Abstract

An unmet need exists in high-speed and highly-sensitive intraoperative assessment of breast cancer margin during conservation surgical procedures. Here, we demonstrate a multispectral photoacoustic tomography system for breast tumor margin assessment using fat and hemoglobin as contrasts. This system provides ~3 mm tissue depth and ~125 μm axial resolution. The results agreed with the histological findings. A high sensitivity in margin assessment was accomplished, which opens a compelling way to intraoperative margin assessment.

© 2015 Optical Society of America

Full Article  |  PDF Article
OSA Recommended Articles
Evaluation of breast tumor margins in vivo with intraoperative photoacoustic imaging

Lei Xi, Stephen R. Grobmyer, Lei Wu, Ruimin Chen, Guangyin Zhou, Luke G. Gutwein, Jingjing Sun, Wenjun Liao, Qifa Zhou, Huikai Xie, and Huabei Jiang
Opt. Express 20(8) 8726-8731 (2012)

Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

Wes M. Allen, Lixin Chin, Philip Wijesinghe, Rodney W. Kirk, Bruce Latham, David D. Sampson, Christobel M. Saunders, and Brendan F. Kennedy
Biomed. Opt. Express 7(10) 4139-4153 (2016)

Performance metrics of an optical spectral imaging system for intra-operative assessment of breast tumor margins

Torre M. Bydlon, Stephanie A. Kennedy, Lisa M. Richards, J. Quincy Brown, Bing Yu, Marlee K. Junker, Jennifer Gallagher, Joseph Geradts, Lee G. Wilke, and Nimmi Ramanujam
Opt. Express 18(8) 8058-8076 (2010)

References

  • View by:
  • |
  • |
  • |

  1. B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
    [Crossref] [PubMed]
  2. U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
    [Crossref] [PubMed]
  3. R. Arriagada, M. G. Lê, F. Rochard, G. Contesso, and Institut Gustave-Roussy Breast Cancer Group, “Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data,” J. Clin. Oncol. 14(5), 1558–1564 (1996).
    [PubMed]
  4. J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
    [Crossref] [PubMed]
  5. D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
    [Crossref] [PubMed]
  6. G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
    [Crossref] [PubMed]
  7. M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
    [Crossref] [PubMed]
  8. N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
    [Crossref] [PubMed]
  9. P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
    [Crossref] [PubMed]
  10. M. C. Smitt, K. Nowels, R. W. Carlson, and S. S. Jeffrey, “Predictors of reexcision findings and recurrence after breast conservation,” Int. J. Radiat. Oncol. Biol. Phys. 57(4), 979–985 (2003).
    [Crossref] [PubMed]
  11. D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
    [Crossref] [PubMed]
  12. J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
    [Crossref] [PubMed]
  13. L. Jacobs, “Positive margins: The challenge continues for breast surgeons,” Ann. Surg. Oncol. 15(5), 1271–1272 (2008).
    [Crossref] [PubMed]
  14. J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
    [Crossref] [PubMed]
  15. G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg. 71(1), 22–27 (2005).
    [PubMed]
  16. F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
    [Crossref] [PubMed]
  17. T. L. Huston, R. Pigalarga, M. P. Osborne, and E. Tousimis, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery,” Am. J. Surg. 192(4), 509–512 (2006).
    [Crossref] [PubMed]
  18. O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
    [Crossref] [PubMed]
  19. J. C. Cendán, D. Coco, and E. M. Copeland, “Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins,” J. Am. Coll. Surg. 201(2), 194–198 (2005).
    [Crossref] [PubMed]
  20. F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
    [Crossref] [PubMed]
  21. A. J. Creager, J. A. Shaw, P. R. Young, and K. R. Geisinger, “Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: A community hospital experience,” Arch. Pathol. Lab. Med. 126(7), 846–848 (2002).
    [PubMed]
  22. M. Thill, “MarginProbe: Intraoperative margin assessment during breast conserving surgery by using radiofrequency spectroscopy,” Expert Rev. Med. Devices 10(3), 301–315 (2013).
    [Crossref] [PubMed]
  23. M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
    [Crossref] [PubMed]
  24. H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
    [Crossref] [PubMed]
  25. J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
    [PubMed]
  26. T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
    [Crossref] [PubMed]
  27. S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
    [Crossref] [PubMed]
  28. F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
    [Crossref] [PubMed]
  29. M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
    [Crossref] [PubMed]
  30. M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
    [Crossref] [PubMed]
  31. A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
    [Crossref] [PubMed]
  32. D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
    [Crossref] [PubMed]
  33. M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
    [Crossref] [PubMed]
  34. G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
    [Crossref] [PubMed]
  35. M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
    [Crossref] [PubMed]
  36. R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
    [Crossref] [PubMed]
  37. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
    [Crossref] [PubMed]
  38. H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
    [Crossref] [PubMed]
  39. J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
    [Crossref] [PubMed]
  40. J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
    [Crossref] [PubMed]
  41. Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
    [Crossref] [PubMed]
  42. D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
    [Crossref]
  43. K. E. Wilson, S. V. Bachawal, L. Tian, and J. K. Willmann, “Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model,” Theranostics 4(11), 1062–1071 (2014).
    [Crossref] [PubMed]
  44. S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
    [Crossref] [PubMed]
  45. S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
    [Crossref] [PubMed]
  46. J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
    [Crossref] [PubMed]
  47. B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
    [Crossref] [PubMed]
  48. H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
    [Crossref] [PubMed]
  49. R. Li, M. N. Slipchenko, P. Wang, and J. X. Cheng, “Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat,” J. Biomed. Opt. 18(4), 040502 (2013).
    [Crossref] [PubMed]
  50. J. R. Rajian, R. Li, P. Wang, and J. X. Cheng, “Vibrational photoacoustic tomography: Chemical imaging beyond the ballistic regime,” J. Phys. Chem. Lett. 4(19), 3211–3215 (2013).
    [Crossref] [PubMed]
  51. B. Wang, A. Karpiouk, D. Yeager, J. Amirian, S. Litovsky, R. Smalling, and S. Emelianov, “Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood,” Opt. Lett. 37(7), 1244–1246 (2012).
    [Crossref] [PubMed]
  52. P. Wang, J. R. Rajian, and J. X. Cheng, “Spectroscopic imaging of deep tissue through photoacoustic detection of molecular vibration,” J. Phys. Chem. Lett. 4(13), 2177–2185 (2013).
    [Crossref] [PubMed]
  53. J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, “A graphical user-friendly interface for mcr-als: A new tool for multivariate curve resolution in matlab,” Chemometr. Intell. Lab 76(1), 101–110 (2005).
    [Crossref]
  54. L. W. Jerry Workman, Practical Guide to Interpretive Near-Infrared Spectroscopy (CRC press, 2007).
  55. P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
    [Crossref] [PubMed]

