Abstract

Photoacoustic tomography, a hybrid imaging modality combining optical and ultrasound imaging, is gaining attention in the field of medical imaging. Typically, a Q-switched Nd:YAG laser is used to excite the tissue and generate photoacoustic signals. But, such photoacoustic imaging systems are difficult to translate into clinical applications owing to their high cost, bulky size often requiring an optical table to house such lasers. Moreover, the low pulse repetition rate of few tens of hertz prevents them from being used in high frame rate photoacoustic imaging. In this work, we have demonstrated up to 7000 Hz photoacoustic imaging (B-mode) and measured the flow rate of a fast moving object. We used a ~140 nanosecond pulsed laser diode as an excitation source and a clinical ultrasound imaging system to capture and display the photoacoustic images. The excitation laser is ~803 nm in wavelength with ~1.4 mJ energy per pulse. So far, the reported 2-dimensional photoacoustic B-scan imaging is only a few tens of frames per second using a clinical ultrasound system. Therefore, this is the first report on 2-dimensional photoacoustic B-scan imaging with 7000 frames per second. We have demonstrated phantom imaging to view and measure the flow rate of ink solution inside a tube. This fast photoacoustic imaging can be useful for various clinical applications including cardiac related problems, where the blood flow rate is quite high, or other dynamic studies.

© 2016 Optical Society of America

Full Article  |  PDF Article
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References

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2015 (11)

A. Taruttis and V. Ntziachristos, “Advances in real-time multispectral optoacoustic imaging and its applications,” Nat. Photonics 9(4), 219–227 (2015).
[Crossref]

X. Li, C. D. Heldermon, L. Yao, L. Xi, and H. Jiang, “High resolution functional photoacoustic tomography of breast cancer,” Med. Phys. 42(9), 5321–5328 (2015).
[Crossref] [PubMed]

W. Li and X. Chen, “Gold nanoparticles for photoacoustic imaging,” Nanomedicine (Lond.) 10(2), 299–320 (2015).
[Crossref] [PubMed]

H. Huang, G. Bustamante, R. Peterson, and J. Y. Ye, “An adaptive filtered back-projection for photoacoustic image reconstruction,” Med. Phys. 42(5), 2169–2178 (2015).
[Crossref] [PubMed]

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

X. L. Deán-Ben, S. J. Ford, and D. Razansky, “High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion,” Sci. Rep. 5, 10133 (2015).
[Crossref] [PubMed]

P. K. Upputuri and M. Pramanik, “Pulsed laser diode based optoacoustic imaging of biological tissues,” Biomed. Phys. Eng. Express 1(4), 045010 (2015).
[Crossref]

R. Li, P. Wang, L. Lan, F. P. Lloyd, C. J. Goergen, S. Chen, and J.-X. Cheng, “Assessing breast tumor margin by multispectral photoacoustic tomography,” Biomed. Opt. Express 6(4), 1273–1281 (2015).
[Crossref] [PubMed]

G. Diot, A. Dima, and V. Ntziachristos, “Multispectral opto-acoustic tomography of exercised muscle oxygenation,” Opt. Lett. 40(7), 1496–1499 (2015).
[Crossref] [PubMed]

B. Z. Chen, J. G. Yang, D. Wu, D. W. Zeng, Y. Yi, N. Yang, and H. B. Jiang, “Photoacoustic imaging of cerebral hypoperfusion during acupuncture,” Biomed. Opt. Express 6(9), 3225–3234 (2015).
[Crossref] [PubMed]

P. K. Upputuri and M. Pramanik, “Performance characterization of low-cost, high-speed, portable pulsed laser diode photoacoustic tomography (PLD-PAT) system,” Biomed. Opt. Express 6(10), 4118–4129 (2015).
[Crossref] [PubMed]

2014 (7)

C. Lutzweiler, X. L. Deán-Ben, and D. Razansky, “Expediting model-based optoacoustic reconstructions with tomographic symmetries,” Med. Phys. 41(1), 013302 (2014).
[Crossref] [PubMed]

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

M. Pramanik, “Improving tangential resolution with a modified delay-and-sum reconstruction algorithm in photoacoustic and thermoacoustic tomography,” J. Opt. Soc. Am. A 31(3), 621–627 (2014).
[Crossref] [PubMed]

