Abstract

Determination of chemotherapy efficacy early during treatment would provide more opportunities for physicians to alter and adapt treatment plans. Diffuse optical technologies may be ideally suited to track early biological events following chemotherapy administration due to low cost and high information content. We evaluated the use of spatial frequency domain imaging (SFDI) to characterize a small animal tumor model in order to move towards the goal of endogenous optical monitoring of cancer therapy in a controlled preclinical setting. The effects of key measurement parameters including the choice of imaging spatial frequency and the repeatability of measurements were evaluated. The precision of SFDI optical property extractions over repeat mouse measurements was determined to be within 3.52% for move and replace experiments. Baseline optical properties and chromophore values as well as intratumor heterogeneity were evaluated over 25 tumors. Additionally, tumor growth and chemotherapy response were monitored over a 45 day longitudinal study in a small number of mice to demonstrate the ability of SFDI to track treatment effects. Optical scattering and oxygen saturation increased as much as 70% and 25% respectively in treated tumors, suggesting SFDI may be useful for preclinical tracking of cancer therapies.

© 2016 Optical Society of America

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2016 (2)

2015 (6)

K. P. Nadeau, T. B. Rice, A. J. Durkin, and B. J. Tromberg, “Multifrequency synthesis and extraction using square wave projection patterns for quantitative tissue imaging,” J. Biomed. Opt. 20(11), 116005 (2015).
[Crossref] [PubMed]

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Y. Zhao and D. Roblyer, “Spatial mapping of fluorophore quantum yield in diffusive media,” J. Biomed. Opt. 20(8), 086013 (2015).
[Crossref] [PubMed]

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

X. X. Sun and Q. Yu, “Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment,” Acta Pharmacol. Sin. 36(10), 1219–1227 (2015).
[Crossref] [PubMed]

2014 (3)

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

R. P. Singh-Moon, D. M. Roblyer, I. J. Bigio, and S. Joshi, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,” J. Biomed. Opt. 19(9), 096003 (2014).
[Crossref] [PubMed]

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

2013 (8)

U. Sunar, D. J. Rohrbach, J. Morgan, N. Zeitouni, and B. W. Henderson, “Quantification of PpIX concentration in basal cell carcinoma and squamous cell carcinoma models using spatial frequency domain imaging,” Biomed. Opt. Express 4(4), 531–537 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

K. Zhang and D. J. Waxman, “Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model,” Mol. Cancer Ther. 12(5), 787–798 (2013).
[Crossref] [PubMed]

C. Holohan, S. Van Schaeybroeck, D. B. Longley, and P. G. Johnston, “Cancer drug resistance: an evolving paradigm,” Nat. Rev. Cancer 13(10), 714–726 (2013).
[Crossref] [PubMed]

K. P. Nadeau, A. Ponticorvo, H. J. Lee, D. Lu, A. J. Durkin, and B. J. Tromberg, “Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging,” Opt. Lett. 38(18), 3566–3569 (2013).
[Crossref] [PubMed]

A. Ponticorvo, E. Taydas, A. Mazhar, T. Scholz, H. S. Kim, J. Rimler, G. R. Evans, D. J. Cuccia, and A. J. Durkin, “Quantitative assessment of partial vascular occlusions in a swine pedicle flap model using spatial frequency domain imaging,” Biomed. Opt. Express 4(2), 298–306 (2013).
[Crossref] [PubMed]

C. E. Meacham and S. J. Morrison, “Tumour heterogeneity and cancer cell plasticity,” Nature 501(7467), 328–337 (2013).
[Crossref] [PubMed]

2012 (6)

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

2011 (8)

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

M. Martinelli, A. Gardner, D. Cuccia, C. Hayakawa, J. Spanier, and V. Venugopalan, “Analysis of single Monte Carlo methods for prediction of reflectance from turbid media,” Opt. Express 19(20), 19627–19642 (2011).
[Crossref] [PubMed]

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

T. L. Becker, A. D. Paquette, K. R. Keymel, B. W. Henderson, and U. Sunar, “Monitoring blood flow responses during topical ALA-PDT,” Biomed. Opt. Express 2(1), 123–130 (2011).
[Crossref] [PubMed]

2010 (4)

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

J. Condeelis and R. Weissleder, “In vivo Imaging in Cancer,” Cold Spring Harb. Perspect. Biol. 2(12), a003848 (2010).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

2009 (5)

F. S. Liu, “Mechanisms of chemotherapeutic drug resistance in cancer therapy--a quick review,” Taiwan. J. Obstet. Gynecol. 48(3), 239–244 (2009).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

K. Vishwanath, H. Yuan, W. T. Barry, M. W. Dewhirst, and N. Ramanujam, “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors,” Neoplasia 11(9), 889–900 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

2008 (1)

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

2007 (2)

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

2005 (2)

2004 (1)

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

2001 (1)

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

1997 (1)

W. G. Zijlstra and A. Buursma, “Spectrophotometry of hemoglobin: Absorption spectra of bovine oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Comp. Biochem. Physiol. B Biochem. Mol. Biol. 118(4), 743–749 (1997).
[Crossref]

Ashitate, Y.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Ayers, F. R.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

Baker, W. B.

