. Y. Li, B. J. Tighe, and J. W. Ruberti, “Mathematical modelling of corneal swelling,” Biomech. Model. Mechanobiol. 3(2), 114–123 (2004).
[PubMed]

Biomed. Opt. Express (4)

Biophys. J. (1)

M. H. Friedman, “A Quantitative Description of Equilibrium and Homeostatic Thickness Regulation in the In Vivo Cornea. I. Normal Cornea,” Biophys. J. 12(6), 648–665 (1972).
[PubMed]

Br. J. Ophthalmol. (2)

D. Amato, M. Lombardo, F. Oddone, M. Nubile, R. A. Colabelli Gisoldi, C. M. Villani, S. Yoo, J. M. Parel, and A. Pocobelli, “Evaluation of a new method for the measurement of corneal thickness in eye bank posterior corneal lenticules using anterior segment optical coherence tomography,” Br. J. Ophthalmol. 95(4), 580–584 (2011).
[PubMed]

A. Ruzza, M. Parekh, S. Ferrari, G. Salvalaio, Y. Nahum, C. Bovone, D. Ponzin, and M. Busin, “Preloaded donor corneal lenticules in a new validated 3D printed smart storage glide for Descemet stripping automated endothelial keratoplasty,” Br. J. Ophthalmol. 99(10), 1388–1395 (2015).
[PubMed]

Cell Tissue Bank. (1)

J. T. Lie, C. Monnereau, E. A. Groeneveld-van Beek, J. van der Wees, J. Frank, M. Bruinsma, and G. R. J. Melles, “Dehydration of corneal anterior donor tissue with polyethylene glycol (PEG)-enriched media,” Cell Tissue Bank. 16(3), 399–409 (2015).
[PubMed]

Cornea (8)

V. Romano, B. Steger, J. Y. Chen, S. Hassaan, M. Batterbury, C. E. Willoughby, S. Ahmad, A. Elsheikh, and S. B. Kaye, “Reliability of the Effect of Artificial Anterior Chamber Pressure and Corneal Drying on Corneal Graft Thickness,” Cornea 34(8), 866–869 (2015).
[PubMed]

A. C. Schnitzler, S. Salla, N. Hamsley, A. Flammersfeld, M. Fuest, P. Walter, and M. Hermel, “Role of the endothelial layer in the deswelling process of organ-cultured human corneas before transplantation,” Cornea 35(9), 1216–1221 (2016).
[PubMed]

E. Nielsen, A. Ivarsen, M. Erlandsen, and J. Hjortdal, “Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty,” Cornea 35(6), 878–883 (2016).
[PubMed]

A. H. Wolf, U. C. Welge-Lüssen, S. Priglinger, D. Kook, M. Grueterich, K. Hartmann, A. Kampik, and A. S. Neubauer, “Optimizing the Deswelling Process of Organ-Cultured Corneas,” Cornea 28(5), 524–529 (2009).
[PubMed]

C. Kelliher, C. Engler, C. Speck, D. Ward, S. Farazdaghi, and A. S. Jun, “A comprehensive analysis of eye bank-prepared posterior lamellar corneal tissue for use in endothelial keratoplasty,” Cornea 28(9), 966–970 (2009).
[PubMed]

E. Pels and Y. Schuchard, “The effects of high molecular weight dextran on the preservation of human corneas,” Cornea 3(3), 219–227 (1985).
[PubMed]

A. S. Neubauer, S. G. Priglinger, M. J. Thiel, C. A. May, and U. C. Welge-Lüssen, “Sterile structural imaging of donor cornea by optical coherence tomography,” Cornea 21(5), 490–494 (2002).
[PubMed]

C. Y. Choi, D. J. Youm, M. J. Kim, and H. Tchah, “Changes in Central Corneal Thickness of Preserved Corneas Over Time Measured Using Anterior Segment Optical Coherence Tomography,” Cornea 28(5), 536–540 (2009).
[PubMed]

Curr. Eye Res. (1)

C. Redbrake, S. Salla, R. Nilius, J. Becker, and M. Reim, “A histochemical study of the distribution of dextran 500 in human corneas during organ culture,” Curr. Eye Res. 16(5), 405–411 (1997).
[PubMed]

Curr. Opin. Ophthalmol. (1)

B. H. Jeng, “Preserving the cornea: corneal storage media,” Curr. Opin. Ophthalmol. 17(4), 332–337 (2006).
[PubMed]

Dev. Ophthalmol. (1)

