Abstract

To study the optical changes on hydrogel-silicone intraocular lenses (IOLs) resulting from loading them with dexamethasone. We used prototype hydrogel(pHEMA)-silicone IOLs and loaded the matrices with an anti-inflammatory drug (dexamethasone). The optical properties we analyzed experimentally were a) modulation transfer function (MTF); b) spectral transmission; c) diopter power. These determinations were performed on drug-loaded IOLs, IOLs that had released the drug, and IOLs that had not been drug-loaded. Loading a hydrogel-silicone IOL with dexamethasone results in impairment of its optical qualities, in particular its MTF and spectral transmission, but not dioptric power. However, once the drug has been released, it almost recovers its initial optical properties.

© 2017 Optical Society of America

Full Article  |  PDF Article
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References

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]

2016 (3)

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

A. Alarcon, C. Canovas, R. Rosen, H. Weeber, L. Tsai, K. Hileman, and P. Piers, “Preclinical metrics to predict through-focus visual acuity for pseudophakic patients,” Biomed. Opt. Express 7(5), 1877–1888 (2016).
[Crossref] [PubMed]

2015 (1)

M. C. García-Domene, M. A. Díez-Ajenjo, C. Peris-Martínez, A. Navea, and J. M. Artigas, “A rapid method for measuring intraocular lens power in vitro with a focimeter,” Exp. Eye Res. 140, 190–192 (2015).
[Crossref] [PubMed]

2013 (1)

Y. C. Liu, T. T. Wong, and J. S. Mehta, “Intraocular lens as a drug delivery reservoir,” Curr. Opin. Ophthalmol. 24(1), 53–59 (2013).
[Crossref] [PubMed]

2011 (6)

Y. Masmoudi, L. Ben Azzouk, O. Forzano, J. M. Andre, and E. Badens, “Supercritical impregnation of intraocular lenses,” J. Supercrit. Fluids 60, 98–105 (2011).
[Crossref]

H. Q. Bai, L. Yao, X. X. Meng, Y. X. Wang, and D. B. Wang, “Visual outcome following intraocular foreign bodies: a retrospective review of 5-year clinical experience,” Eur. J. Ophthalmol. 21(1), 98–103 (2011).
[Crossref] [PubMed]

J. M. Jefferis, U. P. Mosimann, and M. P. Clarke, “Cataract and cognitive impairment: a review of the literature,” Br. J. Ophthalmol. 95(1), 17–23 (2011).
[Crossref] [PubMed]

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

C. González-Chomón, A. Concheiro, and C. Alvarez-Lorenzo, “Drug-Eluting Intraocular Lenses,” Materials (Basel) 4(12), 1927–1940 (2011).
[Crossref]

J. M. Artigas, A. Felipe, A. Navea, C. Artigas, and M. C. García-Domene, “Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria analysis for choosing a suitable filter,” Ophthalmology 118(1), 3–8 (2011).
[Crossref] [PubMed]

2010 (3)

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

M. Kugelberg, K. Shafiei, I. van der Ploeg, and C. Zetterström, “Intraocular lens as a drug delivery system for dexamethasone,” Acta Ophthalmol. 88(2), 241–244 (2010).
[Crossref] [PubMed]

S. Manju and S. Kunnatheeri, “Layer-by-Layer modification of poly (methyl methacrylate) intra ocular lens: drug delivery applications,” Pharm. Dev. Technol. 15(4), 379–385 (2010).
[Crossref] [PubMed]

2009 (2)

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

2007 (1)

J. M. Artigas, J. L. Menezo, C. Peris, A. Felipe, and M. Díaz-Llopis, “Image quality with multifocal intraocular lenses and the effect of pupil size: comparison of refractive and hybrid refractive-diffractive designs,” J. Cataract Refract. Surg. 33(12), 2111–2117 (2007).
[Crossref] [PubMed]

2006 (1)

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

2005 (2)

T. Kawamorita and H. Uozato, “Modulation Transfer Function and pupil size in multifocal and monofocal intraocular lenses in vitro,” J. Cataract Refract. Surg. 31(12), 2379–2385 (2005).
[Crossref] [PubMed]

R. Rawer, W. Stork, C. W. Spraul, and C. Lingenfelder, “Imaging quality of intraocular lenses,” J. Cataract Refract. Surg. 31(8), 1618–1631 (2005).
[Crossref] [PubMed]

Alarcon, A.

