Abstract

A scanning system for small animal imaging using non-contact, hybrid broadband diffuse optical spectroscopy (ncDOS) and diffuse correlation spectroscopy (ncDCS) is presented. The ncDOS uses a two-dimensional spectrophotometer retrieving broadband (610-900 nm) spectral information from up to fifty-seven source-detector distances between 2 and 5 mm. The ncDCS data is simultaneously acquired from four source-detector pairs. The sample is scanned in two dimensions while tracking variations in height. The system has been validated with liquid phantoms, demonstrated in vivo on a human fingertip during an arm cuff occlusion and on a group of mice with xenoimplanted renal cell carcinoma.

© 2016 Optical Society of America

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  86. R. Cheung, M. Solonenko, T. M. Busch, F. Del Piero, M. E. Putt, S. M. Hahn, and A. G. Yodh, “Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model,” J. Biomed. Opt. 8(2), 248–252 (2003).
    [Crossref] [PubMed]
  87. J. C. Finlay, D. L. Conover, E. L. Hull, and T. H. Foster, “Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo,” Photochem. Photobiol. 73(1), 54–63 (2001).
    [Crossref] [PubMed]

2015 (7)

E. M. Buckley, S. D. Patel, B. F. Miller, M. A. Franceschini, and S. J. Vannucci, “In vivo Monitoring of Cerebral Hemodynamics in the Immature Rat: Effects of Hypoxia-Ischemia and Hypothermia,” Dev. Neurosci. 37(4-5), 407–416 (2015).
[Crossref] [PubMed]

E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

L. He, Y. Lin, C. Huang, D. Irwin, M. M. Szabunio, and G. Yu, “Noncontact diffuse correlation tomography of human breast tumor,” J. Biomed. Opt. 20(8), 086003 (2015).
[Crossref] [PubMed]

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
[Crossref] [PubMed]

S. Han, J. Johansson, M. Mireles, A. R. Proctor, M. D. Hoffman, J. B. Vella, D. S. Benoit, T. Durduran, and R. Choe, “Non-contact scanning diffuse correlation tomography system for three-dimensional blood flow imaging in a murine bone graft model,” Biomed. Opt. Express 6(7), 2695–2712 (2015).
[Crossref] [PubMed]

M. Diop, J. Kishimoto, V. Toronov, D. S. Lee, and K. St Lawrence, “Development of a combined broadband near-infrared and diffusion correlation system for monitoring cerebral blood flow and oxidative metabolism in preterm infants,” Biomed. Opt. Express 6(10), 3907–3918 (2015).
[Crossref] [PubMed]

C. Huang, Y. Lin, L. He, D. Irwin, M. M. Szabunio, and G. Yu, “Alignment of sources and detectors on breast surface for noncontact diffuse correlation tomography of breast tumors,” Appl. Opt. 54(29), 8808–8816 (2015).
[Crossref] [PubMed]

2014 (2)

Y. Lin, C. Huang, D. Irwin, L. He, Y. Shang, and G. Yu, “Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography,” Appl. Phys. Lett. 104(12), 121103 (2014).
[Crossref] [PubMed]

J. Selb, D. A. Boas, S. T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

2013 (2)

T. Li, Y. Lin, Y. Shang, L. He, C. Huang, M. Szabunio, and G. Yu, “Simultaneous measurement of deep tissue blood flow and oxygenation using noncontact diffuse correlation spectroscopy flow-oximeter,” Sci. Rep. 3, 1358 (2013).
[Crossref] [PubMed]

R. Cheng, X. Zhang, A. Daugherty, H. Shin, and G. Yu, “Noninvasive quantification of postocclusive reactive hyperemia in mouse thigh muscle by near-infrared diffuse correlation spectroscopy,” Appl. Opt. 52(30), 7324–7330 (2013).
[Crossref] [PubMed]

2012 (3)

R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
[Crossref] [PubMed]

H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
[Crossref] [PubMed]

T. M. Baran, J. D. Wilson, S. Mitra, J. L. Yao, E. M. Messing, D. L. Waldman, and T. H. Foster, “Optical property measurements establish the feasibility of photodynamic therapy as a minimally invasive intervention for tumors of the kidney,” J. Biomed. Opt. 17(9), 098002 (2012).
[Crossref] [PubMed]

2011 (6)

D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
[Crossref] [PubMed]

F. Foschum, M. Jäger, and A. Kienle, “Fully automated spatially resolved reflectance spectrometer for the determination of the absorption and scattering in turbid media,” Rev. Sci. Instrum. 82(10), 103104 (2011).
[Crossref] [PubMed]

R. T. Kester, N. Bedard, L. Gao, and T. S. Tkaczyk, “Real-time snapshot hyperspectral imaging endoscope,” J. Biomed. Opt. 16(5), 056005 (2011).
[Crossref] [PubMed]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
[Crossref] [PubMed]

T. L. Becker, A. D. Paquette, K. R. Keymel, B. W. Henderson, and U. Sunar, “Monitoring blood flow responses during topical ALA-PDT,” Biomed. Opt. Express 2(1), 123–130 (2011).
[Crossref] [PubMed]

F. Larusson, S. Fantini, and E. L. Miller, “Hyperspectral image reconstruction for diffuse optical tomography,” Biomed. Opt. Express 2(4), 946–965 (2011).
[Crossref] [PubMed]

2010 (5)

H. Cen and R. Lu, “Optimization of the hyperspectral imaging-based spatially-resolved system for measuring the optical properties of biological materials,” Opt. Express 18(16), 17412–17432 (2010).
[Crossref] [PubMed]

R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
[Crossref] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

2009 (5)

T. M. Busch, X. Xing, G. Yu, A. Yodh, E. P. Wileyto, H. W. Wang, T. Durduran, T. C. Zhu, and K. K. Wang, “Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy,” Photochem. Photobiol. Sci. 8, 1683–1693 (2009).

