Abstract

Current optical coherence tomography (OCT) imaging suffers from short ranging distance and narrow imaging field of view (FOV). There is growing interest in searching for solutions to these limitations in order to expand further in vivo OCT applications. This paper describes a solution where we utilize an akinetic swept source for OCT implementation to enable ~10 cm ranging distance, associated with the use of a wide-angle camera lens in the sample arm to provide a FOV of ~20 x 20 cm2. The akinetic swept source operates at 1300 nm central wavelength with a bandwidth of 100 nm. We propose an adaptive calibration procedure to the programmable akinetic light source so that the sensitivity of the OCT system over ~10 cm ranging distance is substantially improved for imaging of large volume samples. We demonstrate the proposed swept source OCT system for in vivo imaging of entire human hands and faces with an unprecedented FOV (up to 400 cm2). The capability of large-volume OCT imaging with ultra-long ranging and ultra-wide FOV is expected to bring new opportunities for in vivo biomedical applications.

© 2016 Optical Society of America

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    [Crossref] [PubMed]

2016 (3)

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
[Crossref] [PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

2015 (2)

2014 (3)

2013 (1)

2012 (2)

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G. Fujimoto, “Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with vertical-cavity surface emitting lasers,” Biomed. Opt. Express 3(11), 2733–2751 (2012).
[Crossref] [PubMed]

2011 (3)

2010 (2)

W. Y. Oh, B. J. Vakoc, M. Shishkov, G. J. Tearney, and B. E. Bouma, “>400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging,” Opt. Lett. 35(17), 2919–2921 (2010).
[Crossref] [PubMed]

Y. Jia and R. K. Wang, “Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in mice,” J. Neurosci. Methods 194(1), 108–115 (2010).
[Crossref] [PubMed]

2009 (1)

2007 (1)

R. K. Wang, “In vivo full range complex Fourier domain optical coherence tomography,” Appl. Phys. Lett. 90(5), 054103 (2007).
[Crossref] [PubMed]

2006 (1)

2005 (1)

P. H. Tomlins and R. Wang, “Theory, developments and applications of optical coherence tomography,” J. Phys. D Appl. Phys. 38(15), 2519–2535 (2005).
[Crossref]

2003 (1)

1997 (1)

1991 (2)

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

D. H. Bailey and P. N. Swarztrauber, “The fractional Fourier transform and applications,” SIAM Rev. 33(3), 389–404 (1991).
[Crossref]

Adler, D. C.

Bailey, D. H.

D. H. Bailey and P. N. Swarztrauber, “The fractional Fourier transform and applications,” SIAM Rev. 33(3), 389–404 (1991).
[Crossref]

Baran, U.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Biedermann, B. R.

Bonesi, M.

Boschert, P.

Bouma, B. E.

Cable, A. E.

Chang, W.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Chinn, S. R.

Choma, M.

Crawford, M.

Drexler, W.

Duker, J. S.

Eigenwillig, C. M.

Ensher, J.

Flotte, T.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Folio, L. S.

M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
[Crossref] [PubMed]

Fujimoto, J. G.

Fujiura, K.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Gabriele, M. L.

M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
[Crossref] [PubMed]

Goldberg, B. D.

Gregory, K.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Grulkowski, I.

Haruna, M.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Hee, M. R.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Hoover, E.

Hsieh, B.-Y.

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
[Crossref] [PubMed]

Huang, D.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Huber, R.

Huber, R. A.

Ishikawa, H.

M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
[Crossref] [PubMed]

Izatt, J.

Jayaraman, V.

Jia, Y.

Y. Jia and R. K. Wang, “Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in mice,” J. Neurosci. Methods 194(1), 108–115 (2010).
[Crossref] [PubMed]

Jiang, J.

Jillella, P.

Johnstone, M.

P. Li, M. Johnstone, and R. K. Wang, “Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm,” J. Biomed. Opt. 19(4), 046013 (2014).
[Crossref] [PubMed]

Kagemann, L.

M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
[Crossref] [PubMed]

Klein, T.

Kobayashi, J.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Kolb, J. P.

Kufner, C. L.

