Abstract

Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a wide-aperture annular actuator with an internal diameter of 65 mm. We demonstrate feasibility by presenting elastograms recorded from freshly excised human breast tissue, including from a mastectomy, lumpectomies and a cavity shaving.

© 2016 Optical Society of America

Full Article  |  PDF Article
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References

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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  26. K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
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    [Crossref] [PubMed]
  29. L. Chin, A. Curatolo, B. F. Kennedy, B. J. Doyle, P. R. T. Munro, R. A. McLaughlin, and D. D. Sampson, “Analysis of image formation in optical coherence elastography using a multiphysics approach,” Biomed. Opt. Express 5(9), 2913–2930 (2014).
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
  32. M. Singh, C. Wu, C.-H. Liu, J. Li, A. Schill, A. Nair, and K. V. Larin, “Phase-sensitive optical coherence elastography at 1.5 million A-Lines per second,” Opt. Lett. 40(11), 2588–2591 (2015).
    [Crossref] [PubMed]
  33. B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref]
  36. A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
    [Crossref] [PubMed]
  37. T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
    [Crossref] [PubMed]
  38. K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
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    [Crossref] [PubMed]

2016 (1)

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

2015 (7)

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2015,” CA Cancer J. Clin. 65(1), 5–29 (2015).
[Crossref] [PubMed]

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

M. Singh, C. Wu, C.-H. Liu, J. Li, A. Schill, A. Nair, and K. V. Larin, “Phase-sensitive optical coherence elastography at 1.5 million A-Lines per second,” Opt. Lett. 40(11), 2588–2591 (2015).
[Crossref] [PubMed]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

2014 (7)

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Chin, A. Curatolo, B. F. Kennedy, B. J. Doyle, P. R. T. Munro, R. A. McLaughlin, and D. D. Sampson, “Analysis of image formation in optical coherence elastography using a multiphysics approach,” Biomed. Opt. Express 5(9), 2913–2930 (2014).
[Crossref] [PubMed]

S. Wang and K. V. Larin, “Noncontact depth-resolved micro-scale optical coherence elastography of the cornea,” Biomed. Opt. Express 5(11), 3807–3821 (2014).
[Crossref] [PubMed]

2013 (1)

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

2012 (5)

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

K. Esbona, Z. Li, and L. G. Wilke, “Intraoperative imprint cytology and frozen section pathology for margin assessment in breast conservation surgery: a systematic review,” Ann. Surg. Oncol. 19(10), 3236–3245 (2012).
[Crossref] [PubMed]

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

2011 (1)

2010 (2)

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

2009 (2)

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

2008 (1)

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

2007 (2)

T. P. Olson, J. Harter, A. Muñoz, D. M. Mahvi, and T. Breslin, “Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence,” Ann. Surg. Oncol. 14(10), 2953–2960 (2007).
[Crossref] [PubMed]

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

2006 (1)

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

2003 (1)

2002 (2)

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

S. E. Singletary, “Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy,” Am. J. Surg. 184(5), 383–393 (2002).
[Crossref] [PubMed]

2000 (2)

L. F. Smith, I. T. Rubio, R. Henry-Tillman, S. Korourian, and V. S. Klimberg, “Intraoperative ultrasound-guided breast biopsy,” Am. J. Surg. 180(6), 419–423 (2000).
[Crossref] [PubMed]

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

1998 (1)

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

1994 (1)

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Abner, A.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Adie, S. G.

Aguirre, A. D.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Ames, F. C.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Babiera, G. V.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Ballal, H.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Barbone, P. E.

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Bellafiore, F. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Bernstein, L.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Bisaillon, C.-E.

Boppart, S. A.

B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express 19(7), 6623–6634 (2011).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Bourke, A. G.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Breslin, T.

T. P. Olson, J. Harter, A. Muñoz, D. M. Mahvi, and T. Breslin, “Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence,” Ann. Surg. Oncol. 14(10), 2953–2960 (2007).
[Crossref] [PubMed]

Buchanan, M.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Buchholz, T. A.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Bush, M. B.

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

Cabioglu, N.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Caddy, C. M.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Cady, B.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Campbell, G.