2014 (3)

M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
[Crossref] [PubMed]

K. E. Wilson, S. V. Bachawal, L. Tian, and J. K. Willmann, “Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model,” Theranostics 4(11), 1062–1071 (2014).
[Crossref] [PubMed]

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

2013 (8)

R. Li, M. N. Slipchenko, P. Wang, and J. X. Cheng, “Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat,” J. Biomed. Opt. 18(4), 040502 (2013).
[Crossref] [PubMed]

J. R. Rajian, R. Li, P. Wang, and J. X. Cheng, “Vibrational photoacoustic tomography: Chemical imaging beyond the ballistic regime,” J. Phys. Chem. Lett. 4(19), 3211–3215 (2013).
[Crossref] [PubMed]

P. Wang, J. R. Rajian, and J. X. Cheng, “Spectroscopic imaging of deep tissue through photoacoustic detection of molecular vibration,” J. Phys. Chem. Lett. 4(13), 2177–2185 (2013).
[Crossref] [PubMed]

M. Thill, “MarginProbe: Intraoperative margin assessment during breast conserving surgery by using radiofrequency spectroscopy,” Expert Rev. Med. Devices 10(3), 301–315 (2013).
[Crossref] [PubMed]

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

2012 (2)

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

B. Wang, A. Karpiouk, D. Yeager, J. Amirian, S. Litovsky, R. Smalling, and S. Emelianov, “Intravascular photoacoustic imaging of lipid in atherosclerotic plaques in the presence of luminal blood,” Opt. Lett. 37(7), 1244–1246 (2012).
[Crossref] [PubMed]

2011 (4)

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

2010 (4)

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

2009 (8)

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
[Crossref] [PubMed]

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

2008 (2)

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

L. Jacobs, “Positive margins: The challenge continues for breast surgeons,” Ann. Surg. Oncol. 15(5), 1271–1272 (2008).
[Crossref] [PubMed]

2007 (3)

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

2006 (4)

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

T. L. Huston, R. Pigalarga, M. P. Osborne, and E. Tousimis, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery,” Am. J. Surg. 192(4), 509–512 (2006).
[Crossref] [PubMed]

2005 (4)

J. C. Cendán, D. Coco, and E. M. Copeland, “Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins,” J. Am. Coll. Surg. 201(2), 194–198 (2005).
[Crossref] [PubMed]

G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg. 71(1), 22–27 (2005).
[PubMed]

S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
[Crossref] [PubMed]

J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, “A graphical user-friendly interface for mcr-als: A new tool for multivariate curve resolution in matlab,” Chemometr. Intell. Lab 76(1), 101–110 (2005).
[Crossref]

2004 (1)

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

2003 (2)

M. C. Smitt, K. Nowels, R. W. Carlson, and S. S. Jeffrey, “Predictors of reexcision findings and recurrence after breast conservation,” Int. J. Radiat. Oncol. Biol. Phys. 57(4), 979–985 (2003).
[Crossref] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

2002 (3)

A. J. Creager, J. A. Shaw, P. R. Young, and K. R. Geisinger, “Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: A community hospital experience,” Arch. Pathol. Lab. Med. 126(7), 846–848 (2002).
[PubMed]

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

2000 (3)

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

1999 (1)

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

1996 (1)

R. Arriagada, M. G. Lê, F. Rochard, G. Contesso, and Institut Gustave-Roussy Breast Cancer Group, “Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data,” J. Clin. Oncol. 14(5), 1558–1564 (1996).
[PubMed]

1971 (1)

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Aft, R. L.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Aguilar, M.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Ahmed, S.

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

Al Mushawah, F.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Alvarez, M. C.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Ambrose, B. J.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Ames, F. C.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Amirian, J.

Anderson, S.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Appleton, C. M.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Arriagada, R.

R. Arriagada, M. G. Lê, F. Rochard, G. Contesso, and Institut Gustave-Roussy Breast Cancer Group, “Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data,” J. Clin. Oncol. 14(5), 1558–1564 (1996).
[PubMed]

Arridge, S. R.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Arts, H. J. G.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Atkins, J.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Aziz, D.

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

Babiera, G. V.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Bach, M.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Bachawal, S. V.

K. E. Wilson, S. V. Bachawal, L. Tian, and J. K. Willmann, “Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model,” Theranostics 4(11), 1062–1071 (2014).
[Crossref] [PubMed]

Balch, G. C.

G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg. 71(1), 22–27 (2005).
[PubMed]

Ballone, E.

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

Barry, W.

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Barry, W. T.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Bart, J.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Bartelink, H.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Baumann, K.

