Abstract

We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm2 field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations within the oral cavity. Image quality of 2-dimensional image slices through the data can be greatly enhanced by averaging over the orthogonal dimension to reduce speckle. Initial in vivo imaging results reveal a wide-field view of features such as epithelial thickness and continuity of the basement membrane that may be useful in clinic for chair-side management of oral lesions.

© 2015 Optical Society of America

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2015 (2)

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

Y. Yoon, W. H. Jang, P. Xiao, B. Kim, T. Wang, Q. Li, J. Y. Lee, E. Chung, and K. H. Kim, “In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe,” Biomed. Opt. Express 6(2), 524–535 (2015).
[Crossref] [PubMed]

2014 (4)

2013 (5)

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

E. Z. Zhang, W.-Y. Oh, M. L. Villiger, L. Chen, B. E. Bouma, and B. J. Vakoc, “Numerical compensation of system polarization mode dispersion in polarization-sensitive optical coherence tomography,” Opt. Express 21(1), 1163–1180 (2013).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

2012 (5)

B. Davoudi, A. Lindenmaier, B. A. Standish, G. Allo, K. Bizheva, and A. Vitkin, “Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography,” Biomed. Opt. Express 3(5), 826–839 (2012).
[Crossref] [PubMed]

C.-K. Lee, T.-T. Chi, C.-T. Wu, M.-T. Tsai, C.-P. Chiang, and C.-C. Yang, “Diagnosis of oral precancer with optical coherence tomography,” Biomed. Opt. Express 3(7), 1632–1646 (2012).
[Crossref] [PubMed]

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

2010 (3)

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

P. Wilder-Smith, J. Holtzman, J. Epstein, and A. Le, “Optical diagnostics in the oral cavity: an overview,” Oral Dis. 16(8), 717–728 (2010).
[Crossref] [PubMed]

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

2009 (5)

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

D. C. Adler, C. Zhou, T.-H. Tsai, J. Schmitt, Q. Huang, H. Mashimo, and J. G. Fujimoto, “Three-dimensional endomicroscopy of the human colon using optical coherence tomography,” Opt. Express 17(2), 784–796 (2009).
[Crossref] [PubMed]

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 47(8), 622–626 (2009).
[Crossref] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108(3), 425–429 (2009).
[Crossref] [PubMed]

2008 (2)

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

2006 (2)

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

2005 (2)

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

2004 (1)

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

2003 (1)

2000 (1)

C. Scully and S. Porter, “ABC of oral health. Oral cancer,” BMJ 321(7253), 97–100 (2000).
[Crossref] [PubMed]

1999 (1)

J. M. Zakrzewska, “Fortnightly review: Oral cancer,” BMJ 318(7190), 1051–1054 (1999).
[Crossref] [PubMed]

1997 (1)

Adegun, O. K.

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Adler, D. C.

Ahsen, O. O.

Al-Delayme, R.

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

Allo, G.

Anderson, D. W.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Aretz, H. T.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Armstrong, W. B.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Bader, D. L.

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Berean, K. W.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Betz, C. S.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Beydoun, H.

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

Bizheva, K.

Bouma, B. E.

E. Z. Zhang, W.-Y. Oh, M. L. Villiger, L. Chen, B. E. Bouma, and B. J. Vakoc, “Numerical compensation of system polarization mode dispersion in polarization-sensitive optical coherence tomography,” Opt. Express 21(1), 1163–1180 (2013).
[Crossref] [PubMed]

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Brenner, M.

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

Cable, A.

Cahill, L.

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

Cense, B.

Chang, C.-C.

Chen, H.-M.

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

Chen, L.

Chen, Z.

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

Chi, T.-T.

Chiang, C.-P.

C.-K. Lee, T.-T. Chi, C.-T. Wu, M.-T. Tsai, C.-P. Chiang, and C.-C. Yang, “Diagnosis of oral precancer with optical coherence tomography,” Biomed. Opt. Express 3(7), 1632–1646 (2012).
[Crossref] [PubMed]

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

Choi, W.

Choi, W. J.

Chong, C.

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 47(8), 622–626 (2009).
[Crossref] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108(3), 425–429 (2009).
[Crossref] [PubMed]

Chung, E.