Chaney, E. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Chen, R.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Chen, Z.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Chin, L.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

L. Chin, A. Curatolo, B. F. Kennedy, B. J. Doyle, P. R. T. Munro, R. A. McLaughlin, and D. D. Sampson, “Analysis of image formation in optical coherence elastography using a multiphysics approach,” Biomed. Opt. Express 5(9), 2913–2930 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Chou, L.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Chung, M.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Cohen, D. W.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Collins, J. P.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Connolly, J.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Connolly, J. L.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Cromwell, D. A.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Crowe, J. P.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Curatolo, A.

Dasari, R. R.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Desroches, J.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

DiPetrillo, T.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Doyle, B. J.

Es’haghian, S.

Esbona, K.

K. Esbona, Z. Li, and L. G. Wilke, “Intraoperative imprint cytology and frozen section pathology for margin assessment in breast conservation surgery: a systematic review,” Ann. Surg. Oncol. 19(10), 3236–3245 (2012).
[Crossref] [PubMed]

Feig, B. W.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Feld, M. S.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Fitzmaurice, M.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Ford, C.

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

Fujimoto, J. G.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Gardecki, J. A.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Garra, B. S.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Gelikonov, G. V.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

Gelman, R.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Gerstmann, D. K.

Gladkova, N. D.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

Goenezen, S.

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Gokhale, N. H.

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Graham, R. A.

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Gruen, R. L.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Gubarkova, E. V.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

Guiot, M.-C.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Haka, A. S.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Hall, T.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Hall, T. J.

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Hamza, S.

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

Harris, J. R.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Harter, J.

T. P. Olson, J. Harter, A. Muñoz, D. M. Mahvi, and T. Breslin, “Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence,” Ann. Surg. Oncol. 14(10), 2953–2960 (2007).
[Crossref] [PubMed]

Henry-Tillman, R.

L. F. Smith, I. T. Rubio, R. Henry-Tillman, S. Korourian, and V. S. Klimberg, “Intraoperative ultrasound-guided breast biopsy,” Am. J. Surg. 180(6), 419–423 (2000).
[Crossref] [PubMed]

Hetelekidis, S.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Hicks, D.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Homer, M. J.

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Hunt, K. K.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Jeevan, R.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Jemal, A.

R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2015,” CA Cancer J. Clin. 65(1), 5–29 (2015).
[Crossref] [PubMed]

Jermyn, M.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Jiang, J.

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Johnson, P. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Kallel, F.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Kane, D. J.

Kearins, O.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Kennedy, B. F.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

L. Chin, A. Curatolo, B. F. Kennedy, B. J. Doyle, P. R. T. Munro, R. A. McLaughlin, and D. D. Sampson, “Analysis of image formation in optical coherence elastography using a multiphysics approach,” Biomed. Opt. Express 5(9), 2913–2930 (2014).
[Crossref] [PubMed]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express 19(7), 6623–6634 (2011).
[Crossref] [PubMed]

Kennedy, K. M.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

Kirk, R. W.

Klimberg, V. S.

L. F. Smith, I. T. Rubio, R. Henry-Tillman, S. Korourian, and V. S. Klimberg, “Intraoperative ultrasound-guided breast biopsy,” Am. J. Surg. 180(6), 419–423 (2000).
[Crossref] [PubMed]

Koh, S. H.

Korourian, S.

L. F. Smith, I. T. Rubio, R. Henry-Tillman, S. Korourian, and V. S. Klimberg, “Intraoperative ultrasound-guided breast biopsy,” Am. J. Surg. 180(6), 419–423 (2000).
[Crossref] [PubMed]

Kotynek, J. G.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Krouskop, T. A.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Kuerer, H. M.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Kurniawan, E. D.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Lamouche, G.

Landa, M.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Larin, K. V.

Latham, B.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Lawrence, G.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Leblond, F.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Lee, H.-C.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Li, J.

Li, Z.

K. Esbona, Z. Li, and L. G. Wilke, “Intraoperative imprint cytology and frozen section pathology for margin assessment in breast conservation surgery: a systematic review,” Ann. Surg. Oncol. 19(10), 3236–3245 (2012).
[Crossref] [PubMed]

Liang, X.

Liu, C.-H.

Liu, G.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Lyons, J.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Mahvi, D. M.

T. P. Olson, J. Harter, A. Muñoz, D. M. Mahvi, and T. Breslin, “Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence,” Ann. Surg. Oncol. 14(10), 2953–2960 (2007).
[Crossref] [PubMed]

Malheiro, F. G.