S. R. Arridge and J. C. Schotland, “Optical tomography: forward and inverse problems,” Inverse Probl. 25(12), 123010 (2009).
[Crossref]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

H. W. Wang, J. K. Jiang, C. H. Lin, J. K. Lin, G. J. Huang, and J. S. Yu, “Diffuse reflectance spectroscopy detects increased hemoglobin concentration and decreased oxygenation during colon carcinogenesis from normal to malignant tumors,” Opt. Express 17(4), 2805–2817 (2009).
[Crossref] [PubMed]

2008 (1)

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: a systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

2007 (7)

J. J. Xia, E. P. Berg, J. W. Lee, and G. Yao, “Characterizing beef muscles with optical scattering and absorption coefficients in VIS-NIR region,” Meat Sci. 75(1), 78–83 (2007).
[Crossref] [PubMed]

P. Taroni, D. Comelli, A. Pifferi, A. Torricelli, and R. Cubeddu, “Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications,” J. Biomed. Opt. 12(1), 014021 (2007).
[Crossref] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[Crossref] [PubMed]

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

S. V. Panasyuk, S. Yang, D. V. Faller, D. Ngo, R. A. Lew, J. E. Freeman, and A. E. Rogers, “Medical hyperspectral imaging to facilitate residual tumor identification during surgery,” Cancer Biol. Ther. 6(3), 439–446 (2007).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

2006 (4)

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[Crossref] [PubMed]

Y. Zong, S. W. Brown, B. C. Johnson, K. R. Lykke, and Y. Ohno, “Simple spectral stray light correction method for array spectroradiometers,” Appl. Opt. 45(6), 1111–1119 (2006).
[Crossref] [PubMed]

R. F. Lu and Y. K. Peng, “Hyperspectral scattering for assessing peach fruit firmness,” Biosystems Eng. 93(2), 161–171 (2006).
[Crossref]

C. Zhu, G. M. Palmer, T. M. Breslin, J. Harter, and N. Ramanujam, “Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique,” Lasers Surg. Med. 38(7), 714–724 (2006).
[Crossref] [PubMed]

2005 (6)

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[Crossref] [PubMed]

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

A. N. Bashkatov, E. A. Genina, V. I. Kochubey, and V. V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[Crossref] [PubMed]

H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
[Crossref] [PubMed]

2004 (4)

J. C. Finlay and T. H. Foster, “Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation,” Med. Phys. 31(7), 1949–1959 (2004).
[Crossref] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

E. M. Hillman, D. A. Boas, A. M. Dale, and A. K. Dunn, “Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media,” Opt. Lett. 29(14), 1650–1652 (2004).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[Crossref] [PubMed]

2003 (4)

R. Cheung, M. Solonenko, T. M. Busch, F. Del Piero, M. E. Putt, S. M. Hahn, and A. G. Yodh, “Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model,” J. Biomed. Opt. 8(2), 248–252 (2003).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, C. Cheung, D. Furuya, J. H. Greenberg, and A. G. Yodh, “Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest,” Adv. Exp. Med. Biol. 510, 293–297 (2003).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

2002 (4)

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

N. Hirosawa, Y. Sakamoto, H. Katayama, S. Tonooka, and K. Yano, “In vivo investigation of progressive alterations in rat mammary gland tumors by near-infrared spectroscopy,” Anal. Biochem. 305(2), 156–165 (2002).
[Crossref] [PubMed]

M. Solonenko, R. Cheung, T. M. Busch, A. Kachur, G. M. Griffin, T. Vulcan, T. C. Zhu, H. W. Wang, S. M. Hahn, and A. G. Yodh, “In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates,” Phys. Med. Biol. 47(6), 857–873 (2002).
[PubMed]

H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
[Crossref] [PubMed]

2001 (3)

J. C. Finlay, D. L. Conover, E. L. Hull, and T. H. Foster, “Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo,” Photochem. Photobiol. 73(1), 54–63 (2001).
[Crossref] [PubMed]

E. Hull and T. Foster, “Steady-state reflectance spectroscopy in the P3 approximation,” J. Opt. Soc. Am. A 18(3), 584 (2001).
[Crossref]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[Crossref] [PubMed]

2000 (2)

1999 (4)

G. Zonios, L. T. Perelman, V. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, “Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo,” Appl. Opt. 38(31), 6628–6637 (1999).
[Crossref] [PubMed]

R. M. P. Doornbos, R. Lang, M. C. Aalders, F. W. Cross, and H. J. C. M. Sterenborg, “The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy,” Phys. Med. Biol. 44(4), 967–981 (1999).
[Crossref] [PubMed]

S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15(2), R41–R93 (1999).
[Crossref]

E. L. Hull, D. L. Conover, and T. H. Foster, “Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy,” Br. J. Cancer 79(11-12), 1709–1716 (1999).
[Crossref] [PubMed]

1998 (1)

E. L. Hull, M. G. Nichols, and T. H. Foster, “Quantitative broadband near-infrared spectroscopy of tissue-simulating phantoms containing erythrocytes,” Phys. Med. Biol. 43(11), 3381–3404 (1998).
[Crossref] [PubMed]

1997 (3)

R. A. Weersink, J. E. Hayward, K. R. Diamond, and M. S. Patterson, “Accuracy of noninvasive in vivo measurements of photosensitizer uptake based on a diffusion model of reflectance spectroscopy,” Photochem. Photobiol. 66(3), 326–335 (1997).
[Crossref] [PubMed]

M. G. Nichols, E. L. Hull, and T. H. Foster, “Design and testing of a white-light, steady-state diffuse reflectance spectrometer for determination of optical properties of highly scattering systems,” Appl. Opt. 36(1), 93–104 (1997).
[Crossref] [PubMed]

T. K. Bergersen, M. Eriksen, and L. Walløe, “Local constriction of arteriovenous anastomoses in the cooled finger,” Am. J. Physiol. 273(3 Pt 2), R880–R886 (1997).
[PubMed]

1996 (2)

B. M. Kim, S. L. Jacques, S. Rastegar, S. Thomsen, and M. Motamedi, “Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue,” IEEE J. Sel. Top. Quantum Electron. 2(4), 922–933 (1996).
[Crossref]

A. Kienle, L. Lilge, M. S. Patterson, R. Hibst, R. Steiner, and B. C. Wilson, “Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue,” Appl. Opt. 35(13), 2304–2314 (1996).
[Crossref] [PubMed]

1995 (1)

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[Crossref] [PubMed]

1994 (1)

D. M. Mancini, L. Bolinger, H. Li, K. Kendrick, B. Chance, and J. R. Wilson, “Validation of near-infrared spectroscopy in humans,” J. Appl. Physiol. 77(6), 2740–2747 (1994).
[PubMed]

1993 (2)

L. Kou, D. Labrie, and P. Chylek, “Refractive Indices of Water and Ice in the 0.65- to 2.5-µm Spectral Range,” Appl. Opt. 32(19), 3531–3540 (1993).
[Crossref] [PubMed]

K. Wårdell, A. Jakobsson, and G. E. Nilsson, “Laser Doppler perfusion imaging by dynamic light scattering,” IEEE Trans. Biomed. Eng. 40(4), 309–316 (1993).
[Crossref] [PubMed]

1979 (1)

S. Takatani and M. D. Graham, “Theoretical analysis of diffuse reflectance from a two-layer tissue model,” IEEE Trans. Biomed. Eng. 26(12), 656–664 (1979).
[Crossref] [PubMed]

Aalders, M. C.