Conn, B.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Crumley, R. L.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Davoudi, B.

de Boer, J.

de Boer, J. F.

Duan, C.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Durham, J. S.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

El Maaytah, M.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Epstein, J.

P. Wilder-Smith, J. Holtzman, J. Epstein, and A. Le, “Optical diagnostics in the oral cavity: an overview,” Oral Dis. 16(8), 717–728 (2010).
[Crossref] [PubMed]

Fortune, F.

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Fu, L.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Fujimoto, J. G.

Gong, Z.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Gu, M.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Guo, S.

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Hagi-Pavli, E.

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Halpern, E. F.

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Hamdoon, Z.

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Higgins, L. M.

L. M. Higgins and M. C. Pierce, “Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions,” J. Biomed. Opt. 19(8), 086004 (2014).
[Crossref] [PubMed]

Holtzman, J.

P. Wilder-Smith, J. Holtzman, J. Epstein, and A. Le, “Optical diagnostics in the oral cavity: an overview,” Oral Dis. 16(8), 717–728 (2010).
[Crossref] [PubMed]

Hopper, C.

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Hornegger, J.

Houser, S.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Huang, Q.

Iftima, N.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Ihrler, S.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

Jackson, K.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

Jackson, R. P.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Jang, I.-K.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Jang, W. H.

Jay, A.

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Jayaraman, V.

Jerjes, W.

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Jia, H.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Jillella, P. A.

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

Jung, W.-G.

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

Kim, B.

Kim, K. H.

Kraft, M.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Kraus, M. F.

Kurabayashi, T.

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 47(8), 622–626 (2009).
[Crossref] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108(3), 425–429 (2009).
[Crossref] [PubMed]

Lam, S.

A. M. D. Lee, H. Pahlevaninezhad, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “Fiber-optic polarization diversity detection for rotary probe optical coherence tomography,” Opt. Lett. 39(12), 3638–3641 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Lane, P.

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

A. M. D. Lee, H. Pahlevaninezhad, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “Fiber-optic polarization diversity detection for rotary probe optical coherence tomography,” Opt. Lett. 39(12), 3638–3641 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Lauwers, G. Y.

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

Le, A.

P. Wilder-Smith, J. Holtzman, J. Epstein, and A. Le, “Optical diagnostics in the oral cavity: an overview,” Oral Dis. 16(8), 717–728 (2010).
[Crossref] [PubMed]

Lee, A. M. D.

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

A. M. D. Lee, H. Pahlevaninezhad, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “Fiber-optic polarization diversity detection for rotary probe optical coherence tomography,” Opt. Lett. 39(12), 3638–3641 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Lee, B.

Lee, C.-K.

C.-K. Lee, T.-T. Chi, C.-T. Wu, M.-T. Tsai, C.-P. Chiang, and C.-C. Yang, “Diagnosis of oral precancer with optical coherence tomography,” Biomed. Opt. Express 3(7), 1632–1646 (2012).
[Crossref] [PubMed]

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

Lee, H.-C.

Z. Wang, H.-C. Lee, O. O. Ahsen, B. Lee, W. Choi, B. Potsaid, J. Liu, V. Jayaraman, A. Cable, M. F. Kraus, K. Liang, J. Hornegger, and J. G. Fujimoto, “Depth-encoded all-fiber swept source polarization sensitive OCT,” Biomed. Opt. Express 5(9), 2931–2949 (2014).
[Crossref] [PubMed]

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

Lee, J. Y.

Lee, K.

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

Leunig, A.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

Li, Q.

Liang, K.

Lindenmaier, A.

Liu, J.

Lu, C.-W.

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

Ma, J. S.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

MacAulay, C.

A. M. D. Lee, H. Pahlevaninezhad, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “Fiber-optic polarization diversity detection for rotary probe optical coherence tomography,” Opt. Lett. 39(12), 3638–3641 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

MacAulay, C. E.

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

MacNeill, B.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Mahmood, U.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Mashimo, H.

McKenzie, G.

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

McWilliams, A.

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Messadi, D.

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

Milner, T. E.

Mino-Kenudson, M.

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

Moselewski, F.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Nelson, J. S.

Ng, S.

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Nishioka, N. S.

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

Oh, W.-Y.