J. Prakash, A. S. Raju, C. B. Shaw, M. Pramanik, and P. K. Yalavarthy, “Basis pursuit deconvolution for improving model-based reconstructed images in photoacoustic tomography,” Biomed. Opt. Express 5(5), 1363–1377 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

2013 (6)

W. Xia, D. Piras, M. K. A. Singh, J. C. G. van Hespen, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Design and evaluation of a laboratory prototype system for 3D photoacoustic full breast tomography,” Biomed. Opt. Express 4(11), 2555–2569 (2013).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

E. I. Galanzha and V. P. Zharov, “Circulating tumor cell detection and capture by photoacoustic flow cytometry in vivo and ex vivo,” Cancers (Basel) 5(4), 1691–1738 (2013).
[Crossref] [PubMed]

L. Xiang, B. Wang, L. Ji, and H. Jiang, “4-D photoacoustic tomography,” Sci. Rep. 3, 1113 (2013).
[Crossref] [PubMed]

C. Huang, K. Wang, L. Nie, L. V. Wang, and M. A. Anastasio, “Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media,” IEEE Trans. Med. Imaging 32(6), 1097–1110 (2013).
[Crossref] [PubMed]

L. G. Montilla, R. Olafsson, D. R. Bauer, and R. S. Witte, “Real-time photoacoustic and ultrasound imaging: a simple solution for clinical ultrasound systems with linear arrays,” Phys. Med. Biol. 58(1), N1–N12 (2013).
[Crossref] [PubMed]

2012 (2)

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

2011 (2)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

T. Azar, J. Sharp, and D. Lawson, “Heart Rates of Male and Female Sprague-Dawley and Spontaneously Hypertensive Rats Housed Singly or in Groups,” J. Am. Assoc. Lab. Anim. Sci. 50(2), 175–184 (2011).
[PubMed]

2010 (4)

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

2009 (3)

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt. 14(5), 054024 (2009).
[Crossref] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, “Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent,” J. Biomed. Opt. 14(3), 034018 (2009).
[Crossref] [PubMed]

2008 (5)

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys. 35(12), 5758–5767 (2008).
[Crossref] [PubMed]

M. Pramanik, G. Ku, C. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[Crossref] [PubMed]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer,” Opt. Express 16(11), 7915–7928 (2008).
[Crossref] [PubMed]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express 16(22), 18551–18556 (2008).
[Crossref] [PubMed]

2007 (1)

X. Yang, S. E. Skrabalak, Z.-Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent,” Nano Lett. 7(12), 3798–3802 (2007).
[Crossref] [PubMed]

Achilefu, S.

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

Aguirre, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

Akers, W. J.

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

Anastasio, M. A.

C. Huang, K. Wang, L. Nie, L. V. Wang, and M. A. Anastasio, “Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media,” IEEE Trans. Med. Imaging 32(6), 1097–1110 (2013).
[Crossref] [PubMed]

Azar, T.

T. Azar, J. Sharp, and D. Lawson, “Heart Rates of Male and Female Sprague-Dawley and Spontaneously Hypertensive Rats Housed Singly or in Groups,” J. Am. Assoc. Lab. Anim. Sci. 50(2), 175–184 (2011).
[PubMed]

Bauer, A. Q.

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

Bauer, D. R.

L. G. Montilla, R. Olafsson, D. R. Bauer, and R. S. Witte, “Real-time photoacoustic and ultrasound imaging: a simple solution for clinical ultrasound systems with linear arrays,” Phys. Med. Biol. 58(1), N1–N12 (2013).
[Crossref] [PubMed]

Bay, E.

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

Beard, P.

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

Bernelot Moens, H. J.

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

Bhattacharyya, K.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Biswas, S. K.

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

Bitton, R.

Bodapati, S.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Brands, P.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

Bustamante, G.

H. Huang, G. Bustamante, R. Peterson, and J. Y. Ye, “An adaptive filtered back-projection for photoacoustic image reconstruction,” Med. Phys. 42(5), 2169–2178 (2015).
[Crossref] [PubMed]

Chen, B. Z.

Chen, S.

Chen, X.

