Abstract

In this study, a temporal focusing-based high-throughput multiphoton-induced ablation system with axially-resolved widefield multiphoton excitation has been successfully applied to rapidly disrupt biotissues. Experimental results demonstrate that this technique features high efficiency for achieving large-area laser ablation without causing serious photothermal damage in non-ablated regions. Furthermore, the rate of tissue processing can reach around 1.6 × 106 μm3/s in chicken tendon. Moreover, the temporal focusing-based multiphoton system can be efficiently utilized in optical imaging through iterating high-throughput multiphoton-induced ablation machining followed by widefield optical sectioning; hence, it has the potential to obtain molecular images for a whole bio-specimen.

© 2015 Optical Society of America

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References

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2014 (3)

2013 (2)

2012 (3)

2011 (2)

2010 (3)

2009 (1)

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

2008 (3)

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

A. Vaziri, J. Tang, H. Shroff, and C. V. Shank, “Multilayer three-dimensional super resolution imaging of thick biological samples,” Proc. Natl. Acad. Sci. U.S.A. 105(51), 20221–20226 (2008).
[Crossref] [PubMed]

M. E. Durst, G. Zhu, and C. Xu, “Simultaneous spatial and temporal focusing in nonlinear microscopy,” Opt. Commun. 281(7), 1796–1805 (2008).
[Crossref] [PubMed]

2007 (1)

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

2006 (1)

2005 (5)

2004 (1)

2003 (2)

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

2001 (3)

1999 (1)

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

1998 (1)

R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger, and T. Juhasz, “Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,” J. Refract. Surg. 14(5), 541–548 (1998).
[PubMed]

1996 (1)

T. Juhasz, G. A. Kastis, C. Suárez, Z. Bor, and W. E. Bron, “Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,” Lasers Surg. Med. 19(1), 23–31 (1996).
[Crossref] [PubMed]

1995 (1)

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

1993 (1)

K. S. Frederickson, W. E. White, R. G. Wheeland, and D. R. Slaughter, “Precise ablation of skin with reduced collateral damage using the femtosecond-pulsed, terawatt titanium-sapphire laser,” Arch. Dermatol. 129(8), 989–993 (1993).
[Crossref] [PubMed]

1986 (1)

Ackermann, R.

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

Ammar, D. A.

Anselmi, F.

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Arakawa, N.

Aubé, B.

Bègue, A.

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Bille, J. F.

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

Blinder, P.

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

Block, E.

Bor, Z.

T. Juhasz, G. A. Kastis, C. Suárez, Z. Bor, and W. E. Bron, “Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,” Lasers Surg. Med. 19(1), 23–31 (1996).
[Crossref] [PubMed]

Brodeur, A.

Bron, W. E.

T. Juhasz, G. A. Kastis, C. Suárez, Z. Bor, and W. E. Bron, “Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,” Lasers Surg. Med. 19(1), 23–31 (1996).
[Crossref] [PubMed]

Bückle, R.

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

Buffelli, M.

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

Campagnola, P. J.

Cerami, L. R.

Chang, C. Y.

Chang, C.-Y.

Chang, N.-S.

Chen, S. J.

Chen, S.-J.

Cheng, L.-C.

Chien, F. C.

Cho, K.-C.

Côté, D.

Da Sie, Y.

de Sars, V.

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Deutsch, M.

Dong, C. Y.

C.-Y. Chang, L.-C. Cheng, H.-W. Su, Y. Y. Hu, K.-C. Cho, W.-C. Yen, C. Xu, C. Y. Dong, and S.-J. Chen, “Wavefront sensorless adaptive optics temporal focusing-based multiphoton microscopy,” Biomed. Opt. Express 5(6), 1768–1777 (2014).
[Crossref] [PubMed]

L.-C. Cheng, C.-H. Lien, Y. Da Sie, Y. Y. Hu, C. Y. Lin, F. C. Chien, C. Xu, C. Y. Dong, and S. J. Chen, “Nonlinear structured-illumination enhanced temporal focusing multiphoton excitation microscopy with a digital micromirror device,” Biomed. Opt. Express 5(8), 2526–2536 (2014).
[Crossref] [PubMed]