Ohtani, K.

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Osann, K.

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

Ozawa, N.

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 47(8), 622–626 (2009).
[Crossref] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108(3), 425–429 (2009).
[Crossref] [PubMed]

Pahlevaninezhad, H.

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

A. M. D. Lee, H. Pahlevaninezhad, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “Fiber-optic polarization diversity detection for rotary probe optical coherence tomography,” Opt. Lett. 39(12), 3638–3641 (2014).
[Crossref] [PubMed]

Park, B.

Patel, P. M.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

Pierce, M.

Pierce, M. C.

L. M. Higgins and M. C. Pierce, “Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions,” J. Biomed. Opt. 19(8), 086004 (2014).
[Crossref] [PubMed]

Piper, K.

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Poh, C.

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

Poh, C. F.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Porter, S.

C. Scully and S. Porter, “ABC of oral health. Oral cancer,” BMJ 321(7253), 97–100 (2000).
[Crossref] [PubMed]

Potsaid, B.

Prestin, S.

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Priddy, R. W.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Radhi, H.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Ridgway, J. M.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Rosin, M. P.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Rothschild, S. I.

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Samuelson, S.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Sandison, A.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Schmitt, J.

Scully, C.

C. Scully and S. Porter, “ABC of oral health. Oral cancer,” BMJ 321(7253), 97–100 (2000).
[Crossref] [PubMed]

Shaipanich, T.

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Shibuya, T.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

Shibuya, T. Y.

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Shimozato, K.

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108(3), 425–429 (2009).
[Crossref] [PubMed]

Shishkov, M.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Standish, B. A.

Stepp, H.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

Su, J.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Sumi, Y.

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 47(8), 622–626 (2009).
[Crossref] [PubMed]

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108(3), 425–429 (2009).
[Crossref] [PubMed]

Susarla, M.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

Suter, M. J.

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

Takano, M.

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Tearney, G. J.

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Tomlins, P. H.

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Tsai, M.-T.

C.-K. Lee, T.-T. Chi, C.-T. Wu, M.-T. Tsai, C.-P. Chiang, and C.-C. Yang, “Diagnosis of oral precancer with optical coherence tomography,” Biomed. Opt. Express 3(7), 1632–1646 (2012).
[Crossref] [PubMed]

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

Tsai, T.-H.

Tseng, O. L.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Upile, T.

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Vakoc, B. J.

E. Z. Zhang, W.-Y. Oh, M. L. Villiger, L. Chen, B. E. Bouma, and B. J. Vakoc, “Numerical compensation of system polarization mode dispersion in polarization-sensitive optical coherence tomography,” Opt. Express 21(1), 1163–1180 (2013).
[Crossref] [PubMed]

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

van Gemert, M. J. C.

Villiger, M. L.

Vitkin, A.

Volgger, V.

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

Vourvachis, M.

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

Wang, D.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Wang, R. K.

Wang, T.

Wang, X.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Wang, Y.-M.

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

Wang, Z.

Wilder-Smith, P.

P. Wilder-Smith, J. Holtzman, J. Epstein, and A. Le, “Optical diagnostics in the oral cavity: an overview,” Oral Dis. 16(8), 717–728 (2010).
[Crossref] [PubMed]

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

Williams, P. M.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Wong, B. J.

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

Wong, B. J. F.

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Wu, C.-T.

Xiao, P.

Xie, H.

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

Yang, C. C.

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

M.-T. Tsai, H.-C. Lee, C.-K. Lee, C.-H. Yu, H.-M. Chen, C.-P. Chiang, C.-C. Chang, Y.-M. Wang, and C. C. Yang, “Effective indicators for diagnosis of oral cancer using optical coherence tomography,” Opt. Express 16(20), 15847–15862 (2008).
[Crossref] [PubMed]

Yang, C.-C.

C.-K. Lee, T.-T. Chi, C.-T. Wu, M.-T. Tsai, C.-P. Chiang, and C.-C. Yang, “Diagnosis of oral precancer with optical coherence tomography,” Biomed. Opt. Express 3(7), 1632–1646 (2012).
[Crossref] [PubMed]

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

Yang, V. X. D.