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

Mann, G. B.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Marchant, D. J.

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Matveev, L. A.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

Matveyev, A. L.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

McLaughlin, R. A.

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

L. Chin, A. Curatolo, B. F. Kennedy, B. J. Doyle, P. R. T. Munro, R. A. McLaughlin, and D. D. Sampson, “Analysis of image formation in optical coherence elastography using a multiphysics approach,” Biomed. Opt. Express 5(9), 2913–2930 (2014).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

Mercier, J.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Meric-Bernstam, F.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Miller, J. A.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Miller, K. D.

R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2015,” CA Cancer J. Clin. 65(1), 5–29 (2015).
[Crossref] [PubMed]

Mitsumori, M.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Mok, K.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Mondelblatt, A. E.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Mou, A.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Muñoz, A.

T. P. Olson, J. Harter, A. Muñoz, D. M. Mahvi, and T. Breslin, “Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence,” Ann. Surg. Oncol. 14(10), 2953–2960 (2007).
[Crossref] [PubMed]

Munro, P. R. T.

Nair, A.

Nazemi, J.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Neuschatz, A. C.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Nguyen, F. T.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Nixon, A.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Oberai, A. A.

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Oliphant, U. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Olson, T. P.

T. P. Olson, J. Harter, A. Muñoz, D. M. Mahvi, and T. Breslin, “Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence,” Ann. Surg. Oncol. 14(10), 2953–2960 (2007).
[Crossref] [PubMed]

Park, C. C.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Pazos, V.

Pereira, J.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Peterson, K. A.

Petrecca, K.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Pichette, J.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Qi, W.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Quirk, B. C.

Recht, A.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Robbins, P.

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

Ronald, M.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

Rose, A.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Ross, M. I.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Rowland, K. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Rubio, I. T.

L. F. Smith, I. T. Rubio, R. Henry-Tillman, S. Korourian, and V. S. Klimberg, “Intraoperative ultrasound-guided breast biopsy,” Am. J. Surg. 180(6), 419–423 (2000).
[Crossref] [PubMed]

Safaii, H.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Sahin, A. A.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Saint-Arnaud, K.

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Sampson, D. D.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

R. W. Kirk, B. F. Kennedy, D. D. Sampson, and R. A. McLaughlin, “Near video-rate optical coherence elastography by acceleration with a graphics processing unit,” J. Lightwave Technol. 33(16), 3481–3485 (2015).
[Crossref]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

K. M. Kennedy, S. Es’haghian, L. Chin, R. A. McLaughlin, D. D. Sampson, and B. F. Kennedy, “Optical palpation: optical coherence tomography-based tactile imaging using a compliant sensor,” Opt. Lett. 39(10), 3014–3017 (2014).
[Crossref] [PubMed]

L. Chin, A. Curatolo, B. F. Kennedy, B. J. Doyle, P. R. T. Munro, R. A. McLaughlin, and D. D. Sampson, “Analysis of image formation in optical coherence elastography using a multiphysics approach,” Biomed. Opt. Express 5(9), 2913–2930 (2014).
[Crossref] [PubMed]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

B. F. Kennedy, S. H. Koh, R. A. McLaughlin, K. M. Kennedy, P. R. T. Munro, and D. D. Sampson, “Strain estimation in phase-sensitive optical coherence elastography,” Biomed. Opt. Express 3(8), 1865–1879 (2012).
[Crossref] [PubMed]

G. Lamouche, B. F. Kennedy, K. M. Kennedy, C.-E. Bisaillon, A. Curatolo, G. Campbell, V. Pazos, and D. D. Sampson, “Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography,” Biomed. Opt. Express 3(6), 1381–1398 (2012).
[Crossref] [PubMed]

B. F. Kennedy, X. Liang, S. G. Adie, D. K. Gerstmann, B. C. Quirk, S. A. Boppart, and D. D. Sampson, “In vivo three-dimensional optical coherence elastography,” Opt. Express 19(7), 6623–6634 (2011).
[Crossref] [PubMed]

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

Saunders, C.

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

Saunders, C. M.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

Schill, A.

Schmid, C. H.

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Schnitt, S. J.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Scolaro, L.

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

Sheppard, C.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Siegel, R. L.

