Abstract

Reflection artifacts caused by acoustic inhomogeneities are a critical problem in epi-mode biomedical photoacoustic imaging. High light fluence beneath the probe results in photoacoustic transients, which propagate into the tissue and reflect back from echogenic structures. These reflection artifacts cause problems in image interpretation and significantly impact the contrast and imaging depth. We recently proposed a method called PAFUSion (Photoacoustic-guided focused ultrasound) to identify such reflection artifacts in photoacoustic imaging. In its initial version, PAFUSion mimics the inward-travelling wavefield from small blood vessel-like PA sources by applying ultrasound pulses focused towards these sources, and thus provides a way to identify the resulting reflection artifacts. In this work, we demonstrate reduction of reflection artifacts in phantoms and in vivo measurements on human volunteers. In view of the spatially distributed PA sources that are found in clinical applications, we implemented an improved version of PAFUSion where photoacoustic signals are backpropagated to imitate the inward travelling wavefield and thus the reflection artifacts. The backpropagation is performed in a synthetic way based on the pulse-echo acquisitions after transmission on each single element of the transducer array. The results provide a direct confirmation that reflection artifacts are prominent in clinical epi-photoacoustic imaging, and that PAFUSion can strongly reduce these artifacts to improve deep-tissue photoacoustic imaging.

© 2016 Optical Society of America

Full Article  |  PDF Article
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References

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    [Crossref] [PubMed]

2016 (2)

2015 (4)

M. Kuniyil Ajith Singh and W. Steenbergen, “Photoacoustic-guided focused ultrasound (PAFUSion) for identifying reflection artifacts in photoacoustic imaging,” Photoacoustics 3(4), 123–131 (2015).
[Crossref]

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

L. Xi and H. B. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107, 063701 (2015).

2014 (7)

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

X. L. Dean-Ben and D. Razansky, “Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography,” Light Sci. Appl. 3, e137 (2014).

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

M. A. Lediju Bell, N. P. Kuo, D. Y. Song, J. U. Kang, and E. M. Boctor, “In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging,” J. Biomed. Opt. 19(12), 126011 (2014).
[Crossref] [PubMed]

T. F. Fehm, X. L. Dean-Ben, and D. Razansky, “Four dimensional hybrid ultrasound and optoacoustic imaging via passive element optical excitation in a hand-held probe,” Appl. Phys. Lett. 105(17), 173505 (2014).
[Crossref]

G. Held, S. Preisser, H. G. Akarçay, S. Peeters, M. Frenz, and M. Jaeger, “Effect of irradiation distance on image contrast in epi-optoacoustic imaging of human volunteers,” Biomed. Opt. Express 5(11), 3765–3780 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

2013 (3)

D. Piras, C. Grijsen, P. Schütte, W. Steenbergen, and S. Manohar, “Photoacoustic needle: minimally invasive guidance to biopsy,” J. Biomed. Opt. 18(7), 070502 (2013).
[Crossref] [PubMed]

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

M. Jaeger, J. C. Bamber, and M. Frenz, “Clutter elimination for deep clinical optoacoustic imaging using localised vibration tagging (LOVIT),” Photoacoustics 1(2), 19–29 (2013).
[Crossref] [PubMed]

2012 (3)

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, and J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[Crossref] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[Crossref] [PubMed]

2011 (3)

C. L. Bayer, Y. S. Chen, S. Kim, S. Mallidi, K. Sokolov, and S. Emelianov, “Multiplex photoacoustic molecular imaging using targeted silica-coated gold nanorods,” Biomed. Opt. Express 2(7), 1828–1835 (2011).
[Crossref] [PubMed]

D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber,” J. Biomed. Opt. 16(2), 026012 (2011).
[Crossref] [PubMed]

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

2010 (2)

2009 (3)

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

M. Jaeger, L. Siegenthaler, M. Kitz, and M. Frenz, “Reduction of background in optoacoustic image sequences obtained under tissue deformation,” J. Biomed. Opt. 14(5), 054011 (2009).
[Crossref] [PubMed]

2008 (1)

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[Crossref] [PubMed]

2007 (1)

M. Jaeger, S. Schupbach, A. Gertsch, M. Kitz, and M. Frenz, “Fourier reconstruction in optoacoustic imaging using truncated regularized inverse k-space interpolation,” Inverse Probl. 23(6), S51–S63 (2007).
[Crossref]

2006 (2)

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77, 041101 (2006).

