Abstract

Laminar flow in arteries causes streaming and uneven distribution of infused agents within the organ. This may lead to misinterpretation of experimental results and affect treatment outcomes. We monitor dynamical changes of superficial cortical blood flow in the rat kidney following different routes of administration of the vasoconstrictor angiotensin II. Our analysis reveals the appearance of large scale oscillations of the blood flow caused by inhomogeneous intra organ drug distribution.

© 2015 Optical Society of America

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  1. J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
    [Crossref] [PubMed]
  2. R. L. Dedrick, “Arterial drug infusion: pharmacokinetic problems and pitfalls,” J. Natl. Cancer Inst. 80, 84–89 (1988).
    [Crossref] [PubMed]
  3. N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
    [Crossref] [PubMed]
  4. R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
    [PubMed]
  5. N. Parekh, “A novel method for infusing drugs continuously into the renal artery of rats,” Am. J. Physiol. 268(5), F967–F971 (1995).
    [PubMed]
  6. S. M. Hamza and S. Kaufman, “A vibrator prevents streaming during close-arterial infusion into the kidney,” Am. J. Physiol. 286(4), F643–F646 (2004).
  7. W. A. Cupples and H. Sonnenberg, “Renal medullary plasma flow rate and reabsorption of salt and water from inner medullary collecting duct,” Can. J. Physiol. Pharmacol. 65, 2415–2421 (1987).
    [Crossref] [PubMed]
  8. N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).
  9. N.-H. Holstein-Rathlou and D. J. Marsh, “Renal blood flow regulation: a case study in nonlinear dynamics,” Physiol. Rev. 74, 637–681 (1994).
    [PubMed]
  10. P. P. Leyssac and L. Baumbach, “An oscillating intratubular pressure response to alterations in Henle loop flow in the rat kidney,” Acta Physiol. Scand. 117, 415–419 (1983).
    [Crossref] [PubMed]
  11. A. R. Brazhe, D. J. Marsh, N.-H. Holstein-Rathlou, and O. Sosnovtseva, “Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data,” PLoSOne 9, e105879 (2014).
    [Crossref]
  12. C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).
  13. H. Cheng, Y. Yan, and T. Q. Duong, “Temporal statistical analysis of laser speckle images and its application to retinal blood-flow imaging,” Opt. Express 16(14), 10214–10219 (2008).
    [Crossref] [PubMed]

2014 (1)

A. R. Brazhe, D. J. Marsh, N.-H. Holstein-Rathlou, and O. Sosnovtseva, “Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data,” PLoSOne 9, e105879 (2014).
[Crossref]

2013 (1)

C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).

2011 (1)

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

2008 (1)

2004 (1)

S. M. Hamza and S. Kaufman, “A vibrator prevents streaming during close-arterial infusion into the kidney,” Am. J. Physiol. 286(4), F643–F646 (2004).

2003 (1)

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

2000 (1)

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

1995 (1)

N. Parekh, “A novel method for infusing drugs continuously into the renal artery of rats,” Am. J. Physiol. 268(5), F967–F971 (1995).
[PubMed]

1994 (1)

N.-H. Holstein-Rathlou and D. J. Marsh, “Renal blood flow regulation: a case study in nonlinear dynamics,” Physiol. Rev. 74, 637–681 (1994).
[PubMed]

1988 (1)

R. L. Dedrick, “Arterial drug infusion: pharmacokinetic problems and pitfalls,” J. Natl. Cancer Inst. 80, 84–89 (1988).
[Crossref] [PubMed]

1987 (1)

W. A. Cupples and H. Sonnenberg, “Renal medullary plasma flow rate and reabsorption of salt and water from inner medullary collecting duct,” Can. J. Physiol. Pharmacol. 65, 2415–2421 (1987).
[Crossref] [PubMed]

1986 (1)

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

1983 (1)

P. P. Leyssac and L. Baumbach, “An oscillating intratubular pressure response to alterations in Henle loop flow in the rat kidney,” Acta Physiol. Scand. 117, 415–419 (1983).
[Crossref] [PubMed]

Arcieri, S.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Baumbach, L.

P. P. Leyssac and L. Baumbach, “An oscillating intratubular pressure response to alterations in Henle loop flow in the rat kidney,” Acta Physiol. Scand. 117, 415–419 (1983).
[Crossref] [PubMed]

Blacklock, J. B.

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Blasberg, R. G.

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Braam, B.

C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).

Brazhe, A. R.

A. R. Brazhe, D. J. Marsh, N.-H. Holstein-Rathlou, and O. Sosnovtseva, “Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data,” PLoSOne 9, e105879 (2014).
[Crossref]

Bubalo, J. S.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Caterino, M.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Cheng, H.

Chon, K. H.

C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).

Cortesi, E.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Cosimelli, M.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Cupples, W. A.