R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2015,” CA Cancer J. Clin. 65(1), 5–29 (2015).
[Crossref] [PubMed]

Sigler, C. J.

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Silver, B.

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

Singh, M.

Singletary, S. E.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

S. E. Singletary, “Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy,” Am. J. Surg. 184(5), 383–393 (2002).
[Crossref] [PubMed]

Smith, L. F.

L. F. Smith, I. T. Rubio, R. Henry-Tillman, S. Korourian, and V. S. Klimberg, “Intraoperative ultrasound-guided breast biopsy,” Am. J. Surg. 180(6), 419–423 (2000).
[Crossref] [PubMed]

Smith, T. J.

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Sommer, A. M.

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Steinhoff, M.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Taylor, D. B.

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Tien, A.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, A. Curatolo, A. Tien, B. Latham, C. M. Saunders, and D. D. Sampson, “Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure,” Biomed. Opt. Express 5(7), 2113–2124 (2014).
[Crossref] [PubMed]

Trivella, M.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Tsai, T.-H.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Vakhtin, A. B.

van der Meulen, J. H.

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

Vitkin, A.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

Volynskaya, Z.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Wang, S.

Wang, Y.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Wazer, D. E.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Wheeler, T. M.

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Whitman, G. J.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Wijesinghe, P.

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

Wilke, L. G.

K. Esbona, Z. Li, and L. G. Wilke, “Intraoperative imprint cytology and frozen section pathology for margin assessment in breast conservation surgery: a systematic review,” Ann. Surg. Oncol. 19(10), 3236–3245 (2012).
[Crossref] [PubMed]

Windle, I.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Wong, M. H.

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

Wood, W. R.

Wu, C.

Yunes, M.

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Zaitsev, V. Y.

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

Zhang, J.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Zhou, C.

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

Zhou, Q.

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

Zysk, A. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

AJR Am. J. Roentgenol. (1)

R. A. Graham, M. J. Homer, C. J. Sigler, H. Safaii, C. H. Schmid, D. J. Marchant, and T. J. Smith, “The efficacy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma,” AJR Am. J. Roentgenol. 162(1), 33–36 (1994).
[Crossref] [PubMed]

Am. J. Surg. (2)

L. F. Smith, I. T. Rubio, R. Henry-Tillman, S. Korourian, and V. S. Klimberg, “Intraoperative ultrasound-guided breast biopsy,” Am. J. Surg. 180(6), 419–423 (2000).
[Crossref] [PubMed]

S. E. Singletary, “Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy,” Am. J. Surg. 184(5), 383–393 (2002).
[Crossref] [PubMed]

Ann. Surg. Oncol. (4)

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

E. D. Kurniawan, M. H. Wong, I. Windle, A. Rose, A. Mou, M. Buchanan, J. P. Collins, J. A. Miller, R. L. Gruen, and G. B. Mann, “Predictors of surgical margin status in breast-conserving surgery within a breast screening program,” Ann. Surg. Oncol. 15(9), 2542–2549 (2008).
[Crossref] [PubMed]

T. P. Olson, J. Harter, A. Muñoz, D. M. Mahvi, and T. Breslin, “Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence,” Ann. Surg. Oncol. 14(10), 2953–2960 (2007).
[Crossref] [PubMed]

K. Esbona, Z. Li, and L. G. Wilke, “Intraoperative imprint cytology and frozen section pathology for margin assessment in breast conservation surgery: a systematic review,” Ann. Surg. Oncol. 19(10), 3236–3245 (2012).
[Crossref] [PubMed]

ANZ J. Surg. (1)

H. Ballal, D. B. Taylor, A. G. Bourke, B. Latham, and C. M. Saunders, “Predictors of re-excision in wire-guided wide local excision for early breast cancer: a Western Australian multi-centre experience,” ANZ J. Surg. 85(7-8), 540–545 (2015).
[Crossref] [PubMed]

Appl. Opt. (1)

Biomed. Opt. Express (5)

BMJ (1)

R. Jeevan, D. A. Cromwell, M. Trivella, G. Lawrence, O. Kearins, J. Pereira, C. Sheppard, C. M. Caddy, and J. H. van der Meulen, “Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics,” BMJ 345jul 12 2, e4505 (2012).
[Crossref] [PubMed]