M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
[Crossref] [PubMed]

Beard, P.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

Bellafiore, F. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Bendavid, C.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Blanchot, J.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Blanco, C.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Bleiweiss, I.

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

Blohmer, J. U.

M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
[Crossref] [PubMed]

Boppart, S. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Boulos, F. I.

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

Brecht, H. P.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Brown, J. Q.

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Bryant, J.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Buchholz, T. A.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Busch, D. R.

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Butler, J.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Bydlon, T.

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Bydlon, T. M.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Cabioglu, N.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Carlson, R. W.

M. C. Smitt, K. Nowels, R. W. Carlson, and S. S. Jeffrey, “Predictors of reexcision findings and recurrence after breast conservation,” Int. J. Radiat. Oncol. Biol. Phys. 57(4), 979–985 (2003).
[Crossref] [PubMed]

Cascinelli, N.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Cèfaro, G. A.

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

Cendán, J. C.

J. C. Cendán, D. Coco, and E. M. Copeland, “Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins,” J. Am. Coll. Surg. 201(2), 194–198 (2005).
[Crossref] [PubMed]

Cerussi, A.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Chai, N.

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Chance, B.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Chaney, E. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Chen, L.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Chen, Z.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Cheng, J. X.

P. Wang, J. R. Rajian, and J. X. Cheng, “Spectroscopic imaging of deep tissue through photoacoustic detection of molecular vibration,” J. Phys. Chem. Lett. 4(13), 2177–2185 (2013).
[Crossref] [PubMed]

R. Li, M. N. Slipchenko, P. Wang, and J. X. Cheng, “Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat,” J. Biomed. Opt. 18(4), 040502 (2013).
[Crossref] [PubMed]

J. R. Rajian, R. Li, P. Wang, and J. X. Cheng, “Vibrational photoacoustic tomography: Chemical imaging beyond the ballistic regime,” J. Phys. Chem. Lett. 4(19), 3211–3215 (2013).
[Crossref] [PubMed]

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Cheng, J.-X.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Choe, R.

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Cianchetti, E.

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

Coco, D.

J. C. Cendán, D. Coco, and E. M. Copeland, “Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins,” J. Am. Coll. Surg. 201(2), 194–198 (2005).
[Crossref] [PubMed]

Conjusteau, A.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Contesso, G.

R. Arriagada, M. G. Lê, F. Rochard, G. Contesso, and Institut Gustave-Roussy Breast Cancer Group, “Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data,” J. Clin. Oncol. 14(5), 1558–1564 (1996).
[PubMed]

Copeland, E. M.

J. C. Cendán, D. Coco, and E. M. Copeland, “Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins,” J. Am. Coll. Surg. 201(2), 194–198 (2005).
[Crossref] [PubMed]

Corlu, A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Coué, O.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Crane, L. M. A.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Creager, A. J.

A. J. Creager, J. A. Shaw, P. R. Young, and K. R. Geisinger, “Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: A community hospital experience,” Arch. Pathol. Lab. Med. 126(7), 846–848 (2002).
[PubMed]

Crowe, J. P.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Culver, J. P.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Cyr, A. E.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Czerniecki, B. J.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

D’Halluin, F.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Dai, J.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Dasari, R. R.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Davidoff, F.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

de Jong, J. S.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

de Juan, A.

J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, “A graphical user-friendly interface for mcr-als: A new tool for multivariate curve resolution in matlab,” Chemometr. Intell. Lab 76(1), 101–110 (2005).
[Crossref]

de Matos Granja, N.

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

Delpy, D.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

Demichele, A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Desperito, E.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Deutsch, M.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Di Nicola, M.

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

Dillon, M. F.

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

Ding, H.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Ding, Q.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Dittmer, C.

M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
[Crossref] [PubMed]

Do, S. H.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Dou, W.

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Doyle, T. E.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Dubsky, P.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Durduran, T.

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Eberlein, T. J.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Ellefson, C. L.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Elwell, C.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

Emelianov, S.

Ermilov, S. A.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Espinoza, J.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Factor, R. E.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Feig, B. W.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Feld, M. S.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Fentiman, I. S.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Fisher, B.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Fisher, E. R.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Fitzal, F.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Fitzmaurice, M.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Fleming, F. J.

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

Flexman, M. L.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Folkman, J.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Foucher, F.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Fraker, D. L.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Friedrichs, K.

M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
[Crossref] [PubMed]

Fronheiser, M.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Gajdos, C.

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

Galanzha, E. I.

J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
[Crossref] [PubMed]

Gallagher, J.

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Gao, F.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Gardecki, J. A.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Gargallo, R.

J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, “A graphical user-friendly interface for mcr-als: A new tool for multivariate curve resolution in matlab,” Chemometr. Intell. Lab 76(1), 101–110 (2005).
[Crossref]

Geisinger, K. R.

A. J. Creager, J. A. Shaw, P. R. Young, and K. R. Geisinger, “Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: A community hospital experience,” Arch. Pathol. Lab. Med. 126(7), 846–848 (2002).
[PubMed]

Genovesi, D.

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

Geradts, J.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Gillanders, W. E.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Glass, J.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Gnant, M.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Goldberg, A.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Goodrich, J. B.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Greco, M.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Grobmyer, S. R.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Gunther, J. E.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Haka, A. S.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Harlaar, N. J.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Hart, V. P.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Helle, P. A.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Henshaw, E.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Hershman, D. L.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Hiatt, H. H.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Hicks, D.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Hielscher, A. H.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Hill, A. D.

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

Hill, A. D. K.

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

Hirsch, C.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Holloway, C. M.

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

Holmes, D. R.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Hovanessian-Larsen, L. J.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Hu, S.

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Hui, J.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Hunt, K. K.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Huston, T. L.

