Abstract

The measurement of tissue oxygenation plays an important role in the diagnosis and therapeutic assessment of a large variety of diseases. Many different methods have been developed and are currently applied in clinical practice for the measurement of tissue oxygenation. Unfortunately, each of these methods has its own limitations. In this paper we proposed the use of hyperspectral imaging as new method for the assessment of the tissue oxygenation level. To extract this information from hyperspectral images a new algorithm for mapping cutaneous tissue oxygen concentration was developed. This algorithm takes into account and solves some problems related to setting and calculation of some parameters derived from hyperspectral images. The algorithm was tested with good results on synthetic images and then validated on the fingers of a hand with different blood irrigation states. The results obtained have proved the ability of hyperspectral imaging together with the developed algorithm to map the oxy- and deoxyhemoglobin distribution on the analyzed fingers. These are only preliminary results and other studies should be done before this approach to be used in the clinical setting for the diagnosis and monitoring of various diseases.

© 2015 Optical Society of America

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References

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  1. M. D. Davis, B. K. Walsh, S. E. Sittig, and R. D. Restrepo, “AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013,” Respir. Care 58(10), 1694–1703 (2013).
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    [Crossref] [PubMed]
  7. H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref] [PubMed]
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    [Crossref]
  11. D. R. McCormack, A. J. Walsh, W. Sit, C. L. Arteaga, J. Chen, R. S. Cook, and M. C. Skala, “In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts,” Biomed. Opt. Express 5(7), 2247–2261 (2014).
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    [Crossref] [PubMed]
  13. K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
    [Crossref] [PubMed]
  14. D. Jakovels, J. Spigulis, and I. Saknite, “Multi-spectral mapping of in-vivo skin hemoglobin and melanin,” Proc. SPIE 7715, 77152Z (2010).
    [Crossref]
  15. C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
    [Crossref] [PubMed]
  16. A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49(14), N255–N257 (2004).
    [Crossref] [PubMed]
  17. J. J. More, “The Levenberg-Marquardt algorithm: Implementation and theory,” Num. Anal. Lect, Notes in Math. 630, 105–116 (1978).
    [Crossref]

2014 (4)

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

M. A. Calin, S. V. Parasca, D. Savastru, and D. Manea, “Hyperspectral Imaging in the Medical Field: Present and Future,” App. Spect. Reviews 49(6), 435–447 (2014).
[Crossref]

D. R. McCormack, A. J. Walsh, W. Sit, C. L. Arteaga, J. Chen, R. S. Cook, and M. C. Skala, “In vivo hyperspectral imaging of microvessel response to trastuzumab treatment in breast cancer xenografts,” Biomed. Opt. Express 5(7), 2247–2261 (2014).
[Crossref] [PubMed]

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

2013 (1)

M. D. Davis, B. K. Walsh, S. E. Sittig, and R. D. Restrepo, “AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013,” Respir. Care 58(10), 1694–1703 (2013).
[Crossref] [PubMed]

2011 (2)

2010 (1)

D. Jakovels, J. Spigulis, and I. Saknite, “Multi-spectral mapping of in-vivo skin hemoglobin and melanin,” Proc. SPIE 7715, 77152Z (2010).
[Crossref]

2004 (2)

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49(14), N255–N257 (2004).
[Crossref] [PubMed]

2002 (1)

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

2001 (1)

J. D. Chapman, R. F. Schneider, J. L. Urbain, and G. E. Hanks, “Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation,” Semin. Radiat. Oncol. 11(1), 47–57 (2001).
[Crossref] [PubMed]

1998 (1)

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

1996 (2)

D. W. Lübbers, “Oxygen electrodes and optodes and their application in vivo,” Adv. Exp. Med. Biol. 388, 13–34 (1996).
[Crossref] [PubMed]

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

1991 (1)

S. V. Rithalia, “Developments in transcutaneous blood gas monitoring: a review,” J. Med. Eng. Technol. 15(4-5), 143–153 (1991).
[Crossref] [PubMed]

1978 (1)

J. J. More, “The Levenberg-Marquardt algorithm: Implementation and theory,” Num. Anal. Lect, Notes in Math. 630, 105–116 (1978).
[Crossref]

Abdulrauf, B.

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

Arteaga, C. L.

Barbier, E. L.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Bouzat, P.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Buckey, J.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Calin, M. A.

