Abstract

In this paper, we take the transmission 3 × 3 linear polarization Mueller matrix images of the unstained thin slices of human cervical and thyroid cancer tissues, and analyze their multispectral behavior using the Mueller matrix transformation (MMT) parameters. The experimental results show that for both cervical and thyroid cancerous tissues, the characteristic features of multispectral transmitted MMT parameters can be used to distinguish the normal and abnormal areas. Moreover, Monte Carlo simulations based on the sphere-cylinder birefringence model (SCBM) provide additional information of the relations between the characteristic spectral features of the MMT parameters and the microstructures of the tissues. Comparisons between the experimental and simulated data confirm that the contrast mechanism of the transmission MMT imaging for cancer detection is the breaking down of birefringent normal tissues for cervical cancer, or the formation of birefringent surrounding structures accompanying the inflammatory reaction for thyroid cancer. It is also testified that, the characteristic spectral features of polarization imaging techniques can provide more detailed microstructural information of tissues for diagnosis applications.

© 2015 Optical Society of America

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    [Crossref] [PubMed]

2015 (4)

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

S. Alali and A. Vitkin, “Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment,” J. Biomed. Opt. 20(6), 061104 (2015).
[Crossref] [PubMed]

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
[Crossref] [PubMed]

C. He, J. Chang, Y. Wang, R. Liao, H. He, N. Zeng, and H. Ma, “Linear polarization optimized Stokes polarimeter based on four-quadrant detector,” Appl. Opt. 54(14), 4458–4463 (2015).
[Crossref] [PubMed]

2014 (7)

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

J. Jagtap, S. Chandel, N. Das, J. Soni, S. Chatterjee, A. Pradhan, and N. Ghosh, “Quantitative Mueller matrix fluorescence spectroscopy for precancer detection,” Opt. Lett. 39(2), 243–246 (2014).
[Crossref] [PubMed]

N. T. Clancy, S. Arya, J. Qi, D. Stoyanov, G. B. Hanna, and D. S. Elson, “Polarised stereo endoscope and narrowband detection for minimal access surgery,” Biomed. Opt. Express 5(12), 4108–4117 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

2013 (7)

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

J. Qi, M. Ye, M. Singh, N. T. Clancy, and D. S. Elson, “Narrow band 3 × 3 Mueller polarimetric endoscopy,” Biomed. Opt. Express 4(11), 2433–2449 (2013).
[Crossref] [PubMed]

J. Soni, H. Purwar, H. Lakhotia, S. Chandel, C. Banerjee, U. Kumar, and N. Ghosh, “Quantitative fluorescence and elastic scattering tissue polarimetry using an Eigenvalue calibrated spectroscopic Mueller matrix system,” Opt. Express 21(13), 15475–15489 (2013).
[Crossref] [PubMed]

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

N. Ortega-Quijano, F. Fanjul-Vélez, I. Salas-García, and J. L. Arce-Diego, “Polarized light Monte Carlo analysis of birefringence-induced depolarization in biological tissues,” Proc. SPIE 8803, 88030T (2013).
[Crossref]

Y. Guo, N. Zeng, H. He, T. Yun, E. Du, R. Liao, Y. He, and H. Ma, “A study on forward scattering Mueller matrix decomposition in anisotropic medium,” Opt. Express 21(15), 18361–18370 (2013).
[Crossref] [PubMed]

2012 (3)

S. Alali, M. Ahmad, A. Kim, N. Vurgun, M. F. G. Wood, and I. A. Vitkin, “Quantitative correlation between light depolarization and transport albedo of various porcine tissues,” J. Biomed. Opt. 17(4), 045004 (2012).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, Y. Guo, R. Liao, Y. He, and H. Ma, “Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media,” J. Biomed. Opt. 17(12), 126016 (2012).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

2011 (2)

2010 (1)

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

2009 (2)

2007 (1)

2002 (1)

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[Crossref] [PubMed]

2001 (1)

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

2000 (2)

S. L. Jacques, J. R. Roman, and K. Lee, “Imaging superficial tissues with polarized light,” Lasers Surg. Med. 26(2), 119–129 (2000).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

1996 (1)

1991 (1)

R. R. Anderson, “Polarized light examination and photography of the skin,” Arch. Dermatol. 127(7), 1000–1005 (1991).
[Crossref] [PubMed]

Ahmad, M.

