Abstract

The non-invasive measurement of blood oxygen saturation in blood vessels is a promising clinical application of optoacoustic imaging. Nevertheless, precise optoacoustic measurements of blood oxygen saturation are limited because of the complexities of calculating the spatial distribution of the optical fluence. In the paper error in the determination of blood oxygen saturation, associated with the use of approximate methods of optical fluence evaluation within the blood vessel, was investigated for optoacoustic measurements at two wavelengths. The method takes into account both acoustic pressure noise and the error in determined values of the optical scattering and absorption coefficients used for the calculation of the fluence. It is shown that, in conditions of an unknown (or partially known) spatial distribution of fluence at depths of 2 to 8 mm, minimal error in the determination of blood oxygen saturation is achieved at wavelengths of 658 ± 40 nm and 1069 ± 40 nm.

© 2016 Optical Society of America

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2016 (2)

P. Subochev, “Cost-effective imaging of optoacoustic pressure, ultrasonic scattering, and optical diffuse reflectance with improved resolution and speed,” Opt. Lett. 41(5), 1006–1009 (2016).
[Crossref] [PubMed]

P. Subochev, I. Fiks, M. Frenz, and Turchin, “Simultaneous triple-modality imaging of diffuse reflectance, optoacoustic pressure and ultrasonic scattering using an acoustic-resolution photoacoustic microscope: feasibility study,” Laser Phys. Lett. 13(2), 025605 (2016).
[Crossref]

2015 (3)

P. Subochev, A. Orlova, M. Shirmanova, A. Postnikova, and I. Turchin, “Simultaneous photoacoustic and optically mediated ultrasound microscopy: an in vivo study,” Biomed. Opt. Express 6(2), 631–638 (2015).
[Crossref] [PubMed]

S. Gottschalk, T. F. Fehm, X. L. Deán-Ben, and D. Razansky, “Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography,” J. Cereb. Blood Flow Metab. 35(4), 531–535 (2015).
[Crossref] [PubMed]

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

2014 (3)

C. Darne, Y. Lu, and E. M. Sevick-Muraca, “Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update,” Phys. Med. Biol. 59(1), R1–R64 (2014).
[Crossref] [PubMed]

C. Lutzweiler, R. Meier, E. Rummeny, V. Ntziachristos, and D. Razansky, “Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature,” Opt. Lett. 39(14), 4061–4064 (2014).
[Crossref] [PubMed]

J. Yao and L. V. Wang, “Sensitivity of photoacoustic microscopy,” Photoacoustics 2(2), 87–101 (2014).
[Crossref] [PubMed]

2013 (3)

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
[Crossref] [PubMed]

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

2012 (6)

I. Y. Petrov, Y. Petrov, D. S. Prough, I. Cicenaite, D. J. Deyo, and R. O. Esenaliev, “Optoacoustic monitoring of cerebral venous blood oxygenation though intact scalp in large animals,” Opt. Express 20(4), 4159–4167 (2012).
[Crossref] [PubMed]

Y. Jiang, A. Forbrich, T. Harrison, and R. J. Zemp, “Blood oxygen flux estimation with a combined photoacoustic and high-frequency ultrasound microscopy system: a phantom study,” J. Biomed. Opt. 17(3), 036012 (2012).
[Crossref] [PubMed]

L. Xi, X. Li, L. Yao, S. Grobmyer, and H. Jiang, “Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection,” Med. Phys. 39(5), 2584–2594 (2012).
[Crossref] [PubMed]

Z. Chen, S. Yang, and D. Xing, “In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation with multiwavelength photoacoustic microscopy,” Opt. Lett. 37(16), 3414–3416 (2012).
[Crossref] [PubMed]

B. Cox, J. G. Laufer, S. R. Arridge, and P. C. Beard, “Quantitative spectroscopic photoacoustic imaging: a review,” J. Biomed. Opt. 17(6), 061202 (2012).
[Crossref] [PubMed]

G. P. Luke, D. Yeager, and S. Y. Emelianov, “Biomedical applications of photoacoustic imaging with exogenous contrast agents,” Ann. Biomed. Eng. 40(2), 422–437 (2012).
[Crossref] [PubMed]

2011 (1)

2010 (5)

J. Xiao, Z. Yuan, J. He, and H. Jiang, “Quantitative multispectral photoacoustic tomography and wavelength optimization,” J. XRay Sci. Technol. 18(4), 415–427 (2010).
[PubMed]

