Abstract

Several optical imaging techniques have been applied for high-resolution embryonic imaging using different contrast mechanisms, each with their own benefits and limitations. In this study, we imaged the same E9.5 mouse embryo with rotational imaging optical coherence tomography (RI-OCT) and selective plane illumination microscopy (SPIM). RI-OCT overcomes optical penetration limits of traditional OCT imaging that prohibit full-body imaging of mouse embryos at later stages by imaging the samples from multiple angles. SPIM enables high-resolution, 3D imaging with less phototoxicity and photobleaching than laser scanning confocal microscopy (LSCM) by illuminating the sample with a focused sheet of light. Side by side comparisons are supplemented with co-registered images. The results demonstrate that SPIM and RI-OCT are highly complementary and could provide more comprehensive tissue characterization for mouse embryonic research.

© 2017 Optical Society of America

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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2017 (2)

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
[Crossref] [PubMed]

S. Wang, M. D. Garcia, A. L. Lopez, P. A. Overbeek, K. V. Larin, and I. V. Larina, “Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography,” Biomed. Opt. Express 8(1), 407–419 (2017).
[Crossref] [PubMed]

2016 (6)

M. Singh, R. Raghunathan, V. Piazza, A. M. Davis-Loiacono, A. Cable, T. J. Vedakkan, T. Janecek, M. V. Frazier, A. Nair, C. Wu, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography,” Biomed. Opt. Express 7(6), 2295–2310 (2016).
[Crossref] [PubMed]

J. Icha, C. Schmied, J. Sidhaye, P. Tomancak, S. Preibisch, and C. Norden, “Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development,” J. Vis. Exp. 110, e53966 (2016).
[PubMed]

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
[Crossref] [PubMed]

J. Fujimoto and E. Swanson, “The Development, Commercialization, and Impact of Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 57(9), 1–13 (2016).
[Crossref] [PubMed]

R. Raghunathan, M. Singh, M. E. Dickinson, and K. V. Larin, “Optical coherence tomography for embryonic imaging: a review,” J. Biomed. Opt. 21(5), 050902 (2016).
[Crossref] [PubMed]

C. Wu, N. Sudheendran, M. Singh, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Rotational imaging optical coherence tomography for full-body mouse embryonic imaging,” J. Biomed. Opt. 21(2), 026002 (2016).
[Crossref] [PubMed]

2015 (2)

2014 (5)

J. Mayer, A. Robert-Moreno, R. Danuser, J. V. Stein, J. Sharpe, and J. Swoger, “OPTiSPIM: integrating optical projection tomography in light sheet microscopy extends specimen characterization to nonfluorescent contrasts,” Opt. Lett. 39(4), 1053–1056 (2014).
[Crossref] [PubMed]

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
[Crossref] [PubMed]

D. P. Clark and C. T. Badea, “Micro-CT of rodents: state-of-the-art and future perspectives,” Phys. Med. 30(6), 619–634 (2014).
[Crossref] [PubMed]

M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
[Crossref] [PubMed]

R. S. Udan, V. G. Piazza, C. W. Hsu, A. K. Hadjantonakis, and M. E. Dickinson, “Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy,” Development 141(22), 4406–4414 (2014).
[Crossref] [PubMed]

2013 (1)

D. Zhu, K. V. Larin, Q. Luo, and V. V. Tuchin, “Recent progress in tissue optical clearing,” Laser Photonics Rev. 7(5), 732–757 (2013).
[Crossref] [PubMed]

2012 (2)

A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
[Crossref] [PubMed]

M. W. Jenkins, M. Watanabe, and A. M. Rollins, “Longitudinal Imaging of Heart Development With Optical Coherence Tomography,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1166–1175 (2012).
[Crossref] [PubMed]

2011 (4)

S. H. Syed, K. V. Larin, M. E. Dickinson, and I. V. Larina, “Optical coherence tomography for high-resolution imaging of mouse development in utero,” J. Biomed. Opt. 16(4), 046004 (2011).
[Crossref] [PubMed]

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

N. Sudheendran, S. Syed, M. Dickinson, I. Larina, and K. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett. 8(3), 247–252 (2011).
[Crossref]

G. Liu, W. Qi, L. Yu, and Z. Chen, “Real-time bulk-motion-correction free Doppler variance optical coherence tomography for choroidal capillary vasculature imaging,” Opt. Express 19(4), 3657–3666 (2011).
[Crossref] [PubMed]