M. A. Calin, S. V. Parasca, D. Savastru, and D. Manea, “Hyperspectral Imaging in the Medical Field: Present and Future,” App. Spect. Reviews 49(6), 435–447 (2014).
[Crossref]

Chapman, J. D.

J. D. Chapman, R. F. Schneider, J. L. Urbain, and G. E. Hanks, “Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation,” Semin. Radiat. Oncol. 11(1), 47–57 (2001).
[Crossref] [PubMed]

Chen, J.

Christen, T.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Comi, R.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Cook, R. S.

Cooper, C. E.

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

Cope, M.

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

Coquery, N.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Davis, M. D.

M. D. Davis, B. K. Walsh, S. E. Sittig, and R. D. Restrepo, “AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013,” Respir. Care 58(10), 1694–1703 (2013).
[Crossref] [PubMed]

Delpy, D. T.

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

Detante, O.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Elterman, K.

R. Ortega, C. J. Hansen, K. Elterman, and A. Woo, “Videos in clinical medicine. pulse oximetry,” N. Engl. J. Med. 364(16), e33 (2011).
[Crossref] [PubMed]

Elwell, C. E.

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

Fantini, S.

A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49(14), N255–N257 (2004).
[Crossref] [PubMed]

Fei, B.

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

Gould, L.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Greisen, G.

Grillon, E.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Grinberg, O.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Hanks, G. E.

J. D. Chapman, R. F. Schneider, J. L. Urbain, and G. E. Hanks, “Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation,” Semin. Radiat. Oncol. 11(1), 47–57 (2001).
[Crossref] [PubMed]

Hansen, C. J.

R. Ortega, C. J. Hansen, K. Elterman, and A. Woo, “Videos in clinical medicine. pulse oximetry,” N. Engl. J. Med. 364(16), e33 (2011).
[Crossref] [PubMed]

Hartford, A.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Hopf, H.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Hou, H.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Hug, E.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Hyttel-Sorensen, S.

Iwasaki, A.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Jakovels, D.

D. Jakovels, J. Spigulis, and I. Saknite, “Multi-spectral mapping of in-vivo skin hemoglobin and melanin,” Proc. SPIE 7715, 77152Z (2010).
[Crossref]

Khan, N.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Lemasson, B.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Lesniewski, P.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Levin, I. W.

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

Lewis, E. N.

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

Lu, G.

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

Lübbers, D. W.

D. W. Lübbers, “Oxygen electrodes and optodes and their application in vivo,” Adv. Exp. Med. Biol. 388, 13–34 (1996).
[Crossref] [PubMed]

Manea, D.

M. A. Calin, S. V. Parasca, D. Savastru, and D. Manea, “Hyperspectral Imaging in the Medical Field: Present and Future,” App. Spect. Reviews 49(6), 435–447 (2014).
[Crossref]

Mansfield, J. R.

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

Mantsch, H. H.

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

Matcher, S. J.

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

McCormack, D. R.

Meek, J. H.

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

Moisan, A.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

More, J. J.

J. J. More, “The Levenberg-Marquardt algorithm: Implementation and theory,” Num. Anal. Lect, Notes in Math. 630, 105–116 (1978).
[Crossref]

Ortega, R.

R. Ortega, C. J. Hansen, K. Elterman, and A. Woo, “Videos in clinical medicine. pulse oximetry,” N. Engl. J. Med. 364(16), e33 (2011).
[Crossref] [PubMed]

Pannetier, N.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Parasca, S. V.

M. A. Calin, S. V. Parasca, D. Savastru, and D. Manea, “Hyperspectral Imaging in the Medical Field: Present and Future,” App. Spect. Reviews 49(6), 435–447 (2014).
[Crossref]

Payen, J. F.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Payette, J. R.

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

Rémy, C.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Restrepo, R. D.

M. D. Davis, B. K. Walsh, S. E. Sittig, and R. D. Restrepo, “AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013,” Respir. Care 58(10), 1694–1703 (2013).
[Crossref] [PubMed]

Riera, J.

Rithalia, S. V.

S. V. Rithalia, “Developments in transcutaneous blood gas monitoring: a review,” J. Med. Eng. Technol. 15(4-5), 143–153 (1991).
[Crossref] [PubMed]

Saknite, I.

D. Jakovels, J. Spigulis, and I. Saknite, “Multi-spectral mapping of in-vivo skin hemoglobin and melanin,” Proc. SPIE 7715, 77152Z (2010).
[Crossref]

Salikhov, I.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Sassaroli, A.

A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49(14), N255–N257 (2004).
[Crossref] [PubMed]

Savastru, D.

