Abstract

Changes in collagen ultrastructure between malignant and normal human thyroid tissue were investigated ex vivo using polarization second harmonic generation (SHG) microscopy. The second-order nonlinear optical susceptibility tensor component ratio and the degree of linear polarization (DOLP) of the SHG signal were measured. The ratio values are related to the collagen ultrastructure, while DOLP indicates the relative amount of coherent signal and incoherent scattering of SHG. Increase in ratio values and decrease in DOLP were observed for tumor tissue compared to normal thyroid, indicating higher ultrastructural disorder in tumor collagen.

© 2015 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy

Ahmad Golaraei, Lukas Kontenis, Richard Cisek, Danielle Tokarz, Susan J. Done, Brian C. Wilson, and Virginijus Barzda
Biomed. Opt. Express 7(10) 4054-4068 (2016)

Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy

Ahmad Golaraei, Richard Cisek, Serguei Krouglov, Roya Navab, Carolyn Niu, Shingo Sakashita, Kazuhiro Yasufuku, Ming-Sound Tsao, Brian C. Wilson, and Virginijus Barzda
Biomed. Opt. Express 5(10) 3562-3567 (2014)

Quantitative second harmonic generation microscopy for the structural characterization of capsular collagen in thyroid neoplasms

Radu Hristu, Lucian G. Eftimie, Stefan G. Stanciu, Denis E. Tranca, Bogdan Paun, Maria Sajin, and George A. Stanciu
Biomed. Opt. Express 9(8) 3923-3936 (2018)

References

  • View by:
  • |
  • |
  • |

  1. American Cancer Society, Cancer Facts & Figs. 2015 (American Cancer Society, Atlanta, GA, USA, 2015).
  2. S. Liu, R. Semenciw, A. M. Ugnat, and Y. Mao, “Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects,” Br. J. Cancer 85(9), 1335–1339 (2001).
    [Crossref] [PubMed]
  3. S. A. Hundahl, I. D. Fleming, A. M. Fremgen, and H. R. Menck, “A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995,” Cancer 83(12), 2638–2648 (1998).
    [Crossref] [PubMed]
  4. V. A. Livolsi and S. L. Asa, “The demise of follicular carcinoma of the thyroid gland,” Thyroid 4(2), 233–236 (1994).
  5. R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
    [Crossref] [PubMed]
  6. T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
    [Crossref] [PubMed]
  7. A. Golaraei, R. Cisek, S. Krouglov, R. Navab, C. Niu, S. Sakashita, K. Yasufuku, M.-S. Tsao, B. C. Wilson, and V. Barzda, “Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy,” Biomed. Opt. Express 5(10), 3562–3567 (2014).
    [Crossref] [PubMed]
  8. R. Ambekar, T.-Y. Lau, M. Walsh, R. Bhargava, and K. C. Toussaint., “Quantifying collagen structure in breast biopsies using second-harmonic generation imaging,” Biomed. Opt. Express 3(9), 2021–2035 (2012).
    [Crossref] [PubMed]
  9. K. Tilbury, C. H. Lien, S. J. Chen, and P. J. Campagnola, “Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality,” Biophys. J. 106(2), 354–365 (2014).
    [Crossref] [PubMed]
  10. A. Major, R. Cisek, D. Sandkuijl, and V. Barzda, “Femtosecond Yb:KGd(WO4)(2) laser with > 100 nJ of pulse energy,” Laser Phys. Lett. 6(4), 272–274 (2009).
    [Crossref]
  11. D. Sandkuijl, A. E. Tuer, D. Tokarz, J. E. Sipe, and V. Barzda, “Numercial second- and third-harmonic generation microscopy,” J. Opt. Soc. Am. B 30(2), 382–395 (2013).
    [Crossref]
  12. A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
    [Crossref] [PubMed]
  13. A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
    [Crossref] [PubMed]
  14. P. J. Su, W. L. Chen, Y. F. Chen, and C. Y. Dong, “Determination of collagen nanostructure from second-order susceptibility tensor analysis,” Biophys. J. 100(8), 2053–2062 (2011).
    [Crossref] [PubMed]
  15. M. Samim, S. Krouglov, and V. Barzda, “Double Stokes Mueller polarimetry of second-harmonic generation in ordered molecular structures,” J. Opt. Soc. Am. B 32(3), 451–461 (2015).
    [Crossref]
  16. A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
    [Crossref] [PubMed]
  17. T. J. Wess, “Collagen fibril form and function,” Adv. Protein Chem. 70, 341–374 (2005).
    [Crossref] [PubMed]
  18. D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
    [Crossref] [PubMed]
  19. N. Mazumder, J. Qiu, M. R. Foreman, C. M. Romero, C. W. Hu, H. R. Tsai, P. Török, and F. J. Kao, “Polarization-resolved second harmonic generation microscopy with a four-channel Stokes-polarimeter,” Opt. Express 20(13), 14090–14099 (2012).
    [Crossref] [PubMed]
  20. F. Légaré, C. L. Evans, F. Ganikhanov, and X. S. Xie, “Towards CARS endoscopy,” Opt. Express 14(10), 4427–4432 (2006).
    [Crossref] [PubMed]
  21. M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
    [Crossref] [PubMed]