W. Li and X. Chen, “Gold nanoparticles for photoacoustic imaging,” Nanomedicine (Lond.) 10(2), 299–320 (2015).
[Crossref] [PubMed]

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Cheng, J.-X.

Cheng, Z.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Culver, J. P.

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

Dai, H.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Daoudi, K.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

De la Zerda, A.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Deán-Ben, X. L.

X. L. Deán-Ben, S. J. Ford, and D. Razansky, “High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion,” Sci. Rep. 5, 10133 (2015).
[Crossref] [PubMed]

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

C. Lutzweiler, X. L. Deán-Ben, and D. Razansky, “Expediting model-based optoacoustic reconstructions with tomographic symmetries,” Med. Phys. 41(1), 013302 (2014).
[Crossref] [PubMed]

DeSouza, T.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Dima, A.

Diot, G.

Erpelding, T. N.

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

Favazza, C.

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

Ford, S. J.

X. L. Deán-Ben, S. J. Ford, and D. Razansky, “High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion,” Sci. Rep. 5, 10133 (2015).
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Galanzha, E. I.

E. I. Galanzha and V. P. Zharov, “Circulating tumor cell detection and capture by photoacoustic flow cytometry in vivo and ex vivo,” Cancers (Basel) 5(4), 1691–1738 (2013).
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Gambhir, S. S.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Gamelin, J.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

Goergen, C. J.

Goldschmidt, B. S.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
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M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, “Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent,” J. Biomed. Opt. 14(3), 034018 (2009).
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Guo, Z.

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

Gupta, S. K.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Heldermon, C. D.

X. Li, C. D. Heldermon, L. Yao, L. Xi, and H. Jiang, “High resolution functional photoacoustic tomography of breast cancer,” Med. Phys. 42(9), 5321–5328 (2015).
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L. V. Wang and S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
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Huang, C.

C. Huang, K. Wang, L. Nie, L. V. Wang, and M. A. Anastasio, “Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media,” IEEE Trans. Med. Imaging 32(6), 1097–1110 (2013).
[Crossref] [PubMed]

Huang, H.

H. Huang, G. Bustamante, R. Peterson, and J. Y. Ye, “An adaptive filtered back-projection for photoacoustic image reconstruction,” Med. Phys. 42(5), 2169–2178 (2015).
[Crossref] [PubMed]

Jankovic, L.

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
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Ji, L.

L. Xiang, B. Wang, L. Ji, and H. Jiang, “4-D photoacoustic tomography,” Sci. Rep. 3, 1113 (2013).
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Jiang, H.

X. Li, C. D. Heldermon, L. Yao, L. Xi, and H. Jiang, “High resolution functional photoacoustic tomography of breast cancer,” Med. Phys. 42(9), 5321–5328 (2015).
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L. Xiang, B. Wang, L. Ji, and H. Jiang, “4-D photoacoustic tomography,” Sci. Rep. 3, 1113 (2013).
[Crossref] [PubMed]

Jiang, H. B.

Keren, S.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Khuri-Yakub, B. T.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Kim, C.

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

Kneipp, M.

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

Kohl, A.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

Ku, G.

M. Pramanik, G. Ku, C. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[Crossref] [PubMed]

Lan, L.

Lauri, A.

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

Lawson, D.

T. Azar, J. Sharp, and D. Lawson, “Heart Rates of Male and Female Sprague-Dawley and Spontaneously Hypertensive Rats Housed Singly or in Groups,” J. Am. Assoc. Lab. Anim. Sci. 50(2), 175–184 (2011).
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Levi, J.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Li, C.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

M. Pramanik, G. Ku, C. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[Crossref] [PubMed]

Li, R.

Li, W.

W. Li and X. Chen, “Gold nanoparticles for photoacoustic imaging,” Nanomedicine (Lond.) 10(2), 299–320 (2015).
[Crossref] [PubMed]

Li, X.

X. Li, C. D. Heldermon, L. Yao, L. Xi, and H. Jiang, “High resolution functional photoacoustic tomography of breast cancer,” Med. Phys. 42(9), 5321–5328 (2015).
[Crossref] [PubMed]

Li, Z.-Y.

X. Yang, S. E. Skrabalak, Z.-Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent,” Nano Lett. 7(12), 3798–3802 (2007).
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Liu, Z.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Lloyd, F. P.