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Barry, W. T.

K. Vishwanath, H. Yuan, W. T. Barry, M. W. Dewhirst, and N. Ramanujam, “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors,” Neoplasia 11(9), 889–900 (2009).
[Crossref] [PubMed]

Barth, R. J.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

Becker, T. L.

Bernal, N.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Berrington de Gonzalez, A.

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

Bevilacqua, F.

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Bigio, I. J.

R. P. Singh-Moon, D. M. Roblyer, I. J. Bigio, and S. Joshi, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,” J. Biomed. Opt. 19(9), 096003 (2014).
[Crossref] [PubMed]

Borden, M. A.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Bray, F.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Busch, D. R.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Busch, T. M.

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Butler, J.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Butler, J. A.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Buursma, A.

W. G. Zijlstra and A. Buursma, “Spectrophotometry of hemoglobin: Absorption spectra of bovine oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Comp. Biochem. Physiol. B Biochem. Mol. Biol. 118(4), 743–749 (1997).
[Crossref]

Cerussi, A.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Cerussi, A. E.

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

Chan, A.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Charehbili, A.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Chen, W. P.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Choe, R.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Choi, B.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Chung, S. H.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Condeelis, J.

J. Condeelis and R. Weissleder, “In vivo Imaging in Cancer,” Cold Spring Harb. Perspect. Biol. 2(12), a003848 (2010).
[Crossref] [PubMed]

Cook, A. M.

A. M. Cook, W. J. Lesterhuis, A. K. Nowak, and R. A. Lake, “Chemotherapy and immunotherapy: mapping the road ahead,” Curr. Opin. Immunol. 39, 23–29 (2016).
[Crossref] [PubMed]

Crouzet, C.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Cuccia, D.

Cuccia, D. J.

A. Ponticorvo, E. Taydas, A. Mazhar, T. Scholz, H. S. Kim, J. Rimler, G. R. Evans, D. J. Cuccia, and A. J. Durkin, “Quantitative assessment of partial vascular occlusions in a swine pedicle flap model using spatial frequency domain imaging,” Biomed. Opt. Express 4(2), 298–306 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Czarnota, G. J.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Czerniecki, B. J.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Dell, S.

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

DeMichele, A.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Dent, R.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Dewhirst, M. W.

K. Vishwanath, H. Yuan, W. T. Barry, M. W. Dewhirst, and N. Ramanujam, “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors,” Neoplasia 11(9), 889–900 (2009).
[Crossref] [PubMed]

DiFlorio-Alexander, R.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

Dijkstra, J.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Dikshit, R.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Durduran, T.

Durkin, A.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Durkin, A. J.

K. P. Nadeau, T. B. Rice, A. J. Durkin, and B. J. Tromberg, “Multifrequency synthesis and extraction using square wave projection patterns for quantitative tissue imaging,” J. Biomed. Opt. 20(11), 116005 (2015).
[Crossref] [PubMed]

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

A. Ponticorvo, E. Taydas, A. Mazhar, T. Scholz, H. S. Kim, J. Rimler, G. R. Evans, D. J. Cuccia, and A. J. Durkin, “Quantitative assessment of partial vascular occlusions in a swine pedicle flap model using spatial frequency domain imaging,” Biomed. Opt. Express 4(2), 298–306 (2013).
[Crossref] [PubMed]

K. P. Nadeau, A. Ponticorvo, H. J. Lee, D. Lu, A. J. Durkin, and B. J. Tromberg, “Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging,” Opt. Lett. 38(18), 3566–3569 (2013).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Durr, N. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Emanuele, M. J.

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Eser, S.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Evans, G. R.

A. Ponticorvo, E. Taydas, A. Mazhar, T. Scholz, H. S. Kim, J. Rimler, G. R. Evans, D. J. Cuccia, and A. J. Durkin, “Quantitative assessment of partial vascular occlusions in a swine pedicle flap model using spatial frequency domain imaging,” Biomed. Opt. Express 4(2), 298–306 (2013).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Feldman, M. D.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Ferlay, J.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Flexman, M. L.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Forman, D.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Frangioni, J. V.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

Frazee, T. E.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

Froehlich, H. M.

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Gander, J. W.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Gardner, A.

Gioux, S.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

Glatstein, E.

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Gomez-Abuin, G.

S. D. Undevia, G. Gomez-Abuin, and M. J. Ratain, “Pharmacokinetic variability of anticancer agents,” Nat. Rev. Cancer 5(6), 447–458 (2005).
[Crossref] [PubMed]

Green, K. N.

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

Gui, J.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

Gunasekara, A.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Hayakawa, C.

Hegde, P.

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

Henderson, B. W.