Alvarez-Lorenzo, C.

C. González-Chomón, A. Concheiro, and C. Alvarez-Lorenzo, “Drug-Eluting Intraocular Lenses,” Materials (Basel) 4(12), 1927–1940 (2011).
[Crossref]

Anderson, E. M.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Andre, J. M.

Y. Masmoudi, L. Ben Azzouk, O. Forzano, J. M. Andre, and E. Badens, “Supercritical impregnation of intraocular lenses,” J. Supercrit. Fluids 60, 98–105 (2011).
[Crossref]

Apple, D. J.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Artigas, C.

J. M. Artigas, A. Felipe, A. Navea, C. Artigas, and M. C. García-Domene, “Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria analysis for choosing a suitable filter,” Ophthalmology 118(1), 3–8 (2011).
[Crossref] [PubMed]

Artigas, J. M.

M. C. García-Domene, M. A. Díez-Ajenjo, C. Peris-Martínez, A. Navea, and J. M. Artigas, “A rapid method for measuring intraocular lens power in vitro with a focimeter,” Exp. Eye Res. 140, 190–192 (2015).
[Crossref] [PubMed]

J. M. Artigas, A. Felipe, A. Navea, C. Artigas, and M. C. García-Domene, “Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria analysis for choosing a suitable filter,” Ophthalmology 118(1), 3–8 (2011).
[Crossref] [PubMed]

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

J. M. Artigas, J. L. Menezo, C. Peris, A. Felipe, and M. Díaz-Llopis, “Image quality with multifocal intraocular lenses and the effect of pupil size: comparison of refractive and hybrid refractive-diffractive designs,” J. Cataract Refract. Surg. 33(12), 2111–2117 (2007).
[Crossref] [PubMed]

Ascenso, J.

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

Badens, E.

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

Y. Masmoudi, L. Ben Azzouk, O. Forzano, J. M. Andre, and E. Badens, “Supercritical impregnation of intraocular lenses,” J. Supercrit. Fluids 60, 98–105 (2011).
[Crossref]

Bai, H. Q.

H. Q. Bai, L. Yao, X. X. Meng, Y. X. Wang, and D. B. Wang, “Visual outcome following intraocular foreign bodies: a retrospective review of 5-year clinical experience,” Eur. J. Ophthalmol. 21(1), 98–103 (2011).
[Crossref] [PubMed]

Ben Azzouk, L.

Y. Masmoudi, L. Ben Azzouk, O. Forzano, J. M. Andre, and E. Badens, “Supercritical impregnation of intraocular lenses,” J. Supercrit. Fluids 60, 98–105 (2011).
[Crossref]

Bouledjouidja, A.

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

Bryers, J. D.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Canovas, C.

Chew, J.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Clarke, M. P.

J. M. Jefferis, U. P. Mosimann, and M. P. Clarke, “Cataract and cognitive impairment: a review of the literature,” Br. J. Ophthalmol. 95(1), 17–23 (2011).
[Crossref] [PubMed]

Colaço, R.

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

Concheiro, A.

C. González-Chomón, A. Concheiro, and C. Alvarez-Lorenzo, “Drug-Eluting Intraocular Lenses,” Materials (Basel) 4(12), 1927–1940 (2011).
[Crossref]

Díaz-Llopis, M.

J. M. Artigas, J. L. Menezo, C. Peris, A. Felipe, and M. Díaz-Llopis, “Image quality with multifocal intraocular lenses and the effect of pupil size: comparison of refractive and hybrid refractive-diffractive designs,” J. Cataract Refract. Surg. 33(12), 2111–2117 (2007).
[Crossref] [PubMed]

Diez-Ajenjo, A.

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

Díez-Ajenjo, A.

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

Díez-Ajenjo, M. A.

M. C. García-Domene, M. A. Díez-Ajenjo, C. Peris-Martínez, A. Navea, and J. M. Artigas, “A rapid method for measuring intraocular lens power in vitro with a focimeter,” Exp. Eye Res. 140, 190–192 (2015).
[Crossref] [PubMed]

Felipe, A.