Leitgeb, R. A.

Li, P.

P. Li, M. Johnstone, and R. K. Wang, “Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm,” J. Biomed. Opt. 19(4), 046013 (2014).
[Crossref] [PubMed]

Lin, C. P.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Liu, J. J.

Lu, C. D.

Minneman, M. P.

Motaghian Nezam, S. M.

Naganuma, K.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Neubauer, A. S.

O’Donnell, M.

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
[Crossref] [PubMed]

Oh, W. Y.

Ohmi, M.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Okabe, Y.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Omiya, K.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Pelivanov, I.

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
[Crossref] [PubMed]

Potsaid, B.

Puliafito, C. A.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Qi, X.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

Qin, W.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

Sakai, Y.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Sakamoto, T.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Sarunic, M.

Sasaki, Y.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Sattmann, H.

Schmitt, J. M.

Schuman, J. S.

M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Shen, T. T.

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
[Crossref] [PubMed]

Shishkov, M.

Song, S.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
[Crossref] [PubMed]

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

Stinson, W. G.

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Swanson, E. A.

S. R. Chinn, E. A. Swanson, and J. G. Fujimoto, “Optical coherence tomography using a frequency-tunable optical source,” Opt. Lett. 22(5), 340–342 (1997).
[Crossref] [PubMed]

D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
[Crossref] [PubMed]

Swarztrauber, P. N.

D. H. Bailey and P. N. Swarztrauber, “The fractional Fourier transform and applications,” SIAM Rev. 33(3), 389–404 (1991).
[Crossref]

Tearney, G. J.

Tomlins, P. H.

P. H. Tomlins and R. Wang, “Theory, developments and applications of optical coherence tomography,” J. Phys. D Appl. Phys. 38(15), 2519–2535 (2005).
[Crossref]

Toyoda, S.

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Tsia, K. K.

Ueno, M.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
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Wang, R. K.

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
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W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
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J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
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P. Li, M. Johnstone, and R. K. Wang, “Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm,” J. Biomed. Opt. 19(4), 046013 (2014).
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Wei, W.

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
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J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
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Wieser, W.

Wojtkowski, M.

Wollstein, G.

M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
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Xu, J.

J. Xu, W. Wei, S. Song, X. Qi, and R. K. Wang, “Scalable wide-field optical coherence tomography-based angiography for in vivo imaging applications,” Biomed. Opt. Express 7(5), 1905–1919 (2016).
[Crossref] [PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
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J. Xu, X. Wei, L. Yu, C. Zhang, J. Xu, K. K. Wong, and K. K. Tsia, “High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch,” Biomed. Opt. Express 6(4), 1340–1350 (2015).
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J. Xu, X. Wei, L. Yu, C. Zhang, J. Xu, K. K. Wong, and K. K. Tsia, “High-performance multi-megahertz optical coherence tomography based on amplified optical time-stretch,” Biomed. Opt. Express 6(4), 1340–1350 (2015).
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J. Xu, C. Zhang, J. Xu, K. K. Wong, and K. K. Tsia, “Megahertz all-optical swept-source optical coherence tomography based on broadband amplified optical time-stretch,” Opt. Lett. 39(3), 622–625 (2014).
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M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
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Yagi, S.

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
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Appl. Phys. Lett. (2)

R. K. Wang, “In vivo full range complex Fourier domain optical coherence tomography,” Appl. Phys. Lett. 90(5), 054103 (2007).
[Crossref] [PubMed]

S. Song, W. Wei, B.-Y. Hsieh, I. Pelivanov, T. T. Shen, M. O’Donnell, and R. K. Wang, “Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate,” Appl. Phys. Lett. 108(19), 191104 (2016).
[Crossref] [PubMed]

Biomed. Opt. Express (4)

Electron. Lett. (1)

Y. Okabe, Y. Sasaki, M. Ueno, T. Sakamoto, S. Toyoda, S. Yagi, K. Naganuma, K. Fujiura, Y. Sakai, J. Kobayashi, K. Omiya, M. Ohmi, and M. Haruna, “200 kHz swept light source equipped with KTN deflector for optical coherence tomography,” Electron. Lett. 48(4), 201–202 (2012).
[Crossref]