Hernandez, S. L.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Hielscher, A. H.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Holohan, C.

C. Holohan, S. Van Schaeybroeck, D. B. Longley, and P. G. Johnston, “Cancer drug resistance: an evolving paradigm,” Nat. Rev. Cancer 13(10), 714–726 (2013).
[Crossref] [PubMed]

Hsiang, D.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Huang, J.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Huihui, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Jermyn, M.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

Jiang, S.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Johnston, P. G.

C. Holohan, S. Van Schaeybroeck, D. B. Longley, and P. G. Johnston, “Cancer drug resistance: an evolving paradigm,” Nat. Rev. Cancer 13(10), 714–726 (2013).
[Crossref] [PubMed]

Johung, T. B.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Joshi, S.

R. P. Singh-Moon, D. M. Roblyer, I. J. Bigio, and S. Joshi, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,” J. Biomed. Opt. 19(9), 096003 (2014).
[Crossref] [PubMed]

Kandel, J. J.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Kane, M.

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

Kaufman, P. A.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Kelly, E.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Kelly, K. M.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Keymel, K.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Keymel, K. R.

Kim, H.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Kim, H. K.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Kim, H. S.

Kim, J. G.

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

Kleinerman, R.

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

Koike, M. A.

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

Kolste, K.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Konecky, S. D.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

Krishnaswamy, V.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

Kroep, J. R.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Kurtzman, S. H.

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

LaFerla, F. M.

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

Lake, R. A.

A. M. Cook, W. J. Lesterhuis, A. K. Nowak, and R. A. Lake, “Chemotherapy and immunotherapy: mapping the road ahead,” Curr. Opin. Immunol. 39, 23–29 (2016).
[Crossref] [PubMed]

Lampl, B. S.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Laughney, A. M.

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

Leblond, F.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Lee, B. T.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Lee, C.

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

Lee, H. J.

Lee, W. M.

Lelieveldt, B. P.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Leproux, A.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

Lesterhuis, W. J.

A. M. Cook, W. J. Lesterhuis, A. K. Nowak, and R. A. Lake, “Chemotherapy and immunotherapy: mapping the road ahead,” Curr. Opin. Immunol. 39, 23–29 (2016).
[Crossref] [PubMed]

Li, Z.

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Liaw, L. H.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Liefers, G. J.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Lin, A. J.

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

Lin, S. J.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Linet, M. S.

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

Liu, F. S.

F. S. Liu, “Mechanisms of chemotherapeutic drug resistance in cancer therapy--a quick review,” Taiwan. J. Obstet. Gynecol. 48(3), 239–244 (2009).
[Crossref] [PubMed]

Longley, D. B.

C. Holohan, S. Van Schaeybroeck, D. B. Longley, and P. G. Johnston, “Cancer drug resistance: an evolving paradigm,” Nat. Rev. Cancer 13(10), 714–726 (2013).
[Crossref] [PubMed]

Löwik, C. W.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Lu, D.

Mai, T.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Makonnen, S.

Martinelli, M.

Martinez, D.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Mathers, C.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Mazhar, A.

A. Ponticorvo, E. Taydas, A. Mazhar, T. Scholz, H. S. Kim, J. Rimler, G. R. Evans, D. J. Cuccia, and A. J. Durkin, “Quantitative assessment of partial vascular occlusions in a swine pedicle flap model using spatial frequency domain imaging,” Biomed. Opt. Express 4(2), 298–306 (2013).
[Crossref] [PubMed]

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

McBride, T. O.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

McLaren, C.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Meacham, C. E.

C. E. Meacham and S. J. Morrison, “Tumour heterogeneity and cancer cell plasticity,” Nature 501(7467), 328–337 (2013).
[Crossref] [PubMed]

Mehta, R.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Miller, D. L.

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

Moffitt, L. A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Morgan, J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

U. Sunar, D. J. Rohrbach, J. Morgan, N. Zeitouni, and B. W. Henderson, “Quantification of PpIX concentration in basal cell carcinoma and squamous cell carcinoma models using spatial frequency domain imaging,” Biomed. Opt. Express 4(4), 531–537 (2013).
[Crossref] [PubMed]

Morrison, S. J.

C. E. Meacham and S. J. Morrison, “Tumour heterogeneity and cancer cell plasticity,” Nature 501(7467), 328–337 (2013).
[Crossref] [PubMed]

Muffoletto, D.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Nadeau, K. P.

K. P. Nadeau, T. B. Rice, A. J. Durkin, and B. J. Tromberg, “Multifrequency synthesis and extraction using square wave projection patterns for quantitative tissue imaging,” J. Biomed. Opt. 20(11), 116005 (2015).
[Crossref] [PubMed]

K. P. Nadeau, A. Ponticorvo, H. J. Lee, D. Lu, A. J. Durkin, and B. J. Tromberg, “Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging,” Opt. Lett. 38(18), 3566–3569 (2013).
[Crossref] [PubMed]

Nandhu, M. S.