S. L. Jacques, “How tissue optics affect dosimetry of photodynamic therapy,” J. Biomed. Opt. 15(5), 051608 (2010).
[Crossref] [PubMed]

D. Modgil and P. J. La Riviére, “Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound,” Phys. Med. Biol. 55(23), 7231–7251 (2010).
[Crossref] [PubMed]

V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods 7(8), 603–614 (2010).
[Crossref] [PubMed]

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

2009 (3)

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[Crossref] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

2007 (6)

G. Paltauf, R. Nuster, M. Haltmeier, and P. Burgholzer, “Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector,” Appl. Opt. 46(16), 3352–3358 (2007).
[Crossref] [PubMed]

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007).
[Crossref]

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

C. M. Carpenter, B. W. Pogue, S. Jiang, H. Dehghani, X. Wang, K. D. Paulsen, W. A. Wells, J. Forero, C. Kogel, J. B. Weaver, S. P. Poplack, and P. A. Kaufman, “Image-guided optical spectroscopy provides molecular-specific information in vivo: MRI-guided spectroscopy of breast cancer hemoglobin, water, and scatterer size,” Opt. Lett. 32(8), 933–935 (2007).
[Crossref] [PubMed]

2005 (5)

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

C. Menon and D. L. Fraker, “Tumor oxygenation status as a prognostic marker,” Cancer Lett. 221(2), 225–235 (2005).
[Crossref] [PubMed]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

J. Laufer, C. Elwell, D. Delpy, and P. Beard, “In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution,” Phys. Med. Biol. 50(18), 4409–4428 (2005).
[Crossref] [PubMed]

A. Bashkatov, E. Genina, V. Kochubey, and V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

2004 (2)

A. A. Tandara and T. A. Mustoe, “Oxygen in wound healing--more than a nutrient,” World J. Surg. 28(3), 294–300 (2004).
[Crossref] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

2003 (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Alqasemi, U.

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

Arnal, B.

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Arridge, S. R.

B. Cox, J. G. Laufer, S. R. Arridge, and P. C. Beard, “Quantitative spectroscopic photoacoustic imaging: a review,” J. Biomed. Opt. 17(6), 061202 (2012).
[Crossref] [PubMed]

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

Bashkatov, A.

A. Bashkatov, E. Genina, V. Kochubey, and V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

Beard, P.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

J. Laufer, C. Elwell, D. Delpy, and P. Beard, “In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution,” Phys. Med. Biol. 50(18), 4409–4428 (2005).
[Crossref] [PubMed]

Beard, P. C.

B. Cox, J. G. Laufer, S. R. Arridge, and P. C. Beard, “Quantitative spectroscopic photoacoustic imaging: a review,” J. Biomed. Opt. 17(6), 061202 (2012).
[Crossref] [PubMed]

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[Crossref] [PubMed]

Bevilacqua, F.

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

Burgholzer, P.

Butler, J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

Carpenter, C. M.

Cerussi, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Cerussi, A. E.

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

Chao, P. C.-P.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Chen, Y.-Y.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Chen, Z.

Choe, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Cicenaite, I.

Cox, B.

B. Cox, J. G. Laufer, S. R. Arridge, and P. C. Beard, “Quantitative spectroscopic photoacoustic imaging: a review,” J. Biomed. Opt. 17(6), 061202 (2012).
[Crossref] [PubMed]

Darne, C.

C. Darne, Y. Lu, and E. M. Sevick-Muraca, “Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update,” Phys. Med. Biol. 59(1), R1–R64 (2014).
[Crossref] [PubMed]

Deán-Ben, X. L.

S. Gottschalk, T. F. Fehm, X. L. Deán-Ben, and D. Razansky, “Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography,” J. Cereb. Blood Flow Metab. 35(4), 531–535 (2015).
[Crossref] [PubMed]

Dehghani, H.

Delpy, D.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

J. Laufer, C. Elwell, D. Delpy, and P. Beard, “In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution,” Phys. Med. Biol. 50(18), 4409–4428 (2005).
[Crossref] [PubMed]

Deyo, D. J.

Distel, M.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Durduran, T.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Durkin, A.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Elwell, C.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

J. Laufer, C. Elwell, D. Delpy, and P. Beard, “In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution,” Phys. Med. Biol. 50(18), 4409–4428 (2005).
[Crossref] [PubMed]

Emelianov, S. Y.

