Abstract

There have recently been several studies published involving terahertz (THz) imaging of frozen biomedical samples. In this paper, we investigate the effects of the freeze-thaw cycle on THz properties of porcine muscle and fat samples. For ordinary freezing, there was a significant change in the THz properties after thawing for muscle tissue but not for fat tissue. However, if snap-freezing was combined with fast-thawing instead of ordinary freezing and ordinary thawing, then the freeze-thaw hysteresis was removed.

© 2016 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Tyler Bowman, Magda El-Shenawee, and Lucas K. Campbell
Biomed. Opt. Express 7(9) 3756-3783 (2016)

Composite multiscale entropy analysis of reflective terahertz signals for biological tissues

Rui Zhang, Yuezhi He, Kai Liu, Liangliang Zhang, Shijing Zhang, Emma Pickwell-MacPherson, Yuejin Zhao, and Cunlin Zhang
Opt. Express 25(20) 23669-23676 (2017)

Terahertz imaging of excised oral cancer at frozen temperature

Yookyeong Carolyn Sim, Jae Yeon Park, Kang-Min Ahn, Chansik Park, and Joo-Hiuk Son
Biomed. Opt. Express 4(8) 1413-1421 (2013)

References

  • View by:
  • |
  • |
  • |

  1. S. Fan, Y. He, B. S. Ung, and E. Pickwell-MacPherson, “The growth of biomedical terahertz research,” J. Phys. D Appl. Phys. 47(37), 374009 (2014).
    [Crossref]
  2. R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
    [Crossref] [PubMed]
  3. V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
    [Crossref] [PubMed]
  4. V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, “Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma,” Appl. Spectrosc. 60(10), 1127–1133 (2006).
    [Crossref] [PubMed]
  5. R. H. J. Daniel, M. Mittleman, and M. C. Nuss, “T-ray imaging,” IEEE J. Sel. Top. Quantum Electron. 2, 679–692 (1996).
  6. E. Castro-Camus, M. Palomar, and A. A. Covarrubias, “Leaf water dynamics of Arabidopsis thaliana monitored in-vivo using terahertz time-domain spectroscopy,” Sci. Rep. 3, 2910 (2013).
    [Crossref] [PubMed]
  7. D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
    [Crossref] [PubMed]
  8. E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
    [Crossref] [PubMed]
  9. S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
    [Crossref] [PubMed]
  10. S. Fan, B. Ung, E. P. Parrott, and E. Pickwell-MacPherson, “Gelatin embedding: a novel way to preserve biological samples for terahertz imaging and spectroscopy,” Phys. Med. Biol. 60(7), 2703–2713 (2015).
    [Crossref] [PubMed]
  11. G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
    [Crossref] [PubMed]
  12. Y. Sun, B. M. Fischer, and E. Pickwell-MacPherson, “Effects of formalin fixing on the terahertz properties of biological tissues,” J. Biomed. Opt. 14(6), 064017 (2009).
    [Crossref] [PubMed]
  13. H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
    [Crossref]
  14. Y. C. Sim, J. Y. Park, K. M. Ahn, C. Park, and J. H. Son, “Terahertz imaging of excised oral cancer at frozen temperature,” Biomed. Opt. Express 4(8), 1413–1421 (2013).
    [Crossref] [PubMed]
  15. B. Li and D. W. Sun, “Effect of power ultrasound on freezing rate during immersion freezing of potatoes,” J. Food Eng. 55(3), 277–282 (2002).
    [Crossref]
  16. S. Fan, E. P. J. Parrott, B. S. Y. Ung, and E. Pickwell-MacPherson, “Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry,” Photonics Research 4(3), A29 (2016).
    [Crossref]
  17. S. Huang, P. C. Ashworth, K. W. Kan, Y. Chen, V. P. Wallace, Y. T. Zhang, and E. Pickwell-MacPherson, “Improved sample characterization in terahertz reflection imaging and spectroscopy,” Opt. Express 17(5), 3848–3854 (2009).
    [Crossref] [PubMed]
  18. MathWorks, “Detecting a Cell Using Image Segmentation” (2016), retrieved https://www.mathworks.com/help/images/examples/detecting-a-cell-using-image-segmentation.html .
  19. D. E. Pegg, “The relevance of ice crystal formation for the cryopreservation of tissues and organs,” Cryobiology 60(3Suppl), S36–S44 (2010).
    [Crossref] [PubMed]
  20. H. Kiani and D.-W. Sun, “Water crystallization and its importance to freezing of foods: A review,” Trends Food Sci. Technol. 22(8), 407–426 (2011).
    [Crossref]
  21. F. L. Curzon, “The Leidenfrost phenomenon,” Am. J. Phys. 46(8), 825 (1978).
    [Crossref]