CA Cancer J. Clin. (1)

R. L. Siegel, K. D. Miller, and A. Jemal, “Cancer statistics, 2015,” CA Cancer J. Clin. 65(1), 5–29 (2015).
[Crossref] [PubMed]

Cancer (1)

A. C. Neuschatz, T. DiPetrillo, M. Steinhoff, H. Safaii, M. Yunes, M. Landa, M. Chung, B. Cady, and D. E. Wazer, “The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast,” Cancer 94(7), 1917–1924 (2002).
[Crossref] [PubMed]

Cancer Res. (5)

B. F. Kennedy, R. A. McLaughlin, K. M. Kennedy, L. Chin, P. Wijesinghe, A. Curatolo, A. Tien, M. Ronald, B. Latham, C. M. Saunders, and D. D. Sampson, “Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue,” Cancer Res. 75(16), 3236–3245 (2015).
[Crossref] [PubMed]

R. A. McLaughlin, L. Scolaro, P. Robbins, S. Hamza, C. Saunders, and D. D. Sampson, “Imaging of human lymph nodes using optical coherence tomography: potential for staging cancer,” Cancer Res. 70(7), 2579–2584 (2010).
[Crossref] [PubMed]

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

C. Zhou, D. W. Cohen, Y. Wang, H.-C. Lee, A. E. Mondelblatt, T.-H. Tsai, A. D. Aguirre, J. G. Fujimoto, and J. L. Connolly, “Integrated optical coherence tomography and microscopy for ex vivo multiscale evaluation of human breast tissues,” Cancer Res. 70(24), 10071–10079 (2010).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

B. F. Kennedy, K. M. Kennedy, and D. D. Sampson, “A Review of Optical Coherence Elastography: Fundamentals, Techniques and Prospects,” IEEE J. Sel. Top. Quantum Electron. 20(2), 7101217 (2014).
[Crossref]

J. Biomed. Opt. (3)

W. Qi, R. Chen, L. Chou, G. Liu, J. Zhang, Q. Zhou, and Z. Chen, “Phase-resolved acoustic radiation force optical coherence elastography,” J. Biomed. Opt. 17(11), 110505 (2012).
[Crossref] [PubMed]

K. M. Kennedy, C. Ford, B. F. Kennedy, M. B. Bush, and D. D. Sampson, “Analysis of mechanical contrast in optical coherence elastography,” J. Biomed. Opt. 18(12), 121508 (2013).
[Crossref] [PubMed]

B. F. Kennedy, F. G. Malheiro, L. Chin, and D. D. Sampson, “Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans,” J. Biomed. Opt. 19(7), 076006 (2014).
[Crossref] [PubMed]

J. Biophotonics (1)

V. Y. Zaitsev, A. L. Matveyev, L. A. Matveev, G. V. Gelikonov, E. V. Gubarkova, N. D. Gladkova, and A. Vitkin, “Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking,” J. Biophotonics 9(5), 499–509 (2016).
[Crossref] [PubMed]

J. Clin. Oncol. (1)

C. C. Park, M. Mitsumori, A. Nixon, A. Recht, J. Connolly, R. Gelman, B. Silver, S. Hetelekidis, A. Abner, J. R. Harris, and S. J. Schnitt, “Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence,” J. Clin. Oncol. 18(8), 1668–1675 (2000).
[PubMed]

J. Lightwave Technol. (1)

Opt. Express (1)

Opt. Lett. (2)

Photonics Lasers Med. (1)

L. Scolaro, R. A. McLaughlin, B. F. Kennedy, C. M. Saunders, and D. D. Sampson, “A review of optical coherence tomography in breast cancer,” Photonics Lasers Med. 3(3), 225–240 (2014).
[Crossref]

Phys. Med. Biol. (1)

A. A. Oberai, N. H. Gokhale, S. Goenezen, P. E. Barbone, T. J. Hall, A. M. Sommer, and J. Jiang, “Linear and nonlinear elasticity imaging of soft tissue in vivo: demonstration of feasibility,” Phys. Med. Biol. 54(5), 1191–1207 (2009).
[Crossref] [PubMed]

Sci. Rep. (1)