A. M. D. Lee, H. Pahlevaninezhad, V. X. D. Yang, S. Lam, C. MacAulay, and P. Lane, “Fiber-optic polarization diversity detection for rotary probe optical coherence tomography,” Opt. Lett. 39(12), 3638–3641 (2014).
[Crossref] [PubMed]

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Yoon, Y.

Yu, C.-H.

Zakrzewska, J. M.

J. M. Zakrzewska, “Fortnightly review: Oral cancer,” BMJ 318(7190), 1051–1054 (1999).
[Crossref] [PubMed]

Zhang, E. Z.

Zhang, J.

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

Zhang, L.

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Zhou, C.

Arch. Otolaryngol. Head Neck Surg. (1)

J. M. Ridgway, W. B. Armstrong, S. Guo, U. Mahmood, J. Su, R. P. Jackson, T. Shibuya, R. L. Crumley, M. Gu, Z. Chen, and B. J. Wong, “In vivo optical coherence tomography of the human oral cavity and oropharynx,” Arch. Otolaryngol. Head Neck Surg. 132(10), 1074–1081 (2006).
[Crossref] [PubMed]

Biomed. Opt. Express (5)

BMJ (2)

J. M. Zakrzewska, “Fortnightly review: Oral cancer,” BMJ 318(7190), 1051–1054 (1999).
[Crossref] [PubMed]

C. Scully and S. Porter, “ABC of oral health. Oral cancer,” BMJ 321(7253), 97–100 (2000).
[Crossref] [PubMed]

Br. J. Oral Maxillofac. Surg. (2)

W. Jerjes, T. Upile, B. Conn, Z. Hamdoon, C. S. Betz, G. McKenzie, H. Radhi, M. Vourvachis, M. El Maaytah, A. Sandison, A. Jay, and C. Hopper, “In vitro examination of suspicious oral lesions using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 48(1), 18–25 (2010).
[Crossref] [PubMed]

N. Ozawa, Y. Sumi, C. Chong, and T. Kurabayashi, “Evaluation of oral vascular anomalies using optical coherence tomography,” Br. J. Oral Maxillofac. Surg. 47(8), 622–626 (2009).
[Crossref] [PubMed]

Circulation (1)

I.-K. Jang, G. J. Tearney, B. MacNeill, M. Takano, F. Moselewski, N. Iftima, M. Shishkov, S. Houser, H. T. Aretz, E. F. Halpern, and B. E. Bouma, “In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography,” Circulation 111(12), 1551–1555 (2005).
[Crossref] [PubMed]

Clin. Cancer Res. (1)

C. F. Poh, L. Zhang, D. W. Anderson, J. S. Durham, P. M. Williams, R. W. Priddy, K. W. Berean, S. Ng, O. L. Tseng, C. MacAulay, and M. P. Rosin, “Fluorescence Visualization Detection of Field Alterations in Tumor Margins of Oral Cancer Patients,” Clin. Cancer Res. 12(22), 6716–6722 (2006).
[Crossref] [PubMed]

Gastrointest. Endosc. (1)

M. J. Suter, P. A. Jillella, B. J. Vakoc, E. F. Halpern, M. Mino-Kenudson, G. Y. Lauwers, B. E. Bouma, N. S. Nishioka, and G. J. Tearney, “Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine,” Gastrointest. Endosc. 71(2), 346–353 (2010).
[Crossref] [PubMed]

Head Neck (2)

V. Volgger, H. Stepp, S. Ihrler, M. Kraft, A. Leunig, P. M. Patel, M. Susarla, K. Jackson, and C. S. Betz, “Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract,” Head Neck 35(11), 1558–1566 (2013).
[Crossref] [PubMed]

S. Prestin, S. I. Rothschild, C. S. Betz, and M. Kraft, “Measurement of epithelial thickness within the oral cavity using optical coherence tomography,” Head Neck 34(12), 1777–1781 (2012).
[Crossref] [PubMed]

Head Neck Oncol. (1)

Z. Hamdoon, W. Jerjes, R. Al-Delayme, G. McKenzie, A. Jay, and C. Hopper, “Structural validation of oral mucosal tissue using optical coherence tomography,” Head Neck Oncol. 4(1), 29 (2012).
[Crossref] [PubMed]

J. Biomed. Opt. (5)

M.-T. Tsai, H.-M. Chen, Y.-M. Wang, C.-C. Yang, C.-P. Chiang, C.-K. Lee, and H.-C. Lee, “Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography,” J. Biomed. Opt. 14, 044028 (2009).