2016 (1)

S. Fan, E. P. J. Parrott, B. S. Y. Ung, and E. Pickwell-MacPherson, “Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry,” Photonics Research 4(3), A29 (2016).
[Crossref]

2015 (1)

S. Fan, B. Ung, E. P. Parrott, and E. Pickwell-MacPherson, “Gelatin embedding: a novel way to preserve biological samples for terahertz imaging and spectroscopy,” Phys. Med. Biol. 60(7), 2703–2713 (2015).
[Crossref] [PubMed]

2014 (1)

S. Fan, Y. He, B. S. Ung, and E. Pickwell-MacPherson, “The growth of biomedical terahertz research,” J. Phys. D Appl. Phys. 47(37), 374009 (2014).
[Crossref]

2013 (2)

E. Castro-Camus, M. Palomar, and A. A. Covarrubias, “Leaf water dynamics of Arabidopsis thaliana monitored in-vivo using terahertz time-domain spectroscopy,” Sci. Rep. 3, 2910 (2013).
[Crossref] [PubMed]

Y. C. Sim, J. Y. Park, K. M. Ahn, C. Park, and J. H. Son, “Terahertz imaging of excised oral cancer at frozen temperature,” Biomed. Opt. Express 4(8), 1413–1421 (2013).
[Crossref] [PubMed]

2011 (1)

H. Kiani and D.-W. Sun, “Water crystallization and its importance to freezing of foods: A review,” Trends Food Sci. Technol. 22(8), 407–426 (2011).
[Crossref]

2010 (2)

D. E. Pegg, “The relevance of ice crystal formation for the cryopreservation of tissues and organs,” Cryobiology 60(3Suppl), S36–S44 (2010).
[Crossref] [PubMed]

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

2009 (3)

S. Huang, P. C. Ashworth, K. W. Kan, Y. Chen, V. P. Wallace, Y. T. Zhang, and E. Pickwell-MacPherson, “Improved sample characterization in terahertz reflection imaging and spectroscopy,” Opt. Express 17(5), 3848–3854 (2009).
[Crossref] [PubMed]

Y. Sun, B. M. Fischer, and E. Pickwell-MacPherson, “Effects of formalin fixing on the terahertz properties of biological tissues,” J. Biomed. Opt. 14(6), 064017 (2009).
[Crossref] [PubMed]

H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
[Crossref]

2008 (1)

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

2006 (2)

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, “Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma,” Appl. Spectrosc. 60(10), 1127–1133 (2006).
[Crossref] [PubMed]

2004 (1)

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

2003 (2)

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

2002 (1)

B. Li and D. W. Sun, “Effect of power ultrasound on freezing rate during immersion freezing of potatoes,” J. Food Eng. 55(3), 277–282 (2002).
[Crossref]

1996 (1)

R. H. J. Daniel, M. Mittleman, and M. C. Nuss, “T-ray imaging,” IEEE J. Sel. Top. Quantum Electron. 2, 679–692 (1996).

1978 (1)

F. L. Curzon, “The Leidenfrost phenomenon,” Am. J. Phys. 46(8), 825 (1978).
[Crossref]

Abbott, D.

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

Ahn, K. M.

Ahuja, A. T.

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

Ali, S.

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

Arnone, D.

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

Arnone, D. D.

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Ashworth, P. C.

Castro-Camus, E.