2010 (1)

B. J. Nieman and D. H. Turnbull, “Ultrasound and Magnetic Resonance Microimaging of Mouse Development,” Methods Enzymol. 476, 379–400 (2010).
[Crossref] [PubMed]

2009 (6)

S. R. Montezuma, D. Vavvas, and J. W. Miller, “Review of the ocular angiogenesis animal models,” Semin. Ophthalmol. 24(2), 52–61 (2009).
[Crossref] [PubMed]

J. Huisken and D. Y. Stainier, “Selective plane illumination microscopy techniques in developmental biology,” Development 136(12), 1963–1975 (2009).
[Crossref] [PubMed]

R. K. Ejsmont, M. Sarov, S. Winkler, K. A. Lipinski, and P. Tomancak, “A toolkit for high-throughput, cross-species gene engineering in Drosophila,” Nat. Methods 6(6), 435–437 (2009).
[Crossref] [PubMed]

J. F. Colas and J. Sharpe, “Live optical projection tomography,” Organogenesis 5(4), 211–216 (2009).
[Crossref] [PubMed]

I. V. Larina, S. Ivers, S. Syed, M. E. Dickinson, and K. V. Larin, “Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT,” Opt. Lett. 34(7), 986–988 (2009).
[Crossref] [PubMed]

R. K. Wang and L. An, “Doppler optical micro-angiography for volumetric imaging of vascular perfusion in vivo,” Opt. Express 17(11), 8926–8940 (2009).
[Crossref] [PubMed]

2008 (3)

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
[Crossref] [PubMed]

J. R. Walls, L. Coultas, J. Rossant, and R. M. Henkelman, “Three-dimensional analysis of vascular development in the mouse embryo,” PLoS One 3(8), e2853 (2008).
[Crossref] [PubMed]

P. J. Keller and E. H. Stelzer, “Quantitative in vivo imaging of entire embryos with Digital Scanned Laser Light Sheet Fluorescence Microscopy,” Curr. Opin. Neurobiol. 18(6), 624–632 (2008).
[Crossref] [PubMed]

2007 (3)

B. A. Filas, I. R. Efimov, and L. A. Taber, “Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart,” Anat. Rec. (Hoboken) 290(9), 1057–1068 (2007).
[Crossref] [PubMed]

J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134(18), 3317–3326 (2007).
[Crossref] [PubMed]

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

2006 (3)

N. E. Sharpless and R. A. Depinho, “The mighty mouse: genetically engineered mouse models in cancer drug development,” Nat. Rev. Drug Discov. 5(9), 741–754 (2006).
[Crossref] [PubMed]

M. E. Dickinson, “Multimodal imaging of mouse development: tools for the postgenomic era,” Dev. Dyn. 235(9), 2386–2400 (2006).
[Crossref] [PubMed]

Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
[Crossref] [PubMed]

2004 (1)

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[Crossref] [PubMed]

2001 (1)

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

2000 (1)

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

1991 (1)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Alex, A.

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
[Crossref] [PubMed]

An, L.

Badea, C. T.

D. P. Clark and C. T. Badea, “Micro-CT of rodents: state-of-the-art and future perspectives,” Phys. Med. 30(6), 619–634 (2014).
[Crossref] [PubMed]

Barnett, L.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

Bassi, A.

A. Bassi, B. Schmid, and J. Huisken, “Optical tomography complements light sheet microscopy for in toto imaging of zebrafish development,” Development 142(5), 1016–1020 (2015).
[Crossref] [PubMed]

Becker, K.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Biben, C.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

Bruneau, B. G.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Brunetti, A.

A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
[Crossref] [PubMed]

Cable, A.

Caron, S.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Chang, C. H.

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
[Crossref] [PubMed]

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Charron, F.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
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Chen, J.

J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134(18), 3317–3326 (2007).
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Chen, Z.

Chiou, A.

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
[Crossref] [PubMed]

Choi, J. M.

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
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Cižmár, T.

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
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D. P. Clark and C. T. Badea, “Micro-CT of rodents: state-of-the-art and future perspectives,” Phys. Med. 30(6), 619–634 (2014).
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A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
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J. F. Colas and J. Sharpe, “Live optical projection tomography,” Organogenesis 5(4), 211–216 (2009).
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T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
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B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
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J. R. Walls, L. Coultas, J. Rossant, and R. M. Henkelman, “Three-dimensional analysis of vascular development in the mouse embryo,” PLoS One 3(8), e2853 (2008).
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Dalgarno, H. I.