S. Alali, M. Ahmad, A. Kim, N. Vurgun, M. F. G. Wood, and I. A. Vitkin, “Quantitative correlation between light depolarization and transport albedo of various porcine tissues,” J. Biomed. Opt. 17(4), 045004 (2012).
[Crossref] [PubMed]

Alali, S.

S. Alali and A. Vitkin, “Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment,” J. Biomed. Opt. 20(6), 061104 (2015).
[Crossref] [PubMed]

S. Alali, M. Ahmad, A. Kim, N. Vurgun, M. F. G. Wood, and I. A. Vitkin, “Quantitative correlation between light depolarization and transport albedo of various porcine tissues,” J. Biomed. Opt. 17(4), 045004 (2012).
[Crossref] [PubMed]

Anderson, R. R.

R. R. Anderson, “Polarized light examination and photography of the skin,” Arch. Dermatol. 127(7), 1000–1005 (1991).
[Crossref] [PubMed]

Antonelli, M. R.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

A. Pierangelo, A. Benali, M. R. Antonelli, T. Novikova, P. Validire, B. Gayet, and A. De Martino, “Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging,” Opt. Express 19(2), 1582–1593 (2011).
[Crossref] [PubMed]

Arce-Diego, J. L.

N. Ortega-Quijano, F. Fanjul-Vélez, I. Salas-García, and J. L. Arce-Diego, “Polarized light Monte Carlo analysis of birefringence-induced depolarization in biological tissues,” Proc. SPIE 8803, 88030T (2013).
[Crossref]

Arendt, J. T.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Arya, S.

Backman, V.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Badizadegan, K.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Banerjee, C.

Benali, A.

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

A. Pierangelo, A. Benali, M. R. Antonelli, T. Novikova, P. Validire, B. Gayet, and A. De Martino, “Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging,” Opt. Express 19(2), 1582–1593 (2011).
[Crossref] [PubMed]

Chandel, S.

Chang, J.

Chatterjee, S.

Chen, D.

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
[Crossref] [PubMed]

Chen, Z.

Chipman, R. A.

Chung, J.

Chuttani, R.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Clancy, N. T.

Cohen, H.

Crawford, J. M.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Das, N.

Dasari, R. R.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

De Martino, A.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

A. Pierangelo, A. Benali, M. R. Antonelli, T. Novikova, P. Validire, B. Gayet, and A. De Martino, “Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging,” Opt. Express 19(2), 1582–1593 (2011).
[Crossref] [PubMed]

Doronin, A.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Du, E.

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

Y. Guo, N. Zeng, H. He, T. Yun, E. Du, R. Liao, Y. He, and H. Ma, “A study on forward scattering Mueller matrix decomposition in anisotropic medium,” Opt. Express 21(15), 18361–18370 (2013).
[Crossref] [PubMed]

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

E. Du, H. He, N. Zeng, Y. Guo, R. Liao, Y. He, and H. Ma, “Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media,” J. Biomed. Opt. 17(12), 126016 (2012).
[Crossref] [PubMed]

Eccles, M.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Elson, D. S.

Fallet, C.

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

Fanjul-Vélez, F.

N. Ortega-Quijano, F. Fanjul-Vélez, I. Salas-García, and J. L. Arce-Diego, “Polarized light Monte Carlo analysis of birefringence-induced depolarization in biological tissues,” Proc. SPIE 8803, 88030T (2013).
[Crossref]

Feld, M. S.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Fitzmaurice, M.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Gayet, B.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

A. Pierangelo, A. Benali, M. R. Antonelli, T. Novikova, P. Validire, B. Gayet, and A. De Martino, “Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging,” Opt. Express 19(2), 1582–1593 (2011).
[Crossref] [PubMed]

Georgakoudi, I.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

Ghosh, N.

Goldsmith, J. D.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Guo, L.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Guo, Y.

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

Y. Guo, N. Zeng, H. He, T. Yun, E. Du, R. Liao, Y. He, and H. Ma, “A study on forward scattering Mueller matrix decomposition in anisotropic medium,” Opt. Express 21(15), 18361–18370 (2013).
[Crossref] [PubMed]

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

E. Du, H. He, N. Zeng, Y. Guo, R. Liao, Y. He, and H. Ma, “Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media,” J. Biomed. Opt. 17(12), 126016 (2012).
[Crossref] [PubMed]

Gurjar, R.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Gurjar, R. S.

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

Hammer-Wilson, M. J.

Hanlon, E. B.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Hanna, G. B.

He, C.

He, H.