E. Castro-Camus, M. Palomar, and A. A. Covarrubias, “Leaf water dynamics of Arabidopsis thaliana monitored in-vivo using terahertz time-domain spectroscopy,” Sci. Rep. 3, 2910 (2013).
[Crossref] [PubMed]

Chen, Y.

Choi, J. W.

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

Cluff, J.

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

Cole, B.

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

Cole, B. E.

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Covarrubias, A. A.

E. Castro-Camus, M. Palomar, and A. A. Covarrubias, “Leaf water dynamics of Arabidopsis thaliana monitored in-vivo using terahertz time-domain spectroscopy,” Sci. Rep. 3, 2910 (2013).
[Crossref] [PubMed]

Crawley, D.

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

Curzon, F. L.

F. L. Curzon, “The Leidenfrost phenomenon,” Am. J. Phys. 46(8), 825 (1978).
[Crossref]

Daniel, R. H. J.

R. H. J. Daniel, M. Mittleman, and M. C. Nuss, “T-ray imaging,” IEEE J. Sel. Top. Quantum Electron. 2, 679–692 (1996).

Fan, S.

S. Fan, E. P. J. Parrott, B. S. Y. Ung, and E. Pickwell-MacPherson, “Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry,” Photonics Research 4(3), A29 (2016).
[Crossref]

S. Fan, B. Ung, E. P. Parrott, and E. Pickwell-MacPherson, “Gelatin embedding: a novel way to preserve biological samples for terahertz imaging and spectroscopy,” Phys. Med. Biol. 60(7), 2703–2713 (2015).
[Crossref] [PubMed]

S. Fan, Y. He, B. S. Ung, and E. Pickwell-MacPherson, “The growth of biomedical terahertz research,” J. Phys. D Appl. Phys. 47(37), 374009 (2014).
[Crossref]

Fischer, B. M.

Y. Sun, B. M. Fischer, and E. Pickwell-MacPherson, “Effects of formalin fixing on the terahertz properties of biological tissues,” J. Biomed. Opt. 14(6), 064017 (2009).
[Crossref] [PubMed]

Fitzgerald, A. J.

V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, “Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma,” Appl. Spectrosc. 60(10), 1127–1133 (2006).
[Crossref] [PubMed]

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

Flanagan, N.

V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, “Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma,” Appl. Spectrosc. 60(10), 1127–1133 (2006).
[Crossref] [PubMed]

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

Ha, T.

Hayashi, A.

H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
[Crossref]

He, Y.

S. Fan, Y. He, B. S. Ung, and E. Pickwell-MacPherson, “The growth of biomedical terahertz research,” J. Phys. D Appl. Phys. 47(37), 374009 (2014).
[Crossref]

Hoshina, H.

H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
[Crossref]

Huang, S.

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

S. Huang, P. C. Ashworth, K. W. Kan, Y. Chen, V. P. Wallace, Y. T. Zhang, and E. Pickwell-MacPherson, “Improved sample characterization in terahertz reflection imaging and spectroscopy,” Opt. Express 17(5), 3848–3854 (2009).
[Crossref] [PubMed]

Kan, K. W.

Kiani, H.

H. Kiani and D.-W. Sun, “Water crystallization and its importance to freezing of foods: A review,” Trends Food Sci. Technol. 22(8), 407–426 (2011).
[Crossref]

Li, B.

B. Li and D. W. Sun, “Effect of power ultrasound on freezing rate during immersion freezing of potatoes,” J. Food Eng. 55(3), 277–282 (2002).
[Crossref]

Linfield, E. H.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Longbottom, C.

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

Lynch, R. J.

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

Mickan, S. P.

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

Mittleman, M.

R. H. J. Daniel, M. Mittleman, and M. C. Nuss, “T-ray imaging,” IEEE J. Sel. Top. Quantum Electron. 2, 679–692 (1996).

Miyamaru, F.

H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
[Crossref]

Miyoshi, N.

H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
[Crossref]

Ng, B. W.

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

Nuss, M. C.