L.-C. Cheng, C.-Y. Chang, C.-Y. Lin, K.-C. Cho, W.-C. Yen, N.-S. Chang, C. Xu, C. Y. Dong, and S.-J. Chen, “Spatiotemporal focusing-based widefield multiphoton microscopy for fast optical sectioning,” Opt. Express 20(8), 8939–8948 (2012).
[Crossref] [PubMed]

C.-Y. Lin, C.-H. Lien, K.-C. Cho, C.-Y. Chang, N.-S. Chang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “Investigation of two-photon excited fluorescence increment via crosslinked bovine serum albumin,” Opt. Express 20(13), 13669–13676 (2012).
[Crossref] [PubMed]

K.-C. Cho, C.-H. Lien, C.-Y. Lin, C.-Y. Chang, L. L. H. Huang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “Enhanced two-photon excited fluorescence in three-dimensionally crosslinked bovine serum albumin microstructures,” Opt. Express 19(12), 11732–11739 (2011).
[Crossref] [PubMed]

W. S. Kuo, C.-H. Lien, K.-C. Cho, C. Y. Chang, C.-Y. Lin, L. L. Huang, P. J. Campagnola, C. Y. Dong, and S. J. Chen, “Multiphoton fabrication of freeform polymer microstructures with gold nanorods,” Opt. Express 18(26), 27550–27559 (2010).
[Crossref] [PubMed]

Du, D.

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

Durfee, C.

Durst, M.

Durst, M. E.

M. E. Durst, G. Zhu, and C. Xu, “Simultaneous spatial and temporal focusing in nonlinear microscopy,” Opt. Commun. 281(7), 1796–1805 (2008).
[Crossref] [PubMed]

Dutta, S.

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

Emiliani, V.

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Frederickson, K. S.

K. S. Frederickson, W. E. White, R. G. Wheeland, and D. R. Slaughter, “Precise ablation of skin with reduced collateral damage using the femtosecond-pulsed, terawatt titanium-sapphire laser,” Arch. Dermatol. 129(8), 989–993 (1993).
[Crossref] [PubMed]

Freund, I.

Friedman, B.

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Fritzsche, W.

Fujita, K.

N. I. Smith, K. Fujita, O. Nakamura, and S. Kawata, “Three-dimensional subsurface microprocessing of collagen by ultrashort laser pulses,” Appl. Phys. Lett. 78(7), 999–1001 (2001).
[Crossref]

Fukui, K.

García, J. F.

Gattass, R. R.

Glückstad, J.

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Gorjup, E.

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

Götte, J.

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

Greco, M.

Heisterkamp, A.

Higashi, T.

Horvath, C.

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger, and T. Juhasz, “Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,” J. Refract. Surg. 14(5), 541–548 (1998).
[PubMed]

Hu, Y. Y.

Huang, L. L.

Huang, L. L. H.

Huttman, G.

A. Vogel, J. Noack, G. Huttman, and G. Paltauf, “Mechanisms of femtosecond laser nanosurgery of cells and tissues,” Appl. Phys. B 81(8), 1015–1047 (2005).
[Crossref]

Ifarraguerri, A. I.

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Ingber, D. E.

Isacoff, E. Y.

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Isemann, A.

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

Isobe, K.

Itoh, K.

Jasaitis, A.

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

Jin, Y.

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

Juhasz, T.

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger, and T. Juhasz, “Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,” J. Refract. Surg. 14(5), 541–548 (1998).
[PubMed]

T. Juhasz, G. A. Kastis, C. Suárez, Z. Bor, and W. E. Bron, “Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,” Lasers Surg. Med. 19(1), 23–31 (1996).
[Crossref] [PubMed]

Kahook, M. Y.

Kammel, R.

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

Kastis, G. A.

T. Juhasz, G. A. Kastis, C. Suárez, Z. Bor, and W. E. Bron, “Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,” Lasers Surg. Med. 19(1), 23–31 (1996).
[Crossref] [PubMed]

Kawata, S.

