Abstract

We propose a novel suite of algorithms for automatically segmenting the airway lumen and mucus in endobronchial optical coherence tomography (OCT) data sets, as well as a novel approach for quantifying the contents of the mucus. Mucus and lumen were segmented using a robust, multi-stage algorithm that requires only minimal input regarding sheath geometry. The algorithm performance was highly accurate in a wide range of airway and noise conditions. Mucus was classified using mean backscattering intensity and grey level co-occurrence matrix (GLCM) statistics. We evaluated our techniques in vivo in asthmatic and non-asthmatic volunteers.

© 2017 Optical Society of America

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]

2016 (5)

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, and G. W. Canonica, “A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma,” Int. Arch. Allergy Immunol. 170(2), 122–131 (2016).
[Crossref] [PubMed]

A. L. Durham, G. Caramori, K. F. Chung, and I. M. Adcock, “Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease,” Transl. Res. 167(1), 192–203 (2016).
[Crossref] [PubMed]

G. J. Ughi, M. J. Gora, A. F. Swager, A. Soomro, C. Grant, A. Tiernan, M. Rosenberg, J. S. Sauk, N. S. Nishioka, and G. J. Tearney, “Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy,” Biomed. Opt. Express 7(2), 409–419 (2016).
[Crossref] [PubMed]

2015 (3)

2014 (2)

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

2013 (3)

A. M. Pagnozzi, R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Automated quantification of lung structures from optical coherence tomography images,” Biomed. Opt. Express 4(11), 2383–2395 (2013).
[Crossref] [PubMed]

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

R. Kafieh, H. Rabbani, and S. Kermani, “A review of algorithms for segmentation of optical coherence tomography from retina,” J. Med. Signals Sens. 3(1), 45–60 (2013).
[PubMed]

2012 (1)

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

2011 (2)

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Q. Yang, C. A. Reisman, K. Chan, R. Ramachandran, A. Raza, and D. C. Hood, “Automated segmentation of outer retinal layers in macular OCT images of patients with retinitis pigmentosa,” Biomed. Opt. Express 2(9), 2493–2503 (2011).
[Crossref] [PubMed]

2010 (1)

J. V. Fahy and B. F. Dickey, “Airway mucus function and dysfunction,” N. Engl. J. Med. 363(23), 2233–2247 (2010).
[Crossref] [PubMed]

2008 (3)

C. E. Honeycutt and R. Plotnick, “Image analysis techniques and gray-level co-occurrence matrices (GLCM) for calculating bioturbation indices and characterizing biogenic sedimentary structures,” Comput. Geosci. 34(11), 1461–1472 (2008).
[Crossref]

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

2007 (3)

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster, “Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway,” J. Immunol. 179(3), 1901–1912 (2007).
[Crossref] [PubMed]

2006 (1)

S. Y. Thomas, C. M. Lilly, and A. D. Luster, “Invariant natural killer T cells in bronchial asthma,” N. Engl. J. Med. 354(24), 2613–2616 (2006).
[Crossref] [PubMed]

2003 (1)

2002 (1)

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

1999 (1)

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

1959 (1)

E. W. Dijkstra, “A note on two problems in connexion with graphs,” Numer. Math. 1(1), 269–271 (1959).
[Crossref]

Adams, D. C.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Adcock, I. M.

A. L. Durham, G. Caramori, K. F. Chung, and I. M. Adcock, “Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease,” Transl. Res. 167(1), 192–203 (2016).
[Crossref] [PubMed]

Afshar, R.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

Albertucci, M.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Allingham, M. J.

Antoniadis, A. P.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Aretz, H. T.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Armstrong, J. J.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Asanani, N.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Bagnasco, D.

D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, and G. W. Canonica, “A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma,” Int. Arch. Allergy Immunol. 170(2), 122–131 (2016).
[Crossref] [PubMed]

Baker, V. A.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Baldwin, C.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Banerji, A.

S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster, “Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway,” J. Immunol. 179(3), 1901–1912 (2007).
[Crossref] [PubMed]

Biondi-Zoccai, G.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Boppart, S. A.

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
[Crossref] [PubMed]

Boucher, R.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Bouki, K.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Bouma, B. E.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
[Crossref] [PubMed]

Brezinski, M. E.

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
[Crossref] [PubMed]

Burzotta, F.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Canonica, G. W.