C. He, J. Chang, Y. Wang, R. Liao, H. He, N. Zeng, and H. Ma, “Linear polarization optimized Stokes polarimeter based on four-quadrant detector,” Appl. Opt. 54(14), 4458–4463 (2015).
[Crossref] [PubMed]

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

Y. Guo, N. Zeng, H. He, T. Yun, E. Du, R. Liao, Y. He, and H. Ma, “A study on forward scattering Mueller matrix decomposition in anisotropic medium,” Opt. Express 21(15), 18361–18370 (2013).
[Crossref] [PubMed]

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

E. Du, H. He, N. Zeng, Y. Guo, R. Liao, Y. He, and H. Ma, “Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media,” J. Biomed. Opt. 17(12), 126016 (2012).
[Crossref] [PubMed]

He, Y.

Ibrahim, B. H.

Itani, S.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Itzkan, I.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Jacques, S.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Jacques, S. L.

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[Crossref] [PubMed]

S. L. Jacques, J. R. Roman, and K. Lee, “Imaging superficial tissues with polarized light,” Lasers Surg. Med. 26(2), 119–129 (2000).
[Crossref] [PubMed]

Jagtap, J.

Jiang, X.

Jung, W.

Kabani, S.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Kim, A.

S. Alali, M. Ahmad, A. Kim, N. Vurgun, M. F. G. Wood, and I. A. Vitkin, “Quantitative correlation between light depolarization and transport albedo of various porcine tissues,” J. Biomed. Opt. 17(4), 045004 (2012).
[Crossref] [PubMed]

Kline, E.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Kumar, U.

Kunnen, B.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Lakhotia, H.

Lee, K.

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[Crossref] [PubMed]

S. L. Jacques, J. R. Roman, and K. Lee, “Imaging superficial tissues with polarized light,” Lasers Surg. Med. 26(2), 119–129 (2000).
[Crossref] [PubMed]

Levin, H. S.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Leyden, J.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Li, D.

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

T. Yun, N. Zeng, W. Li, D. Li, X. Jiang, and H. Ma, “Monte Carlo simulation of polarized photon scattering in anisotropic media,” Opt. Express 17(19), 16590–16602 (2009).
[Crossref] [PubMed]

Li, W.

Liao, R.

C. He, J. Chang, Y. Wang, R. Liao, H. He, N. Zeng, and H. Ma, “Linear polarization optimized Stokes polarimeter based on four-quadrant detector,” Appl. Opt. 54(14), 4458–4463 (2015).
[Crossref] [PubMed]

Y. Guo, N. Zeng, H. He, T. Yun, E. Du, R. Liao, Y. He, and H. Ma, “A study on forward scattering Mueller matrix decomposition in anisotropic medium,” Opt. Express 21(15), 18361–18370 (2013).
[Crossref] [PubMed]

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

E. Du, H. He, N. Zeng, Y. Guo, R. Liao, Y. He, and H. Ma, “Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media,” J. Biomed. Opt. 17(12), 126016 (2012).
[Crossref] [PubMed]

Lim, L. G.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Liu, Q.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Liu, S.

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

Lu, S. Y.

Ma, H.

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
[Crossref] [PubMed]

C. He, J. Chang, Y. Wang, R. Liao, H. He, N. Zeng, and H. Ma, “Linear polarization optimized Stokes polarimeter based on four-quadrant detector,” Appl. Opt. 54(14), 4458–4463 (2015).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

Y. Guo, N. Zeng, H. He, T. Yun, E. Du, R. Liao, Y. He, and H. Ma, “A study on forward scattering Mueller matrix decomposition in anisotropic medium,” Opt. Express 21(15), 18361–18370 (2013).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, Y. Guo, R. Liao, Y. He, and H. Ma, “Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media,” J. Biomed. Opt. 17(12), 126016 (2012).
[Crossref] [PubMed]

T. Yun, N. Zeng, W. Li, D. Li, X. Jiang, and H. Ma, “Monte Carlo simulation of polarized photon scattering in anisotropic media,” Opt. Express 17(19), 16590–16602 (2009).
[Crossref] [PubMed]

Macdonald, C.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Manhas, S.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

Martino, A. D.

McGilligan, J. A.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Meglinski, I.

B. Kunnen, C. Macdonald, A. Doronin, S. Jacques, M. Eccles, and I. Meglinski, “Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media,” J. Biophotonics 8(4), 317–323 (2015).
[Crossref] [PubMed]

Modell, M. D.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Müller, M. G.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Nazac, A.