N. I. Smith, K. Fujita, O. Nakamura, and S. Kawata, “Three-dimensional subsurface microprocessing of collagen by ultrashort laser pulses,” Appl. Phys. Lett. 78(7), 999–1001 (2001).
[Crossref]

Kleinfeld, D.

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

König, K.

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

K. König, I. Riemann, and W. Fritzsche, “Nanodissection of human chromosomes with near-infrared femtosecond laser pulses,” Opt. Lett. 26(11), 819–821 (2001).
[Crossref] [PubMed]

Koninck, P. D.

Krueger, R. R.

R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger, and T. Juhasz, “Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,” J. Refract. Surg. 14(5), 541–548 (1998).
[PubMed]

Kumar, S.

Kuo, W. S.

Kurtz, R. M.

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger, and T. Juhasz, “Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,” J. Refract. Surg. 14(5), 541–548 (1998).
[PubMed]

Lev-Ram, V.

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Li, Y.-C.

Lien, C.-H.

Lin, C. Y.

Lin, C.-Y.

Liu, H. H.

R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger, and T. Juhasz, “Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,” J. Refract. Surg. 14(5), 541–548 (1998).
[PubMed]

Loesel, F. H.

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

Mandava, N.

Masi, A.

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

Masihzadeh, O.

Matsunaga, S.

Maxwell, I. Z.

Mazur, E.

Migliori, B. J.

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

Mourou, G.

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

Nakamura, O.

N. I. Smith, K. Fujita, O. Nakamura, and S. Kawata, “Three-dimensional subsurface microprocessing of collagen by ultrashort laser pulses,” Appl. Phys. Lett. 78(7), 999–1001 (2001).
[Crossref]

Neev, J.

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

Nickerson, J. A.

Noack, J.

A. Vogel, J. Noack, G. Huttman, and G. Paltauf, “Mechanisms of femtosecond laser nanosurgery of cells and tissues,” Appl. Phys. B 81(8), 1015–1047 (2005).
[Crossref]

Nolte, S.

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

O’Connor, R. P.

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

Oron, D.

Pagès, S.

Paltauf, G.

A. Vogel, J. Noack, G. Huttman, and G. Paltauf, “Mechanisms of femtosecond laser nanosurgery of cells and tissues,” Appl. Phys. B 81(8), 1015–1047 (2005).
[Crossref]

Papagiakoumou, E.

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Pavone, F. S.

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

Pronko, P.

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

Riemann, I.

Rowlands, C.

P. T. C. So, E. Y. S. Yew, and C. Rowlands, “High-throughput nonlinear optical microscopy,” Biophys. J. 105(12), 2641–2654 (2013).
[Crossref] [PubMed]

Rudd, V.

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

Sacconi, L.

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

Schaffer, C. B.

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

C. B. Schaffer, A. Brodeur, J. F. García, and E. Mazur, “Micromachining bulk glass by use of femtosecond laser pulses with nanojoule energy,” Opt. Lett. 26(2), 93–95 (2001).
[Crossref] [PubMed]

Shank, C. V.

A. Vaziri and C. V. Shank, “Ultrafast widefield optical sectioning microscopy by multifocal temporal focusing,” Opt. Express 18(19), 19645–19655 (2010).
[Crossref] [PubMed]

A. Vaziri, J. Tang, H. Shroff, and C. V. Shank, “Multilayer three-dimensional super resolution imaging of thick biological samples,” Proc. Natl. Acad. Sci. U.S.A. 105(51), 20221–20226 (2008).
[Crossref] [PubMed]

Shroff, H.

A. Vaziri, J. Tang, H. Shroff, and C. V. Shank, “Multilayer three-dimensional super resolution imaging of thick biological samples,” Proc. Natl. Acad. Sci. U.S.A. 105(51), 20221–20226 (2008).
[Crossref] [PubMed]

Silberberg, Y.

Skupin, S.

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

Slaughter, D. R.

K. S. Frederickson, W. E. White, R. G. Wheeland, and D. R. Slaughter, “Precise ablation of skin with reduced collateral damage using the femtosecond-pulsed, terawatt titanium-sapphire laser,” Arch. Dermatol. 129(8), 989–993 (1993).
[Crossref] [PubMed]

Smith, N. I.