E. Pels and W. J. Rijneveld, “Organ culture preservation for corneal tissue. Technical and quality aspects,” Dev. Ophthalmol. 43, 31–46 (2009).
[PubMed]

Exp. Eye Res. (1)

B. O. Hedbys and S. Mishima, “The thickness-hydration relationship of the cornea,” Exp. Eye Res. 5(3), 221–228 (1966).
[PubMed]

Eye Vis (Lond) (1)

D. Williams, Y. Zheng, F. Bao, and A. Elsheikh, “Fast segmentation of anterior segment optical coherence tomography images using graph cut,” Eye Vis (Lond) 2, 1 (2015).
[PubMed]

Graefes Arch. Clin. Exp. Ophthalmol. (2)

V. A. Smith and T. K. Johnson, “Identification and evaluation of a thinning agent compatible with MegaCell DCS, an animal product-free corneal storage medium,” Graefes Arch. Clin. Exp. Ophthalmol. 250(12), 1777–1786 (2012).
[PubMed]

F. Bucher, S. Roters, A. Mellein, D. Hos, L. M. Heindl, C. Cursiefen, and M. Hermann, ““OSMO-UT-DSAEK” using THIN-C medium,” Graefes Arch. Clin. Exp. Ophthalmol. 251(9), 2181–2185 (2013).
[PubMed]

IEEE Trans. Pattern Anal. Mach. Intell. (1)

Y. Boykov, O. Veksler, and R. Zabih, “Fast approximate energy minimization via graph cuts,” IEEE Trans. Pattern Anal. Mach. Intell. 23, 1222–1239 (2001).

Invest. Ophthalmol. Vis. Sci. (6)

K. Wacker, J. W. McLaren, K. M. Kane, K. H. Baratz, and S. V. Patel, “Corneal Hydration Control in Fuchs’ Endothelial Corneal Dystrophy,” Invest. Ophthalmol. Vis. Sci. 57(11), 5060–5065 (2016).
[PubMed]

N. Hutchings, T. L. Simpson, C. Hyun, A. A. Moayed, S. Hariri, L. Sorbara, and K. Bizheva, “Swelling of the Human Cornea Revealed by High-speed, Ultrahigh-Resolution Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 51(9), 4579–4584 (2010).
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Supplementary Material (2)

NameDescription
» Visualization 1       A video stream of automated successive OCT structural images and their segmentation, taken during a de-swelling experiment of 18.5 hours
» Visualization 2       The corresponding deformation velocity images of Video1.avi.

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Figures (4)

Fig. 1
Fig. 1

(a-d) OCT images and graph search segmentation (red lines) of a de-swelling human cornea within a vial at four different times. Visualization 1 shows a video stream of all 156 successive images taken during a de-swelling experiment of 18.5 hours. (e) Measured mean thickness of the de-swelling of three corneas. The locations of the four images in (a-d) are marked with blue circles. A constant group refractive index of 1.37 has been assumed, though the changing composition of the cornea would lead to small variances in this value. (f-g) Representative higher resolution OCT (f) and haematoxylin and eosin histological images (g) zoomed to show the residual epithelial layer (highlighted with red and black lines respectively).

Fig. 2
Fig. 2

The Deformation Velocity Images (DVI) at four times during the de-swelling of a cornea with an intact epithelial layer. Visualization 2 shows the sequence of images up to 552 minutes.

Fig. 3
Fig. 3

(a) Thickness results for a pair of corneas, one with and one without endothelial and Descemet’s layers. (b,c) Comparison DVI images at 0 minutes for both corneas. (d) Averaged, from the endothelial interface, deformation velocities for both corneas.

Fig. 4
Fig. 4

(a) Comparison of measured (blue points) and modelled (red line) mean thicknesses of a cornea over the first 92 minutes of a de-swelling experiment. The offset starting time and thickness of the model is shown by the red circle, with the red dashed line showing the modelled thickness relationship before the first measurement. The blue circles mark the three measurements shown in (b). (b) Comparison of the measured (points) and modelled (lines) mean deformation velocities as a function of distance from the endothelium interface, at three chosen times. The parameters for the model were fitted using these three measured deformation velocity data sets. The fitted parameters are given in Table 1.

Tables (1)

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Table 1 Parameter values, and comparison referenced values, used in mathematical model.

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

I P ΄ = A P ( a P + b P i)= A P a P + A P b P i.
ϕ P = tan 1 ( b P a P )= tan 1 ( A P b P A P a P ).
v= Δϕλ 4πnΔτ = dϕ dτ λ 4πn ,
v r = d( ϕ P ϕ RP ) dτ λ 4πn .