D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, and G. W. Canonica, “A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma,” Int. Arch. Allergy Immunol. 170(2), 122–131 (2016).
[Crossref] [PubMed]

Caramori, G.

A. L. Durham, G. Caramori, K. F. Chung, and I. M. Adcock, “Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease,” Transl. Res. 167(1), 192–203 (2016).
[Crossref] [PubMed]

Causton, B.

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

Cense, B.

Chan, K.

Chan, R. C.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Chatzizisis, Y. S.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Cheimariotis, G.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Chen, Z.

Chiu, S. J.

Cho, J. L.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

Choi, K. B.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Chouvarda, I.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Chung, K. F.

A. L. Durham, G. Caramori, K. F. Chung, and I. M. Adcock, “Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease,” Transl. Res. 167(1), 192–203 (2016).
[Crossref] [PubMed]

Conditt, G. B.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Cousins, S. W.

Cremonesi, A.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Curatolo, A.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Dai, C.

de Boer, J.

de Boer, J. F.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

Denniston, A. K.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Desjardins, A. E.

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

Di Vito, L.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Dick, A. D.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Dickey, B. F.

J. V. Fahy and B. F. Dickey, “Airway mucus function and dysfunction,” N. Engl. J. Med. 363(23), 2233–2247 (2010).
[Crossref] [PubMed]

Dijkstra, E. W.

E. W. Dijkstra, “A note on two problems in connexion with graphs,” Numer. Math. 1(1), 269–271 (1959).
[Crossref]

Doulaverakis, C.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Durham, A. L.

A. L. Durham, G. Caramori, K. F. Chung, and I. M. Adcock, “Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease,” Transl. Res. 167(1), 192–203 (2016).
[Crossref] [PubMed]

Eastwood, P. R.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

et,

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Evans, J. A.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

Fahy, J. V.

J. V. Fahy and B. F. Dickey, “Airway mucus function and dysfunction,” N. Engl. J. Med. 363(23), 2233–2247 (2010).
[Crossref] [PubMed]

Farsiu, S.

Faustino, L.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Ferrando, M.

D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, and G. W. Canonica, “A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma,” Int. Arch. Allergy Immunol. 170(2), 122–131 (2016).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Ford, A. A.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Fujimoto, J. G.

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
[Crossref] [PubMed]

Gallagher, K. A.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Gazdar, A.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Giannoglou, G. D.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Giannopoulos, A.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Gora, M. J.

Granada, J. F.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Grant, C.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Griffith, J. W.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Hamilos, D. L.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

Han, A. K.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Hariri, L. P.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

Harris, R. S.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Heidari, A. E.

Hillman, D. R.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Holz, J. A.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
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Honeycutt, C. E.

C. E. Honeycutt and R. Plotnick, “Image analysis techniques and gray-level co-occurrence matrices (GLCM) for calculating bioturbation indices and characterizing biogenic sedimentary structures,” Comput. Geosci. 34(11), 1461–1472 (2008).
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Hood, D. C.

Houser, S. L.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Huang, S.

Ikeda, N.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Imola, F.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Islam, S. A.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Izatt, J. A.

James, A. L.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Jang, I. K.

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Kafieh, R.

R. Kafieh, H. Rabbani, and S. Kermani, “A review of algorithms for segmentation of optical coherence tomography from retina,” J. Med. Signals Sens. 3(1), 45–60 (2013).
[PubMed]

Kaluza, G. L.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Kang, D. H.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Karampelas, M.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Kashiwagi, M.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Keane, P. A.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Kennedy, B. F.

Kermani, S.

R. Kafieh, H. Rabbani, and S. Kermani, “A review of algorithms for segmentation of optical coherence tomography from retina,” J. Med. Signals Sens. 3(1), 45–60 (2013).
[PubMed]

Kesimer, M.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Kirk, R. W.

Kompatsiaris, I.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Koutkias, V. G.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Kwok, W. W.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

La Manna, A.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Lam, S.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Lauwers, G. Y.

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

Lee, R. W.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

leRiche, J.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Lilly, C. M.