2015 (1)

2014 (3)

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

A. Golaraei, R. Cisek, S. Krouglov, R. Navab, C. Niu, S. Sakashita, K. Yasufuku, M.-S. Tsao, B. C. Wilson, and V. Barzda, “Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy,” Biomed. Opt. Express 5(10), 3562–3567 (2014).
[Crossref] [PubMed]

K. Tilbury, C. H. Lien, S. J. Chen, and P. J. Campagnola, “Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality,” Biophys. J. 106(2), 354–365 (2014).
[Crossref] [PubMed]

2013 (2)

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

D. Sandkuijl, A. E. Tuer, D. Tokarz, J. E. Sipe, and V. Barzda, “Numercial second- and third-harmonic generation microscopy,” J. Opt. Soc. Am. B 30(2), 382–395 (2013).
[Crossref]

2012 (3)

2011 (1)

P. J. Su, W. L. Chen, Y. F. Chen, and C. Y. Dong, “Determination of collagen nanostructure from second-order susceptibility tensor analysis,” Biophys. J. 100(8), 2053–2062 (2011).
[Crossref] [PubMed]

2010 (1)

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

2009 (2)

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

A. Major, R. Cisek, D. Sandkuijl, and V. Barzda, “Femtosecond Yb:KGd(WO4)(2) laser with > 100 nJ of pulse energy,” Laser Phys. Lett. 6(4), 272–274 (2009).
[Crossref]

2008 (1)

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

2006 (1)

2005 (1)

T. J. Wess, “Collagen fibril form and function,” Adv. Protein Chem. 70, 341–374 (2005).
[Crossref] [PubMed]

2004 (1)

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

2001 (1)

S. Liu, R. Semenciw, A. M. Ugnat, and Y. Mao, “Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects,” Br. J. Cancer 85(9), 1335–1339 (2001).
[Crossref] [PubMed]

1998 (1)

S. A. Hundahl, I. D. Fleming, A. M. Fremgen, and H. R. Menck, “A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995,” Cancer 83(12), 2638–2648 (1998).
[Crossref] [PubMed]

1994 (1)

V. A. Livolsi and S. L. Asa, “The demise of follicular carcinoma of the thyroid gland,” Thyroid 4(2), 233–236 (1994).

Agar, N. Y. R.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Akens, M. K.

A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
[Crossref] [PubMed]

Alami, J.

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

Ambekar, R.

Asa, S. L.

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

V. A. Livolsi and S. L. Asa, “The demise of follicular carcinoma of the thyroid gland,” Thyroid 4(2), 233–236 (1994).

Bakueva, L.

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

Barzda, V.