Novikova, T.

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

A. Pierangelo, A. Benali, M. R. Antonelli, T. Novikova, P. Validire, B. Gayet, and A. De Martino, “Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging,” Opt. Express 19(2), 1582–1593 (2011).
[Crossref] [PubMed]

Ortega-Quijano, N.

N. Ortega-Quijano, F. Fanjul-Vélez, I. Salas-García, and J. L. Arce-Diego, “Polarized light Monte Carlo analysis of birefringence-induced depolarization in biological tissues,” Proc. SPIE 8803, 88030T (2013).
[Crossref]

Ozden, N.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Peng, C.

Perelman, L. T.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

R. S. Gurjar, V. Backman, L. T. Perelman, I. Georgakoudi, K. Badizadegan, I. Itzkan, R. R. Dasari, and M. S. Feld, “Imaging human epithelial properties with polarized light-scattering spectroscopy,” Nat. Med. 7(11), 1245–1248 (2001).
[Crossref] [PubMed]

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Pierangelo, A.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

A. Pierangelo, A. Benali, M. R. Antonelli, T. Novikova, P. Validire, B. Gayet, and A. De Martino, “Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging,” Opt. Express 19(2), 1582–1593 (2011).
[Crossref] [PubMed]

Pleskow, D. K.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Pradhan, A.

Purwar, H.

Qi, J.

Qiu, L.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Ramella-Roman, J. C.

S. L. Jacques, J. C. Ramella-Roman, and K. Lee, “Imaging skin pathology with polarized light,” J. Biomed. Opt. 7(3), 329–340 (2002).
[Crossref] [PubMed]

Roman, J. R.

S. L. Jacques, J. R. Roman, and K. Lee, “Imaging superficial tissues with polarized light,” Lasers Surg. Med. 26(2), 119–129 (2000).
[Crossref] [PubMed]

Sacks, A.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Salas-García, I.

N. Ortega-Quijano, F. Fanjul-Vélez, I. Salas-García, and J. L. Arce-Diego, “Polarized light Monte Carlo analysis of birefringence-induced depolarization in biological tissues,” Proc. SPIE 8803, 88030T (2013).
[Crossref]

Seiler, M.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Shabbir, A.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Shapshay, S.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Shukla, P.

Singh, M.

Soni, J.

Srivastava, S.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Stoyanov, D.

Sun, M.

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

Totobenazara, J. L.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

Valdez, T.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Validire, P.

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, J. L. Totobenazara, M. R. Antonelli, T. Novikova, B. Gayet, A. De Martino, and P. Validire, “Multispectral Mueller polarimetric imaging detecting residual cancer and cancer regression after neoadjuvant treatment for colorectal carcinomas,” J. Biomed. Opt. 18(4), 046014 (2013).
[Crossref] [PubMed]

A. Pierangelo, A. Nazac, A. Benali, P. Validire, H. Cohen, T. Novikova, B. H. Ibrahim, S. Manhas, C. Fallet, M. R. Antonelli, and A. D. Martino, “Polarimetric imaging of uterine cervix: a case study,” Opt. Express 21(12), 14120–14130 (2013).
[Crossref] [PubMed]

A. Pierangelo, S. Manhas, A. Benali, C. Fallet, M. R. Antonelli, T. Novikova, B. Gayet, P. Validire, and A. De Martino, “Ex vivo photometric and polarimetric multilayer characterization of human healthy colon by multispectral Mueller imaging,” J. Biomed. Opt. 17(6), 066009 (2012).
[Crossref] [PubMed]

A. Pierangelo, A. Benali, M. R. Antonelli, T. Novikova, P. Validire, B. Gayet, and A. De Martino, “Ex-vivo characterization of human colon cancer by Mueller polarimetric imaging,” Opt. Express 19(2), 1582–1593 (2011).
[Crossref] [PubMed]

Van Dam, J.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Vitkin, A.

S. Alali and A. Vitkin, “Polarized light imaging in biomedicine: emerging Mueller matrix methodologies for bulk tissue assessment,” J. Biomed. Opt. 20(6), 061104 (2015).
[Crossref] [PubMed]

Vitkin, E.

L. Qiu, D. K. Pleskow, R. Chuttani, E. Vitkin, J. Leyden, N. Ozden, S. Itani, L. Guo, A. Sacks, J. D. Goldsmith, M. D. Modell, E. B. Hanlon, I. Itzkan, and L. T. Perelman, “Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus,” Nat. Med. 16(5), 603–606 (2010).
[Crossref] [PubMed]

Vitkin, I. A.