R. M. P. Doornbos, R. Lang, M. C. Aalders, F. W. Cross, and H. J. C. M. Sterenborg, “The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy,” Phys. Med. Biol. 44(4), 967–981 (1999).
[Crossref] [PubMed]

Akbari, H.

H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
[Crossref] [PubMed]

Alazard, N.

H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
[Crossref] [PubMed]

Alexandrakis, G.

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
[Crossref] [PubMed]

Amelink, A.

R. L. P. van Veen, A. Amelink, M. Menke-Pluymers, C. van der Pol, and H. J. C. M. Sterenborg, “Optical biopsy of breast tissue using differential path-length spectroscopy,” Phys. Med. Biol. 50(11), 2573–2581 (2005).
[Crossref] [PubMed]

Andersson-Engels, S.

Angela Franceschini, M.

E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

Arridge, S. R.

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R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
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C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

Burnett, M. G.

Busch, D. R.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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Busch, T. M.

R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
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T. M. Busch, X. Xing, G. Yu, A. Yodh, E. P. Wileyto, H. W. Wang, T. Durduran, T. C. Zhu, and K. K. Wang, “Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy,” Photochem. Photobiol. Sci. 8, 1683–1693 (2009).

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
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H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
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R. Cheung, M. Solonenko, T. M. Busch, F. Del Piero, M. E. Putt, S. M. Hahn, and A. G. Yodh, “Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model,” J. Biomed. Opt. 8(2), 248–252 (2003).
[Crossref] [PubMed]

M. Solonenko, R. Cheung, T. M. Busch, A. Kachur, G. M. Griffin, T. Vulcan, T. C. Zhu, H. W. Wang, S. M. Hahn, and A. G. Yodh, “In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates,” Phys. Med. Biol. 47(6), 857–873 (2002).
[PubMed]

Butler, J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
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T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
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Campbell, L. E.

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
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Cao, Y.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
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Carp, S. A.

J. Selb, D. A. Boas, S. T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

Cen, H.

Cerussi, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Chan, S. T.

J. Selb, D. A. Boas, S. T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
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Chance, B.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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D. M. Mancini, L. Bolinger, H. Li, K. Kendrick, B. Chance, and J. R. Wilson, “Validation of near-infrared spectroscopy in humans,” J. Appl. Physiol. 77(6), 2740–2747 (1994).
[PubMed]

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H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
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Cheng, R.

Cheung, C.

J. P. Culver, T. Durduran, C. Cheung, D. Furuya, J. H. Greenberg, and A. G. Yodh, “Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest,” Adv. Exp. Med. Biol. 510, 293–297 (2003).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[Crossref] [PubMed]

Cheung, R.

R. Cheung, M. Solonenko, T. M. Busch, F. Del Piero, M. E. Putt, S. M. Hahn, and A. G. Yodh, “Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model,” J. Biomed. Opt. 8(2), 248–252 (2003).
[Crossref] [PubMed]

M. Solonenko, R. Cheung, T. M. Busch, A. Kachur, G. M. Griffin, T. Vulcan, T. C. Zhu, H. W. Wang, S. M. Hahn, and A. G. Yodh, “In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates,” Phys. Med. Biol. 47(6), 857–873 (2002).
[PubMed]

Choe, R.

S. Han, J. Johansson, M. Mireles, A. R. Proctor, M. D. Hoffman, J. B. Vella, D. S. Benoit, T. Durduran, and R. Choe, “Non-contact scanning diffuse correlation tomography system for three-dimensional blood flow imaging in a murine bone graft model,” Biomed. Opt. Express 6(7), 2695–2712 (2015).
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R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
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Chylek, P.

Comelli, D.

P. Taroni, D. Comelli, A. Pifferi, A. Torricelli, and R. Cubeddu, “Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications,” J. Biomed. Opt. 12(1), 014021 (2007).
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Conover, D. L.

J. C. Finlay, D. L. Conover, E. L. Hull, and T. H. Foster, “Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo,” Photochem. Photobiol. 73(1), 54–63 (2001).
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E. L. Hull, D. L. Conover, and T. H. Foster, “Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy,” Br. J. Cancer 79(11-12), 1709–1716 (1999).
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Corlu, A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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R. M. P. Doornbos, R. Lang, M. C. Aalders, F. W. Cross, and H. J. C. M. Sterenborg, “The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy,” Phys. Med. Biol. 44(4), 967–981 (1999).
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Cubeddu, R.

P. Taroni, D. Comelli, A. Pifferi, A. Torricelli, and R. Cubeddu, “Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications,” J. Biomed. Opt. 12(1), 014021 (2007).
[Crossref] [PubMed]

Cuccia, D. J.

Culver, J. P.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

J. P. Culver, T. Durduran, C. Cheung, D. Furuya, J. H. Greenberg, and A. G. Yodh, “Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest,” Adv. Exp. Med. Biol. 510, 293–297 (2003).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[Crossref] [PubMed]

Czerniecki, B. J.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Dale, A. M.

Dam, J. S.

Darzi, A.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: a systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Daugherty, A.

Del Piero, F.

R. Cheung, M. Solonenko, T. M. Busch, F. Del Piero, M. E. Putt, S. M. Hahn, and A. G. Yodh, “Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model,” J. Biomed. Opt. 8(2), 248–252 (2003).
[Crossref] [PubMed]

Demichele, A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Demont, J.

H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
[Crossref] [PubMed]

Detre, J. A.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[Crossref] [PubMed]

Dewhirst, M. W.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

Diamond, K. R.

R. A. Weersink, J. E. Hayward, K. R. Diamond, and M. S. Patterson, “Accuracy of noninvasive in vivo measurements of photosensitizer uptake based on a diffusion model of reflectance spectroscopy,” Photochem. Photobiol. 66(3), 326–335 (1997).
[Crossref] [PubMed]

Dimofte, A.

H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
[Crossref] [PubMed]

Diop, M.

Donovan, O.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
[Crossref] [PubMed]

Doornbos, R. M. P.

R. M. P. Doornbos, R. Lang, M. C. Aalders, F. W. Cross, and H. J. C. M. Sterenborg, “The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy,” Phys. Med. Biol. 44(4), 967–981 (1999).
[Crossref] [PubMed]

Dunn, A. K.

Durduran, T.