2005 (1)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Aguirre, A.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

Akarçay, H. G.

Bamber, J.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, and J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[Crossref] [PubMed]

Bamber, J. C.

M. Jaeger, J. C. Bamber, and M. Frenz, “Clutter elimination for deep clinical optoacoustic imaging using localised vibration tagging (LOVIT),” Photoacoustics 1(2), 19–29 (2013).
[Crossref] [PubMed]

Bates, D.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Bauer, D. R.

D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber,” J. Biomed. Opt. 16(2), 026012 (2011).
[Crossref] [PubMed]

Bay, E.

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

Bayer, C. L.

Beard, P.

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

Beard, P. C.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Beckmann, M. F.

Bernelot Moens, H. J.

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

Biswas, S. K.

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

Boctor, E. M.

M. A. Lediju Bell, N. P. Kuo, D. Y. Song, J. U. Kang, and E. M. Boctor, “In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging,” J. Biomed. Opt. 19(12), 126011 (2014).
[Crossref] [PubMed]

Brands, P.

Brands, P. J.

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[Crossref] [PubMed]

Brewer, M.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

Brinkhuis, M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Carson, P. L.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

Chen, Y. S.

Conjusteau, A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Daoudi, K.

David, A. L.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Dean-Ben, X. L.

X. L. Dean-Ben and D. Razansky, “Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography,” Light Sci. Appl. 3, e137 (2014).

T. F. Fehm, X. L. Dean-Ben, and D. Razansky, “Four dimensional hybrid ultrasound and optoacoustic imaging via passive element optical excitation in a hand-held probe,” Appl. Phys. Lett. 105(17), 173505 (2014).
[Crossref]

Deán-Ben, X. L.

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[Crossref] [PubMed]

Desjardins, A. E.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Emelianov, S.

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Erpelding, T. N.

Fehm, T. F.

T. F. Fehm, X. L. Dean-Ben, and D. Razansky, “Four dimensional hybrid ultrasound and optoacoustic imaging via passive element optical excitation in a hand-held probe,” Appl. Phys. Lett. 105(17), 173505 (2014).
[Crossref]

Foster, F. S.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Fowlkes, J. B.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

Frenz, M.

G. Held, S. Preisser, H. G. Akarçay, S. Peeters, M. Frenz, and M. Jaeger, “Effect of irradiation distance on image contrast in epi-optoacoustic imaging of human volunteers,” Biomed. Opt. Express 5(11), 3765–3780 (2014).
[Crossref] [PubMed]

M. Jaeger, J. C. Bamber, and M. Frenz, “Clutter elimination for deep clinical optoacoustic imaging using localised vibration tagging (LOVIT),” Photoacoustics 1(2), 19–29 (2013).
[Crossref] [PubMed]

M. Jaeger, L. Siegenthaler, M. Kitz, and M. Frenz, “Reduction of background in optoacoustic image sequences obtained under tissue deformation,” J. Biomed. Opt. 14(5), 054011 (2009).
[Crossref] [PubMed]

M. Jaeger, S. Schupbach, A. Gertsch, M. Kitz, and M. Frenz, “Fourier reconstruction in optoacoustic imaging using truncated regularized inverse k-space interpolation,” Inverse Probl. 23(6), S51–S63 (2007).
[Crossref]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Gamelin, J.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

Gertsch, A.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, and J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[Crossref] [PubMed]

M. Jaeger, S. Schupbach, A. Gertsch, M. Kitz, and M. Frenz, “Fourier reconstruction in optoacoustic imaging using truncated regularized inverse k-space interpolation,” Inverse Probl. 23(6), S51–S63 (2007).
[Crossref]

Girish, G.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

Grijsen, C.

D. Piras, C. Grijsen, P. Schütte, W. Steenbergen, and S. Manohar, “Photoacoustic needle: minimally invasive guidance to biopsy,” J. Biomed. Opt. 18(7), 070502 (2013).
[Crossref] [PubMed]

Guo, P.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

Harris-Birtill, D.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, and J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[Crossref] [PubMed]

Heijblom, M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Heinmiller, A.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Held, G.

Hirson, D.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Hondebrink, E.

Hu, S.