J. M. Artigas, A. Felipe, A. Navea, C. Artigas, and M. C. García-Domene, “Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria analysis for choosing a suitable filter,” Ophthalmology 118(1), 3–8 (2011).
[Crossref] [PubMed]

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

J. M. Artigas, J. L. Menezo, C. Peris, A. Felipe, and M. Díaz-Llopis, “Image quality with multifocal intraocular lenses and the effect of pupil size: comparison of refractive and hybrid refractive-diffractive designs,” J. Cataract Refract. Surg. 33(12), 2111–2117 (2007).
[Crossref] [PubMed]

Fernandes, J. C. S.

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

Forzano, O.

Y. Masmoudi, L. Ben Azzouk, O. Forzano, J. M. Andre, and E. Badens, “Supercritical impregnation of intraocular lenses,” J. Supercrit. Fluids 60, 98–105 (2011).
[Crossref]

García-Domene, M. C.

M. C. García-Domene, M. A. Díez-Ajenjo, C. Peris-Martínez, A. Navea, and J. M. Artigas, “A rapid method for measuring intraocular lens power in vitro with a focimeter,” Exp. Eye Res. 140, 190–192 (2015).
[Crossref] [PubMed]

J. M. Artigas, A. Felipe, A. Navea, C. Artigas, and M. C. García-Domene, “Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria analysis for choosing a suitable filter,” Ophthalmology 118(1), 3–8 (2011).
[Crossref] [PubMed]

Garty, S.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Gené, A.

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

González-Chomón, C.

C. González-Chomón, A. Concheiro, and C. Alvarez-Lorenzo, “Drug-Eluting Intraocular Lenses,” Materials (Basel) 4(12), 1927–1940 (2011).
[Crossref]

Hileman, K.

Hunter, B.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Jefferis, J. M.

J. M. Jefferis, U. P. Mosimann, and M. P. Clarke, “Cataract and cognitive impairment: a review of the literature,” Br. J. Ophthalmol. 95(1), 17–23 (2011).
[Crossref] [PubMed]

Kawamorita, T.

T. Kawamorita and H. Uozato, “Modulation Transfer Function and pupil size in multifocal and monofocal intraocular lenses in vitro,” J. Cataract Refract. Surg. 31(12), 2379–2385 (2005).
[Crossref] [PubMed]

Kleinmann, G.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Kugelberg, M.

M. Kugelberg, K. Shafiei, I. van der Ploeg, and C. Zetterström, “Intraocular lens as a drug delivery system for dexamethasone,” Acta Ophthalmol. 88(2), 241–244 (2010).
[Crossref] [PubMed]

Kunnatheeri, S.

S. Manju and S. Kunnatheeri, “Layer-by-Layer modification of poly (methyl methacrylate) intra ocular lens: drug delivery applications,” Pharm. Dev. Technol. 15(4), 379–385 (2010).
[Crossref] [PubMed]

Larson, S.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Lingenfelder, C.

R. Rawer, W. Stork, C. W. Spraul, and C. Lingenfelder, “Imaging quality of intraocular lenses,” J. Cataract Refract. Surg. 31(8), 1618–1631 (2005).
[Crossref] [PubMed]

Liu, Y. C.

Y. C. Liu, T. T. Wong, and J. S. Mehta, “Intraocular lens as a drug delivery reservoir,” Curr. Opin. Ophthalmol. 24(1), 53–59 (2013).
[Crossref] [PubMed]

López-Gil, N.

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

Mamalis, N.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Manju, S.

S. Manju and S. Kunnatheeri, “Layer-by-Layer modification of poly (methyl methacrylate) intra ocular lens: drug delivery applications,” Pharm. Dev. Technol. 15(4), 379–385 (2010).
[Crossref] [PubMed]

Masmoudi, Y.

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

Y. Masmoudi, L. Ben Azzouk, O. Forzano, J. M. Andre, and E. Badens, “Supercritical impregnation of intraocular lenses,” J. Supercrit. Fluids 60, 98–105 (2011).
[Crossref]

Mehta, J. S.

Y. C. Liu, T. T. Wong, and J. S. Mehta, “Intraocular lens as a drug delivery reservoir,” Curr. Opin. Ophthalmol. 24(1), 53–59 (2013).
[Crossref] [PubMed]

Menezo, J. L.

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

J. M. Artigas, J. L. Menezo, C. Peris, A. Felipe, and M. Díaz-Llopis, “Image quality with multifocal intraocular lenses and the effect of pupil size: comparison of refractive and hybrid refractive-diffractive designs,” J. Cataract Refract. Surg. 33(12), 2111–2117 (2007).
[Crossref] [PubMed]

Meng, X. X.