S. Han, J. Johansson, M. Mireles, A. R. Proctor, M. D. Hoffman, J. B. Vella, D. S. Benoit, T. Durduran, and R. Choe, “Non-contact scanning diffuse correlation tomography system for three-dimensional blood flow imaging in a murine bone graft model,” Biomed. Opt. Express 6(7), 2695–2712 (2015).
[Crossref] [PubMed]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

T. M. Busch, X. Xing, G. Yu, A. Yodh, E. P. Wileyto, H. W. Wang, T. Durduran, T. C. Zhu, and K. K. Wang, “Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy,” Photochem. Photobiol. Sci. 8, 1683–1693 (2009).

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[Crossref] [PubMed]

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[Crossref] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).

J. P. Culver, T. Durduran, C. Cheung, D. Furuya, J. H. Greenberg, and A. G. Yodh, “Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest,” Adv. Exp. Med. Biol. 510, 293–297 (2003).
[Crossref] [PubMed]

Durkin, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Durkin, A. J.

Durning, S. M.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

Edlow, B. L.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Emanuele, M. J.

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Enfield, L. C.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: a systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Eriksen, M.

T. K. Bergersen, M. Eriksen, and L. Walløe, “Local constriction of arteriovenous anastomoses in the cooled finger,” Am. J. Physiol. 273(3 Pt 2), R880–R886 (1997).
[PubMed]

Ertel, A.

D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
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Esipova, T. V.

R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
[Crossref] [PubMed]

Eucker, S. A.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

Evans, K. C.

J. Selb, D. A. Boas, S. T. Chan, K. C. Evans, E. M. Buckley, and S. A. Carp, “Sensitivity of near-infrared spectroscopy and diffuse correlation spectroscopy to brain hemodynamics: simulations and experimental findings during hypercapnia,” Neurophotonics 1(1), 015005 (2014).
[Crossref] [PubMed]

Faller, D. V.

S. V. Panasyuk, S. Yang, D. V. Faller, D. Ngo, R. A. Lew, J. E. Freeman, and A. E. Rogers, “Medical hyperspectral imaging to facilitate residual tumor identification during surgery,” Cancer Biol. Ther. 6(3), 439–446 (2007).
[Crossref] [PubMed]

Fantini, S.

Fei, B.

H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
[Crossref] [PubMed]

Feld, M. S.

Finlay, J. C.

J. C. Finlay and T. H. Foster, “Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation,” Med. Phys. 31(7), 1949–1959 (2004).
[Crossref] [PubMed]

J. C. Finlay, D. L. Conover, E. L. Hull, and T. H. Foster, “Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo,” Photochem. Photobiol. 73(1), 54–63 (2001).
[Crossref] [PubMed]

Fitzmaurice, M.

Flomenberg, N.

D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
[Crossref] [PubMed]

Floyd, T. F.

Foschum, F.

F. Foschum, M. Jäger, and A. Kienle, “Fully automated spatially resolved reflectance spectrometer for the determination of the absorption and scattering in turbid media,” Rev. Sci. Instrum. 82(10), 103104 (2011).
[Crossref] [PubMed]

Foster, T.

Foster, T. H.

T. M. Baran, J. D. Wilson, S. Mitra, J. L. Yao, E. M. Messing, D. L. Waldman, and T. H. Foster, “Optical property measurements establish the feasibility of photodynamic therapy as a minimally invasive intervention for tumors of the kidney,” J. Biomed. Opt. 17(9), 098002 (2012).
[Crossref] [PubMed]

J. C. Finlay and T. H. Foster, “Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation,” Med. Phys. 31(7), 1949–1959 (2004).
[Crossref] [PubMed]

J. C. Finlay, D. L. Conover, E. L. Hull, and T. H. Foster, “Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo,” Photochem. Photobiol. 73(1), 54–63 (2001).
[Crossref] [PubMed]

E. L. Hull, D. L. Conover, and T. H. Foster, “Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy,” Br. J. Cancer 79(11-12), 1709–1716 (1999).
[Crossref] [PubMed]

E. L. Hull, M. G. Nichols, and T. H. Foster, “Quantitative broadband near-infrared spectroscopy of tissue-simulating phantoms containing erythrocytes,” Phys. Med. Biol. 43(11), 3381–3404 (1998).
[Crossref] [PubMed]

M. G. Nichols, E. L. Hull, and T. H. Foster, “Design and testing of a white-light, steady-state diffuse reflectance spectrometer for determination of optical properties of highly scattering systems,” Appl. Opt. 36(1), 93–104 (1997).
[Crossref] [PubMed]

Fraker, D. L.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
[Crossref] [PubMed]

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

Franceschini, M. A.

E. M. Buckley, S. D. Patel, B. F. Miller, M. A. Franceschini, and S. J. Vannucci, “In vivo Monitoring of Cerebral Hemodynamics in the Immature Rat: Effects of Hypoxia-Ischemia and Hypothermia,” Dev. Neurosci. 37(4-5), 407–416 (2015).
[Crossref] [PubMed]

Frangos, S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Freeman, J. E.

S. V. Panasyuk, S. Yang, D. V. Faller, D. Ngo, R. A. Lew, J. E. Freeman, and A. E. Rogers, “Medical hyperspectral imaging to facilitate residual tumor identification during surgery,” Cancer Biol. Ther. 6(3), 439–446 (2007).
[Crossref] [PubMed]

Friess, S. H.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

Furuya, D.

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).

J. P. Culver, T. Durduran, C. Cheung, D. Furuya, J. H. Greenberg, and A. G. Yodh, “Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest,” Adv. Exp. Med. Biol. 510, 293–297 (2003).
[Crossref] [PubMed]

Gallou, C.

H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
[Crossref] [PubMed]

Gao, L.

R. T. Kester, N. Bedard, L. Gao, and T. S. Tkaczyk, “Real-time snapshot hyperspectral imaging endoscope,” J. Biomed. Opt. 16(5), 056005 (2011).
[Crossref] [PubMed]

Gaynor, J. W.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

Genina, E. A.

A. N. Bashkatov, E. A. Genina, V. I. Kochubey, and V. V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

Gibson, A.

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: a systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
[Crossref] [PubMed]

Glatstein, E.

H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
[Crossref] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[Crossref] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Godinot, C.

H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
[Crossref] [PubMed]

Golinski, J. M.

E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

Grady, M. S.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

Graham, M. D.

S. Takatani and M. D. Graham, “Theoretical analysis of diffuse reflectance from a two-layer tissue model,” IEEE Trans. Biomed. Eng. 26(12), 656–664 (1979).
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Greenberg, J.

Greenberg, J. H.

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Martinez-Outschoorn, U. E.

D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
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Mason, S. E.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
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Master, V.

H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
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E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

Meehan Iii, W. P.