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
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Davis-Loiacono, A. M.

Deininger, K.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
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Deng, K. Y.

Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
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N. E. Sharpless and R. A. Depinho, “The mighty mouse: genetically engineered mouse models in cancer drug development,” Nat. Rev. Drug Discov. 5(9), 741–754 (2006).
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H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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Dholakia, K.

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
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Dickinson, M.

N. Sudheendran, S. Syed, M. Dickinson, I. Larina, and K. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett. 8(3), 247–252 (2011).
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Dickinson, M. E.

C. Wu, N. Sudheendran, M. Singh, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Rotational imaging optical coherence tomography for full-body mouse embryonic imaging,” J. Biomed. Opt. 21(2), 026002 (2016).
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M. Singh, R. Raghunathan, V. Piazza, A. M. Davis-Loiacono, A. Cable, T. J. Vedakkan, T. Janecek, M. V. Frazier, A. Nair, C. Wu, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography,” Biomed. Opt. Express 7(6), 2295–2310 (2016).
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R. Raghunathan, M. Singh, M. E. Dickinson, and K. V. Larin, “Optical coherence tomography for embryonic imaging: a review,” J. Biomed. Opt. 21(5), 050902 (2016).
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R. S. Udan, V. G. Piazza, C. W. Hsu, A. K. Hadjantonakis, and M. E. Dickinson, “Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy,” Development 141(22), 4406–4414 (2014).
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S. H. Syed, K. V. Larin, M. E. Dickinson, and I. V. Larina, “Optical coherence tomography for high-resolution imaging of mouse development in utero,” J. Biomed. Opt. 16(4), 046004 (2011).
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J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134(18), 3317–3326 (2007).
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M. E. Dickinson, “Multimodal imaging of mouse development: tools for the postgenomic era,” Dev. Dyn. 235(9), 2386–2400 (2006).
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H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

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Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
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Eder, M.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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B. A. Filas, I. R. Efimov, and L. A. Taber, “Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart,” Anat. Rec. (Hoboken) 290(9), 1057–1068 (2007).
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R. K. Ejsmont, M. Sarov, S. Winkler, K. A. Lipinski, and P. Tomancak, “A toolkit for high-throughput, cross-species gene engineering in Drosophila,” Nat. Methods 6(6), 435–437 (2009).
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C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
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Fahrbach, F. O.

M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
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Feneley, M.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
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Ferrier, D. E.

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
[Crossref] [PubMed]

Filas, B. A.

B. A. Filas, I. R. Efimov, and L. A. Taber, “Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart,” Anat. Rec. (Hoboken) 290(9), 1057–1068 (2007).
[Crossref] [PubMed]

Fisher, P. J.

Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
[Crossref] [PubMed]

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Fraser, S. E.

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134(18), 3317–3326 (2007).
[Crossref] [PubMed]

Frazier, M. V.

Fujimoto, J.

J. Fujimoto and E. Swanson, “The Development, Commercialization, and Impact of Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 57(9), 1–13 (2016).
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Garcia, M. D.

Gargiulo, S.

A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
[Crossref] [PubMed]

Gessler, M.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
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Gramanzini, M.

A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
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Greco, A.

A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
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Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
[Crossref] [PubMed]

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Gunn-Moore, F. J.

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
[Crossref] [PubMed]

Hadjantonakis, A. K.

R. S. Udan, V. G. Piazza, C. W. Hsu, A. K. Hadjantonakis, and M. E. Dickinson, “Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy,” Development 141(22), 4406–4414 (2014).
[Crossref] [PubMed]

Harvey, R. P.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Henkelman, R. M.

J. R. Walls, L. Coultas, J. Rossant, and R. M. Henkelman, “Three-dimensional analysis of vascular development in the mouse embryo,” PLoS One 3(8), e2853 (2008).
[Crossref] [PubMed]

Hombach, S.

M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
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Hsu, C. W.

R. S. Udan, V. G. Piazza, C. W. Hsu, A. K. Hadjantonakis, and M. E. Dickinson, “Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy,” Development 141(22), 4406–4414 (2014).
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Huang, C.