C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

W. A. Cupples and H. Sonnenberg, “Renal medullary plasma flow rate and reabsorption of salt and water from inner medullary collecting duct,” Can. J. Physiol. Pharmacol. 65, 2415–2421 (1987).
[Crossref] [PubMed]

Dedrick, R. L.

R. L. Dedrick, “Arterial drug infusion: pharmacokinetic problems and pitfalls,” J. Natl. Cancer Inst. 80, 84–89 (1988).
[Crossref] [PubMed]

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Doolittle, N. D.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Doppman, J. L.

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Duong, T. Q.

Filippini, A.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Fortin, D.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Garufi, C.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Hall, W. A.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Hamza, S. M.

S. M. Hamza and S. Kaufman, “A vibrator prevents streaming during close-arterial infusion into the kidney,” Am. J. Physiol. 286(4), F643–F646 (2004).

Holstein-Rathlou, N.-H.

A. R. Brazhe, D. J. Marsh, N.-H. Holstein-Rathlou, and O. Sosnovtseva, “Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data,” PLoSOne 9, e105879 (2014).
[Crossref]

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

N.-H. Holstein-Rathlou and D. J. Marsh, “Renal blood flow regulation: a case study in nonlinear dynamics,” Physiol. Rev. 74, 637–681 (1994).
[PubMed]

Jerome, E.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Kaufman, S.

S. M. Hamza and S. Kaufman, “A vibrator prevents streaming during close-arterial infusion into the kidney,” Am. J. Physiol. 286(4), F643–F646 (2004).

Kraemer, D. F.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Leyssac, P. P.

P. P. Leyssac and L. Baumbach, “An oscillating intratubular pressure response to alterations in Henle loop flow in the rat kidney,” Acta Physiol. Scand. 117, 415–419 (1983).
[Crossref] [PubMed]

Lutz, R. J.

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Mancini, R.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Marsh, D. J.

A. R. Brazhe, D. J. Marsh, N.-H. Holstein-Rathlou, and O. Sosnovtseva, “Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data,” PLoSOne 9, e105879 (2014).
[Crossref]

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

N.-H. Holstein-Rathlou and D. J. Marsh, “Renal blood flow regulation: a case study in nonlinear dynamics,” Physiol. Rev. 74, 637–681 (1994).
[PubMed]

McAllister, L. D.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Miner, M. E.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Mitrou, N.

C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).

Muldoon, L. L.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Neuwelt, E. A.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Nixon, R.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Oldfield, E. H.

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Osztie, E.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Parekh, N.

N. Parekh, “A novel method for infusing drugs continuously into the renal artery of rats,” Am. J. Physiol. 268(5), F967–F971 (1995).
[PubMed]

Pavlov, A. N.

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

Pizzi, G.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Scully, C. G.

C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).

Siegal, T.

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

Sonnenberg, H.

W. A. Cupples and H. Sonnenberg, “Renal medullary plasma flow rate and reabsorption of salt and water from inner medullary collecting duct,” Can. J. Physiol. Pharmacol. 65, 2415–2421 (1987).
[Crossref] [PubMed]

Sorensen, C. M.

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

Sosnovtseva, O.

A. R. Brazhe, D. J. Marsh, N.-H. Holstein-Rathlou, and O. Sosnovtseva, “Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data,” PLoSOne 9, e105879 (2014).
[Crossref]

Sosnovtseva, O. V.

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

Sperduti, I.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Spila, A.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Tedesco, M.

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Wright, D. C.

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Yan, Y.

Acta Physiol. Scand. (1)

P. P. Leyssac and L. Baumbach, “An oscillating intratubular pressure response to alterations in Henle loop flow in the rat kidney,” Acta Physiol. Scand. 117, 415–419 (1983).
[Crossref] [PubMed]

Am. J. Physiol. (4)

C. G. Scully, N. Mitrou, B. Braam, W. A. Cupples, and K. H. Chon, “Detecting physiological systems with laser speckle perfusion imaging of the renal cortex,” Am. J. Physiol. 304, R929–R939 (2013).

N. Parekh, “A novel method for infusing drugs continuously into the renal artery of rats,” Am. J. Physiol. 268(5), F967–F971 (1995).
[PubMed]

S. M. Hamza and S. Kaufman, “A vibrator prevents streaming during close-arterial infusion into the kidney,” Am. J. Physiol. 286(4), F643–F646 (2004).

N.-H. Holstein-Rathlou, O. V. Sosnovtseva, A. N. Pavlov, W. A. Cupples, C. M. Sorensen, and D. J. Marsh, “Nephron blood flow dynamics measured by laser speckle contrast imaging,” Am. J. Physiol. 300, F319–F329 (2011).