R. H. J. Daniel, M. Mittleman, and M. C. Nuss, “T-ray imaging,” IEEE J. Sel. Top. Quantum Electron. 2, 679–692 (1996).

Otani, C.

H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
[Crossref]

Palomar, M.

E. Castro-Camus, M. Palomar, and A. A. Covarrubias, “Leaf water dynamics of Arabidopsis thaliana monitored in-vivo using terahertz time-domain spectroscopy,” Sci. Rep. 3, 2910 (2013).
[Crossref] [PubMed]

Park, C.

Park, J. Y.

Parrott, E. P.

S. Fan, B. Ung, E. P. Parrott, and E. Pickwell-MacPherson, “Gelatin embedding: a novel way to preserve biological samples for terahertz imaging and spectroscopy,” Phys. Med. Biol. 60(7), 2703–2713 (2015).
[Crossref] [PubMed]

Parrott, E. P. J.

S. Fan, E. P. J. Parrott, B. S. Y. Ung, and E. Pickwell-MacPherson, “Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry,” Photonics Research 4(3), A29 (2016).
[Crossref]

Pegg, D. E.

D. E. Pegg, “The relevance of ice crystal formation for the cryopreservation of tissues and organs,” Cryobiology 60(3Suppl), S36–S44 (2010).
[Crossref] [PubMed]

Pepper, M.

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Pickwell, E.

V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, “Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma,” Appl. Spectrosc. 60(10), 1127–1133 (2006).
[Crossref] [PubMed]

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

Pickwell-MacPherson, E.

S. Fan, E. P. J. Parrott, B. S. Y. Ung, and E. Pickwell-MacPherson, “Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry,” Photonics Research 4(3), A29 (2016).
[Crossref]

S. Fan, B. Ung, E. P. Parrott, and E. Pickwell-MacPherson, “Gelatin embedding: a novel way to preserve biological samples for terahertz imaging and spectroscopy,” Phys. Med. Biol. 60(7), 2703–2713 (2015).
[Crossref] [PubMed]

S. Fan, Y. He, B. S. Ung, and E. Pickwell-MacPherson, “The growth of biomedical terahertz research,” J. Phys. D Appl. Phys. 47(37), 374009 (2014).
[Crossref]

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

Y. Sun, B. M. Fischer, and E. Pickwell-MacPherson, “Effects of formalin fixing on the terahertz properties of biological tissues,” J. Biomed. Opt. 14(6), 064017 (2009).
[Crossref] [PubMed]

S. Huang, P. C. Ashworth, K. W. Kan, Y. Chen, V. P. Wallace, Y. T. Zhang, and E. Pickwell-MacPherson, “Improved sample characterization in terahertz reflection imaging and spectroscopy,” Opt. Express 17(5), 3848–3854 (2009).
[Crossref] [PubMed]

Png, G. M.

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

Pye, R.

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

Pye, R. J.

V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, “Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma,” Appl. Spectrosc. 60(10), 1127–1133 (2006).
[Crossref] [PubMed]

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Shankar, S.

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

Sim, Y. C.

Son, J. H.

Sun, D. W.

B. Li and D. W. Sun, “Effect of power ultrasound on freezing rate during immersion freezing of potatoes,” J. Food Eng. 55(3), 277–282 (2002).
[Crossref]

Sun, D.-W.

H. Kiani and D.-W. Sun, “Water crystallization and its importance to freezing of foods: A review,” Trends Food Sci. Technol. 22(8), 407–426 (2011).
[Crossref]

Sun, Y.

Y. Sun, B. M. Fischer, and E. Pickwell-MacPherson, “Effects of formalin fixing on the terahertz properties of biological tissues,” J. Biomed. Opt. 14(6), 064017 (2009).
[Crossref] [PubMed]

Sy, S.

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

Taday, P. F.

Ung, B.

S. Fan, B. Ung, E. P. Parrott, and E. Pickwell-MacPherson, “Gelatin embedding: a novel way to preserve biological samples for terahertz imaging and spectroscopy,” Phys. Med. Biol. 60(7), 2703–2713 (2015).
[Crossref] [PubMed]

Ung, B. S.