S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster, “Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway,” J. Immunol. 179(3), 1901–1912 (2007).
[Crossref] [PubMed]

S. Y. Thomas, C. M. Lilly, and A. D. Luster, “Invariant natural killer T cells in bronchial asthma,” N. Engl. J. Med. 354(24), 2613–2616 (2006).
[Crossref] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Ling, M. F.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Luster, A. D.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster, “Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway,” J. Immunol. 179(3), 1901–1912 (2007).
[Crossref] [PubMed]

S. Y. Thomas, C. M. Lilly, and A. D. Luster, “Invariant natural killer T cells in bronchial asthma,” N. Engl. J. Med. 354(24), 2613–2616 (2006).
[Crossref] [PubMed]

MacAulay, C.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Maglaveras, N.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Manzoli, A.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Marks, G. B.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Materia, L.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

McLaughlin, R. A.

A. M. Pagnozzi, R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Automated quantification of lung structures from optical coherence tomography images,” Biomed. Opt. Express 4(11), 2383–2395 (2013).
[Crossref] [PubMed]

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

McWilliams, A.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Medoff, B. D.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster, “Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway,” J. Immunol. 179(3), 1901–1912 (2007).
[Crossref] [PubMed]

Mettu, P. S.

Milewski, K.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Miller, A. J.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

Mino-Kenudson, M.

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

Moon, J. J.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Murray, P. I.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
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Nadkarni, S. K.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Ng, A.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
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Nishioka, N. S.

G. J. Ughi, M. J. Gora, A. F. Swager, A. Soomro, C. Grant, A. Tiernan, M. Rosenberg, J. S. Sauk, N. S. Nishioka, and G. J. Tearney, “Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy,” Biomed. Opt. Express 7(2), 409–419 (2016).
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M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

Noffsinger, W. J.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Nussenblatt, R. B.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Occhipinti, M.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

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S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

Pagnozzi, A. M.

Park, B.

Park, S. J.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
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Park, S. W.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
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D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, and G. W. Canonica, “A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma,” Int. Arch. Allergy Immunol. 170(2), 122–131 (2016).
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[Crossref] [PubMed]

Pierce, M.

Pitris, C.

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
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C. E. Honeycutt and R. Plotnick, “Image analysis techniques and gray-level co-occurrence matrices (GLCM) for calculating bioturbation indices and characterizing biogenic sedimentary structures,” Comput. Geosci. 34(11), 1461–1472 (2008).
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I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Porto, I.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
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Prati, F.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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Qi, L.

Rabbani, H.

R. Kafieh, H. Rabbani, and S. Kermani, “A review of algorithms for segmentation of optical coherence tomography from retina,” J. Med. Signals Sens. 3(1), 45–60 (2013).
[PubMed]

Radicioni, G.

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[Crossref] [PubMed]

Ramachandran, R.

Ramazzotti, V.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
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Raza, A.

Regli, A.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
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Reisman, C. A.

Riga, M.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
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Rosenberg, M.

Sadda, S. R.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
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Sampson, D. D.

A. M. Pagnozzi, R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Automated quantification of lung structures from optical coherence tomography images,” Biomed. Opt. Express 4(11), 2383–2395 (2013).
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J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Sauk, J. S.

Schlendorf, K.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Scott Harris, R.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

Sen, H. N.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Seung, E.

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

Seung, K. B.

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Shepherd, K. L.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Shishko, M.

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

Shishkov, M.

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

Sim, D. A.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Soomro, A.

Standish, B.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Stefanadis, C.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Strassner, J. P.

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

Suter, M. J.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

Swager, A. F.

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Szabari, M. V.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

Tamburino, C.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Tanaka, A.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Tearney, G. J.

G. J. Ughi, M. J. Gora, A. F. Swager, A. Soomro, C. Grant, A. Tiernan, M. Rosenberg, J. S. Sauk, N. S. Nishioka, and G. J. Tearney, “Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy,” Biomed. Opt. Express 7(2), 409–419 (2016).
[Crossref] [PubMed]

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
[Crossref] [PubMed]

Tellez, A.

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

Thomas, S. Y.

S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster, “Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway,” J. Immunol. 179(3), 1901–1912 (2007).
[Crossref] [PubMed]

S. Y. Thomas, C. M. Lilly, and A. D. Luster, “Invariant natural killer T cells in bronchial asthma,” N. Engl. J. Med. 354(24), 2613–2616 (2006).
[Crossref] [PubMed]

Tiernan, A.

Toutouzas, K.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Trani, C.

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Tsampoulatidis, I.

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Tufail, A.

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Ughi, G. J.

Vakoc, B. J.

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

Varricchi, G.