Anticancer Res. (1)

R. Mancini, M. Tedesco, C. Garufi, A. Filippini, S. Arcieri, M. Caterino, G. Pizzi, E. Cortesi, A. Spila, I. Sperduti, and M. Cosimelli, “Hepatic arterial infusion (HAI) of cisplatin and systemic fluorouracil in the treatment of unresectable colorectal liver metastases,” Anticancer Res. 23, 1837–1841 (2003).
[PubMed]

Can. J. Physiol. Pharmacol. (1)

W. A. Cupples and H. Sonnenberg, “Renal medullary plasma flow rate and reabsorption of salt and water from inner medullary collecting duct,” Can. J. Physiol. Pharmacol. 65, 2415–2421 (1987).
[Crossref] [PubMed]

Cancer (1)

N. D. Doolittle, M. E. Miner, W. A. Hall, T. Siegal, E. Jerome, E. Osztie, L. D. McAllister, J. S. Bubalo, D. F. Kraemer, D. Fortin, R. Nixon, L. L. Muldoon, and E. A. Neuwelt, “Safety and efficacy of a multicenter study using intraarterial chemotherapy in conjunction with osmotic opening of the blood-brain barrier for the treatment of patients with malignant brain tumors,” Cancer 88, 637–647 (2000).
[Crossref] [PubMed]

J. Natl. Cancer Inst. (1)

R. L. Dedrick, “Arterial drug infusion: pharmacokinetic problems and pitfalls,” J. Natl. Cancer Inst. 80, 84–89 (1988).
[Crossref] [PubMed]

J. Neurosurg. (1)

J. B. Blacklock, D. C. Wright, R. L. Dedrick, R. G. Blasberg, R. J. Lutz, J. L. Doppman, and E. H. Oldfield, “Drug streaming during intra-arterial chemotherapy,” J. Neurosurg. 64, 284–291 (1986).
[Crossref] [PubMed]

Opt. Express (1)

Physiol. Rev. (1)

N.-H. Holstein-Rathlou and D. J. Marsh, “Renal blood flow regulation: a case study in nonlinear dynamics,” Physiol. Rev. 74, 637–681 (1994).
[PubMed]

PLoSOne (1)

A. R. Brazhe, D. J. Marsh, N.-H. Holstein-Rathlou, and O. Sosnovtseva, “Synchronized renal blood flow dynamics mapped with wavelet analysis of laser speckle flowmetry data,” PLoSOne 9, e105879 (2014).
[Crossref]

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Figures (4)

Fig. 1
Fig. 1

Difference mapping of the AngII effect. L(x,y) values are color-coded (see colorbar). Top panel: Systemic infusion of AngII uniformly affects superficial renal cortical blood flow. Horizontal bar corresponds to 2.5 mm. Middle panel: Continuous intrarenal infusion directly into the renal artery. Different patterns of inhomogeneity are observed. Bottom panel: Bolus injections directly into the renal artery at two different doses. There is strong inhomogeneity with increasing area of the effect as concentration of AngII increases.

Fig. 2
Fig. 2

Relative area of the regions affected by AngII for all groups of rats. One can see that most of the intrarenal infusions result in smaller areas being affected, and therefore in greater spatial inhomogeneity.

Fig. 3
Fig. 3

Dynamical features of heterogeneity for intrarental infusions of AngII. Top panel: Snapshots of blood flow images at different moments of time, BFI index is color-coded according to the scale on the right side of the panel. Bottom panel, left: The average time series recorded from the regions R1 and R2. Bottom panel, right: Fourier relation map for the frequency band [0.0015; 0.015] Hz. Color-coded map shows F(x,y) values. There are two regions with well-pronounced very slow oscillations corresponding to alternating patterns in the top panel.

Fig. 4
Fig. 4

Comparison of blood flow dynamics recorded by full-field LSF technique (left) and integral blood flow by ultrasonic probe on the renal artery (right). Top panel: Time series from blood flow images recorded from the region of the kidney surface affected (red) and not affected (blue) by AngII show high variability compared to the recordings of total renal blood flow (right panel). Bottom panel: Fourier spectra averaged over the kidney surface after (magenta) the infusion of AngII contain new low frequency components in comparison with Fourier spectra obtained before (green) infusion AngII, as well as from the renal blood flow recordings. One can see that total renal blood flow do not reflect the complex dynamics of local blood flow in the kidney.

Tables (1)

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Table 1 Relative area (%) affected by AngII. Calculations are performed on the basis of amplification of the very slow frequency range in Fourier spectra.

Equations (3)

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B F I = I ¯ 2 / σ 2 .
L ( x , y ) = ( L ¯ control ( x , y ) L ¯ AngII ( x , y ) ) / L ¯ control ( x , y ) .
F ( x , y ) = F ¯ AngII ( x , y ) / F ¯ control ( x , y ) ,

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