H. Q. Bai, L. Yao, X. X. Meng, Y. X. Wang, and D. B. Wang, “Visual outcome following intraocular foreign bodies: a retrospective review of 5-year clinical experience,” Eur. J. Ophthalmol. 21(1), 98–103 (2011).
[Crossref] [PubMed]

Meniai, A.

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

Mosimann, U. P.

J. M. Jefferis, U. P. Mosimann, and M. P. Clarke, “Cataract and cognitive impairment: a review of the literature,” Br. J. Ophthalmol. 95(1), 17–23 (2011).
[Crossref] [PubMed]

Navea, A.

M. C. García-Domene, M. A. Díez-Ajenjo, C. Peris-Martínez, A. Navea, and J. M. Artigas, “A rapid method for measuring intraocular lens power in vitro with a focimeter,” Exp. Eye Res. 140, 190–192 (2015).
[Crossref] [PubMed]

J. M. Artigas, A. Felipe, A. Navea, C. Artigas, and M. C. García-Domene, “Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria analysis for choosing a suitable filter,” Ophthalmology 118(1), 3–8 (2011).
[Crossref] [PubMed]

Noble, M. L.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Olson, R. J.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Pastor, F.

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

Peris, C.

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

J. M. Artigas, J. L. Menezo, C. Peris, A. Felipe, and M. Díaz-Llopis, “Image quality with multifocal intraocular lenses and the effect of pupil size: comparison of refractive and hybrid refractive-diffractive designs,” J. Cataract Refract. Surg. 33(12), 2111–2117 (2007).
[Crossref] [PubMed]

Peris-Martínez, C.

M. C. García-Domene, M. A. Díez-Ajenjo, C. Peris-Martínez, A. Navea, and J. M. Artigas, “A rapid method for measuring intraocular lens power in vitro with a focimeter,” Exp. Eye Res. 140, 190–192 (2015).
[Crossref] [PubMed]

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

Piers, P.

Pimenta, A. F. R.

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

Ratner, B. D.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Rawer, R.

R. Rawer, W. Stork, C. W. Spraul, and C. Lingenfelder, “Imaging quality of intraocular lenses,” J. Cataract Refract. Surg. 31(8), 1618–1631 (2005).
[Crossref] [PubMed]

Rosen, R.

Sánchez-Cortina, I.

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

Saramago, B.

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

Sergent, M.

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

Serro, A. P.

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

Shafiei, K.

M. Kugelberg, K. Shafiei, I. van der Ploeg, and C. Zetterström, “Intraocular lens as a drug delivery system for dexamethasone,” Acta Ophthalmol. 88(2), 241–244 (2010).
[Crossref] [PubMed]

Shen, T. T.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Shirakawa, R.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Spraul, C. W.

R. Rawer, W. Stork, C. W. Spraul, and C. Lingenfelder, “Imaging quality of intraocular lenses,” J. Cataract Refract. Surg. 31(8), 1618–1631 (2005).
[Crossref] [PubMed]

Stevens, S.

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

Stork, W.

R. Rawer, W. Stork, C. W. Spraul, and C. Lingenfelder, “Imaging quality of intraocular lenses,” J. Cataract Refract. Surg. 31(8), 1618–1631 (2005).
[Crossref] [PubMed]

Trivedi, V.

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

Tsai, L.

Uozato, H.

T. Kawamorita and H. Uozato, “Modulation Transfer Function and pupil size in multifocal and monofocal intraocular lenses in vitro,” J. Cataract Refract. Surg. 31(12), 2379–2385 (2005).
[Crossref] [PubMed]

van der Ploeg, I.

M. Kugelberg, K. Shafiei, I. van der Ploeg, and C. Zetterström, “Intraocular lens as a drug delivery system for dexamethasone,” Acta Ophthalmol. 88(2), 241–244 (2010).
[Crossref] [PubMed]

Wang, D. B.

H. Q. Bai, L. Yao, X. X. Meng, Y. X. Wang, and D. B. Wang, “Visual outcome following intraocular foreign bodies: a retrospective review of 5-year clinical experience,” Eur. J. Ophthalmol. 21(1), 98–103 (2011).
[Crossref] [PubMed]

Wang, Y. X.