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

G. P. Luke, D. Yeager, and S. Y. Emelianov, “Biomedical applications of photoacoustic imaging with exogenous contrast agents,” Ann. Biomed. Eng. 40(2), 422–437 (2012).
[Crossref] [PubMed]

Esenaliev, R. O.

Evers, D. J.

Fehm, T. F.

S. Gottschalk, T. F. Fehm, X. L. Deán-Ben, and D. Razansky, “Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography,” J. Cereb. Blood Flow Metab. 35(4), 531–535 (2015).
[Crossref] [PubMed]

Fiks, I.

P. Subochev, I. Fiks, M. Frenz, and Turchin, “Simultaneous triple-modality imaging of diffuse reflectance, optoacoustic pressure and ultrasonic scattering using an acoustic-resolution photoacoustic microscope: feasibility study,” Laser Phys. Lett. 13(2), 025605 (2016).
[Crossref]

Forbrich, A.

Y. Jiang, A. Forbrich, T. Harrison, and R. J. Zemp, “Blood oxygen flux estimation with a combined photoacoustic and high-frequency ultrasound microscopy system: a phantom study,” J. Biomed. Opt. 17(3), 036012 (2012).
[Crossref] [PubMed]

Forero, J.

Fraker, D. L.

C. Menon and D. L. Fraker, “Tumor oxygenation status as a prognostic marker,” Cancer Lett. 221(2), 225–235 (2005).
[Crossref] [PubMed]

Frenz, M.

P. Subochev, I. Fiks, M. Frenz, and Turchin, “Simultaneous triple-modality imaging of diffuse reflectance, optoacoustic pressure and ultrasonic scattering using an acoustic-resolution photoacoustic microscope: feasibility study,” Laser Phys. Lett. 13(2), 025605 (2016).
[Crossref]

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Genina, E.

A. Bashkatov, E. Genina, V. Kochubey, and V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

Gibson, A. P.

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

Gottschalk, S.

S. Gottschalk, T. F. Fehm, X. L. Deán-Ben, and D. Razansky, “Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography,” J. Cereb. Blood Flow Metab. 35(4), 531–535 (2015).
[Crossref] [PubMed]

Grobmyer, S.

L. Xi, X. Li, L. Yao, S. Grobmyer, and H. Jiang, “Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection,” Med. Phys. 39(5), 2584–2594 (2012).
[Crossref] [PubMed]

Haltmeier, M.

Harrison, T.

Y. Jiang, A. Forbrich, T. Harrison, and R. J. Zemp, “Blood oxygen flux estimation with a combined photoacoustic and high-frequency ultrasound microscopy system: a phantom study,” J. Biomed. Opt. 17(3), 036012 (2012).
[Crossref] [PubMed]

He, J.

J. Xiao, Z. Yuan, J. He, and H. Jiang, “Quantitative multispectral photoacoustic tomography and wavelength optimization,” J. XRay Sci. Technol. 18(4), 415–427 (2010).
[PubMed]

Hebden, J. C.

A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
[Crossref] [PubMed]

Hendriks, B. H. W.

Hsiang, D.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

Jacques, S. L.

S. L. Jacques, “Optical properties of biological tissues: a review,” Phys. Med. Biol. 58(11), R37–R61 (2013).
[Crossref] [PubMed]

S. L. Jacques, “How tissue optics affect dosimetry of photodynamic therapy,” J. Biomed. Opt. 15(5), 051608 (2010).
[Crossref] [PubMed]

Jaeger, M.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Jakubowski, D. B.

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

Jaw, F.-S.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Jiang, H.

L. Xi, X. Li, L. Yao, S. Grobmyer, and H. Jiang, “Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection,” Med. Phys. 39(5), 2584–2594 (2012).
[Crossref] [PubMed]

J. Xiao, Z. Yuan, J. He, and H. Jiang, “Quantitative multispectral photoacoustic tomography and wavelength optimization,” J. XRay Sci. Technol. 18(4), 415–427 (2010).
[PubMed]

Jiang, S.

Jiang, Y.

Y. Jiang, A. Forbrich, T. Harrison, and R. J. Zemp, “Blood oxygen flux estimation with a combined photoacoustic and high-frequency ultrasound microscopy system: a phantom study,” J. Biomed. Opt. 17(3), 036012 (2012).
[Crossref] [PubMed]

Kaufman, P. A.

Kochubey, V.

A. Bashkatov, E. Genina, V. Kochubey, and V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

Kogel, C.

Köster, R. W.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Ku, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Kumavor, P. D.

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

La Riviére, P. J.