S. Fan, Y. He, B. S. Ung, and E. Pickwell-MacPherson, “The growth of biomedical terahertz research,” J. Phys. D Appl. Phys. 47(37), 374009 (2014).
[Crossref]

Ung, B. S. Y.

S. Fan, E. P. J. Parrott, B. S. Y. Ung, and E. Pickwell-MacPherson, “Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry,” Photonics Research 4(3), A29 (2016).
[Crossref]

Wallace, V. P.

S. Huang, P. C. Ashworth, K. W. Kan, Y. Chen, V. P. Wallace, Y. T. Zhang, and E. Pickwell-MacPherson, “Improved sample characterization in terahertz reflection imaging and spectroscopy,” Opt. Express 17(5), 3848–3854 (2009).
[Crossref] [PubMed]

V. P. Wallace, A. J. Fitzgerald, E. Pickwell, R. J. Pye, P. F. Taday, N. Flanagan, and T. Ha, “Terahertz Pulsed Spectroscopy of Human Basal Cell Carcinoma,” Appl. Spectrosc. 60(10), 1127–1133 (2006).
[Crossref] [PubMed]

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

Wang, Y. X.

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

Woodward, R. M.

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

Yu, J.

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

Zhang, X. C.

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

Zhang, Y. T.

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

S. Huang, P. C. Ashworth, K. W. Kan, Y. Chen, V. P. Wallace, Y. T. Zhang, and E. Pickwell-MacPherson, “Improved sample characterization in terahertz reflection imaging and spectroscopy,” Opt. Express 17(5), 3848–3854 (2009).
[Crossref] [PubMed]

Am. J. Phys. (1)

F. L. Curzon, “The Leidenfrost phenomenon,” Am. J. Phys. 46(8), 825 (1978).
[Crossref]

Appl. Phys. Lett. (1)

H. Hoshina, A. Hayashi, N. Miyoshi, F. Miyamaru, and C. Otani, “Terahertz pulsed imaging of frozen biological tissues,” Appl. Phys. Lett. 94(12), 123901 (2009).
[Crossref]

Appl. Spectrosc. (1)

Biomed. Opt. Express (1)

Br. J. Dermatol. (1)

V. P. Wallace, A. J. Fitzgerald, S. Shankar, N. Flanagan, R. Pye, J. Cluff, and D. D. Arnone, “Terahertz pulsed imaging of basal cell carcinoma ex vivo and in vivo,” Br. J. Dermatol. 151(2), 424–432 (2004).
[Crossref] [PubMed]

Caries Res. (1)

E. Pickwell, V. P. Wallace, B. E. Cole, S. Ali, C. Longbottom, R. J. Lynch, and M. Pepper, “A comparison of terahertz pulsed imaging with transmission microradiography for depth measurement of enamel demineralisation in vitro,” Caries Res. 41(1), 49–55 (2006).
[Crossref] [PubMed]

Cryobiology (1)

D. E. Pegg, “The relevance of ice crystal formation for the cryopreservation of tissues and organs,” Cryobiology 60(3Suppl), S36–S44 (2010).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

R. H. J. Daniel, M. Mittleman, and M. C. Nuss, “T-ray imaging,” IEEE J. Sel. Top. Quantum Electron. 2, 679–692 (1996).

J. Biomed. Opt. (2)

D. Crawley, C. Longbottom, V. P. Wallace, B. Cole, D. Arnone, and M. Pepper, “Three-dimensional terahertz pulse imaging of dental tissue,” J. Biomed. Opt. 8(2), 303–307 (2003).
[Crossref] [PubMed]

Y. Sun, B. M. Fischer, and E. Pickwell-MacPherson, “Effects of formalin fixing on the terahertz properties of biological tissues,” J. Biomed. Opt. 14(6), 064017 (2009).
[Crossref] [PubMed]

J. Food Eng. (1)

B. Li and D. W. Sun, “Effect of power ultrasound on freezing rate during immersion freezing of potatoes,” J. Food Eng. 55(3), 277–282 (2002).
[Crossref]