K. M. Kennedy, L. Chin, R. A. McLaughlin, B. Latham, C. M. Saunders, D. D. Sampson, and B. F. Kennedy, “Quantitative micro-elastography: imaging of tissue elasticity using compression optical coherence elastography,” Sci. Rep. 5, 15538 (2015).
[Crossref] [PubMed]

Sci. Transl. Med. (1)

M. Jermyn, K. Mok, J. Mercier, J. Desroches, J. Pichette, K. Saint-Arnaud, L. Bernstein, M.-C. Guiot, K. Petrecca, and F. Leblond, “Intraoperative brain cancer detection with Raman spectroscopy in humans,” Sci. Transl. Med. 7(274), 274ra19 (2015).
[Crossref] [PubMed]

Ultrason. Imaging (1)

T. A. Krouskop, T. M. Wheeler, F. Kallel, B. S. Garra, and T. Hall, “Elastic moduli of breast and prostate tissues under compression,” Ultrason. Imaging 20(4), 260–274 (1998).
[Crossref] [PubMed]

Other (2)

“Breast Cancer Facts & Figures 2015-2016” (American Cancer Society, 2015), retrieved http://www.cancer.org/acs/groups/content/@research/documents/document/acspc-046381.pdf .

W. Dexter and J. G. Fujimoto, Eds, Optical Coherence Tomography: Technology and Applications, 2nd ed. (Springer International Publishing, 2015), Chap. 32.

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Figures (7)

Fig. 1
Fig. 1

Wide-field OCME system with main components labelled.

Fig. 2
Fig. 2

Wide-field OCME of a tissue mimicking silicone phantom. (a) Photograph of phantom showing position of stiff inclusions. The white square indicates the area imaged using OCT and OCME. (b) Wide-field en face OCT image of phantom taken at a depth of 400 µm. (c) Wide-field en face elastogram of phantom taken at a depth of 400 µm.

Fig. 3
Fig. 3

Illustration of the overlay process. (a) Wide-field OCT image. (b) Cropped OCT image, generated by combining (a) and (d). (c) Binary mask. (d) Unmodified wide-field elastogram. (e) Masked elastogram, generated by multiplying (c) and (d), (white area corresponds to transparent in the overlay). (f) Wide-field OCT/OCME, generated by overlaying (e) onto (a). Scale bar 10 mm.

Fig. 4
Fig. 4

Wide-field OCME of a freshly excised benign tumor. (a) Wide-field en face OCME overlay on OCT of benign tumor (b) Photograph of excised tissue. (c) En face OCT image showing a 1.6× magnification of the boxed region in (a). (d) Corresponding en face OCME overlay. A, adipose; S, stroma; and P, intraductal papilloma.

Fig. 5
Fig. 5

Wide-field OCME of a freshly excised malignant tumor. (a) Wide-field en face OCME overlay on OCT of the entire sample, measuring 47.5 × 47.5 mm. (b) Histology, co-registered with OCT and OCME image. (The white horizontal artifact at top is due to stitching images taken from tissue in two histology cassettes.) (c) En face OCT image showing a 1.6× magnification of the boxed region in (a). (d) Corresponding en face OCME overlay. A, adipose; C, cassette stitching artifact; D, dense tissue; NC, non-contact; S, stroma; and T, tumor.

Fig. 6
Fig. 6

Wide-field OCME of a freshly excised lumpectomy. (a) Wide-field en face OCME overlay on OCT of lumpectomy. (b) Histology acquired in orthogonal plane to OCT/OCME from region indicated by green dashed line found to contain clear margin. (c) En face OCT image showing a 1.6× magnification of the green boxed region in (a). (d) Corresponding en face overlay. (e) Histology acquired in orthogonal plane to OCT/OCME from region indicated by red dashed line found to contain involved margin. (f) En face OCT image showing a 1.6× magnification of the blue boxed region. (g) Corresponding en face overlay. Note: Histology is taken in the plane orthogonal to en face images, with the imaging beam direction indicated by blue arrows. A, adipose; S, stroma; and T, tumor.

Fig. 7
Fig. 7

Wide-field OCME of a freshly excised cavity shaving. (a) Wide-field en face OCME overlay on OCT of cavity shaving, black regions correspond to areas of noncontact or absence of tissue. (b) Photograph of sample. (c) En face OCT image showing a 1.6× magnification of boxed region in (a). (d) Corresponding en face OCME overlay. A, adipose; and S, stroma.

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