H. Q. Bai, L. Yao, X. X. Meng, Y. X. Wang, and D. B. Wang, “Visual outcome following intraocular foreign bodies: a retrospective review of 5-year clinical experience,” Eur. J. Ophthalmol. 21(1), 98–103 (2011).
[Crossref] [PubMed]

Warsen, A.

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

Weeber, H.

Wong, T. T.

Y. C. Liu, T. T. Wong, and J. S. Mehta, “Intraocular lens as a drug delivery reservoir,” Curr. Opin. Ophthalmol. 24(1), 53–59 (2013).
[Crossref] [PubMed]

Yao, L.

H. Q. Bai, L. Yao, X. X. Meng, Y. X. Wang, and D. B. Wang, “Visual outcome following intraocular foreign bodies: a retrospective review of 5-year clinical experience,” Eur. J. Ophthalmol. 21(1), 98–103 (2011).
[Crossref] [PubMed]

Zetterström, C.

M. Kugelberg, K. Shafiei, I. van der Ploeg, and C. Zetterström, “Intraocular lens as a drug delivery system for dexamethasone,” Acta Ophthalmol. 88(2), 241–244 (2010).
[Crossref] [PubMed]

Acta Ophthalmol. (1)

M. Kugelberg, K. Shafiei, I. van der Ploeg, and C. Zetterström, “Intraocular lens as a drug delivery system for dexamethasone,” Acta Ophthalmol. 88(2), 241–244 (2010).
[Crossref] [PubMed]

Biomed. Opt. Express (1)

Br. J. Ophthalmol. (1)

J. M. Jefferis, U. P. Mosimann, and M. P. Clarke, “Cataract and cognitive impairment: a review of the literature,” Br. J. Ophthalmol. 95(1), 17–23 (2011).
[Crossref] [PubMed]

Curr. Opin. Ophthalmol. (1)

Y. C. Liu, T. T. Wong, and J. S. Mehta, “Intraocular lens as a drug delivery reservoir,” Curr. Opin. Ophthalmol. 24(1), 53–59 (2013).
[Crossref] [PubMed]

Eur. J. Ophthalmol. (1)

H. Q. Bai, L. Yao, X. X. Meng, Y. X. Wang, and D. B. Wang, “Visual outcome following intraocular foreign bodies: a retrospective review of 5-year clinical experience,” Eur. J. Ophthalmol. 21(1), 98–103 (2011).
[Crossref] [PubMed]

Exp. Eye Res. (1)

M. C. García-Domene, M. A. Díez-Ajenjo, C. Peris-Martínez, A. Navea, and J. M. Artigas, “A rapid method for measuring intraocular lens power in vitro with a focimeter,” Exp. Eye Res. 140, 190–192 (2015).
[Crossref] [PubMed]

Int. J. Pharm. (2)

A. F. R. Pimenta, J. Ascenso, J. C. S. Fernandes, R. Colaço, A. P. Serro, and B. Saramago, “Controlled drug release from hydrogels for contact lenses: Drug partitioning and diffusion,” Int. J. Pharm. 515(1-2), 467–475 (2016).
[Crossref] [PubMed]

A. Bouledjouidja, Y. Masmoudi, M. Sergent, V. Trivedi, A. Meniai, and E. Badens, “Drug loading of foldable commercial intraocular lenses using supercritical impregnation,” Int. J. Pharm. 500(1-2), 85–99 (2016).
[Crossref] [PubMed]

Invest. Ophthalmol. Vis. Sci. (1)

S. Garty, R. Shirakawa, A. Warsen, E. M. Anderson, M. L. Noble, J. D. Bryers, B. D. Ratner, and T. T. Shen, “Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery,” Invest. Ophthalmol. Vis. Sci. 52(9), 6109–6116 (2011).
[Crossref] [PubMed]

J. Cataract Refract. Surg. (7)

G. Kleinmann, D. J. Apple, J. Chew, S. Stevens, B. Hunter, S. Larson, N. Mamalis, and R. J. Olson, “Hydrophilic acrylic intraocular lens as a drug-delivery system: Pilot study,” J. Cataract Refract. Surg. 32(4), 652–654 (2006).
[Crossref] [PubMed]

J. M. Artigas, J. L. Menezo, C. Peris, A. Felipe, and M. Díaz-Llopis, “Image quality with multifocal intraocular lenses and the effect of pupil size: comparison of refractive and hybrid refractive-diffractive designs,” J. Cataract Refract. Surg. 33(12), 2111–2117 (2007).
[Crossref] [PubMed]