M. Samim, S. Krouglov, and V. Barzda, “Double Stokes Mueller polarimetry of second-harmonic generation in ordered molecular structures,” J. Opt. Soc. Am. B 32(3), 451–461 (2015).
[Crossref]

A. Golaraei, R. Cisek, S. Krouglov, R. Navab, C. Niu, S. Sakashita, K. Yasufuku, M.-S. Tsao, B. C. Wilson, and V. Barzda, “Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy,” Biomed. Opt. Express 5(10), 3562–3567 (2014).
[Crossref] [PubMed]

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

D. Sandkuijl, A. E. Tuer, D. Tokarz, J. E. Sipe, and V. Barzda, “Numercial second- and third-harmonic generation microscopy,” J. Opt. Soc. Am. B 30(2), 382–395 (2013).
[Crossref]

A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
[Crossref] [PubMed]

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

A. Major, R. Cisek, D. Sandkuijl, and V. Barzda, “Femtosecond Yb:KGd(WO4)(2) laser with > 100 nJ of pulse energy,” Laser Phys. Lett. 6(4), 272–274 (2009).
[Crossref]

Benichou, E.

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

Bhargava, R.

Brevet, P.-F.

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

Camelo-Piragua, S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Campagnola, P. J.

K. Tilbury, C. H. Lien, S. J. Chen, and P. J. Campagnola, “Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality,” Biophys. J. 106(2), 354–365 (2014).
[Crossref] [PubMed]

Casey, M. B.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Chan, J. K.

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Chen, S. J.

K. Tilbury, C. H. Lien, S. J. Chen, and P. J. Campagnola, “Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality,” Biophys. J. 106(2), 354–365 (2014).
[Crossref] [PubMed]

Chen, W. L.

P. J. Su, W. L. Chen, Y. F. Chen, and C. Y. Dong, “Determination of collagen nanostructure from second-order susceptibility tensor analysis,” Biophys. J. 100(8), 2053–2062 (2011).
[Crossref] [PubMed]

Chen, Y. F.

P. J. Su, W. L. Chen, Y. F. Chen, and C. Y. Dong, “Determination of collagen nanostructure from second-order susceptibility tensor analysis,” Biophys. J. 100(8), 2053–2062 (2011).
[Crossref] [PubMed]

Cisek, R.

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

A. Golaraei, R. Cisek, S. Krouglov, R. Navab, C. Niu, S. Sakashita, K. Yasufuku, M.-S. Tsao, B. C. Wilson, and V. Barzda, “Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy,” Biomed. Opt. Express 5(10), 3562–3567 (2014).
[Crossref] [PubMed]

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

A. Major, R. Cisek, D. Sandkuijl, and V. Barzda, “Femtosecond Yb:KGd(WO4)(2) laser with > 100 nJ of pulse energy,” Laser Phys. Lett. 6(4), 272–274 (2009).
[Crossref]

DeLellis, R. A.

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Deniset-Besseau, A.

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

Dong, C. Y.

P. J. Su, W. L. Chen, Y. F. Chen, and C. Y. Dong, “Determination of collagen nanostructure from second-order susceptibility tensor analysis,” Biophys. J. 100(8), 2053–2062 (2011).
[Crossref] [PubMed]

Duboisset, J.

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

Dumont, D. J.

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

El-Ansari, O.

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

Elsheikh, T. M.

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

Erickson, L. A.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Espie, G. S.

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

Evans, C. L.

Fekl, U.

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

Fleming, I. D.

S. A. Hundahl, I. D. Fleming, A. M. Fremgen, and H. R. Menck, “A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995,” Cancer 83(12), 2638–2648 (1998).
[Crossref] [PubMed]

Foreman, M. R.

Fremgen, A. M.

S. A. Hundahl, I. D. Fleming, A. M. Fremgen, and H. R. Menck, “A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995,” Cancer 83(12), 2638–2648 (1998).
[Crossref] [PubMed]

Freudiger, C. W.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Ganikhanov, F.

Golaraei, A.

Golby, A. J.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Hache, F.

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

Harach, H. R.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Hayashi, M.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Heffess, C. S.

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

Hu, C. W.

Hundahl, S. A.

S. A. Hundahl, I. D. Fleming, A. M. Fremgen, and H. R. Menck, “A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995,” Cancer 83(12), 2638–2648 (1998).
[Crossref] [PubMed]

Ji, M.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Kakudo, K.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Kao, F. J.

Krouglov, S.

Lae, M. E.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Lam, K. Y.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Lau, D.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Lau, T.-Y.

Légaré, F.

Lien, C. H.