D. Modgil and P. J. La Riviére, “Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound,” Phys. Med. Biol. 55(23), 7231–7251 (2010).
[Crossref] [PubMed]

Lai, H.-Y.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Laufer, J.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

J. Laufer, C. Elwell, D. Delpy, and P. Beard, “In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution,” Phys. Med. Biol. 50(18), 4409–4428 (2005).
[Crossref] [PubMed]

Laufer, J. G.

B. Cox, J. G. Laufer, S. R. Arridge, and P. C. Beard, “Quantitative spectroscopic photoacoustic imaging: a review,” J. Biomed. Opt. 17(6), 061202 (2012).
[Crossref] [PubMed]

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[Crossref] [PubMed]

Lemor, R.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Li, H.

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

Li, M.-L.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Li, X.

L. Xi, X. Li, L. Yao, S. Grobmyer, and H. Jiang, “Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection,” Med. Phys. 39(5), 2584–2594 (2012).
[Crossref] [PubMed]

Liao, L.-D.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Lin, C.-T.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Lo, Y.-C.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Lu, Y.

C. Darne, Y. Lu, and E. M. Sevick-Muraca, “Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update,” Phys. Med. Biol. 59(1), R1–R64 (2014).
[Crossref] [PubMed]

Lucassen, G. W.

Luke, G. P.

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

G. P. Luke, D. Yeager, and S. Y. Emelianov, “Biomedical applications of photoacoustic imaging with exogenous contrast agents,” Ann. Biomed. Eng. 40(2), 422–437 (2012).
[Crossref] [PubMed]

Lutzweiler, C.

Ma, R.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Maslov, K.

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007).
[Crossref]

Mehta, R.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Meier, R.

Menon, C.

C. Menon and D. L. Fraker, “Tumor oxygenation status as a prognostic marker,” Cancer Lett. 221(2), 225–235 (2005).
[Crossref] [PubMed]

Modgil, D.

D. Modgil and P. J. La Riviére, “Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound,” Phys. Med. Biol. 55(23), 7231–7251 (2010).
[Crossref] [PubMed]

Mustoe, T. A.

A. A. Tandara and T. A. Mustoe, “Oxygen in wound healing--more than a nutrient,” World J. Surg. 28(3), 294–300 (2004).
[Crossref] [PubMed]

Nachabé, R.

Nam, S. Y.

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

Nguyen, T.-M.

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Niederhauser, J. J.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Ntziachristos, V.

C. Lutzweiler, R. Meier, E. Rummeny, V. Ntziachristos, and D. Razansky, “Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature,” Opt. Lett. 39(14), 4061–4064 (2014).
[Crossref] [PubMed]

V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods 7(8), 603–614 (2010).
[Crossref] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Nuster, R.

O’Donnell, M.

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Orlova, A.

Paltauf, G.

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Paulsen, K. D.

Pedley, R. B.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[Crossref] [PubMed]

Pelivanov, I. M.

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Perrimon, N.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Petrov, I. Y.

Petrov, Y.

Pogue, B. W.

Poplack, S. P.

Postnikova, A.

Prough, D. S.

Razansky, D.

S. Gottschalk, T. F. Fehm, X. L. Deán-Ben, and D. Razansky, “Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography,” J. Cereb. Blood Flow Metab. 35(4), 531–535 (2015).
[Crossref] [PubMed]

C. Lutzweiler, R. Meier, E. Rummeny, V. Ntziachristos, and D. Razansky, “Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature,” Opt. Lett. 39(14), 4061–4064 (2014).
[Crossref] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Ruers, T. J. M.

Rummeny, E.

Sevick-Muraca, E. M.

C. Darne, Y. Lu, and E. M. Sevick-Muraca, “Small animal fluorescence and bioluminescence tomography: a review of approaches, algorithms and technology update,” Phys. Med. Biol. 59(1), R1–R64 (2014).
[Crossref] [PubMed]

Shah, N.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

Shih, Y.-Y. I.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Shirmanova, M.

Sivaramakrishnan, M.

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007).
[Crossref]

Stoica, G.

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007).
[Crossref]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Subochev, P.

Tandara, A. A.

A. A. Tandara and T. A. Mustoe, “Oxygen in wound healing--more than a nutrient,” World J. Surg. 28(3), 294–300 (2004).
[Crossref] [PubMed]

Tromberg, B. J.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

Tsang, S.

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Tuchin, V.