E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

Mehta, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
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C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
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R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
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R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
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R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
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T. M. Baran, J. D. Wilson, S. Mitra, J. L. Yao, E. M. Messing, D. L. Waldman, and T. H. Foster, “Optical property measurements establish the feasibility of photodynamic therapy as a minimally invasive intervention for tumors of the kidney,” J. Biomed. Opt. 17(9), 098002 (2012).
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H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
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H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
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E. M. Buckley, S. D. Patel, B. F. Miller, M. A. Franceschini, and S. J. Vannucci, “In vivo Monitoring of Cerebral Hemodynamics in the Immature Rat: Effects of Hypoxia-Ischemia and Hypothermia,” Dev. Neurosci. 37(4-5), 407–416 (2015).
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E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

Miller, E. L.

Miller, J.

R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
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D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
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Mireles, M.

Mitra, S.

T. M. Baran, J. D. Wilson, S. Mitra, J. L. Yao, E. M. Messing, D. L. Waldman, and T. H. Foster, “Optical property measurements establish the feasibility of photodynamic therapy as a minimally invasive intervention for tumors of the kidney,” J. Biomed. Opt. 17(9), 098002 (2012).
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Moeller, B. J.

B. S. Sorg, B. J. Moeller, O. Donovan, Y. Cao, and M. W. Dewhirst, “Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development,” J. Biomed. Opt. 10(4), 044004 (2005).
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T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
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Moss, H. E.

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
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B. M. Kim, S. L. Jacques, S. Rastegar, S. Thomsen, and M. Motamedi, “Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue,” IEEE J. Sel. Top. Quantum Electron. 2(4), 922–933 (1996).
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Nachabé, R.

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
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K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
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E. L. Hull, M. G. Nichols, and T. H. Foster, “Quantitative broadband near-infrared spectroscopy of tissue-simulating phantoms containing erythrocytes,” Phys. Med. Biol. 43(11), 3381–3404 (1998).
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H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
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Osunkoya, A.

H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
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C. Zhu, G. M. Palmer, T. M. Breslin, J. Harter, and N. Ramanujam, “Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique,” Lasers Surg. Med. 38(7), 714–724 (2006).
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S. V. Panasyuk, S. Yang, D. V. Faller, D. Ngo, R. A. Lew, J. E. Freeman, and A. E. Rogers, “Medical hyperspectral imaging to facilitate residual tumor identification during surgery,” Cancer Biol. Ther. 6(3), 439–446 (2007).
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Paquette, A. D.

Patel, S. D.

E. M. Buckley, S. D. Patel, B. F. Miller, M. A. Franceschini, and S. J. Vannucci, “In vivo Monitoring of Cerebral Hemodynamics in the Immature Rat: Effects of Hypoxia-Ischemia and Hypothermia,” Dev. Neurosci. 37(4-5), 407–416 (2015).
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D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
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Pestell, R. G.

D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
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H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
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Pham, T. H.

Pifferi, A.

P. Taroni, D. Comelli, A. Pifferi, A. Torricelli, and R. Cubeddu, “Absorption of collagen: effects on the estimate of breast composition and related diagnostic implications,” J. Biomed. Opt. 12(1), 014021 (2007).
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Pingpank, J. F.

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

Pole, A.

R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
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Polin, G. M.

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

Prabakaran, I.

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

Proctor, A. R.

Putt, M. E.

R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
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T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
[Crossref] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
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H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
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R. Cheung, M. Solonenko, T. M. Busch, F. Del Piero, M. E. Putt, S. M. Hahn, and A. G. Yodh, “Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model,” J. Biomed. Opt. 8(2), 248–252 (2003).
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Ralston, J.

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

Ramanujam, N.

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
[Crossref] [PubMed]

C. Zhu, G. M. Palmer, T. M. Breslin, J. Harter, and N. Ramanujam, “Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique,” Lasers Surg. Med. 38(7), 714–724 (2006).
[Crossref] [PubMed]

Rastegar, S.

B. M. Kim, S. L. Jacques, S. Rastegar, S. Thomsen, and M. Motamedi, “Nonlinear finite-element analysis of the role of dynamic changes in blood perfusion and optical properties in laser coagulation of tissue,” IEEE J. Sel. Top. Quantum Electron. 2(4), 922–933 (1996).
[Crossref]

Rogers, A. E.

S. V. Panasyuk, S. Yang, D. V. Faller, D. Ngo, R. A. Lew, J. E. Freeman, and A. E. Rogers, “Medical hyperspectral imaging to facilitate residual tumor identification during surgery,” Cancer Biol. Ther. 6(3), 439–446 (2007).
[Crossref] [PubMed]

Rosen, M. A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Sadeghian, H.

E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

Sakamoto, Y.

N. Hirosawa, Y. Sakamoto, H. Katayama, S. Tonooka, and K. Yano, “In vivo investigation of progressive alterations in rat mammary gland tumors by near-infrared spectroscopy,” Anal. Biochem. 305(2), 156–165 (2002).
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Saunders, H. M.

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
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K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
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Schägger, H.

H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
[Crossref] [PubMed]

Schenkel, S.

Schenkel, S. S.

R. C. Mesquita, S. W. Han, J. Miller, S. S. Schenkel, A. Pole, T. V. Esipova, S. A. Vinogradov, M. E. Putt, A. G. Yodh, and T. M. Busch, “Tumor Blood Flow Differs between Mouse Strains: Consequences for Vasoresponse to Photodynamic Therapy,” PLoS One 7(5), e37322 (2012).
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T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

R. C. Mesquita, N. Skuli, M. N. Kim, J. Liang, S. Schenkel, A. J. Majmundar, M. C. Simon, and A. G. Yodh, “Hemodynamic and metabolic diffuse optical monitoring in a mouse model of hindlimb ischemia,” Biomed. Opt. Express 1(4), 1173–1187 (2010).
[Crossref] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[Crossref] [PubMed]

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
[Crossref] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[Crossref] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).

J. P. Culver, T. Durduran, C. Cheung, D. Furuya, J. H. Greenberg, and A. G. Yodh, “Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest,” Adv. Exp. Med. Biol. 510, 293–297 (2003).
[Crossref] [PubMed]

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
[PubMed]

R. Cheung, M. Solonenko, T. M. Busch, F. Del Piero, M. E. Putt, S. M. Hahn, and A. G. Yodh, “Correlation of in vivo photosensitizer fluorescence and photodynamic-therapy-induced depth of necrosis in a murine tumor model,” J. Biomed. Opt. 8(2), 248–252 (2003).
[Crossref] [PubMed]

M. Solonenko, R. Cheung, T. M. Busch, A. Kachur, G. M. Griffin, T. Vulcan, T. C. Zhu, H. W. Wang, S. M. Hahn, and A. G. Yodh, “In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates,” Phys. Med. Biol. 47(6), 857–873 (2002).
[PubMed]

C. Cheung, J. P. Culver, K. Takahashi, J. H. Greenberg, and A. G. Yodh, “In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies,” Phys. Med. Biol. 46(8), 2053–2065 (2001).
[Crossref] [PubMed]

D. A. Boas, L. E. Campbell, and A. G. Yodh, “Scattering and Imaging with Diffusing Temporal Field Correlations,” Phys. Rev. Lett. 75(9), 1855–1858 (1995).
[Crossref] [PubMed]

Yu, G.