Nguyen, J. Q.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Nowak, A. K.

A. M. Cook, W. J. Lesterhuis, A. K. Nowak, and R. A. Lake, “Chemotherapy and immunotherapy: mapping the road ahead,” Curr. Opin. Immunol. 39, 23–29 (2016).
[Crossref] [PubMed]

O’Sullivan, T. D.

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

Oketokoun, R.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Osterberg, U. L.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

Osterman, K. S.

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

Owen, C. M.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Pakalniskis, M. G.

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Paquette, A.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Paquette, A. D.

Parkin, D. M.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Patel, S.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Paulsen, K. D.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

Piracha, S.

Pogue, B. W.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

Ponticorvo, A.

Poplack, S. P.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

Putt, M. E.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Rajaraman, P.

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

Ramanujam, N.

K. Vishwanath, H. Yuan, W. T. Barry, M. W. Dewhirst, and N. Ramanujam, “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors,” Neoplasia 11(9), 889–900 (2009).
[Crossref] [PubMed]

Ratain, M. J.

S. D. Undevia, G. Gomez-Abuin, and M. J. Ratain, “Pharmacokinetic variability of anticancer agents,” Nat. Rev. Cancer 5(6), 447–458 (2005).
[Crossref] [PubMed]

Rebelo, M.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Reichstein, A. R.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Rice, T.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Rice, T. B.

K. P. Nadeau, T. B. Rice, A. J. Durkin, and B. J. Tromberg, “Multifrequency synthesis and extraction using square wave projection patterns for quantitative tissue imaging,” J. Biomed. Opt. 20(11), 116005 (2015).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

Rimler, J.

Riola, K.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Rizzo, E. J.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

Roberts, D. W.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Roblyer, D.

Y. Zhao, S. Tabassum, S. Piracha, M. S. Nandhu, M. Viapiano, and D. Roblyer, “Angle correction for small animal tumor imaging with spatial frequency domain imaging (SFDI),” Biomed. Opt. Express 7(6), 2373–2384 (2016).
[Crossref] [PubMed]

Y. Zhao and D. Roblyer, “Spatial mapping of fluorophore quantum yield in diffusive media,” J. Biomed. Opt. 20(8), 086013 (2015).
[Crossref] [PubMed]

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Roblyer, D. M.

R. P. Singh-Moon, D. M. Roblyer, I. J. Bigio, and S. Joshi, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,” J. Biomed. Opt. 19(9), 096003 (2014).
[Crossref] [PubMed]

Rohrbach, D. J.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

U. Sunar, D. J. Rohrbach, J. Morgan, N. Zeitouni, and B. W. Henderson, “Quantification of PpIX concentration in basal cell carcinoma and squamous cell carcinoma models using spatial frequency domain imaging,” Biomed. Opt. Express 4(4), 531–537 (2013).
[Crossref] [PubMed]

Rosen, M. A.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Rycroft, M.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Saager, R.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Saager, R. B.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Saggese, S.

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

Santoro, Y.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

Schaafsma, B. E.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Schnall, M. D.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Scholz, T.

A. Ponticorvo, E. Taydas, A. Mazhar, T. Scholz, H. S. Kim, J. Rimler, G. R. Evans, D. J. Cuccia, and A. J. Durkin, “Quantitative assessment of partial vascular occlusions in a swine pedicle flap model using spatial frequency domain imaging,” Biomed. Opt. Express 4(2), 298–306 (2013).
[Crossref] [PubMed]

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Schotland, J. C.

Schwab, M. C.

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Shah, N.

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Shin, D. B.

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Singh-Moon, R. P.

R. P. Singh-Moon, D. M. Roblyer, I. J. Bigio, and S. Joshi, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,” J. Biomed. Opt. 19(9), 096003 (2014).
[Crossref] [PubMed]

Sirsi, S. R.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Slovis, T. L.

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

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B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Soerjomataram, I.

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

Soliman, H.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Spanier, J.

Spayne, J.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Stockdale, A.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

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X. X. Sun and Q. Yu, “Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment,” Acta Pharmacol. Sin. 36(10), 1219–1227 (2015).
[Crossref] [PubMed]

Sunar, U.

Tabassum, S.

Tanamai, W.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Tannenbaum, S.

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

Taydas, E.

Tchou, J.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

Tobias, A. M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Tosteson, T. D.

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Tromberg, B.

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

Tromberg, B. J.

K. P. Nadeau, T. B. Rice, A. J. Durkin, and B. J. Tromberg, “Multifrequency synthesis and extraction using square wave projection patterns for quantitative tissue imaging,” J. Biomed. Opt. 20(11), 116005 (2015).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

K. P. Nadeau, A. Ponticorvo, H. J. Lee, D. Lu, A. J. Durkin, and B. J. Tromberg, “Quantitative assessment of renal arterial occlusion in a porcine model using spatial frequency domain imaging,” Opt. Lett. 38(18), 3566–3569 (2013).
[Crossref] [PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

S. D. Konecky, A. Mazhar, D. Cuccia, A. J. Durkin, J. C. Schotland, and B. J. Tromberg, “Quantitative optical tomography of sub-surface heterogeneities using spatially modulated structured light,” Opt. Express 17(17), 14780–14790 (2009).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, and B. J. Tromberg, “Modulated imaging: quantitative analysis and tomography of turbid media in the spatial-frequency domain,” Opt. Lett. 30(11), 1354–1356 (2005).
[Crossref] [PubMed]

Uchitel, D.