K. Tilbury, C. H. Lien, S. J. Chen, and P. J. Campagnola, “Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality,” Biophys. J. 106(2), 354–365 (2014).
[Crossref] [PubMed]

Ligon, K. L.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Liu, S.

S. Liu, R. Semenciw, A. M. Ugnat, and Y. Mao, “Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects,” Br. J. Cancer 85(9), 1335–1339 (2001).
[Crossref] [PubMed]

Liu, X.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

LiVolsi, V. A.

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

V. A. Livolsi and S. L. Asa, “The demise of follicular carcinoma of the thyroid gland,” Thyroid 4(2), 233–236 (1994).

Lloyd, R. V.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Lohse, C. M.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Major, A.

A. Major, R. Cisek, D. Sandkuijl, and V. Barzda, “Femtosecond Yb:KGd(WO4)(2) laser with > 100 nJ of pulse energy,” Laser Phys. Lett. 6(4), 272–274 (2009).
[Crossref]

Mao, Y.

S. Liu, R. Semenciw, A. M. Ugnat, and Y. Mao, “Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects,” Br. J. Cancer 85(9), 1335–1339 (2001).
[Crossref] [PubMed]

Mazumder, N.

Menck, H. R.

S. A. Hundahl, I. D. Fleming, A. M. Fremgen, and H. R. Menck, “A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995,” Cancer 83(12), 2638–2648 (1998).
[Crossref] [PubMed]

Navab, R.

Niu, C.

Norton, I.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Orringer, D. A.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Prent, N.

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

Qiu, J.

Ramkissoon, S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Romero, C. M.

Rosai, J.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Rowlands, J.

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

Sagher, O.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Sakashita, S.

Samim, M.

Sandkuijl, D.

D. Sandkuijl, A. E. Tuer, D. Tokarz, J. E. Sipe, and V. Barzda, “Numercial second- and third-harmonic generation microscopy,” J. Opt. Soc. Am. B 30(2), 382–395 (2013).
[Crossref]

A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
[Crossref] [PubMed]

A. Major, R. Cisek, D. Sandkuijl, and V. Barzda, “Femtosecond Yb:KGd(WO4)(2) laser with > 100 nJ of pulse energy,” Laser Phys. Lett. 6(4), 272–274 (2009).
[Crossref]

Santagata, S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Schanne-Klein, M.-C.

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

Sebo, T. J.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Semenciw, R.

S. Liu, R. Semenciw, A. M. Ugnat, and Y. Mao, “Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects,” Br. J. Cancer 85(9), 1335–1339 (2001).
[Crossref] [PubMed]

Sipe, J. E.

Sobrinho-Simoes, M.

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Spino, C.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Su, P. J.

P. J. Su, W. L. Chen, Y. F. Chen, and C. Y. Dong, “Determination of collagen nanostructure from second-order susceptibility tensor analysis,” Biophys. J. 100(8), 2053–2062 (2011).
[Crossref] [PubMed]

Tilbury, K.

K. Tilbury, C. H. Lien, S. J. Chen, and P. J. Campagnola, “Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality,” Biophys. J. 106(2), 354–365 (2014).
[Crossref] [PubMed]

Tokarz, D.

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

D. Sandkuijl, A. E. Tuer, D. Tokarz, J. E. Sipe, and V. Barzda, “Numercial second- and third-harmonic generation microscopy,” J. Opt. Soc. Am. B 30(2), 382–395 (2013).
[Crossref]

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

Török, P.

Toussaint, K. C.

Tsai, H. R.

Tsao, M.-S.

Tuer, A.

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

Tuer, A. E.

D. Sandkuijl, A. E. Tuer, D. Tokarz, J. E. Sipe, and V. Barzda, “Numercial second- and third-harmonic generation microscopy,” J. Opt. Soc. Am. B 30(2), 382–395 (2013).
[Crossref]

A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
[Crossref] [PubMed]

Ugnat, A. M.

S. Liu, R. Semenciw, A. M. Ugnat, and Y. Mao, “Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects,” Br. J. Cancer 85(9), 1335–1339 (2001).
[Crossref] [PubMed]

Walsh, M.

Wenig, B. M.

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Wess, T. J.