D. Wang, L. Fu, X. Wang, Z. Gong, S. Samuelson, C. Duan, H. Jia, J. S. Ma, and H. Xie, “Endoscopic swept-source optical coherence tomography based on a two-axis microelectromechanical system mirror,” J. Biomed. Opt. 18(8), 086005 (2013).
[Crossref] [PubMed]

L. M. Higgins and M. C. Pierce, “Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions,” J. Biomed. Opt. 19(8), 086004 (2014).
[Crossref] [PubMed]

M.-T. Tsai, C.-P. Chiang, H.-C. Lee, C.-W. Lu, Y.-M. Wang, C.-K. Lee, and C. C. Yang, “Delineation of an oral cancer lesion with swept-source optical coherence tomography,” J. Biomed. Opt. 13, 044012 (2008).

A. M. D. Lee, K. Ohtani, C. Macaulay, A. McWilliams, T. Shaipanich, V. X. D. Yang, S. Lam, and P. Lane, “In vivo lung microvasculature visualized in three dimensions using fiber-optic color Doppler optical coherence tomography,” J. Biomed. Opt. 18(5), 050501 (2013).
[Crossref] [PubMed]

Laryngoscope (1)

B. J. F. Wong, R. P. Jackson, S. Guo, J. M. Ridgway, U. Mahmood, J. Su, T. Y. Shibuya, R. L. Crumley, M. Gu, W. B. Armstrong, and Z. Chen, “In Vivo Optical Coherence Tomography of the Human Larynx: Normative and Benign Pathology in 82 Patients,” Laryngoscope 115(11), 1904–1911 (2005).
[Crossref] [PubMed]

Lasers Med. Sci. (1)

O. K. Adegun, P. H. Tomlins, E. Hagi-Pavli, G. McKenzie, K. Piper, D. L. Bader, and F. Fortune, “Quantitative analysis of optical coherence tomography and histopathology images of normal and dysplastic oral mucosal tissues,” Lasers Med. Sci. 27(4), 795–804 (2012).
[Crossref] [PubMed]

Lasers Surg. Med. (2)

P. Wilder-Smith, W.-G. Jung, M. Brenner, K. Osann, H. Beydoun, D. Messadi, and Z. Chen, “In vivo optical coherence tomography for the diagnosis of oral malignancy,” Lasers Surg. Med. 35(4), 269–275 (2004).
[Crossref] [PubMed]

P. Wilder-Smith, K. Lee, S. Guo, J. Zhang, K. Osann, Z. Chen, and D. Messadi, “In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: Preliminary studies in 50 patients,” Lasers Surg. Med. 41(5), 353–357 (2009).
[Crossref] [PubMed]

Opt. Express (4)

Opt. Lett. (2)

Oral Dis. (1)

P. Wilder-Smith, J. Holtzman, J. Epstein, and A. Le, “Optical diagnostics in the oral cavity: an overview,” Oral Dis. 16(8), 717–728 (2010).
[Crossref] [PubMed]

Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. (1)

N. Ozawa, Y. Sumi, K. Shimozato, C. Chong, and T. Kurabayashi, “In vivo imaging of human labial glands using advanced optical coherence tomography,” Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 108(3), 425–429 (2009).
[Crossref] [PubMed]

Photodiagn. Photodyn. Ther. (1)

Z. Hamdoon, W. Jerjes, T. Upile, G. McKenzie, A. Jay, and C. Hopper, “Optical coherence tomography in the assessment of suspicious oral lesions: An immediate ex vivo study,” Photodiagn. Photodyn. Ther. 10(1), 17–27 (2013).
[Crossref] [PubMed]

Proc. SPIE (1)

L. Cahill, A. M. D. Lee, H. Pahlevaninezhad, S. Ng, C. E. MacAulay, C. Poh, and P. Lane, “Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components,” Proc. SPIE 9304, 930413 (2015).

Other (2)

J. Pindborg, P. Reichart, C. Smith, and I. van der Wall, Histological Typing of Cancer and Precancer of the Oral Mucosa (Springer Berlin Heidelberg, 1997).