S. Alali, M. Ahmad, A. Kim, N. Vurgun, M. F. G. Wood, and I. A. Vitkin, “Quantitative correlation between light depolarization and transport albedo of various porcine tissues,” J. Biomed. Opt. 17(4), 045004 (2012).
[Crossref] [PubMed]

N. Ghosh and I. A. Vitkin, “Tissue polarimetry: concepts, challenges, applications, and outlook,” J. Biomed. Opt. 16(11), 110801 (2011).
[Crossref] [PubMed]

Vurgun, N.

S. Alali, M. Ahmad, A. Kim, N. Vurgun, M. F. G. Wood, and I. A. Vitkin, “Quantitative correlation between light depolarization and transport albedo of various porcine tissues,” J. Biomed. Opt. 17(4), 045004 (2012).
[Crossref] [PubMed]

Wallace, M. B.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Wang, W.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Wang, Y.

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
[Crossref] [PubMed]

C. He, J. Chang, Y. Wang, R. Liao, H. He, N. Zeng, and H. Ma, “Linear polarization optimized Stokes polarimeter based on four-quadrant detector,” Appl. Opt. 54(14), 4458–4463 (2015).
[Crossref] [PubMed]

Wilder-Smith, P.

Wood, M. F. G.

S. Alali, M. Ahmad, A. Kim, N. Vurgun, M. F. G. Wood, and I. A. Vitkin, “Quantitative correlation between light depolarization and transport albedo of various porcine tissues,” J. Biomed. Opt. 17(4), 045004 (2012).
[Crossref] [PubMed]

Wu, J.

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

Yan, J. S.

W. Wang, L. G. Lim, S. Srivastava, J. S. Yan, A. Shabbir, and Q. Liu, “Roles of linear and circular polarization properties and effect of wavelength choice on differentiation between ex vivo normal and cancerous gastric samples,” J. Biomed. Opt. 19(4), 046020 (2014).
[Crossref] [PubMed]

Ye, M.

Yun, T.

Zeng, N.

C. He, J. Chang, Y. Wang, R. Liao, H. He, N. Zeng, and H. Ma, “Linear polarization optimized Stokes polarimeter based on four-quadrant detector,” Appl. Opt. 54(14), 4458–4463 (2015).
[Crossref] [PubMed]

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
[Crossref] [PubMed]

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

E. Du, H. He, N. Zeng, M. Sun, Y. Guo, J. Wu, S. Liu, and H. Ma, “Mueller matrix polarimetry for differentiating characteristic features of cancerous tissues,” J. Biomed. Opt. 19(7), 076013 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, C. Peng, Y. He, and H. Ma, “Probing microstructural information of anisotropic scattering media using rotation-independent polarization parameters,” Appl. Opt. 53(14), 2949–2955 (2014).
[Crossref] [PubMed]

M. Sun, H. He, N. Zeng, E. Du, Y. Guo, S. Liu, J. Wu, Y. He, and H. Ma, “Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters,” Biomed. Opt. Express 5(12), 4223–4234 (2014).
[Crossref] [PubMed]

Y. Guo, N. Zeng, H. He, T. Yun, E. Du, R. Liao, Y. He, and H. Ma, “A study on forward scattering Mueller matrix decomposition in anisotropic medium,” Opt. Express 21(15), 18361–18370 (2013).
[Crossref] [PubMed]

H. He, N. Zeng, E. Du, Y. Guo, D. Li, R. Liao, and H. Ma, “A possible quantitative Mueller matrix transformation technique for anisotropic scattering media,” Photonics Lasers Med. 2(2), 129–137 (2013).
[Crossref]

E. Du, H. He, N. Zeng, Y. Guo, R. Liao, Y. He, and H. Ma, “Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media,” J. Biomed. Opt. 17(12), 126016 (2012).
[Crossref] [PubMed]

T. Yun, N. Zeng, W. Li, D. Li, X. Jiang, and H. Ma, “Monte Carlo simulation of polarized photon scattering in anisotropic media,” Opt. Express 17(19), 16590–16602 (2009).
[Crossref] [PubMed]

Zhang, Q.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Zonios, G.