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

Ueda, S.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

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S. D. Undevia, G. Gomez-Abuin, and M. J. Ratain, “Pharmacokinetic variability of anticancer agents,” Nat. Rev. Cancer 5(6), 447–458 (2005).
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B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Valdés, P. A.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

van de Giessen, M.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

van de Velde, C. J.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

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C. Holohan, S. Van Schaeybroeck, D. B. Longley, and P. G. Johnston, “Cancer drug resistance: an evolving paradigm,” Nat. Rev. Cancer 13(10), 714–726 (2013).
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Venugopalan, V.

Vetter, T. S.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Viapiano, M.

Vishwanath, K.

K. Vishwanath, H. Yuan, W. T. Barry, M. W. Dewhirst, and N. Ramanujam, “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors,” Neoplasia 11(9), 889–900 (2009).
[Crossref] [PubMed]

Vlachos, F.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Wang, A.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Wang, H. W.

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Wasser, M. N.

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

Waxman, D. J.

K. Zhang and D. J. Waxman, “Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model,” Mol. Cancer Ther. 12(5), 787–798 (2013).
[Crossref] [PubMed]

Weinmann, M.

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

Weissleder, R.

J. Condeelis and R. Weissleder, “In vivo Imaging in Cancer,” Cold Spring Harb. Perspect. Biol. 2(12), a003848 (2010).
[Crossref] [PubMed]

Wells, W. A.

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

Wilson, B. C.

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

Xu, C.

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

Xu, S.

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

Yaffe, M. J.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Yafi, A.

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Yamashiro, D. J.

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Yodh, A. G.

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

U. Sunar, S. Makonnen, C. Zhou, T. Durduran, G. Yu, H. W. Wang, W. M. Lee, and A. G. Yodh, “Hemodynamic responses to antivascular therapy and ionizing radiation assessed by diffuse optical spectroscopies,” Opt. Express 15(23), 15507–15516 (2007).
[Crossref] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Yu, G.

Yu, Q.

X. X. Sun and Q. Yu, “Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment,” Acta Pharmacol. Sin. 36(10), 1219–1227 (2015).
[Crossref] [PubMed]

Yuan, H.

K. Vishwanath, H. Yuan, W. T. Barry, M. W. Dewhirst, and N. Ramanujam, “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors,” Neoplasia 11(9), 889–900 (2009).
[Crossref] [PubMed]

Zeitouni, N.

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

U. Sunar, D. J. Rohrbach, J. Morgan, N. Zeitouni, and B. W. Henderson, “Quantification of PpIX concentration in basal cell carcinoma and squamous cell carcinoma models using spatial frequency domain imaging,” Biomed. Opt. Express 4(4), 531–537 (2013).
[Crossref] [PubMed]

Zhang, K.

K. Zhang and D. J. Waxman, “Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model,” Mol. Cancer Ther. 12(5), 787–798 (2013).
[Crossref] [PubMed]

Zhao, Y.

Zhou, C.

Zhu, Q.

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

Zijlstra, W. G.

W. G. Zijlstra and A. Buursma, “Spectrophotometry of hemoglobin: Absorption spectra of bovine oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Comp. Biochem. Physiol. B Biochem. Mol. Biol. 118(4), 743–749 (1997).
[Crossref]

Zubovits, J.

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

Acad. Radiol. (1)

D. J. Rohrbach, D. Muffoletto, J. Huihui, R. Saager, K. Keymel, A. Paquette, J. Morgan, N. Zeitouni, and U. Sunar, “Preoperative mapping of nonmelanoma skin cancer using spatial frequency domain and ultrasound imaging,” Acad. Radiol. 21(2), 263–270 (2014).
[Crossref] [PubMed]

Acta Pharmacol. Sin. (1)

X. X. Sun and Q. Yu, “Intra-tumor heterogeneity of cancer cells and its implications for cancer treatment,” Acta Pharmacol. Sin. 36(10), 1219–1227 (2015).
[Crossref] [PubMed]

Ann. Biomed. Eng. (1)

A. J. Lin, M. A. Koike, K. N. Green, J. G. Kim, A. Mazhar, T. B. Rice, F. M. LaFerla, and B. J. Tromberg, “Spatial frequency domain imaging of intrinsic optical property contrast in a mouse model of Alzheimer’s disease,” Ann. Biomed. Eng. 39(4), 1349–1357 (2011).
[Crossref] [PubMed]