T. L. Huston, R. Pigalarga, M. P. Osborne, and E. Tousimis, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery,” Am. J. Surg. 192(4), 509–512 (2006).
[Crossref] [PubMed]

Iwakuma, N.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Jabro, G.

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

Jacobs, L.

L. Jacobs, “Positive margins: The challenge continues for breast surgeons,” Ann. Surg. Oncol. 15(5), 1271–1272 (2008).
[Crossref] [PubMed]

Jakesz, R.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Jaumot, J.

J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, “A graphical user-friendly interface for mcr-als: A new tool for multivariate curve resolution in matlab,” Chemometr. Intell. Lab 76(1), 101–110 (2005).
[Crossref]

Jeffrey, S. S.

M. C. Smitt, K. Nowels, R. W. Carlson, and S. S. Jeffrey, “Predictors of reexcision findings and recurrence after breast conservation,” Int. J. Radiat. Oncol. Biol. Phys. 57(4), 979–985 (2003).
[Crossref] [PubMed]

Jensen, S. C.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Jeong, J. H.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Jeong, J. W.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Jiang, H.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Johnson, P. A.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Junker, M.

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Junker, M. K.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Kalinsky, K.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Kaplan, J.

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

Karpiouk, A.

Kelder, W.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Keller, M. D.

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

Kelley, M. C.

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg. 71(1), 22–27 (2005).
[PubMed]

Kennedy, S.

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Kennedy, S. A.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Khamapirad, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Kharine, A.

S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
[Crossref] [PubMed]

Kim, H. K.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Kim, J. W.

J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
[Crossref] [PubMed]

Klipfel, N. E.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Konecky, S. D.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Kong, A.

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

Kotynek, J. G.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Ku, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Kuerer, H. M.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Lacewell, R.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Lambert, P.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Lanning, R.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Laufer, J.

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

Lê, M. G.

R. Arriagada, M. G. Lê, F. Rochard, G. Contesso, and Institut Gustave-Roussy Breast Cancer Group, “Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data,” J. Clin. Oncol. 14(5), 1558–1564 (1996).
[PubMed]

Lee, K.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Legrand, C.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Leonard, M. H.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Levêque, J.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Li, R.

J. R. Rajian, R. Li, P. Wang, and J. X. Cheng, “Vibrational photoacoustic tomography: Chemical imaging beyond the ballistic regime,” J. Phys. Chem. Lett. 4(19), 3211–3215 (2013).
[Crossref] [PubMed]

R. Li, M. N. Slipchenko, P. Wang, and J. X. Cheng, “Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat,” J. Biomed. Opt. 18(4), 040502 (2013).
[Crossref] [PubMed]

Liang, S.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Lickley, H. L.

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

Lim, E. A.

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

Ling, L.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Litovsky, S.

Liu, X.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Low, P. S.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Lucht, R.

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Luini, A.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Lyons, J.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Ma, T.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Mader, N.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Mahadevan-Jansen, A.

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

Majumder, S. K.

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

Manohar, S.

D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
[Crossref] [PubMed]

Marchese, R.

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

Margenthaler, J. A.

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

Margolese, R. G.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Mariani, L.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Marmarelis, V. Z.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Marubini, E.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Mc Dermott, E. W.

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

McCready, D. R.

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

McNeill, J.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Mehta, K.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Meric-Bernstam, F.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Meshba, H.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Meszoely, I. M.

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

Miller, T.

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Mithani, S. K.

G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg. 71(1), 22–27 (2005).
[PubMed]

Mittlboeck, M.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Moon, H. M.

J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
[Crossref] [PubMed]

Moudgil, B. M.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Mycek, M. A.

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

Narod, S. A.

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

Nazemi, J.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Neumayer, L. A.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Nguyen, F. T.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Nowels, K.

M. C. Smitt, K. Nowels, R. W. Carlson, and S. S. Jeffrey, “Predictors of reexcision findings and recurrence after breast conservation,” Int. J. Radiat. Oncol. Biol. Phys. 57(4), 979–985 (2003).
[Crossref] [PubMed]

Ntziachristos, V.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

O’Doherty, A.

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

O’Higgins, N.

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

O’Higgins, N. J.

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

Oliphant, U. J.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Olivares, G. M.

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

Oraevsky, A. A.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

Osborne, M. P.

T. L. Huston, R. Pigalarga, M. P. Osborne, and E. Tousimis, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery,” Am. J. Surg. 192(4), 509–512 (2006).
[Crossref] [PubMed]

Pan, H.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Pang, Y.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Patel, H.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Pathak, S.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Pham, T.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Pigalarga, R.

T. L. Huston, R. Pigalarga, M. P. Osborne, and E. Tousimis, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery,” Am. J. Surg. 192(4), 509–512 (2006).
[Crossref] [PubMed]

Piras, D.

D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Pleijhuis, R. G.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Putt, M. E.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Quinn, C. M.

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

Rajian, J. R.

J. R. Rajian, R. Li, P. Wang, and J. X. Cheng, “Vibrational photoacoustic tomography: Chemical imaging beyond the ballistic regime,” J. Phys. Chem. Lett. 4(19), 3211–3215 (2013).
[Crossref] [PubMed]

P. Wang, J. R. Rajian, and J. X. Cheng, “Spectroscopic imaging of deep tissue through photoacoustic detection of molecular vibration,” J. Phys. Chem. Lett. 4(13), 2177–2185 (2013).
[Crossref] [PubMed]

Ramanujam, N.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Rawlinson, E.

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

Richards, L. M.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Riedl, O.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Rochard, F.