D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, and G. W. Canonica, “A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma,” Int. Arch. Allergy Immunol. 170(2), 122–131 (2016).
[Crossref] [PubMed]

Villiger, M.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

Vitkin, A. I.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Wang, Y.

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

Williamson, J. P.

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Xavier, R.

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Yachimski, P. S.

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

Yang, Q.

Yang, V.

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Yun, S. H.

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
[Crossref] [PubMed]

Zhang, X.

Zhu, J.

Am. J. Respir. Crit. Care Med. (1)

J. P. Williamson, R. A. McLaughlin, W. J. Noffsinger, A. L. James, V. A. Baker, A. Curatolo, J. J. Armstrong, A. Regli, K. L. Shepherd, G. B. Marks, D. D. Sampson, D. R. Hillman, and P. R. Eastwood, “Elastic properties of the central airways in obstructive lung diseases measured using anatomical optical coherence tomography,” Am. J. Respir. Crit. Care Med. 183(5), 612–619 (2011).
[Crossref] [PubMed]

Biomed. Opt. Express (4)

Clin. Cancer Res. (1)

S. Lam, B. Standish, C. Baldwin, A. McWilliams, J. leRiche, A. Gazdar, A. I. Vitkin, V. Yang, N. Ikeda, and C. MacAulay, “In vivo optical coherence tomography imaging of preinvasive bronchial lesions,” Clin. Cancer Res. 14(7), 2006–2011 (2008).
[Crossref] [PubMed]

Comput. Geosci. (1)

C. E. Honeycutt and R. Plotnick, “Image analysis techniques and gray-level co-occurrence matrices (GLCM) for calculating bioturbation indices and characterizing biogenic sedimentary structures,” Comput. Geosci. 34(11), 1461–1472 (2008).
[Crossref]

EuroIntervention (1)

F. Prati, L. Di Vito, G. Biondi-Zoccai, M. Occhipinti, A. La Manna, C. Tamburino, F. Burzotta, C. Trani, I. Porto, V. Ramazzotti, F. Imola, A. Manzoli, L. Materia, A. Cremonesi, and M. Albertucci, “Angiography alone versus angiography plus optical coherence tomography to guide decision-making during percutaneous coronary intervention: the Centro per la Lotta contro l’Infarto-Optimisation of Percutaneous Coronary Intervention (CLI-OPCI) study,” EuroIntervention 8(7), 823–829 (2012).
[Crossref] [PubMed]

Gastrointest. Endosc. (2)

B. J. Vakoc, M. Shishko, S. H. Yun, W. Y. Oh, M. J. Suter, A. E. Desjardins, J. A. Evans, N. S. Nishioka, G. J. Tearney, and B. E. Bouma, “Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video),” Gastrointest. Endosc. 65(6), 898–905 (2007).
[Crossref] [PubMed]

M. J. Suter, B. J. Vakoc, P. S. Yachimski, M. Shishkov, G. Y. Lauwers, M. Mino-Kenudson, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging,” Gastrointest. Endosc. 68(4), 745–753 (2008).
[Crossref] [PubMed]

Heart (1)

J. G. Fujimoto, S. A. Boppart, G. J. Tearney, B. E. Bouma, C. Pitris, and M. E. Brezinski, “High resolution in vivo intra-arterial imaging with optical coherence tomography,” Heart 82(2), 128–133 (1999).
[Crossref] [PubMed]

Int. Arch. Allergy Immunol. (1)

D. Bagnasco, M. Ferrando, G. Varricchi, G. Passalacqua, and G. W. Canonica, “A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma,” Int. Arch. Allergy Immunol. 170(2), 122–131 (2016).
[Crossref] [PubMed]

Int. J. Cardiol. (1)

Y. S. Chatzizisis, V. G. Koutkias, K. Toutouzas, A. Giannopoulos, I. Chouvarda, M. Riga, A. P. Antoniadis, G. Cheimariotis, C. Doulaverakis, I. Tsampoulatidis, K. Bouki, I. Kompatsiaris, C. Stefanadis, N. Maglaveras, and G. D. Giannoglou, “Clinical validation of an algorithm for rapid and accurate automated segmentation of intracoronary optical coherence tomography images,” Int. J. Cardiol. 172(3), 568–580 (2014).
[Crossref] [PubMed]

Int. J. Cardiovasc. Imaging (1)