J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134(18), 3317–3326 (2007).
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Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
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Huang, Y.

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
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Huang, Y. S.

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
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A. Bassi, B. Schmid, and J. Huisken, “Optical tomography complements light sheet microscopy for in toto imaging of zebrafish development,” Development 142(5), 1016–1020 (2015).
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M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
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J. Huisken and D. Y. Stainier, “Selective plane illumination microscopy techniques in developmental biology,” Development 136(12), 1963–1975 (2009).
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J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
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Icha, J.

J. Icha, C. Schmied, J. Sidhaye, P. Tomancak, S. Preibisch, and C. Norden, “Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development,” J. Vis. Exp. 110, e53966 (2016).
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Ivers, S.

Jährling, N.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
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Janecek, T.

Jenkins, M. W.

M. W. Jenkins, M. Watanabe, and A. M. Rollins, “Longitudinal Imaging of Heart Development With Optical Coherence Tomography,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1166–1175 (2012).
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Jerwick, J.

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
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Jones, E. A. V.

J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134(18), 3317–3326 (2007).
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P. J. Keller and E. H. Stelzer, “Quantitative in vivo imaging of entire embryos with Digital Scanned Laser Light Sheet Fluorescence Microscopy,” Curr. Opin. Neurobiol. 18(6), 624–632 (2008).
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P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
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Kesteven, S.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
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Köentgen, F.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
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Koos, D. S.

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

Kotlikoff, M. I.

Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
[Crossref] [PubMed]

Ku, H. Y.

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
[Crossref] [PubMed]

Larin, K.

N. Sudheendran, S. Syed, M. Dickinson, I. Larina, and K. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett. 8(3), 247–252 (2011).
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Larin, K. V.

S. Wang, M. D. Garcia, A. L. Lopez, P. A. Overbeek, K. V. Larin, and I. V. Larina, “Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography,” Biomed. Opt. Express 8(1), 407–419 (2017).
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M. Singh, R. Raghunathan, V. Piazza, A. M. Davis-Loiacono, A. Cable, T. J. Vedakkan, T. Janecek, M. V. Frazier, A. Nair, C. Wu, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography,” Biomed. Opt. Express 7(6), 2295–2310 (2016).
[Crossref] [PubMed]

R. Raghunathan, M. Singh, M. E. Dickinson, and K. V. Larin, “Optical coherence tomography for embryonic imaging: a review,” J. Biomed. Opt. 21(5), 050902 (2016).
[Crossref] [PubMed]

C. Wu, N. Sudheendran, M. Singh, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Rotational imaging optical coherence tomography for full-body mouse embryonic imaging,” J. Biomed. Opt. 21(2), 026002 (2016).
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S. Wang, M. Singh, A. L. Lopez, C. Wu, R. Raghunathan, A. Schill, J. Li, K. V. Larin, and I. V. Larina, “Direct four-dimensional structural and functional imaging of cardiovascular dynamics in mouse embryos with 1.5 MHz optical coherence tomography,” Opt. Lett. 40(20), 4791–4794 (2015).
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D. Zhu, K. V. Larin, Q. Luo, and V. V. Tuchin, “Recent progress in tissue optical clearing,” Laser Photonics Rev. 7(5), 732–757 (2013).
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S. H. Syed, K. V. Larin, M. E. Dickinson, and I. V. Larina, “Optical coherence tomography for high-resolution imaging of mouse development in utero,” J. Biomed. Opt. 16(4), 046004 (2011).
[Crossref] [PubMed]

I. V. Larina, S. Ivers, S. Syed, M. E. Dickinson, and K. V. Larin, “Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT,” Opt. Lett. 34(7), 986–988 (2009).
[Crossref] [PubMed]

Larina, I.

N. Sudheendran, S. Syed, M. Dickinson, I. Larina, and K. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett. 8(3), 247–252 (2011).
[Crossref]

Larina, I. V.