Lutzweiler, C.

C. Lutzweiler, X. L. Deán-Ben, and D. Razansky, “Expediting model-based optoacoustic reconstructions with tomographic symmetries,” Med. Phys. 41(1), 013302 (2014).
[Crossref] [PubMed]

Ma, T.-J.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Manohar, S.

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

W. Xia, D. Piras, M. K. A. Singh, J. C. G. van Hespen, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Design and evaluation of a laboratory prototype system for 3D photoacoustic full breast tomography,” Biomed. Opt. Express 4(11), 2555–2569 (2013).
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Margenthaler, J. A.

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

Maslov, K.

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

Maurudis, A.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

Montilla, L. G.

L. G. Montilla, R. Olafsson, D. R. Bauer, and R. S. Witte, “Real-time photoacoustic and ultrasound imaging: a simple solution for clinical ultrasound systems with linear arrays,” Phys. Med. Biol. 58(1), N1–N12 (2013).
[Crossref] [PubMed]

Mosley, J. D.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Nasiriavanaki, M.

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

Nie, L.

C. Huang, K. Wang, L. Nie, L. V. Wang, and M. A. Anastasio, “Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media,” IEEE Trans. Med. Imaging 32(6), 1097–1110 (2013).
[Crossref] [PubMed]

Ntziachristos, V.

A. Taruttis and V. Ntziachristos, “Advances in real-time multispectral optoacoustic imaging and its applications,” Nat. Photonics 9(4), 219–227 (2015).
[Crossref]

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

G. Diot, A. Dima, and V. Ntziachristos, “Multispectral opto-acoustic tomography of exercised muscle oxygenation,” Opt. Lett. 40(7), 1496–1499 (2015).
[Crossref] [PubMed]

O’Brien, C. M.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Olafsson, R.

L. G. Montilla, R. Olafsson, D. R. Bauer, and R. S. Witte, “Real-time photoacoustic and ultrasound imaging: a simple solution for clinical ultrasound systems with linear arrays,” Phys. Med. Biol. 58(1), N1–N12 (2013).
[Crossref] [PubMed]

Oralkan, O.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Pashley, M. D.

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

Peterson, R.

H. Huang, G. Bustamante, R. Peterson, and J. Y. Ye, “An adaptive filtered back-projection for photoacoustic image reconstruction,” Med. Phys. 42(5), 2169–2178 (2015).
[Crossref] [PubMed]

Piras, D.

Prakash, J.

Pramanik, M.

P. K. Upputuri and M. Pramanik, “Performance characterization of low-cost, high-speed, portable pulsed laser diode photoacoustic tomography (PLD-PAT) system,” Biomed. Opt. Express 6(10), 4118–4129 (2015).
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P. K. Upputuri and M. Pramanik, “Pulsed laser diode based optoacoustic imaging of biological tissues,” Biomed. Phys. Eng. Express 1(4), 045010 (2015).
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M. Pramanik, “Improving tangential resolution with a modified delay-and-sum reconstruction algorithm in photoacoustic and thermoacoustic tomography,” J. Opt. Soc. Am. A 31(3), 621–627 (2014).
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J. Prakash, A. S. Raju, C. B. Shaw, M. Pramanik, and P. K. Yalavarthy, “Basis pursuit deconvolution for improving model-based reconstructed images in photoacoustic tomography,” Biomed. Opt. Express 5(5), 1363–1377 (2014).
[Crossref] [PubMed]

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt. 14(5), 054024 (2009).
[Crossref] [PubMed]

M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, “Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent,” J. Biomed. Opt. 14(3), 034018 (2009).
[Crossref] [PubMed]

M. Pramanik, G. Ku, C. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[Crossref] [PubMed]

Rabot, O.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

Raju, A. S.

Razansky, D.

X. L. Deán-Ben, S. J. Ford, and D. Razansky, “High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion,” Sci. Rep. 5, 10133 (2015).
[Crossref] [PubMed]

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

X. L. Deán-Ben, E. Bay, and D. Razansky, “Functional optoacoustic imaging of moving objects using microsecond-delay acquisition of multispectral three-dimensional tomographic data,” Sci. Rep. 4, 5878 (2014).
[Crossref] [PubMed]

C. Lutzweiler, X. L. Deán-Ben, and D. Razansky, “Expediting model-based optoacoustic reconstructions with tomographic symmetries,” Med. Phys. 41(1), 013302 (2014).
[Crossref] [PubMed]

Rood, K. D.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Sela, G.