A. Bashkatov, E. Genina, V. Kochubey, and V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

Turchin,

P. Subochev, I. Fiks, M. Frenz, and Turchin, “Simultaneous triple-modality imaging of diffuse reflectance, optoacoustic pressure and ultrasonic scattering using an acoustic-resolution photoacoustic microscope: feasibility study,” Laser Phys. Lett. 13(2), 025605 (2016).
[Crossref]

Turchin, I.

van der Voort, M.

Vinegoni, C.

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Wang, L. V.

J. Yao and L. V. Wang, “Sensitivity of photoacoustic microscopy,” Photoacoustics 2(2), 87–101 (2014).
[Crossref] [PubMed]

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007).
[Crossref]

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Wang, X.

Weaver, J. B.

Weber, P.

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

Wei, C.-W.

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Wells, W. A.

Wesseling, J.

Wong, E. Y.

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Xi, L.

L. Xi, X. Li, L. Yao, S. Grobmyer, and H. Jiang, “Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection,” Med. Phys. 39(5), 2584–2594 (2012).
[Crossref] [PubMed]

Xia, J.

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Xiao, J.

J. Xiao, Z. Yuan, J. He, and H. Jiang, “Quantitative multispectral photoacoustic tomography and wavelength optimization,” J. XRay Sci. Technol. 18(4), 415–427 (2010).
[PubMed]

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Xing, D.

Xu, C.

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

Xu, Y.

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

Yang, S.

Yao, J.

J. Yao and L. V. Wang, “Sensitivity of photoacoustic microscopy,” Photoacoustics 2(2), 87–101 (2014).
[Crossref] [PubMed]

Yao, L.

L. Xi, X. Li, L. Yao, S. Grobmyer, and H. Jiang, “Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection,” Med. Phys. 39(5), 2584–2594 (2012).
[Crossref] [PubMed]

Yeager, D.

G. P. Luke, D. Yeager, and S. Y. Emelianov, “Biomedical applications of photoacoustic imaging with exogenous contrast agents,” Ann. Biomed. Eng. 40(2), 422–437 (2012).
[Crossref] [PubMed]

Yodh, A. G.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Yu, G.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Yuan, Z.

J. Xiao, Z. Yuan, J. He, and H. Jiang, “Quantitative multispectral photoacoustic tomography and wavelength optimization,” J. XRay Sci. Technol. 18(4), 415–427 (2010).
[PubMed]

Zanganeh, S.

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

Zemp, R. J.

Y. Jiang, A. Forbrich, T. Harrison, and R. J. Zemp, “Blood oxygen flux estimation with a combined photoacoustic and high-frequency ultrasound microscopy system: a phantom study,” J. Biomed. Opt. 17(3), 036012 (2012).
[Crossref] [PubMed]

Zhang, E. Z.

E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009).
[Crossref] [PubMed]

Zhang, H. F.

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007).
[Crossref]

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

Zhou, C.

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

Zhu, Q.

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

Ann. Biomed. Eng. (1)

G. P. Luke, D. Yeager, and S. Y. Emelianov, “Biomedical applications of photoacoustic imaging with exogenous contrast agents,” Ann. Biomed. Eng. 40(2), 422–437 (2012).
[Crossref] [PubMed]

Appl. Opt. (1)

Appl. Phys. Lett. (1)

H. F. Zhang, K. Maslov, M. Sivaramakrishnan, G. Stoica, and L. V. Wang, “Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy,” Appl. Phys. Lett. 90(5), 053901 (2007).
[Crossref]

Biomed. Opt. Express (2)

Cancer Lett. (1)

C. Menon and D. L. Fraker, “Tumor oxygenation status as a prognostic marker,” Cancer Lett. 221(2), 225–235 (2005).
[Crossref] [PubMed]

IEEE Trans. Med. Imaging (1)

J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005).
[Crossref] [PubMed]

IEEE Trans. Ultrason. Ferroelectr. Freq. Control (1)

C.-W. Wei, T.-M. Nguyen, J. Xia, B. Arnal, E. Y. Wong, I. M. Pelivanov, and M. O’Donnell, “Real-time integrated photoacoustic and ultrasound (PAUS) imaging system to guide interventional procedures: ex vivo study,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control 62(2), 319–328 (2015).
[Crossref] [PubMed]

Inverse Probl. (1)

K. Maslov, H. F. Zhang, and L. V. Wang, “Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo,” Inverse Probl. 23(6), S113–S122 (2007).
[Crossref]