J. Invest. Dermatol. (1)

R. M. Woodward, V. P. Wallace, R. J. Pye, B. E. Cole, D. D. Arnone, E. H. Linfield, and M. Pepper, “Terahertz pulse imaging of ex vivo basal cell carcinoma,” J. Invest. Dermatol. 120(1), 72–78 (2003).
[Crossref] [PubMed]

J. Phys. D Appl. Phys. (1)

S. Fan, Y. He, B. S. Ung, and E. Pickwell-MacPherson, “The growth of biomedical terahertz research,” J. Phys. D Appl. Phys. 47(37), 374009 (2014).
[Crossref]

Opt. Express (1)

Photonics Research (1)

S. Fan, E. P. J. Parrott, B. S. Y. Ung, and E. Pickwell-MacPherson, “Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry,” Photonics Research 4(3), A29 (2016).
[Crossref]

Phys. Med. Biol. (3)

S. Sy, S. Huang, Y. X. Wang, J. Yu, A. T. Ahuja, Y. T. Zhang, and E. Pickwell-MacPherson, “Terahertz spectroscopy of liver cirrhosis: investigating the origin of contrast,” Phys. Med. Biol. 55(24), 7587–7596 (2010).
[Crossref] [PubMed]

S. Fan, B. Ung, E. P. Parrott, and E. Pickwell-MacPherson, “Gelatin embedding: a novel way to preserve biological samples for terahertz imaging and spectroscopy,” Phys. Med. Biol. 60(7), 2703–2713 (2015).
[Crossref] [PubMed]

G. M. Png, J. W. Choi, B. W. Ng, S. P. Mickan, D. Abbott, and X. C. Zhang, “The impact of hydration changes in fresh bio-tissue on THz spectroscopic measurements,” Phys. Med. Biol. 53(13), 3501–3517 (2008).
[Crossref] [PubMed]

Sci. Rep. (1)

E. Castro-Camus, M. Palomar, and A. A. Covarrubias, “Leaf water dynamics of Arabidopsis thaliana monitored in-vivo using terahertz time-domain spectroscopy,” Sci. Rep. 3, 2910 (2013).
[Crossref] [PubMed]

Trends Food Sci. Technol. (1)

H. Kiani and D.-W. Sun, “Water crystallization and its importance to freezing of foods: A review,” Trends Food Sci. Technol. 22(8), 407–426 (2011).
[Crossref]

Other (1)

MathWorks, “Detecting a Cell Using Image Segmentation” (2016), retrieved https://www.mathworks.com/help/images/examples/detecting-a-cell-using-image-segmentation.html .

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (5)

Fig. 1
Fig. 1 The average refractive index (a) and absorption coefficient (b) from slow-freeze, slow-thaw process.
Fig. 2
Fig. 2 (a) A photo of a fresh muscle sample. (b) The refractive index image of the muscle sample at 0.2 THz. The black dashed line is the sample outline and the white dashed line shows the useable area without edge effects. (c) The same muscle sample after slow-freezing and slow-thawing (d) A photo of a fresh fat sample. (e) The refractive index image of the fat sample at 0.2THz. The red dashed line indicates the useable area without edge effects (f) The same fat sample after slow-freezing and slow-thawing.
Fig. 3
Fig. 3 (a) The refractive index and (b) absorption coefficient of a muscle sample from a slow-freeze, slow-thaw cycle. (c) The absorption coefficient and refractive index between 0.2 and 0.8 THz. The hysteresis between the fresh, thawed and cold stages in the slow-freeze, slow-thaw process is clearly shown by the different curves for the fresh and thawed samples.
Fig. 4
Fig. 4 The average (a) refractive index and (b) absorption coefficient from snap-freeze, snap-thaw process.
Fig. 5
Fig. 5 The change of refractive index of the muscle tissue for four different freezing methods along with the cold sample.

Tables (1)

Tables Icon

Table 1 The weight loss (%) and the change of refractive index (Δn) at 0.4 THz

Metrics