S. Wang, M. D. Garcia, A. L. Lopez, P. A. Overbeek, K. V. Larin, and I. V. Larina, “Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography,” Biomed. Opt. Express 8(1), 407–419 (2017).
[Crossref] [PubMed]

M. Singh, R. Raghunathan, V. Piazza, A. M. Davis-Loiacono, A. Cable, T. J. Vedakkan, T. Janecek, M. V. Frazier, A. Nair, C. Wu, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography,” Biomed. Opt. Express 7(6), 2295–2310 (2016).
[Crossref] [PubMed]

C. Wu, N. Sudheendran, M. Singh, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Rotational imaging optical coherence tomography for full-body mouse embryonic imaging,” J. Biomed. Opt. 21(2), 026002 (2016).
[Crossref] [PubMed]

S. Wang, M. Singh, A. L. Lopez, C. Wu, R. Raghunathan, A. Schill, J. Li, K. V. Larin, and I. V. Larina, “Direct four-dimensional structural and functional imaging of cardiovascular dynamics in mouse embryos with 1.5 MHz optical coherence tomography,” Opt. Lett. 40(20), 4791–4794 (2015).
[Crossref] [PubMed]

S. H. Syed, K. V. Larin, M. E. Dickinson, and I. V. Larina, “Optical coherence tomography for high-resolution imaging of mouse development in utero,” J. Biomed. Opt. 16(4), 046004 (2011).
[Crossref] [PubMed]

I. V. Larina, S. Ivers, S. Syed, M. E. Dickinson, and K. V. Larin, “Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT,” Opt. Lett. 34(7), 986–988 (2009).
[Crossref] [PubMed]

Leischner, U.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Li, A.

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
[Crossref] [PubMed]

Li, J.

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Lipinski, K. A.

R. K. Ejsmont, M. Sarov, S. Winkler, K. A. Lipinski, and P. Tomancak, “A toolkit for high-throughput, cross-species gene engineering in Drosophila,” Nat. Methods 6(6), 435–437 (2009).
[Crossref] [PubMed]

Liu, G.

Lopez, A. L.

Lucitti, J. L.

J. L. Lucitti, E. A. V. Jones, C. Huang, J. Chen, S. E. Fraser, and M. E. Dickinson, “Vascular remodeling of the mouse yolk sac requires hemodynamic force,” Development 134(18), 3317–3326 (2007).
[Crossref] [PubMed]

Luo, Q.

D. Zhu, K. V. Larin, Q. Luo, and V. V. Tuchin, “Recent progress in tissue optical clearing,” Laser Photonics Rev. 7(5), 732–757 (2013).
[Crossref] [PubMed]

Mancini, M.

A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
[Crossref] [PubMed]

Mauch, C. P.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Mayer, J.

McDonald, L.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

Men, J.

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
[Crossref] [PubMed]

Mickoleit, M.

M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
[Crossref] [PubMed]

Miller, J. W.

S. R. Montezuma, D. Vavvas, and J. W. Miller, “Review of the ocular angiogenesis animal models,” Semin. Ophthalmol. 24(2), 52–61 (2009).
[Crossref] [PubMed]

Montezuma, S. R.

S. R. Montezuma, D. Vavvas, and J. W. Miller, “Review of the ocular angiogenesis animal models,” Semin. Ophthalmol. 24(2), 52–61 (2009).
[Crossref] [PubMed]

Nair, A.

Nemer, G.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Nemer, M.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Nieman, B. J.

B. J. Nieman and D. H. Turnbull, “Ultrasound and Magnetic Resonance Microimaging of Mouse Development,” Methods Enzymol. 476, 379–400 (2010).
[Crossref] [PubMed]

Norden, C.

J. Icha, C. Schmied, J. Sidhaye, P. Tomancak, S. Preibisch, and C. Norden, “Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development,” J. Vis. Exp. 110, e53966 (2016).
[PubMed]

Nylk, J.

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
[Crossref] [PubMed]

Overbeek, P. A.

Pao, S. H.

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
[Crossref] [PubMed]

Piazza, V.

Piazza, V. G.

R. S. Udan, V. G. Piazza, C. W. Hsu, A. K. Hadjantonakis, and M. E. Dickinson, “Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy,” Development 141(22), 4406–4414 (2014).
[Crossref] [PubMed]

Preibisch, S.

J. Icha, C. Schmied, J. Sidhaye, P. Tomancak, S. Preibisch, and C. Norden, “Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development,” J. Vis. Exp. 110, e53966 (2016).
[PubMed]

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Qi, W.

Raghunathan, R.

Reischauer, S.

M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
[Crossref] [PubMed]

Robb, L.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

Robert-Moreno, A.

Robitaille, L.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Rollins, A. M.