M. J. Suter, M. Kashiwagi, K. A. Gallagher, S. K. Nadkarni, N. Asanani, A. Tanaka, G. B. Conditt, A. Tellez, K. Milewski, G. L. Kaluza, J. F. Granada, B. E. Bouma, and G. J. Tearney, “Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study,” Int. J. Cardiovasc. Imaging 31(6), 1097–1106 (2015).
[Crossref] [PubMed]

J. Allergy Clin. Immunol. (1)

R. Afshar, J. P. Strassner, E. Seung, B. Causton, J. L. Cho, R. S. Harris, D. L. Hamilos, B. D. Medoff, and A. D. Luster, “Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation,” J. Allergy Clin. Immunol. 131(6), 1644–1652 (2013).
[Crossref] [PubMed]

J. Am. Coll. Cardiol. (1)

I. K. Jang, B. E. Bouma, D. H. Kang, S. J. Park, S. W. Park, K. B. Seung, K. B. Choi, M. Shishkov, K. Schlendorf, E. Pomerantsev, S. L. Houser, H. T. Aretz, and G. J. Tearney, “Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound,” J. Am. Coll. Cardiol. 39(4), 604–609 (2002).
[Crossref] [PubMed]

J. Immunol. (1)

S. Y. Thomas, A. Banerji, B. D. Medoff, C. M. Lilly, and A. D. Luster, “Multiple chemokine receptors, including CCR6 and CXCR3, regulate antigen-induced T cell homing to the human asthmatic airway,” J. Immunol. 179(3), 1901–1912 (2007).
[Crossref] [PubMed]

J. Med. Signals Sens. (1)

R. Kafieh, H. Rabbani, and S. Kermani, “A review of algorithms for segmentation of optical coherence tomography from retina,” J. Med. Signals Sens. 3(1), 45–60 (2013).
[PubMed]

N. Engl. J. Med. (2)

J. V. Fahy and B. F. Dickey, “Airway mucus function and dysfunction,” N. Engl. J. Med. 363(23), 2233–2247 (2010).
[Crossref] [PubMed]

S. Y. Thomas, C. M. Lilly, and A. D. Luster, “Invariant natural killer T cells in bronchial asthma,” N. Engl. J. Med. 354(24), 2613–2616 (2006).
[Crossref] [PubMed]

Nat. Med. (1)

S. H. Yun, G. J. Tearney, B. J. Vakoc, M. Shishkov, W. Y. Oh, A. E. Desjardins, M. J. Suter, R. C. Chan, J. A. Evans, I. K. Jang, N. S. Nishioka, J. F. de Boer, and B. E. Bouma, “Comprehensive volumetric optical microscopy in vivo,” Nat. Med. 12(12), 1429–1433 (2007).
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Numer. Math. (1)

E. W. Dijkstra, “A note on two problems in connexion with graphs,” Numer. Math. 1(1), 269–271 (1959).
[Crossref]

Ophthalmology (1)

P. A. Keane, M. Karampelas, D. A. Sim, S. R. Sadda, A. Tufail, H. N. Sen, R. B. Nussenblatt, A. D. Dick, R. W. Lee, P. I. Murray, C. E. Pavesio, and A. K. Denniston, “Objective measurement of vitreous inflammation using optical coherence tomography,” Ophthalmology 121(9), 1706–1714 (2014).
[Crossref] [PubMed]

Opt. Express (2)

Sci. Transl. Med. (2)

D. C. Adams, L. P. Hariri, A. J. Miller, Y. Wang, J. L. Cho, M. Villiger, J. A. Holz, M. V. Szabari, D. L. Hamilos, R. Scott Harris, J. W. Griffith, B. E. Bouma, A. D. Luster, B. D. Medoff, and M. J. Suter, “Birefringence microscopy platform for assessing airway smooth muscle structure and function in vivo,” Sci. Transl. Med. 8(359), 359ra131 (2016).
[Crossref] [PubMed]

J. L. Cho, M. F. Ling, D. C. Adams, L. Faustino, S. A. Islam, R. Afshar, J. W. Griffith, R. S. Harris, A. Ng, G. Radicioni, A. A. Ford, A. K. Han, R. Xavier, W. W. Kwok, R. Boucher, J. J. Moon, D. L. Hamilos, M. Kesimer, M. J. Suter, B. D. Medoff, and A. D. Luster, “Allergic asthma is distinguished by sensitivity of allergen-specific CD4+ T cells and airway structural cells to type 2 inflammation,” Sci. Transl. Med. 8(359), 359ra132 (2016).
[Crossref] [PubMed]