J. Biomed. Opt. (6)

B. Cox, J. G. Laufer, S. R. Arridge, and P. C. Beard, “Quantitative spectroscopic photoacoustic imaging: a review,” J. Biomed. Opt. 17(6), 061202 (2012).
[Crossref] [PubMed]

Y. Jiang, A. Forbrich, T. Harrison, and R. J. Zemp, “Blood oxygen flux estimation with a combined photoacoustic and high-frequency ultrasound microscopy system: a phantom study,” J. Biomed. Opt. 17(3), 036012 (2012).
[Crossref] [PubMed]

C. Zhou, R. Choe, N. Shah, T. Durduran, G. Yu, A. Durkin, D. Hsiang, R. Mehta, J. Butler, A. Cerussi, B. J. Tromberg, and A. G. Yodh, “Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy,” J. Biomed. Opt. 12(5), 051903 (2007).
[Crossref] [PubMed]

D. B. Jakubowski, A. E. Cerussi, F. Bevilacqua, N. Shah, D. Hsiang, J. Butler, and B. J. Tromberg, “Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study,” J. Biomed. Opt. 9(1), 230–238 (2004).
[Crossref] [PubMed]

S. L. Jacques, “How tissue optics affect dosimetry of photodynamic therapy,” J. Biomed. Opt. 15(5), 051608 (2010).
[Crossref] [PubMed]

C. Xu, P. D. Kumavor, U. Alqasemi, H. Li, Y. Xu, S. Zanganeh, and Q. Zhu, “Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography,” J. Biomed. Opt. 18(12), 126006 (2013).
[Crossref] [PubMed]

J. Cereb. Blood Flow Metab. (1)

S. Gottschalk, T. F. Fehm, X. L. Deán-Ben, and D. Razansky, “Noninvasive real-time visualization of multiple cerebral hemodynamic parameters in whole mouse brains using five-dimensional optoacoustic tomography,” J. Cereb. Blood Flow Metab. 35(4), 531–535 (2015).
[Crossref] [PubMed]

J. Phys. D Appl. Phys. (1)

A. Bashkatov, E. Genina, V. Kochubey, and V. Tuchin, “Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm,” J. Phys. D Appl. Phys. 38(15), 2543–2555 (2005).
[Crossref]

J. XRay Sci. Technol. (1)

J. Xiao, Z. Yuan, J. He, and H. Jiang, “Quantitative multispectral photoacoustic tomography and wavelength optimization,” J. XRay Sci. Technol. 18(4), 415–427 (2010).
[PubMed]

Laser Phys. Lett. (1)

P. Subochev, I. Fiks, M. Frenz, and Turchin, “Simultaneous triple-modality imaging of diffuse reflectance, optoacoustic pressure and ultrasonic scattering using an acoustic-resolution photoacoustic microscope: feasibility study,” Laser Phys. Lett. 13(2), 025605 (2016).
[Crossref]

Med. Phys. (1)

L. Xi, X. Li, L. Yao, S. Grobmyer, and H. Jiang, “Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection,” Med. Phys. 39(5), 2584–2594 (2012).
[Crossref] [PubMed]

Nat. Biotechnol. (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Nat. Methods (1)

V. Ntziachristos, “Going deeper than microscopy: the optical imaging frontier in biology,” Nat. Methods 7(8), 603–614 (2010).
[Crossref] [PubMed]

Nat. Photonics (2)

L. V. Wang, “Multiscale photoacoustic microscopy and computed tomography,” Nat. Photonics 3(9), 503–509 (2009).
[Crossref] [PubMed]

D. Razansky, M. Distel, C. Vinegoni, R. Ma, N. Perrimon, R. W. Köster, and V. Ntziachristos, “Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo,” Nat. Photonics 3(7), 412–417 (2009).
[Crossref]

Neuroimage (1)

L.-D. Liao, M.-L. Li, H.-Y. Lai, Y.-Y. I. Shih, Y.-C. Lo, S. Tsang, P. C.-P. Chao, C.-T. Lin, F.-S. Jaw, and Y.-Y. Chen, “Imaging brain hemodynamic changes during rat forepaw electrical stimulation using functional photoacoustic microscopy,” Neuroimage 52(2), 562–570 (2010).
[Crossref] [PubMed]

Opt. Express (1)

Opt. Lett. (4)

Photoacoustics (2)

G. P. Luke, S. Y. Nam, and S. Y. Emelianov, “Optical wavelength selection for improved spectroscopic photoacoustic imaging,” Photoacoustics 1(2), 36–42 (2013).
[Crossref] [PubMed]