L. He, Y. Lin, C. Huang, D. Irwin, M. M. Szabunio, and G. Yu, “Noncontact diffuse correlation tomography of human breast tumor,” J. Biomed. Opt. 20(8), 086003 (2015).
[Crossref] [PubMed]

C. Huang, Y. Lin, L. He, D. Irwin, M. M. Szabunio, and G. Yu, “Alignment of sources and detectors on breast surface for noncontact diffuse correlation tomography of breast tumors,” Appl. Opt. 54(29), 8808–8816 (2015).
[Crossref] [PubMed]

Y. Lin, C. Huang, D. Irwin, L. He, Y. Shang, and G. Yu, “Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography,” Appl. Phys. Lett. 104(12), 121103 (2014).
[Crossref] [PubMed]

R. Cheng, X. Zhang, A. Daugherty, H. Shin, and G. Yu, “Noninvasive quantification of postocclusive reactive hyperemia in mouse thigh muscle by near-infrared diffuse correlation spectroscopy,” Appl. Opt. 52(30), 7324–7330 (2013).
[Crossref] [PubMed]

T. Li, Y. Lin, Y. Shang, L. He, C. Huang, M. Szabunio, and G. Yu, “Simultaneous measurement of deep tissue blood flow and oxygenation using noncontact diffuse correlation spectroscopy flow-oximeter,” Sci. Rep. 3, 1358 (2013).
[Crossref] [PubMed]

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

T. M. Busch, X. Xing, G. Yu, A. Yodh, E. P. Wileyto, H. W. Wang, T. Durduran, T. C. Zhu, and K. K. Wang, “Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy,” Photochem. Photobiol. Sci. 8, 1683–1693 (2009).

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[Crossref] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[Crossref] [PubMed]

Yu, J. S.

Zhang, X.

Zhou, C.

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
[Crossref] [PubMed]

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
[Crossref] [PubMed]

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
[Crossref] [PubMed]

G. Yu, T. F. Floyd, T. Durduran, C. Zhou, J. Wang, J. A. Detre, and A. G. Yodh, “Validation of diffuse correlation spectroscopy for muscle blood flow with concurrent arterial spin labeled perfusion MRI,” Opt. Express 15(3), 1064–1075 (2007).
[Crossref] [PubMed]

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

C. Zhou, G. Yu, D. Furuya, J. Greenberg, A. Yodh, and T. Durduran, “Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain,” Opt. Express 14(3), 1125–1144 (2006).
[Crossref] [PubMed]

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
[Crossref] [PubMed]

T. Durduran, G. Yu, M. G. Burnett, J. A. Detre, J. H. Greenberg, J. Wang, C. Zhou, and A. G. Yodh, “Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation,” Opt. Lett. 29(15), 1766–1768 (2004).
[Crossref] [PubMed]

Zhu, C.

C. Zhu, G. M. Palmer, T. M. Breslin, J. Harter, and N. Ramanujam, “Diagnosis of breast cancer using diffuse reflectance spectroscopy: Comparison of a Monte Carlo versus partial least squares analysis based feature extraction technique,” Lasers Surg. Med. 38(7), 714–724 (2006).
[Crossref] [PubMed]

Zhu, T. C.

T. M. Busch, X. Xing, G. Yu, A. Yodh, E. P. Wileyto, H. W. Wang, T. Durduran, T. C. Zhu, and K. K. Wang, “Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy,” Photochem. Photobiol. Sci. 8, 1683–1693 (2009).

H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
[Crossref] [PubMed]

M. Solonenko, R. Cheung, T. M. Busch, A. Kachur, G. M. Griffin, T. Vulcan, T. C. Zhu, H. W. Wang, S. M. Hahn, and A. G. Yodh, “In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates,” Phys. Med. Biol. 47(6), 857–873 (2002).
[PubMed]

Zimmerman, R. A.

T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
[Crossref] [PubMed]

Zong, Y.

Zonios, G.

Zuzak, K. J.

K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
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K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

Adv. Exp. Med. Biol. (1)

J. P. Culver, T. Durduran, C. Cheung, D. Furuya, J. H. Greenberg, and A. G. Yodh, “Diffuse optical measurement of hemoglobin and cerebral blood flow in rat brain during hypercapnia, hypoxia and cardiac arrest,” Adv. Exp. Med. Biol. 510, 293–297 (2003).
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Am. J. Physiol. (1)

T. K. Bergersen, M. Eriksen, and L. Walløe, “Local constriction of arteriovenous anastomoses in the cooled finger,” Am. J. Physiol. 273(3 Pt 2), R880–R886 (1997).
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Anal. Biochem. (1)

N. Hirosawa, Y. Sakamoto, H. Katayama, S. Tonooka, and K. Yano, “In vivo investigation of progressive alterations in rat mammary gland tumors by near-infrared spectroscopy,” Anal. Biochem. 305(2), 156–165 (2002).
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Anal. Chem. (2)

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
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K. J. Zuzak, S. C. Naik, G. Alexandrakis, D. Hawkins, K. Behbehani, and E. H. Livingston, “Characterization of a near-infrared laparoscopic hyperspectral imaging system for minimally invasive surgery,” Anal. Chem. 79(12), 4709–4715 (2007).
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Appl. Opt. (8)

R. Cheng, X. Zhang, A. Daugherty, H. Shin, and G. Yu, “Noninvasive quantification of postocclusive reactive hyperemia in mouse thigh muscle by near-infrared diffuse correlation spectroscopy,” Appl. Opt. 52(30), 7324–7330 (2013).
[Crossref] [PubMed]