T. J. Wess, “Collagen fibril form and function,” Adv. Protein Chem. 70, 341–374 (2005).
[Crossref] [PubMed]

Whyne, C. M.

A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
[Crossref] [PubMed]

Wilson, B. C.

A. Golaraei, R. Cisek, S. Krouglov, R. Navab, C. Niu, S. Sakashita, K. Yasufuku, M.-S. Tsao, B. C. Wilson, and V. Barzda, “Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy,” Biomed. Opt. Express 5(10), 3562–3567 (2014).
[Crossref] [PubMed]

A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
[Crossref] [PubMed]

Xie, X. S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

F. Légaré, C. L. Evans, F. Ganikhanov, and X. S. Xie, “Towards CARS endoscopy,” Opt. Express 14(10), 4427–4432 (2006).
[Crossref] [PubMed]

Yasufuku, K.

Young, G. S.

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Adv. Protein Chem. (1)

T. J. Wess, “Collagen fibril form and function,” Adv. Protein Chem. 70, 341–374 (2005).
[Crossref] [PubMed]

Am. J. Clin. Pathol. (1)

T. M. Elsheikh, S. L. Asa, J. K. Chan, R. A. DeLellis, C. S. Heffess, V. A. LiVolsi, and B. M. Wenig, “Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma,” Am. J. Clin. Pathol. 130(5), 736–744 (2008).
[Crossref] [PubMed]

Am. J. Surg. Pathol. (1)

R. V. Lloyd, L. A. Erickson, M. B. Casey, K. Y. Lam, C. M. Lohse, S. L. Asa, J. K. Chan, R. A. DeLellis, H. R. Harach, K. Kakudo, V. A. LiVolsi, J. Rosai, T. J. Sebo, M. Sobrinho-Simoes, B. M. Wenig, and M. E. Lae, “Observer variation in the diagnosis of follicular variant of papillary thyroid carcinoma,” Am. J. Surg. Pathol. 28(10), 1336–1340 (2004).
[Crossref] [PubMed]

Biomed. Opt. Express (2)

Biophys. J. (3)

K. Tilbury, C. H. Lien, S. J. Chen, and P. J. Campagnola, “Differentiation of Col I and Col III isoforms in stromal models of ovarian cancer by analysis of second harmonic generation polarization and emission directionality,” Biophys. J. 106(2), 354–365 (2014).
[Crossref] [PubMed]

A. E. Tuer, M. K. Akens, S. Krouglov, D. Sandkuijl, B. C. Wilson, C. M. Whyne, and V. Barzda, “Hierarchical model of fibrillar collagen organization for interpreting the second-order susceptibility tensors in biological tissue,” Biophys. J. 103(10), 2093–2105 (2012).
[Crossref] [PubMed]

P. J. Su, W. L. Chen, Y. F. Chen, and C. Y. Dong, “Determination of collagen nanostructure from second-order susceptibility tensor analysis,” Biophys. J. 100(8), 2053–2062 (2011).
[Crossref] [PubMed]

Br. J. Cancer (1)

S. Liu, R. Semenciw, A. M. Ugnat, and Y. Mao, “Increasing thyroid cancer incidence in Canada, 1970-1996: time trends and age-period-cohort effects,” Br. J. Cancer 85(9), 1335–1339 (2001).
[Crossref] [PubMed]

Cancer (1)

S. A. Hundahl, I. D. Fleming, A. M. Fremgen, and H. R. Menck, “A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S., 1985–1995,” Cancer 83(12), 2638–2648 (1998).
[Crossref] [PubMed]

J. Biomed. Opt. (1)

A. Tuer, D. Tokarz, N. Prent, R. Cisek, J. Alami, D. J. Dumont, L. Bakueva, J. Rowlands, and V. Barzda, “Nonlinear multicontrast microscopy of hematoxylin-and-eosin-stained histological sections,” J. Biomed. Opt. 15(2), 026018 (2010).
[Crossref] [PubMed]

J. Opt. Soc. Am. B (2)

J. Phys. Chem. B (1)

A. Deniset-Besseau, J. Duboisset, E. Benichou, F. Hache, P.-F. Brevet, and M.-C. Schanne-Klein, “Measurement of the second-order hyperpolarizability of the collagen triple helix and determination of its physical origin,” J. Phys. Chem. B 113(40), 13437–13445 (2009).
[Crossref] [PubMed]