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

Sengupta, S.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Sharma, N.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Sharp, J.

T. Azar, J. Sharp, and D. Lawson, “Heart Rates of Male and Female Sprague-Dawley and Spontaneously Hypertensive Rats Housed Singly or in Groups,” J. Am. Assoc. Lab. Anim. Sci. 50(2), 175–184 (2011).
[PubMed]

Shaw, C. B.

Shoham, S.

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

Shung, K. K.

Singh, M. K. A.

Sitharaman, B.

M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, “Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent,” J. Biomed. Opt. 14(3), 034018 (2009).
[Crossref] [PubMed]

Skrabalak, S. E.

X. Yang, S. E. Skrabalak, Z.-Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent,” Nano Lett. 7(12), 3798–3802 (2007).
[Crossref] [PubMed]

Smith, B. R.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Song, L.

Steenbergen, W.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

W. Xia, D. Piras, M. K. A. Singh, J. C. G. van Hespen, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Design and evaluation of a laboratory prototype system for 3D photoacoustic full breast tomography,” Biomed. Opt. Express 4(11), 2555–2569 (2013).
[Crossref] [PubMed]

Swierczewska, M.

M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, “Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent,” J. Biomed. Opt. 14(3), 034018 (2009).
[Crossref] [PubMed]

Taruttis, A.

A. Taruttis and V. Ntziachristos, “Advances in real-time multispectral optoacoustic imaging and its applications,” Nat. Photonics 9(4), 219–227 (2015).
[Crossref]

Tisserand, S.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

Upputuri, P. K.

Vaithilingam, S.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

van den Berg, P. J.

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe integrating laser diode and ultrasound transducer array for ultrasound/photoacoustic dual modality imaging,” Opt. Express 22(21), 26365–26374 (2014).
[Crossref] [PubMed]

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

van Es, P.

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

van Hespen, J. C. G.

van Leeuwen, T. G.

Viator, J. A.

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

Wan, H.

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

Wang, B.

L. Xiang, B. Wang, L. Ji, and H. Jiang, “4-D photoacoustic tomography,” Sci. Rep. 3, 1113 (2013).
[Crossref] [PubMed]

Wang, K.

C. Huang, K. Wang, L. Nie, L. V. Wang, and M. A. Anastasio, “Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media,” IEEE Trans. Med. Imaging 32(6), 1097–1110 (2013).
[Crossref] [PubMed]

Wang, L. V.

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

C. Huang, K. Wang, L. Nie, L. V. Wang, and M. A. Anastasio, “Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media,” IEEE Trans. Med. Imaging 32(6), 1097–1110 (2013).
[Crossref] [PubMed]

L. V. Wang and S. Hu, “Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs,” Science 335(6075), 1458–1462 (2012).
[Crossref] [PubMed]

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt. 14(5), 054024 (2009).
[Crossref] [PubMed]

M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, “Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent,” J. Biomed. Opt. 14(3), 034018 (2009).
[Crossref] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys. 35(12), 5758–5767 (2008).
[Crossref] [PubMed]

M. Pramanik, G. Ku, C. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[Crossref] [PubMed]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer,” Opt. Express 16(11), 7915–7928 (2008).
[Crossref] [PubMed]

R. J. Zemp, L. Song, R. Bitton, K. K. Shung, and L. V. Wang, “Realtime photoacoustic microscopy of murine cardiovascular dynamics,” Opt. Express 16(22), 18551–18556 (2008).
[Crossref] [PubMed]

X. Yang, S. E. Skrabalak, Z.-Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent,” Nano Lett. 7(12), 3798–3802 (2007).
[Crossref] [PubMed]

Wang, P.

Westmeyer, G. G.

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

Witte, R. S.

L. G. Montilla, R. Olafsson, D. R. Bauer, and R. S. Witte, “Real-time photoacoustic and ultrasound imaging: a simple solution for clinical ultrasound systems with linear arrays,” Phys. Med. Biol. 58(1), N1–N12 (2013).
[Crossref] [PubMed]

Wu, D.