T. Kawamorita and H. Uozato, “Modulation Transfer Function and pupil size in multifocal and monofocal intraocular lenses in vitro,” J. Cataract Refract. Surg. 31(12), 2379–2385 (2005).
[Crossref] [PubMed]

R. Rawer, W. Stork, C. W. Spraul, and C. Lingenfelder, “Imaging quality of intraocular lenses,” J. Cataract Refract. Surg. 31(8), 1618–1631 (2005).
[Crossref] [PubMed]

J. M. Artigas, C. Peris, A. Felipe, J. L. Menezo, I. Sánchez-Cortina, and N. López-Gil, “Modulation transfer function: rigid versus foldable phakic intraocular lenses,” J. Cataract Refract. Surg. 35(4), 747–752 (2009).
[Crossref] [PubMed]

C. Peris-Martínez, J. M. Artigas, I. Sánchez-Cortina, A. Felipe, A. Díez-Ajenjo, and J. L. Menezo, “Influence of optic quality on contrast sensitivity and visual acuity in eyes with a rigid or flexible phakic intraocular lens,” J. Cataract Refract. Surg. 35(11), 1911–1917 (2009).
[Crossref] [PubMed]

A. Felipe, F. Pastor, J. M. Artigas, A. Diez-Ajenjo, A. Gené, and J. L. Menezo, “Correlation between the optical quality of intraocular lenses and patients visual acuity: tolerance to MTF decay,” J. Cataract Refract. Surg. 36, 557–562 (2010).
[Crossref] [PubMed]

J. Supercrit. Fluids (1)

Y. Masmoudi, L. Ben Azzouk, O. Forzano, J. M. Andre, and E. Badens, “Supercritical impregnation of intraocular lenses,” J. Supercrit. Fluids 60, 98–105 (2011).
[Crossref]

Materials (Basel) (1)

C. González-Chomón, A. Concheiro, and C. Alvarez-Lorenzo, “Drug-Eluting Intraocular Lenses,” Materials (Basel) 4(12), 1927–1940 (2011).
[Crossref]

Ophthalmology (1)

J. M. Artigas, A. Felipe, A. Navea, C. Artigas, and M. C. García-Domene, “Spectral transmittance of intraocular lenses under natural and artificial illumination: criteria analysis for choosing a suitable filter,” Ophthalmology 118(1), 3–8 (2011).
[Crossref] [PubMed]

Pharm. Dev. Technol. (1)

S. Manju and S. Kunnatheeri, “Layer-by-Layer modification of poly (methyl methacrylate) intra ocular lens: drug delivery applications,” Pharm. Dev. Technol. 15(4), 379–385 (2010).
[Crossref] [PubMed]

Other (3)

EN/ISO 11979–2: Ophthalmic Implants –Intraocular Lenses- Part 2: Optical Properties and Test Methods, Geneva, International Organization for Standardization (2014).

EN/ISO 9334: Optical Instruments- Optical Transfer Function- Definitions and Mathematical Relationships, Geneva, International Organization for Standardization (2002).

EN/ISO 9335: Optical Instruments- Optical Transfer Function- Principles and Procedures of Measurements, Geneva, International Organization for Standardization (2002).

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Figures (3)

Fig. 1
Fig. 1 Cross Line Spread Function (LSF) of a dexamethasone-loaded IOL (left), LSF of a dexamethasone-loaded IOL that had subsequently released this drug (center), compared with the LSF of a similar, but non-treated IOL (right).
Fig. 2
Fig. 2 MTF of a dexamethasone-loaded IOL, and MTF of a dexamethasone-loaded IOL that had subsequently released this drug, for a 3 mm pupil compared with the MTF of a similar, but non-treated IOL. Mean of three lenses.
Fig. 3
Fig. 3 Spectral transmission of drug-loaded, dexamethasone-released, and non-treated IOLs. Mean of three lenses.

Tables (1)

Tables Icon

Table 1 MTF value for drug-loaded, drug-released, and non-treated IOLs for a spatial frequency of 100 c/mm (MTF_100). Strehl Ratio (SR) value. Average Modulation (AM) value. Standard Deviation (SD). All the values for 3 mm pupils. IOL power in diopters (IOL Power).

Metrics