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt. 15(1), 011101 (2010).
[Crossref] [PubMed]

Hussain, A.

Jaeger, M.

G. Held, S. Preisser, H. G. Akarçay, S. Peeters, M. Frenz, and M. Jaeger, “Effect of irradiation distance on image contrast in epi-optoacoustic imaging of human volunteers,” Biomed. Opt. Express 5(11), 3765–3780 (2014).
[Crossref] [PubMed]

M. Jaeger, J. C. Bamber, and M. Frenz, “Clutter elimination for deep clinical optoacoustic imaging using localised vibration tagging (LOVIT),” Photoacoustics 1(2), 19–29 (2013).
[Crossref] [PubMed]

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, and J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[Crossref] [PubMed]

M. Jaeger, L. Siegenthaler, M. Kitz, and M. Frenz, “Reduction of background in optoacoustic image sequences obtained under tissue deformation,” J. Biomed. Opt. 14(5), 054011 (2009).
[Crossref] [PubMed]

M. Jaeger, S. Schupbach, A. Gertsch, M. Kitz, and M. Frenz, “Fourier reconstruction in optoacoustic imaging using truncated regularized inverse k-space interpolation,” Inverse Probl. 23(6), S51–S63 (2007).
[Crossref]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Jankovic, L.

Jiang, H. B.

L. Xi and H. B. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107, 063701 (2015).

Kang, J. U.

M. A. Lediju Bell, N. P. Kuo, D. Y. Song, J. U. Kang, and E. M. Boctor, “In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging,” J. Biomed. Opt. 19(12), 126011 (2014).
[Crossref] [PubMed]

Kaplan, M. J.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Kim, C.

Kim, S.

Kitz, M.

M. Jaeger, L. Siegenthaler, M. Kitz, and M. Frenz, “Reduction of background in optoacoustic image sequences obtained under tissue deformation,” J. Biomed. Opt. 14(5), 054011 (2009).
[Crossref] [PubMed]

M. Jaeger, S. Schupbach, A. Gertsch, M. Kitz, and M. Frenz, “Fourier reconstruction in optoacoustic imaging using truncated regularized inverse k-space interpolation,” Inverse Probl. 23(6), S51–S63 (2007).
[Crossref]

Klaase, J. M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

Kohl, A.

Kolkman, R. G. M.

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[Crossref] [PubMed]

Kuniyil Ajith Singh, M.

M. Kuniyil Ajith Singh and W. Steenbergen, “Photoacoustic-guided focused ultrasound (PAFUSion) for identifying reflection artifacts in photoacoustic imaging,” Photoacoustics 3(4), 123–131 (2015).
[Crossref]

Kuo, N. P.

M. A. Lediju Bell, N. P. Kuo, D. Y. Song, J. U. Kang, and E. M. Boctor, “In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging,” J. Biomed. Opt. 19(12), 126011 (2014).
[Crossref] [PubMed]

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Lediju Bell, M. A.

M. A. Lediju Bell, N. P. Kuo, D. Y. Song, J. U. Kang, and E. M. Boctor, “In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging,” J. Biomed. Opt. 19(12), 126011 (2014).
[Crossref] [PubMed]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Mallidi, S.

Manohar, S.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

D. Piras, C. Grijsen, P. Schütte, W. Steenbergen, and S. Manohar, “Photoacoustic needle: minimally invasive guidance to biopsy,” J. Biomed. Opt. 18(7), 070502 (2013).
[Crossref] [PubMed]

Mari, J. M.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Maslov, K.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Montilla, L. G.

D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber,” J. Biomed. Opt. 16(2), 026012 (2011).
[Crossref] [PubMed]

Needles, A.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Nikitichev, D. I.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Ntziachristos, V.

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[Crossref] [PubMed]

O’Flynn, E.

M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, and J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
[Crossref] [PubMed]

Olafsson, R.

D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber,” J. Biomed. Opt. 16(2), 026012 (2011).
[Crossref] [PubMed]

Oraevsky, A. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Ourselin, S.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Pashley, M. D.

Peeters, S.

Petersen, W.

Piras, D.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

D. Piras, C. Grijsen, P. Schütte, W. Steenbergen, and S. Manohar, “Photoacoustic needle: minimally invasive guidance to biopsy,” J. Biomed. Opt. 18(7), 070502 (2013).
[Crossref] [PubMed]

Pratt, R.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Preisser, S.