M. G. Nichols, E. L. Hull, and T. H. Foster, “Design and testing of a white-light, steady-state diffuse reflectance spectrometer for determination of optical properties of highly scattering systems,” Appl. Opt. 36(1), 93–104 (1997).
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G. Zonios, L. T. Perelman, V. Backman, R. Manoharan, M. Fitzmaurice, J. Van Dam, and M. S. Feld, “Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo,” Appl. Opt. 38(31), 6628–6637 (1999).
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C. Huang, Y. Lin, L. He, D. Irwin, M. M. Szabunio, and G. Yu, “Alignment of sources and detectors on breast surface for noncontact diffuse correlation tomography of breast tumors,” Appl. Opt. 54(29), 8808–8816 (2015).
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T. H. Pham, F. Bevilacqua, T. Spott, J. S. Dam, B. J. Tromberg, and S. Andersson-Engels, “Quantifying the absorption and reduced scattering coefficients of tissuelike turbid media over a broad spectral range with noncontact Fourier-transform hyperspectral imaging,” Appl. Opt. 39(34), 6487–6497 (2000).
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L. Kou, D. Labrie, and P. Chylek, “Refractive Indices of Water and Ice in the 0.65- to 2.5-µm Spectral Range,” Appl. Opt. 32(19), 3531–3540 (1993).
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Y. Zong, S. W. Brown, B. C. Johnson, K. R. Lykke, and Y. Ohno, “Simple spectral stray light correction method for array spectroradiometers,” Appl. Opt. 45(6), 1111–1119 (2006).
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A. Kienle, L. Lilge, M. S. Patterson, R. Hibst, R. Steiner, and B. C. Wilson, “Spatially resolved absolute diffuse reflectance measurements for noninvasive determination of the optical scattering and absorption coefficients of biological tissue,” Appl. Opt. 35(13), 2304–2314 (1996).
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Appl. Phys. Lett. (1)

Y. Lin, C. Huang, D. Irwin, L. He, Y. Shang, and G. Yu, “Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography,” Appl. Phys. Lett. 104(12), 121103 (2014).
[Crossref] [PubMed]

Biomed. Opt. Express (5)

Biosystems Eng. (1)

R. F. Lu and Y. K. Peng, “Hyperspectral scattering for assessing peach fruit firmness,” Biosystems Eng. 93(2), 161–171 (2006).
[Crossref]

Br. J. Cancer (1)

E. L. Hull, D. L. Conover, and T. H. Foster, “Carbogen-induced changes in rat mammary tumour oxygenation reported by near infrared spectroscopy,” Br. J. Cancer 79(11-12), 1709–1716 (1999).
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Breast Cancer Res. Treat. (1)

D. R. Leff, O. J. Warren, L. C. Enfield, A. Gibson, T. Athanasiou, D. K. Patten, J. Hebden, G. Z. Yang, and A. Darzi, “Diffuse optical imaging of the healthy and diseased breast: a systematic review,” Breast Cancer Res. Treat. 108(1), 9–22 (2008).
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Cancer Biol. Ther. (1)

S. V. Panasyuk, S. Yang, D. V. Faller, D. Ngo, R. A. Lew, J. E. Freeman, and A. E. Rogers, “Medical hyperspectral imaging to facilitate residual tumor identification during surgery,” Cancer Biol. Ther. 6(3), 439–446 (2007).
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Cancer Res. (2)

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

C. Menon, G. M. Polin, I. Prabakaran, A. Hsi, C. Cheung, J. P. Culver, J. F. Pingpank, C. S. Sehgal, A. G. Yodh, D. G. Buerk, and D. L. Fraker, “An integrated approach to measuring tumor oxygen status using human melanoma xenografts as a model,” Cancer Res. 63(21), 7232–7240 (2003).
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Carcinogenesis (1)

H. Simonnet, N. Alazard, K. Pfeiffer, C. Gallou, C. Béroud, J. Demont, R. Bouvier, H. Schägger, and C. Godinot, “Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma,” Carcinogenesis 23(5), 759–768 (2002).
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Cell Cycle (1)

D. Whitaker-Menezes, U. E. Martinez-Outschoorn, N. Flomenberg, R. C. Birbe, A. K. Witkiewicz, A. Howell, S. Pavlides, A. Tsirigos, A. Ertel, R. G. Pestell, P. Broda, C. Minetti, M. P. Lisanti, and F. Sotgia, “Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue,” Cell Cycle 10(23), 4047–4064 (2011).
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Clin. Cancer Res. (1)

G. Yu, T. Durduran, C. Zhou, H. W. Wang, M. E. Putt, H. M. Saunders, C. M. Sehgal, E. Glatstein, A. G. Yodh, and T. M. Busch, “Noninvasive monitoring of murine tumor blood flow during and after photodynamic therapy provides early assessment of therapeutic efficacy,” Clin. Cancer Res. 11(9), 3543–3552 (2005).
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Dev. Neurosci. (1)

E. M. Buckley, S. D. Patel, B. F. Miller, M. A. Franceschini, and S. J. Vannucci, “In vivo Monitoring of Cerebral Hemodynamics in the Immature Rat: Effects of Hypoxia-Ischemia and Hypothermia,” Dev. Neurosci. 37(4-5), 407–416 (2015).
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C. Zhou, S. A. Eucker, T. Durduran, G. Yu, J. Ralston, S. H. Friess, R. N. Ichord, S. S. Margulies, and A. G. Yodh, “Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury,” J. Biomed. Opt. 14(3), 034015 (2009).
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T. Durduran, C. Zhou, E. M. Buckley, M. N. Kim, G. Yu, R. Choe, J. W. Gaynor, T. L. Spray, S. M. Durning, S. E. Mason, L. M. Montenegro, S. C. Nicolson, R. A. Zimmerman, M. E. Putt, J. Wang, J. H. Greenberg, J. A. Detre, A. G. Yodh, and D. J. Licht, “Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects,” J. Biomed. Opt. 15(3), 037004 (2010).
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H. W. Wang, T. C. Zhu, M. E. Putt, M. Solonenko, J. Metz, A. Dimofte, J. Miles, D. L. Fraker, E. Glatstein, S. M. Hahn, and A. G. Yodh, “Broadband reflectance measurements of light penetration, blood oxygenation, hemoglobin concentration, and drug concentration in human intraperitoneal tissues before and after photodynamic therapy,” J. Biomed. Opt. 10(1), 014004 (2005).
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H. Akbari, L. V. Halig, D. M. Schuster, A. Osunkoya, V. Master, P. T. Nieh, G. Z. Chen, and B. Fei, “Hyperspectral imaging and quantitative analysis for prostate cancer detection,” J. Biomed. Opt. 17(7), 076005 (2012).
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L. He, Y. Lin, C. Huang, D. Irwin, M. M. Szabunio, and G. Yu, “Noncontact diffuse correlation tomography of human breast tumor,” J. Biomed. Opt. 20(8), 086003 (2015).
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C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
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R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
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J. Biophotonics (1)

T. M. Bydlon, R. Nachabé, N. Ramanujam, H. J. Sterenborg, and B. H. Hendriks, “Chromophore based analyses of steady-state diffuse reflectance spectroscopy: current status and perspectives for clinical adoption,” J. Biophotonics 8(1-2), 9–24 (2015).
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J. Cereb. Blood Flow Metab. (2)

J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, “Diffuse optical tomography of cerebral blood flow, oxygenation, and metabolism in rat during focal ischemia,” J. Cereb. Blood Flow Metab. 23, 911–924 (2003).