R. Arriagada, M. G. Lê, F. Rochard, G. Contesso, and Institut Gustave-Roussy Breast Cancer Group, “Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data,” J. Clin. Oncol. 14(5), 1558–1564 (1996).
[PubMed]

Rosen, M. A.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Ross, M. I.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Rouquette, S.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Rowe, J. W.

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Rowland, K. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Roy, S.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Rudas, M.

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Ruthazer, R.

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

Saccozzi, R.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Safaii, H.

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

Sahin, A. A.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Sarantopoulos, A.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Schmid, C.

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

Schmidt-Ullrich, R. K.

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

Schnall, M. D.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Schweiger, M.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Shah, N.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Sharma, P.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Shashkov, E. V.

J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
[Crossref] [PubMed]

Shaw, J. A.

A. J. Creager, J. A. Shaw, P. R. Young, and K. R. Geisinger, “Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: A community hospital experience,” Arch. Pathol. Lab. Med. 126(7), 846–848 (2002).
[PubMed]

Shin, D. C.

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Shung, K. K.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Simpson, J. F.

G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg. 71(1), 22–27 (2005).
[PubMed]

Singletary, S. E.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Slipchenko, M. N.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

R. Li, M. N. Slipchenko, P. Wang, and J. X. Cheng, “Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat,” J. Biomed. Opt. 18(4), 040502 (2013).
[Crossref] [PubMed]

Smalling, R.

Smitt, M. C.

M. C. Smitt, K. Nowels, R. W. Carlson, and S. S. Jeffrey, “Predictors of reexcision findings and recurrence after breast conservation,” Int. J. Radiat. Oncol. Biol. Phys. 57(4), 979–985 (2003).
[Crossref] [PubMed]

Sorensen, K. M.

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Steenbergen, W.

D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
[Crossref] [PubMed]

Stoica, G.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Sturek, M.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Su, R.

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

Sun, P.

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

Svaasand, L.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Sylvester, R. J.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Tartter, P. I.

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

Tas, P.

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

Tauler, R.

J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, “A graphical user-friendly interface for mcr-als: A new tool for multivariate curve resolution in matlab,” Chemometr. Intell. Lab 76(1), 101–110 (2005).
[Crossref]

Tchou, J.

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Themelis, G.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Thill, M.

M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
[Crossref] [PubMed]

M. Thill, “MarginProbe: Intraoperative margin assessment during breast conserving surgery by using radiofrequency spectroscopy,” Expert Rev. Med. Devices 10(3), 301–315 (2013).
[Crossref] [PubMed]

Tian, L.

K. E. Wilson, S. V. Bachawal, L. Tian, and J. K. Willmann, “Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model,” Theranostics 4(11), 1062–1071 (2014).
[Crossref] [PubMed]

Tong, D.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Tousimis, E.

T. L. Huston, R. Pigalarga, M. P. Osborne, and E. Tousimis, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery,” Am. J. Surg. 192(4), 509–512 (2006).
[Crossref] [PubMed]

Tromberg, B. J.

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Umulis, D.

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Ursini, L. A.

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

van Dam, G. M.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

van der Schueren, E.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

van der Zee, A. G. J.

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

van Dongen, J. A.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

van Hespen, J. C.

S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
[Crossref] [PubMed]

van Leeuwen, T. G.

D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
[Crossref] [PubMed]

van Zijl, K.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Vargis, E.

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

Veronesi, U.

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

Volynskaya, Z.

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Voogd, A. C.

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

Wang, B.

Wang, H. W.

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Wang, L. V.

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Wang, P.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

R. Li, M. N. Slipchenko, P. Wang, and J. X. Cheng, “Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat,” J. Biomed. Opt. 18(4), 040502 (2013).
[Crossref] [PubMed]

J. R. Rajian, R. Li, P. Wang, and J. X. Cheng, “Vibrational photoacoustic tomography: Chemical imaging beyond the ballistic regime,” J. Phys. Chem. Lett. 4(19), 3211–3215 (2013).
[Crossref] [PubMed]

P. Wang, J. R. Rajian, and J. X. Cheng, “Spectroscopic imaging of deep tissue through photoacoustic detection of molecular vibration,” J. Phys. Chem. Lett. 4(13), 2177–2185 (2013).
[Crossref] [PubMed]

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

Wang, S.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Wang, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Wazer, D. E.

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

Whitman, G. J.

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Wilke, L.

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Wilke, L. G.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Willmann, J. K.

K. E. Wilson, S. V. Bachawal, L. Tian, and J. K. Willmann, “Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model,” Theranostics 4(11), 1062–1071 (2014).
[Crossref] [PubMed]

Wilson, K. E.

K. E. Wilson, S. V. Bachawal, L. Tian, and J. K. Willmann, “Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model,” Theranostics 4(11), 1062–1071 (2014).
[Crossref] [PubMed]

Wilson, R. H.

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

Wolmark, N.

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

Wu, C.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Wu, N.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Xia, W. F.

D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Xie, X.

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Yeager, D.

Yodh, A. G.

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

Young, P. R.

A. J. Creager, J. A. Shaw, P. R. Young, and K. R. Geisinger, “Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: A community hospital experience,” Arch. Pathol. Lab. Med. 126(7), 846–848 (2002).
[PubMed]

Yu, B.

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

Zapetti, D.

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

Zha, X.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Zhang, Q.

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Zharov, V. P.

J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
[Crossref] [PubMed]

Zhou, Q.

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Zhou, W.

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Zysk, A. M.