M. W. Jenkins, M. Watanabe, and A. M. Rollins, “Longitudinal Imaging of Heart Development With Optical Coherence Tomography,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1166–1175 (2012).
[Crossref] [PubMed]

Rossant, J.

J. R. Walls, L. Coultas, J. Rossant, and R. M. Henkelman, “Three-dimensional analysis of vascular development in the mouse embryo,” PLoS One 3(8), e2853 (2008).
[Crossref] [PubMed]

Salvatore, M.

A. Greco, M. Mancini, S. Gargiulo, M. Gramanzini, P. P. Claudio, A. Brunetti, and M. Salvatore, “Ultrasound Biomicroscopy in Small Animal Research: Applications in Molecular and Preclinical Imaging,” J. Biomed. Biotechnol. 2012, 519238 (2012).
[Crossref] [PubMed]

Sarov, M.

R. K. Ejsmont, M. Sarov, S. Winkler, K. A. Lipinski, and P. Tomancak, “A toolkit for high-throughput, cross-species gene engineering in Drosophila,” Nat. Methods 6(6), 435–437 (2009).
[Crossref] [PubMed]

Schierloh, A.

H. U. Dodt, U. Leischner, A. Schierloh, N. Jährling, C. P. Mauch, K. Deininger, J. M. Deussing, M. Eder, W. Zieglgänsberger, and K. Becker, “Ultramicroscopy: three-dimensional visualization of neuronal networks in the whole mouse brain,” Nat. Methods 4(4), 331–336 (2007).
[Crossref] [PubMed]

Schill, A.

Schmid, B.

A. Bassi, B. Schmid, and J. Huisken, “Optical tomography complements light sheet microscopy for in toto imaging of zebrafish development,” Development 142(5), 1016–1020 (2015).
[Crossref] [PubMed]

M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
[Crossref] [PubMed]

Schmidt, A. D.

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
[Crossref] [PubMed]

Schmied, C.

J. Icha, C. Schmied, J. Sidhaye, P. Tomancak, S. Preibisch, and C. Norden, “Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development,” J. Vis. Exp. 110, e53966 (2016).
[PubMed]

Schmitt, J. P.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Schuman, J. S.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Seidman, C. E.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Seidman, J. G.

B. G. Bruneau, G. Nemer, J. P. Schmitt, F. Charron, L. Robitaille, S. Caron, D. A. Conner, M. Gessler, M. Nemer, C. E. Seidman, and J. G. Seidman, “A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease,” Cell 106(6), 709–721 (2001).
[Crossref] [PubMed]

Sharpe, J.

Sharpless, N. E.

N. E. Sharpless and R. A. Depinho, “The mighty mouse: genetically engineered mouse models in cancer drug development,” Nat. Rev. Drug Discov. 5(9), 741–754 (2006).
[Crossref] [PubMed]

Shui, B.

Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
[Crossref] [PubMed]

Sidhaye, J.

J. Icha, C. Schmied, J. Sidhaye, P. Tomancak, S. Preibisch, and C. Norden, “Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development,” J. Vis. Exp. 110, e53966 (2016).
[PubMed]

Singh, M.

Solanki, J.

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
[Crossref] [PubMed]

Stainier, D. Y.

J. Huisken and D. Y. Stainier, “Selective plane illumination microscopy techniques in developmental biology,” Development 136(12), 1963–1975 (2009).
[Crossref] [PubMed]

Stanley, E.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

Stein, J. V.

Stelzer, E. H.

P. J. Keller and E. H. Stelzer, “Quantitative in vivo imaging of entire embryos with Digital Scanned Laser Light Sheet Fluorescence Microscopy,” Curr. Opin. Neurobiol. 18(6), 624–632 (2008).
[Crossref] [PubMed]

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
[Crossref] [PubMed]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Sudheendran, N.

C. Wu, N. Sudheendran, M. Singh, I. V. Larina, M. E. Dickinson, and K. V. Larin, “Rotational imaging optical coherence tomography for full-body mouse embryonic imaging,” J. Biomed. Opt. 21(2), 026002 (2016).
[Crossref] [PubMed]

N. Sudheendran, S. Syed, M. Dickinson, I. Larina, and K. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett. 8(3), 247–252 (2011).
[Crossref]

Sun, Y. H.

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
[Crossref] [PubMed]

Supatto, W.

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

Swanson, E.