M. A. Calin, S. V. Parasca, D. Savastru, and D. Manea, “Hyperspectral Imaging in the Medical Field: Present and Future,” App. Spect. Reviews 49(6), 435–447 (2014).
[Crossref]

Schaeberle, M. D.

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

Schneider, R. F.

J. D. Chapman, R. F. Schneider, J. L. Urbain, and G. E. Hanks, “Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation,” Semin. Radiat. Oncol. 11(1), 47–57 (2001).
[Crossref] [PubMed]

Sit, W.

Sittig, S. E.

M. D. Davis, B. K. Walsh, S. E. Sittig, and R. D. Restrepo, “AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013,” Respir. Care 58(10), 1694–1703 (2013).
[Crossref] [PubMed]

Skala, M. C.

Sorensen, L. C.

Sowa, M. G.

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

Spigulis, J.

D. Jakovels, J. Spigulis, and I. Saknite, “Multi-spectral mapping of in-vivo skin hemoglobin and melanin,” Proc. SPIE 7715, 77152Z (2010).
[Crossref]

Stranc, M. F.

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

Swartz, H. M.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Thomas, S.

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

Urbain, J. L.

J. D. Chapman, R. F. Schneider, J. L. Urbain, and G. E. Hanks, “Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation,” Semin. Radiat. Oncol. 11(1), 47–57 (2001).
[Crossref] [PubMed]

Walczak, T.

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

Walsh, A. J.

Walsh, B. K.

M. D. Davis, B. K. Walsh, S. E. Sittig, and R. D. Restrepo, “AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013,” Respir. Care 58(10), 1694–1703 (2013).
[Crossref] [PubMed]

Woo, A.

R. Ortega, C. J. Hansen, K. Elterman, and A. Woo, “Videos in clinical medicine. pulse oximetry,” N. Engl. J. Med. 364(16), e33 (2011).
[Crossref] [PubMed]

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C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

Zuzak, K. J.

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

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D. W. Lübbers, “Oxygen electrodes and optodes and their application in vivo,” Adv. Exp. Med. Biol. 388, 13–34 (1996).
[Crossref] [PubMed]

Anal. Chem. (1)

K. J. Zuzak, M. D. Schaeberle, E. N. Lewis, and I. W. Levin, “Visible reflectance hyperspectral imaging: characterization of a noninvasive, in vivo system for determining tissue perfusion,” Anal. Chem. 74(9), 2021–2028 (2002).
[Crossref] [PubMed]

App. Spect. Reviews (1)

M. A. Calin, S. V. Parasca, D. Savastru, and D. Manea, “Hyperspectral Imaging in the Medical Field: Present and Future,” App. Spect. Reviews 49(6), 435–447 (2014).
[Crossref]

Biomed. Opt. Express (2)

IEEE Trans. Med. Imaging (1)

J. R. Mansfield, M. G. Sowa, J. R. Payette, B. Abdulrauf, M. F. Stranc, and H. H. Mantsch, “Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis,” IEEE Trans. Med. Imaging 17(6), 1011–1018 (1998).
[Crossref] [PubMed]

J. Biomed. Opt. (1)

G. Lu and B. Fei, “Medical hyperspectral imaging: a review,” J. Biomed. Opt. 19(1), 010901 (2014).
[Crossref] [PubMed]

J. Cereb. Blood Flow Metab. (1)

T. Christen, P. Bouzat, N. Pannetier, N. Coquery, A. Moisan, B. Lemasson, S. Thomas, E. Grillon, O. Detante, C. Rémy, J. F. Payen, and E. L. Barbier, “Tissue oxygen saturation mapping with magnetic resonance imaging,” J. Cereb. Blood Flow Metab. 34(9), 1550–1557 (2014).
[Crossref] [PubMed]

J. Med. Eng. Technol. (1)

S. V. Rithalia, “Developments in transcutaneous blood gas monitoring: a review,” J. Med. Eng. Technol. 15(4-5), 143–153 (1991).
[Crossref] [PubMed]

N. Engl. J. Med. (1)

R. Ortega, C. J. Hansen, K. Elterman, and A. Woo, “Videos in clinical medicine. pulse oximetry,” N. Engl. J. Med. 364(16), e33 (2011).
[Crossref] [PubMed]

NMR Biomed. (1)