Rabot, O.

Rajian, J. R.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

Razansky, D.

X. L. Dean-Ben and D. Razansky, “Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography,” Light Sci. Appl. 3, e137 (2014).

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

T. F. Fehm, X. L. Dean-Ben, and D. Razansky, “Four dimensional hybrid ultrasound and optoacoustic imaging via passive element optical excitation in a hand-held probe,” Appl. Phys. Lett. 105(17), 173505 (2014).
[Crossref]

X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
[Crossref] [PubMed]

Sanders, M. M.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

Schmitz, G.

Schupbach, S.

M. Jaeger, S. Schupbach, A. Gertsch, M. Kitz, and M. Frenz, “Fourier reconstruction in optoacoustic imaging using truncated regularized inverse k-space interpolation,” Inverse Probl. 23(6), S51–S63 (2007).
[Crossref]

Schütte, P.

D. Piras, C. Grijsen, P. Schütte, W. Steenbergen, and S. Manohar, “Photoacoustic needle: minimally invasive guidance to biopsy,” J. Biomed. Opt. 18(7), 070502 (2013).
[Crossref] [PubMed]

Schwab, H. M.

Siegenthaler, L.

M. Jaeger, L. Siegenthaler, M. Kitz, and M. Frenz, “Reduction of background in optoacoustic image sequences obtained under tissue deformation,” J. Biomed. Opt. 14(5), 054011 (2009).
[Crossref] [PubMed]

Sokolov, K.

Song, D. Y.

M. A. Lediju Bell, N. P. Kuo, D. Y. Song, J. U. Kang, and E. M. Boctor, “In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging,” J. Biomed. Opt. 19(12), 126011 (2014).
[Crossref] [PubMed]

Staley, J.

Steenbergen, W.

A. Hussain, W. Petersen, J. Staley, E. Hondebrink, and W. Steenbergen, “Quantitative blood oxygen saturation imaging using combined photoacoustics and acousto-optics,” Opt. Lett. 41(8), 1720–1723 (2016).
[Crossref] [PubMed]

M. Kuniyil Ajith Singh and W. Steenbergen, “Photoacoustic-guided focused ultrasound (PAFUSion) for identifying reflection artifacts in photoacoustic imaging,” Photoacoustics 3(4), 123–131 (2015).
[Crossref]

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

D. Piras, C. Grijsen, P. Schütte, W. Steenbergen, and S. Manohar, “Photoacoustic needle: minimally invasive guidance to biopsy,” J. Biomed. Opt. 18(7), 070502 (2013).
[Crossref] [PubMed]

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[Crossref] [PubMed]

Stoica, G.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

Sun, J.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Theodoropoulos, C.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Tisserand, S.

van den Berg, P. J.

van den Engh, F. M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

van der Schaaf, M.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

van Es, P.

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

van Hespen, J. C. G.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

van Leeuwen, T. G.

M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
[Crossref] [PubMed]

R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[Crossref] [PubMed]

Wang, L. V.

S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt. 15(1), 011101 (2010).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, L. Jankovic, M. D. Pashley, and L. V. Wang, “Deeply penetrating in vivo photoacoustic imaging using a clinical ultrasound array system,” Biomed. Opt. Express 1(1), 278–284 (2010).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77, 041101 (2006).

Wang, X.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

West, S. J.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

Witte, R. S.

D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber,” J. Biomed. Opt. 16(2), 026012 (2011).
[Crossref] [PubMed]

Xi, L.

L. Xi and H. B. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107, 063701 (2015).

Xia, W.

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
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Xu, G.

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

Xu, M.

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77, 041101 (2006).

Yan, S.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
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Yin, M.

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
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Zhang, H. F.

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

Zhu, Q.

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

Appl. Phys. Lett. (2)

L. Xi and H. B. Jiang, “High resolution three-dimensional photoacoustic imaging of human finger joints in vivo,” Appl. Phys. Lett. 107, 063701 (2015).