S. I. J. Ferlay, M. Ervik, R. Dikshit, S. Eser, C. Mathers, M. Rebelo, D. M. Parkin, D. Forman, and F. Bray, “GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 ” (International Agency for Research on Cancer, 2013), retrieved http://globocan.iarc.fr , accessed on Jan. 5, 2015.

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Figures (6)

Fig. 1
Fig. 1

Schematic diagram of endoscopic PSOCT system. SS = swept-source laser, PC = polarization controller, CIRC = circulator, C = collimator, POL = polarizer, RM = reference mirror, AIM = aiming laser, WDM = wavelength division multiplexer, FORJ = fiber optic rotary joint, RPC = rotary pullback catheter, PMFC = polarization maintaining fiber coupler, PBS = polarization beamsplitter, BD = balanced detector. Dashed (red) lines indicate PM fiber; all others are SM fiber. The SM and PM patch cables indicated within the dotted box can be removed to yield a standard (polarization-independent) OCT imaging system.

Fig. 2
Fig. 2

Fiber optic OCT catheter holders for oral imaging. Catheter sheath (red) bonded to (a) a modified saliva ejector, or (b) a modified disposable dental mirror. Insets show cross-sections of the imaging portion of the catheter holders showing the 0.9mm OD catheter within the 1.5mm OD sheath. Relative to the orientation in the insets, the catheters are pressed downwards against the tissue. (c,d) Photographs of the catheter holders in use.

Fig. 3
Fig. 3

Wide-field OCT data presentation of a 27 mm pullback (pullback speed = 2 mm/s) of normal lateral tongue from a 59-year old male subject taken with the modified dental mirror catheter sheath holder. The pullback direction is from left to right. (a) Rotary pullback catheter coordinate system. (b) Polar and (c) Cartesian presentations of a single imaging frame indicated by dashed (red) line in the en face projection shown in (d). (e,g) Azimuthal presentation along solid (blue) line in (d). (f) Zoomed azimuthal view of dashed (green) box in (e). The aspect ratio in (e) and (f) is 1:1 while (g) has been stretched vertically to show more detail. White bars in the images are 1 mm in length. The θ axes in the images have been scaled as if the image has been projected onto the outer diameter of the 1.5 mm catheter sheath. There is no averaging for these images, w = 1.

Fig. 4
Fig. 4

OCT image of clinically normal lateral tongue from a 58-year old female subject acquired with the modified dental mirror catheter sheath holder. The pullback direction is from left to right. (a) En face projection displaying 33mm x 4.7mm FOV. (b,d) Azimuthal views along solid (blue) line shown in (a). (c,e) Cartesian views along dotted (red) line shown in (a). (b,c) have no averaging, w = 1 (d,e) have been averaged with a triangular kernel of width 5, w = 5. The white bars in the images are 1 mm in length. The theta scale bar in (a) has been scaled as if image is projected onto outer diameter of catheter sheath.

Fig. 5
Fig. 5

OCT image of clinically visible lesion from same subject as Fig. 4 contralateral to the previous imaging location. The pullback direction is from left to right. (a) En face projection displaying 33mm x 4.7mm FOV. L indicates a dark region. (b) Clinical photo of lesion and approximate imaging location (c) azimuthal view along solid (blue) line shown in (a). (d) Cartesian view along dotted (red) line shown in (a). The white bars in the images are 1 mm in length. The images are averaged with a triangular kernel of width 5, w = 5.

Fig. 6
Fig. 6

OCT imaging of a submucosal fibrosis lesion on the buccal mucosa of a 48-year old male patient. The pullback direction is from left to right corresponding to posterior to anterior orientation. (b) Clinical photo of the lesion being imaged with the modified saliva ejector catheter holder. Structural OCT (a) en face projection and (c) azimuthal slice. The clinically visible lesion is indicated between the solid (pink) vertical lines. Slices along the dotted (red) and dashed (green) lines are shown in Cartesian images in (d) and (e) respectively. (f, g, h) Retardation images corresponding to the structural images (c,d,e) respectively. The images are averaged with a triangular kernel of width 5, w = 5. The white bars in the images are 1 mm in length.

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