J. Yao and L. V. Wang, “Sensitivity of photoacoustic microscopy,” Photoacoustics 2(2), 87–101 (2014).
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Phys. Med. Biol. (7)

J. Laufer, C. Elwell, D. Delpy, and P. Beard, “In vitro measurements of absolute blood oxygen saturation using pulsed near-infrared photoacoustic spectroscopy: accuracy and resolution,” Phys. Med. Biol. 50(18), 4409–4428 (2005).
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D. Modgil and P. J. La Riviére, “Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound,” Phys. Med. Biol. 55(23), 7231–7251 (2010).
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A. P. Gibson, J. C. Hebden, and S. R. Arridge, “Recent advances in diffuse optical imaging,” Phys. Med. Biol. 50(4), R1–R43 (2005).
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J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
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World J. Surg. (1)

A. A. Tandara and T. A. Mustoe, “Oxygen in wound healing--more than a nutrient,” World J. Surg. 28(3), 294–300 (2004).
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Other (5)

P. Beard, “Biomedical photoacoustic imaging,” Interface focus, rsfs20110028 (2011).

H. S. Salehi, H. Li, P. D. Kumavor, A. Merkulov, M. Sanders, M. Brewer, and Q. Zhu, “Wavelength optimization for in vivo multispectral photoacoustic/ultrasound tomography of hemoglobin oxygenation in ovarian cancer: clinical studies,” in SPIE BiOS, (International Society for Optics and Photonics, 2015), 932303–932303–932305.

R. Hochuli, P. C. Beard, and B. Cox, “Effect of wavelength selection on the accuracy of blood oxygen saturation estimates obtained from photoacoustic images,” in Photons Plus Ultrasound: Imaging and Sensing, (2015)

S. L. Jacques and S. Prahl, Absorption Spectra for Biological Tissues (Oregon Graduate Institute 2004).

L. V. Wang and H.-i. Wu, Biomedical Optics: Principles and Imaging (John Wiley & Sons, 2012).

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Figures (10)

Fig. 1
Fig. 1 Optical absorption coefficients of oxy- (HbO_2) (red line) and deoxyhemoglobin (Hb) (blue line) [37], melanin (pink line) [7] and water (green line) [37] in the wavelength range of 450 — 1500 nm.
Fig. 2
Fig. 2 (a) Experimental (in vivo) dependence of the fluence Φ with depth when using different wavelengths: points —experimental data, dotted lines — exponential decay approximations. (b) The dependence of the increment α(λ) of fluence attenuation on the illumination wavelength.
Fig. 3
Fig. 3 The dependence of fluence Φ on depth corresponding to two wavelengths, considering the attenuation in a blood vessel (solid line), and without attenuation by the vessel (dotted line).
Fig. 4
Fig. 4 Optical parameters of the biological tissue, obtained from experimental data: (a) optical absorption coefficient of the biological tissue and (b) reduced scattering coefficient of the biological tissue.
Fig. 5
Fig. 5 Experimental dependence of rate of increase of fluence attenuation on wavelength (blue line) and the result of its approximation (red line).
Fig. 6
Fig. 6 (a) Dependence of optimal wavelengths for the determination of blood oxygen saturation on depth for a fixed value of SNRa = 30 dB, and known parameters of the biological tissue δμa = 0, δμs' = 0, and (b-d) for different values of relative error in the measurements of the optical parameters δμa and δμs' from 0.05 to 0.5.
Fig. 7
Fig. 7 Dependence of the accuracy of the determination of blood oxygen saturation on depth for different values of the relative errors of the optical parameters during diagnostics applying optimal wavelengths and a fixed value of SNRa = 30 dB.
Fig. 8
Fig. 8 Dependence of the error in the determination of blood oxygen saturation on depth for different values of the relative error of the optical parameters and for variations in SNRa from 30 to 70 dB during diagnostics applying the optimal wavelengths obtained in Section 3.3 and shown in Fig. 6.
Fig. 9
Fig. 9 Confidence intervals of wavelengths for the determination of blood oxygen saturation error at a depth of 2 mm for a fixed SNRa = 30 dB and different values of the relative errors of optical parameters from 0 to 0.3.
Fig. 10
Fig. 10 Dependence of errors in the determination of blood oxygen saturation, corresponding to blood vessel diameter for optimal wavelengths (a) λ1 = 578 nm and λ2 = 596 nm, and (b) λ1 = 658 nm and λ2 = 1069 nm.