V. Backman, M. B. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Müller, Q. Zhang, G. Zonios, E. Kline, J. A. McGilligan, S. Shapshay, T. Valdez, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. Itzkan, J. Van Dam, and M. S. Feld, “Detection of preinvasive cancer cells,” Nature 406(6791), 35–36 (2000).
[Crossref] [PubMed]

Appl. Opt. (3)

Arch. Dermatol. (1)

R. R. Anderson, “Polarized light examination and photography of the skin,” Arch. Dermatol. 127(7), 1000–1005 (1991).
[Crossref] [PubMed]

Biomed. Opt. Express (3)

J. Biomed. Opt. (11)

H. He, M. Sun, N. Zeng, E. Du, S. Liu, Y. Guo, J. Wu, Y. He, and H. Ma, “Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging,” J. Biomed. Opt. 19(10), 106007 (2014).
[Crossref] [PubMed]

Y. Wang, Y. Guo, N. Zeng, D. Chen, H. He, and H. Ma, “Study on the validity of 3 × 3 Mueller matrix decomposition,” J. Biomed. Opt. 20(6), 065003 (2015).
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Figures (9)

Fig. 1
Fig. 1 Schematic of the forward MMT experimental setup. L1, L2: lens; VariSpec: liquid crystal transmission filter; R: quarter wave plate; P1, P2: polarizer; The light source (halogen lamp) is about 40 cm away from the sample. The diameter of the illumination area is about 1.5 cm. The field of view and magnification of the imaging system are 0.5 cm × 0.5 cm and 0.4, respectively.
Fig. 2
Fig. 2 (a), (b) Photograph of the 28 μm thick slices of unstained human cervix and papillary thyroid carcinoma tissues, the red squares indicate the imaging regions and the black squares indicate the testing regions used for Fig. 3, (c), (d) microscopic images of the corresponding H-E stained slices of cancerous and healthy cervical tissues, (e), (f) microscopic images of the corresponding H-E stained slices of cancerous and healthy thyroid tissues.
Fig. 3
Fig. 3 Pseudo-color images of the MMPD and MMT parameters of (a) cervical carcinoma tissue and (b) papillary thyroid carcinoma tissue. The wavelength of incident light is 630 nm. The cancerous and healthy regions of the tissues are distinguished by the white and black dotted lines.
Fig. 4
Fig. 4 Pseudo-color images of the MMT parameter A (upper row) and parameter b (lower row) for the unstained human cervix carcinoma tissue slice with the incident wavelengths of 500 nm, 590 nm, 680 nm. The imaging region is indicated by the red square in Fig. 2(a). The white and black dotted lines represent the border of the cancerous tissue and the healthy tissue approximately, and the squares represent the random sample areas used for quantitative analysis.
Fig. 5
Fig. 5 Values of parameter A (a) and b (b) of the normal and cancerous cervical tissues at different wavelengths.
Fig. 6
Fig. 6 Pseudo-color images of the MMT parameter A (upper row) and parameter b (lower row) for the unstained slice of human papillary thyroid carcinoma tissue with the incident wavelengths of 500 nm, 590 nm, 680 nm. The imaging region is indicated by the red square in Fig. 2(b). The white and black dotted lines represent the border of the cancerous tissue and the healthy tissue approximately, and the squares represent the random sample areas used for quantitative analysis.
Fig. 7
Fig. 7 Values of parameter A (a) and b (b) of the normal and human papillary thyroid carcinoma tissues at different wavelengths.
Fig. 8
Fig. 8 Multispectral Monte Carlo simulation results of the parameters A (a) and b (b) using the sphere-birefringence model with 0.001, 0.002 and 0.003 birefringence Δn values.
Fig. 9
Fig. 9 Monte Carlo simulation results of: (a), (b) Values of parameter A and b of the sphere-cylinder scattering model. The diameters and the scattering coefficients of the cylindrical scatterers are set to be 1.5 μm and 200 cm−1, 0.2 μm and 200 cm−1, 0.2 μm and 400 cm−1, respectively. The parameters of the spherical scatterers remain the same as Fig. 8. (c), (d) Values of parameter A and b of the sphere-birefringence model. The diameter of the small spherical scatterers is set to be 0.2 μm, 0.5 μm, and 0.8 μm. The other parameters are the same as Fig. 8. (e), (f) Values of parameter A and b of the sphere-birefringence model. The ratio between the scattering coefficients of the small and large spheres is changed from 50:150 to 100:100 and 150:50.

Equations (1)

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A= 2bt b 2 + t 2 [0,1] b= m22+m33 2   t= (m22m33) 2 + (m23+m32) 2 2

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