Xi, L.

X. Li, C. D. Heldermon, L. Yao, L. Xi, and H. Jiang, “High resolution functional photoacoustic tomography of breast cancer,” Med. Phys. 42(9), 5321–5328 (2015).
[Crossref] [PubMed]

Xia, J.

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

Xia, W.

Xia, Y.

X. Yang, S. E. Skrabalak, Z.-Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent,” Nano Lett. 7(12), 3798–3802 (2007).
[Crossref] [PubMed]

Xiang, L.

L. Xiang, B. Wang, L. Ji, and H. Jiang, “4-D photoacoustic tomography,” Sci. Rep. 3, 1113 (2013).
[Crossref] [PubMed]

Yalavarthy, P. K.

Yang, J. G.

Yang, N.

Yang, X.

X. Yang, S. E. Skrabalak, Z.-Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent,” Nano Lett. 7(12), 3798–3802 (2007).
[Crossref] [PubMed]

Yao, L.

X. Li, C. D. Heldermon, L. Yao, L. Xi, and H. Jiang, “High resolution functional photoacoustic tomography of breast cancer,” Med. Phys. 42(9), 5321–5328 (2015).
[Crossref] [PubMed]

Ye, J. Y.

H. Huang, G. Bustamante, R. Peterson, and J. Y. Ye, “An adaptive filtered back-projection for photoacoustic image reconstruction,” Med. Phys. 42(5), 2169–2178 (2015).
[Crossref] [PubMed]

Yi, Y.

Zavaleta, C.

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Zemp, R. J.

Zeng, D. W.

Zharov, V. P.

E. I. Galanzha and V. P. Zharov, “Circulating tumor cell detection and capture by photoacoustic flow cytometry in vivo and ex vivo,” Cancers (Basel) 5(4), 1691–1738 (2013).
[Crossref] [PubMed]

Zhu, Q.

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

arXiv preprint arXiv. (1)

G. Sela, A. Lauri, X. L. Deán-Ben, M. Kneipp, V. Ntziachristos, S. Shoham, G. G. Westmeyer, and D. Razansky, “Functional optoacoustic neuro-tomography (FONT) for whole-brain monitoring of calcium indicators,” arXiv preprint arXiv. 1501, 2450 (2015).

Biomed. Opt. Express (5)

Biomed. Phys. Eng. Express (1)

P. K. Upputuri and M. Pramanik, “Pulsed laser diode based optoacoustic imaging of biological tissues,” Biomed. Phys. Eng. Express 1(4), 045010 (2015).
[Crossref]

Cancers (Basel) (1)

E. I. Galanzha and V. P. Zharov, “Circulating tumor cell detection and capture by photoacoustic flow cytometry in vivo and ex vivo,” Cancers (Basel) 5(4), 1691–1738 (2013).
[Crossref] [PubMed]

Chem. Rev. (1)

C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110(5), 2756–2782 (2010).
[Crossref] [PubMed]

IEEE Trans. Med. Imaging (1)

C. Huang, K. Wang, L. Nie, L. V. Wang, and M. A. Anastasio, “Full-wave iterative image reconstruction in photoacoustic tomography with acoustically inhomogeneous media,” IEEE Trans. Med. Imaging 32(6), 1097–1110 (2013).
[Crossref] [PubMed]

Interface Focus (1)

P. Beard, “Biomedical photoacoustic imaging,” Interface Focus 1(4), 602–631 (2011).
[Crossref] [PubMed]

J. Am. Assoc. Lab. Anim. Sci. (1)

T. Azar, J. Sharp, and D. Lawson, “Heart Rates of Male and Female Sprague-Dawley and Spontaneously Hypertensive Rats Housed Singly or in Groups,” J. Am. Assoc. Lab. Anim. Sci. 50(2), 175–184 (2011).
[PubMed]

J. Biomed. Opt. (6)

C. M. O’Brien, K. D. Rood, K. Bhattacharyya, T. DeSouza, S. Sengupta, S. K. Gupta, J. D. Mosley, B. S. Goldschmidt, N. Sharma, and J. A. Viator, “Capture of circulating tumor cells using photoacoustic flowmetry and two phase flow,” J. Biomed. Opt. 17(6), 061221 (2012).
[Crossref] [PubMed]

C. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt. 15(1), 010509 (2010).
[Crossref] [PubMed]

M. Pramanik, M. Swierczewska, D. Green, B. Sitharaman, and L. V. Wang, “Single-walled carbon nanotubes as a multimodal-thermoacoustic and photoacoustic-contrast agent,” J. Biomed. Opt. 14(3), 034018 (2009).
[Crossref] [PubMed]

P. van Es, S. K. Biswas, H. J. Bernelot Moens, W. Steenbergen, and S. Manohar, “Initial results of finger imaging using photoacoustic computed tomography,” J. Biomed. Opt. 19(6), 060501 (2014).
[Crossref] [PubMed]

M. Pramanik and L. V. Wang, “Thermoacoustic and photoacoustic sensing of temperature,” J. Biomed. Opt. 14(5), 054024 (2009).
[Crossref] [PubMed]

C. Kim, T. N. Erpelding, K. Maslov, L. Jankovic, W. J. Akers, L. Song, S. Achilefu, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes,” J. Biomed. Opt. 15(4), 046010 (2010).
[Crossref] [PubMed]

J. Opt. Soc. Am. A (1)

Med. Phys. (5)

C. Lutzweiler, X. L. Deán-Ben, and D. Razansky, “Expediting model-based optoacoustic reconstructions with tomographic symmetries,” Med. Phys. 41(1), 013302 (2014).
[Crossref] [PubMed]

M. Pramanik, G. Ku, C. Li, and L. V. Wang, “Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography,” Med. Phys. 35(6), 2218–2223 (2008).
[Crossref] [PubMed]

H. Huang, G. Bustamante, R. Peterson, and J. Y. Ye, “An adaptive filtered back-projection for photoacoustic image reconstruction,” Med. Phys. 42(5), 2169–2178 (2015).
[Crossref] [PubMed]

X. Li, C. D. Heldermon, L. Yao, L. Xi, and H. Jiang, “High resolution functional photoacoustic tomography of breast cancer,” Med. Phys. 42(9), 5321–5328 (2015).
[Crossref] [PubMed]

L. V. Wang, “Prospects of photoacoustic tomography,” Med. Phys. 35(12), 5758–5767 (2008).
[Crossref] [PubMed]

Nano Lett. (1)

X. Yang, S. E. Skrabalak, Z.-Y. Li, Y. Xia, and L. V. Wang, “Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent,” Nano Lett. 7(12), 3798–3802 (2007).
[Crossref] [PubMed]

Nanomedicine (Lond.) (1)

W. Li and X. Chen, “Gold nanoparticles for photoacoustic imaging,” Nanomedicine (Lond.) 10(2), 299–320 (2015).
[Crossref] [PubMed]

Nat. Nanotechnol. (1)

A. De la Zerda, C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, B. R. Smith, T.-J. Ma, O. Oralkan, Z. Cheng, X. Chen, H. Dai, B. T. Khuri-Yakub, and S. S. Gambhir, “Carbon nanotubes as photoacoustic molecular imaging agents in living mice,” Nat. Nanotechnol. 3(9), 557–562 (2008).
[Crossref] [PubMed]

Nat. Photonics (2)

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

A. Taruttis and V. Ntziachristos, “Advances in real-time multispectral optoacoustic imaging and its applications,” Nat. Photonics 9(4), 219–227 (2015).
[Crossref]

Opt. Express (3)

Opt. Lett. (1)

Phys. Med. Biol. (1)

L. G. Montilla, R. Olafsson, D. R. Bauer, and R. S. Witte, “Real-time photoacoustic and ultrasound imaging: a simple solution for clinical ultrasound systems with linear arrays,” Phys. Med. Biol. 58(1), N1–N12 (2013).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (1)

M. Nasiriavanaki, J. Xia, H. Wan, A. Q. Bauer, J. P. Culver, and L. V. Wang, “High-resolution photoacoustic tomography of resting-state functional connectivity in the mouse brain,” Proc. Natl. Acad. Sci. U.S.A. 111(1), 21–26 (2014).
[Crossref] [PubMed]

Proc. SPIE (1)