T. F. Fehm, X. L. Dean-Ben, and D. Razansky, “Four dimensional hybrid ultrasound and optoacoustic imaging via passive element optical excitation in a hand-held probe,” Appl. Phys. Lett. 105(17), 173505 (2014).
[Crossref]

Biomed. Opt. Express (4)

IEEE Trans. Med. Imaging (1)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (1)

A. Needles, A. Heinmiller, J. Sun, C. Theodoropoulos, D. Bates, D. Hirson, M. Yin, and F. S. Foster, “Development and Initial Application of a Fully Integrated Photoacoustic Micro-Ultrasound System,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 60(5), 888–897 (2013).
[Crossref] [PubMed]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

Inverse Probl. (1)

M. Jaeger, S. Schupbach, A. Gertsch, M. Kitz, and M. Frenz, “Fourier reconstruction in optoacoustic imaging using truncated regularized inverse k-space interpolation,” Inverse Probl. 23(6), S51–S63 (2007).
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J. Biomed. Opt. (13)

D. Piras, C. Grijsen, P. Schütte, W. Steenbergen, and S. Manohar, “Photoacoustic needle: minimally invasive guidance to biopsy,” J. Biomed. Opt. 18(7), 070502 (2013).
[Crossref] [PubMed]

W. Xia, D. I. Nikitichev, J. M. Mari, S. J. West, R. Pratt, A. L. David, S. Ourselin, P. C. Beard, and A. E. Desjardins, “Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures,” J. Biomed. Opt. 20(8), 086005 (2015).
[Crossref] [PubMed]

M. A. Lediju Bell, N. P. Kuo, D. Y. Song, J. U. Kang, and E. M. Boctor, “In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging,” J. Biomed. Opt. 19(12), 126011 (2014).
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M. Jaeger, D. Harris-Birtill, A. Gertsch, E. O’Flynn, and J. Bamber, “Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo,” J. Biomed. Opt. 17(6), 066007 (2012).
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X. L. Deán-Ben, V. Ntziachristos, and D. Razansky, “Artefact reduction in optoacoustic tomographic imaging by estimating the distribution of acoustic scatterers,” J. Biomed. Opt. 17(11), 110504 (2012).
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S. Hu and L. V. Wang, “Photoacoustic imaging and characterization of the microvasculature,” J. Biomed. Opt. 15(1), 011101 (2010).
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S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
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R. G. M. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008).
[Crossref] [PubMed]

A. Aguirre, P. Guo, J. Gamelin, S. Yan, M. M. Sanders, M. Brewer, and Q. Zhu, “Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization,” J. Biomed. Opt. 14(5), 054014 (2009).
[Crossref] [PubMed]

M. Jaeger, L. Siegenthaler, M. Kitz, and M. Frenz, “Reduction of background in optoacoustic image sequences obtained under tissue deformation,” J. Biomed. Opt. 14(5), 054011 (2009).
[Crossref] [PubMed]

G. Xu, J. R. Rajian, G. Girish, M. J. Kaplan, J. B. Fowlkes, P. L. Carson, and X. Wang, “Photoacoustic and ultrasound dual-modality imaging of human peripheral joints,” J. Biomed. Opt. 18(1), 010502 (2012).
[Crossref] [PubMed]

D. R. Bauer, R. Olafsson, L. G. Montilla, and R. S. Witte, “3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber,” J. Biomed. Opt. 16(2), 026012 (2011).
[Crossref] [PubMed]

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
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Light Sci. Appl. (1)

X. L. Dean-Ben and D. Razansky, “Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography,” Light Sci. Appl. 3, e137 (2014).

Nat. Biotechnol. (1)

H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24(7), 848–851 (2006).
[Crossref] [PubMed]

Opt. Express (1)

Opt. Lett. (1)

Photoacoustics (2)

M. Jaeger, J. C. Bamber, and M. Frenz, “Clutter elimination for deep clinical optoacoustic imaging using localised vibration tagging (LOVIT),” Photoacoustics 1(2), 19–29 (2013).
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M. Kuniyil Ajith Singh and W. Steenbergen, “Photoacoustic-guided focused ultrasound (PAFUSion) for identifying reflection artifacts in photoacoustic imaging,” Photoacoustics 3(4), 123–131 (2015).
[Crossref]

Rev. Sci. Instrum. (1)

M. Xu and L. V. Wang, “Photoacoustic imaging in biomedicine,” Rev. Sci. Instrum. 77, 041101 (2006).

Sci. Rep. (2)

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
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M. Heijblom, D. Piras, M. Brinkhuis, J. C. G. van Hespen, F. M. van den Engh, M. van der Schaaf, J. M. Klaase, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology,” Sci. Rep. 5, 11778 (2015).
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Other (3)