Biomed. Opt. Express (4)

Breast Cancer Res. (1)

S. H. Chung, M. D. Feldman, D. Martinez, H. Kim, M. E. Putt, D. R. Busch, J. Tchou, B. J. Czerniecki, M. D. Schnall, M. A. Rosen, A. DeMichele, A. G. Yodh, and R. Choe, “Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures,” Breast Cancer Res. 17(1), 72 (2015).
[Crossref] [PubMed]

CA Cancer J. Clin. (1)

M. S. Linet, T. L. Slovis, D. L. Miller, R. Kleinerman, C. Lee, P. Rajaraman, and A. Berrington de Gonzalez, “Cancer risks associated with external radiation from diagnostic imaging procedures,” CA Cancer J. Clin. 62(2), 75–100 (2012).
[Crossref] [PubMed]

Cancer Res. (2)

S. Ueda, D. Roblyer, A. Cerussi, A. Durkin, A. Leproux, Y. Santoro, S. Xu, T. D. O’Sullivan, D. Hsiang, R. Mehta, J. Butler, and B. J. Tromberg, “Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy,” Cancer Res. 72(17), 4318–4328 (2012).
[Crossref] [PubMed]

H. W. Wang, M. E. Putt, M. J. Emanuele, D. B. Shin, E. Glatstein, A. G. Yodh, and T. M. Busch, “Treatment-induced changes in tumor oxygenation predict photodynamic therapy outcome,” Cancer Res. 64(20), 7553–7561 (2004).
[Crossref] [PubMed]

Clin. Cancer Res. (4)

B. E. Schaafsma, M. van de Giessen, A. Charehbili, V. T. Smit, J. R. Kroep, B. P. Lelieveldt, G. J. Liefers, A. Chan, C. W. Löwik, J. Dijkstra, C. J. van de Velde, M. N. Wasser, and A. L. Vahrmeijer, “Optical mammography using diffuse optical spectroscopy for monitoring tumor response to neoadjuvant chemotherapy in women with locally advanced breast cancer,” Clin. Cancer Res. 21(3), 577–584 (2015).
[Crossref] [PubMed]

S. Jiang, B. W. Pogue, P. A. Kaufman, J. Gui, M. Jermyn, T. E. Frazee, S. P. Poplack, R. DiFlorio-Alexander, W. A. Wells, and K. D. Paulsen, “Predicting breast tumor response to neoadjuvant chemotherapy with diffuse optical spectroscopic tomography prior to treatment,” Clin. Cancer Res. 20(23), 6006–6015 (2014).
[Crossref] [PubMed]

H. Soliman, A. Gunasekara, M. Rycroft, J. Zubovits, R. Dent, J. Spayne, M. J. Yaffe, and G. J. Czarnota, “Functional imaging using diffuse optical spectroscopy of neoadjuvant chemotherapy response in women with locally advanced breast cancer,” Clin. Cancer Res. 16(9), 2605–2614 (2010).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, E. J. Rizzo, M. C. Schwab, R. J. Barth, B. W. Pogue, K. D. Paulsen, and W. A. Wells, “Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment,” Clin. Cancer Res. 18(22), 6315–6325 (2012).
[Crossref] [PubMed]

Cold Spring Harb. Perspect. Biol. (1)

J. Condeelis and R. Weissleder, “In vivo Imaging in Cancer,” Cold Spring Harb. Perspect. Biol. 2(12), a003848 (2010).
[Crossref] [PubMed]

Comp. Biochem. Physiol. B Biochem. Mol. Biol. (1)

W. G. Zijlstra and A. Buursma, “Spectrophotometry of hemoglobin: Absorption spectra of bovine oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin, and methemoglobin,” Comp. Biochem. Physiol. B Biochem. Mol. Biol. 118(4), 743–749 (1997).
[Crossref]

Curr. Opin. Immunol. (1)

A. M. Cook, W. J. Lesterhuis, A. K. Nowak, and R. A. Lake, “Chemotherapy and immunotherapy: mapping the road ahead,” Curr. Opin. Immunol. 39, 23–29 (2016).
[Crossref] [PubMed]

Int. J. Cancer (1)

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012,” Int. J. Cancer 136(5), E359–E386 (2015).
[Crossref] [PubMed]

J. Biomed. Opt. (13)

T. D. O’Sullivan, A. E. Cerussi, D. J. Cuccia, and B. J. Tromberg, “Diffuse optical imaging using spatially and temporally modulated light,” J. Biomed. Opt. 17(7), 071311 (2012).
[PubMed]

S. D. Konecky, C. M. Owen, T. Rice, P. A. Valdés, K. Kolste, B. C. Wilson, F. Leblond, D. W. Roberts, K. D. Paulsen, and B. J. Tromberg, “Spatial frequency domain tomography of protoporphyrin IX fluorescence in preclinical glioma models,” J. Biomed. Opt. 17(5), 056008 (2012).
[Crossref] [PubMed]