E. M. Buckley, B. F. Miller, J. M. Golinski, H. Sadeghian, L. M. McAllister, M. Vangel, C. Ayata, W. P. Meehan Iii, M. Angela Franceschini, and M. J. Whalen, “Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice,” J. Cereb. Blood Flow Metab. 35, 1995–2000 (2015).

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J. J. Xia, E. P. Berg, J. W. Lee, and G. Yao, “Characterizing beef muscles with optical scattering and absorption coefficients in VIS-NIR region,” Meat Sci. 75(1), 78–83 (2007).
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Med. Phys. (1)

J. C. Finlay and T. H. Foster, “Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation,” Med. Phys. 31(7), 1949–1959 (2004).
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Neurocrit. Care (1)

M. N. Kim, T. Durduran, S. Frangos, B. L. Edlow, E. M. Buckley, H. E. Moss, C. Zhou, G. Yu, R. Choe, E. Maloney-Wilensky, R. L. Wolf, M. S. Grady, J. H. Greenberg, J. M. Levine, A. G. Yodh, J. A. Detre, and W. A. Kofke, “Noninvasive Measurement of Cerebral Blood Flow and Blood Oxygenation Using Near-Infrared and Diffuse Correlation Spectroscopies in Critically Brain-Injured Adults,” Neurocrit. Care 12(2), 173–180 (2010).
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Opt. Express (5)

Opt. Lett. (3)

Philos Trans A Math Phys Eng Sci (1)

R. C. Mesquita, T. Durduran, G. Yu, E. M. Buckley, M. N. Kim, C. Zhou, R. Choe, U. Sunar, and A. G. Yodh, “Direct measurement of tissue blood flow and metabolism with diffuse optics,” Philos Trans A Math Phys Eng Sci 369(1955), 4390–4406 (2011).
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T. M. Busch, X. Xing, G. Yu, A. Yodh, E. P. Wileyto, H. W. Wang, T. Durduran, T. C. Zhu, and K. K. Wang, “Fluence rate-dependent intratumor heterogeneity in physiologic and cytotoxic responses to Photofrin photodynamic therapy,” Photochem. Photobiol. Sci. 8, 1683–1693 (2009).

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Phys. Rev. Lett. (1)

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PLoS One (1)

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Rep. Prog. Phys. (1)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
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Figures (8)

Fig. 1
Fig. 1 System overview. Laser and broadband light are alternatingly sent and focussed through a set of achromatic lenses on a spot on the target. The diffusely reflected light is captured along a line from the source spot, split by a beamsplitter and focussed by another achromatic lens to the slit of a spectrometer and an array of DCS detector fibres. Scanning is done by translational movement of the target.
Fig. 2
Fig. 2 Typical hyperspectral data acquired with our systems. Complete usage of the CCD with the non-contact system (b) provides many source-detector separations compared to the contact system (a) with discrete number of detectors placed at a certain source-detector separation.
Fig. 3
Fig. 3 The height change of the object relative to a reference position is a function of the light peak displacement on the CCD and the incoming angle of light.
Fig. 4
Fig. 4 (a) Signal-to-noise ratio as mean divided by standard deviation over time (2 min) for the longest and shortest source-detector separations used. (b) Spectral fits for two different source-detector combinations. (c) Residuals for the fits. A small peak around 635 nm can be seen, possibly corresponding to methaemoglobin [58].
Fig. 5
Fig. 5 Results from the five liquid phantoms with varying concentrations of diluted blue ink and Lipofundin (LF). (a) Estimated values of ink concentration and µs' at 785 nm. Dashed lines mark expected ink and reduced scattering coefficient values. (b) Estimated Db values. Error bars are standard-deviation over the scanning positions.
Fig. 6
Fig. 6 Results from occlusion test in fingertip. Stasis was induced after 2 minute of baseline measurement and maintained for 3 minutes. (a) BFI drops to almost 0 during the occlusion while (b) THC stays relatively unchanged and (c) StO2 gradually decays over time as expected. (Error bars are s.d. over source-detector separations, displayed for every fifth time point.)
Fig. 7
Fig. 7 Scanning of renal cell carcinoma tumour. Regions of interest for comparison with probe measurements are marked with white outlines. Each pixel corresponds to the approximate middle of the line between the light source and the detector points for each measurement.
Fig. 8
Fig. 8 Comparison of median values for (a) blood flow index (BFI), (b) total haemoglobin concentration (THC), (c) tissue oxygen saturation (StO2) and (d) the reduced scattering coefficient at 785 nm obtained from the scanning system (S) and a self-calibrating optical probe (P) in seven mice. The boxplots represent the variability over the mice, visualized by median (central line), quartiles, i.e. the 25 and 75-percentiles (box edges), data range within one time of the interquartile range from the quartiles (whiskers) and all data points (crosses and stars).

Tables (2)

Tables Icon

Table 1 Summary of the system parameters for DOS-DCS measurements.

Tables Icon

Table 2 Tabulation of results from non-contact and contact measurements are shown for the seven mice. BFI, THC, StO2 and µs' are reported for the tumour, hind leg and foreleg areas. Differences (Diff: probe – scanner results) are reported together with corresponding statistics for paired t-tests. s.d. denotes standard deviation over the named quantity.

Equations (7)

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Δh= Δx× S r tan( θ )
ρ i = i× F d 0.5 ( Δx× S r ).
G= 3 μ s 4π ( exp( ν r 1 ) r 1 exp( ν r 2 ) r 2 + exp( ν r 3 ) r 3 exp( ν r 4 ) r 4 )
μ s = A 1 ( λ/ λ 0 ) b + A 2 ( λ/ λ 0 ) 4
g 1 =( exp( K(τ) r 1 ) r 1 exp( K(τ) r 2 ) r 2 )/( exp( K(0) r 1 ) r 1 exp( K(0) r 2 ) r 2 )
Where K(τ)= [ 3 μ a μ s +6α D b τ μ s 2 ( 2πn/λ ) 2 ] 1/2
g 2 =1+β | g 1 | 2

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