H. M. Swartz, N. Khan, J. Buckey, R. Comi, L. Gould, O. Grinberg, A. Hartford, H. Hopf, H. Hou, E. Hug, A. Iwasaki, P. Lesniewski, I. Salikhov, and T. Walczak, “Clinical applications of EPR: overview and perspectives,” NMR Biomed. 17(5), 335–351 (2004).
[Crossref] [PubMed]

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J. J. More, “The Levenberg-Marquardt algorithm: Implementation and theory,” Num. Anal. Lect, Notes in Math. 630, 105–116 (1978).
[Crossref]

Pediatr. Res. (1)

C. E. Cooper, C. E. Elwell, J. H. Meek, S. J. Matcher, J. S. Wyatt, M. Cope, and D. T. Delpy, “The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy,” Pediatr. Res. 39(1), 32–38 (1996).
[Crossref] [PubMed]

Phys. Med. Biol. (1)

A. Sassaroli and S. Fantini, “Comment on the modified Beer-Lambert law for scattering media,” Phys. Med. Biol. 49(14), N255–N257 (2004).
[Crossref] [PubMed]

Proc. SPIE (1)

D. Jakovels, J. Spigulis, and I. Saknite, “Multi-spectral mapping of in-vivo skin hemoglobin and melanin,” Proc. SPIE 7715, 77152Z (2010).
[Crossref]

Respir. Care (1)

M. D. Davis, B. K. Walsh, S. E. Sittig, and R. D. Restrepo, “AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013,” Respir. Care 58(10), 1694–1703 (2013).
[Crossref] [PubMed]

Semin. Radiat. Oncol. (1)

J. D. Chapman, R. F. Schneider, J. L. Urbain, and G. E. Hanks, “Single-photon emission computed tomography and positron-emission tomography assays for tissue oxygenation,” Semin. Radiat. Oncol. 11(1), 47–57 (2001).
[Crossref] [PubMed]

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Figures (5)

Fig. 1
Fig. 1 Experimental setup: 1. hyperspectral camera, 2. hyperspectral camera lens, 3. motorized linear positioning stage, 4. stepper controller.
Fig. 2
Fig. 2 Cutaneous tissue oxygen concentration mapping algorithm.
Fig. 3
Fig. 3 Target parameter distributions in test image: (a) oxyhemoglobin concentration, (b) deoxyhemoglobin concentration and (c) factor G.
Fig. 4
Fig. 4 Calculated parameter distributions in validated test image: (a) oxyhemoglobin concentration, (b) deoxyhemoglobin concentration and (c) factor G.
Fig. 5
Fig. 5 Calculated parameter distributions in acquired image of fingers: (a) apparent absorption at the wavelength 540 nm, (b) oxyhemoglobin concentration, (c) deoxyhemoglobin concentration, (d) factor G, (e) total effective hemoglobin concentration and (f) oxyhemoglobin saturation in the analyzed image.

Tables (1)

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Table 1 Statistics of results

Equations (11)

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A( x,y,λ )= log 10 [ I t ( x,y,λ )B( x,y,λ ) I c ( x,y,λ )B( x,y,λ ) ]
A( x,y,λ )=G( x,y )+s[ C oxy ( x,y ) ε oxy ( λ )+ C deoxy ( x,y ) ε deoxy ( λ ) ]
res= i { A r 1 s[ r 2 ε oxy ( λ i )+ r 3 ε deoxy ( λ i ) ] } 2
smax[ ε oxy ( λ )+ ε deoxy ( λ ) ]=1
s= 1 max[ ε oxy ( λ )+ ε deoxy ( λ ) ]
hemo( x,y )= C oxy ( x,y )+ C deoxy ( x,y ) sat( x,y )= C oxy ( x,y ) hemo( x,y )
A( x,y,λ )=G( x,y )+shemo( x,y ){ sat( x,y ) ε oxy ( λ )+[ 1sat( x,y ) ] ε deoxy ( λ ) }
shemo( x 0 , y 0 )= s hem o ( x 0 , y 0 )
s =s hemo( x 0 , y 0 ) hem o ( x 0 , y 0 ) =s C oxy ( x 0 , y 0 ) C oxy ( x 0 , y 0 )
C oxy ( x,y )= C oxy ( x,y ) C oxy ( x 0 , y 0 ) C oxy ( x 0 , y 0 ) C deoxy ( x,y )= C deoxy ( x,y ) C deoxy ( x 0 , y 0 ) C deoxy ( x 0 , y 0 )
G( x,y )= ( x51 ) 2 + ( y51 ) 2 G max 5000

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