R. B. Saager, D. J. Cuccia, S. Saggese, K. M. Kelly, and A. J. Durkin, “Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain,” J. Biomed. Opt. 16(12), 126013 (2011).
[Crossref] [PubMed]

A. M. Laughney, V. Krishnaswamy, T. B. Rice, D. J. Cuccia, R. J. Barth, B. J. Tromberg, K. D. Paulsen, B. W. Pogue, and W. A. Wells, “System analysis of spatial frequency domain imaging for quantitative mapping of surgically resected breast tissues,” J. Biomed. Opt. 18(3), 036012 (2013).
[Crossref] [PubMed]

D. J. Cuccia, F. Bevilacqua, A. J. Durkin, F. R. Ayers, and B. J. Tromberg, “Quantitation and mapping of tissue optical properties using modulated imaging,” J. Biomed. Opt. 14(2), 024012 (2009).
[Crossref] [PubMed]

K. P. Nadeau, T. B. Rice, A. J. Durkin, and B. J. Tromberg, “Multifrequency synthesis and extraction using square wave projection patterns for quantitative tissue imaging,” J. Biomed. Opt. 20(11), 116005 (2015).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, D. J. Cuccia, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “Three-dimensional surface profile intensity correction for spatially modulated imaging,” J. Biomed. Opt. 14(3), 034045 (2009).
[Crossref] [PubMed]

R. P. Singh-Moon, D. M. Roblyer, I. J. Bigio, and S. Joshi, “Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging,” J. Biomed. Opt. 19(9), 096003 (2014).
[Crossref] [PubMed]

Y. Zhao and D. Roblyer, “Spatial mapping of fluorophore quantum yield in diffusive media,” J. Biomed. Opt. 20(8), 086013 (2015).
[Crossref] [PubMed]

S. Gioux, A. Mazhar, B. T. Lee, S. J. Lin, A. M. Tobias, D. J. Cuccia, A. Stockdale, R. Oketokoun, Y. Ashitate, E. Kelly, M. Weinmann, N. J. Durr, L. A. Moffitt, A. J. Durkin, B. J. Tromberg, and J. V. Frangioni, “First-in-human pilot study of a spatial frequency domain oxygenation imaging system,” J. Biomed. Opt. 16(8), 086015 (2011).
[Crossref] [PubMed]

J. Q. Nguyen, C. Crouzet, T. Mai, K. Riola, D. Uchitel, L. H. Liaw, N. Bernal, A. Ponticorvo, B. Choi, and A. J. Durkin, “Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity,” J. Biomed. Opt. 18(6), 066010 (2013).
[Crossref] [PubMed]

A. Mazhar, S. Dell, D. J. Cuccia, S. Gioux, A. J. Durkin, J. V. Frangioni, and B. J. Tromberg, “Wavelength optimization for rapid chromophore mapping using spatial frequency domain imaging,” J. Biomed. Opt. 15(6), 061716 (2010).
[Crossref] [PubMed]

M. L. Flexman, F. Vlachos, H. K. Kim, S. R. Sirsi, J. Huang, S. L. Hernandez, T. B. Johung, J. W. Gander, A. R. Reichstein, B. S. Lampl, A. Wang, M. A. Borden, D. J. Yamashiro, J. J. Kandel, and A. H. Hielscher, “Monitoring early tumor response to drug therapy with diffuse optical tomography,” J. Biomed. Opt. 17(1), 016014 (2012).
[Crossref] [PubMed]

Mol. Cancer Ther. (1)

K. Zhang and D. J. Waxman, “Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model,” Mol. Cancer Ther. 12(5), 787–798 (2013).
[Crossref] [PubMed]

Nat. Rev. Cancer (2)

C. Holohan, S. Van Schaeybroeck, D. B. Longley, and P. G. Johnston, “Cancer drug resistance: an evolving paradigm,” Nat. Rev. Cancer 13(10), 714–726 (2013).
[Crossref] [PubMed]

S. D. Undevia, G. Gomez-Abuin, and M. J. Ratain, “Pharmacokinetic variability of anticancer agents,” Nat. Rev. Cancer 5(6), 447–458 (2005).
[Crossref] [PubMed]

Nature (1)

C. E. Meacham and S. J. Morrison, “Tumour heterogeneity and cancer cell plasticity,” Nature 501(7467), 328–337 (2013).
[Crossref] [PubMed]

Neoplasia (2)

K. Vishwanath, H. Yuan, W. T. Barry, M. W. Dewhirst, and N. Ramanujam, “Using optical spectroscopy to longitudinally monitor physiological changes within solid tumors,” Neoplasia 11(9), 889–900 (2009).
[Crossref] [PubMed]

Q. Zhu, S. Tannenbaum, P. Hegde, M. Kane, C. Xu, and S. H. Kurtzman, “Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization,” Neoplasia 10(10), 1028–1040 (2008).
[Crossref] [PubMed]

Opt. Express (3)

Opt. Lett. (2)