X. Wang, J. Jo, G. Xu, A. Marquardt, S. Francis, G. Gandikota, and J. Yuan, “Photoacoustic imaging of human inflammatory arthritis,” in proceedings of IEEE International Ultrasonics Symposium (IUS, 2015), pp. 1–4.
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M. Kuniyil Ajith Singh, W. Steenbergen, and S. Manohar, “Handheld Probe-Based Dual Mode Ultrasound/Photoacoustics for Biomedical Imaging,” in Frontiers in Biophotonics for Translational Medicine, M. Olivo and U. S. Dinish, eds. (Springer Singapore, 2016), pp. 209–247.

E. J. Alles, M. Jaeger, and J. C. Bamber, “Photoacoustic Clutter Reduction Using Short-Lag Spatial Coherence Weighted Imaging,” in proceedings of IEEE International Ultrasonics Symposium (IUS, 2014), pp. 41–44.
[Crossref]

Supplementary Material (2)

NameDescription
» Visualization 1: AVI (1560 KB)      In vivo measurement 1: The initial photoacoustic image followed by the corrected photoacoustic image after subtraction of the PAFUSion image.
» Visualization 2: AVI (1402 KB)      In vivo measurement 2: The initial photoacoustic image followed by the corrected photoacoustic image after subtraction of the PAFUSion image.

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Figures (7)

Fig. 1
Fig. 1

(a) Illustration of inward (Pi) and outward-propagating (PO) PA transients, for the special case where they are generated by optical absorption in the skin melanin layer. (b) Time-inversion and backpropagation of the PA signal from interval t = [0, T], towards (c) mimicking the inward-travelling wavefield Pi* and identification of resulting echoes.

Fig. 2
Fig. 2

Illustration of the experimental setup.

Fig. 3
Fig. 3

Scheme of the phantom and experimental setup.

Fig. 4
Fig. 4

Epi-mode PA/US setup used for the in vivo measurements.

Fig. 5
Fig. 5

Phantom experiment a) photoacoustic image, b) ultrasound image, c) PAFUSion image with identified reflection artifacts, d) corrected photoacoustic image.

Fig. 6
Fig. 6

In vivo measurement 1 a) photoacoustic image, b) ultrasound image, c) PAFUSion image with identified reflection artifacts, d) corrected photoacoustic image after subtraction of reflection artifacts, e) photoacoustic image with features marked for reference. The initial photoacoustic image followed by the corrected photoacoustic image after subtraction of the PAFUSion image is shown in Visualization 1.

Fig. 7
Fig. 7

In vivo measurement 2 a) photoacoustic image, b) ultrasound image, c) PAFUSion image with identified reflection artifacts, d) corrected photoacoustic image, e) photoacoustic image with features marked for reference. The initial photoacoustic image followed by the corrected photoacoustic image after subtraction of the PAFUSion image is shown in Visualization 2.

Tables (2)

Tables Icon

Table 1 Intensity reduction ratio of all the marked regions in the PA image for in vivo measurement 1.

Tables Icon

Table 2 Intensity reduction ratio of all the marked regions in the PA image for in vivo measurement 2.

Equations (8)

Equations on this page are rendered with MathJax. Learn more.

P i ( r,t )= P O ( r,t ),
S( n,t )= P O ( r n ,t )+H( r,tn,t ) P i ( r,t ).
P O '( r,t' )= P O ( r,Tt' ).
P i * ( r, t * ) P O '( r, t * +T )= P O ( r,T t * T )= P O ( r, t * )= P i ( r, t * ).
S * ( n, t * )=H P i * ( r, t * )=H P i ( r,t= t * ),
S( n,t ) S * ( n, t * =t )= P O ( r n ,t )+H[ P i ( r,t ) P i * ( r, t * =t ) ]= P O ( r n ,t ).
P i * ( r, t * )= n P i,n * ( r,t''= t * +T ) = n 0 T dt'S( n,Tt' ) P δ,n ( r,t''t' ) .
S * ( n * , t * )= n S * n ( n * ,t''= t * +T ) = n 0 T dt'S( n,Tt' )[ H* P δ,n ]( n * ,t''t' ) n 0 T dt'S( n,Tt' ) S δ,n ( n * ,t''t' ) .

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