Invest. Ophthalmol. Vis. Sci. (1)

M. L. Gabriele, G. Wollstein, H. Ishikawa, L. Kagemann, J. Xu, L. S. Folio, and J. S. Schuman, “Optical coherence tomography: history, current status, and laboratory work,” Invest. Ophthalmol. Vis. Sci. 52(5), 2425–2436 (2011).
[Crossref] [PubMed]

J. Biomed. Opt. (2)

P. Li, M. Johnstone, and R. K. Wang, “Full anterior segment biometry with extended imaging range spectral domain optical coherence tomography at 1340 nm,” J. Biomed. Opt. 19(4), 046013 (2014).
[Crossref] [PubMed]

W. Wei, J. Xu, U. Baran, S. Song, W. Qin, X. Qi, and R. K. Wang, “Intervolume analysis to achieve four-dimensional optical microangiography for observation of dynamic blood flow,” J. Biomed. Opt. 21(3), 036005 (2016).
[Crossref] [PubMed]

J. Neurosci. Methods (1)

Y. Jia and R. K. Wang, “Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in mice,” J. Neurosci. Methods 194(1), 108–115 (2010).
[Crossref] [PubMed]

J. Phys. D Appl. Phys. (1)

P. H. Tomlins and R. Wang, “Theory, developments and applications of optical coherence tomography,” J. Phys. D Appl. Phys. 38(15), 2519–2535 (2005).
[Crossref]

Opt. Express (6)

Opt. Lett. (4)

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D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, “Optical Coherence Tomography,” Science 254(5035), 1178–1181 (1991).
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Figures (9)

Fig. 1
Fig. 1 Schematic of the experimental setup for UW-OCT system. Lower left insert indicates measured spectrum of the akinetic light source running at 100 kHz.
Fig. 2
Fig. 2 PSF roll-off and resolution performance without calibration with an A/D sampling rate at 3.2 GHz. PSFs measured at each optical delay are plotted with different color; Dotted line with circle markers shows the corresponding axial resolution measured by the FWHM of the PSFs.
Fig. 3
Fig. 3 Performance assessments when the calibration is only performed at a single depth (frequency) position. (a) 3 selected PSF measurements around 480 MHz, with no calibration, and (b) corresponding PSF measurements with calibration at 480 MHz. (c) The PSF measurement over the entire depth of 1.6 GHz when the system was calibrated at 480 MHz position only. (d) The same as in (c) but the calibration was performed at 780 MHz. (e) and (f) are the zoomed view of PSF measurements as indicated in (c).
Fig. 4
Fig. 4 Sensitivity roll-off and resolution measurement of the akinetic SS-OCT system, after adaptive calibration.
Fig. 5
Fig. 5 2D cross-section OCT images of a multilayer tape and the corresponding zoom-in images next to it at varied depth positions as shown with (top row) and without (bottom row) calibration procedures, respectively.
Fig. 6
Fig. 6 A front view of the 3D OCT image rendering of human hand captured within ~2.5 sec. The size of the image is 12 cm (vertical) x 20 cm (horizontal).
Fig. 7
Fig. 7 The 2D cross-sectional images at the position marked by (a) the red dashed line and (b) the yellow dashed line in Fig. 6. (c) The zoom-in cross-sectional image in the area of middle finger as indicated in the green box in (a). (d) The zoom-in cross-sectional image in area of palm as indicated in the blue box in (b). ODM: opponens digiti minimi, OP: opponens pollicis, E: epidermis, D: dermis, SBV: small blood vessels, LBV: large blood vessel.
Fig. 8
Fig. 8 OCT portraits of (a) a glass wearing young man with neutral expression and (b) another young man with mouth open. The size of the portraits is 21 cm (vertical) x 18 cm (horizontal).
Fig. 9
Fig. 9 (a) The cross-sectional image at the position of human eye as marked by the green dashed line in Fig. 8(a). (b) The cross-sectional image at the position of human mouth as marked by blue dashed line in Fig. 8(b).

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