Plast. Reconstr. Surg. (1)

A. Yafi, T. S. Vetter, T. Scholz, S. Patel, R. B. Saager, D. J. Cuccia, G. R. Evans, and A. J. Durkin, “Postoperative quantitative assessment of reconstructive tissue status in a cutaneous flap model using spatial frequency domain imaging,” Plast. Reconstr. Surg. 127(1), 117–130 (2011).
[Crossref] [PubMed]

Proc. Natl. Acad. Sci. U.S.A. (2)

D. Roblyer, S. Ueda, A. Cerussi, W. Tanamai, A. Durkin, R. Mehta, D. Hsiang, J. A. Butler, C. McLaren, W. P. Chen, and B. Tromberg, “Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment,” Proc. Natl. Acad. Sci. U.S.A. 108(35), 14626–14631 (2011).
[Crossref] [PubMed]

A. Cerussi, D. Hsiang, N. Shah, R. Mehta, A. Durkin, J. Butler, and B. J. Tromberg, “Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy,” Proc. Natl. Acad. Sci. U.S.A. 104(10), 4014–4019 (2007).
[Crossref] [PubMed]

Radiology (2)

B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, “Quantitative hemoglobin tomography with diffuse near-infrared spectroscopy: pilot results in the breast,” Radiology 218(1), 261–266 (2001).
[Crossref] [PubMed]

M. G. Pakalniskis, W. A. Wells, M. C. Schwab, H. M. Froehlich, S. Jiang, Z. Li, T. D. Tosteson, S. P. Poplack, P. A. Kaufman, B. W. Pogue, and K. D. Paulsen, “Tumor angiogenesis change estimated by using diffuse optical spectroscopic tomography: demonstrated correlation in women undergoing neoadjuvant chemotherapy for invasive breast cancer?” Radiology 259(2), 365–374 (2011).
[Crossref] [PubMed]

Rep. Prog. Phys. (1)

T. Durduran, R. Choe, W. B. Baker, and A. G. Yodh, “Diffuse Optics for Tissue Monitoring and Tomography,” Rep. Prog. Phys. 73(7), 076701 (2010).
[Crossref] [PubMed]

Taiwan. J. Obstet. Gynecol. (1)

F. S. Liu, “Mechanisms of chemotherapeutic drug resistance in cancer therapy--a quick review,” Taiwan. J. Obstet. Gynecol. 48(3), 239–244 (2009).
[Crossref] [PubMed]

Other (1)

A. C. Society, Cancer Facts and Figs. 2016. 2016.

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Figures (6)

Fig. 1
Fig. 1 SFDI setup for mouse imaging (left), schematic (middle) and setup (right) of tilt measurements.
Fig. 2
Fig. 2 Two-fx-LUT’s using 10 evenly distributed μa values (0.003 – 0.055 mm−1) and 10 evenly distributed μs` values (0.5 - 3 mm−1) for DC and 0.025 mm−1 (top left), DC and 0.1 mm−1 (top right), DC and 0.2 mm−1 (bottom left), DC and 0.5 mm−1 (bottom right) fx pairs.
Fig. 3
Fig. 3 Extraction error of μa (top) and μs` (bottom), where low μa = 0.005 mm−1, low μs` = 0.73 mm−1, high μa = 0.035 mm−1, and high μs` = 1.89 mm−1.
Fig. 4
Fig. 4 Locations of pixels on a DC101-treated tumor at pretreatment (top left) and posttreatment (bottom left) timepoints. Broadband fitting of absorption (top right) and scattering (bottom right) for pre- and posttreatment timepoints.
Fig. 5
Fig. 5 Absorption (left axis) and scattering (right axis) at 851 nm for a representative tumor over 10 stationary (top left), 10 move & replace (top right), and 11 tilt (bottom) repeat measurements.
Fig. 6
Fig. 6 μs` (left axis) and tumor volume (right axis) over days of DC101 treated tumor (top left), μs` colormaps overlaid on the DC101 treated planar mouse image at day 0 and day 24 (top right), StO2 (left axis) and tumor volume (right axis) over days for CPA treated tumor (bottom left), StO2 colormaps overlaid on the CPA treated planar mouse image at day 0 and day 24 (bottom right).

Tables (3)

Tables Icon

Table 1 Average SFDI parameters for tumors

Tables Icon

Table 2 Intratumor heterogeneity

Tables Icon

Table 3 Repeatability (Precision)

Equations (4)

Equations on this page are rendered with MathJax. Learn more.

R d_sample ( f x )= M ac_sample ( f x ) M ac_phantom ( f x ) R d_phantom ( f x )
μ a (λ)= ε Hb O 2 (λ) C Hb O 2 + ε Hb (λ) C Hb
μ s `(λ)=a ( λ λ o ) b .
R d_fine_tuned (x,y,wv, f x )= R d (x,y,wv, f x ) R d_gold_standard (wv, f x ) R d (wv, f x ) ROI .

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