N. I. Smith, K. Fujita, O. Nakamura, and S. Kawata, “Three-dimensional subsurface microprocessing of collagen by ultrashort laser pulses,” Appl. Phys. Lett. 78(7), 999–1001 (2001).
[Crossref]

So, P. T. C.

P. T. C. So, E. Y. S. Yew, and C. Rowlands, “High-throughput nonlinear optical microscopy,” Biophys. J. 105(12), 2641–2654 (2013).
[Crossref] [PubMed]

Squier, J.

E. Block, M. Greco, D. Vitek, O. Masihzadeh, D. A. Ammar, M. Y. Kahook, N. Mandava, C. Durfee, and J. Squier, “Simultaneous spatial and temporal focusing for tissue ablation,” Biomed. Opt. Express 4(6), 831–841 (2013).
[Crossref] [PubMed]

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

Squier, J. A.

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Su, H.-W.

Suárez, C.

T. Juhasz, G. A. Kastis, C. Suárez, Z. Bor, and W. E. Bron, “Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,” Lasers Surg. Med. 19(1), 23–31 (1996).
[Crossref] [PubMed]

Tal, E.

Tang, J.

A. Vaziri, J. Tang, H. Shroff, and C. V. Shank, “Multilayer three-dimensional super resolution imaging of thick biological samples,” Proc. Natl. Acad. Sci. U.S.A. 105(51), 20221–20226 (2008).
[Crossref] [PubMed]

Tempea, G.

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

Therrien, O. D.

Thomas, J.

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

Thompson, B. D.

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Tsai, P. S.

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Tsien, R. Y.

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Tünnermann, A.

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

Uchugonova, A.

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

Underwood, J. M.

van Howe, J.

Vaziri, A.

A. Vaziri and C. V. Shank, “Ultrafast widefield optical sectioning microscopy by multifocal temporal focusing,” Opt. Express 18(19), 19645–19655 (2010).
[Crossref] [PubMed]

A. Vaziri, J. Tang, H. Shroff, and C. V. Shank, “Multilayer three-dimensional super resolution imaging of thick biological samples,” Proc. Natl. Acad. Sci. U.S.A. 105(51), 20221–20226 (2008).
[Crossref] [PubMed]

Vitek, D.

Vogel, A.

A. Vogel, J. Noack, G. Huttman, and G. Paltauf, “Mechanisms of femtosecond laser nanosurgery of cells and tissues,” Appl. Phys. B 81(8), 1015–1047 (2005).
[Crossref]

Watanabe, W.

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

W. Watanabe, N. Arakawa, S. Matsunaga, T. Higashi, K. Fukui, K. Isobe, and K. Itoh, “Femtosecond laser disruption of subcellular organelles in a living cell,” Opt. Express 12(18), 4203–4213 (2004).
[Crossref] [PubMed]

Webb, W. W.

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

Wheeland, R. G.

K. S. Frederickson, W. E. White, R. G. Wheeland, and D. R. Slaughter, “Precise ablation of skin with reduced collateral damage using the femtosecond-pulsed, terawatt titanium-sapphire laser,” Arch. Dermatol. 129(8), 989–993 (1993).
[Crossref] [PubMed]

White, W. E.

K. S. Frederickson, W. E. White, R. G. Wheeland, and D. R. Slaughter, “Precise ablation of skin with reduced collateral damage using the femtosecond-pulsed, terawatt titanium-sapphire laser,” Arch. Dermatol. 129(8), 989–993 (1993).
[Crossref] [PubMed]

Williams, R. M.

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

Xiong, Q.

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Xu, C.

Yen, W.-C.

Yew, E. Y. S.

P. T. C. So, E. Y. S. Yew, and C. Rowlands, “High-throughput nonlinear optical microscopy,” Biophys. J. 105(12), 2641–2654 (2013).
[Crossref] [PubMed]

Zhu, G.