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

Am. J. Surg. (2)

P. I. Tartter, J. Kaplan, I. Bleiweiss, C. Gajdos, A. Kong, S. Ahmed, and D. Zapetti, “Lumpectomy margins, reexcision, and local recurrence of breast cancer,” Am. J. Surg. 179(2), 81–85 (2000).
[Crossref] [PubMed]

T. L. Huston, R. Pigalarga, M. P. Osborne, and E. Tousimis, “The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery,” Am. J. Surg. 192(4), 509–512 (2006).
[Crossref] [PubMed]

Am. Surg. (1)

G. C. Balch, S. K. Mithani, J. F. Simpson, and M. C. Kelley, “Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy,” Am. Surg. 71(1), 22–27 (2005).
[PubMed]

Ann. Surg. Oncol. (3)

L. Jacobs, “Positive margins: The challenge continues for breast surgeons,” Ann. Surg. Oncol. 15(5), 1271–1272 (2008).
[Crossref] [PubMed]

M. F. Dillon, E. W. Mc Dermott, A. O’Doherty, C. M. Quinn, A. D. Hill, and N. O’Higgins, “Factors affecting successful breast conservation for ductal carcinoma in situ,” Ann. Surg. Oncol. 14(5), 1618–1628 (2007).
[Crossref] [PubMed]

N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, “Role for intraoperative margin assessment in patients undergoing breast-conserving surgery,” Ann. Surg. Oncol. 14(4), 1458–1471 (2007).
[Crossref] [PubMed]

Arch. Pathol. Lab. Med. (1)

A. J. Creager, J. A. Shaw, P. R. Young, and K. R. Geisinger, “Intraoperative evaluation of lumpectomy margins by imprint cytology with histologic correlation: A community hospital experience,” Arch. Pathol. Lab. Med. 126(7), 846–848 (2002).
[PubMed]

BMC Cancer (1)

T. E. Doyle, R. E. Factor, C. L. Ellefson, K. M. Sorensen, B. J. Ambrose, J. B. Goodrich, V. P. Hart, S. C. Jensen, H. Patel, and L. A. Neumayer, “High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: A feasibility study,” BMC Cancer 11(1), 444 (2011).
[Crossref] [PubMed]

Breast (2)

F. D’Halluin, P. Tas, S. Rouquette, C. Bendavid, F. Foucher, H. Meshba, J. Blanchot, O. Coué, and J. Levêque, “Intra-operative touch preparation cytology following lumpectomy for breast cancer: A series of 400 procedures,” Breast 18(4), 248–253 (2009).
[Crossref] [PubMed]

M. Thill, C. Dittmer, K. Baumann, K. Friedrichs, and J. U. Blohmer, “MarginProbe®--final results of the german post-market study in breast conserving surgery of ductal carcinoma in situ,” Breast 23(1), 94–96 (2014).
[Crossref] [PubMed]

Breast Cancer Res. (1)

S. Kennedy, J. Geradts, T. Bydlon, J. Q. Brown, J. Gallagher, M. Junker, W. Barry, N. Ramanujam, and L. Wilke, “Optical breast cancer margin assessment: An observational study of the effects of tissue heterogeneity on optical contrast,” Breast Cancer Res. 12(6), R91 (2010).
[Crossref] [PubMed]

Breast Cancer Res. Treat. (1)

G. A. Cèfaro, D. Genovesi, R. Marchese, L. A. Ursini, E. Cianchetti, E. Ballone, and M. Di Nicola, “Predictors of local recurrence after conservative surgery and whole-breast irradiation,” Breast Cancer Res. Treat. 98(3), 329–335 (2006).
[Crossref] [PubMed]

Breast J. (1)

D. Aziz, E. Rawlinson, S. A. Narod, P. Sun, H. L. Lickley, D. R. McCready, and C. M. Holloway, “The role of reexcision for positive margins in optimizing local disease control after breast-conserving surgery for cancer,” Breast J. 12(4), 331–337 (2006).
[Crossref] [PubMed]

Cancer Res. (2)

F. T. Nguyen, A. M. Zysk, E. J. Chaney, J. G. Kotynek, U. J. Oliphant, F. J. Bellafiore, K. M. Rowland, P. A. Johnson, and S. A. Boppart, “Intraoperative evaluation of breast tumor margins with optical coherence tomography,” Cancer Res. 69(22), 8790–8796 (2009).
[Crossref] [PubMed]

A. S. Haka, Z. Volynskaya, J. A. Gardecki, J. Nazemi, J. Lyons, D. Hicks, M. Fitzmaurice, R. R. Dasari, J. P. Crowe, and M. S. Feld, “In vivo margin assessment during partial mastectomy breast surgery using raman spectroscopy,” Cancer Res. 66(6), 3317–3322 (2006).
[Crossref] [PubMed]

Chemometr. Intell. Lab (1)

J. Jaumot, R. Gargallo, A. de Juan, and R. Tauler, “A graphical user-friendly interface for mcr-als: A new tool for multivariate curve resolution in matlab,” Chemometr. Intell. Lab 76(1), 101–110 (2005).
[Crossref]

Eur. J. Surg. Oncol. (2)

F. J. Fleming, A. D. K. Hill, E. W. Mc Dermott, A. O’Doherty, N. J. O’Higgins, and C. M. Quinn, “Intraoperative margin assessment and re-excision rate in breast conserving surgery,” Eur. J. Surg. Oncol. 30(3), 233–237 (2004).
[Crossref] [PubMed]

O. Riedl, F. Fitzal, N. Mader, P. Dubsky, M. Rudas, M. Mittlboeck, M. Gnant, and R. Jakesz, “Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer,” Eur. J. Surg. Oncol. 35(3), 264–270 (2009).
[Crossref] [PubMed]

Expert Rev. Med. Devices (1)

M. Thill, “MarginProbe: Intraoperative margin assessment during breast conserving surgery by using radiofrequency spectroscopy,” Expert Rev. Med. Devices 10(3), 301–315 (2013).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (2)