J. Fujimoto and E. Swanson, “The Development, Commercialization, and Impact of Optical Coherence Tomography,” Invest. Ophthalmol. Vis. Sci. 57(9), 1–13 (2016).
[Crossref] [PubMed]

Swanson, E. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, and C. A. Puliafito, and et, “Optical coherence tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Swoger, J.

J. Mayer, A. Robert-Moreno, R. Danuser, J. V. Stein, J. Sharpe, and J. Swoger, “OPTiSPIM: integrating optical projection tomography in light sheet microscopy extends specimen characterization to nonfluorescent contrasts,” Opt. Lett. 39(4), 1053–1056 (2014).
[Crossref] [PubMed]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[Crossref] [PubMed]

Syed, S.

N. Sudheendran, S. Syed, M. Dickinson, I. Larina, and K. Larin, “Speckle variance OCT imaging of the vasculature in live mammalian embryos,” Laser Phys. Lett. 8(3), 247–252 (2011).
[Crossref]

I. V. Larina, S. Ivers, S. Syed, M. E. Dickinson, and K. V. Larin, “Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT,” Opt. Lett. 34(7), 986–988 (2009).
[Crossref] [PubMed]

Syed, S. H.

S. H. Syed, K. V. Larin, M. E. Dickinson, and I. V. Larina, “Optical coherence tomography for high-resolution imaging of mouse development in utero,” J. Biomed. Opt. 16(4), 046004 (2011).
[Crossref] [PubMed]

Taber, L. A.

B. A. Filas, I. R. Efimov, and L. A. Taber, “Optical coherence tomography as a tool for measuring morphogenetic deformation of the looping heart,” Anat. Rec. (Hoboken) 290(9), 1057–1068 (2007).
[Crossref] [PubMed]

Tallini, Y. N.

Y. N. Tallini, B. Shui, K. S. Greene, K. Y. Deng, R. Doran, P. J. Fisher, W. Zipfel, and M. I. Kotlikoff, “BAC transgenic mice express enhanced green fluorescent protein in central and peripheral cholinergic neurons,” Physiol. Genomics 27(3), 391–397 (2006).
[Crossref] [PubMed]

Tanzi, R. E.

J. Men, Y. Huang, J. Solanki, X. Zeng, A. Alex, J. Jerwick, Z. Zhang, R. E. Tanzi, A. Li, and C. Zhou, “Optical Coherence Tomography for Brain Imaging and Developmental Biology,” IEEE J. Sel. Top. Quantum Electron. 22(4), 6803213 (2016).
[Crossref] [PubMed]

Tomancak, P.

J. Icha, C. Schmied, J. Sidhaye, P. Tomancak, S. Preibisch, and C. Norden, “Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development,” J. Vis. Exp. 110, e53966 (2016).
[PubMed]

R. K. Ejsmont, M. Sarov, S. Winkler, K. A. Lipinski, and P. Tomancak, “A toolkit for high-throughput, cross-species gene engineering in Drosophila,” Nat. Methods 6(6), 435–437 (2009).
[Crossref] [PubMed]

Truong, T. V.

T. V. Truong, W. Supatto, D. S. Koos, J. M. Choi, and S. E. Fraser, “Deep and fast live imaging with two-photon scanned light-sheet microscopy,” Nat. Methods 8(9), 757–760 (2011).
[Crossref] [PubMed]

Tsai, Y. C.

Y. S. Huang, H. Y. Ku, Y. C. Tsai, C. H. Chang, S. H. Pao, Y. H. Sun, and A. Chiou, “5D imaging via light sheet microscopy reveals cell dynamics during the eye-antenna disc primordium formation in Drosophila,” Sci. Rep. 7, 44945 (2017).
[Crossref] [PubMed]

Tuchin, V. V.

D. Zhu, K. V. Larin, Q. Luo, and V. V. Tuchin, “Recent progress in tissue optical clearing,” Laser Photonics Rev. 7(5), 732–757 (2013).
[Crossref] [PubMed]

Turnbull, D. H.

B. J. Nieman and D. H. Turnbull, “Ultrasound and Magnetic Resonance Microimaging of Mouse Development,” Methods Enzymol. 476, 379–400 (2010).
[Crossref] [PubMed]

Udan, R. S.

R. S. Udan, V. G. Piazza, C. W. Hsu, A. K. Hadjantonakis, and M. E. Dickinson, “Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy,” Development 141(22), 4406–4414 (2014).
[Crossref] [PubMed]

Vavvas, D.