M. E. Durst, G. Zhu, and C. Xu, “Simultaneous spatial and temporal focusing in nonlinear microscopy,” Opt. Commun. 281(7), 1796–1805 (2008).
[Crossref] [PubMed]

G. Zhu, J. van Howe, M. Durst, W. Zipfel, and C. Xu, “Simultaneous spatial and temporal focusing of femtosecond pulses,” Opt. Express 13(6), 2153–2159 (2005).
[Crossref] [PubMed]

Zipfel, W.

Zipfel, W. R.

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

Appl. Phys. B (1)

A. Vogel, J. Noack, G. Huttman, and G. Paltauf, “Mechanisms of femtosecond laser nanosurgery of cells and tissues,” Appl. Phys. B 81(8), 1015–1047 (2005).
[Crossref]

Appl. Phys. Lett. (1)

N. I. Smith, K. Fujita, O. Nakamura, and S. Kawata, “Three-dimensional subsurface microprocessing of collagen by ultrashort laser pulses,” Appl. Phys. Lett. 78(7), 999–1001 (2001).
[Crossref]

Arch. Dermatol. (1)

K. S. Frederickson, W. E. White, R. G. Wheeland, and D. R. Slaughter, “Precise ablation of skin with reduced collateral damage using the femtosecond-pulsed, terawatt titanium-sapphire laser,” Arch. Dermatol. 129(8), 989–993 (1993).
[Crossref] [PubMed]

Biomed. Opt. Express (4)

Biophys. J. (1)

P. T. C. So, E. Y. S. Yew, and C. Rowlands, “High-throughput nonlinear optical microscopy,” Biophys. J. 105(12), 2641–2654 (2013).
[Crossref] [PubMed]

Curr. Opin. Biotechnol. (1)

P. S. Tsai, P. Blinder, B. J. Migliori, J. Neev, Y. Jin, J. A. Squier, and D. Kleinfeld, “Plasma-mediated ablation: an optical tool for submicrometer surgery on neuronal and vascular systems,” Curr. Opin. Biotechnol. 20(1), 90–99 (2009).
[Crossref] [PubMed]

IEEE J. Sel. Top. Quantum Electron. (1)

T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille, and G. Mourou, “Corneal refractive surgery with femtosecond lasers,” IEEE J. Sel. Top. Quantum Electron. 5(4), 902–910 (1999).
[Crossref]

J. Biomed. Opt. (1)

L. Sacconi, R. P. O’Connor, A. Jasaitis, A. Masi, M. Buffelli, and F. S. Pavone, “In vivo multiphoton nanosurgery on cortical neurons,” J. Biomed. Opt. 12(5), 050502 (2007).
[Crossref] [PubMed]

J. Biophotonics (1)

A. Uchugonova, A. Isemann, E. Gorjup, G. Tempea, R. Bückle, W. Watanabe, and K. König, “Optical knock out of stem cells with extremely ultrashort femtosecond laser pulses,” J. Biophotonics 1(6), 463–469 (2008).
[Crossref] [PubMed]

J. Refract. Surg. (1)

R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger, and T. Juhasz, “Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,” J. Refract. Surg. 14(5), 541–548 (1998).
[PubMed]

Lasers Surg. Med. (1)

T. Juhasz, G. A. Kastis, C. Suárez, Z. Bor, and W. E. Bron, “Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,” Lasers Surg. Med. 19(1), 23–31 (1996).
[Crossref] [PubMed]

Light-Sci. Appl. (1)

R. Kammel, R. Ackermann, J. Thomas, J. Götte, S. Skupin, A. Tünnermann, and S. Nolte, “Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing,” Light-Sci. Appl. 3, e169 (2014).

Nat. Biotechnol. (1)

W. R. Zipfel, R. M. Williams, and W. W. Webb, “Nonlinear magic: multiphoton microscopy in the biosciences,” Nat. Biotechnol. 21(11), 1369–1377 (2003).
[Crossref] [PubMed]

Nat. Methods (1)

E. Papagiakoumou, F. Anselmi, A. Bègue, V. de Sars, J. Glückstad, E. Y. Isacoff, and V. Emiliani, “Scanless two-photon excitation of channelrhodopsin-2,” Nat. Methods 7(10), 848–854 (2010).
[Crossref] [PubMed]

Neuron (1)