J. Q. Brown, T. M. Bydlon, L. M. Richards, B. Yu, S. A. Kennedy, J. Geradts, L. G. Wilke, M. K. Junker, J. Gallagher, W. T. Barry, and N. Ramanujam, “Optical assessment of tumor resection margins in the breast,” IEEE J. Sel. Top. Quantum Electron. 16(3), 530–544 (2010).
[Crossref] [PubMed]

D. Piras, W. F. Xia, W. Steenbergen, T. G. van Leeuwen, and S. Manohar, “Photoacoustic imaging of the breast using the twente photoacoustic mammoscope: Present status and future perspectives,” IEEE J. Sel. Top. Quantum Electron. 16(4), 730–739 (2010).
[Crossref]

Int. J. Radiat. Oncol. Biol. Phys. (1)

M. C. Smitt, K. Nowels, R. W. Carlson, and S. S. Jeffrey, “Predictors of reexcision findings and recurrence after breast conservation,” Int. J. Radiat. Oncol. Biol. Phys. 57(4), 979–985 (2003).
[Crossref] [PubMed]

J. Am. Coll. Surg. (1)

J. C. Cendán, D. Coco, and E. M. Copeland, “Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins,” J. Am. Coll. Surg. 201(2), 194–198 (2005).
[Crossref] [PubMed]

J. Biomed. Opt. (7)

M. D. Keller, E. Vargis, N. de Matos Granja, R. H. Wilson, M. A. Mycek, M. C. Kelley, and A. Mahadevan-Jansen, “Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation,” J. Biomed. Opt. 16(7), 077006 (2011).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

M. L. Flexman, H. K. Kim, J. E. Gunther, E. A. Lim, M. C. Alvarez, E. Desperito, K. Kalinsky, D. L. Hershman, and A. H. Hielscher, “Optical biomarkers for breast cancer derived from dynamic diffuse optical tomography,” J. Biomed. Opt. 18(9), 096012 (2013).
[Crossref] [PubMed]

R. Choe, S. D. Konecky, A. Corlu, K. Lee, T. Durduran, D. R. Busch, S. Pathak, B. J. Czerniecki, J. Tchou, D. L. Fraker, A. Demichele, B. Chance, S. R. Arridge, M. Schweiger, J. P. Culver, M. D. Schnall, M. E. Putt, M. A. Rosen, and A. G. Yodh, “Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography,” J. Biomed. Opt. 14(2), 024020 (2009).
[Crossref] [PubMed]

H. P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky, “Whole-body three-dimensional optoacoustic tomography system for small animals,” J. Biomed. Opt. 14(6), 064007 (2009).
[Crossref] [PubMed]

R. Li, M. N. Slipchenko, P. Wang, and J. X. Cheng, “Compact high power barium nitrite crystal-based Raman laser at 1197 nm for photoacoustic imaging of fat,” J. Biomed. Opt. 18(4), 040502 (2013).
[Crossref] [PubMed]

S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt. 14(2), 024007 (2009).
[Crossref] [PubMed]

J. Clin. Oncol. (1)

R. Arriagada, M. G. Lê, F. Rochard, G. Contesso, and Institut Gustave-Roussy Breast Cancer Group, “Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data,” J. Clin. Oncol. 14(5), 1558–1564 (1996).
[PubMed]

J. Natl. Cancer Inst. (1)

J. A. van Dongen, A. C. Voogd, I. S. Fentiman, C. Legrand, R. J. Sylvester, D. Tong, E. van der Schueren, P. A. Helle, K. van Zijl, and H. Bartelink, “Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European organization for research and treatment of cancer 10801 trial,” J. Natl. Cancer Inst. 92(14), 1143–1150 (2000).
[Crossref] [PubMed]

J. Phys. Chem. Lett. (2)

J. R. Rajian, R. Li, P. Wang, and J. X. Cheng, “Vibrational photoacoustic tomography: Chemical imaging beyond the ballistic regime,” J. Phys. Chem. Lett. 4(19), 3211–3215 (2013).
[Crossref] [PubMed]

P. Wang, J. R. Rajian, and J. X. Cheng, “Spectroscopic imaging of deep tissue through photoacoustic detection of molecular vibration,” J. Phys. Chem. Lett. 4(13), 2177–2185 (2013).
[Crossref] [PubMed]

J. Surg. Res. (1)

J. Atkins, F. Al Mushawah, C. M. Appleton, A. E. Cyr, W. E. Gillanders, R. L. Aft, T. J. Eberlein, F. Gao, and J. A. Margenthaler, “Positive margin rates following breast-conserving surgery for stage i-iii breast cancer: Palpable versus nonpalpable tumors,” J. Surg. Res. 177(1), 109–115 (2012).
[Crossref] [PubMed]

J. Ultrasound Med. (1)

J. W. Jeong, D. C. Shin, S. H. Do, C. Blanco, N. E. Klipfel, D. R. Holmes, L. J. Hovanessian-Larsen, and V. Z. Marmarelis, “Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography,” J. Ultrasound Med. 27(3), 435–451 (2008).
[PubMed]

Lasers Surg. Med. (1)

M. D. Keller, S. K. Majumder, M. C. Kelley, I. M. Meszoely, F. I. Boulos, G. M. Olivares, and A. Mahadevan-Jansen, “Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis,” Lasers Surg. Med. 42(1), 15–23 (2010).
[Crossref] [PubMed]

N. Engl. J. Med. (3)

B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J. H. Jeong, and N. Wolmark, “Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer,” N. Engl. J. Med. 347(16), 1233–1241 (2002).
[Crossref] [PubMed]

U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, “Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer,” N. Engl. J. Med. 347(16), 1227–1232 (2002).
[Crossref] [PubMed]