S. R. Montezuma, D. Vavvas, and J. W. Miller, “Review of the ocular angiogenesis animal models,” Semin. Ophthalmol. 24(2), 52–61 (2009).
[Crossref] [PubMed]

Vedakkan, T. J.

Vettenburg, T.

T. Vettenburg, H. I. Dalgarno, J. Nylk, C. Coll-Lladó, D. E. Ferrier, T. Čižmár, F. J. Gunn-Moore, and K. Dholakia, “Light-sheet microscopy using an Airy beam,” Nat. Methods 11(5), 541–544 (2014).
[Crossref] [PubMed]

Walls, J. R.

J. R. Walls, L. Coultas, J. Rossant, and R. M. Henkelman, “Three-dimensional analysis of vascular development in the mouse embryo,” PLoS One 3(8), e2853 (2008).
[Crossref] [PubMed]

Wang, R. K.

Wang, S.

Watanabe, M.

M. W. Jenkins, M. Watanabe, and A. M. Rollins, “Longitudinal Imaging of Heart Development With Optical Coherence Tomography,” IEEE J. Sel. Top. Quantum Electron. 18(3), 1166–1175 (2012).
[Crossref] [PubMed]

Weber, M.

M. Mickoleit, B. Schmid, M. Weber, F. O. Fahrbach, S. Hombach, S. Reischauer, and J. Huisken, “High-resolution reconstruction of the beating zebrafish heart,” Nat. Methods 11(9), 919–922 (2014).
[Crossref] [PubMed]

Weber, R.

C. Biben, R. Weber, S. Kesteven, E. Stanley, L. McDonald, D. A. Elliott, L. Barnett, F. Köentgen, L. Robb, M. Feneley, and R. P. Harvey, “Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5,” Circ. Res. 87(10), 888–895 (2000).
[Crossref] [PubMed]

Winkler, S.

R. K. Ejsmont, M. Sarov, S. Winkler, K. A. Lipinski, and P. Tomancak, “A toolkit for high-throughput, cross-species gene engineering in Drosophila,” Nat. Methods 6(6), 435–437 (2009).
[Crossref] [PubMed]

Wittbrodt, J.

P. J. Keller, A. D. Schmidt, J. Wittbrodt, and E. H. Stelzer, “Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy,” Science 322(5904), 1065–1069 (2008).
[Crossref] [PubMed]

J. Huisken, J. Swoger, F. Del Bene, J. Wittbrodt, and E. H. Stelzer, “Optical sectioning deep inside live embryos by selective plane illumination microscopy,” Science 305(5686), 1007–1009 (2004).
[Crossref] [PubMed]

Wu, C.

Yu, L.

Zeng, X.

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Supplementary Material (1)

NameDescription
» Visualization 1       This media file is a 3D rendering of mouse embryo imaged by OCT and SPIM.

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Figures (4)

Fig. 1
Fig. 1

Schematic of (a) RI-OCT experimental setup and (b) SPIM setup.

Fig. 2
Fig. 2

(a) 3D OCT and (b) SPIM imaging of beads phantom. (c) Cross-sectional OCT image of selected plane. (d) Combined OCT and SPIM images of the same cross-sectional plane. Scale bars are 500 µm.

Fig. 3
Fig. 3

RI-OCT imaging of E9.5 mouse embryo at (a) 0 degree, (b) 180 degree, (c) 90 degree, (d) 270 degree, (e-h) composite from all four angles. SPIM imaging of same embryo from (i) one side, (j) opposite side, and (k-l) combined from both sides. Scale bars are 500 µm.

Fig. 4
Fig. 4

E9.5 mouse embryo. (a) 3D OCT image. (b) 3D SPIM image at an excitation wavelength of 488nm corresponding to the ϵ-globin-GFP cells (erythroblast). (c) 3D SPIM image at an excitation wavelength of 561nm for PECAM1 labeled endothelial cells. (d) 3D registered OCT and SPIM image (see Visualization 1). (e-h) 2D OCT image registered with SPIM image for various planes, and arrowhead points to the heart wall. DA: dorsal aorta, HRT: heart, EPC: ectoplacental cone, NL: neuro lumen, NVN: neuro vascular network, ISV: intersomitic vessel.

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