Science (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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A. L. Durham, G. Caramori, K. F. Chung, and I. M. Adcock, “Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease,” Transl. Res. 167(1), 192–203 (2016).
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Figures (8)

Fig. 1
Fig. 1 Flow diagram illustrating the main steps of the segmentation and analysis algorithms.
Fig. 2
Fig. 2 Segmentation of catheter sheath. (a) Input image. (b) Approximate location of sheath segmented based on known sheath dimensions. (c) Artificial sheath signal. (d) Position of maximum cross-correlation of artificial sheath signal with segmented image from (b). (e) Sheath fit after minor adjustments made based on image intensity. (f) Final sheath fit, after applying a smoothing filter to (e). In this figure the circularization offset has been artificially increased and the images cropped to make the figure clearer, and the scale bar was determined relative to the outer surface of the sheath. Scale bars, 0.5 mm.
Fig. 3
Fig. 3 Segmentation of airway lumen. (a) Input image. (b) Input image after Wiener Filter is applied. (c) Thresholding and (d) binarization. (e) Surface segments are identified and (f) cost matrix analysis is used to identify the best path. (g) The process is repeated in regions where no lumen surface was found by reapplying a threshold to the filtered image calculated from the mean pixel intensity within the region. The lumen fit is then obtained and represented in (h) polar and (i) Cartesian coordinates. (a-h) vertical scale bars, 0.5 mm; horizontal scale bars, 30°. (i) scale bar, 0.5 mm.
Fig. 4
Fig. 4 Segmentation of airway mucus. (a) The input image. (b) The image after filtering and thresholding are performed. (c) Morphological operations are performed to remove artifacts (blue arrows). (d) The resulting binary mask, (e) applied to image (b). The segmented mucus is color coded yellow in (f) polar and (g) Cartesian coordinates. a-f) vertical scale bars, 0.5 mm; horizontal scale bars, 30°. (g) scale bar, 0.5 mm.
Fig. 5
Fig. 5 Mucus GLCM statistics comparison. (a) Intensity image with mucus color coded in yellow. (b-e) GLCM statistic values using a 20x20 sliding window for (b) Contrast, (c) Correlation, (d) Entropy, and (e) Homogeneity. Scale bars, 0.5 mm.
Fig. 6
Fig. 6 Representation of how mucus analysis is performed volumetrically. The mucus was divided into 3D slices 50x50 pixels in area and 5 frames thick (Represented by blue wireframe), and a mean filter 6x6x2 in size was used to reduce the effect of speckle. Each 3d slice was then analyzed along each of the 3 orthogonal directions using a GLCM with a pixel separation of 1.
Fig. 7
Fig. 7 Results from manual segmentation. (a-c) Volumetric representations from a representative airway segmented using the automated methods are shown for (a) lumen, (b) mucus, and (c) sheath. (d,e) Comparison between manual and automated segmentation for (d) lumen and (e) mucus.
Fig. 8
Fig. 8 Comparison of various OCT mucus assessment approaches with mucin content obtained from BAL. (a) Mean pixel intensity. (b-e) GLCM statistics corresponding to (b) Contrast, (c) Homogeneity, (d) Correlation, and (e) Energy. Mean pixel intensity, GLCM Contrast, and GLCM Homogeneity were found to be correlated with mucin, with GLCM Contrast presenting the best correlation.

Equations (10)

Equations on this page are rendered with MathJax. Learn more.

C(k,l)= x,y I(x,y)S(xk,yl)
I f (x,y)= μ l (x,y)( σ l 2 (x,y) ν 2 σ l 2 (x,y) )[I(x,y) μ l (x,y)]
I(x,y)<1.5μ+σI(x,y):=0
I(x,y)I(x,y1)
Edg e i,j =( Ω i,j +1) Γ i,j
Ω i,j = Δ x i,j 2 +min ( m i,j ,5) 2 Δ y i,j 2
Contrast= i,j | i,j | 2 p(i,j)
Correlation= i,j (iμi)(jμj)p(i,j) σ i σ j
Energy= i,j p (i,j) 2
Homogeneity= i,j p(i,j) 1+| i,j |

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