J. Folkman, M. Bach, J. W. Rowe, F. Davidoff, P. Lambert, C. Hirsch, A. Goldberg, H. H. Hiatt, J. Glass, and E. Henshaw, “Tumor angiogenesis: therapeutic implications,” N. Engl. J. Med. 285(21), 1182–1186 (1971).
[Crossref] [PubMed]

Nanotechnology (1)

Q. Zhang, N. Iwakuma, P. Sharma, B. M. Moudgil, C. Wu, J. McNeill, H. Jiang, and S. R. Grobmyer, “Gold nanoparticles as a contrast agent for in vivo tumor imaging with photoacoustic tomography,” Nanotechnology 20(39), 395102 (2009).
[Crossref] [PubMed]

Nat. Biotechnol. (1)

X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003).
[Crossref] [PubMed]

Nat. Med. (1)

G. M. van Dam, G. Themelis, L. M. A. Crane, N. J. Harlaar, R. G. Pleijhuis, W. Kelder, A. Sarantopoulos, J. S. de Jong, H. J. G. Arts, A. G. J. van der Zee, J. Bart, P. S. Low, and V. Ntziachristos, “Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results,” Nat. Med. 17(10), 1315–1319 (2011).
[Crossref] [PubMed]

Nat. Nanotechnol. (1)

J. W. Kim, E. I. Galanzha, E. V. Shashkov, H. M. Moon, and V. P. Zharov, “Golden carbon nanotubes as multimodal photoacoustic and photothermal high-contrast molecular agents,” Nat. Nanotechnol. 4(10), 688–694 (2009).
[Crossref] [PubMed]

Neoplasia (1)

B. J. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand, and J. Butler, “Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy,” Neoplasia 2(1-2), 26–40 (2000).
[Crossref] [PubMed]

Opt. Lett. (1)

PET Clin. (1)

D. R. Busch, R. Choe, T. Durduran, and A. G. Yodh, “Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics,” PET Clin. 8(3), 345–365 (2013).
[Crossref] [PubMed]

Phys. Med. Biol. (2)

J. Laufer, D. Delpy, C. Elwell, and P. Beard, “Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: Application to the measurement of blood oxygenation and haemoglobin concentration,” Phys. Med. Biol. 52(1), 141–168 (2007).
[Crossref] [PubMed]

S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The twente photoacoustic mammoscope: System overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005).
[Crossref] [PubMed]

Phys. Rev. Lett. (1)

H. W. Wang, N. Chai, P. Wang, S. Hu, W. Dou, D. Umulis, L. V. Wang, M. Sturek, R. Lucht, and J. X. Cheng, “Label-free bond-selective imaging by listening to vibrationally excited molecules,” Phys. Rev. Lett. 106(23), 238106 (2011).
[Crossref] [PubMed]

PLoS ONE (1)

H. Pan, N. Wu, H. Ding, Q. Ding, J. Dai, L. Ling, L. Chen, X. Zha, X. Liu, W. Zhou, and S. Wang, “Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: A systematic review and meta-analysis,” PLoS ONE 8(9), e74028 (2013).
[Crossref] [PubMed]

Radiat. Oncol. Investig. (1)

D. E. Wazer, G. Jabro, R. Ruthazer, C. Schmid, H. Safaii, and R. K. Schmidt-Ullrich, “Extent of margin positivity as a predictor for local recurrence after breast conserving irradiation,” Radiat. Oncol. Investig. 7(2), 111–117 (1999).
[Crossref] [PubMed]

Sci. Rep. (1)

P. Wang, T. Ma, M. N. Slipchenko, S. Liang, J. Hui, K. K. Shung, S. Roy, M. Sturek, Q. Zhou, Z. Chen, and J.-X. Cheng, “High-speed intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque enabled by a 2-kHz barium nitrite raman laser,” Sci. Rep. 4, 6889 (2014).
[Crossref] [PubMed]

Theranostics (1)

K. E. Wilson, S. V. Bachawal, L. Tian, and J. K. Willmann, “Multiparametric spectroscopic photoacoustic imaging of breast cancer development in a transgenic mouse model,” Theranostics 4(11), 1062–1071 (2014).
[Crossref] [PubMed]

Other (1)

L. W. Jerry Workman, Practical Guide to Interpretive Near-Infrared Spectroscopy (CRC press, 2007).

Cited By

OSA participates in Crossref's Cited-By Linking service. Citing articles from OSA journals and other participating publishers are listed here.

Alert me when this article is cited.


Figures (3)

Fig. 1
Fig. 1 Multispectral PAT system and multivariate data analysis method. (A) Experimental setup of multispectral PAT. (B) Photoacoustic image of a polyethylene film with 40 µm thickness illuminated at 1210 nm wavelength. (C) Illustration of MCR-ALS analysis.
Fig. 2
Fig. 2 Spectroscopic PA study of the excised breast tissue from human. (A) Ultrasound image. (B) Image of component 1 showing the hemoglobin contrast. (C) Image of component 2 showing the fat contrast. (D) The merged image indicating an imaging depth of 3 mm. (E) Spectra of components 1 and 2. (F) H&E histology image.
Fig. 3
Fig. 3 Distinguishing different types of breast tumor margins. (A, B, C) shows a positive margin imaged by ultrasound and PAT, separately. The analyzed tissue type map with normal tissue in magenta and cancer tissue in blue is shown in (D). The result was confirmed by histological image (E). (F, G, H) shows a typical negative margin imaged by ultrasound and PAT, separately. The analyzed tissue type map is shown in (I). The result was confirmed by histological image (J).

Tables (2)

Tables Icon

Table 1 Technologies for intraoperative tumor margin assessment. mm: millimeter.

Tables Icon

Table 2 Results of margin assessment using multispectral PAT

Equations (1)

Equations on this page are rendered with MathJax. Learn more.

D=C S T +E

Metrics