Equations (23)

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p 0 ( z,λ )=Γ μ a ( λ )Φ( z,λ, μ a , μ s ' ),
μ a blood ( λ )= C Hb μ a Hb ( λ )+ C HbO 2 μ a HbO 2 ( λ ),
StO 2 = C HbO 2 C Hb + C HbO 2 .
{ p 1 =ΚΓ Φ 1 [ C Hb μ a Hb ( λ 1 )+ C HbO 2 μ a HbO 2 ( λ 1 ) ] p 2 =ΚΓ Φ 2 [ C Hb μ a Hb ( λ 2 )+ C HbO 2 μ a HbO 2 ( λ 2 ) ]
StO 2 = p 1 p 2 Φ 2 Φ 1 μ 2 μ 1 p 1 p 2 Φ 2 Φ 1 δμ 2 δμ 1 ,
δStO 2 =| StO 2 ( Φ 2 Φ 1 ) |Δ( Φ 2 Φ 1 )+| StO 2 p 1 |Δ p 1 +| StO 2 p 2 |Δ p 2 ,
δStO 2 = | δμ 2 μ 1 δμ 1 μ 2 | ( p 1 p 2 Φ 2 Φ 1 δμ 2 δμ 1 ) 2 ( ( Φ 2 Φ 1 1 p 2 + p 1 p 2 Φ 2 Φ 1 1 p 2 )Δp+ p 1 p 2 Δ( Φ 2 Φ 1 ) ).
Δp p( λ ) = Φ( 531nm )[ C Hb μ a Hb ( 531nm )+ C HbO 2 μ a HbO 2 ( 531nm ) ] SNR a ( 531nm, 3mm )Φ( λ )[ C Hb μ a Hb ( λ )+ C HbO 2 μ a HbO 2 ( λ ) ] ,
Φ λ ( z )= Φ 0 k( λ )exp( α( λ )z ),
α( λ )= 3 μ a ( λ )( μ a ( λ )+ μ s ' ( λ ) ) ,
k=3+5.4 R d 2exp( R d ),
R d =exp( 8 3( 1+ μ s ' / μ a ) ),
Φ 2 Φ 1 = k 2 k 1 exp( ( α 2 α 1 )z ),
Δ( Φ 2 Φ 1 )= Φ 2 Φ 1 ( Δ k 1 k 1 + Δ k 2 k 2 +z( Δ α 1 + Δα 2 ) ),
Δα= 1 2 3 μ a ( μ a + μ s ' ) [ ( 6μ a +3 μ s ' ) μ a δ μ a +3 μ a μ s ' δ μ s ' ],
Δk= 12 R d ( 5.4 R d +34exp( R d ) ) ( 3( 1+ μ s ' / μ a ) ) 3 2 μ s ' μ a [ δ μ a +δ μ s ' ],
δStO 2 = | δμ 2 μ 1 δμ 1 μ 2 | ( p 1 p 2 Φ 2 Φ 1 δμ 2 δμ 1 ) 2 ( ( Φ 2 Φ 1 1 p 2 + p 1 p 2 Φ 2 Φ 1 1 p 2 )Δp+ p 1 p 2 Φ 2 Φ 1 ( Δ k 1 k 1 + Δ k 2 k 2 +z( Δ α 1 + Δα 2 ) ) )
Φ λ ( z )= Φ 0 k( λ )exp( α( λ )z )exp( ( μ a blood (λ)α( λ ) ) d v ),
Δ( Φ 2 Φ 1 )= Φ 2 Φ 1 ( Δ k 1 k 1 + Δ k 2 k 2 +(z d v )( Δ α 1 + Δα 2 ) d v ( μ a blood ( λ 2 ) μ a blood ( λ 1 ) α 2 + α 1 ) )
δStO 2 withves = δStO 2 + δStO 2 ves ,
δStO 2 ves = | δμ 2 μ 1 δμ 1 μ 2 | ( p 1 p 2 Φ 2 Φ 1 δμ 2 δμ 1 ) 2 ( p 1 p 2 Φ 2 Φ 1 ( d v ( Δ α 1 + Δα 2 ) d v ( μ a blood ( λ 2 ) μ a blood ( λ 1 ) α 2 + α 1 ) ) )
λ 1,2 opt =arg( min λ 1,2 δStO 2 ).
λ 1,2 opt =arg( min λ 1,2 δStO 2 ves ).

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