K. Daoudi, P. J. van den Berg, O. Rabot, A. Kohl, S. Tisserand, P. Brands, and W. Steenbergen, “Handheld probe for portable high frame photoacoustic/ultrasound imaging system,” Proc. SPIE 8581, 85812I (2013).
[Crossref]

Radiology (1)

T. N. Erpelding, C. Kim, M. Pramanik, L. Jankovic, K. Maslov, Z. Guo, J. A. Margenthaler, M. D. Pashley, and L. V. Wang, “Sentinel lymph nodes in the rat: noninvasive photoacoustic and US imaging with a clinical US system,” Radiology 256(1), 102–110 (2010).
[Crossref] [PubMed]

Sci. Rep. (3)

L. Xiang, B. Wang, L. Ji, and H. Jiang, “4-D photoacoustic tomography,” Sci. Rep. 3, 1113 (2013).
[Crossref] [PubMed]

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Science (1)

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Supplementary Material (8)

NameDescription
» Visualization 1: MP4 (8721 KB)      movie clip for 3 cm/s flow rate with 3500 fps
» Visualization 2: MP4 (5168 KB)      movie clip for 6 cm/s flow rate with 3500 fps
» Visualization 3: MP4 (4133 KB)      movie clip for 10 cm/s flow rate with 3500 fps
» Visualization 4: MP4 (3380 KB)      movie clip for 14 cm/s flow rate with 3500 fps
» Visualization 5: MP4 (11371 KB)      movie clip for 3 cm/s flow rate with 7000 fps
» Visualization 6: MP4 (6859 KB)      movie clip for 6 cm/s flow rate with 7000 fps
» Visualization 7: MP4 (4376 KB)      movie clip for 10 cm/s flow rate with 7000 fps
» Visualization 8: MP4 (3742 KB)      movie clip for 14 cm/s flow rate with 7000 fps

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Figures (5)

Fig. 1
Fig. 1 a) Schematic of the PLD-PAT ultrasound setup; PLD: Pulsed laser diode, UST: ultrasound array transducer, CL: cylindrical lens, SP: syringe pump, LDU: laser driver unit, USM: clinical ultrasound machine. b) Image showing all the components of the PLD-PAT imaging setup for flow imaging. c) The L3-12 linear array ultrasound transducer which can be operated in 2 different modes. One using all the 128 arrays elements, and the other using 64 channels elements only (element numbers 1-64 or 65-128).
Fig. 2
Fig. 2 Ultrasound B-mode image on the ECUBE system showing the flow of the black ink inside the tube. The enlarged tube region shows that we can see the boundary of the tube, but no flow can be visible in the ultrasound images, as ink does not have a good ultrasound contrast.
Fig. 3
Fig. 3 Set of PA images showing the ink flow at various time points obtained with PLD-PAT system. PA imaging was done at a frame rate of 3500 fps. Schematic of the setup is shown on the top. (a-d) Flow rate was 3 cm/s, (e-h) flow rate was 14 cm/s. All images have same scale bars shown in (a). The normalised colormap is shown on the right. Movie clips (Visualization 1, Visualization 2, Visualization 3, and Visualization 4) show the ink flowing through the tube with 3500 fps PA B-scan imaging.
Fig. 4
Fig. 4 Set of PA images showing the ink flow at various time points with the PLD-PAT system. PA imaging was done at a frame rate of 7000 fps. (a-d) Flow rate was 3 cm/s, (e-h) flow rate was 14 cm/s. All images have same scale bar shown in (a). The normalized colormap is shown on the right. Movie clips (Visualization 5, Visualization 6, Visualization 7, and Visualization 8) show the ink flowing through the tube with 7000 fps PA B-scan imaging.
Fig. 5
Fig. 5 Set of PA images showing the ink flow at various time points as obtained by OPO-PAT system. (a-d) PA imaging was done at a frame rate of 5 fps and (e-h) at a frame rate of 10 fps. (a,b,e,f) Flow rate was 3 cm/s, (c,d,g,h) flow rate was 14 cm/s. All the images have same scale bars as shown in (a). The normalized colormap is shown on the right.

Tables (1)

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Table 1 Comparison of the flow rates as controlled from the syringe pump and measured from the PA images from the PLD-PAT system

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