Laser Phys. Lett. (1)

A. Major, R. Cisek, D. Sandkuijl, and V. Barzda, “Femtosecond Yb:KGd(WO4)(2) laser with > 100 nJ of pulse energy,” Laser Phys. Lett. 6(4), 272–274 (2009).
[Crossref]

Opt. Express (2)

PLoS One (1)

D. Tokarz, R. Cisek, O. El-Ansari, G. S. Espie, U. Fekl, and V. Barzda, “Organization of astaxanthin within oil bodies of Haematococcus pluvialis studied with polarization-dependent harmonic generation microscopy,” PLoS One 9(9), e107804 (2014).
[Crossref] [PubMed]

Sci. Transl. Med. (1)

M. Ji, D. A. Orringer, C. W. Freudiger, S. Ramkissoon, X. Liu, D. Lau, A. J. Golby, I. Norton, M. Hayashi, N. Y. R. Agar, G. S. Young, C. Spino, S. Santagata, S. Camelo-Piragua, K. L. Ligon, O. Sagher, and X. S. Xie, “Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy,” Sci. Transl. Med. 5(201), 201ra119 (2013).
[Crossref] [PubMed]

Thyroid (1)

V. A. Livolsi and S. L. Asa, “The demise of follicular carcinoma of the thyroid gland,” Thyroid 4(2), 233–236 (1994).

Other (1)

American Cancer Society, Cancer Facts & Figs. 2015 (American Cancer Society, Atlanta, GA, USA, 2015).

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (2)

Fig. 1
Fig. 1 Bright field microscopy images of H&E stained (a) non-tumorous and (g, m) cancerous thyroid tissue sections, where the black boxes indicate 110 × 110 μm regions of interest imaged by PIPO SHG microscopy in panels (b, h, n). The χ(2)ZZZ’/χ(2)ZXX values were calculated for each pixel from Eq. (2), and are displayed as color-coded maps in panels (c, i, o), where blue indicates a χ(2)ZZZ’/χ(2)ZXX of 1 and red indicates 4. The frequency histograms of the χ(2)ZZZ’/χ(2)ZXX values for all the pixels are plotted in panels (d, j, p). From PIPO SHG microscopy data, DOLP values were also extracted for each pixel and are displayed as color-coded maps in panels (e, k, q), where blue indicates a DOLP of 0 and red indicates 1. Frequency histograms of the DOLP values for all the pixels are plotted in panels (f, l, r).
Fig. 2
Fig. 2 Representative PIPO SHG contour plots from individual pixels of various images: (a) normal thyroid, (b) FVPTC and (c) cPTC. The SHG intensity is represented on a false-color scale, where blue corresponds to 0 and red represents maximum intensity. Corresponding fit with Eq. (2) is in (d) and with Eq. (5) in (e, f).

Tables (1)

Tables Icon

Table 1 Average ( ± standard error) values of χ(2)ZZZ/χ(2)ZXX, the FWHM, the isotropic fraction and the DOLP for normal thyroid and tumor tissues.

Equations (5)

Equations on this page are rendered with MathJax. Learn more.

χ ZZZ (2) χ ZXX (2) = ( χ zzz (2) χ zxx (2) 3 ) cos 2 α cos 2 δ+3 ( χ zzz (2) χ zxx (2) 3 ) cos 2 α sin 2 δ+1 .
I incoh = n=0 3 I 2ω (δ=nπ/2) = ( χ ZZZ (2) χ ZXX (2) +1 ) 2 cos 2 ( θ'φ' )+ 1 4 ( ( χ ZZZ (2) χ ZXX (2) ) 2 2 χ ZZZ (2) χ ZXX (2) +5 ).
DOLP= s 1 2 + s 2 2 s 0 ,
I 2ω =A+B ( sinφ'sin2θ'+cosφ' sin 2 θ'+ χ ZZZ (2) χ ZXX (2) cosφ' cos 2 θ' ) 2 +C cos 2 ( θ'φ' ).
ψ= N N+ N ,

Metrics