P. S. Tsai, B. Friedman, A. I. Ifarraguerri, B. D. Thompson, V. Lev-Ram, C. B. Schaffer, Q. Xiong, R. Y. Tsien, J. A. Squier, and D. Kleinfeld, “All-optical histology using ultrashort laser pulses,” Neuron 39(1), 27–41 (2003).
[Crossref] [PubMed]

Opt. Commun. (2)

M. E. Durst, G. Zhu, and C. Xu, “Simultaneous spatial and temporal focusing in nonlinear microscopy,” Opt. Commun. 281(7), 1796–1805 (2008).
[Crossref] [PubMed]

P. Pronko, S. Dutta, J. Squier, V. Rudd, D. Du, and G. Mourou, “Machining of submicron holes using a femtosecond laser at 800 nm,” Opt. Commun. 114(1-2), 106–110 (1995).
[Crossref]

Opt. Express (11)

W. S. Kuo, C.-H. Lien, K.-C. Cho, C. Y. Chang, C.-Y. Lin, L. L. Huang, P. J. Campagnola, C. Y. Dong, and S. J. Chen, “Multiphoton fabrication of freeform polymer microstructures with gold nanorods,” Opt. Express 18(26), 27550–27559 (2010).
[Crossref] [PubMed]

K.-C. Cho, C.-H. Lien, C.-Y. Lin, C.-Y. Chang, L. L. H. Huang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “Enhanced two-photon excited fluorescence in three-dimensionally crosslinked bovine serum albumin microstructures,” Opt. Express 19(12), 11732–11739 (2011).
[Crossref] [PubMed]

C.-Y. Lin, C.-H. Lien, K.-C. Cho, C.-Y. Chang, N.-S. Chang, P. J. Campagnola, C. Y. Dong, and S.-J. Chen, “Investigation of two-photon excited fluorescence increment via crosslinked bovine serum albumin,” Opt. Express 20(13), 13669–13676 (2012).
[Crossref] [PubMed]

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Opt. Lett. (4)

Proc. Natl. Acad. Sci. U.S.A. (1)

A. Vaziri, J. Tang, H. Shroff, and C. V. Shank, “Multilayer three-dimensional super resolution imaging of thick biological samples,” Proc. Natl. Acad. Sci. U.S.A. 105(51), 20221–20226 (2008).
[Crossref] [PubMed]

Other (1)

M. H. Niemz, Laser-Tissue Interactions (Springer, 2007).

Supplementary Material (3)

» Media 1: AVI (1385 KB)     
» Media 2: AVI (1580 KB)     
» Media 3: AVI (1068 KB)     

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Figures (4)

Fig. 1
Fig. 1 Optical setup of the temporal focusing-based high-throughput multiphoton-induced ablation micromachining system.
Fig. 2
Fig. 2 (a) SHG images of chicken tendon after multiphoton-induced ablation machining at the depths of 0, 15, 45, and 75 μm (left to right), and (b) the cross-section of the 3D rendered SHG image corresponding to Fig. 2(a). (c) SHG images as in Fig. 2(a) but with the sample overturned. (d) The cross-section of the 3D rendered SHG image corresponding to Fig. 2(c). (e) SHG images at the same condition as Fig. 2(a) but with injected index matching oil, and (f) the cross-section of the 3D rendered SHG image corresponding to Fig. 2(e).
Fig. 3
Fig. 3 (a) SHG images of chicken tendon after multiphoton-induced ablation machining at the depths of 10, 20, 40, 60, and 70 μm (left to right) with a line-to-line interval of 30.0 μm, and (b) the cross-section of the 3D rendered SHG image corresponding to Fig. 3(a) (Media 1). (c) SHG images under the same conditions as Fig. 3(a) but with the smaller line-to-line interval of 20.0 μm, and (d) the cross-section of the 3D rendered SHG image corresponding to Fig. 3(c) (Media 2).
Fig. 4
Fig. 4 SHG images of chicken tendon via temporal focusing-based widefield multiphoton microscopy. (a) Depths are 10, 15, 20 and 25 μm from left to right, (b) projection image from the 3D reconstructed image of (a) (Media 3).

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